IL-27 (human):Fc (human) (rec.) (non-lytic)

IL-27 (human):Fc (human) (rec.) (non-lytic)
Item number Size Datasheet Manual SDS Delivery time Quantity Price
CHI-HF-22027-C050 50 µg - -

3 - 9 business days*

468.00€
 
The human IL-27 complex composed of the Ebi3 subunit (aa 21-229) and the p28 subunit (aa 26-243)... more
Product information "IL-27 (human):Fc (human) (rec.) (non-lytic)"
The human IL-27 complex composed of the Ebi3 subunit (aa 21-229) and the p28 subunit (aa 26-243) is fused through a polypeptide linker to the Fc portion of a mutant human IgG1. Lyophilized from 0.2µm-filtered solution in PBS. Shows the biological function of the IL-27 moiety and exerts a prolonged circulating half-life caused by the modified Fc domain. Interleukin-27 (IL-27) is a heterodimeric group 2 receptor ligand molecule that belongs to the IL-6/IL-12 family of long type I cytokines. It is composed of EBI3 (EBV-induced gene 3), a 34 kDa glycoprotein that is related to the p40 subunit of IL-12 and IL-23, and p28, the cloned 28 kDa glycoprotein that is related to the p35 chain of IL-12. IL-27 is expressed by monocytes, endothelial cells and dendritic cells. IL-27 binds to and signals through a heterodimeric receptor complex composed of WSX1 (TCCR) and gp130. Evidence suggests IL-27 interacts only with WSX-1. IL-27 has both anti- and proinflammatory properties. As an antiinflammatory, IL-27 seems to induce a general negative feedback program that limits T and NK-T cell activity. At the onset of infection, IL-27 induces an IL-12 receptor on naïe CD4 T cells, making them susceptible to subsequent IL-12 activity (and possible Th1 development). Notably, IL-12 family cytokines are both induced and inhibited by bacterial products. Microbes promote IL-27 secretion through TLR4, and also block IL-27 production via C5a induction.
Keywords: Interleukin-27, EBI3, IL27B, IL-27B, IL-27 subunit beta, EBV-induced gene 3 protein, Interleukin-27 subunit beta, Epstein-Barr virus-induced gene 3 protein, p28, IL27, IL27A, IL27-A, IL-27-A, IL-27 subunit alpha, Interleukin-27 subunit alpha
Supplier: Chimerigen Laboratories
Supplier-Nr: HF-22027

Properties

Application: Bioassays
Conjugate: No
Host: Hamster cells
Species reactivity: human
Purity: >98%
Format: Lyophilized

Database Information

UniProt ID : Q14213 | Matching products
Gene ID GeneID 10148 | Matching products

Handling & Safety

Storage: -20°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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