Anti-EXOSC4

Anti-EXOSC4
Item number Size Datasheet Manual SDS Delivery time Quantity Price
A303-775A-T 10 µl (10 µg) -

2 - 8 business days*

164.00€
A303-775A 100 µl (100 µg) -

2 - 8 business days*

588.00€
 
Protein function: Non-catalytic component of the RNA exosome complex which has 3'->5'... more
Product information "Anti-EXOSC4"
Protein function: Non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA. The catalytic inactive RNA exosome core complex of 9 subunits (Exo-9) is proposed to play a pivotal role in the binding and presentation of RNA for ribonucleolysis, and to serve as a scaffold for the association with catalytic subunits and accessory proteins or complexes. EXOSC4 binds to ARE-containing RNAs. [The UniProt Consortium]
Keywords: Anti-p12A, Anti-RRP41, Anti-EXOSC4, Anti-Exosome component 4, Anti-Exosome complex component RRP41, Anti-Ribosomal RNA-processing protein 41
Supplier: Bethyl Laboratories
Supplier-Nr: A303-775A

Properties

Application: WB, IP
Antibody Type: Polyclonal
Conjugate: No
Host: Rabbit
Species reactivity: human (Expected: mouse, bovine)
Immunogen: Synthetic peptide. The epitope recognized by A303-775A maps to a region between residue 50 and 100 of human EXOSC4, exosome component 4 using the numbering given in entry NP_061910.1 (GeneID 54512).
Format: Antigen Affinity Purified

Handling & Safety

Storage: +4°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
You will get a certificate here
or to request a certificate of analysis.
Read, write and discuss reviews... more
Customer review for "Anti-EXOSC4"
Write a review
or to review a product.
Viewed