4 products were found matching "Cay10010374-%25"!

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GW 842166X
GW 842166X

Item number: Cay10010372-25

GW 842166X is a cannabinoid 2 (CB2) receptor agonist. It increases intracellular calcium mobilization induced by the CB receptor agonist CP 55,940 (Cay-13241) in HEK cells co-expressing a chimeric Galphaq/05 protein and the human CB2 receptor (EC50 = 7.78 µM). GW 842166X is selective for CB2 over the CB1 receptor...
Keywords: 2-[(2,4-dichlorophenyl)amino]-N-[(tetrahydro-2H-pyran-4-yl)methyl]-4-(trifluoromethyl)-5-pyrimidinecarboxamide
Application: CB2 receptor agonist
CAS 666260-75-9
MW: 449.3 D
From 30.00€ *
Review
Simvastatin
Simvastatin

Item number: Cay10010344-25

Simvastatin is a competitive inhibitor of HMG-CoA reductase (Ki = 0.12 nM). Simvastatin reduces plasma cholesterol levels in rats and dogs when administered at doses of 1.2 and 8 mg/kg, respectively. Simvastatin suppresses TNF-induced NF-kappaB activation (IC50 = ~13 µM) and potentiates apoptosis in human myeloid...
Keywords: MK-733,...
Application: HMG-CoA reductase inhibitor
CAS 79902-63-9
MW: 418.6 D
From 43.00€ *
Review
Fluvastatin
Fluvastatin

Item number: Cay10010334-25

Fluvastatin is an inhibitor of HMG-CoA reductase (Ki = 0.3 nM for the rat enzyme). It also inhibits the human cytochrome P450 (CYP) isoform CYP2C9 (IC50 = 100 nM). Fluvastatin inhibits oxidized LDL-induced ferroptosis and reverses oxidized LDL-induced decreases in glutathione peroxidase 4 (GPX4) and system Xc-...
Keywords: 7-[3-(4-fluorophenyl)-1-(1-methylethyl)-1H-indol-2-yl]-3,5-dihydroxy-6-heptenoic acid
Application: HMG-CoA reductase inhibitor
CAS 93957-54-1
MW: 411.5 D
From 54.00€ *
Review
AG-213
AG-213

Item number: Cay10010314-25

Protein tyrosine kinase (PTK) inhibitors are potential antiproliferative agents for diseases caused by the hyperactivity of PTKs. Tyrphostins are a class of antiproliferative compounds that act as PTK blockers. PTK inhibitors which preferentially inhibit the epidermal growth factor (EGF) receptor kinase block...
Keywords: Tyrphostin 47, Tyrphostin AG-213, 2-cyano-3-(3,4-dihydroxyphenyl)-2E-propenethioamide
Application: EGF receptor kinase inhibitor
CAS 122520-86-9
MW: 220.2 D
From 77.00€ *
Review