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81.957 Treffer print
ART-NR PRODUKT HERSTELLER MENGE PREIS
A0903-10.200
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WB, IHC, FC Erklärungen der Abkürzungen ansehen.
Catalyzes an early step in the biosynthesis of tetrapyrroles. Binds two molecules of 5-aminolevulinate per subunit, each at a distinct site, and catalyzes their condensation to form porphobilinogen. [The UniProt Consortium]

Rabbit IgG SR: human
Immunogen: Synthetic peptide selected from the C-terminal region of human ALAD (KLH).
USBio
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200 µl

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521 €


A2298-74W.100
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Rabbit SR: human, mouse, rat
Immunogen: Synthetic peptide corresponding to the N-terminal of human ATG3 protein conjugated to Blue Carrier Protein.
USBio
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100 µl

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544 €


C2442-32L.100
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Rabbit IgG SR: human, mouse, rat
Immunogen: Synthetic peptide corresponding to residues surrounding aa32 of mouse Fas.
USBio
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100 µg

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456 €


C5069-52.100 Chorionic Gonadotropin, Human, alpha (hCGa), Purified USBio
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100 µg

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399 €


C7510-11.10 Collagen Type I, Bovine (FITC)
Collagenase substrate Erklärungen der Abkürzungen ansehen.
USBio
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10 mg

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451 €


C8475-15.1 gamma-​Cyclodextrin (Cycloheptaamylose)
CAS: 17465-​86-​0
Molecular Formula: C48H80O40 . Mw: 1297,15.

MW: 1.297 D
Formula: C48H80O40
USBio
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1 g

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140 €


C9100-18.100
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Mouse IgG2a SR: human
USBio
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100 µg

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436 €


E3550-03A.1
ELISA Erklärungen der Abkürzungen ansehen.
Purity: Purified by Protein A chr
Mouse IgG2a kappa SR: human
Immunogen: Estradiol-6-CMO-BSA.
USBio
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1 mg

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504 €


H1840-10.100
ELISA, WB, IHC Erklärungen der Abkürzungen ansehen.
Rabbit
USBio
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100 µg

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168 €


M2200.1 Manganese Sulfate Monohydrate (Manganous Sulfate Monohydrate)
CAS: 10034-​96-​5
Molecular Formula: MnSO4.H2O. Mw: 169,02.

MW: 169 D
Formula: MnSO4.H2O
USBio
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1 kg

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56 €


M4615.500 MOPS Sodium Salt (Morpholinopropanesulfonic acid sodium salt)
CAS: 71119-​22-​7
Molecular Formula: C7H14NO4SNa. Mw: 231,2.

MW: 231 D
Formula: C7H14NO4S.Na
USBio
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500 g

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205 €


N2169-30.100
IHC, ICC, IF Erklärungen der Abkürzungen ansehen.
Rabbit SR: human, mouse, rat
USBio
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100 µg

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601 €


P9113-22.500 Proteose Peptone 3 (Powder) (BSE-​Free) USBio
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500 g

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185 €


P9563.100
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Rabbit SR: rabbit
USBio
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100 µg

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588 €


P4072.100 Phosphodiesterase I (EC 3.1.4.1, Crotalus adamanteus venom) USBio
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100 U

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268 €


029968.100
ELISA, WB Erklärungen der Abkürzungen ansehen.
Protein function: Steroid hormone receptors are ligand-activated transcription factors that regulate eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Transcription factor activity is modulated by bound coactivator and corepressor proteins. Transcription activation is down-regulated by NR0B2. Activated, but not phosphorylated, by HIPK3 and ZIPK/DAPK3. [The UniProt Consortium]

Mouse IgG1 SR: human
Immunogen: Purified recombinant fragment of AR (aa689-919) expressed in E. coli.
USBio
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100 µl

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454 €

A2281-01A.250
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WB, IP, IHC, IF Erklärungen der Abkürzungen ansehen.
Steroid hormone receptors are ligand-activated transcription factors that regulate eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Transcription factor activity is modulated by bound coactivator and corepressor proteins. Transcription activation is down-regulated by NR0B2. Activated, but not phosphorylated, by HIPK3 and ZIPK/DAPK3. [The UniProt Consortium]

Rabbit IgG SR: human, mouse, rat
Immunogen: synthetic peptide derived from N-terminal of rat AR.
USBio
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250 µl

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334 €

A2281-01B-P.100
ELISA Erklärungen der Abkürzungen ansehen.
Steroid hormone receptors are ligand-activated transcription factors that regulate eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Transcription factor activity is modulated by bound coactivator and corepressor proteins. Transcription activation is down-regulated by NR0B2. Activated, but not phosphorylated, by HIPK3 and ZIPK/DAPK3. [The UniProt Consortium]
USBio
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100 µg

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347 €

A2281-01B.100
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ELISA, WB Erklärungen der Abkürzungen ansehen.
Steroid hormone receptors are ligand-activated transcription factors that regulate eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Transcription factor activity is modulated by bound coactivator and corepressor proteins. Transcription activation is down-regulated by NR0B2. Activated, but not phosphorylated, by HIPK3 and ZIPK/DAPK3. [The UniProt Consortium]

Goat SR: human, monkey, mouse, rat
Immunogen: EVQLGLGRVYPRPPSC, N Terminus
USBio
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100 µg

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464 €

A2281-01D.100
ELISA, FC Erklärungen der Abkürzungen ansehen.
Steroid hormone receptors are ligand-activated transcription factors that regulate eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Transcription factor activity is modulated by bound coactivator and corepressor proteins. Transcription activation is down-regulated by NR0B2. Activated, but not phosphorylated, by HIPK3 and ZIPK/DAPK3. [The UniProt Consortium]

Mouse IgG2B SR: human
Immunogen: E. coli-derived, recombinant human Androgen R (aa661-920, Accession # P10275).
USBio
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100 µg

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535 €

A2281-01S.100
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ELISA, WB Erklärungen der Abkürzungen ansehen.
Steroid hormone receptors are ligand-activated transcription factors that regulate eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Transcription factor activity is modulated by bound coactivator and corepressor proteins. Transcription activation is down-regulated by NR0B2. Activated, but not phosphorylated, by HIPK3 and ZIPK/DAPK3. [The UniProt Consortium]

Sheep IgG SR: human
Immunogen: Purified, E. coli-derived, recombinant human Androgen Receptor (aa660-919, Accession # P10275).
USBio
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100 µg

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712 €

A2281-02A.200
WB, IHC Erklärungen der Abkürzungen ansehen.
Steroid hormone receptors are ligand-activated transcription factors that regulate eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Transcription factor activity is modulated by bound coactivator and corepressor proteins. Transcription activation is down-regulated by NR0B2. Activated, but not phosphorylated, by HIPK3 and ZIPK/DAPK3. [The UniProt Consortium]

Rabbit IgG SR: human, mouse
Immunogen: Synthetic peptide HPHARIKLENPLDD containing a predicted sumoylation site from the central region of human ANDR (KLH).
USBio
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200 µl

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521 €

A2281-04A.100
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WB, IHC, FC, IF Erklärungen der Abkürzungen ansehen.
Steroid hormone receptors are ligand-activated transcription factors that regulate eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Transcription factor activity is modulated by bound coactivator and corepressor proteins. Transcription activation is down-regulated by NR0B2. Activated, but not phosphorylated, by HIPK3 and ZIPK/DAPK3. [The UniProt Consortium]

Rabbit SR: human
USBio
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100 µl

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510 €

A2281-05A.100
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WB, FC Erklärungen der Abkürzungen ansehen.
Steroid hormone receptors are ligand-activated transcription factors that regulate eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Transcription factor activity is modulated by bound coactivator and corepressor proteins. Transcription activation is down-regulated by NR0B2. Activated, but not phosphorylated, by HIPK3 and ZIPK/DAPK3. [The UniProt Consortium]

Purity: Supernatant
Rabbit IgG SR: human, mouse, rat
Immunogen: A synthetic peptide corresponding to residues on the C-terminus of human Androgen Receptor.
USBio
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100 µl

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537 €

A2281-06G.100
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ELISA, WB, IHC Erklärungen der Abkürzungen ansehen.
Steroid hormone receptors are ligand-activated transcription factors that regulate eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Transcription factor activity is modulated by bound coactivator and corepressor proteins. Transcription activation is down-regulated by NR0B2. Activated, but not phosphorylated, by HIPK3 and ZIPK/DAPK3. [The UniProt Consortium]

Mouse IgG1 SR: human, mouse
Immunogen: Purified recombinant fragment of human Androgen Receptor (AR) expressed in E.coli.
USBio
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100 µl

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454 €

A2281-13C.100
IHC Erklärungen der Abkürzungen ansehen.
Steroid hormone receptors are ligand-activated transcription factors that regulate eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Transcription factor activity is modulated by bound coactivator and corepressor proteins. Transcription activation is down-regulated by NR0B2. Activated, but not phosphorylated, by HIPK3 and ZIPK/DAPK3. [The UniProt Consortium]

Mouse IgG2A SR: human
Immunogen: Recombinant corresponding to aa660-919 from human Androgen R/NR3C4 expressed in E. coli (P10275).
USBio
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100 µg

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535 €

A2281-13D.100
neu

FC Erklärungen der Abkürzungen ansehen.
Steroid hormone receptors are ligand-activated transcription factors that regulate eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Transcription factor activity is modulated by bound coactivator and corepressor proteins. Transcription activation is down-regulated by NR0B2. Activated, but not phosphorylated, by HIPK3 and ZIPK/DAPK3. [The UniProt Consortium]

Mouse IgG2b SR: human
Immunogen: Recombinant corresponding to aa661-920 from human Androgen R expressed in E. coli (P10275).
USBio
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100 tests

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696 €

A2281-13E.100
neu

FC Erklärungen der Abkürzungen ansehen.
Steroid hormone receptors are ligand-activated transcription factors that regulate eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Transcription factor activity is modulated by bound coactivator and corepressor proteins. Transcription activation is down-regulated by NR0B2. Activated, but not phosphorylated, by HIPK3 and ZIPK/DAPK3. [The UniProt Consortium]

Mouse IgG2b SR: human, mouse, rat
Immunogen: Recombinant corresponding to aa661-920 from human Androgen R expressed in E. coli (P10275).
USBio
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100 tests

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628 €

030519.100
ELISA, WB, IHC Erklärungen der Abkürzungen ansehen.
Protein function: Acts as a tumor suppressor in many tumor types, induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. In cooperation with mitochondrial PPIF is involved in activating oxidative stress-induced necrosis, the function is largely independent of transcription. Induces the transcription of long intergenic non-coding RNA p21 (lincRNA-p21) and lincRNA- Mkln1. LincRNA-p21 participates in TP53-dependent transcriptional repression leading to apoptosis and seem to have to effect on cell-cycle regulation. Implicated in Notch signaling cross-over. Prevents CDK7 kinase activity when associated to CAK complex in response to DNA damage, thus stopping cell cycle progression. Isoform 2 enhances the transactivation activity of isoform 1 from some but not all TP53-inducible promoters. Isoform 4 suppresses transactivation activity and impairs growth suppression mediated by isoform 1. Isoform 7 inhibits isoform 1-mediated apoptosis. [The UniProt Consortium]

Mouse IgG1 SR: human
Immunogen: Recombinant protein corresponding to a fragment of human p53, expressed in E. coli (Gene ID 7157).
USBio
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100 µl

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454 €

134615.50
neu

WB, IF Erklärungen der Abkürzungen ansehen.
Purity: Purified by Protein A aff
Mouse IgG SR: human
Immunogen: Full length human TP53, aa1-393 (NP_000537).
USBio
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50 µg

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517 €

134616.100
neu

WB, IP Erklärungen der Abkürzungen ansehen.
Purity: Serum
Rabbit IgG SR: human
Immunogen: Full length human TP53, aa1-393 (NP_000537.2).
USBio
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100 µl

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543 €

134617.100
neu

WB Erklärungen der Abkürzungen ansehen.
Purity: Purified by Protein A aff
Rabbit IgG SR: human
Immunogen: Full length human TP53, aa1-393 (NP_000537.2).
USBio
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100 µg

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543 €

134618.100
neu

ELISA, WB, IHC Erklärungen der Abkürzungen ansehen.
Purity: Purified by Protein A aff
Mouse IgG1 kappa SR: human
Immunogen: Partial recombinant corresponding to aa94-201 from human TP53 (AAH03596) with GST tag. MW of the GST tag alone is 26kD.
USBio
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100 µg

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517 €

136310.50
neu

ELISA, IHC, IF Erklärungen der Abkürzungen ansehen.
Rabbit IgG SR: human
Immunogen: Synthetic peptide corresponding to 379aa from human 53/p53.
USBio
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50 µg

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642 €

136486.50
neu

ELISA, WB, IHC, IF Erklärungen der Abkürzungen ansehen.
Rabbit IgG SR: human
Immunogen: Synthetic peptide corresponding to human TP53/p53 at C-Terminal.
USBio
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50 µg

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642 €

136487.50
neu

ELISA, WB, IHC Erklärungen der Abkürzungen ansehen.
Rabbit IgG SR: human, rat
Immunogen: Synthetic peptide corresponding to human TP53/p53 at N-Terminal.
USBio
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50 µg

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642 €

136488.50
neu

ELISA, WB, IHC, IF Erklärungen der Abkürzungen ansehen.
Rabbit IgG SR: human, mouse, rat
Immunogen: Synthetic peptide corresponding to human TP53/p53 at N-Terminal.
USBio
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50 µg

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642 €

138581.100
neu

WB, IP, IHC Erklärungen der Abkürzungen ansehen.
Mouse IgG2b kappa SR: human
Immunogen: Recombinant protein fragment corresponding to human p53.
USBio
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100 µl

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271 €

138581.500
neu

WB, IP, IHC Erklärungen der Abkürzungen ansehen.
Mouse IgG2b kappa SR: human
Immunogen: Recombinant protein fragment corresponding to human p53.
USBio
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500 µl

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411 €

P1001-26A.500
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WB, IP, FC Erklärungen der Abkürzungen ansehen.
Mouse IgG1 SR: human
USBio
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500 µl

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384 €

P1001-26A1.100
FC Erklärungen der Abkürzungen ansehen.
Mouse IgG2a SR: bovine, horse, cat, human
USBio
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100 µg

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566 €

P1001-26A4.100
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WB, IP, IHC Erklärungen der Abkürzungen ansehen.
Mouse IgG1 SR: human
USBio
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100 µg

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745 €

P1001-26A5.100
FC Erklärungen der Abkürzungen ansehen.
Mouse IgG2a SR: bovine, horse, cat, human
USBio
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100 tests

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595 €

P1001-26A6.100
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WB, Gel Erklärungen der Abkürzungen ansehen.
Rabbit SR: human, monkey
USBio
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100 µl

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576 €

P1001-26A8.100
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WB, IHC Erklärungen der Abkürzungen ansehen.
Mouse IgG2a SR: human
Immunogen: Human p53
USBio
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100 µg

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755 €

P1001-26AX.100
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WB, IP, FC Erklärungen der Abkürzungen ansehen.
Mouse IgG1 SR: human
USBio
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100 µl

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521 €

P1001-26B2.100
neu

WB Erklärungen der Abkürzungen ansehen.
Purity: Purified by immunoaffinit
Rabbit IgG SR: human
Immunogen: Synthesized non-phosphopeptide derived from human p53 around the phosphorylation site of serine 9 (D-P-SP-V-E).
USBio
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100 µg

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372 €

P1001-26D1.100
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WB, IP, IHC, ICC Erklärungen der Abkürzungen ansehen.
Mouse kappa kappa SR: human, mammalian, mouse, rat
USBio
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100 µg

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534 €

P1001-26D2.100
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Mouse IgG1 SR: human
USBio
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100 µg

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344 €

P1001-26E.500
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Mouse IgG2b SR: human
USBio
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500 µl

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501 €

P1001-26EX.100
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Mouse IgG2b SR: human
USBio
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100 µl

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540 €

P1001-26F.500
neu

IHC Erklärungen der Abkürzungen ansehen.
Rabbit IgG SR: human
Immunogen: Recombinant protein corresponding to full length human wild type p53 protein.
USBio
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500 µl

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551 €

P1001-26G.100
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WB, IP, IHC, FC Erklärungen der Abkürzungen ansehen.
Mouse IgG2b SR: human
USBio
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100 µg

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556 €

P1001-26H.100
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Mouse IgG1 SR: human
USBio
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100 µg

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566 €

P1001-26I.250
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WB, IP, IHC Erklärungen der Abkürzungen ansehen.
Sheep SR: human, mouse, rat
USBio
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250 µg

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498 €

P1001-26J.100
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WB, IP, IHC Erklärungen der Abkürzungen ansehen.
Mouse IgG1 SR: human
USBio
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100 µg

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566 €

P1001-26K.100
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ELISA, WB, IP, IHC, ICC Erklärungen der Abkürzungen ansehen.
Mouse IgG2a SR: human, monkey
Immunogen: Recombinant human wild-type p53 protein.
USBio
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100 µg

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575 €

P1001-26K1.100
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WB, IHC, FC Erklärungen der Abkürzungen ansehen.
Mouse IgG1 kappa SR: human
Immunogen: Recombinant human p53 protein.
USBio
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100 µg

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519 €

P1001-26L.100
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WB, IP, IHC Erklärungen der Abkürzungen ansehen.
Mouse IgG1 SR: human
USBio
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100 µg

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566 €

P1001-26M.100
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WB, IP, IHC Erklärungen der Abkürzungen ansehen.
Mouse IgG2a SR: human
USBio
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100 µg

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566 €

P1001-26N.100
WB, IHC, FC Erklärungen der Abkürzungen ansehen.
Mouse IgG1 kappa SR: human
Immunogen: Murine p53 fragment expressed in E. coli
USBio
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100 µg

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427 €

P1001-26N1.100
WB, IHC, FC Erklärungen der Abkürzungen ansehen.
Mouse IgG1 kappa SR: human
Immunogen: Murine p53 fragment expressed in E. coli
USBio
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100 µg

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442 €

P1001-26N2.120
WB, IHC, FC Erklärungen der Abkürzungen ansehen.
Mouse IgG1 kappa SR: human
Immunogen: Murine p53 expressed in E. coli
USBio
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120 tests

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481 €

P1001-26N3.120
WB, IHC, FC Erklärungen der Abkürzungen ansehen.
Mouse IgG1 kappa SR: human
Immunogen: Murine p53 expressed in E. coli
USBio
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120 tests

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543 €

P1001-26N4.1
WB, IHC Erklärungen der Abkürzungen ansehen.
Mouse IgG2b SR: human
Immunogen: Recombinant human wild type p53 protein.
USBio
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1 ml

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923 €

P1001-26N5.100
neu

ELISA, WB Erklärungen der Abkürzungen ansehen.
Purity: Purified by immunoaffinit
Mouse IgG2b SR: human
Immunogen: P53 N-terminal linear epitope aa20-25.
USBio
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100 µg

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415 €

P1001-26N5.25
neu

ELISA, WB Erklärungen der Abkürzungen ansehen.
Purity: Purified by immunoaffinit
Mouse IgG2b SR: human
Immunogen: P53 N-terminal linear epitope aa20-25.
USBio
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25 µg

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299 €

P1001-26R.100
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ELISA, WB, IP, IHC Erklärungen der Abkürzungen ansehen.
Mouse IgG2a SR: bovine, horse, cat, human
USBio
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100 µg

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466 €

P1001-26T.1
WB, IHC Erklärungen der Abkürzungen ansehen.
Mouse IgG2a SR: bovine, human
Immunogen: Human recombinant wild type p53 protein.
USBio
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1 ml

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900 €

P1001-26T1.100
neu

WB, IP Erklärungen der Abkürzungen ansehen.
Purity: Purified by immunoaffinit
Mouse IgG2a SR: human
Immunogen: P53 N-terminal linear epitope aa20-25.
USBio
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100 µg

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415 €

P1001-26T1.25
neu

WB, IP Erklärungen der Abkürzungen ansehen.
Purity: Purified by immunoaffinit
Mouse IgG2a SR: human
Immunogen: P53 N-terminal linear epitope aa20-25.
USBio
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25 µg

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299 €

P1001-26U.100
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WB, IP Erklärungen der Abkürzungen ansehen.
Mouse IgG1 SR: human
USBio
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100 µg

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566 €

P1001-26U1.100
FC Erklärungen der Abkürzungen ansehen.
Mouse IgG2a SR: human
Immunogen: Recombinant human p53
USBio
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100 µg

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556 €

P1001-26V.100
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Rabbit SR: human, rat
Immunogen: synthetic peptide
USBio
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100 µl

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537 €

P1001-26Y.1
IHC Erklärungen der Abkürzungen ansehen.
Rabbit SR: human
USBio
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1 ml

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1263 €

P1001-26Z.50
ELISA, WB, IP, IHC Erklärungen der Abkürzungen ansehen.
Mouse IgG2a kappa SR: human
Immunogen: Recombinant corresponding to human TP53.
USBio
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50 µg

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601 €

P1001-27.100
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ELISA, WB, IP Erklärungen der Abkürzungen ansehen.
MW: 53
Mouse IgG1 SR: human, monkey, mouse, rat
USBio
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100 µl

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479 €

P1001-27A.100
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MW: 53 kD
Rabbit SR: human, monkey, rat
USBio
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100 µl

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479 €

P1001-27B.100
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MW: 53 kD
Rabbit SR: human
USBio
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100 µl

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528 €

P1001-27B1.25
ELISA, WB Erklärungen der Abkürzungen ansehen.
Rabbit IgG SR: human
Immunogen: Synthetic phosphopeptide (LMLpSPDD) corresponding to human p53 at the phosphorylated site of Serine 46.
USBio
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25 µg

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411 €

P1001-27C.100
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ELISA, WB Erklärungen der Abkürzungen ansehen.
MW: 53 kD
Rabbit SR: human, mouse
USBio
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100 µl

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528 €

P1001-27C1.10
ELISA, WB, ICC Erklärungen der Abkürzungen ansehen.
Protein function: Acts as a tumor suppressor in many tumor types, induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. In cooperation with mitochondrial PPIF is involved in activating oxidative stress-induced necrosis, the function is largely independent of transcription. Induces the transcription of long intergenic non-coding RNA p21 (lincRNA-p21) and lincRNA- Mkln1. LincRNA-p21 participates in TP53-dependent transcriptional repression leading to apoptosis and seem to have to effect on cell-cycle regulation. Implicated in Notch signaling cross-over. Prevents CDK7 kinase activity when associated to CAK complex in response to DNA damage, thus stopping cell cycle progression. Isoform 2 enhances the transactivation activity of isoform 1 from some but not all TP53-inducible promoters. Isoform 4 suppresses transactivation activity and impairs growth suppression mediated by isoform 1. Isoform 7 inhibits isoform 1-mediated apoptosis. [The UniProt Consortium]

Rabbit IgG SR: human, mouse, rat
Immunogen: Phosphopeptide corresponding to a region of the mouse p53 protein surrounding serine 389. Sequence is conserved in rat.
USBio
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10 blots

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588 €

P1001-27C2.25
ELISA, WB Erklärungen der Abkürzungen ansehen.
Rabbit IgG SR: human
Immunogen: Synthetic phosphopeptide (EGPDpSD) corresponding to human p53 at the phosphorylated site of Serine 392.
USBio
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25 µg

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411 €

P1001-27D.100
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ELISA, WB, IP Erklärungen der Abkürzungen ansehen.
MW: 53 kD
Rabbit SR: human, monkey, mouse, rat
USBio
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100 µl

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528 €

P1001-27D3.100
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WB, IP, ICC, FC Erklärungen der Abkürzungen ansehen.
Rabbit SR: human
Immunogen: synthetic peptide
USBio
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100 µl

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537 €

P1001-27D4.500
FC, IF Erklärungen der Abkürzungen ansehen.
Mouse IgG SR: human
Immunogen: Synthetic phosphopeptide (KLH-coupled) corresponding to residues surrounding Ser15 of human p53. Conjugated to Alexa Fluor? 488 under optimal conditions with an F/P ratio of 2-6.
USBio
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500 µl

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509 €

P1001-27D5.25
WB Erklärungen der Abkürzungen ansehen.
Rabbit IgG SR: human
Immunogen: Synthetic peptide corresponding to human p53, phosphorylated at serine 15 (PPLpSQET).
USBio
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25 µg

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411 €

P1001-27E.100
related products

ELISA, WB, IP, ICC Erklärungen der Abkürzungen ansehen.
MW: 53 kD
Rabbit SR: hamster, human, monkey, mouse
USBio
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100 µl

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528 €

P1001-27E5.100
related products

WB, IP, IHC, ICC Erklärungen der Abkürzungen ansehen.
Acts as a tumor suppressor in many tumor types. induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Implicated in Notch signaling cross-over. Prevents CDK7 kinase activity when associated to CAK complex in response to DNA damage, thus stopping cell cycle progression. Isoform 2 enhances the transactivation activity of isoform 1 from some but not all TP53-inducible promoters. Isoform 4 suppresses transactivation activity and impairs growth suppression mediated by isoform 1. Isoform 7 inhibits isoform 1-mediated apoptosis. [The UniProt Consortium]

Rabbit IgG SR: human
Immunogen: Synthetic peptide corresponding the area encompassing and including phosphorylated Ser of human p53. Cellular Localization: Cytoplasm. Nucleus. Endoplasmic reticulum.
USBio
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100 µl

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628 €

P1001-27E6.25
WB Erklärungen der Abkürzungen ansehen.
Rabbit IgG SR: human
Immunogen: Synthetic peptide (MEEPQpSDPSVEP-NH2) corresponding to human p53 at the phosphorylated site of Serine 6.
USBio
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25 µg

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411 €

P1001-27F.100
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ELISA, WB, ICC, FC, IF Erklärungen der Abkürzungen ansehen.
MW: 53
Mouse IgG1 SR: human
USBio
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100 µl

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527 €

P1001-27G.100
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ELISA, WB Erklärungen der Abkürzungen ansehen.
MW: 53 kD
Rabbit SR: human, mouse
USBio
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100 µl

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528 €

P1001-27G2.25
ELISA, WB Erklärungen der Abkürzungen ansehen.
Rabbit IgG SR: human
Immunogen: Synthetic phosphopeptide (ETFpSDLW) corresponding to human p53 at the phosphorylated site of Serine 20.
USBio
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25 µg

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411 €

P1001-27H.100
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ELISA, WB, IP, ICC Erklärungen der Abkürzungen ansehen.
MW: 53 kD
Rabbit SR: human, monkey, mouse
USBio
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100 µl

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528 €

P1001-27H4.25
WB Erklärungen der Abkürzungen ansehen.
Rabbit IgG SR: human
Immunogen: Synthetic peptide (SDPpSVEP) corresponding to human p53 at the phosphorylated site of Serine 9.
USBio
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25 µg

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411 €

P1001-27J.100
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ELISA, WB, IP, ICC Erklärungen der Abkürzungen ansehen.
MW: 53 kD
Rabbit SR: human, monkey
USBio
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100 µl

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528 €

P1001-27J2.25
Gel Erklärungen der Abkürzungen ansehen.
Rabbit SR: human
Immunogen: Synthetic phosphopeptide (PLPpSQAM) corresponding to human p53 at the phosphorylated site of Serine 20.
USBio
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25 µg

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411 €

P1001-27K1-AP.200
neu

ELISA, WB, IHC Erklärungen der Abkürzungen ansehen.
Rabbit IgG SR: human
Immunogen: Synthetic phosphopeptide corresponding to amino acid residues surrounding Ser20 of human p53 (KLH).
USBio
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200 µl

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604 €

P1001-27K1-APC.200
neu

ELISA, WB, IHC Erklärungen der Abkürzungen ansehen.
Rabbit IgG SR: human
Immunogen: Synthetic phosphopeptide corresponding to amino acid residues surrounding Ser20 of human p53 (KLH).
USBio
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200 µl

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604 €

P1001-27K1-FITC.200
neu

ELISA, WB, IHC Erklärungen der Abkürzungen ansehen.
Rabbit IgG SR: human
Immunogen: Synthetic phosphopeptide corresponding to amino acid residues surrounding Ser20 of human p53 (KLH).
USBio
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200 µl

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604 €

P1001-27K1-HRP.200
neu

ELISA, WB, IHC Erklärungen der Abkürzungen ansehen.
Rabbit IgG SR: human
Immunogen: Synthetic phosphopeptide corresponding to amino acid residues surrounding Ser20 of human p53 (KLH).
USBio
Icon Datasheet
200 µl

Buy Bulk

604 €

P1001-27K1-PE.200
neu

ELISA, WB, IHC Erklärungen der Abkürzungen ansehen.
Rabbit IgG SR: human
Immunogen: Synthetic phosphopeptide corresponding to amino acid residues surrounding Ser20 of human p53 (KLH).
USBio
Icon Datasheet
200 µl

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604 €

P1001-27K1.200
related products

ELISA, WB, IHC Erklärungen der Abkürzungen ansehen.
Acts as a tumor suppressor in many tumor types. induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Implicated in Notch signaling cross-over. Prevents CDK7 kinase activity when associated to CAK complex in response to DNA damage, thus stopping cell cycle progression. Isoform 2 enhances the transactivation activity of isoform 1 from some but not all TP53-inducible promoters. Isoform 4 suppresses transactivation activity and impairs growth suppression mediated by isoform 1. Isoform 7 inhibits isoform 1-mediated apoptosis. [The UniProt Consortium]

Rabbit IgG SR: human
Immunogen: Synthetic phosphopeptide corresponding to amino acid residues surrounding S20 of human p53 (KLH).
USBio
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200 µl

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521 €

P1001-27K2-AP.200
neu

ELISA, WB, IHC, Gel Erklärungen der Abkürzungen ansehen.
Rabbit IgG SR: human
Immunogen: Synthetic phosphopeptide corresponding to amino acid residues surrounding Ser315 of human p53 (KLH).
USBio
Icon Datasheet
200 µl

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604 €

P1001-27K2-APC.200
neu

ELISA, WB, IHC, Gel Erklärungen der Abkürzungen ansehen.
Rabbit IgG SR: human
Immunogen: Synthetic phosphopeptide corresponding to amino acid residues surrounding Ser315 of human p53 (KLH).
USBio
Icon Datasheet
200 µl

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604 €

P1001-27K2-FITC.200
neu

ELISA, WB, IHC, Gel Erklärungen der Abkürzungen ansehen.
Rabbit IgG SR: human
Immunogen: Synthetic phosphopeptide corresponding to amino acid residues surrounding Ser315 of human p53 (KLH).
USBio
Icon Datasheet
200 µl

Buy Bulk

604 €

P1001-27K2-HRP.200
neu

ELISA, WB, IHC, Gel Erklärungen der Abkürzungen ansehen.
Rabbit IgG SR: human
Immunogen: Synthetic phosphopeptide corresponding to amino acid residues surrounding Ser315 of human p53 (KLH).
USBio
Icon Datasheet
200 µl

Buy Bulk

604 €

P1001-27K2-PE.200
neu

ELISA, WB, IHC, Gel Erklärungen der Abkürzungen ansehen.
Rabbit IgG SR: human
Immunogen: Synthetic phosphopeptide corresponding to amino acid residues surrounding Ser315 of human p53 (KLH).
USBio
Icon Datasheet
200 µl

Buy Bulk

604 €

P1001-27K2.200
related products

ELISA, WB, IHC, Gel Erklärungen der Abkürzungen ansehen.
Acts as a tumor suppressor in many tumor types. induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Implicated in Notch signaling cross-over. Prevents CDK7 kinase activity when associated to CAK complex in response to DNA damage, thus stopping cell cycle progression. Isoform 2 enhances the transactivation activity of isoform 1 from some but not all TP53-inducible promoters. Isoform 4 suppresses transactivation activity and impairs growth suppression mediated by isoform 1. Isoform 7 inhibits isoform 1-mediated apoptosis. [The UniProt Consortium]

Rabbit IgG SR: human
Immunogen: Synthetic phosphopeptide corresponding to amino acid residues surrounding S315 of human p53 (KLH).
USBio
Icon Datasheet
200 µl

Buy Bulk

521 €

P1001-27L-AP.200
neu

ELISA, WB, IHC Erklärungen der Abkürzungen ansehen.
Rabbit IgG SR: human
Immunogen: Synthetic phosphopeptide corresponding to amino acid residues surrounding Ser376 of human p53 (KLH).
USBio
Icon Datasheet
200 µl

Buy Bulk

604 €

P1001-27L-APC.200
neu

ELISA, WB, IHC Erklärungen der Abkürzungen ansehen.
Rabbit IgG SR: human
Immunogen: Synthetic phosphopeptide corresponding to amino acid residues surrounding Ser376 of human p53 (KLH).
USBio
Icon Datasheet
200 µl

Buy Bulk

604 €

P1001-27L-Biotin.200
neu

ELISA, WB, IHC Erklärungen der Abkürzungen ansehen.
Rabbit IgG SR: human
Immunogen: Synthetic phosphopeptide corresponding to amino acid residues surrounding Ser376 of human p53 (KLH).
USBio
Icon Datasheet
200 µl

Buy Bulk

604 €

P1001-27L-FITC.200
neu

ELISA, WB, IHC Erklärungen der Abkürzungen ansehen.
Rabbit IgG SR: human
Immunogen: Synthetic phosphopeptide corresponding to amino acid residues surrounding Ser376 of human p53 (KLH).
USBio
Icon Datasheet
200 µl

Buy Bulk

604 €

P1001-27L-HRP.200
neu

ELISA, WB, IHC Erklärungen der Abkürzungen ansehen.
Rabbit IgG SR: human
Immunogen: Synthetic phosphopeptide corresponding to amino acid residues surrounding Ser376 of human p53 (KLH).
USBio
Icon Datasheet
200 µl

Buy Bulk

604 €

P1001-27L-PE.200
neu

ELISA, WB, IHC Erklärungen der Abkürzungen ansehen.
Rabbit IgG SR: human
Immunogen: Synthetic phosphopeptide corresponding to amino acid residues surrounding Ser376 of human p53 (KLH).
USBio
Icon Datasheet
200 µl

Buy Bulk

604 €

P1001-27L.200
related products

ELISA, WB, IHC Erklärungen der Abkürzungen ansehen.
Acts as a tumor suppressor in many tumor types. induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Implicated in Notch signaling cross-over. Prevents CDK7 kinase activity when associated to CAK complex in response to DNA damage, thus stopping cell cycle progression. Isoform 2 enhances the transactivation activity of isoform 1 from some but not all TP53-inducible promoters. Isoform 4 suppresses transactivation activity and impairs growth suppression mediated by isoform 1. Isoform 7 inhibits isoform 1-mediated apoptosis. [The UniProt Consortium]

Rabbit IgG SR: human
Immunogen: Synthetic phosphopeptide corresponding to amino acid residues surrounding S376 of human p53 (KLH).
USBio
Icon Datasheet
200 µl

Buy Bulk

521 €

P1001-27L3-AP.200
neu

ELISA, WB, IHC, Gel Erklärungen der Abkürzungen ansehen.
Rabbit IgG SR: human, mouse
Immunogen: Synthetic phosphopeptide corresponding to amino acid residues surrounding Thr18 of human p53 (KLH).
USBio
Icon Datasheet
200 µl

Buy Bulk

604 €

P1001-27L3-APC.200
neu

ELISA, WB, IHC, Gel Erklärungen der Abkürzungen ansehen.
Rabbit IgG SR: human, mouse
Immunogen: Synthetic phosphopeptide corresponding to amino acid residues surrounding Thr18 of human p53 (KLH).
USBio
Icon Datasheet
200 µl

Buy Bulk

604 €

P1001-27L3-FITC.200
neu

ELISA, WB, IHC, Gel Erklärungen der Abkürzungen ansehen.
Rabbit IgG SR: human, mouse
Immunogen: Synthetic phosphopeptide corresponding to amino acid residues surrounding Thr18 of human p53 (KLH).
USBio
Icon Datasheet
200 µl

Buy Bulk

604 €

P1001-27L3-HRP.200
neu

ELISA, WB, IHC, Gel Erklärungen der Abkürzungen ansehen.
Rabbit IgG SR: human, mouse
Immunogen: Synthetic phosphopeptide corresponding to amino acid residues surrounding Thr18 of human p53 (KLH).
USBio
Icon Datasheet
200 µl

Buy Bulk

604 €

P1001-27L3-PE.200
neu

ELISA, WB, IHC, Gel Erklärungen der Abkürzungen ansehen.
Rabbit IgG SR: human, mouse
Immunogen: Synthetic phosphopeptide corresponding to amino acid residues surrounding Thr18 of human p53 (KLH).
USBio
Icon Datasheet
200 µl

Buy Bulk

604 €

P1001-27L3.200
related products

ELISA, WB, IHC, Gel Erklärungen der Abkürzungen ansehen.
Acts as a tumor suppressor in many tumor types. induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Implicated in Notch signaling cross-over. Prevents CDK7 kinase activity when associated to CAK complex in response to DNA damage, thus stopping cell cycle progression. Isoform 2 enhances the transactivation activity of isoform 1 from some but not all TP53-inducible promoters. Isoform 4 suppresses transactivation activity and impairs growth suppression mediated by isoform 1. Isoform 7 inhibits isoform 1-mediated apoptosis. [The UniProt Consortium]

Rabbit IgG SR: human, mouse
Immunogen: Synthetic phosphopeptide corresponding to amino acid residues surrounding T18 of human p53 (KLH).
USBio
Icon Datasheet
200 µl

Buy Bulk

521 €

P1001-27L5-AP.200
neu

ELISA, Gel Erklärungen der Abkürzungen ansehen.
Rabbit IgG SR: human
Immunogen: Synthetic phosphopeptide corresponding to amino acid residues surrounding Thr55 of human p53 (KLH).
USBio
Icon Datasheet
200 µl

Buy Bulk

604 €

P1001-27L5-APC.200
neu

ELISA, Gel Erklärungen der Abkürzungen ansehen.
Rabbit IgG SR: human
Immunogen: Synthetic phosphopeptide corresponding to amino acid residues surrounding Thr55 of human p53 (KLH).
USBio
Icon Datasheet
200 µl

Buy Bulk

604 €

P1001-27L5-FITC.200
neu

ELISA, Gel Erklärungen der Abkürzungen ansehen.
Rabbit IgG SR: human
Immunogen: Synthetic phosphopeptide corresponding to amino acid residues surrounding Thr55 of human p53 (KLH).
USBio
Icon Datasheet
200 µl

Buy Bulk

604 €

P1001-27L5-HRP.200
neu

ELISA, Gel Erklärungen der Abkürzungen ansehen.
Rabbit IgG SR: human
Immunogen: Synthetic phosphopeptide corresponding to amino acid residues surrounding Thr55 of human p53 (KLH).
USBio
Icon Datasheet
200 µl

Buy Bulk

604 €

P1001-27L5-PE.200
neu

ELISA, Gel Erklärungen der Abkürzungen ansehen.
Rabbit IgG SR: human
Immunogen: Synthetic phosphopeptide corresponding to amino acid residues surrounding Thr55 of human p53 (KLH).
USBio
Icon Datasheet
200 µl

Buy Bulk

604 €

P1001-27L5.200
ELISA, Gel Erklärungen der Abkürzungen ansehen.
Acts as a tumor suppressor in many tumor types. induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Implicated in Notch signaling cross-over. Prevents CDK7 kinase activity when associated to CAK complex in response to DNA damage, thus stopping cell cycle progression. Isoform 2 enhances the transactivation activity of isoform 1 from some but not all TP53-inducible promoters. Isoform 4 suppresses transactivation activity and impairs growth suppression mediated by isoform 1. Isoform 7 inhibits isoform 1-mediated apoptosis. [The UniProt Consortium]

Rabbit IgG SR: human
Immunogen: Synthetic phosphopeptide corresponding to amino acid residues surrounding T55 of human p53 (KLH).
USBio
Icon Datasheet
200 µl

Buy Bulk

521 €

P1001-27L6-AP.200
neu

ELISA, WB Erklärungen der Abkürzungen ansehen.
Rabbit IgG SR: human
Immunogen: Synthetic peptide selected from the C-terminal region of human p53 (KLH).
USBio
Icon Datasheet
200 µl

Buy Bulk

604 €

P1001-27L6-APC.200
neu

ELISA, WB Erklärungen der Abkürzungen ansehen.
Rabbit IgG SR: human
Immunogen: Synthetic peptide selected from the C-terminal region of human p53 (KLH).
USBio
Icon Datasheet
200 µl

Buy Bulk

604 €

P1001-27L6-FITC.200
neu

ELISA, WB Erklärungen der Abkürzungen ansehen.
Rabbit IgG SR: human
Immunogen: Synthetic peptide selected from the C-terminal region of human p53 (KLH).
USBio
Icon Datasheet
200 µl

Buy Bulk

604 €

P1001-27L6-HRP.200
neu

ELISA, WB Erklärungen der Abkürzungen ansehen.
Rabbit IgG SR: human
Immunogen: Synthetic peptide selected from the C-terminal region of human p53 (KLH).
USBio
Icon Datasheet
200 µl

Buy Bulk

604 €

P1001-27L6-PE.200
neu

ELISA, WB Erklärungen der Abkürzungen ansehen.
Rabbit IgG SR: human
Immunogen: Synthetic peptide selected from the C-terminal region of human p53 (KLH).
USBio
Icon Datasheet
200 µl

Buy Bulk

604 €

P1001-27L6.200
related products

ELISA, WB Erklärungen der Abkürzungen ansehen.
Acts as a tumor suppressor in many tumor types. induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Implicated in Notch signaling cross-over. Prevents CDK7 kinase activity when associated to CAK complex in response to DNA damage, thus stopping cell cycle progression. Isoform 2 enhances the transactivation activity of isoform 1 from some but not all TP53-inducible promoters. Isoform 4 suppresses transactivation activity and impairs growth suppression mediated by isoform 1. Isoform 7 inhibits isoform 1-mediated apoptosis. [The UniProt Consortium]

Rabbit IgG SR: human
Immunogen: Synthetic peptide selected from the C-terminal region of human p53 (KLH).
USBio
Icon Datasheet
200 µl

Buy Bulk

521 €

P1001-27M-AP.200
neu

ELISA, WB Erklärungen der Abkürzungen ansehen.
Rabbit IgG SR: human
Immunogen: Synthetic peptide corresponding to amino acid residues surrounding T55 of human TP53 (KLH).
USBio
Icon Datasheet
200 µl

Buy Bulk

604 €

P1001-27M-APC.200
neu

ELISA, WB Erklärungen der Abkürzungen ansehen.
Rabbit IgG SR: human
Immunogen: Synthetic peptide corresponding to amino acid residues surrounding T55 of human TP53 (KLH).
USBio
Icon Datasheet
200 µl

Buy Bulk

604 €

P1001-27M-Biotin.200
neu

ELISA, WB Erklärungen der Abkürzungen ansehen.
Rabbit IgG SR: human
Immunogen: Synthetic peptide corresponding to amino acid residues surrounding T55 of human TP53 (KLH).
USBio
Icon Datasheet
200 µl

Buy Bulk

604 €

P1001-27M-FITC.200
neu

ELISA, WB Erklärungen der Abkürzungen ansehen.
Rabbit IgG SR: human
Immunogen: Synthetic peptide corresponding to amino acid residues surrounding T55 of human TP53 (KLH).
USBio
Icon Datasheet
200 µl

Buy Bulk

604 €

P1001-27M-HRP.200
neu

ELISA, WB Erklärungen der Abkürzungen ansehen.
Rabbit IgG SR: human
Immunogen: Synthetic peptide corresponding to amino acid residues surrounding T55 of human TP53 (KLH).
USBio
Icon Datasheet
200 µl

Buy Bulk

604 €

P1001-27M-PE.200
neu

ELISA, WB Erklärungen der Abkürzungen ansehen.
Rabbit IgG SR: human
Immunogen: Synthetic peptide corresponding to amino acid residues surrounding T55 of human TP53 (KLH).
USBio
Icon Datasheet
200 µl

Buy Bulk

604 €

P1001-27M.200
related products

ELISA, WB Erklärungen der Abkürzungen ansehen.
Acts as a tumor suppressor in many tumor types. induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Implicated in Notch signaling cross-over. Prevents CDK7 kinase activity when associated to CAK complex in response to DNA damage, thus stopping cell cycle progression. Isoform 2 enhances the transactivation activity of isoform 1 from some but not all TP53-inducible promoters. Isoform 4 suppresses transactivation activity and impairs growth suppression mediated by isoform 1. Isoform 7 inhibits isoform 1-mediated apoptosis. [The UniProt Consortium]

Rabbit IgG SR: human
Immunogen: Synthetic peptide corresponding to amino acid residues surrounding T55 of human TP53 (KLH).
USBio
Icon Datasheet
200 µl

Buy Bulk

521 €

P1001-27M1-AP.200
neu

ELISA, WB Erklärungen der Abkürzungen ansehen.
Rabbit IgG SR: human
Immunogen: Synthetic peptide corresponding to amino acid residues surrounding S15 of human TP53 (KLH).
USBio
Icon Datasheet
200 µl

Buy Bulk

604 €

P1001-27M1-APC.200
neu

ELISA, WB Erklärungen der Abkürzungen ansehen.
Rabbit IgG SR: human
Immunogen: Synthetic peptide corresponding to amino acid residues surrounding S15 of human TP53 (KLH).
USBio
Icon Datasheet
200 µl

Buy Bulk

604 €

P1001-27M1-FITC.200
neu

ELISA, WB Erklärungen der Abkürzungen ansehen.
Rabbit IgG SR: human
Immunogen: Synthetic peptide corresponding to amino acid residues surrounding S15 of human TP53 (KLH).
USBio
Icon Datasheet
200 µl

Buy Bulk

604 €

P1001-27M1-HRP.200
neu

ELISA, WB Erklärungen der Abkürzungen ansehen.
Rabbit IgG SR: human
Immunogen: Synthetic peptide corresponding to amino acid residues surrounding S15 of human TP53 (KLH).
USBio
Icon Datasheet
200 µl

Buy Bulk

604 €

P1001-27M1-PE.200
neu

ELISA, WB Erklärungen der Abkürzungen ansehen.
Rabbit IgG SR: human
Immunogen: Synthetic peptide corresponding to amino acid residues surrounding S15 of human TP53 (KLH).
USBio
Icon Datasheet
200 µl

Buy Bulk

604 €

P1001-27M1.200
related products

ELISA, WB Erklärungen der Abkürzungen ansehen.
Acts as a tumor suppressor in many tumor types. induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Implicated in Notch signaling cross-over. Prevents CDK7 kinase activity when associated to CAK complex in response to DNA damage, thus stopping cell cycle progression. Isoform 2 enhances the transactivation activity of isoform 1 from some but not all TP53-inducible promoters. Isoform 4 suppresses transactivation activity and impairs growth suppression mediated by isoform 1. Isoform 7 inhibits isoform 1-mediated apoptosis. [The UniProt Consortium]

Rabbit IgG SR: human
Immunogen: Synthetic peptide corresponding to amino acid residues surrounding S15 of human TP53 (KLH).
USBio
Icon Datasheet
200 µl

Buy Bulk

521 €

P1001-27M4-AP.200
neu

ELISA, WB, IHC Erklärungen der Abkürzungen ansehen.
Rabbit IgG SR: human
Immunogen: Synthetic peptide corresponding to amino acid residues surrounding S315 of human TP53 (KLH).
USBio
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200 µl

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604 €

P1001-27M4-APC.200
neu

ELISA, WB, IHC Erklärungen der Abkürzungen ansehen.
Rabbit IgG SR: human
Immunogen: Synthetic peptide corresponding to amino acid residues surrounding S315 of human TP53 (KLH).
USBio
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200 µl

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604 €

P1001-27M4-FITC.200
neu

ELISA, WB, IHC Erklärungen der Abkürzungen ansehen.
Rabbit IgG SR: human
Immunogen: Synthetic peptide corresponding to amino acid residues surrounding S315 of human TP53 (KLH).
USBio
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200 µl

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604 €

P1001-27M4-HRP.200
neu

ELISA, WB, IHC Erklärungen der Abkürzungen ansehen.
Rabbit IgG SR: human
Immunogen: Synthetic peptide corresponding to amino acid residues surrounding S315 of human TP53 (KLH).
USBio
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200 µl

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604 €

P1001-27M4-PE.200
neu

ELISA, WB, IHC Erklärungen der Abkürzungen ansehen.
Rabbit IgG SR: human
Immunogen: Synthetic peptide corresponding to amino acid residues surrounding S315 of human TP53 (KLH).
USBio
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200 µl

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604 €

P1001-27M4.200
related products

ELISA, WB, IHC Erklärungen der Abkürzungen ansehen.
Acts as a tumor suppressor in many tumor types. induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Implicated in Notch signaling cross-over. Prevents CDK7 kinase activity when associated to CAK complex in response to DNA damage, thus stopping cell cycle progression. Isoform 2 enhances the transactivation activity of isoform 1 from some but not all TP53-inducible promoters. Isoform 4 suppresses transactivation activity and impairs growth suppression mediated by isoform 1. Isoform 7 inhibits isoform 1-mediated apoptosis. [The UniProt Consortium]

Rabbit IgG SR: human
Immunogen: Synthetic peptide corresponding to amino acid residues surrounding S315 of human TP53 (KLH).
USBio
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200 µl

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521 €

P1001-27R.100
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Rabbit SR: human, rat
Immunogen: synthetic peptide
USBio
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100 µl

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537 €

P1001-27S.100
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Rabbit SR: human, rat
Immunogen: synthetic peptide
USBio
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100 µl

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586 €

P1001-27T1.1
WB, IHC, FC Erklärungen der Abkürzungen ansehen.
Mouse IgG1 SR: human
Immunogen: Human p53 beta galactosidase fusion.
USBio
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1 ml

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923 €

P1001-27U.100
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WB, IHC Erklärungen der Abkürzungen ansehen.
Mouse IgG1 SR: human, mouse
Immunogen: Phosphorylated synthetic peptide: HKKLMFKTEGPDSD, representing the C-terminus of the human protein (residues 380-393), of Human p53.
USBio
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100 µg

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596 €

P1001-27V.50
WB, Gel Erklärungen der Abkürzungen ansehen.
Rabbit IgG SR: human, mouse, rat
Immunogen: Synthetic peptide (KKGQSTS) corresponding to human p53 at C-terminal.
USBio
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50 µg

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411 €

P1001-27W.50
WB Erklärungen der Abkürzungen ansehen.
Rabbit IgG SR: human
Immunogen: Synthetic peptide (MEEPQSDPSVEP) corresponding to N-terminus of human p53.
USBio
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50 µg

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454 €

P1001-27W1.50
ELISA, WB Erklärungen der Abkürzungen ansehen.
Rabbit IgG SR: human, monkey
Immunogen: Synthetic peptide corresponding to aa surrounding Serine 46 of human p53.
USBio
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50 µg

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454 €

P1001-27W2.50
ELISA, WB Erklärungen der Abkürzungen ansehen.
Rabbit IgG SR: human
Immunogen: Synthetic peptide (MEEPQSDPSVEP) corresponding to N-terminus of human p53.
USBio
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50 µg

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454 €

P1001-27W3.50
WB Erklärungen der Abkürzungen ansehen.
Rabbit IgG SR: human
Immunogen: Synthetic peptide (MEEPQSDPSVEP) corresponding to N-terminus of human p53.
USBio
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50 µg

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548 €

P1001-27W4.1
WB, IHC Erklärungen der Abkürzungen ansehen.
Mouse IgG2,a SR: human
Immunogen: Recombinant human wild-type p53 protein.
USBio
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1 ml

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845 €

P1001-27X.50
WB, Gel Erklärungen der Abkürzungen ansehen.
Rabbit SR: human, monkey
Immunogen: Synthetic peptide (ETFSDLW) corresponding to aa surrounding Serine 20 of human p53.
USBio
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50 µg

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454 €

P1001-27Y.50
WB Erklärungen der Abkürzungen ansehen.
Rabbit IgG SR: human, monkey
Immunogen: Synthetic peptide (PLPSQAM) corresponding to aa surrounding Serine 37 of human p53.
USBio
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50 µg

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454 €

P1001-27Z.50
WB Erklärungen der Abkürzungen ansehen.
Rabbit IgG SR: human, monkey
Immunogen: Synthetic peptide (EGPDSD) corresponding to aa surrounding Serine 392 of human p53.
USBio
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50 µg

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454 €

P1001-28.100
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WB, ICC Erklärungen der Abkürzungen ansehen.
Rabbit SR: human
USBio
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100 µl

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528 €

P1001-28A.100
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ELISA, WB, IP, IHC, ICC Erklärungen der Abkürzungen ansehen.
Acts as a tumor suppressor in many tumor types. induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Implicated in Notch signaling cross-over. Prevents CDK7 kinase activity when associated to CAK complex in response to DNA damage, thus stopping cell cycle progression. Isoform 2 enhances the transactivation activity of isoform 1 from some but not all TP53-inducible promoters. Isoform 4 suppresses transactivation activity and impairs growth suppression mediated by isoform 1. Isoform 7 inhibits isoform 1-mediated apoptosis. [The UniProt Consortium]

Purity: Supernatant
Rabbit IgG SR: human, mouse, rat
Immunogen: A synthetic phospho-peptide corresponding to residues surrounding serine 46 of human p53 protein.
USBio
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100 µl

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586 €

P1001-28B.100
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WB, ICC Erklärungen der Abkürzungen ansehen.
Purity: Supernatant
Rabbit IgG SR: human
Immunogen: A phospho specific peptide corresponding to residues surrounding serine 33 of human p53.
USBio
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100 µl

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537 €

P1001-28C.200
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WB, IP Erklärungen der Abkürzungen ansehen.
Rabbit SR: human
Immunogen: KLH-conjugated, synthetic peptide corresponding to aa367-379 of human p53 (SHLKSK[AcK]GQSTSR, where AcK denotes acetyllysine).
USBio
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200 µl

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512 €

P1001-28E.1
ELISA, IP, IHC, FC, IF Erklärungen der Abkürzungen ansehen.
Mouse SR: human
USBio
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1 mg

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1322 €

P1001-28E.100
ELISA, IP, IHC, FC, IF Erklärungen der Abkürzungen ansehen.
Mouse SR: human
USBio
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100 µg

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436 €

P1001-28E.500
ELISA, IP, IHC, FC, IF Erklärungen der Abkürzungen ansehen.
Mouse SR: human
USBio
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500 µg

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731 €

P1001-28F.25
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Mouse SR: human
USBio
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25 µg

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582 €

P1001-28G.250
IHC, ICC, IF Erklärungen der Abkürzungen ansehen.
Rabbit SR: human
USBio
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250 µl

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663 €

P1001-28H-AP.100
neu

ELISA, WB, IHC, IF Erklärungen der Abkürzungen ansehen.
Mouse IgG1 SR: human
Immunogen: Recombinant protein corresponding to aa94-202 of human TP53.
USBio
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100 µl

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788 €

P1001-28H-APC.100
neu

ELISA, WB, IHC, IF Erklärungen der Abkürzungen ansehen.
Mouse IgG1 SR: human
Immunogen: Recombinant protein corresponding to aa94-202 of human TP53.
USBio
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100 µl

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788 €

P1001-28H-Biotin.100
neu

ELISA, WB, IHC, IF Erklärungen der Abkürzungen ansehen.
Mouse IgG1 SR: human
Immunogen: Recombinant protein corresponding to aa94-202 of human TP53.
USBio
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100 µl

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788 €

P1001-28H-FITC.100
neu

ELISA, WB, IHC, IF Erklärungen der Abkürzungen ansehen.
Mouse IgG1 SR: human
Immunogen: Recombinant protein corresponding to aa94-202 of human TP53.
USBio
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100 µl

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788 €

P1001-28H-HRP.100
neu

ELISA, WB, IHC, IF Erklärungen der Abkürzungen ansehen.
Mouse IgG1 SR: human
Immunogen: Recombinant protein corresponding to aa94-202 of human TP53.
USBio
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100 µl

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788 €

P1001-28H-PE.100
neu

ELISA, WB, IHC, IF Erklärungen der Abkürzungen ansehen.
Mouse IgG1 SR: human
Immunogen: Recombinant protein corresponding to aa94-202 of human TP53.
USBio
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100 µl

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788 €

P1001-28J.500
IP, IHC, ICC, FC, IF Erklärungen der Abkürzungen ansehen.
Acts as a tumor suppressor in many tumor types. induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Implicated in Notch signaling cross-over. Prevents CDK7 kinase activity when associated to CAK complex in response to DNA damage, thus stopping cell cycle progression. Isoform 2 enhances the transactivation activity of isoform 1 from some but not all TP53-inducible promoters. Isoform 4 suppresses transactivation activity and impairs growth suppression mediated by isoform 1. Isoform 7 inhibits isoform 1-mediated apoptosis. [The UniProt Consortium]

Mouse IgG2a SR: human, monkey
Immunogen: Recombinant corresponding to wild type p53 protein. Cellular Localization: Nuclear.
USBio
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500 µl

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676 €

P1001-28K.250
IHC Erklärungen der Abkürzungen ansehen.
Acts as a tumor suppressor in many tumor types. induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Implicated in Notch signaling cross-over. Prevents CDK7 kinase activity when associated to CAK complex in response to DNA damage, thus stopping cell cycle progression. Isoform 2 enhances the transactivation activity of isoform 1 from some but not all TP53-inducible promoters. Isoform 4 suppresses transactivation activity and impairs growth suppression mediated by isoform 1. Isoform 7 inhibits isoform 1-mediated apoptosis. [The UniProt Consortium]

Rabbit IgG SR: human
Immunogen: Recombinant corresponding to human full-length wild type p53 protein. Cellular Localization: Nuclear.
USBio
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250 µl

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596 €

P1001-28N.100
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WB, IP, IHC Erklärungen der Abkürzungen ansehen.
Mouse IgG2a SR: human
Immunogen: Recombinant protein, corresponding to amino acids 10-16 of Human p53.
USBio
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100 µg

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596 €

P1001-28S.50
related products

WB Erklärungen der Abkürzungen ansehen.
Acts as a tumor suppressor in many tumor types. induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Implicated in Notch signaling cross-over. Prevents CDK7 kinase activity when associated to CAK complex in response to DNA damage, thus stopping cell cycle progression. Isoform 2 enhances the transactivation activity of isoform 1 from some but not all TP53-inducible promoters. Isoform 4 suppresses transactivation activity and impairs growth suppression mediated by isoform 1. Isoform 7 inhibits isoform 1-mediated apoptosis. [The UniProt Consortium]

Rabbit IgG SR: human
Immunogen: Synthetic phosphopeptide corresponding to human p53 around the phosphorylation site of serine 46 (M-L-SP-P-D).
USBio
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50 µg

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560 €

P1001-28W.50
related products

WB, IHC Erklärungen der Abkürzungen ansehen.
Acts as a tumor suppressor in many tumor types. induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Implicated in Notch signaling cross-over. Prevents CDK7 kinase activity when associated to CAK complex in response to DNA damage, thus stopping cell cycle progression. Isoform 2 enhances the transactivation activity of isoform 1 from some but not all TP53-inducible promoters. Isoform 4 suppresses transactivation activity and impairs growth suppression mediated by isoform 1. Isoform 7 inhibits isoform 1-mediated apoptosis. [The UniProt Consortium]

Rabbit IgG SR: human
Immunogen: Synthetic phosphopeptide corresponding to human p53 around the phosphorylation site of serine 315 (S-S-SP-P-Q).
USBio
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50 µg

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560 €

P1001-28Y.100
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WB, IP Erklärungen der Abkürzungen ansehen.
Rabbit SR: human
Immunogen: The epitope recognized maps to a region between residues 50-100 of human tumor protein p53 using the SwissProt entry P04637 (GeneID 7157).
USBio
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100 µl

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726 €

P1001-28Z.100
related products

WB, IP Erklärungen der Abkürzungen ansehen.
Rabbit SR: human
Immunogen: The epitope recognized maps to a region between residues 325-375 of human tumor protein p53 using the SwissProt entry P04637 (GeneID 7157).
USBio
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100 µl

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726 €

P1001-28Z1.100
related products

WB Erklärungen der Abkürzungen ansehen.
Acts as a tumor suppressor in many tumor types. induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Implicated in Notch signaling cross-over. Prevents CDK7 kinase activity when associated to CAK complex in response to DNA damage, thus stopping cell cycle progression. Isoform 2 enhances the transactivation activity of isoform 1 from some but not all TP53-inducible promoters. Isoform 4 suppresses transactivation activity and impairs growth suppression mediated by isoform 1. Isoform 7 inhibits isoform 1-mediated apoptosis. [The UniProt Consortium]

Rabbit IgG SR: human
Immunogen: Synthetic non-phosphopeptide corresponding to human p53 around the phosphorylation site of serine 46 (M-L-SP-P-D).
USBio
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100 µg

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625 €

P1001-28Z2.100
related products

WB Erklärungen der Abkürzungen ansehen.
Acts as a tumor suppressor in many tumor types. induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Implicated in Notch signaling cross-over. Prevents CDK7 kinase activity when associated to CAK complex in response to DNA damage, thus stopping cell cycle progression. Isoform 2 enhances the transactivation activity of isoform 1 from some but not all TP53-inducible promoters. Isoform 4 suppresses transactivation activity and impairs growth suppression mediated by isoform 1. Isoform 7 inhibits isoform 1-mediated apoptosis. [The UniProt Consortium]

Rabbit IgG SR: human
Immunogen: Synthetic non-phosphopeptide corresponding to human p53 around the phosphorylation site of serine 315 (S-S-SP-P-Q).
USBio
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100 µg

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625 €

P1001-29C.100
ELISA, WB, IP, IHC Erklärungen der Abkürzungen ansehen.
Mouse IgG1 SR: bovine, chicken, hamster, human, monkey, mouse, rat
USBio
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100 µg

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483 €

P1001-29D2.500
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ELISA, WB, IHC Erklärungen der Abkürzungen ansehen.
Rabbit IgG SR: human
Immunogen: recombinant human full-length wild type p53 protein.
USBio
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500 µl

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423 €

P1001-29F1.50
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WB, IHC Erklärungen der Abkürzungen ansehen.
Mouse IgG1 SR: human
Immunogen: Modified synthetic peptide (RHKKLMFKTEGPDS*D) corresponding to amino acids 378-393 of human p53.
USBio
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50 µg

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703 €

P1001-29G.100
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WB, IP Erklärungen der Abkürzungen ansehen.
Rabbit SR: human
Immunogen: The epitope recognized maps to a region between residues 375-393 (C-terminus)of human tumor protein p53 using the SwissProt entry P04637 (GeneID 7157).
USBio
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100 µl

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726 €

P1001-29N.100
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WB, IHC, ICC, FC Erklärungen der Abkürzungen ansehen.
Mouse IgG2a SR: human, mouse
Immunogen: Synthetic peptide, corresponding to amino acids 20-25 of Human p53.
USBio
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100 µg

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611 €

P1001-29P.500
IHC Erklärungen der Abkürzungen ansehen.
Porcine IgG SR: human, mouse, rat
Immunogen: Recombinant full length wild type p53 protein.
USBio
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500 µl

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596 €

P1001-30.200
related products

WB, IP Erklärungen der Abkürzungen ansehen.
Mouse IgG2a SR: human
USBio
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200 µl

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535 €

P1001-30A1.100
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WB, IHC, ICC, FC Erklärungen der Abkürzungen ansehen.
Mouse SR: human
Immunogen: Synthetic peptide corresponding to aa 16-25 of wild-type and mutant p53.
USBio
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100 µg

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405 €

P1001-30B.200
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WB Erklärungen der Abkürzungen ansehen.
Rabbit SR: human
USBio
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200 µl

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427 €

P1001-30C.200
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WB Erklärungen der Abkürzungen ansehen.
Rabbit IgG SR: human
USBio
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200 µl

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535 €

P1001-30C1.100
related products

WB, ICC Erklärungen der Abkürzungen ansehen.
Purity: Supernatant
Rabbit IgG SR: human
Immunogen: A synthetic acetylated peptide corresponding to residues surrounding K382 of human p53.
USBio
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100 µl

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586 €

P1001-30C2.100
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WB, IHC, ICC Erklärungen der Abkürzungen ansehen.
Purity: Supernatant
Rabbit IgG SR: human
Immunogen: A synthetic acetylated peptide corresponding to residues surrounding Ly373 of human p53.
USBio
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100 µl

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537 €

P1001-30D.200
ELISA Erklärungen der Abkürzungen ansehen.
Mouse IgG1 kappa SR: human, mouse
Immunogen: Beta galactosidase-human p53 fusion protein.
USBio
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200 µg

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397 €

P1001-30E.200
ELISA Erklärungen der Abkürzungen ansehen.
Mouse IgG1 kappa SR: human
Immunogen: p53 beta galactosidase fusion protein.
USBio
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200 µg

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408 €

P1001-30F.50
related products

WB Erklärungen der Abkürzungen ansehen.
Rabbit IgG SR: human
Immunogen: Synthetic peptide corresponding to aa361-382 of human p53 conjugated to human thyroglobulin.
USBio
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50 µl

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566 €

P1001-30F1.100
WB Erklärungen der Abkürzungen ansehen.
Acts as a tumor suppressor in many tumor types. induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Implicated in Notch signaling cross-over. Prevents CDK7 kinase activity when associated to CAK complex in response to DNA damage, thus stopping cell cycle progression. Isoform 2 enhances the transactivation activity of isoform 1 from some but not all TP53-inducible promoters. Isoform 4 suppresses transactivation activity and impairs growth suppression mediated by isoform 1. Isoform 7 inhibits isoform 1-mediated apoptosis. [The UniProt Consortium]

Rabbit IgG SR: human
Immunogen: Synthetic non-phosphopeptide corresponding to human p53 around the phosphorylation site of serine 9 (D-P-SP-V-E).
USBio
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100 µg

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431 €

P1001-30F1.50
WB Erklärungen der Abkürzungen ansehen.
Acts as a tumor suppressor in many tumor types. induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Implicated in Notch signaling cross-over. Prevents CDK7 kinase activity when associated to CAK complex in response to DNA damage, thus stopping cell cycle progression. Isoform 2 enhances the transactivation activity of isoform 1 from some but not all TP53-inducible promoters. Isoform 4 suppresses transactivation activity and impairs growth suppression mediated by isoform 1. Isoform 7 inhibits isoform 1-mediated apoptosis. [The UniProt Consortium]

Rabbit IgG SR: human
Immunogen: Synthetic non-phosphopeptide corresponding to human p53 around the phosphorylation site of serine 9 (D-P-SP-V-E).
USBio
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50 µg

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333 €

P1001-30F2.100
WB, IHC, IF Erklärungen der Abkürzungen ansehen.
Acts as a tumor suppressor in many tumor types. induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Implicated in Notch signaling cross-over. Prevents CDK7 kinase activity when associated to CAK complex in response to DNA damage, thus stopping cell cycle progression. Isoform 2 enhances the transactivation activity of isoform 1 from some but not all TP53-inducible promoters. Isoform 4 suppresses transactivation activity and impairs growth suppression mediated by isoform 1. Isoform 7 inhibits isoform 1-mediated apoptosis. [The UniProt Consortium]

Rabbit IgG SR: human
Immunogen: Synthetic non-phosphopeptide corresponding to human p53 around the phosphorylation site of serine15 (P-L-SP-Q-E).
USBio
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100 µg

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431 €

P1001-30F2.50
WB, IHC, IF Erklärungen der Abkürzungen ansehen.
Acts as a tumor suppressor in many tumor types. induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Implicated in Notch signaling cross-over. Prevents CDK7 kinase activity when associated to CAK complex in response to DNA damage, thus stopping cell cycle progression. Isoform 2 enhances the transactivation activity of isoform 1 from some but not all TP53-inducible promoters. Isoform 4 suppresses transactivation activity and impairs growth suppression mediated by isoform 1. Isoform 7 inhibits isoform 1-mediated apoptosis. [The UniProt Consortium]

Rabbit IgG SR: human
Immunogen: Synthetic non-phosphopeptide corresponding to human p53 around the phosphorylation site of serine15 (P-L-SP-Q-E).
USBio
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50 µg

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333 €

P1001-30F3.100
WB Erklärungen der Abkürzungen ansehen.
Acts as a tumor suppressor in many tumor types. induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Implicated in Notch signaling cross-over. Prevents CDK7 kinase activity when associated to CAK complex in response to DNA damage, thus stopping cell cycle progression. Isoform 2 enhances the transactivation activity of isoform 1 from some but not all TP53-inducible promoters. Isoform 4 suppresses transactivation activity and impairs growth suppression mediated by isoform 1. Isoform 7 inhibits isoform 1-mediated apoptosis. [The UniProt Consortium]

Rabbit IgG SR: human
Immunogen: Synthetic non-phosphopeptide corresponding to human p53 around the phosphorylation site of threonine 18 (Q-E-TP-F-S).
USBio
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100 µg

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431 €

P1001-30F3.50
WB Erklärungen der Abkürzungen ansehen.
Acts as a tumor suppressor in many tumor types. induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Implicated in Notch signaling cross-over. Prevents CDK7 kinase activity when associated to CAK complex in response to DNA damage, thus stopping cell cycle progression. Isoform 2 enhances the transactivation activity of isoform 1 from some but not all TP53-inducible promoters. Isoform 4 suppresses transactivation activity and impairs growth suppression mediated by isoform 1. Isoform 7 inhibits isoform 1-mediated apoptosis. [The UniProt Consortium]

Rabbit IgG SR: human
Immunogen: Synthetic non-phosphopeptide corresponding to human p53 around the phosphorylation site of threonine 18 (Q-E-TP-F-S).
USBio
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50 µg

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333 €

P1001-30F4.100
WB Erklärungen der Abkürzungen ansehen.
Acts as a tumor suppressor in many tumor types. induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Implicated in Notch signaling cross-over. Prevents CDK7 kinase activity when associated to CAK complex in response to DNA damage, thus stopping cell cycle progression. Isoform 2 enhances the transactivation activity of isoform 1 from some but not all TP53-inducible promoters. Isoform 4 suppresses transactivation activity and impairs growth suppression mediated by isoform 1. Isoform 7 inhibits isoform 1-mediated apoptosis. [The UniProt Consortium]

Rabbit IgG SR: human, mouse
Immunogen: Synthetic non-phosphopeptide corresponding to human p53 around the phosphorylation site of serine 6 (P-Q-SP-D-P).
USBio
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100 µg

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431 €

P1001-30F4.50
WB Erklärungen der Abkürzungen ansehen.
Acts as a tumor suppressor in many tumor types. induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Implicated in Notch signaling cross-over. Prevents CDK7 kinase activity when associated to CAK complex in response to DNA damage, thus stopping cell cycle progression. Isoform 2 enhances the transactivation activity of isoform 1 from some but not all TP53-inducible promoters. Isoform 4 suppresses transactivation activity and impairs growth suppression mediated by isoform 1. Isoform 7 inhibits isoform 1-mediated apoptosis. [The UniProt Consortium]

Rabbit IgG SR: human, mouse
Immunogen: Synthetic non-phosphopeptide corresponding to human p53 around the phosphorylation site of serine 6 (P-Q-SP-D-P).
USBio
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50 µg

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333 €

P1001-30F5.100
WB Erklärungen der Abkürzungen ansehen.
Acts as a tumor suppressor in many tumor types. induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Implicated in Notch signaling cross-over. Prevents CDK7 kinase activity when associated to CAK complex in response to DNA damage, thus stopping cell cycle progression. Isoform 2 enhances the transactivation activity of isoform 1 from some but not all TP53-inducible promoters. Isoform 4 suppresses transactivation activity and impairs growth suppression mediated by isoform 1. Isoform 7 inhibits isoform 1-mediated apoptosis. [The UniProt Consortium]

Rabbit IgG SR: human
Immunogen: Synthetic non-phosphopeptide corresponding to human p53 around the phosphorylation site of serine 33 (V-L-SP-P-L).
USBio
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100 µg

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431 €

P1001-30F5.50
WB Erklärungen der Abkürzungen ansehen.
Acts as a tumor suppressor in many tumor types. induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Implicated in Notch signaling cross-over. Prevents CDK7 kinase activity when associated to CAK complex in response to DNA damage, thus stopping cell cycle progression. Isoform 2 enhances the transactivation activity of isoform 1 from some but not all TP53-inducible promoters. Isoform 4 suppresses transactivation activity and impairs growth suppression mediated by isoform 1. Isoform 7 inhibits isoform 1-mediated apoptosis. [The UniProt Consortium]

Rabbit IgG SR: human
Immunogen: Synthetic non-phosphopeptide corresponding to human p53 around the phosphorylation site of serine 33 (V-L-SP-P-L).
USBio
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50 µg

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333 €

P1001-30F6.100
WB Erklärungen der Abkürzungen ansehen.
Acts as a tumor suppressor in many tumor types. induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Implicated in Notch signaling cross-over. Prevents CDK7 kinase activity when associated to CAK complex in response to DNA damage, thus stopping cell cycle progression. Isoform 2 enhances the transactivation activity of isoform 1 from some but not all TP53-inducible promoters. Isoform 4 suppresses transactivation activity and impairs growth suppression mediated by isoform 1. Isoform 7 inhibits isoform 1-mediated apoptosis. [The UniProt Consortium]

Rabbit IgG SR: human
Immunogen: Synthetic non-phosphopeptide corresponding to human p53 around the phosphorylation site of serine 37 (L-P-SP-Q-A).
USBio
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100 µg

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431 €

P1001-30F6.50
WB Erklärungen der Abkürzungen ansehen.
Acts as a tumor suppressor in many tumor types. induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Implicated in Notch signaling cross-over. Prevents CDK7 kinase activity when associated to CAK complex in response to DNA damage, thus stopping cell cycle progression. Isoform 2 enhances the transactivation activity of isoform 1 from some but not all TP53-inducible promoters. Isoform 4 suppresses transactivation activity and impairs growth suppression mediated by isoform 1. Isoform 7 inhibits isoform 1-mediated apoptosis. [The UniProt Consortium]

Rabbit IgG SR: human
Immunogen: Synthetic non-phosphopeptide corresponding to human p53 around the phosphorylation site of serine 37 (L-P-SP-Q-A).
USBio
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50 µg

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333 €

P1001-30F7.100
WB Erklärungen der Abkürzungen ansehen.
Acts as a tumor suppressor in many tumor types. induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Implicated in Notch signaling cross-over. Prevents CDK7 kinase activity when associated to CAK complex in response to DNA damage, thus stopping cell cycle progression. Isoform 2 enhances the transactivation activity of isoform 1 from some but not all TP53-inducible promoters. Isoform 4 suppresses transactivation activity and impairs growth suppression mediated by isoform 1. Isoform 7 inhibits isoform 1-mediated apoptosis. [The UniProt Consortium]

Rabbit IgG SR: human
Immunogen: Synthetic non-phosphopeptide corresponding to human p53 around the phosphorylation site of serine 46 (M-L-SP-P-D).
USBio
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100 µg

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431 €

P1001-30F7.50
WB Erklärungen der Abkürzungen ansehen.
Acts as a tumor suppressor in many tumor types. induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Implicated in Notch signaling cross-over. Prevents CDK7 kinase activity when associated to CAK complex in response to DNA damage, thus stopping cell cycle progression. Isoform 2 enhances the transactivation activity of isoform 1 from some but not all TP53-inducible promoters. Isoform 4 suppresses transactivation activity and impairs growth suppression mediated by isoform 1. Isoform 7 inhibits isoform 1-mediated apoptosis. [The UniProt Consortium]

Rabbit IgG SR: human
Immunogen: Synthetic non-phosphopeptide corresponding to human p53 around the phosphorylation site of serine 46 (M-L-SP-P-D).
USBio
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50 µg

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333 €

P1001-30G.100
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WB, IHC Erklärungen der Abkürzungen ansehen.
Acts as a tumor suppressor in many tumor types. induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Implicated in Notch signaling cross-over. Prevents CDK7 kinase activity when associated to CAK complex in response to DNA damage, thus stopping cell cycle progression. Isoform 2 enhances the transactivation activity of isoform 1 from some but not all TP53-inducible promoters. Isoform 4 suppresses transactivation activity and impairs growth suppression mediated by isoform 1. Isoform 7 inhibits isoform 1-mediated apoptosis. [The UniProt Consortium]

Mouse IgG SR: human
Immunogen: Recombinant human wild-type p53 protein.
USBio
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100 µg

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544 €

P1001-30Q.100
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WB, IP, IHC, ICC, IF Erklärungen der Abkürzungen ansehen.
Mouse IgG2a SR: human
Immunogen: Recombinant human wild-type p53 protein.
USBio
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100 µg

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445 €

P1001-30R.100
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Rabbit IgG SR: human
Immunogen: Phosphorylated p53 peptide (ser-37) (KLH).
USBio
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100 µg

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542 €

P1001-30S.100
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ELISA, WB Erklärungen der Abkürzungen ansehen.
Rabbit IgG SR: human
Immunogen: Human p53 peptide (15-40aa) (KLH).
USBio
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100 µg

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542 €

P1001-30T.100
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ELISA, WB Erklärungen der Abkürzungen ansehen.
Rabbit IgG SR: human
Immunogen: Human p53 peptide (15-40aa) (KLH).
USBio
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100 µg

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607 €

P1001-30V.100
WB, IP, IHC, ICC Erklärungen der Abkürzungen ansehen.
Protein function: Acts as a tumor suppressor in many tumor types, induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. In cooperation with mitochondrial PPIF is involved in activating oxidative stress-induced necrosis, the function is largely independent of transcription. Induces the transcription of long intergenic non-coding RNA p21 (lincRNA-p21) and lincRNA- Mkln1. LincRNA-p21 participates in TP53-dependent transcriptional repression leading to apoptosis and seem to have to effect on cell-cycle regulation. Implicated in Notch signaling cross-over. Prevents CDK7 kinase activity when associated to CAK complex in response to DNA damage, thus stopping cell cycle progression. Isoform 2 enhances the transactivation activity of isoform 1 from some but not all TP53-inducible promoters. Isoform 4 suppresses transactivation activity and impairs growth suppression mediated by isoform 1. Isoform 7 inhibits isoform 1-mediated apoptosis. [The UniProt Consortium]

Mouse IgG1 SR: human, mouse, rat
Immunogen: Synthetic peptide corresponding to aa surrounding Ser20 of human p53.
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100 µg

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537 €

P1001-30W.100
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Mouse SR: human, mouse
Immunogen: Synthetic peptide corresponding to a portion of p53 phosphorylated at Ser392.
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100 µg

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841 €

P1001-30W.50
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Mouse SR: human, mouse
Immunogen: Synthetic peptide corresponding to a portion of p53 phosphorylated at Ser392.
USBio
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50 µg

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479 €

P1001-30X.100
WB Erklärungen der Abkürzungen ansehen.
Acts as a tumor suppressor in many tumor types. induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. In cooperation with mitochondrial PPIF is involved in activating oxidative stress-induced necrosis. the function is largely independent of transcription. Induces the transcription of long intergenic non-coding RNA p21 (lincRNA-p21) and lincRNA-Mkln1. LincRNA-p21 participates in TP53-dependent transcriptional repression leading to apoptosis and seem to have to effect on cell-cycle regulation. Implicated in Notch signaling cross-over. Prevents CDK7 kinase activity when associated to CAK complex in response to DNA damage, thus stopping cell cycle progression. Isoform 2 enhances the transactivation activity of isoform 1 from some but not all TP53-inducible promoters. Isoform 4 suppresses transactivation activity and impairs growth suppression mediated by isoform 1. Isoform 7 inhibits isoform 1-mediated apoptosis. [The UniProt Consortium]

Rabbit IgG SR: dog, human, mouse, rabbit, rat
Immunogen: Synthetic peptide surrounding aa375 from human p53.
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100 µg

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456 €

P1001-30Y.100
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Purity: Supernatant
Rabbit IgG SR: human
Immunogen: A synthetic phospho-peptide corresponding to residues surrounding Serine 392 of human p53.
USBio
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100 µl

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537 €

P1001-30Z.100
WB, IP, IHC Erklärungen der Abkürzungen ansehen.
Protein function: Acts as a tumor suppressor in many tumor types, induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. In cooperation with mitochondrial PPIF is involved in activating oxidative stress-induced necrosis, the function is largely independent of transcription. Induces the transcription of long intergenic non-coding RNA p21 (lincRNA-p21) and lincRNA- Mkln1. LincRNA-p21 participates in TP53-dependent transcriptional repression leading to apoptosis and seem to have to effect on cell-cycle regulation. Implicated in Notch signaling cross-over. Prevents CDK7 kinase activity when associated to CAK complex in response to DNA damage, thus stopping cell cycle progression. Isoform 2 enhances the transactivation activity of isoform 1 from some but not all TP53-inducible promoters. Isoform 4 suppresses transactivation activity and impairs growth suppression mediated by isoform 1. Isoform 7 inhibits isoform 1-mediated apoptosis. [The UniProt Consortium]

Rabbit IgG SR: human, mouse, rat
Immunogen: Synthetic phosphopeptide surrounding Ser15 of human p53.
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100 µg

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572 €

P1001-32B.500
IHC Erklärungen der Abkürzungen ansehen.
Mouse kappa kappa SR: bovine, human, monkey
USBio
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500 µl

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471 €

P1001-32C.500
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Mouse IgG2a SR: bovine, human, monkey, mouse, rat
USBio
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500 µl

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487 €

P1001-32D.150
ELISA Erklärungen der Abkürzungen ansehen.
Mouse IgG2b SR: human
Immunogen: KLH-conjugated synthetic peptide SHLKSKKGQST corresponding to aa367-377 of human tumor suppressor p53
USBio
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150 µg

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536 €

P1001-32E.150
ELISA Erklärungen der Abkürzungen ansehen.
Mouse IgG1
Immunogen: KLH-conjugated synthetic peptide SHLKS [dimethyl-K]KGQST corresponding to aa367-377 of human tumor suppressor p53
USBio
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150 µg

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536 €

P1001-32F.100
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WB, IHC, ICC Erklärungen der Abkürzungen ansehen.
Acts as a tumor suppressor in many tumor types. induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Implicated in Notch signaling cross-over. Prevents CDK7 kinase activity when associated to CAK complex in response to DNA damage, thus stopping cell cycle progression. Isoform 2 enhances the transactivation activity of isoform 1 from some but not all TP53-inducible promoters. Isoform 4 suppresses transactivation activity and impairs growth suppression mediated by isoform 1. Isoform 7 inhibits isoform 1-mediated apoptosis. [The UniProt Consortium]

Rabbit IgG SR: human, rat
Immunogen: Synthetic peptide directed against the area C-terminal to the transactivation domain of human p53. Cellular Localization: Cytoplasm. Nucleus. Endoplasmic reticulum.
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100 µl

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628 €

P1001-32G2.100
neu

ELISA, WB Erklärungen der Abkürzungen ansehen.
Purity: Purified by immunoaffinit
Rabbit IgG SR: human
Immunogen: Synthesized non-phosphopeptide derived from human p53 around the phosphorylation site of serine 315 (S-S-SP-P-Q)
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100 µg

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372 €

P1001-32G3.100
neu

ELISA, WB, IHC Erklärungen der Abkürzungen ansehen.
Purity: Purified by immunoaffinit
Rabbit IgG SR: human
Immunogen: Synthesized phosphopeptide derived from human p53 around the phosphorylation site of serine 315 (S-S-SP-P-Q)
USBio
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100 µg

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447 €

P1001-32G5.100
neu

ELISA, WB Erklärungen der Abkürzungen ansehen.
Purity: Purified by immunoaffinit
Rabbit IgG SR: human
Immunogen: Synthesized phosphopeptide derived from human p53 around the phosphorylation site of serine 46 (M-L-SP-P-D)
USBio
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100 µg

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447 €

P1001-32G6.100
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WB, IP, ICC, FC Erklärungen der Abkürzungen ansehen.
Acts as a tumor suppressor in many tumor types. induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Implicated in Notch signaling cross-over. Prevents CDK7 kinase activity when associated to CAK complex in response to DNA damage, thus stopping cell cycle progression. Isoform 2 enhances the transactivation activity of isoform 1 from some but not all TP53-inducible promoters. Isoform 4 suppresses transactivation activity and impairs growth suppression mediated by isoform 1. Isoform 7 inhibits isoform 1-mediated apoptosis. [The UniProt Consortium]

Rabbit IgG SR: human
Immunogen: Linear peptide corresponding to p53 (KLH). Epitope: C-Terminus.
USBio
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100 µl

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628 €

P1001-32L2.100
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Mouse IgG1 SR: bovine, chicken, hamster, monkey, mouse, rat
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100 µg

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556 €

P1001-32M.100
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Mouse IgG2a SR: human
USBio
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100 µg

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568 €

P1001-32N.100
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Mouse IgG2a SR: bovine, human, monkey, mouse, rat
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100 µg

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588 €

P1001-32S.100
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Mouse IgG1 SR: bovine, chicken, hamster, human, monkey, mouse, swine, rat
USBio
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100 µg

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588 €

P1001-32U1.1
IHC Erklärungen der Abkürzungen ansehen.
Mouse kappa kappa SR: human
USBio
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1 ml

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491 €

P9198-08C.100
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Rabbit SR: human
Immunogen: synthetic peptide
USBio
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100 µl

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586 €

P9198-08D.100
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WB Erklärungen der Abkürzungen ansehen.
Rabbit SR: human
Immunogen: synthetic peptide
USBio
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100 µl

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586 €

136833.100
neu

ELISA, WB, IP, IHC, FC, RIA Erklärungen der Abkürzungen ansehen.
Mouse IgG1 SR: human
Immunogen: Fusion protein (Human), aa46-53
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100 µg

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482 €

029722.100
WB, IHC Erklärungen der Abkürzungen ansehen.
Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions. Can promote transcription activation through binding to APBB1-KAT5 and inhibits Notch signaling through interaction with Numb. Couples to apoptosis-inducing pathways such as those mediated by G(O) and JIP. Inhibits G(o) alpha ATPase activity (By similarity). Acts as a kinesin I membrane receptor, mediating the axonal transport of beta-secretase and presenilin 1. Involved in copper homeostasis/oxidative stress through copper ion reduction. In vitro, copper-metallated APP induces neuronal death directly or is potentiated through Cu(2+)-mediated low-density lipoprotein oxidation. Can regulate neurite outgrowth through binding to components of the extracellular matrix such as heparin and collagen I and IV. The splice isoforms that contain the BPTI domain possess protease inhibitor activity. Induces a AGER-dependent pathway that involves activation of p38 MAPK, resulting in internalization of amyloid-beta peptide and leading to mitochondrial dysfunction in cultured cortical neurons. Provides Cu(2+) ions for GPC1 which are required for release of nitric oxide (NO) and subsequent degradation of the heparan sulfate chains on GPC1. [The UniProt Consortium]

Rabbit IgG SR: chicken, human, monkey, mouse, rat
Immunogen: Synthetic peptide corresponding to aa737-751 from human amyloid A4 protein precursor (APP) or aa85-99 of the C99 fragment generated by b-secretase cleavage.
USBio
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100 µg

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479 €

031995-APC.200
neu

ELISA, WB Erklärungen der Abkürzungen ansehen.
Rabbit IgG SR: human
Immunogen: APP-Y756 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the Y756 region of human APP .
USBio
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200 µl

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626 €

031995-Biotin.200
neu

ELISA, WB Erklärungen der Abkürzungen ansehen.
Rabbit IgG SR: human
Immunogen: APP-Y756 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the Y756 region of human APP .
USBio
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200 µl

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626 €

031995-FITC.200
neu

ELISA, WB Erklärungen der Abkürzungen ansehen.
Rabbit IgG SR: human
Immunogen: APP-Y756 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the Y756 region of human APP .
USBio
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200 µl

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626 €

031995-HRP.200
neu

ELISA, WB Erklärungen der Abkürzungen ansehen.
Rabbit IgG SR: human
Immunogen: APP-Y756 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the Y756 region of human APP .
USBio
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200 µl

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626 €

031995.200
ELISA, WB Erklärungen der Abkürzungen ansehen.
Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions. Can promote transcription activation through binding to APBB1-KAT5 and inhibits Notch signaling through interaction with Numb. Couples to apoptosis-inducing pathways such as those mediated by G(O) and JIP. Inhibits G(o) alpha ATPase activity (By similarity). Acts as a kinesin I membrane receptor, mediating the axonal transport of beta-secretase and presenilin 1. Involved in copper homeostasis/oxidative stress through copper ion reduction. In vitro, copper-metallated APP induces neuronal death directly or is potentiated through Cu(2+)-mediated low-density lipoprotein oxidation. Can regulate neurite outgrowth through binding to components of the extracellular matrix such as heparin and collagen I and IV. The splice isoforms that contain the BPTI domain possess protease inhibitor activity. Induces a AGER-dependent pathway that involves activation of p38 MAPK, resulting in internalization of amyloid-beta peptide and leading to mitochondrial dysfunction in cultured cortical neurons. Provides Cu(2+) ions for GPC1 which are required for release of nitric oxide (NO) and subsequent degradation of the heparan sulfate chains on GPC1. [The UniProt Consortium]

Rabbit IgG SR: human
Immunogen: APP-Y756 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the Y756 region of human APP .
USBio
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200 µl

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521 €

031996-APC.200
neu

ELISA, WB, IHC, IF Erklärungen der Abkürzungen ansehen.
Rabbit IgG SR: human
Immunogen: APP antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 332-362 amino acids from the Central region of human APP.
USBio
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200 µl

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626 €

031996-Biotin.200
neu

ELISA, WB, IHC, IF Erklärungen der Abkürzungen ansehen.
Rabbit IgG SR: human
Immunogen: APP antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 332-362 amino acids from the Central region of human APP.
USBio
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200 µl

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626 €

031996-FITC.200
neu

ELISA, WB, IHC, IF Erklärungen der Abkürzungen ansehen.
Rabbit IgG SR: human
Immunogen: APP antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 332-362 amino acids from the Central region of human APP.
USBio
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200 µl

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626 €

031996-HRP.200
neu

ELISA, WB, IHC, IF Erklärungen der Abkürzungen ansehen.
Rabbit IgG SR: human
Immunogen: APP antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 332-362 amino acids from the Central region of human APP.
USBio
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200 µl

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626 €

031996.200
ELISA, WB, IHC, IF Erklärungen der Abkürzungen ansehen.
Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions. Can promote transcription activation through binding to APBB1-KAT5 and inhibits Notch signaling through interaction with Numb. Couples to apoptosis-inducing pathways such as those mediated by G(O) and JIP. Inhibits G(o) alpha ATPase activity (By similarity). Acts as a kinesin I membrane receptor, mediating the axonal transport of beta-secretase and presenilin 1. Involved in copper homeostasis/oxidative stress through copper ion reduction. In vitro, copper-metallated APP induces neuronal death directly or is potentiated through Cu(2+)-mediated low-density lipoprotein oxidation. Can regulate neurite outgrowth through binding to components of the extracellular matrix such as heparin and collagen I and IV. The splice isoforms that contain the BPTI domain possess protease inhibitor activity. Induces a AGER-dependent pathway that involves activation of p38 MAPK, resulting in internalization of amyloid-beta peptide and leading to mitochondrial dysfunction in cultured cortical neurons. Provides Cu(2+) ions for GPC1 which are required for release of nitric oxide (NO) and subsequent degradation of the heparan sulfate chains on GPC1. [The UniProt Consortium]

Rabbit IgG SR: human
Immunogen: APP antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 332-362 amino acids from the Central region of human APP.
USBio
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200 µl

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521 €

136753.100
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ELISA, WB, IP, IHC, ICC, IF Erklärungen der Abkürzungen ansehen.
Rabbit SR: human, mouse, rat
Immunogen: Synthetic molecular mimic of soluble oligomers.
USBio
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100 µl

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531 €

137408.100
neu

ELISA Erklärungen der Abkürzungen ansehen.
Rabbit IgG SR: human
Immunogen: Synthetic peptide corresponding to aa1-37 from human beta-amyloid at C-terminal. Species Sequence Homology: mouse, rat, monkey, bovine.
USBio
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100 µl

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555 €

A1372-19A.100
neu

FC Erklärungen der Abkürzungen ansehen.
Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions. Can promote transcription activation through binding to APBB1-KAT5 and inhibits Notch signaling through interaction with Numb. Couples to apoptosis-inducing pathways such as those mediated by G(O) and JIP. Inhibits G(o) alpha ATPase activity (By similarity). Acts as a kinesin I membrane receptor, mediating the axonal transport of beta-secretase and presenilin 1. Involved in copper homeostasis/oxidative stress through copper ion reduction. In vitro, copper-metallated APP induces neuronal death directly or is potentiated through Cu(2)-mediated low-density lipoprotein oxidation. Can regulate neurite outgrowth through binding to components of the extracellular matrix such as heparin and collagen I and IV. The splice isoforms that contain the BPTI domain possess protease inhibitor activity. Induces a AGER-dependent pathway that involves activation of p38 MAPK, resulting in internalization of amyloid-beta peptide and leading to mitochondrial dysfunction in cultured cortical neurons. [The UniProt Consortium]

Mouse IgG1 SR: dog
Immunogen: Purified recombinant Alzheimer precursor A4 (pre A4695) fusion protein
USBio
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100 tests

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491 €

A2275-58X.100
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WB, IP, IHC, ICC, FC Erklärungen der Abkürzungen ansehen.
Recognizes human Amyloid Beta A4 precusor (APP).

Rabbit SR: human, mouse, rat
Immunogen: synthetic peptide
USBio
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100 µl

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586 €

A2275-59D2.50
WB, IHC Erklärungen der Abkürzungen ansehen.
Protein function: Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions. Can promote transcription activation through binding to APBB1-KAT5 and inhibits Notch signaling through interaction with Numb. Couples to apoptosis-inducing pathways such as those mediated by G(O) and JIP. Inhibits G(o) alpha ATPase activity. Acts as a kinesin I membrane receptor, mediating the axonal transport of beta-secretase and presenilin 1. Involved in copper homeostasis/oxidative stress through copper ion reduction. In vitro, copper-metallated APP induces neuronal death directly or is potentiated through Cu(2+)-mediated low-density lipoprotein oxidation. Can regulate neurite outgrowth through binding to components of the extracellular matrix such as heparin and collagen I and IV. The splice isoforms that contain the BPTI domain possess protease inhibitor activity. Induces a AGER- dependent pathway that involves activation of p38 MAPK, resulting in internalization of amyloid-beta peptide and leading to mitochondrial dysfunction in cultured cortical neurons. Provides Cu(2+) ions for GPC1 which are required for release of nitric oxide (NO) and subsequent degradation of the heparan sulfate chains on GPC1. [The UniProt Consortium]

Mouse IgG1 SR: human, mouse, rat
Immunogen: Synthetic peptide corresponding to aa35-42 (MVGGVVIA) of beta-amyloid (1-42).
USBio
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50 µg

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488 €

A2275-59F.100
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WB Erklärungen der Abkürzungen ansehen.
Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions. Can promote transcription activation through binding to APBB1-KAT5 and inhibits Notch signaling through interaction with Numb. Couples to apoptosis-inducing pathways such as those mediated by G(O) and JIP. Inhibits G(o) alpha ATPase activity (By similarity). Acts as a kinesin I membrane receptor, mediating the axonal transport of beta-secretase and presenilin 1. Involved in copper homeostasis/oxidative stress through copper ion reduction. In vitro, copper-metallated APP induces neuronal death directly or is potentiated through Cu(2)-mediated low-density lipoprotein oxidation. Can regulate neurite outgrowth through binding to components of the extracellular matrix such as heparin and collagen I and IV. The splice isoforms that contain the BPTI domain possess protease inhibitor activity. Induces a AGER-dependent pathway that involves activation of p38 MAPK, resulting in internalization of amyloid-beta peptide and leading to mitochondrial dysfunction in cultured cortical neurons. [The UniProt Consortium]

Purity: Supernatant
Rabbit IgG SR: human
Immunogen: A synthetic peptide corresponding to residues in human Beta-amyloid protein 40.
USBio
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100 µl

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537 €

A2275-69D4.100
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ELISA Erklärungen der Abkürzungen ansehen.
Purity: Purified by Protein G aff
Mouse IgG1 kappa SR: human
Immunogen: Synthetic peptide corresponding to the C-terminal sequence (MVGGVVIA) of human beta amyloid peptide 42.
USBio
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100 µl

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667 €

A2275-69S.100
neu

WB, IP Erklärungen der Abkürzungen ansehen.
Purity: Supernatant
Rabbit SR: human
Immunogen: Synthetic peptide corresponding to residues in human Soluble APP.
USBio
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100 µl

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613 €

A2275-69V.100
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ELISA, WB, IHC Erklärungen der Abkürzungen ansehen.
Goat IgG SR: human
Immunogen: Synthetic peptide corresponding to the aa sequence 44-63 of human amyloid precursor protein.
USBio
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100 µl

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566 €

A2275-85H.100
ELISA Erklärungen der Abkürzungen ansehen.
Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions. Can promote transcription activation through binding to APBB1-KAT5 and inhibits Notch signaling through interaction with Numb. Couples to apoptosis-inducing pathways such as those mediated by G(O) and JIP. Inhibits G(o) alpha ATPase activity (By similarity). Acts as a kinesin I membrane receptor, mediating the axonal transport of beta-secretase and presenilin 1. Involved in copper homeostasis/oxidative stress through copper ion reduction. In vitro, copper-metallated APP induces neuronal death directly or is potentiated through Cu(2)-mediated low-density lipoprotein oxidation. Can regulate neurite outgrowth through binding to components of the extracellular matrix such as heparin and collagen I and IV. The splice isoforms that contain the BPTI domain possess protease inhibitor activity. Induces a AGER-dependent pathway that involves activation of p38 MAPK, resulting in internalization of amyloid-beta peptide and leading to mitochondrial dysfunction in cultured cortical neurons. [The UniProt Consortium]

Rabbit IgG SR: human, rabbit
Immunogen: A synthetic peptide (DAEFRHDSGYEVHH) conjugated to BSA corresponding to aa1-14 of mature human beta amyloid.
USBio
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100 µl

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544 €

A2275-85L.200
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ELISA, WB Erklärungen der Abkürzungen ansehen.
Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions. Can promote transcription activation through binding to APBB1-KAT5 and inhibits Notch signaling through interaction with Numb. Couples to apoptosis-inducing pathways such as those mediated by G(O) and JIP. Inhibits G(o) alpha ATPase activity (By similarity). Acts as a kinesin I membrane receptor, mediating the axonal transport of beta-secretase and presenilin 1. Involved in copper homeostasis/oxidative stress through copper ion reduction. In vitro, copper-metallated APP induces neuronal death directly or is potentiated through Cu(2)-mediated low-density lipoprotein oxidation. Can regulate neurite outgrowth through binding to components of the extracellular matrix such as heparin and collagen I and IV. The splice isoforms that contain the BPTI domain possess protease inhibitor activity. Induces a AGER-dependent pathway that involves activation of p38 MAPK, resulting in internalization of amyloid-beta peptide and leading to mitochondrial dysfunction in cultured cortical neurons. [The UniProt Consortium]

Rabbit IgG SR: human
Immunogen: Synthetic phosphopeptide corresponding to amino acid residues surrounding S730 of human APP (KLH).
USBio
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200 µl

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521 €

A2275-85P.200
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ELISA, WB, IHC Erklärungen der Abkürzungen ansehen.
Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions. Can promote transcription activation through binding to APBB1-KAT5 and inhibits Notch signaling through interaction with Numb. Couples to apoptosis-inducing pathways such as those mediated by G(O) and JIP. Inhibits G(o) alpha ATPase activity (By similarity). Acts as a kinesin I membrane receptor, mediating the axonal transport of beta-secretase and presenilin 1. Involved in copper homeostasis/oxidative stress through copper ion reduction. In vitro, copper-metallated APP induces neuronal death directly or is potentiated through Cu(2)-mediated low-density lipoprotein oxidation. Can regulate neurite outgrowth through binding to components of the extracellular matrix such as heparin and collagen I and IV. The splice isoforms that contain the BPTI domain possess protease inhibitor activity. Induces a AGER-dependent pathway that involves activation of p38 MAPK, resulting in internalization of amyloid-beta peptide and leading to mitochondrial dysfunction in cultured cortical neurons. [The UniProt Consortium]

Rabbit IgG SR: human, mouse
Immunogen: Synthetic peptide selected from the N-terminal region of human APP (KLH).
USBio
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200 µl

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521 €

A2275-85Q.200
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ELISA, WB Erklärungen der Abkürzungen ansehen.
Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions. Can promote transcription activation through binding to APBB1-KAT5 and inhibits Notch signaling through interaction with Numb. Couples to apoptosis-inducing pathways such as those mediated by G(O) and JIP. Inhibits G(o) alpha ATPase activity (By similarity). Acts as a kinesin I membrane receptor, mediating the axonal transport of beta-secretase and presenilin 1. Involved in copper homeostasis/oxidative stress through copper ion reduction. In vitro, copper-metallated APP induces neuronal death directly or is potentiated through Cu(2)-mediated low-density lipoprotein oxidation. Can regulate neurite outgrowth through binding to components of the extracellular matrix such as heparin and collagen I and IV. The splice isoforms that contain the BPTI domain possess protease inhibitor activity. Induces a AGER-dependent pathway that involves activation of p38 MAPK, resulting in internalization of amyloid-beta peptide and leading to mitochondrial dysfunction in cultured cortical neurons. [The UniProt Consortium]

Rabbit IgG SR: human
Immunogen: Synthetic peptide selected from the C-terminal region of human APP (KLH).
USBio
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200 µl

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521 €

A2275-86C.500
IHC Erklärungen der Abkürzungen ansehen.
Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions. Can promote transcription activation through binding to APBB1-KAT5 and inhibits Notch signaling through interaction with Numb. Couples to apoptosis-inducing pathways such as those mediated by G(O) and JIP. Inhibits G(o) alpha ATPase activity (By similarity). Acts as a kinesin I membrane receptor, mediating the axonal transport of beta-secretase and presenilin 1. Involved in copper homeostasis/oxidative stress through copper ion reduction. In vitro, copper-metallated APP induces neuronal death directly or is potentiated through Cu(2)-mediated low-density lipoprotein oxidation. Can regulate neurite outgrowth through binding to components of the extracellular matrix such as heparin and collagen I and IV. The splice isoforms that contain the BPTI domain possess protease inhibitor activity. Induces a AGER-dependent pathway that involves activation of p38 MAPK, resulting in internalization of amyloid-beta peptide and leading to mitochondrial dysfunction in cultured cortical neurons. Provides Cu(2) ions for GPC1 which are required for release of nitric oxide (NO) and subsequent degradation of the heparan sulfate chains on GPC1. [The UniProt Consortium]

Rabbit IgG SR: human, mouse, rat
Immunogen: Synthetic peptide corresponding to N-terminal of human APP.
USBio
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500 µl

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568 €

A2275-86D.100
WB Erklärungen der Abkürzungen ansehen.
Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions. Can promote transcription activation through binding to APBB1-KAT5 and inhibits Notch signaling through interaction with Numb. Couples to apoptosis-inducing pathways such as those mediated by G(O) and JIP. Inhibits G(o) alpha ATPase activity (By similarity). Acts as a kinesin I membrane receptor, mediating the axonal transport of beta-secretase and presenilin 1. Involved in copper homeostasis/oxidative stress through copper ion reduction. In vitro, copper-metallated APP induces neuronal death directly or is potentiated through Cu(2)-mediated low-density lipoprotein oxidation. Can regulate neurite outgrowth through binding to components of the extracellular matrix such as heparin and collagen I and IV. The splice isoforms that contain the BPTI domain possess protease inhibitor activity. Induces a AGER-dependent pathway that involves activation of p38 MAPK, resulting in internalization of amyloid-beta peptide and leading to mitochondrial dysfunction in cultured cortical neurons. Provides Cu(2) ions for GPC1 which are required for release of nitric oxide (NO) and subsequent degradation of the heparan sulfate chains on GPC1. [The UniProt Consortium]

Rabbit IgG SR: human, mouse, rat
Immunogen: Synthetic peptide corresponding to aa residues 653-662 of human APP.
USBio
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100 µg

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726 €

A2275-86E.100
WB Erklärungen der Abkürzungen ansehen.
Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions. Can promote transcription activation through binding to APBB1-KAT5 and inhibits Notch signaling through interaction with Numb. Couples to apoptosis-inducing pathways such as those mediated by G(O) and JIP. Inhibits G(o) alpha ATPase activity (By similarity). Acts as a kinesin I membrane receptor, mediating the axonal transport of beta-secretase and presenilin 1. Involved in copper homeostasis/oxidative stress through copper ion reduction. In vitro, copper-metallated APP induces neuronal death directly or is potentiated through Cu(2)-mediated low-density lipoprotein oxidation. Can regulate neurite outgrowth through binding to components of the extracellular matrix such as heparin and collagen I and IV. The splice isoforms that contain the BPTI domain possess protease inhibitor activity. Induces a AGER-dependent pathway that involves activation of p38 MAPK, resulting in internalization of amyloid-beta peptide and leading to mitochondrial dysfunction in cultured cortical neurons. Provides Cu(2) ions for GPC1 which are required for release of nitric oxide (NO) and subsequent degradation of the heparan sulfate chains on GPC1. [The UniProt Consortium]

Rabbit IgG SR: human, mouse, rat
Immunogen: Synthetic peptide corresponding to aa residues 737-751 of human APP.
USBio
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100 µg

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726 €

A2275-86F.500 b-​Amyloid Protein 40, Recombinant, Human (ABPP, APPI, APP, Alzheimer Disease Amyloid Protein, Cerebral Vascular Amyloid Peptide, CVAP, PreA4, Protease Nexin-​II, PN-​II, APP, A4, AD1) USBio
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500 µg

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448 €

A2275-86G.500 b-​Amyloid Protein 42, Recombinant, Human (ABPP, APPI, APP, Alzheimer Disease Amyloid Protein, Cerebral Vascular Amyloid Peptide, CVAP, PreA4, Protease Nexin-​II, PN-​II, APP, A4, AD1) USBio
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500 µg

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448 €

A2275-86S.100
IHC Erklärungen der Abkürzungen ansehen.
Protein function: Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions. Can promote transcription activation through binding to APBB1-KAT5 and inhibits Notch signaling through interaction with Numb. Couples to apoptosis-inducing pathways such as those mediated by G(O) and JIP. Inhibits G(o) alpha ATPase activity. Acts as a kinesin I membrane receptor, mediating the axonal transport of beta-secretase and presenilin 1. Involved in copper homeostasis/oxidative stress through copper ion reduction. In vitro, copper-metallated APP induces neuronal death directly or is potentiated through Cu(2+)-mediated low-density lipoprotein oxidation. Can regulate neurite outgrowth through binding to components of the extracellular matrix such as heparin and collagen I and IV. The splice isoforms that contain the BPTI domain possess protease inhibitor activity. Induces a AGER- dependent pathway that involves activation of p38 MAPK, resulting in internalization of amyloid-beta peptide and leading to mitochondrial dysfunction in cultured cortical neurons. Provides Cu(2+) ions for GPC1 which are required for release of nitric oxide (NO) and subsequent degradation of the heparan sulfate chains on GPC1. [The UniProt Consortium]

Mouse IgG1 SR: human
Immunogen: Synthetic peptide corresponding to aa1-17 from Amyloid Beta protein.
USBio
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100 µg

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520 €

A2275-86T.100
IHC Erklärungen der Abkürzungen ansehen.
Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions. Can promote transcription activation through binding to APBB1-KAT5 and inhibits Notch signaling through interaction with Numb. Couples to apoptosis-inducing pathways such as those mediated by G(O) and JIP. Inhibits G(o) alpha ATPase activity (By similarity). Acts as a kinesin I membrane receptor, mediating the axonal transport of beta-secretase and presenilin 1. Involved in copper homeostasis/oxidative stress through copper ion reduction. In vitro, copper-metallated APP induces neuronal death directly or is potentiated through Cu(2+)-mediated low-density lipoprotein oxidation. Can regulate neurite outgrowth through binding to components of the extracellular matrix such as heparin and collagen I and IV. The splice isoforms that contain the BPTI domain possess protease inhibitor activity. Induces a AGER-dependent pathway that involves activation of p38 MAPK, resulting in internalization of amyloid-beta peptide and leading to mitochondrial dysfunction in cultured cortical neurons. Provides Cu(2+) ions for GPC1 which are required for release of nitric oxide (NO) and subsequent degradation of the heparan sulfate chains on GPC1. [The UniProt Consortium]

Mouse IgG SR: human
Immunogen: Synthetic peptide corresponding to aa1-17 from Amyloid Beta protein.
USBio
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100 µg

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520 €

A2275-87G.100
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WB, IHC Erklärungen der Abkürzungen ansehen.
Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions. Can promote transcription activation through binding to APBB1-KAT5 and inhibits Notch signaling through interaction with Numb. Couples to apoptosis-inducing pathways such as those mediated by G(O) and JIP. Inhibits G(o) alpha ATPase activity (By similarity). Acts as a kinesin I membrane receptor, mediating the axonal transport of beta-secretase and presenilin 1. Involved in copper homeostasis/oxidative stress through copper ion reduction. In vitro, copper-metallated APP induces neuronal death directly or is potentiated through Cu(2)-mediated low-density lipoprotein oxidation. Can regulate neurite outgrowth through binding to components of the extracellular matrix such as heparin and collagen I and IV. The splice isoforms that contain the BPTI domain possess protease inhibitor activity. Induces a AGER-dependent pathway that involves activation of p38 MAPK, resulting in internalization of amyloid-beta peptide and leading to mitochondrial dysfunction in cultured cortical neurons. [The UniProt Consortium]

Rabbit SR: human, mouse, rat
Immunogen: Linear peptide corresponding to human Amyloid beta A4 protein (KLH).
USBio
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100 µg

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562 €

A2275-87Q.100
ELISA Erklärungen der Abkürzungen ansehen.
Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions. Can promote transcription activation through binding to APBB1-KAT5 and inhibits Notch signaling through interaction with Numb. Couples to apoptosis-inducing pathways such as those mediated by G(O) and JIP. Inhibits G(o) alpha ATPase activity (By similarity). Acts as a kinesin I membrane receptor, mediating the axonal transport of beta-secretase and presenilin 1. Involved in copper homeostasis/oxidative stress through copper ion reduction. In vitro, copper-metallated APP induces neuronal death directly or is potentiated through Cu(2)-mediated low-density lipoprotein oxidation. Can regulate neurite outgrowth through binding to components of the extracellular matrix such as heparin and collagen I and IV. The splice isoforms that contain the BPTI domain possess protease inhibitor activity. Induces a AGER-dependent pathway that involves activation of p38 MAPK, resulting in internalization of amyloid-beta peptide and leading to mitochondrial dysfunction in cultured cortical neurons. [The UniProt Consortium]

Rabbit IgG SR: human
Immunogen: Synthetic peptide corresponding to aa653-665 (RPGSGLTNIKTEE) of human amyloid beta A4 protein precursor, isoform a, Genbank accession no. NP_000475.1.
USBio
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100 µl

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373 €

A2275-87R.100
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ELISA, WB, IHC, ICC Erklärungen der Abkürzungen ansehen.
Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions. Can promote transcription activation through binding to APBB1-KAT5 and inhibits Notch signaling through interaction with Numb. Couples to apoptosis-inducing pathways such as those mediated by G(O) and JIP. Inhibits G(o) alpha ATPase activity (By similarity). Acts as a kinesin I membrane receptor, mediating the axonal transport of beta-secretase and presenilin 1. Involved in copper homeostasis/oxidative stress through copper ion reduction. In vitro, copper-metallated APP induces neuronal death directly or is potentiated through Cu(2)-mediated low-density lipoprotein oxidation. Can regulate neurite outgrowth through binding to components of the extracellular matrix such as heparin and collagen I and IV. The splice isoforms that contain the BPTI domain possess protease inhibitor activity. Induces a AGER-dependent pathway that involves activation of p38 MAPK, resulting in internalization of amyloid-beta peptide and leading to mitochondrial dysfunction in cultured cortical neurons. [The UniProt Consortium]

Mouse IgG1 kappa SR: human, mouse
Immunogen: Recombinant protein corresponding to human Amyloid beta A4 protein.
USBio
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100 µg

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562 €

A2275-87S.50
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WB Erklärungen der Abkürzungen ansehen.
Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions. Can promote transcription activation through binding to APBB1-KAT5 and inhibits Notch signaling through interaction with Numb. Couples to apoptosis-inducing pathways such as those mediated by G(O) and JIP. Inhibits G(o) alpha ATPase activity (By similarity). Acts as a kinesin I membrane receptor, mediating the axonal transport of beta-secretase and presenilin 1. Involved in copper homeostasis/oxidative stress through copper ion reduction. In vitro, copper-metallated APP induces neuronal death directly or is potentiated through Cu(2)-mediated low-density lipoprotein oxidation. Can regulate neurite outgrowth through binding to components of the extracellular matrix such as heparin and collagen I and IV. The splice isoforms that contain the BPTI domain possess protease inhibitor activity. Induces a AGER-dependent pathway that involves activation of p38 MAPK, resulting in internalization of amyloid-beta peptide and leading to mitochondrial dysfunction in cultured cortical neurons. [The UniProt Consortium]

Rabbit IgG SR: human, mouse, rat
Immunogen: Synthetic peptide corresponding to aa653-662 of human amyloid A4 protein precursor (APP) or aa1-10 of the 4K Ab peptide generated by b- and g-secretases.
USBio
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50 µg

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570 €

A2275-87T.50
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WB Erklärungen der Abkürzungen ansehen.
Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions. Can promote transcription activation through binding to APBB1-KAT5 and inhibits Notch signaling through interaction with Numb. Couples to apoptosis-inducing pathways such as those mediated by G(O) and JIP. Inhibits G(o) alpha ATPase activity (By similarity). Acts as a kinesin I membrane receptor, mediating the axonal transport of beta-secretase and presenilin 1. Involved in copper homeostasis/oxidative stress through copper ion reduction. In vitro, copper-metallated APP induces neuronal death directly or is potentiated through Cu(2)-mediated low-density lipoprotein oxidation. Can regulate neurite outgrowth through binding to components of the extracellular matrix such as heparin and collagen I and IV. The splice isoforms that contain the BPTI domain possess protease inhibitor activity. Induces a AGER-dependent pathway that involves activation of p38 MAPK, resulting in internalization of amyloid-beta peptide and leading to mitochondrial dysfunction in cultured cortical neurons. [The UniProt Consortium]

Rabbit IgG SR: human, mouse, rat
Immunogen: Synthetic peptide corresponding to aa737-751 of human amyloid A4 protein precursor (APP) or residues 85-99 of the C99 fragment generated by B-secretase cleavage.
USBio
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50 µg

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570 €

A2275-87U.50
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WB Erklärungen der Abkürzungen ansehen.
Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions. Can promote transcription activation through binding to APBB1-KAT5 and inhibits Notch signaling through interaction with Numb. Couples to apoptosis-inducing pathways such as those mediated by G(O) and JIP. Inhibits G(o) alpha ATPase activity (By similarity). Acts as a kinesin I membrane receptor, mediating the axonal transport of beta-secretase and presenilin 1. Involved in copper homeostasis/oxidative stress through copper ion reduction. In vitro, copper-metallated APP induces neuronal death directly or is potentiated through Cu(2)-mediated low-density lipoprotein oxidation. Can regulate neurite outgrowth through binding to components of the extracellular matrix such as heparin and collagen I and IV. The splice isoforms that contain the BPTI domain possess protease inhibitor activity. Induces a AGER-dependent pathway that involves activation of p38 MAPK, resulting in internalization of amyloid-beta peptide and leading to mitochondrial dysfunction in cultured cortical neurons. [The UniProt Consortium]

Rabbit IgG SR: human, mouse, rat
Immunogen: Synthetic phosphopeptide corresponding to human APP around the phosphorylation site of threonine 668 (A-V-TP-P-E).
USBio
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50 µg

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560 €

A2275-87U1.50
neu

WB, IHC Erklärungen der Abkürzungen ansehen.
Purity: Purified by immunoaffinit
Rabbit SR: human
Immunogen: Synthetic peptide corresponding to human APP.
USBio
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50 µg

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601 €

C2605-80.100
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WB Erklärungen der Abkürzungen ansehen.
Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions. Can promote transcription activation through binding to APBB1-KAT5 and inhibits Notch signaling through interaction with Numb. Couples to apoptosis-inducing pathways such as those mediated by G(O) and JIP. Inhibits G(o) alpha ATPase activity (By similarity). Acts as a kinesin I membrane receptor, mediating the axonal transport of beta-secretase and presenilin 1. Involved in copper homeostasis/oxidative stress through copper ion reduction. In vitro, copper-metallated APP induces neuronal death directly or is potentiated through Cu(2)-mediated low-density lipoprotein oxidation. Can regulate neurite outgrowth through binding to components of the extracellular matrix such as heparin and collagen I and IV. The splice isoforms that contain the BPTI domain possess protease inhibitor activity. Induces a AGER-dependent pathway that involves activation of p38 MAPK, resulting in internalization of amyloid-beta peptide and leading to mitochondrial dysfunction in cultured cortical neurons. [The UniProt Consortium]

Mouse IgM kappa SR: rat
Immunogen: Untreated NT2/D1 cells corresponding to rat cell surface marker.
USBio
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100 µg

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562 €

H1850-10C.250
neu

ELISA, IHC Erklärungen der Abkürzungen ansehen.
Purity: Purified by Protein G aff
Mouse IgG1 SR: human
Immunogen: Purified human hemoglobin
USBio
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250 µg

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601 €

H1850-40.50
neu

ELISA, WB, IHC Erklärungen der Abkürzungen ansehen.
Purity: Purified by Protein A aff
Mouse IgG1 kappa SR: human
Immunogen: Recombinant corresponding to aa38-148 from human HBB with GST tag. MW of the GST tag alone is 26kD.
USBio
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50 µg

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717 €

P6000-01A.1
Gel Erklärungen der Abkürzungen ansehen.
Thyroid hormone-binding protein. Probably transports thyroxine from the bloodstream to the brain. [The UniProt Consortium]

Sheep IgG SR: human
Immunogen: Human prealbumin.
USBio
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1 ml

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634 €

P6000-05A.100
ELISA Erklärungen der Abkürzungen ansehen.
Thyroid hormone-binding protein. Probably transports thyroxine from the bloodstream to the brain. [The UniProt Consortium]

Goat IgG
Immunogen: Synthetic peptide corresponding to C-YKVEIDTKSYWK, from the internal region of the protein sequence according to NP_000362.1.
USBio
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100 µg

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668 €

P6000-11A.200
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ELISA, WB Erklärungen der Abkürzungen ansehen.
Thyroid hormone-binding protein. Probably transports thyroxine from the bloodstream to the brain. [The UniProt Consortium]

Rabbit IgG SR: human
Immunogen: Synthetic peptide selected from the C-terminal region of human PALB (KLH).
USBio
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200 µl

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521 €

P6000-11B.200
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ELISA, WB, IHC Erklärungen der Abkürzungen ansehen.
Thyroid hormone-binding protein. Probably transports thyroxine from the bloodstream to the brain. [The UniProt Consortium]

Rabbit IgG SR: human
Immunogen: Synthetic peptide selected from the Center region of human PALB (KLH).
USBio
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200 µl

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521 €

P6000-13.50
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ELISA, WB Erklärungen der Abkürzungen ansehen.
Thyroid hormone-binding protein. Probably transports thyroxine from the bloodstream to the brain. [The UniProt Consortium]

Mouse IgG1 kappa SR: human, mouse
Immunogen: Recombinant correspnding to human TTR aa21-147 expressed in E. coli.
USBio
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50 µl

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375 €

P6000.1
ELISA Erklärungen der Abkürzungen ansehen.
Thyroid hormone-binding protein. Probably transports thyroxine from the bloodstream to the brain. [The UniProt Consortium]

Goat IgG SR: human
Immunogen: Purified Human Pre-Albumin
USBio
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1 ml

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316 €

045590.100
neu

WB, IP, ICC Erklärungen der Abkürzungen ansehen.
Purity: Supernatant
Rabbit SR: human, rat
Immunogen: Synthetic peptide corresponding to residues in human INSR.
USBio
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100 µl

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537 €

I7661-22D1.50
IHC Erklärungen der Abkürzungen ansehen.
Receptor tyrosine kinase which mediates the pleiotropic actions of insulin. Binding of insulin leads to phosphorylation of several intracellular substrates, including, insulin receptor substrates (IRS1, 2, 3, 4), SHC, GAB1, CBL and other signaling intermediates. Each of these phosphorylated proteins serve as docking proteins for other signaling proteins that contain Src-homology-2 domains (SH2 domain) that specifically recognize different phosphotyrosines residues, including the p85 regulatory subunit of PI3K and SHP2. Phosphorylation of IRSs proteins lead to the activation of two main signaling pathways: the PI3K-AKT/PKB pathway, which is responsible for most of the metabolic actions of insulin, and the Ras-MAPK pathway, which regulates expression of some genes and cooperates with the PI3K pathway to control cell growth and differentiation. Binding of the SH2 domains of PI3K to phosphotyrosines on IRS1 leads to the activation of PI3K and the generation of phosphatidylinositol-(3, 4, 5)-triphosphate (PIP3), a lipid second messenger, which activates several PIP3-dependent serine/threonine kinases, such as PDPK1 and subsequently AKT/PKB. The net effect of this pathway is to produce a translocation of the glucose transporter SLC2A4/GLUT4 from cytoplasmic vesicles to the cell membrane to facilitate glucose transport. Moreover, upon insulin stimulation, activated AKT/PKB is responsible for: anti-apoptotic effect of insulin by inducing phosphorylation of BAD. regulates the expressi

Rabbit SR: human
Immunogen: Synthetic peptide, KLH-conjugated. Epitope: internal domain of human
USBio
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50 µg

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642 €

I7661-22D2.50
ELISA, IHC Erklärungen der Abkürzungen ansehen.
Receptor tyrosine kinase which mediates the pleiotropic actions of insulin. Binding of insulin leads to phosphorylation of several intracellular substrates, including, insulin receptor substrates (IRS1, 2, 3, 4), SHC, GAB1, CBL and other signaling intermediates. Each of these phosphorylated proteins serve as docking proteins for other signaling proteins that contain Src-homology-2 domains (SH2 domain) that specifically recognize different phosphotyrosines residues, including the p85 regulatory subunit of PI3K and SHP2. Phosphorylation of IRSs proteins lead to the activation of two main signaling pathways: the PI3K-AKT/PKB pathway, which is responsible for most of the metabolic actions of insulin, and the Ras-MAPK pathway, which regulates expression of some genes and cooperates with the PI3K pathway to control cell growth and differentiation. Binding of the SH2 domains of PI3K to phosphotyrosines on IRS1 leads to the activation of PI3K and the generation of phosphatidylinositol-(3, 4, 5)-triphosphate (PIP3), a lipid second messenger, which activates several PIP3-dependent serine/threonine kinases, such as PDPK1 and subsequently AKT/PKB. The net effect of this pathway is to produce a translocation of the glucose transporter SLC2A4/GLUT4 from cytoplasmic vesicles to the cell membrane to facilitate glucose transport. Moreover, upon insulin stimulation, activated AKT/PKB is responsible for: anti-apoptotic effect of insulin by inducing phosphorylation of BAD. regulates the expressi

Rabbit SR: human
Immunogen: Synthetic peptide, KLH-conjugated. Epitope: internal domain of human
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50 µg

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642 €

I7661-22G.5
Receptor tyrosine kinase which mediates the pleiotropic actions of insulin. Binding of insulin leads to phosphorylation of several intracellular substrates, including, insulin receptor substrates (IRS1, 2, 3, 4), SHC, GAB1, CBL and other signaling intermediates. Each of these phosphorylated proteins serve as docking proteins for other signaling proteins that contain Src-homology-2 domains (SH2 domain) that specifically recognize different phosphotyrosines residues, including the p85 regulatory subunit of PI3K and SHP2. Phosphorylation of IRSs proteins lead to the activation of two main signaling pathways: the PI3K-AKT/PKB pathway, which is responsible for most of the metabolic actions of insulin, and the Ras-MAPK pathway, which regulates expression of some genes and cooperates with the PI3K pathway to control cell growth and differentiation. Binding of the SH2 domains of PI3K to phosphotyrosines on IRS1 leads to the activation of PI3K and the generation of phosphatidylinositol-(3, 4, 5)-triphosphate (PIP3), a lipid second messenger, which activates several PIP3-dependent serine/threonine kinases, such as PDPK1 and subsequently AKT/PKB. The net effect of this pathway is to produce a translocation of the glucose transporter SLC2A4/GLUT4 from cytoplasmic vesicles to the cell membrane to facilitate glucose transport. Moreover, upon insulin stimulation, activated AKT/PKB is responsible for: anti-apoptotic effect of insulin by inducing phosphorylation of BAD. regulates the expressi

MW: 37 kD
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5 µg

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589 €

I7661-23N.50
IHC Erklärungen der Abkürzungen ansehen.
Receptor tyrosine kinase which mediates the pleiotropic actions of insulin. Binding of insulin leads to phosphorylation of several intracellular substrates, including, insulin receptor substrates (IRS1, 2, 3, 4), SHC, GAB1, CBL and other signaling intermediates. Each of these phosphorylated proteins serve as docking proteins for other signaling proteins that contain Src-homology-2 domains (SH2 domain) that specifically recognize different phosphotyrosines residues, including the p85 regulatory subunit of PI3K and SHP2. Phosphorylation of IRSs proteins lead to the activation of two main signaling pathways: the PI3K-AKT/PKB pathway, which is responsible for most of the metabolic actions of insulin, and the Ras-MAPK pathway, which regulates expression of some genes and cooperates with the PI3K pathway to control cell growth and differentiation. Binding of the SH2 domains of PI3K to phosphotyrosines on IRS1 leads to the activation of PI3K and the generation of phosphatidylinositol-(3, 4, 5)-triphosphate (PIP3), a lipid second messenger, which activates several PIP3-dependent serine/threonine kinases, such as PDPK1 and subsequently AKT/PKB. The net effect of this pathway is to produce a translocation of the glucose transporter SLC2A4/GLUT4 from cytoplasmic vesicles to the cell membrane to facilitate glucose transport. Moreover, upon insulin stimulation, activated AKT/PKB is responsible for: anti-apoptotic effect of insulin by inducing phosphorylation of BAD. regulates the expressi

Rabbit IgG SR: human
Immunogen: Synthetic peptide corresponding to the internal domain of human INSR.
USBio
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50 µg

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715 €

I7661-23P.100
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WB, IP, ICC Erklärungen der Abkürzungen ansehen.
Receptor tyrosine kinase which mediates the pleiotropic actions of insulin. Binding of insulin leads to phosphorylation of several intracellular substrates, including, insulin receptor substrates (IRS1, 2, 3, 4), SHC, GAB1, CBL and other signaling intermediates. Each of these phosphorylated proteins serve as docking proteins for other signaling proteins that contain Src-homology-2 domains (SH2 domain) that specifically recognize different phosphotyrosines residues, including the p85 regulatory subunit of PI3K and SHP2. Phosphorylation of IRSs proteins lead to the activation of two main signaling pathways: the PI3K-AKT/PKB pathway, which is responsible for most of the metabolic actions of insulin, and the Ras-MAPK pathway, which regulates expression of some genes and cooperates with the PI3K pathway to control cell growth and differentiation. Binding of the SH2 domains of PI3K to phosphotyrosines on IRS1 leads to the activation of PI3K and the generation of phosphatidylinositol-(3, 4, 5)-triphosphate (PIP3), a lipid second messenger, which activates several PIP3-dependent serine/threonine kinases, such as PDPK1 and subsequently AKT/PKB. The net effect of this pathway is to produce a translocation of the glucose transporter SLC2A4/GLUT4 from cytoplasmic vesicles to the cell membrane to facilitate glucose transport. Moreover, upon insulin stimulation, activated AKT/PKB is responsible for: anti-apoptotic effect of insulin by inducing phosphorylation of BAD. regulates the expressi

Rabbit IgG SR: human
Immunogen: A phospho synthetic peptide corresponding to residues surrounding Tyrosine 1185 of human INSR
USBio
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100 µl

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586 €

I7661-23S.200
ELISA, Gel Erklärungen der Abkürzungen ansehen.
Receptor tyrosine kinase which mediates the pleiotropic actions of insulin. Binding of insulin leads to phosphorylation of several intracellular substrates, including, insulin receptor substrates (IRS1, 2, 3, 4), SHC, GAB1, CBL and other signaling intermediates. Each of these phosphorylated proteins serve as docking proteins for other signaling proteins that contain Src-homology-2 domains (SH2 domain) that specifically recognize different phosphotyrosines residues, including the p85 regulatory subunit of PI3K and SHP2. Phosphorylation of IRSs proteins lead to the activation of two main signaling pathways: the PI3K-AKT/PKB pathway, which is responsible for most of the metabolic actions of insulin, and the Ras-MAPK pathway, which regulates expression of some genes and cooperates with the PI3K pathway to control cell growth and differentiation. Binding of the SH2 domains of PI3K to phosphotyrosines on IRS1 leads to the activation of PI3K and the generation of phosphatidylinositol-(3, 4, 5)-triphosphate (PIP3), a lipid second messenger, which activates several PIP3-dependent serine/threonine kinases, such as PDPK1 and subsequently AKT/PKB. The net effect of this pathway is to produce a translocation of the glucose transporter SLC2A4/GLUT4 from cytoplasmic vesicles to the cell membrane to facilitate glucose transport. Moreover, upon insulin stimulation, activated AKT/PKB is responsible for: anti-apoptotic effect of insulin by inducing phosphorylation of BAD. regulates the expressi

Rabbit IgG SR: human
Immunogen: Synthetic phosphopeptide corresponding to amino acid residues surrounding Y1185 of human INSR (KLH).
USBio
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200 µl

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521 €

I7661-23T.200
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ELISA, WB, IHC Erklärungen der Abkürzungen ansehen.
Receptor tyrosine kinase which mediates the pleiotropic actions of insulin. Binding of insulin leads to phosphorylation of several intracellular substrates, including, insulin receptor substrates (IRS1, 2, 3, 4), SHC, GAB1, CBL and other signaling intermediates. Each of these phosphorylated proteins serve as docking proteins for other signaling proteins that contain Src-homology-2 domains (SH2 domain) that specifically recognize different phosphotyrosines residues, including the p85 regulatory subunit of PI3K and SHP2. Phosphorylation of IRSs proteins lead to the activation of two main signaling pathways: the PI3K-AKT/PKB pathway, which is responsible for most of the metabolic actions of insulin, and the Ras-MAPK pathway, which regulates expression of some genes and cooperates with the PI3K pathway to control cell growth and differentiation. Binding of the SH2 domains of PI3K to phosphotyrosines on IRS1 leads to the activation of PI3K and the generation of phosphatidylinositol-(3, 4, 5)-triphosphate (PIP3), a lipid second messenger, which activates several PIP3-dependent serine/threonine kinases, such as PDPK1 and subsequently AKT/PKB. The net effect of this pathway is to produce a translocation of the glucose transporter SLC2A4/GLUT4 from cytoplasmic vesicles to the cell membrane to facilitate glucose transport. Moreover, upon insulin stimulation, activated AKT/PKB is responsible for: anti-apoptotic effect of insulin by inducing phosphorylation of BAD. regulates the expressi

Rabbit IgG SR: human
Immunogen: Synthetic peptide selected from the N-terminal region of human INSR (KLH).
USBio
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200 µl

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521 €

I7661-23Y.50
IHC Erklärungen der Abkürzungen ansehen.
Receptor tyrosine kinase which mediates the pleiotropic actions of insulin. Binding of insulin leads to phosphorylation of several intracellular substrates, including, insulin receptor substrates (IRS1, 2, 3, 4), SHC, GAB1, CBL and other signaling intermediates. Each of these phosphorylated proteins serve as docking proteins for other signaling proteins that contain Src-homology-2 domains (SH2 domain) that specifically recognize different phosphotyrosines residues, including the p85 regulatory subunit of PI3K and SHP2. Phosphorylation of IRSs proteins lead to the activation of two main signaling pathways: the PI3K-AKT/PKB pathway, which is responsible for most of the metabolic actions of insulin, and the Ras-MAPK pathway, which regulates expression of some genes and cooperates with the PI3K pathway to control cell growth and differentiation. Binding of the SH2 domains of PI3K to phosphotyrosines on IRS1 leads to the activation of PI3K and the generation of phosphatidylinositol-(3, 4, 5)-triphosphate (PIP3), a lipid second messenger, which activates several PIP3-dependent serine/threonine kinases, such as PDPK1 and subsequently AKT/PKB. The net effect of this pathway is to produce a translocation of the glucose transporter SLC2A4/GLUT4 from cytoplasmic vesicles to the cell membrane to facilitate glucose transport. Moreover, upon insulin stimulation, activated AKT/PKB is responsible for: anti-apoptotic effect of insulin by inducing phosphorylation of BAD. regulates the expressi

Rabbit IgG SR: human
Immunogen: Synthetic peptide corresponding to the internal domain of human INSR.
USBio
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50 µg

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715 €

I7661-25D.100
Neutr. Erklärungen der Abkürzungen ansehen.
Mouse IgG1 SR: bovine, human, swine, rabbit, sheep
USBio
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100 µg

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601 €

I7661-25F.100
related products

WB, IHC Erklärungen der Abkürzungen ansehen.
Receptor tyrosine kinase which mediates the pleiotropic actions of insulin. Binding of insulin leads to phosphorylation of several intracellular substrates, including, insulin receptor substrates (IRS1, 2, 3, 4), SHC, GAB1, CBL and other signaling intermediates. Each of these phosphorylated proteins serve as docking proteins for other signaling proteins that contain Src-homology-2 domains (SH2 domain) that specifically recognize different phosphotyrosines residues, including the p85 regulatory subunit of PI3K and SHP2. Phosphorylation of IRSs proteins lead to the activation of two main signaling pathways: the PI3K-AKT/PKB pathway, which is responsible for most of the metabolic actions of insulin, and the Ras-MAPK pathway, which regulates expression of some genes and cooperates with the PI3K pathway to control cell growth and differentiation. Binding of the SH2 domains of PI3K to phosphotyrosines on IRS1 leads to the activation of PI3K and the generation of phosphatidylinositol-(3, 4, 5)-triphosphate (PIP3), a lipid second messenger, which activates several PIP3-dependent serine/threonine kinases, such as PDPK1 and subsequently AKT/PKB. The net effect of this pathway is to produce a translocation of the glucose transporter SLC2A4/GLUT4 from cytoplasmic vesicles to the cell membrane to facilitate glucose transport. Moreover, upon insulin stimulation, activated AKT/PKB is responsible for: anti-apoptotic effect of insulin by inducing phosphorylation of BAD. regulates the expressi

Rabbit SR: dog, human, rat
Immunogen: Synthetic peptide corresponding to aa59-75, HLQILLMFKTRPEDFRD to human Insulin receptor (isoform Long).
USBio
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100 µg

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544 €

I7661-25G.500
IP, Neutralization Erklärungen der Abkürzungen ansehen.
Mouse IgG2a SR: bovine, human, swine, sheep
USBio
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500 µl

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540 €

I7661-25GX.100
ELISA, IP, Neutr. Erklärungen der Abkürzungen ansehen.
Mouse IgG2a SR: human
USBio
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100 µl

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584 €

I7661-25H.500
IHC, FC Erklärungen der Abkürzungen ansehen.
Mouse kappa kappa SR: bovine, human, swine, rabbit, sheep
USBio
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500 µl

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540 €

I7661-25HX.100
ELISA, IHC, FC Erklärungen der Abkürzungen ansehen.
Mouse kappa kappa SR: bovine, human, swine, rabbit, sheep
USBio
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100 µl

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584 €

I7661-25J.500
Neutr. Erklärungen der Abkürzungen ansehen.
Mouse IgG1 SR: bovine, human, swine, sheep
USBio
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500 µl

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540 €

I7661-25JX.100
Mouse IgG1 SR: bovine, human, swine, sheep
USBio
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100 µl

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575 €

I7661-25L.100
WB, IHC Erklärungen der Abkürzungen ansehen.
Receptor tyrosine kinase which mediates the pleiotropic actions of insulin. Binding of insulin leads to phosphorylation of several intracellular substrates, including, insulin receptor substrates (IRS1, 2, 3, 4), SHC, GAB1, CBL and other signaling intermediates. Each of these phosphorylated proteins serve as docking proteins for other signaling proteins that contain Src-homology-2 domains (SH2 domain) that specifically recognize different phosphotyrosines residues, including the p85 regulatory subunit of PI3K and SHP2. Phosphorylation of IRSs proteins lead to the activation of two main signaling pathways: the PI3K-AKT/PKB pathway, which is responsible for most of the metabolic actions of insulin, and the Ras-MAPK pathway, which regulates expression of some genes and cooperates with the PI3K pathway to control cell growth and differentiation. Binding of the SH2 domains of PI3K to phosphotyrosines on IRS1 leads to the activation of PI3K and the generation of phosphatidylinositol-(3, 4, 5)-triphosphate (PIP3), a lipid second messenger, which activates several PIP3-dependent serine/threonine kinases, such as PDPK1 and subsequently AKT/PKB. The net effect of this pathway is to produce a translocation of the glucose transporter SLC2A4/GLUT4 from cytoplasmic vesicles to the cell membrane to facilitate glucose transport. Moreover, upon insulin stimulation, activated AKT/PKB is responsible for: anti-apoptotic effect of insulin by inducing phosphorylation of BAD. regulates the expressi

Rabbit IgG SR: dog, human, mouse, rat
Immunogen: Synthetic peptide corresponding to a sequence at the N-terminal of human Insulin R alpha, identical to the related rat and mouse sequence.
USBio
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100 µg

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445 €

I7661-26C.100
related products

WB, IP Erklärungen der Abkürzungen ansehen.
Receptor tyrosine kinase which mediates the pleiotropic actions of insulin. Binding of insulin leads to phosphorylation of several intracellular substrates, including, insulin receptor substrates (IRS1, 2, 3, 4), SHC, GAB1, CBL and other signaling intermediates. Each of these phosphorylated proteins serve as docking proteins for other signaling proteins that contain Src-homology-2 domains (SH2 domain) that specifically recognize different phosphotyrosines residues, including the p85 regulatory subunit of PI3K and SHP2. Phosphorylation of IRSs proteins lead to the activation of two main signaling pathways: the PI3K-AKT/PKB pathway, which is responsible for most of the metabolic actions of insulin, and the Ras-MAPK pathway, which regulates expression of some genes and cooperates with the PI3K pathway to control cell growth and differentiation. Binding of the SH2 domains of PI3K to phosphotyrosines on IRS1 leads to the activation of PI3K and the generation of phosphatidylinositol-(3, 4, 5)-triphosphate (PIP3), a lipid second messenger, which activates several PIP3-dependent serine/threonine kinases, such as PDPK1 and subsequently AKT/PKB. The net effect of this pathway is to produce a translocation of the glucose transporter SLC2A4/GLUT4 from cytoplasmic vesicles to the cell membrane to facilitate glucose transport. Moreover, upon insulin stimulation, activated AKT/PKB is responsible for: anti-apoptotic effect of insulin by inducing phosphorylation of BAD. regulates the expressi

Rabbit SR: human, mouse, rat
Immunogen: GST-fusion protein corresponding to the last 100 C-terminal amino acid residues of the human insulin receptor beta chain.
USBio
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100 µl

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601 €

I7661-26K.10
Enzyme assays Erklärungen der Abkürzungen ansehen.
Receptor tyrosine kinase which mediates the pleiotropic actions of insulin. Binding of insulin leads to phosphorylation of several intracellular substrates, including, insulin receptor substrates (IRS1, 2, 3, 4), SHC, GAB1, CBL and other signaling intermediates. Each of these phosphorylated proteins serve as docking proteins for other signaling proteins that contain Src-homology-2 domains (SH2 domain) that specifically recognize different phosphotyrosines residues, including the p85 regulatory subunit of PI3K and SHP2. Phosphorylation of IRSs proteins lead to the activation of two main signaling pathways: the PI3K-AKT/PKB pathway, which is responsible for most of the metabolic actions of insulin, and the Ras-MAPK pathway, which regulates expression of some genes and cooperates with the PI3K pathway to control cell growth and differentiation. Binding of the SH2 domains of PI3K to phosphotyrosines on IRS1 leads to the activation of PI3K and the generation of phosphatidylinositol-(3, 4, 5)-triphosphate (PIP3), a lipid second messenger, which activates several PIP3-dependent serine/threonine kinases, such as PDPK1 and subsequently AKT/PKB. The net effect of this pathway is to produce a translocation of the glucose transporter SLC2A4/GLUT4 from cytoplasmic vesicles to the cell membrane to facilitate glucose transport. Moreover, upon insulin stimulation, activated AKT/PKB is responsible for: anti-apoptotic effect of insulin by inducing phosphorylation of BAD. regulates the expressi
USBio
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10 µg

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516 €

I8700-25B.100
ELISA, WB, IP Erklärungen der Abkürzungen ansehen.
Purity: Purified by immunoaffinit
Mouse IgG2b SR: human, rat
Immunogen: Highly purified insulin receptors (alpha-subunit) from human term placentas.
USBio
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100 µl

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562 €

030455.100
ELISA, WB, IHC Erklärungen der Abkürzungen ansehen.
Protein function: Component of the post-replicative DNA mismatch repair system (MMR). Forms two different heterodimers: MutS alpha (MSH2- MSH6 heterodimer) and MutS beta (MSH2-MSH3 heterodimer) which binds to DNA mismatches thereby initiating DNA repair. When bound, heterodimers bend the DNA helix and shields approximately 20 base pairs. MutS alpha recognizes single base mismatches and dinucleotide insertion-deletion loops (IDL) in the DNA. MutS beta recognizes larger insertion-deletion loops up to 13 nucleotides long. After mismatch binding, MutS alpha or beta forms a ternary complex with the MutL alpha heterodimer, which is thought to be responsible for directing the downstream MMR events, including strand discrimination, excision, and resynthesis. ATP binding and hydrolysis play a pivotal role in mismatch repair functions. The ATPase activity associated with MutS alpha regulates binding similar to a molecular switch: mismatched DNA provokes ADP-->ATP exchange, resulting in a discernible conformational transition that converts MutS alpha into a sliding clamp capable of hydrolysis-independent diffusion along the DNA backbone. This transition is crucial for mismatch repair. MutS alpha may also play a role in DNA homologous recombination repair. In melanocytes may modulate both UV-B-induced cell cycle regulation and apoptosis. [The UniProt Consortium]

Mouse IgG1 SR: human, monkey
Immunogen: Purified recombinant fragment of human MSH2 expressed in E. coli.
USBio
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100 µl

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417 €

M4692-34A.100
WB Erklärungen der Abkürzungen ansehen.
Protein function: Component of the post-replicative DNA mismatch repair system (MMR). Forms two different heterodimers: MutS alpha (MSH2- MSH6 heterodimer) and MutS beta (MSH2-MSH3 heterodimer) which binds to DNA mismatches thereby initiating DNA repair. When bound, heterodimers bend the DNA helix and shields approximately 20 base pairs. MutS alpha recognizes single base mismatches and dinucleotide insertion-deletion loops (IDL) in the DNA. MutS beta recognizes larger insertion-deletion loops up to 13 nucleotides long. After mismatch binding, MutS alpha or beta forms a ternary complex with the MutL alpha heterodimer, which is thought to be responsible for directing the downstream MMR events, including strand discrimination, excision, and resynthesis. ATP binding and hydrolysis play a pivotal role in mismatch repair functions. The ATPase activity associated with MutS alpha regulates binding similar to a molecular switch: mismatched DNA provokes ADP-->ATP exchange, resulting in a discernible conformational transition that converts MutS alpha into a sliding clamp capable of hydrolysis-independent diffusion along the DNA backbone. This transition is crucial for mismatch repair. MutS alpha may also play a role in DNA homologous recombination repair. In melanocytes may modulate both UV-B-induced cell cycle regulation and apoptosis. [The UniProt Consortium]

Sheep IgG SR: human
Immunogen: Recombinant corresponding to aa2-140 from human MSH2 expressed in E. coli.
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100 µg

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712 €

M4692-34B.100
WB, IP, IHC Erklärungen der Abkürzungen ansehen.
Component of the post-replicative DNA mismatch repair system (MMR). Forms two different heterodimers: MutS alpha (MSH2-MSH6 heterodimer) and MutS beta (MSH2-MSH3 heterodimer) which binds to DNA mismatches thereby initiating DNA repair. When bound, heterodimers bend the DNA helix and shields approximately 20 base pairs. MutS alpha recognizes single base mismatches and dinucleotide insertion-deletion loops (IDL) in the DNA. MutS beta recognizes larger insertion-deletion loops up to 13 nucleotides long. After mismatch binding, MutS alpha or beta forms a ternary complex with the MutL alpha heterodimer, which is thought to be responsible for directing the downstream MMR events, including strand discrimination, excision, and resynthesis. ATP binding and hydrolysis play a pivotal role in mismatch repair functions. The ATPase activity associated with MutS alpha regulates binding similar to a molecular switch: mismatched DNA provokes ADP-->ATP exchange, resulting in a discernible conformational transition that converts MutS alpha into a sliding clamp capable of hydrolysis-independent diffusion along the DNA backbone. This transition is crucial for mismatch repair. MutS alpha may also play a role in DNA homologous recombination repair. In melanocytes may modulate both UV-B-induced cell cycle regulation and apoptosis. [The UniProt Consortium]

Rabbit IgG SR: human, mouse, rat
Immunogen: Synthetic peptide corresponding to aa1-50 from MSH2.
USBio
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100 µg

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456 €

034087.200
ELISA, WB, IHC Erklärungen der Abkürzungen ansehen.
Protein function: Type I collagen is a member of group I collagen (fibrillar forming collagen). [The UniProt Consortium]

Rabbit IgG SR: human, mouse
Immunogen: COL1A1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1076-1106 amino acids from the C-terminal region of human COL1A1.
USBio
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200 µl

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521 €

C7510-11Q1.50
neu

ELISA, WB, IHC Erklärungen der Abkürzungen ansehen.
Purity: Purified by Protein A aff
Mouse IgG3 kappa SR: human
Immunogen: Recombinant corresponding to human COL1A1.
USBio
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50 µg

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717 €

P9005-74.100
IHC Erklärungen der Abkürzungen ansehen.
Type I collagen is a member of group I collagen (fibrillar forming collagen). [The UniProt Consortium]

Mouse IgG1 SR: bovine, guinea pig, human
USBio
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100 µl

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601 €

030445.100
ELISA, WB, IHC Erklärungen der Abkürzungen ansehen.
Protein function: Heterodimerizes with PMS2 to form MutL alpha, a component of the post-replicative DNA mismatch repair system (MMR). DNA repair is initiated by MutS alpha (MSH2-MSH6) or MutS beta (MSH2-MSH6) binding to a dsDNA mismatch, then MutL alpha is recruited to the heteroduplex. Assembly of the MutL-MutS- heteroduplex ternary complex in presence of RFC and PCNA is sufficient to activate endonuclease activity of PMS2. It introduces single-strand breaks near the mismatch and thus generates new entry points for the exonuclease EXO1 to degrade the strand containing the mismatch. DNA methylation would prevent cleavage and therefore assure that only the newly mutated DNA strand is going to be corrected. MutL alpha (MLH1-PMS2) interacts physically with the clamp loader subunits of DNA polymerase III, suggesting that it may play a role to recruit the DNA polymerase III to the site of the MMR. Also implicated in DNA damage signaling, a process which induces cell cycle arrest and can lead to apoptosis in case of major DNA damages. Heterodimerizes with MLH3 to form MutL gamma which plays a role in meiosis. [The UniProt Consortium]

Mouse IgG1 SR: human, monkey
Immunogen: Purified recombinant fragment of MLH1 (aa381-483) expressed in E. coli.
USBio
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100 µl

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454 €

031124.100
neu

ELISA, WB Erklärungen der Abkürzungen ansehen.
Purity: Ascites
Mouse IgG1 SR: human
Immunogen: MLH1 Mab is generated from mouses immunized with a KLH conjugated synthetic peptide selected from human MLH1.
USBio
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100 µl

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482 €

M3949-60C.100
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Heterodimerizes with PMS2 to form MutL alpha, a component of the post-replicative DNA mismatch repair system (MMR). DNA repair is initiated by MutS alpha (MSH2-MSH6) or MutS beta (MSH2-MSH6) binding to a dsDNA mismatch, then MutL alpha is recruited to the heteroduplex. Assembly of the MutL-MutS-heteroduplex ternary complex in presence of RFC and PCNA is sufficient to activate endonuclease activity of PMS2. It introduces single-strand breaks near the mismatch and thus generates new entry points for the exonuclease EXO1 to degrade the strand containing the mismatch. DNA methylation would prevent cleavage and therefore assure that only the newly mutated DNA strand is going to be corrected. MutL alpha (MLH1-PMS2) interacts physically with the clamp loader subunits of DNA polymerase III, suggesting that it may play a role to recruit the DNA polymerase III to the site of the MMR. Also implicated in DNA damage signaling, a process which induces cell cycle arrest and can lead to apoptosis in case of major DNA damages. Heterodimerizes with MLH3 to form MutL gamma which plays a role in meiosis. [The UniProt Consortium]

Rabbit IgG SR: human, monkey
Immunogen: Synthetic peptide corresponding to residues near the amino terminus of human MLH1 protein (KLH-coupled).
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030205.100
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Protein function: Factor VIII, along with calcium and phospholipid, acts as a cofactor for factor IXa when it converts factor X to the activated form, factor Xa. [The UniProt Consortium]

Mouse IgG1 SR: human
Immunogen: Purified recombinant fragment of F8 expressed in E. coli.
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454 €

F0016-03A.200
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Mouse IgG1 SR: human
Immunogen: Purified human Factor VIII.
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200 µg

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537 €

F0016-03F.500
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Mouse IgG1 SR: human
Immunogen: Human Factor VIII.
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500 µg

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1000 €

F0016-03H.5
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Mouse IgG1 SR: human
Immunogen: Human Factor VIII.
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5 ml

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701 €

F0016-03J.500
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Mouse IgG1 SR: human
Immunogen: Von Willebrand factor isolated from human plasma. Cellular Localization: Cytoplasmic.
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500 µl

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596 €

F0016-03K.50
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Mouse IgG1 SR: human
Immunogen: Purified human Factor VIII
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50 µg

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642 €

F0016-07.500
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Mouse IgG1 SR: human, swine
Immunogen: Human Factor VIII
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500 µg

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595 €

F0016-07B.1
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Mouse IgG1 SR: human
Immunogen: Human Factor VIII
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1 ml

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1007 €

F0016-07C.250
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Purity: Purified
Mouse IgG1 SR: human, swine
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250 µg

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842 €

F0016-10.1
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Sheep SR: human
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1 mg

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406 €

F0016-10.100
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Sheep SR: human
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100 µg

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176 €

F0016-10A.500
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Mouse IgG1 SR: human
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500 µl

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522 €

F0016-10E.500
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Mouse IgG1 SR: human
Immunogen: Human Factor VIII A2 domain.
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802 €

F0016-13.500
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Rabbit SR: human
USBio
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500 µl

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327 €

F0016-13A.1
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Purity: Purified
Sheep IgG SR: human
Immunogen: Human Von Willebrand Factor Antigen prepared from citrated human plasma. Greater than 95% purity by SDS-PAGE.
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1 ml

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640 €

F0016-13C.500
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Purity: Purified
Rabbit IgG SR: human
Immunogen: Purified antisera of the von Willebrand Factor (factor VIII R:ag) related antigen in plasma.
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500 µl

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288 €

F0016-13D.1
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Purity: Purified by immunoaffinit
Sheep IgG SR: human
Immunogen: Human Von Willebrand Factor Antigen prepared from citrated human plasma. Greater than 95% purity by SDS-PAGE.
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697 €

F0016-15.500
ELISA Erklärungen der Abkürzungen ansehen. IgG2a SR: human
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500 µg

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479 €

F0016-17A.5
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Mouse SR: human
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5 ml

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582 €

F0016-18.1
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Mouse IgG2a kappa SR: human
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1 ml

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735 €

F0016-18.100
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Mouse IgG2a kappa SR: human
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100 µl

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213 €

F0016-18A.500
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Mouse IgG2a SR: human
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500 µl

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522 €

F0016-29.200
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Mouse IgG2a SR: human
Immunogen: Purified human factor VIII.
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200 µg

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516 €

F0016-30.1
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Sheep IgG SR: human
USBio
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1 mg

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181 €

F0016-30B.200
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Sheep IgG SR: human
USBio
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200 µg

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518 €

F0016.1
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Mouse IgG1 SR: human
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1 mg

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635 €

030398.100
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Protein function: Lamins are components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane, which is thought to provide a framework for the nuclear envelope and may also interact with chromatin. Lamin A and C are present in equal amounts in the lamina of mammals. Plays an important role in nuclear assembly, chromatin organization, nuclear membrane and telomere dynamics. [The UniProt Consortium]

Mouse IgG1 SR: human, mouse, rat
Immunogen: Purified recombinant fragment of human LMNA expressed in E. coli.
USBio
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100 µl

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482 €

031380.100
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Purity: Purified by affinity chro
Mouse IgG1 SR: bovine, human, mouse, swine, rat
Immunogen: Full length recombinant human Lamin C
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100 µl

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504 €

037834.200
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Protein function: Lamins are components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane, which is thought to provide a framework for the nuclear envelope and may also interact with chromatin. Lamin A and C are present in equal amounts in the lamina of mammals. Plays an important role in nuclear assembly, chromatin organization, nuclear membrane and telomere dynamics. [The UniProt Consortium]

Rabbit IgG SR: human
Immunogen: LMNA antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 400-427 amino acids from the Central region of human LMNA.
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L1220-08F.100
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Lamins are components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane, which is thought to provide a framework for the nuclear envelope and may also interact with chromatin. Lamin A and C are present in equal amounts in the lamina of mammals. Play an important role in nuclear assembly, chromatin organization, nuclear membrane and telomere dynamics. [The UniProt Consortium]

Rabbit IgG SR: human, mouse, rat
Immunogen: Synthetic peptide corresponding to aa 451-468, FVRLRNKSNEDQSMGNWQ to human Lamin A and Lamin C.
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544 €

L1220-08G.50
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Mouse IgG1 SR: human
Immunogen: Recombinant corresponding to human Lamin A.
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50 µl

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642 €

L1220-08J.100
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Lamins are components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane, which is thought to provide a framework for the nuclear envelope and may also interact with chromatin. Lamin A and C are present in equal amounts in the lamina of mammals. Plays an important role in nuclear assembly, chromatin organization, nuclear membrane and telomere dynamics. [The UniProt Consortium]

Rabbit IgG SR: human, mouse, rat
Immunogen: Synthetic peptide corresponding to aa220 from human Lamin A.
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456 €

N0530-18B.100
IHC Erklärungen der Abkürzungen ansehen.
This protein mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na() ions may pass in accordance with their electrochemical gradient. It is a tetrodotoxin-resistant Na() channel isoform. This channel is responsible for the initial upstroke of the action potential. Channel inactivation is regulated by intracellular calcium levels. [The UniProt Consortium]

Goat IgG
Immunogen: Synthetic peptide corresponding to C-ETDDQSPEKIN, from the Internal of the protein sequence according to NP_932173.1, NP_000326, NP_001092875.
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668 €

029467.100
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Nuclear hormone receptor. The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Ligand-dependent nuclear transactivation involves either direct homodimer binding to a palindromic estrogen response element (ERE) sequence or association with other DNA-binding transcription factors, such as AP-1/c-Jun, c-Fos, ATF-2, Sp1 and Sp3, to mediate ERE-independent signaling. Ligand binding induces a conformational change allowing subsequent or combinatorial association with multiprotein coactivator complexes through LXXLL motifs of their respective components. Mutual transrepression occurs between the estrogen receptor (ER) and NF-kappa-B in a cell-type specific manner. Decreases NF-kappa-B DNA-binding activity and inhibits NF-kappa-B-mediated transcription from the IL6 promoter and displace RELA/p65 and associated coregulators from the promoter. Recruited to the NF-kappa-B response element of the CCL2 and IL8 promoters and can displace CREBBP. Present with NF-kappa-B components RELA/p65 and NFKB1/p50 on ERE sequences. Can also act synergistically with NF-kappa-B to activate transcription involving respective recruitment adjacent response elements. the function involves CREBBP. Can activate the transcriptional activity of TFF1. Also mediates membrane-initiated estrogen signaling involving various kinase cascades. Isoform 3 is involved in activation of NOS3 and endothel

Rabbit IgG SR: human
Immunogen: Synthetic linear peptide corresponding to human Estrogen Receptor alpha phosphorylated at Ser305 (KLH).
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100 µg

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628 €

030186.100
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Protein function: Nuclear hormone receptor. The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Ligand-dependent nuclear transactivation involves either direct homodimer binding to a palindromic estrogen response element (ERE) sequence or association with other DNA- binding transcription factors, such as AP-1/c-Jun, c-Fos, ATF-2, Sp1 and Sp3, to mediate ERE-independent signaling. Ligand binding induces a conformational change allowing subsequent or combinatorial association with multiprotein coactivator complexes through LXXLL motifs of their respective components. Mutual transrepression occurs between the estrogen receptor (ER) and NF- kappa-B in a cell-type specific manner. Decreases NF-kappa-B DNA- binding activity and inhibits NF-kappa-B-mediated transcription from the IL6 promoter and displace RELA/p65 and associated coregulators from the promoter. Recruited to the NF-kappa-B response element of the CCL2 and IL8 promoters and can displace CREBBP. Present with NF-kappa-B components RELA/p65 and NFKB1/p50 on ERE sequences. Can also act synergistically with NF-kappa-B to activate transcription involving respective recruitment adjacent response elements, the function involves CREBBP. Can activate the transcriptional activity of TFF1. Also mediates membrane-initiated estrogen signaling involving various kinase cascades. Isoform 3 is involved in activation

Mouse IgG1 SR: human
Immunogen: Purified recombinant fragment of human ER-alpha (410-592aa) expressed in E. coli.
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100 µl

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361 €

030195.100
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Protein function: Nuclear hormone receptor. The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Ligand-dependent nuclear transactivation involves either direct homodimer binding to a palindromic estrogen response element (ERE) sequence or association with other DNA- binding transcription factors, such as AP-1/c-Jun, c-Fos, ATF-2, Sp1 and Sp3, to mediate ERE-independent signaling. Ligand binding induces a conformational change allowing subsequent or combinatorial association with multiprotein coactivator complexes through LXXLL motifs of their respective components. Mutual transrepression occurs between the estrogen receptor (ER) and NF- kappa-B in a cell-type specific manner. Decreases NF-kappa-B DNA- binding activity and inhibits NF-kappa-B-mediated transcription from the IL6 promoter and displace RELA/p65 and associated coregulators from the promoter. Recruited to the NF-kappa-B response element of the CCL2 and IL8 promoters and can displace CREBBP. Present with NF-kappa-B components RELA/p65 and NFKB1/p50 on ERE sequences. Can also act synergistically with NF-kappa-B to activate transcription involving respective recruitment adjacent response elements, the function involves CREBBP. Can activate the transcriptional activity of TFF1. Also mediates membrane-initiated estrogen signaling involving various kinase cascades. Isoform 3 is involved in activation

Mouse IgG1 SR: human
Immunogen: Purified recombinant fragment of ESR1 (aa301-595) expressed in E. coli.
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100 µl

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417 €

030196.100
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Protein function: Nuclear hormone receptor. The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Ligand-dependent nuclear transactivation involves either direct homodimer binding to a palindromic estrogen response element (ERE) sequence or association with other DNA- binding transcription factors, such as AP-1/c-Jun, c-Fos, ATF-2, Sp1 and Sp3, to mediate ERE-independent signaling. Ligand binding induces a conformational change allowing subsequent or combinatorial association with multiprotein coactivator complexes through LXXLL motifs of their respective components. Mutual transrepression occurs between the estrogen receptor (ER) and NF- kappa-B in a cell-type specific manner. Decreases NF-kappa-B DNA- binding activity and inhibits NF-kappa-B-mediated transcription from the IL6 promoter and displace RELA/p65 and associated coregulators from the promoter. Recruited to the NF-kappa-B response element of the CCL2 and IL8 promoters and can displace CREBBP. Present with NF-kappa-B components RELA/p65 and NFKB1/p50 on ERE sequences. Can also act synergistically with NF-kappa-B to activate transcription involving respective recruitment adjacent response elements, the function involves CREBBP. Can activate the transcriptional activity of TFF1. Also mediates membrane-initiated estrogen signaling involving various kinase cascades. Isoform 3 is involved in activation

Mouse IgG1 SR: human
Immunogen: Purified recombinant fragment of ESR1 (aa130-339) expressed in E. coli.
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454 €

030197.100
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Purity: Ascites
Mouse IgG1 SR: human
Immunogen: Synthetic peptide corresponding to aa(SLQKYYITGEAEGFPATVc) of human ESR1, conjugated to KLH.
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100 µl

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492 €

030198.100
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Protein function: Nuclear hormone receptor. The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Ligand-dependent nuclear transactivation involves either direct homodimer binding to a palindromic estrogen response element (ERE) sequence or association with other DNA- binding transcription factors, such as AP-1/c-Jun, c-Fos, ATF-2, Sp1 and Sp3, to mediate ERE-independent signaling. Ligand binding induces a conformational change allowing subsequent or combinatorial association with multiprotein coactivator complexes through LXXLL motifs of their respective components. Mutual transrepression occurs between the estrogen receptor (ER) and NF- kappa-B in a cell-type specific manner. Decreases NF-kappa-B DNA- binding activity and inhibits NF-kappa-B-mediated transcription from the IL6 promoter and displace RELA/p65 and associated coregulators from the promoter. Recruited to the NF-kappa-B response element of the CCL2 and IL8 promoters and can displace CREBBP. Present with NF-kappa-B components RELA/p65 and NFKB1/p50 on ERE sequences. Can also act synergistically with NF-kappa-B to activate transcription involving respective recruitment adjacent response elements, the function involves CREBBP. Can activate the transcriptional activity of TFF1. Also mediates membrane-initiated estrogen signaling involving various kinase cascades. Isoform 3 is involved in activation

Mouse IgG1 SR: human
Immunogen: Purified recombinant fragment of human ESR1 expressed in E. coli.
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454 €

030950.100
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Purity: Ascites
Mouse IgG1 SR: human
Immunogen: Purified His-tagged ESR1/ER protein (fragment).
USBio
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100 µl

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482 €

030951.100
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Protein function: Nuclear hormone receptor. The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Ligand-dependent nuclear transactivation involves either direct homodimer binding to a palindromic estrogen response element (ERE) sequence or association with other DNA- binding transcription factors, such as AP-1/c-Jun, c-Fos, ATF-2, Sp1 and Sp3, to mediate ERE-independent signaling. Ligand binding induces a conformational change allowing subsequent or combinatorial association with multiprotein coactivator complexes through LXXLL motifs of their respective components. Mutual transrepression occurs between the estrogen receptor (ER) and NF- kappa-B in a cell-type specific manner. Decreases NF-kappa-B DNA- binding activity and inhibits NF-kappa-B-mediated transcription from the IL6 promoter and displace RELA/p65 and associated coregulators from the promoter. Recruited to the NF-kappa-B response element of the CCL2 and IL8 promoters and can displace CREBBP. Present with NF-kappa-B components RELA/p65 and NFKB1/p50 on ERE sequences. Can also act synergistically with NF-kappa-B to activate transcription involving respective recruitment adjacent response elements, the function involves CREBBP. Can activate the transcriptional activity of TFF1. Also mediates membrane-initiated estrogen signaling involving various kinase cascades. Isoform 3 is involved in activation

Purity: Purified by Protein G aff
Mouse IgG1 SR: human
Immunogen: Purified His-tagged ESR1 protein (fragment).
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100 µg

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464 €

E3564-75A.100
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Nuclear hormone receptor. The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Can activate the transcriptional activity of TFF1. [The UniProt Consortium]

Rabbit IgG SR: human
Immunogen: Synthetic phosphopeptide corresponding to residues surrounding S118 of human ER alpha (Accession # P03372).
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100 µg

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603 €

E3565-06M.500
IHC Erklärungen der Abkürzungen ansehen.
Nuclear hormone receptor. The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Ligand-dependent nuclear transactivation involves either direct homodimer binding to a palindromic estrogen response element (ERE) sequence or association with other DNA-binding transcription factors, such as AP-1/c-Jun, c-Fos, ATF-2, Sp1 and Sp3, to mediate ERE-independent signaling. Ligand binding induces a conformational change allowing subsequent or combinatorial association with multiprotein coactivator complexes through LXXLL motifs of their respective components. Mutual transrepression occurs between the estrogen receptor (ER) and NF-kappa-B in a cell-type specific manner. Decreases NF-kappa-B DNA-binding activity and inhibits NF-kappa-B-mediated transcription from the IL6 promoter and displace RELA/p65 and associated coregulators from the promoter. Recruited to the NF-kappa-B response element of the CCL2 and IL8 promoters and can displace CREBBP. Present with NF-kappa-B components RELA/p65 and NFKB1/p50 on ERE sequences. Can also act synergistically with NF-kappa-B to activate transcription involving respective recruitment adjacent response elements. the function involves CREBBP. Can activate the transcriptional activity of TFF1. Also mediates membrane-initiated estrogen signaling involving various kinase cascades. Isoform 3 is involved in activation of NOS3 and endothel

Rabbit IgG SR: hamster, human, mouse, rat
Immunogen: Synthetic peptide derived from C-terminus of human Estrogen Receptor.
USBio
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500 µl

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979 €

E3565-09B.50
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WB Erklärungen der Abkürzungen ansehen.
Nuclear hormone receptor. The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Can activate the transcriptional activity of TFF1. [The UniProt Consortium]

Chicken SR: human, mouse, rat
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547 €

E3565-09E.100
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Nuclear hormone receptor. The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Can activate the transcriptional activity of TFF1. [The UniProt Consortium]

Rabbit IgG SR: human
Immunogen: A synthetic peptide corresponding to residues on the C-terminus of human ERalpha.
USBio
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100 µl

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537 €

E3565-10A1.100
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WB Erklärungen der Abkürzungen ansehen.
Nuclear hormone receptor. The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Can activate the transcriptional activity of TFF1. [The UniProt Consortium]

Rabbit IgG SR: human, monkey
Immunogen: Synthetic phosphopeptide corresponding to residues surrounding Ser167 of human estrogen receptor a.
USBio
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100 µl

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489 €

E3565-10K1.100
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WB Erklärungen der Abkürzungen ansehen.
Nuclear hormone receptor. The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Can activate the transcriptional activity of TFF1. [The UniProt Consortium]

Sheep IgG SR: human
Immunogen: Recombinant human Estrogen receptor alpha aa 1-116, P03372 (E.coli).
USBio
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100 µg

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712 €

E3565-10Q1.100
WB Erklärungen der Abkürzungen ansehen.
Nuclear hormone receptor. The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Can activate the transcriptional activity of TFF1. [The UniProt Consortium]

Mouse IgG2B SR: human
Immunogen: Recombinant corresponding to aa1-116 from human ERa/NR3A1 expressed in E. coli (P03372).
USBio
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100 µg

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535 €

E3565-11N.100
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WB, ICC Erklärungen der Abkürzungen ansehen.
Nuclear hormone receptor. The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Can activate the transcriptional activity of TFF1. [The UniProt Consortium]

Purity: Supernatant
Rabbit IgG SR: human
Immunogen: A phospho-specific peptide corresponding to residues surrounding Serine 104/106 of human ER alpha.
USBio
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100 µl

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537 €

E3565-11P.100
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WB Erklärungen der Abkürzungen ansehen.
Nuclear hormone receptor. The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Can activate the transcriptional activity of TFF1. [The UniProt Consortium]

Purity: Supernatant
Rabbit IgG SR: human
Immunogen: A phospho-specific peptide corresponding to residues surrounding Serine 167 of human ER alpha.
USBio
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100 µl

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586 €

E3565-11W.50
WB, IHC, IF Erklärungen der Abkürzungen ansehen.
Nuclear hormone receptor. The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Ligand-dependent nuclear transactivation involves either direct homodimer binding to a palindromic estrogen response element (ERE) sequence or association with other DNA-binding transcription factors, such as AP-1/c-Jun, c-Fos, ATF-2, Sp1 and Sp3, to mediate ERE-independent signaling. Ligand binding induces a conformational change allowing subsequent or combinatorial association with multiprotein coactivator complexes through LXXLL motifs of their respective components. Mutual transrepression occurs between the estrogen receptor (ER) and NF-kappa-B in a cell-type specific manner. Decreases NF-kappa-B DNA-binding activity and inhibits NF-kappa-B-mediated transcription from the IL6 promoter and displace RELA/p65 and associated coregulators from the promoter. Recruited to the NF-kappa-B response element of the CCL2 and IL8 promoters and can displace CREBBP. Present with NF-kappa-B components RELA/p65 and NFKB1/p50 on ERE sequences. Can also act synergistically with NF-kappa-B to activate transcription involving respective recruitment adjacent response elements. the function involves CREBBP. Can activate the transcriptional activity of TFF1. Also mediates membrane-initiated estrogen signaling involving various kinase cascades. Isoform 3 is involved in activation of NOS3 and endothel

Rabbit IgG SR: human, mouse, rat
Immunogen: Estrogen Receptor alpha phosphorylated at Ser106.
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50 µg

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396 €

E3565-11X.50
WB, IHC, IF Erklärungen der Abkürzungen ansehen.
Nuclear hormone receptor. The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Ligand-dependent nuclear transactivation involves either direct homodimer binding to a palindromic estrogen response element (ERE) sequence or association with other DNA-binding transcription factors, such as AP-1/c-Jun, c-Fos, ATF-2, Sp1 and Sp3, to mediate ERE-independent signaling. Ligand binding induces a conformational change allowing subsequent or combinatorial association with multiprotein coactivator complexes through LXXLL motifs of their respective components. Mutual transrepression occurs between the estrogen receptor (ER) and NF-kappa-B in a cell-type specific manner. Decreases NF-kappa-B DNA-binding activity and inhibits NF-kappa-B-mediated transcription from the IL6 promoter and displace RELA/p65 and associated coregulators from the promoter. Recruited to the NF-kappa-B response element of the CCL2 and IL8 promoters and can displace CREBBP. Present with NF-kappa-B components RELA/p65 and NFKB1/p50 on ERE sequences. Can also act synergistically with NF-kappa-B to activate transcription involving respective recruitment adjacent response elements. the function involves CREBBP. Can activate the transcriptional activity of TFF1. Also mediates membrane-initiated estrogen signaling involving various kinase cascades. Isoform 3 is involved in activation of NOS3 and endothel

Rabbit IgG SR: human, mouse
Immunogen: Estrogen Receptor alpha phosphorylated at Ser118.
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E3565-11Z1.100
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Nuclear hormone receptor. The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Can activate the transcriptional activity of TFF1. [The UniProt Consortium]

Mouse IgG2B
Immunogen: Recombinant corresponding to aa2-116 from human ERa expressed in E. coli (P03372).
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E3565-15C.100
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Nuclear hormone receptor. Binds estrogens with an affinity similar to that of ESR1, and activates expression of reporter genes containing estrogen response elements (ERE) in an estrogen-dependent manner. Isoform beta-cx lacks ligand binding ability and has no or only very low ere binding activity resulting in the loss of ligand-dependent transactivation ability. DNA-binding by ESR1 and ESR2 is rapidly lost at 37 degrees Celsius in the absence of ligand while in the presence of 17 beta-estradiol and 4-hydroxy-tamoxifen loss in DNA-binding at elevated temperature is more gradual. [The UniProt Consortium]

Rabbit IgG SR: human
Immunogen: Synthetic peptide corresponding to aa63-82 of rat and mouse estrogen receptor b and aa55-74 of human estrogen receptor b, conjugated to KLH. Cellular Localization: Nucleus.
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136380.50
neu

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Rabbit SR: human
Immunogen: Synthetic peptide corresponding to human RET at C-Terminalconjugated to KLH.
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R1636-90D.50
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Protein function: Receptor tyrosine-protein kinase involved in numerous cellular mechanisms including cell proliferation, neuronal navigation, cell migration, and cell differentiation upon binding with glial cell derived neurotrophic factor family ligands. Phosphorylates PTK2/FAK1. Regulates both cell death/survival balance and positional information. Required for the molecular mechanisms orchestration during intestine organogenesis, involved in the development of enteric nervous system and renal organogenesis during embryonic life, and promotes the formation of Peyer's patch-like structures, a major component of the gut- associated lymphoid tissue. Modulates cell adhesion via its cleavage by caspase in sympathetic neurons and mediates cell migration in an integrin (e.g. ITGB1 and ITGB3)-dependent manner. Involved in the development of the neural crest. Active in the absence of ligand, triggering apoptosis through a mechanism that requires receptor intracellular caspase cleavage. Acts as a dependence receptor, in the presence of the ligand GDNF in somatotrophs (within pituitary), promotes survival and down regulates growth hormone (GH) production, but triggers apoptosis in absence of GDNF. Regulates nociceptor survival and size. Triggers the differentiation of rapidly adapting (RA) mechanoreceptors. Mediator of several diseases such as neuroendocrine cancers, these diseases are characterized by aberrant integrins-regulated cell migration. [The UniProt Consortium]

Mouse IgG1 SR: human
Immunogen: Recombinant corresponding to purified truncated RET (aa896-1063)-GST fusion protein, expressed in E. coli strain BL21 (DE3).
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R1637-10B.100
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Receptor tyrosine-protein kinase involved in numerous cellular mechanisms including cell proliferation, neuronal navigation, cell migration, and cell differentiation upon binding with glial cell derived neurotrophic factor family ligands. Phosphorylates PTK2/FAK1. Regulates both cell death/survival balance and positional information. Required for the molecular mechanisms orchestration during intestine organogenesis. involved in the development of enteric nervous system and renal organogenesis during embryonic life, and promotes the formation of Peyer's patch-like structures, a major component of the gut-associated lymphoid tissue. Modulates cell adhesion via its cleavage by caspase in sympathetic neurons and mediates cell migration in an integrin (e.g. ITGB1 and ITGB3)-dependent manner. Involved in the development of the neural crest. Active in the absence of ligand, triggering apoptosis through a mechanism that requires receptor intracellular caspase cleavage. Act as a dependence receptor. in the presence of the ligand GDNF in somatotrophs (within pituitary), promotes survival and down regulates growth hormone (GH) production, but triggers apoptosis in absence of GDNF. Regulates nociceptor survival and size. Triggers the differentiation of rapidly adapting (RA) mechanoreceptors. Mediator of several diseases such as neuroendocrine cancers. these diseases are characterized by aberrant integrins-regulated cell migration. [The UniProt Consortium]

Rabbit IgG SR: human
Immunogen: Synthetic peptide of amino acids surrounding the phosphoSerine 696 site of human c-ret. Cellular Localization: Membrane, Single-pass type I membrane protein.
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R1640-02.10
Enzyme assays Erklärungen der Abkürzungen ansehen.
Receptor tyrosine-protein kinase involved in numerous cellular mechanisms including cell proliferation, neuronal navigation, cell migration, and cell differentiation upon binding with glial cell derived neurotrophic factor family ligands. Phosphorylates PTK2/FAK1. Regulates both cell death/survival balance and positional information. Required for the molecular mechanisms orchestration during intestine organogenesis. involved in the development of enteric nervous system and renal organogenesis during embryonic life, and promotes the formation of Peyer's patch-like structures, a major component of the gut-associated lymphoid tissue. Modulates cell adhesion via its cleavage by caspase in sympathetic neurons and mediates cell migration in an integrin (e.g. ITGB1 and ITGB3)-dependent manner. Involved in the development of the neural crest. Active in the absence of ligand, triggering apoptosis through a mechanism that requires receptor intracellular caspase cleavage. Act as a dependence receptor. in the presence of the ligand GDNF in somatotrophs (within pituitary), promotes survival and down regulates growth hormone (GH) production, but triggers apoptosis in absence of GDNF. Regulates nociceptor survival and size. Triggers the differentiation of rapidly adapting (RA) mechanoreceptors. Mediator of several diseases such as neuroendocrine cancers. these diseases are characterized by aberrant integrins-regulated cell migration. [The UniProt Consortium]
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030929.100
neu

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Purity: Ascites
Mouse IgG1 SR: human
Immunogen: EGFR antibody is generated from mouses immunized with a KLH conjugated synthetic peptide between 1163-1191 amino acids from the C-terminal region of human EGFR.
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030930.100
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Protein function: Receptor tyrosine kinase binding ligands of the EGF family and activating several signaling cascades to convert extracellular cues into appropriate cellular responses. Known ligands include EGF, TGFA/TGF-alpha, amphiregulin, epigen/EPGN, BTC/betacellulin, epiregulin/EREG and HBEGF/heparin-binding EGF. Ligand binding triggers receptor homo- and/or heterodimerization and autophosphorylation on key cytoplasmic residues. The phosphorylated receptor recruits adapter proteins like GRB2 which in turn activates complex downstream signaling cascades. Activates at least 4 major downstream signaling cascades including the RAS- RAF-MEK-ERK, PI3 kinase-AKT, PLCgamma-PKC and STATs modules. May also activate the NF-kappa-B signaling cascade. Also directly phosphorylates other proteins like RGS16, activating its GTPase activity and probably coupling the EGF receptor signaling to the G protein-coupled receptor signaling. Also phosphorylates MUC1 and increases its interaction with SRC and CTNNB1/beta-catenin. [The UniProt Consortium]

Purity: Purified by Protein G aff
Mouse IgG1 SR: human
Immunogen: EGFR Mab is generated from mouses immunized with a KLH conjugated synthetic peptide selected from human EGFR.
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E3375-01E.50
IHC Erklärungen der Abkürzungen ansehen.
Receptor tyrosine kinase binding ligands of the EGF family and activating several signaling cascades to convert extracellular cues into appropriate cellular responses. Known ligands include EGF, TGFA/TGF-alpha, amphiregulin, epigen/EPGN, BTC/betacellulin, epiregulin/EREG and HBEGF/heparin-binding EGF. Ligand binding triggers receptor homo- and/or heterodimerization and autophosphorylation on key cytoplasmic residues. The phosphorylated receptor recruits adapter proteins like GRB2 which in turn activates complex downstream signaling cascades. Activates at least 4 major downstream signaling cascades including the RAS-RAF-MEK-ERK, PI3 kinase-AKT, PLCgamma-PKC and STATs modules. May also activate the NF-kappa-B signaling cascade. Also directly phosphorylates other proteins like RGS16, activating its GTPase activity and probably coupling the EGF receptor signaling to the G protein-coupled receptor signaling. Also phosphorylates MUC1 and increases its interaction with SRC and CTNNB1/beta-catenin. [The UniProt Consortium]

Rabbit SR: human
Immunogen: Synthetic peptide, KLH-conjugated. Epitope: C-terminal domain of human
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E3375-01F.50
IHC Erklärungen der Abkürzungen ansehen.
Receptor tyrosine kinase binding ligands of the EGF family and activating several signaling cascades to convert extracellular cues into appropriate cellular responses. Known ligands include EGF, TGFA/TGF-alpha, amphiregulin, epigen/EPGN, BTC/betacellulin, epiregulin/EREG and HBEGF/heparin-binding EGF. Ligand binding triggers receptor homo- and/or heterodimerization and autophosphorylation on key cytoplasmic residues. The phosphorylated receptor recruits adapter proteins like GRB2 which in turn activates complex downstream signaling cascades. Activates at least 4 major downstream signaling cascades including the RAS-RAF-MEK-ERK, PI3 kinase-AKT, PLCgamma-PKC and STATs modules. May also activate the NF-kappa-B signaling cascade. Also directly phosphorylates other proteins like RGS16, activating its GTPase activity and probably coupling the EGF receptor signaling to the G protein-coupled receptor signaling. Also phosphorylates MUC1 and increases its interaction with SRC and CTNNB1/beta-catenin. [The UniProt Consortium]

Rabbit SR: human
Immunogen: Synthetic peptide, KLH-conjugated. Epitope: C-terminal domain of human
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E3375-01G.50
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ELISA, WB, IHC Erklärungen der Abkürzungen ansehen.
Receptor tyrosine kinase binding ligands of the EGF family and activating several signaling cascades to convert extracellular cues into appropriate cellular responses. Known ligands include EGF, TGFA/TGF-alpha, amphiregulin, epigen/EPGN, BTC/betacellulin, epiregulin/EREG and HBEGF/heparin-binding EGF. Ligand binding triggers receptor homo- and/or heterodimerization and autophosphorylation on key cytoplasmic residues. The phosphorylated receptor recruits adapter proteins like GRB2 which in turn activates complex downstream signaling cascades. Activates at least 4 major downstream signaling cascades including the RAS-RAF-MEK-ERK, PI3 kinase-AKT, PLCgamma-PKC and STATs modules. May also activate the NF-kappa-B signaling cascade. Also directly phosphorylates other proteins like RGS16, activating its GTPase activity and probably coupling the EGF receptor signaling to the G protein-coupled receptor signaling. Also phosphorylates MUC1 and increases its interaction with SRC and CTNNB1/beta-catenin. [The UniProt Consortium]

Rabbit SR: human
Immunogen: Synthetic peptide, KLH-conjugated. Epitope: Amino acids 1189-1199 of human EGFR protein.
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E3375-01H.50
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Receptor tyrosine kinase binding ligands of the EGF family and activating several signaling cascades to convert extracellular cues into appropriate cellular responses. Known ligands include EGF, TGFA/TGF-alpha, amphiregulin, epigen/EPGN, BTC/betacellulin, epiregulin/EREG and HBEGF/heparin-binding EGF. Ligand binding triggers receptor homo- and/or heterodimerization and autophosphorylation on key cytoplasmic residues. The phosphorylated receptor recruits adapter proteins like GRB2 which in turn activates complex downstream signaling cascades. Activates at least 4 major downstream signaling cascades including the RAS-RAF-MEK-ERK, PI3 kinase-AKT, PLCgamma-PKC and STATs modules. May also activate the NF-kappa-B signaling cascade. Also directly phosphorylates other proteins like RGS16, activating its GTPase activity and probably coupling the EGF receptor signaling to the G protein-coupled receptor signaling. Also phosphorylates MUC1 and increases its interaction with SRC and CTNNB1/beta-catenin. [The UniProt Consortium]

Rabbit SR: human
Immunogen: Synthetic peptide, KLH-conjugated. Epitope: Amino acids 1189-1199 of human EGFR protein.
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50 µg

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642 €

E3375-04A.100
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WB, IP, IHC, ICC Erklärungen der Abkürzungen ansehen.
Receptor tyrosine kinase binding ligands of the EGF family and activating several signaling cascades to convert extracellular cues into appropriate cellular responses. Known ligands include EGF, TGFA/TGF-alpha, amphiregulin, epigen/EPGN, BTC/betacellulin, epiregulin/EREG and HBEGF/heparin-binding EGF. Ligand binding triggers receptor homo- and/or heterodimerization and autophosphorylation on key cytoplasmic residues. The phosphorylated receptor recruits adapter proteins like GRB2 which in turn activates complex downstream signaling cascades. Activates at least 4 major downstream signaling cascades including the RAS-RAF-MEK-ERK, PI3 kinase-AKT, PLCgamma-PKC and STATs modules. May also activate the NF-kappa-B signaling cascade. Also directly phosphorylates other proteins like RGS16, activating its GTPase activity and probably coupling the EGF receptor signaling to the G protein-coupled receptor signaling. Also phosphorylates MUC1 and increases its interaction with SRC and CTNNB1/beta-catenin. [The UniProt Consortium]

Purity: Supernatant
Rabbit IgG SR: human, mouse, rat
Immunogen: A synthetic phospho-peptide corresponding to residues surrounding Tyr1068 of human EGF receptor.
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E3375-04B.100
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WB, ICC, FC Erklärungen der Abkürzungen ansehen.
Receptor tyrosine kinase binding ligands of the EGF family and activating several signaling cascades to convert extracellular cues into appropriate cellular responses. Known ligands include EGF, TGFA/TGF-alpha, amphiregulin, epigen/EPGN, BTC/betacellulin, epiregulin/EREG and HBEGF/heparin-binding EGF. Ligand binding triggers receptor homo- and/or heterodimerization and autophosphorylation on key cytoplasmic residues. The phosphorylated receptor recruits adapter proteins like GRB2 which in turn activates complex downstream signaling cascades. Activates at least 4 major downstream signaling cascades including the RAS-RAF-MEK-ERK, PI3 kinase-AKT, PLCgamma-PKC and STATs modules. May also activate the NF-kappa-B signaling cascade. Also directly phosphorylates other proteins like RGS16, activating its GTPase activity and probably coupling the EGF receptor signaling to the G protein-coupled receptor signaling. Also phosphorylates MUC1 and increases its interaction with SRC and CTNNB1/beta-catenin. [The UniProt Consortium]

Purity: Supernatant
Rabbit IgG SR: human, mouse
Immunogen: A synthetic peptide corresponding to residues surrounding Tyr1068 of human EGF receptor.
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E3375-04C.100
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WB, IP, ICC Erklärungen der Abkürzungen ansehen.
Receptor tyrosine kinase binding ligands of the EGF family and activating several signaling cascades to convert extracellular cues into appropriate cellular responses. Known ligands include EGF, TGFA/TGF-alpha, amphiregulin, epigen/EPGN, BTC/betacellulin, epiregulin/EREG and HBEGF/heparin-binding EGF. Ligand binding triggers receptor homo- and/or heterodimerization and autophosphorylation on key cytoplasmic residues. The phosphorylated receptor recruits adapter proteins like GRB2 which in turn activates complex downstream signaling cascades. Activates at least 4 major downstream signaling cascades including the RAS-RAF-MEK-ERK, PI3 kinase-AKT, PLCgamma-PKC and STATs modules. May also activate the NF-kappa-B signaling cascade. Also directly phosphorylates other proteins like RGS16, activating its GTPase activity and probably coupling the EGF receptor signaling to the G protein-coupled receptor signaling. Also phosphorylates MUC1 and increases its interaction with SRC and CTNNB1/beta-catenin. [The UniProt Consortium]

Purity: Supernatant
Rabbit IgG SR: human
Immunogen: A synthetic phospho-peptide corresponding to residues surrounding Serine 1070 and 1071 of human EGF receptor.
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537 €

E3375-04D.100
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Receptor tyrosine kinase binding ligands of the EGF family and activating several signaling cascades to convert extracellular cues into appropriate cellular responses. Known ligands include EGF, TGFA/TGF-alpha, amphiregulin, epigen/EPGN, BTC/betacellulin, epiregulin/EREG and HBEGF/heparin-binding EGF. Ligand binding triggers receptor homo- and/or heterodimerization and autophosphorylation on key cytoplasmic residues. The phosphorylated receptor recruits adapter proteins like GRB2 which in turn activates complex downstream signaling cascades. Activates at least 4 major downstream signaling cascades including the RAS-RAF-MEK-ERK, PI3 kinase-AKT, PLCgamma-PKC and STATs modules. May also activate the NF-kappa-B signaling cascade. Also directly phosphorylates other proteins like RGS16, activating its GTPase activity and probably coupling the EGF receptor signaling to the G protein-coupled receptor signaling. Also phosphorylates MUC1 and increases its interaction with SRC and CTNNB1/beta-catenin. [The UniProt Consortium]

Purity: Supernatant
Rabbit IgG SR: human
Immunogen: A phospho specific peptide corresponding to residues surrounding threonine 678 of human EGFR.
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100 µl

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537 €

E3375-04E.100
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WB, IP, ICC Erklärungen der Abkürzungen ansehen.
Receptor tyrosine kinase binding ligands of the EGF family and activating several signaling cascades to convert extracellular cues into appropriate cellular responses. Known ligands include EGF, TGFA/TGF-alpha, amphiregulin, epigen/EPGN, BTC/betacellulin, epiregulin/EREG and HBEGF/heparin-binding EGF. Ligand binding triggers receptor homo- and/or heterodimerization and autophosphorylation on key cytoplasmic residues. The phosphorylated receptor recruits adapter proteins like GRB2 which in turn activates complex downstream signaling cascades. Activates at least 4 major downstream signaling cascades including the RAS-RAF-MEK-ERK, PI3 kinase-AKT, PLCgamma-PKC and STATs modules. May also activate the NF-kappa-B signaling cascade. Also directly phosphorylates other proteins like RGS16, activating its GTPase activity and probably coupling the EGF receptor signaling to the G protein-coupled receptor signaling. Also phosphorylates MUC1 and increases its interaction with SRC and CTNNB1/beta-catenin. [The UniProt Consortium]

Purity: Supernatant
Rabbit IgG SR: human
Immunogen: A phospho specific peptide corresponding to residues surrounding threonine 693 of human EGFR.
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537 €

E3375-04F.100
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WB, IP, ICC Erklärungen der Abkürzungen ansehen.
Receptor tyrosine kinase binding ligands of the EGF family and activating several signaling cascades to convert extracellular cues into appropriate cellular responses. Known ligands include EGF, TGFA/TGF-alpha, amphiregulin, epigen/EPGN, BTC/betacellulin, epiregulin/EREG and HBEGF/heparin-binding EGF. Ligand binding triggers receptor homo- and/or heterodimerization and autophosphorylation on key cytoplasmic residues. The phosphorylated receptor recruits adapter proteins like GRB2 which in turn activates complex downstream signaling cascades. Activates at least 4 major downstream signaling cascades including the RAS-RAF-MEK-ERK, PI3 kinase-AKT, PLCgamma-PKC and STATs modules. May also activate the NF-kappa-B signaling cascade. Also directly phosphorylates other proteins like RGS16, activating its GTPase activity and probably coupling the EGF receptor signaling to the G protein-coupled receptor signaling. Also phosphorylates MUC1 and increases its interaction with SRC and CTNNB1/beta-catenin. [The UniProt Consortium]

Purity: Supernatant
Rabbit IgG SR: human
Immunogen: A synthetic phospho-peptide corresponding to residues surrounding Tyrosine 1110 of human EGF receptor.
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537 €

E3375-04G.100
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Receptor tyrosine kinase binding ligands of the EGF family and activating several signaling cascades to convert extracellular cues into appropriate cellular responses. Known ligands include EGF, TGFA/TGF-alpha, amphiregulin, epigen/EPGN, BTC/betacellulin, epiregulin/EREG and HBEGF/heparin-binding EGF. Ligand binding triggers receptor homo- and/or heterodimerization and autophosphorylation on key cytoplasmic residues. The phosphorylated receptor recruits adapter proteins like GRB2 which in turn activates complex downstream signaling cascades. Activates at least 4 major downstream signaling cascades including the RAS-RAF-MEK-ERK, PI3 kinase-AKT, PLCgamma-PKC and STATs modules. May also activate the NF-kappa-B signaling cascade. Also directly phosphorylates other proteins like RGS16, activating its GTPase activity and probably coupling the EGF receptor signaling to the G protein-coupled receptor signaling. Also phosphorylates MUC1 and increases its interaction with SRC and CTNNB1/beta-catenin. [The UniProt Consortium]

Purity: Supernatant
Rabbit IgG SR: human
Immunogen: A phospho specific peptide corresponding to residues surrounding tyrosine 845 of human EGFR.
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100 µl

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537 €

E3375-04H.100
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WB, ICC Erklärungen der Abkürzungen ansehen.
Receptor tyrosine kinase binding ligands of the EGF family and activating several signaling cascades to convert extracellular cues into appropriate cellular responses. Known ligands include EGF, TGFA/TGF-alpha, amphiregulin, epigen/EPGN, BTC/betacellulin, epiregulin/EREG and HBEGF/heparin-binding EGF. Ligand binding triggers receptor homo- and/or heterodimerization and autophosphorylation on key cytoplasmic residues. The phosphorylated receptor recruits adapter proteins like GRB2 which in turn activates complex downstream signaling cascades. Activates at least 4 major downstream signaling cascades including the RAS-RAF-MEK-ERK, PI3 kinase-AKT, PLCgamma-PKC and STATs modules. May also activate the NF-kappa-B signaling cascade. Also directly phosphorylates other proteins like RGS16, activating its GTPase activity and probably coupling the EGF receptor signaling to the G protein-coupled receptor signaling. Also phosphorylates MUC1 and increases its interaction with SRC and CTNNB1/beta-catenin. [The UniProt Consortium]

Rabbit IgG SR: human
Immunogen: A synthetic peptide corresponding to residues surrounding Serine 695 in human EGFR.
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100 µl

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E3375-11A.100
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Receptor tyr