| 210 Treffer |
| ART-NR | PRODUKT | HERSTELLER | MENGE | PREIS |
| 321-COLP |
WB, IHC  Collagen is an extracellular matrix protein that serves as a scaffold defining the shape and mechanical properties of many tissues and organs including skin, tendon, artery walls, fibrocartilage, bone and teeth. Type 1 collagen is the most abundant protein in mammals. Collagens are synthesized with N-terminal and C-terminal propeptides that are cleaved during maturation and secretion. After cleavage of the propeptides, the most Nterminal and C-terminal remaining sequences are known as telopeptides. Mutations in the collagen 1, alpha 1 gene (COL1A1) are known to cause osteogenesis imperfecta (aka brittle bone disease) (Byers 1989). Furthermore, mutations found in the fist 90 residues of the helical region of alpha 1 collagen have been implicated in the prevention or delayed removal of the procollagen N-propeptide leading to a combined osteogenesis imperfecta and Ehlers-Danlos syndrome (EDS) phenotype (Cabral et al., 2005). MW: 180 kD Rabbit SR: rat, mouse, human Immunogen: synthetic peptide from the human collagen I alpha1 propeptide sequence |
PhosphoSolutions |
100 µl |
419 €
 |
| 322-COLT |
WB, IHC Collagen is an extracellular matrix protein that serves as a scaffold defining the shape and mechanical properties of many tissues and organs including skin, tendon, artery walls, fibrocartilage, bone and teeth. Type 1 collagen is the most abundant protein in mammals. Collagens are synthesized with N-terminal and C-terminal propeptides that are cleaved during maturation and secretion. After cleavage of the propeptides, the most Nterminal and C-terminal remaining sequences are known as telopeptides. Mutations in the collagen 1, alpha 1 gene (COL1A1) are known to cause osteogenesis imperfecta (aka brittle bone disease) (Byers 1989). Furthermore, mutations found in the fist 90 residues of the helical region of alpha 1 collagen have been implicated in the prevention or delayed removal of the procollagen N-propeptide leading to a combined osteogenesis imperfecta and Ehlers-Danlos syndrome (EDS) phenotype (Cabral et al., 2005). MW: 140 kD Rabbit SR: rat, mouse, human, sheep Immunogen: synthetic peptide from the human collagen I alpha1 telopeptide sequence |
PhosphoSolutions |
100 µl |
419 €
|
P120-3337 |
WB Beta-Catenin is thought to be regulated by the sequential phosphorylation of Ser29, Ser33, Ser37 and Thr41 by GSK3beta. Hyperphosphorylation promotes ubiquitylation and targeted destruction of beta-catenin. Rabbit IgG SR: human Immunogen: synthetic phosphopeptide corresponding to amino acid residues surrounding the phospho-Ser33,37 of human beta-Catenin |
PhosphoSolutions |
100 µl |
416 €
|
| P1205-80 |
WB, IHC MECP2 (Methyl-CpG Binding Protein 2) is a chromosomal protein that binds to methylated DNA. It can bind specifically to a single methyl-CpG pair and is not influenced by sequences flanking the methyl-CpGs. MECP2 has been shown to mediate transcriptional repression through interaction with histone deacetylase and the corepressor SIN3A. Defects in MECP2 are the cause of Rett syndrome (RTT). RTT is an X-linked dominant disease, it is a progressive neurologic developmental disorder and one of the most common causes of mental retardation in females. Recent studies have reported a new phosphorylation site at Ser80. Phosphorylation and dephosphorylation of this site may be involved in modulating the dynamic function of MECP2 in neurons transiting between resting and active states within neural circuits that underlie behaviors (Tao et al., 2009). MW: 75 kD Rabbit SR: rat, mouse, human Immunogen: synthetic phospho-peptide corresponding to amino acid residues surrounding the phospho-Ser80 of MECP2 (Methyl-CpG Binding Protein 2) protein |
PhosphoSolutions |
100 µl |
354 €
|
|
Cay13491-1 |
WB Rabbit IgG SR: human Immunogen: synthetic peptides corresponding to amino acids 1-5, 433-448 and 467-482 of human HDAC1 |
Cayman |
1 each |
254 €
|
| 2105-VIM |
WB, IF Vimentin is the major protein subunit of the 10nm or intermediate filaments (IFs) found in many kinds of mesenchymal and epithelial cells as well as developing neuronal and astrocytic precursor cells in the CNS. Vimentin is thought to be critically involved in lymphocyte adhesion and transmigration (Nieminen M et al. 2006). Copolymers are frequently formed between vimentin and other IFs, such as GFAP (in many kinds of astrocytes), desmin (in muscle cells) and neurofilament proteins (in developing neurons). Antibodies to vimentin are useful in studies of stem cells and generally to reveal the filamentous cytoskeleton. Recent studies suggest that vimentin affects prostate cancer cells motility and invasiveness (Zhao et al. 2008). MW: 50 kD Chicken SR: rat, mouse, human Immunogen: recombinant human Vimentin purified from E. coli |
PhosphoSolutions |
100 µl |
354 €
|
|
P1175-9 |
WB Specifically, GSK3beta has been shown to play a key inhibitory role in both the insulin and Wnt signaling pathways. It has been suggested that Ser9 phosphorylation underlies the inhibition of GSK3beta by insulin. Rabbit IgG SR: rat Immunogen: synthetic phosphopeptide corresponding to amino acid residues surrounding the phospho-Ser9 of GSK3beta |
PhosphoSolutions |
100 µl |
416 €
|
|
900-GLUR2 |
WB GluR1-4 belong to the class of AMPA receptors and play key roles in virtually all excitatory neurotransmission in the brain. Rabbit IgG SR: rat Immunogen: synthetic peptide corresponding to amino acid residues from rat GluR2 |
PhosphoSolutions |
100 µl |
416 €
|
| P1170-880 |
WB The ion channels activated by glutamate are typically divided into two classes. Those that are sensitive to N-methyl-D-aspartate (NMDA) are designated NMDA receptors (NMDAR) while those activated by alpha-amino-3-hydroxy-5-methyl-4-isoxalone propionic acid (AMPA) are known as AMPA receptors (AMPAR). The AMPAR are comprised of four distinct glutamate receptor subunits designated (GluR1-4) and they play key roles in virtually all excitatory neurotransmission in the brain (Keinänen et al., 1990, Hollmann and Heinemann, 1994). The number of GluR2 subunits in the AMPA receptor complex affects the Ca2 permeability, rectification and single-channel conductance of AMPA receptors. Ser880 has been identified as the PKC phosphorylation site within the C-terminal region of GluR2 and has been shown to differentially regulate the interaction of the PDZ domain-containing proteins GRIP1 and PICK 1 (Matsuda et al., 1999). MW: 100 kD Rabbit SR: rat, mouse, human, chicken, non-human primate, zebra fish Immunogen: synthetic phospho-peptide corresponding to amino acid residues surrounding the phospho-Ser880 of rat GluR2 |
PhosphoSolutions |
100 µl |
419 €
|
| 1120-MBP |
WB, IF Myelin Basic Protein (MBP) is one of the major proteins of the myelin sheath surrounding axons in the nervous system. Since it is of relatively low molecular weight and high abundance the protein sequence was determined from purified protein over 30 years ago (Eylar et al., 1971). The protein is made by oligodendrocytes in the central nervous system, so antibodies to MBP are good markers of this cell type. However, transcripts from the same gene are also expressed in certain hematopoetic lineage cells (Marty et al., 2002). In the central nervous system there are there different forms of the protein made by alternate transcription from a single gene, which have molecular weights of 21.5, 18.5, and 17.2 kDa. Since the two lower molecular weight forms are very close in molecular size, MBP antibodies typically show two bands on Western blots, one at about 22kDa and another at about 18kDa. Chicken IgY SR: rat, mouse, human, bovine Immunogen: three peptide sequences conserved in higher vertebrate MBP proteins |
PhosphoSolutions |
100 µl |
354 €
|
|
1240-TRB |
WB Thyroid hormones are essential for development of the central nervous system and exert their physiological role mainly through binding to specific nuclear receptors. Mouse IgG1 SR: human Immunogen: N-terminal peptide from the human thyroid hormone receptor, beta-isotope |
PhosphoSolutions |
100 µl |
416 €
|
| 1840-RHO |
WB, IHC Rhodopsin is a photoreceptor protein found in retinal rods. It is a complex formed by the binding of retinaldehyde, the oxidized form of retinol, to the protein opsin and undergoes a series of complex reactions in response to visible light resulting in the transmission of nerve impulses to the brain. Mutation of the rhodopsin gene is a major contributor to various retinopathies such as retinitis pigmentosa. The disease-causing protein generally aggregates with ubiquitin in inclusion bodies, disrupts the intermediate filament network and impairs the ability of the cell to degrade non-functioning proteins which leads to photoreceptor apoptosis (Berson et al., 1991). Other mutations on rhodopsin lead to X-linked congenital stationary night blindness, mainly due to constitutive activation, when the mutations occur around the chromophore binding pocket of rhodopsin (Dryja et al.,1993). Several other pathological states relating to rhodopsin have been discovered including poor post-Golgi trafficking, dysregulative activation, rod outer segment instability and arrestin binding. MW: 39 kD Mouse IgG1 SR: most mammals Immunogen: Bovine rhodopsin |
PhosphoSolutions |
100 µl |
419 €
|
|
1080-PSD95 |
WB PSD-95 is a very prominent component of the postsynaptic densities of synapses. Rabbit IgG SR: rat, mouse Immunogen: peptide corresponding to amino acid residues from the N-terminal region of rat PSD-95 |
PhosphoSolutions |
100 µl |
416 €
|
| 107-ASYN |
WB, IF Alpha-synuclein is a presynaptic neuronal protein that is thought to be involved in the formation of SNARE complexes. Most significantly, aggregated alpha-synuclein is one of the major components found in the Lewy bodies that occur in Parkinson's disease (PD) and other neurodegenerative disorders (Okochi et al., 2000). Early onset Parkinson's disease may be caused by a duplication or triplication of one of the alpha synuclein genes (Chartier- Harlin MC et al., 2004 and Singleton, AB et al., 2005). Alpha-synuclein is also found in the Lewy bodies of patients with diffuse Lewy body disease and inclusions in glial cells in the brains of patients with multiple system atrophy (MSA) and amyotrophic lateral sclerosis (ALS). MW: 15 kD Mouse IgG SR: human, rodent Immunogen: full length human alpha synuclein expressed in E. coli |
PhosphoSolutions |
100 µl |
354 €
|
| 2000-TDP |
WB, IHC TDP43 (Tar DNA Binding 43, TARDBP) was originally identified as a protein which binds to the 'transactivation response' (TAR) sequence found in the long terminal repeat of the HIV-1 virus genome (Ou et al.,1995). UV cross-linking of HeLa cell extract revealed a 43kDa protein which was cloned and sequenced and shown to contain two copies of the approx. 90 amino acid RRM domain. RRM is an acronym for RNA Recognition Motif, and this domain is found in many proteins which bind single stranded RNA and some which bind single stranded DNA. Northern blots showed that the protein is ubiquitous in tissue expression. Much interest has been focused on TDP43 recently due to its association with the inclusions seen in frontotemporal lobar degeneration and Amyotrophic Lateral Sclerosis (Neumann et al., 2006). The protein is present in these inclusions in partially degraded, hyperphosphorylated and ubiquitinated forms. MW: 43 kD Rabbit SR: rat, human Immunogen: synthetic peptide C-terminal to the caspase-cleavage site (between D219 and V220) of human TDP-43 |
PhosphoSolutions |
100 µl |
419 €
|
|
P180-386 |
WB Activated MEK 1 acts as a dual specificity kinase phosphorylating both a threonine and a tyrosine residue on MAP kinase. Rabbit IgG SR: rat Immunogen: Synthetic phosphopeptide corresponding to amino acid residues surrounding the pThr386 of human MEK 1 |
PhosphoSolutions |
100 µl |
416 €
|
| 2060-UCHL1 |
WB, IF Ubiquitin C-terminal hydrolase 1 (UCHL1) is also known as ubiquitin carboxyl esterase L1, ubiquitin thiolesterase, neuron-specific protein PGP9.5 and Park5. It was originally identified as a major component of the neuronal cytoplasm from 2-dimensional gel analysis of brain tissues, and was given the name PGP9.5. It was later found that ubiquitin C-terminal hydrolase enzyme activity was associated with the PGP9.5 protein. The ubiquitin C-terminal hydrolases cleave ubiquitin from other molecules. Regulation of the ubiquitin pathway is very important and many disease states are associated with defects in this pathway. Genetic knockout of UCHL1 in mice results in a motor neuron degeneration similar to the spontaneous gracile axonal dystrophy (gad) mutant mice. Point mutations in the UCHL1 gene are associated with some forms of human Parkinson's disease. Since UCHL1 is heavily expressed in neurons, it is released in large amounts following injury or degeneration, so the detection of UCHL1 in CSF and other bodily fluids can be used as a biomarker. MW: 24 kD Mouse IgG1 SR: rat, mouse, human, bovine Immunogen: recombinant full length human UCHL1 purified from E. coli |
PhosphoSolutions |
100 µl |
354 €
|
| 2061-UCHL1 |
WB, IF Ubiquitin C-terminal hydrolase 1 (UCHL1) is also known as ubiquitin carboxyl esterase L1, ubiquitin thiolesterase, neuron-specific protein PGP9.5 and Park5. It was originally identified as a major component of the neuronal cytoplasm from 2-dimensional gel analysis of brain tissues, and was given the name PGP9.5. It was later found that ubiquitin C-terminal hydrolase enzyme activity was associated with the PGP9.5 protein. The ubiquitin C-terminal hydrolases cleave ubiquitin from other molecules. Regulation of the ubiquitin pathway is very important and many disease states are associated with defects in this pathway. Genetic knockout of UCHL1 in mice results in a motor neuron degeneration similar to the spontaneous gracile axonal dystrophy (gad) mutant mice. Point mutations in the UCHL1 gene are associated with some forms of human Parkinson's disease. Since UCHL1 is heavily expressed in neurons, it is released in large amounts following injury or degeneration, so the detection of UCHL1 in CSF and other bodily fluids can be used as a biomarker. MW: 24 kD Chicken SR: rat, mouse, human, bovine Immunogen: recombinant full length human UCHL1 purified from E. coli |
PhosphoSolutions |
100 µl |
354 €
|
|
1330-RXRA |
WB Retinoic acid (RA, active metabolite of vitamine A) plays a prominent role in regulating the transcription of proliferating precursor cells to postmitotic differentiated cells. Mouse IgG1 SR: human Immunogen: N-terminal peptide from the human retinoic acid receptor, alpha isotype |
PhosphoSolutions |
100 µl |
416 €
|
| 2002-TR2 |
WB Testicular receptor 2 (TR2) is a member of the orphan nuclear receptor family. It is widely expressed at a low level throughout the adult testis. TR2 represses transcription and binds DNA directly interacting with HDAC3 and HDAC4 via DNA-binding domains (Franco et al., 2003). TR2 has also been implicated in regulation of estrogen receptor activity in mammary glands (Hun et al., 2002). In addition, TR2 has recently been shown to form a heterodimer with TR4 that can bind to the direct repeat 6 element of the hepatitis B virus (HBV) enhancer II region thus suppressing HBV gene expression (Lin et al., 2008). MW: 64 kD Rabbit SR: rat, mouse, human Immunogen: fusion protein from N-terminal peptide of mouse TR2 |
PhosphoSolutions |
100 µl |
354 €
|
|
144-APP |
WB A large body of evidence has implicated the amyloid precursor protein (APP) in the pathogenesis of Alzheimer?s disease (AD). Rabbit IgG SR: rat Immunogen: synthetic peptide corresponding to amino acid residues from the C-terminal region of rat APP |
PhosphoSolutions |
100 µl |
416 €
|
| 895-GLUR1 |
WB The ion channels activated by glutamate are typically divided into two classes. Those that are sensitive to N-methyl-D-aspartate (NMDA) are designated NMDA receptors (NMDAR) while those activated by a-amino-3-hydroxy-5-methyl-4-isoxalone propionic acid (AMPA) are known as AMPA receptors (AMPAR). The AMPAR are comprised of four distinct glutamate receptor subunits designated (GluR1-4) and they play key roles in virtually all excitatory neurotransmission in the brain (Keinänen et al., 1990, Hollmann and Heinemann, 1994). MW: 100 kD Mouse IgG SR: rat, mouse Immunogen: synthetic peptide corresponding to amino acid residues from the N-terminal region of rat GluR1 |
PhosphoSolutions |
100 µl |
419 €
|
| 592-FRAC |
WB, IHC Fractin (fragment of actin) is a caspase-specific cleavage product of actin and serves as a novel marker of apoptosis-related events. The antibody has been shown to detect the processes and cell bodies of degenerating neurons and plaque-associated microglia in Alzheimer's disease (Yang et al., 1998). It has recently been reported that Fractin may have a functional role in apoptotic signaling in oligodendrocytes (Schulz, R., et al., Glia, 2009, in press). MW: 32 kD Rabbit SR: rat, human Immunogen: synthetic peptide taken from the C terminus of the 32-kDa actin fragment |
PhosphoSolutions |
100 µl |
354 €
|
|
431-DATC |
WB, IHC DAT antibodies are widely used as markers for dopaminergic and noradrenergic neurons in a variety of applications. Rabbit IgG SR: mouse, human, monkey Immunogen: Synthetic peptide from the Intracellular C-terminus region of Human Dopamine Transporter (DAT) |
PhosphoSolutions |
100 µl |
416 €
|
|
434-DATEL2 |
WB, IHC DAT antibodies are widely used as markers for dopaminergic and noradrenergic neurons in a variety of applications. Rabbit IgG SR: human, monkey Immunogen: Synthetic peptide from the Extracellular Loop 2 (EL2) region of human Dopamine Transporter |
PhosphoSolutions |
100 µl |
416 €
|
|
P115-4908 |
WB, IHC ATF2 has been implicated in the transcriptional regulation of a number of genes including cytokines, cell cycle control and apoptosis. Serine 490 and serine 498 are novel phosphorylation sites on ATF that have recently been identified. Rabbit IgG SR: human Immunogen: synthetic phosphopeptide corresponding to amino acid residues surrounding the phospho-Ser490,498 of human ATF2 |
PhosphoSolutions |
100 µl |
416 €
|
|
1504-N1 |
WB, IF, IHC The NMDAR plays an essential role in memory, neuronal development and it has also been implicated in several disorders of the central nervous system. Rabbit IgG SR: rat Immunogen: Synthetic peptide from the NR1-subunit, N1 Splice Variant Insert of rat NMDA Receptor |
PhosphoSolutions |
25 µg |
416 €
|
|
1505-C1 |
WB, IF, IHC The NMDAR plays an essential role in memory, neuronal development and it has also been implicated in several disorders of the central nervous system. Rabbit IgG SR: rat Immunogen: Synthetic peptide from the NR1-subunit, C1 Splice Variant Insert of the NMDA Receptor |
PhosphoSolutions |
25 µg |
416 €
|
|
1506-C2 |
WB, IF, IHC Considerable attention has been focused on the distribution and expression of these splice variants that may affect the functional properties and regulation of the NMDAR Rabbit IgG SR: rat Immunogen: Synthetic peptide from the NR1-subunit, C2 Splice Variant Insert of rat NMDA Receptor |
PhosphoSolutions |
25 µg |
416 €
|
|
1507-C2' |
WB, IF, IHC Considerable attention has been focused on the distribution and expression of these splice variants that may affect the functional properties and regulation of the NMDAR. Rabbit IgG SR: rat Immunogen: Synthetic peptide from the NR1-subunit, C2? Splice Variant Insert of rat NMDA Receptor |
PhosphoSolutions |
25 µg |
416 €
|
|
1508-NR1 |
WB, IP The NMDAR plays an essential role in memory, neuronal development and it has also been implicated in several disorders of the central nervous system. Mouse IgG SR: rat, human, mouse Immunogen: Fusion protein containing amino acids 1-564 of the NR1-subunit of rat NMDA Receptor |
PhosphoSolutions |
15 µg |
416 €
|
| 1452-NFL |
WB, IF Neurofilaments are the 10nm or intermediate filament proteins found specifically in neurons, and are composed predominantly of three major proteins called NF-L, NF-M and NF-H. NF-L is the neurofilament light or low molecular weight polypeptide and runs on SDS-PAGE gels at about 68kDa. Antibodies to NF-L are useful for identifying neuronal cells and their processes in tissue sections and in tissue culture. Mutations in the protein coding region of the human NF-L gene cause some forms of Charcot-Marie-Tooth disease. MW: 68 kD Mouse IgG1 SR: rat, mouse, human, bovine, chicken Immunogen: preparation of porcine intermediate filaments |
PhosphoSolutions |
100 µl |
354 €
|
| 1453-NFL |
WB, IF Neurofilaments are the 10nm or intermediate filament proteins found specifically in neurons, and are composed predominantly of three major proteins called NF-L, NF-M and NF-H. NF-L is the neurofilament light or low molecular weight polypeptide and runs on SDS-PAGE gels at about 68kDa. Antibodies to NF-L are useful for identifying neuronal cells and their processes in tissue sections and in tissue culture. Mutations in the protein coding region of the human NF-L gene cause some forms of Charcot-Marie-Tooth disease. MW: 68 kD Chicken IgY SR: rat, mouse, human, bovine, chicken Immunogen: preparation of bovine spinal cord intermediate filaments |
PhosphoSolutions |
100 µl |
354 €
|
|
1210-TRA |
WB Thyroid hormones are essential for development of the central nervous system and exert their physiological role mainly through binding to specific nuclear receptors. Mouse IgG1 SR: human Immunogen: N-terminal peptide from the human thyroid hormone receptor, alpha1/alpha2-isotope |
PhosphoSolutions |
100 µl |
416 €
|
|
1220-TRA |
WB Thyroid hormones are essential for development of the central nervous system and exert their physiological role mainly through binding to specific nuclear receptors. Mouse IgG2a SR: human Immunogen: N-terminal peptide from the human thyroid hormone receptor, alpha1/alpha2-isotope |
PhosphoSolutions |
100 µl |
416 €
|
|
1230-TRA2 |
WB Thyroid hormones are essential for development of the central nervous system and exert their physiological role mainly through binding to specific nuclear receptors. Mouse IgG1 SR: human Immunogen: N-terminal peptide from the human thyroid hormone receptor, alpha2-isotope |
PhosphoSolutions |
100 µl |
416 €
|
|
1905-SNAP |
WB Decreased levels of SNAP25 have been found in the brains of patients with Down Syndrome and Alzheimer?s disease Rabbit IgG SR: rat Immunogen: synthetic peptide corresponding to amino acid residues from the C-terminal region of rat SNAP25 |
PhosphoSolutions |
100 µl |
416 €
|
| 319-COBRA |
WB COBRA1 (cofactor of BRCA1) also known as NELF-B, is an essential component of the negative elongation factor (NELF) complex. COBRA1 has been shown to directly bind estrogen receptor alpha (ERa) and repress ERa-mediated transcription (Aiyar SE et al., 2004). COBRA1 has also been demonstrated to interact with c-Jun and c-Fos suggesting a role in modulation of the AP-1 pathway and therefore may be important in cell proliferation, differentiation, apoptosis and oncogenesis (Zhong H et al., 2004). MW: 62 kD Mouse IgG1 SR: rat, mouse, human Immunogen: recombinant full length human COBRA1 purified from E. coli |
PhosphoSolutions |
100 µl |
419 €
|
|
1310-RXRG |
WB Retinoic acid (RA, active metabolite of vitamine A) plays a prominent role in regulating the transcription of proliferating precursor cells to postmitotic differentiated cells. Mouse IgG1 SR: human Immunogen: Hinge peptide from the human retinoid x receptor, gamma isotype |
PhosphoSolutions |
100 µl |
416 €
|
|
327-CON |
WB Connexin 43 forms gap-junctional channels and regulates the permeability of these gap junctions to small molecules. Rabbit IgG SR: rat Immunogen: synthetic peptide corresponding to amino acid residues from the C-terminal region of rat connexin43 |
PhosphoSolutions |
100 µl |
416 €
|
|
P1007-368 |
WB Phosphorylation of Ser368 by PKC induces a conformational change of connexin43 that results in a decrease in gap junction permeability. Rabbit IgG SR: rat Immunogen: synthetic phosphopeptide corresponding to amino acid residues surrounding the phospho-Ser368 of rat Connexin43 |
PhosphoSolutions |
100 µl |
416 €
|
| 1520-NSE |
WB, IF Neuron specific enolase (NSE) is an enzyme which catalyzes the conversion of 2-phosphoglycerate to phosphoenolpyruvate in the glycolytic pathway, and also the reverse reaction in gluconeogenesis. It is one of three mammalian enolases, which are also known as ENO1, ENO2, and ENO3 or alternately as enolase alpha, beta and gamma. The three enolases have different cell type specific expression patterns, so that antibodies to them are useful cell type specific markers (MacAlesse et al., 1988). NSE corresponds to ENO2 or enolase gamma and is heavily expressed in neuronal cells. ENO1 is also known as enolase alpha and as non-neuronal enolase. The third enolase, ENO3 or enolase beta, is expressed in muscle cells. Since neurons require a great deal of energy, they are very rich in glycolytic enzymes such a GAPDH and NSE. Antibodies to this protein are therefore useful to identify neuronal cell bodies, developing neuronal lineage and neuroendocrine cells. Release of NSE from damaged neurons into CSF and blood has also been used as a biomarker of neuronal injury. MW: 47 kD Rabbit SR: rat, human Immunogen: recombinant human NSE expressed in and purified from E. coli |
PhosphoSolutions |
100 µl |
354 €
|
|
1320-RXRB |
WB Retinoic acid (RA, active metabolite of vitamine A) plays a prominent role in regulating the transcription of proliferating precursor cells to postmitotic differentiated cells. Mouse IgG1 SR: human Immunogen: Hinge peptide from the human retinoid x receptor, beta isotype |
PhosphoSolutions |
100 µl |
416 €
|
|
1340-RXRB |
WB Retinoic acid (RA, active metabolite of vitamine A) plays a prominent role in regulating the transcription of proliferating precursor cells to postmitotic differentiated cells. Mouse IgG1 SR: human Immunogen: N-terminal peptide from the human retinoid x receptor, beta isotype |
PhosphoSolutions |
100 µl |
416 €
|
|
418-DDCH |
WB DDC antibodies can be used as markers for dopaminergic, noradrenergic and serotonergic neurons in a variety of applications. Rabbit IgG SR: rat, human, bovine, swine, dog, guinea pig Immunogen: Synthetic peptide from N-terminus region of human DOPA Decarboxylase (DDC) |
PhosphoSolutions |
100 µl |
416 €
|
|
1497-NR2A |
WB NMDA receptor subtype of glutamate-gated ion channels possesses high calcium permeability and voltage-dependent sensitivity to magnesium. Activation requires binding of agonist to both types of subunits. Rabbit Ig SR: human, mouse, rat Immunogen: Fusion protein from the C-terminus region of the NR2A-subunit of rat NMDA Receptor |
PhosphoSolutions |
50 µl |
352 €
|
|
1500-NR2A |
WB The NMDAR plays an essential role in memory, neuronal development and it has also been implicated in several disorders of the central nervous system. Rabbit IgG SR: rat, human Immunogen: Fusion protein from the C-terminus of the NR2A-subunit of rat NMDA Receptor |
PhosphoSolutions |
10 µg |
416 €
|
| 1501-NR2A |
WB, IHC The ion channels activated by glutamate are typically divided into two classes. Glutamate receptors that are activated by kainate and a-amino-3-hydroxy-5-methyl-4-isoxalone propionic acid (AMPA) are known as kainate/AMPA receptors (K/AMPAR). Those that are sensitive to N-methyl-D-aspartate (NMDA) are designated NMDA receptors (NMDAR). The NMDAR plays an essential role in memory, neuronal development and it has also been implicated in several disorders of the central nervous system including Alzheimer's, epilepsy and ischemic neuronal cell death (Grosshans et al., 2002, Wenthold et al., 2003, Carroll and Zukin, 2002). The NMDA receptor is also one of the principal molecular targets for alcohol in the CNS (Lovinger et al., 1989, Alvestad et al., 2003, Snell et al., 1996). The NMDAR is also potentiated by protein phosphorylation (Lu et al., 1999). The rat NMDAR1 (NR1) was the first subunit of the NMDAR to be cloned. The NR1 protein can form NMDA activated channels when expressed in Xenopus oocytes but the currents in such channels are much smaller than those seen in situ. Channels with more physiological characteristics are produced when the NR1 subunit is combined with one or more of the NMDAR2 (NR2 A-D) subunits. MW: 180 kD Rabbit SR: rat, mouse, bovine, canine Immunogen: synthetic peptide from the N-terminus of the NR2A subunit of rat NMDA receptor |
PhosphoSolutions |
100 µl |
419 €
|
| P1514-1325 |
WB The ion channels activated by glutamate that are sensitive to N-methyl-D-aspartate (NMDA) are designated NMDA receptors (NMDAR). The NMDAR plays an essential role in memory, neuronal development and it has also been implicated in several disorders of the central nervous system including Alzheimer's, epilepsy and ischemic neuronal cell death (Grosshans et al., 2002, Wenthold et al., 2003, Carroll and Zukin, 2002). The NMDA receptor is also one of the principal molecular targets for alcohol in the CNS (Lovinger et al., 1989, Alvestad et al., 2003, Snell et al., 1996). Channels with physiological characteristics are produced when the NR1 subunit is combined with one or more of the NMDAR2 (NR2 A-D) subunits (Ishii et al., 1993). Recently, phosphorylation of Tyrosine 1325 of the NR2A subunit has been shown to be increased in human brain tissue sections from HIV-infected individuals with encephalitis (King et al., 2010). In addition, Tyr1325 phosphorylation has been linked with depression-related behavior (Taniguchi et al., 2009). MW: 180 kD Rabbit SR: rat, mouse, bovine, canine Immunogen: synthetic phospho-peptide corresponding to amino acid residues surrounding the phospho-Tyr1325 of NMDA NR2A |
PhosphoSolutions |
100 µl |
419 €
|
| 1990-STX |
WB, IHC Syntaxins are a family of proteins involved in the docking of synaptic vesicles with the plasma membrane. Syntaxin, along with synaptobrevin and SNAP-25, forms the SNARE complex which mediates synaptic vesicle fusion and exocytosis. Binding of Munc18-1 to the N-terminus of syntaxin 1 has been demonstrated to be essential for exocytic membrane fusion (Khvotchev et al., 2007). Decreased levels of phosphorylated syntaxin 1 in the prefrontal cortex have recently been correlated with schizophrenia (Castillo et al., 2010). MW: 36 kD Mouse IgG1 SR: rat, human, porcine Immunogen: synaptic immunoprecipitate (crude) from human brain |
PhosphoSolutions |
100 µl |
419 €
|
| 1100-MAP2 |
WB, IF Microtubules are 25nm diameter protein rods found in most kinds of eukaryotic cells. They are polymerized from a dimeric subunit made of one alpha subunit and one beta tubulin subunit. Microtubules are associated with a family of proteins called microtubule associated proteins (MAPs), which includes the protein t (tau) and a group of proteins referred to as MAP1, MAP2, MAP3, MAP4 and MAP5 (Kindler & Gardner 1994). MAP2 is made up of two approx. 280kDa apparent molecular weight bands referred to as MAP2a and MAP2b. A third lower molecular weight form, usually called MAP2c, corresponds to a pair of protein bands running at approx. 70kDa on SDS-PAGE gels. All these MAP2 forms are derived from a single gene by alternate transcription, and all share a C-terminal sequence which includes either three or four microtubule binding peptide sequences, which are very similar to those found in the related microtubule binding protein t (tau). MAP2 isoforms are expressed only in neuronal cells and specifically in the perikarya and dendrites of these cells. MAP2 has been recently shown to be the specific receptor for the neurosteroid pregnenolone (Fontaine-Lenore V. et al., 2006). MW: 280 kD Chicken IgY SR: bovine, human, mouse, rat Immunogen: bovine MAP2 isolated from brain by the GTP microtubule cycling method |
PhosphoSolutions |
100 µl |
354 €
|
|
P1150-41 |
WB Gap-43 is thought to have an important role in development and plasticity. Rabbit IgG SR: rat, mouse, human Immunogen: Synthetic phosphopeptide corresponding to amino acid residues surrounding the pSer41 of Gap-43 |
PhosphoSolutions |
100 µl |
416 €
|
|
420-DBHC |
WB DBH catalyzes the conversion of dopamine to norepinephrine and serves as a marker of noradrenergic cells. Sheep IgG SR: mouse, human, monkey Immunogen: Synthetic peptide from the C-terminus region of human Dopamine &-Hydroxylase (DBH) |
PhosphoSolutions |
100 µl |
416 €
|
|
423-DBHN |
WB DBH catalyzes the conversion of dopamine to norepinephrine and serves as a marker of noradrenergic cells. Sheep IgG SR: human, monkey Immunogen: Synthetic peptide from the N-terminus region of human Dopamine-Hydroxylase (DBH) |
PhosphoSolutions |
100 µl |
416 €
|
|
1975-STG |
WB Synaptotagmin 1 is a synaptic vesicle membrane glycoprotein that is widely expressed throughout the CNS and is generally thought to act as the Ca2+ sensor in the regulation of exocytosis and neurotransmitter release. Rabbit IgG SR: rat Immunogen: synthetic peptide corresponding to amino acid residues within the synaptotagmin I protein |
PhosphoSolutions |
100 µl |
416 €
|
| 315-CHAT |
WB, IHC Choline acetyltransferase is a neuronal enzyme which catalyzes the reaction between Acetyl CoA and choline resulting in the formation of acetylcholine. It is therefore found primarily in cholinergic neurons making it a valuable marker for diseases associated with decreased cholinergic function such as Schizophrenia, Alzheimer disease (AD) and Down syndrome (Holt et al. 1999). Decreased choline acetyltransferase activity in particular has been shown in Schizophrenic subjects (Karson et al 1993). It has furthermore been demonstrated that in patients with AD, there are significantly lower levels of cortical ChAT that correlate with severity of the disease as measured by loss of neuropsychological function (Baskin et al. 1999). MW: 70 kD Goat SR: rat, mouse, human, chicken, non-human primate, guinea pig Immunogen: native choline acetyltransferase purified from human placenta |
PhosphoSolutions |
100 µl |
419 €
|
| 316-CHAT |
WB, IHC Choline acetyltransferase is a neuronal enzyme which catalyzes the reaction between Acetyl CoA and choline resulting in the formation of acetylcholine. It is therefore found primarily in cholinergic neurons making it a valuable marker for diseases associated with decreased cholinergic function such as Schizophrenia, Alzheimer disease (AD) and Down syndrome (Holt et al. 1999). Decreased choline acetyltransferase activity in particular has been shown in Schizophrenic subjects (Karson et al 1993). It has furthermore been demonstrated that in patients with AD, there are significantly lower levels of cortical ChAT that correlate with severity of the disease as measured by loss of neuropsychological function (Baskin et al. 1999). MW: 70 kD Rabbit SR: rat, mouse, human, chicken, non-human primate, guinea pig Immunogen: native choline acetyltransferase purified from human placenta |
PhosphoSolutions |
100 µl |
354 €
|
| 2004-TR4 |
WB Testicular receptor 4 (TR4) is a member of the orphan nuclear receptor superfamily. Data suggests that TR4 may function as a regulator that modulates many signaling pathways. It has been suggested that TR4 is required for normal cerebellar development as TR4 knockout mice exhibit behavioral deficits in motor coordination (Chen, YT et al.,2008) and plays important roles in growth, embryonic and early postnatal survival (Collins, LL, et al., 2004). MW: 64 kD Rabbit SR: rat, mouse, human Immunogen: fusion protein of N-terminal peptide from mouse TR4 |
PhosphoSolutions |
100 µl |
354 €
|
|
480-DYN |
WB Dynamin is a member of a group of nerve terminal proteins called dephosphins that regulate synaptic vesicle endocytosis. Rabbit IgG SR: rat Immunogen: synthetic peptide corresponding to amino acid residues from the N-terminal region of human Dynamin |
PhosphoSolutions |
100 µl |
416 €
|
|
P1050-774 |
WB, IF, IHC Phosphorylation at Ser774 and Ser778 on dynamin is thought to play a key role in synaptic vesicle trafficking. Sheep IgG SR: rat, mouse, human Immunogen: Synthetic phosphopeptide corresponding to amino acid residues surrounding the pSer774 of Dynamin |
PhosphoSolutions |
100 µl |
416 €
|
|
P1050-778 |
WB Phosphorylation at Ser774 and Ser778 on dynamin is thought to play a key role in synaptic vesicle trafficking. Sheep IgG SR: rat, mouse, human Immunogen: Synthetic phosphopeptide corresponding to amino acid residues surrounding the pSer778 of Dynamin |
PhosphoSolutions |
100 µl |
416 €
|
| 597-FTO |
WB, IF The FTO gene is the most robust gene for common obesity characterized to date. FTO gene expression has been found to be significantly upregulated in the hypothalamus of rats after food deprivation and strongly negatively correlated with the expression of orexin peptide which is involved in the stimulation of food intake (Fredricksson R et al., 2008). Deletion analysis of FTO gene in mice showed that Fto is functionally involved in the control of both energy intake and energy expenditure (Fischer J et al., 2009). MW: 58 kD Mouse IgG SR: rat, mouse, human Immunogen: synthetic peptide from Fto |
PhosphoSolutions |
100 µl |
419 €
|
|
P1148-923 |
WB Phosphorylation of Ser923 is thought to be important in the regulation of GABAB receptor function. Rabbit IgG SR: rat Immunogen: synthetic phosphopeptide corresponding to amino acid residues surrounding the phospho-Ser923 of GABA B R1 |
PhosphoSolutions |
100 µl |
416 €
|
| 600-GAPDH |
WB, IF Glyceraldehyde 3-Phosphate Dehydrogenase (GAPDH) is a metabolic enzyme responsible for catalyzing one step in the glycolytic pathway, the reversible oxidative phosphorylation of glyceraldehyde 3-phosphate. Because GAPDH is a protein expressed in large amounts and which is required at all times for important 'house keeping' functions, levels of GAPDH mRNA are often measured and used as standards in studies of mRNA expression. Increasingly, scientists are making use of specific antibodies to GAPDH in comparable studies of levels of protein expression. This antibody can be used as a loading control for western blotting experiments, allowing comparison between the level of this protein and others in a cell or tissue. Apart from a role in glycolysis, GAPDH may have other roles such as in the activation of transcription. GAPDH is reported to bind to a variety of other proteins, including the amyloid precursor protein, mutations in which cause some forms of Alzheimer's disease, and the polyglutamine tracts of Huntingtin, the protein product aberrant forms of which are causative of Huntington's disease. Associations with actin and tubulin have also been reported. The protein may also have a role in the regulation of apoptosis, and interestingly migrates from the cytoplasm into the nucleus when cells become apoptotic. MW: 38 kD Mouse IgM SR: rat, mouse, human, bovine, chicken, porcine Immunogen: extensively purified pig GAPDH |
PhosphoSolutions |
100 µl |
354 €
|
| 560-FIB |
WB, IF Nop1p was originally identified as a nucleolar protein of bakers yeast, Saccharomyces cerevisiae. The Nop1p protein is 327 amino acids in size (34.5kDa), is essential for yeast viability, and is localized in the nucleoli. The systematic name for S. cerevisiae Nop1 is YDL014W, and it is now known to be part of the small subunit processome complex, involved in the processing of pre-18S ribosomal RNA. Nop1p is the yeast homologue of a protein found in all eukaryotes and archea generally called fibrillarin. Fibrillarin/Nop1p is extraordinarily conserved, so that the yeast and human proteins are 67% identical, and the human protein can functionally replace the yeast protein. Patients with the autoimmune disease scleroderma often have strong circulating autoantibodies to an approx. 34kDa protein which was subsequently found to be fibrillarin. Recent studies show that knock-out of the fibrillarin gene in mice results in embryonic lethality, although mice with only one functional fibrillarin/Nop1p gene were viable. This antibody is becoming widely used as a convenient marker for nucleoli in a wide variety of species. MW: 34 kD Mouse IgG1 SR: rat, human, drosophila, some invertebrates Immunogen: Yeast nuclear preparations |
PhosphoSolutions |
100 µl |
354 €
|
| P1573-416 |
WB Tau is a key microtubule-associated protein that plays an important role in the formation of microtubules in axons (Binder et al. 1985). Six tau isoforms have been identified as products of a single gene produced by alternative mRNA splicing (Goedert 1990). Tau mutations have been implicated in many neurodegenerative disorders such as Alzheimer's disease (AD), Pick's disease and progressive supranuclear palsy. It has been well documented that hyperphosphorylated tau is a major component of paired helical filaments in AD brain (Lee 1995). Serine 416 has been demonstrated to be a major phosphorylation site in vitro by CaM kinase II (Steiner at al. 1990). Rabbit SR: rat, mouse, human, bovine, non-human primate, canine Immunogen: synthetic phospho-peptide corresponding to amino acid residues surrounding the phospho-Ser416 of rat tau |
PhosphoSolutions |
100 µl |
419 €
|
| 1600-PEBP |
WB Phosphatidylethanolamine binding protein (PEBP), also known as Raf kinase inhibitory protein (RKIP) is a highly conserved multifunctional protein that modulates the Raf/MAPK signaling cascade and has been implicated as a suppressor of metastatic cancer (Trakul N et al., 2005). PEBP has been shown to not only inhibit cell proliferation but also to induce differentiation of human keratinocytes (Yamazaki et al., 2004). Dysregulation of calpain activity results in cellular degeneration in conditions such as Alzheimer's disease and recently PEBP has been identified as a potential in vivo calpain substrate (Chen at al., 2006). MW: 22 kD Rabbit SR: rat Immunogen: native PEBP protein purified from rat |
PhosphoSolutions |
100 µl |
354 €
|
|
P1160-831 |
WB GluR1 is potentiated by phosphorylation at Ser831 which has been shown to be mediated by either PKC or CaM kinase II. Rabbit IgG SR: rat, mouse, human Immunogen: Synthetic phosphopeptide corresponding to amino acid residues surrounding the pSer831 of GluR1 |
PhosphoSolutions |
150 µl |
416 €
|
|
P1160-845 |
WB, IF, IHC The GluR1 subunit is widely expressed throughout the nervous system. Rabbit IgG SR: rat, mouse, human Immunogen: Synthetic phosphopeptide corresponding to amino acid residues surrounding the pSer845 of GluR1 |
PhosphoSolutions |
150 µl |
416 €
|
|
1498-NR2B |
WB NMDA receptor subtype of glutamate-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Mediated by glycine. Rabbit Ig SR: human, mouse, rat Immunogen: Fusion protein from the C-terminus region of the NR2B-subunit of rat NMDA Receptor |
PhosphoSolutions |
50 µl |
352 €
|
|
1499-NR2B |
WB, IP, IHC ( frozen ) The NMDAR plays an essential role in memory, neuronal development and it has also been implicated in several disorders of the central nervous system. Rabbit IgG SR: rat, human Immunogen: Fusion protein from the C-terminus of the NR2B-subunit of rat NMDA Receptor |
PhosphoSolutions |
10 µg |
416 €
|
| 1503-NR2B |
WB, IHC The ion channels activated by glutamate that are sensitive to N-methyl-D-aspartate (NMDA) are designated NMDA receptors (NMDAR). The NMDAR plays an essential role in memory, neuronal development and it has also been implicated in several disorders of the central nervous system including Alzheimer's, epilepsy and ischemic neuronal cell death (Grosshans et al., 2002, Wenthold et al., 2003, Carroll and Zukin, 2002). The NMDA receptor is also one of the principal molecular targets for alcohol in the CNS (Lovinger et al., 1989, Alvestad et al., 2003, Snell et al., 1996). The rat NMDAR1 (NR1) was the first subunit of the NMDAR to be clonedand it can form NMDA activated channels when expressed in Xenopus oocytes but the currents in such channels are much smaller than those seen in situ. Channels with more physiological characteristics are produced when the NR1 subunit is combined with one or more of the NMDAR2 (NR2 A-D) subunits. Overexpression of the NR2B-subunit of the NMDA receptor has been associated with increases in learning and memory while aged, memory impaired animals have deficiencies in NR2B expression (Clayton et al., 2002a, Clayton et al., 2002b). The NMDAR is also potentiated by protein phosphorylation (Lu et al., 1999). MW: 180 kD Rabbit SR: rat, mouse, human, bovine, chicken, non-human primate, canine Immunogen: synthetic peptide from the N-terminus of the NR2B subunit of rat NMDA receptor |
PhosphoSolutions |
100 µl |
419 €
|
|
P1516-1252 |
WB Phosphorylation of Tyr1252 in NR2B is thought to potentiate NMDA receptor-dependent influx of calcium. Rabbit IgG SR: rat Immunogen: synthetic phosphopeptide corresponding to amino acid residues surrounding the phospho-Tyr1252 of the rat NMDA receptor |
PhosphoSolutions |
100 µl |
416 €
|
|
P1516-1336 |
WB Phosphorylation of Tyr1336 in NR2B is thought to potentiate NMDA receptor-dependent influx of calcium. Rabbit IgG SR: rat Immunogen: synthetic phosphopeptide corresponding to amino acid residues surrounding the phospho-Tyr1336 of the rat NMDA receptor |
PhosphoSolutions |
100 µl |
416 €
|
|
P1516-1472 |
WB The NMDAR plays an essential role in memory, neuronal development and it has also been implicated in several disorders of the central nervous system. Rabbit IgG SR: rat, mouse, human Immunogen: Synthetic phosphopeptide corresponding to amino acid residues surrounding the anti-pTyr1472 of NMDA Receptor NR2B |
PhosphoSolutions |
100 µl |
416 €
|
|
P1516-1480 |
WB It has been shown that phosphorylation of Ser1480 disrupts the interaction of NR2B with the PDZ domains of PSD-95 and SAP102 and decreases surface NR2B expression in neurons. Rabbit IgG SR: rat Immunogen: synthetic phosphopeptide corresponding to amino acid residues surrounding the phospho-Ser1480 of the NR2B subunit of the rat NMDA receptor |
PhosphoSolutions |
100 µl |
416 €
|
| 1538-OLIG2 |
WB, IHC, IP Olig2 is a transcription factor which is required for oligodendrocyte and motor neuron specification in the spinal cord, as well as for the development of somatic motor neurons in the hindbrain. Expressed in the ventral spinal cord as early as 9.5 dpc and scattered in the mantle zone, likely corresponding to oligodendrocyte progenitors migrating out from their site of origin. (Arnett et al., 2004) From 10.5 through 14.5 dpc, Olig2 is expressed in numerous cells in the ventricular and subventricular zones of the lateral and medial ganglionic eminences, suggesting that expression might not be limited to the oligodendrocytic lineage. Olig2 has further been shown to be critical in the proliferation of malignant glioma in brain tumors (Ligon et al., 2007). MW: 27 kD Rabbit IgG SR: rat, mouse, human Immunogen: recombinant mouse Olig2 |
PhosphoSolutions |
100 µl |
419 €
|
| 1450-NFH |
WB, IF Neurofilaments are the 10nm or intermediate filament proteins found specifically in neurons, and are composed predominantly of three major proteins called NF-L, NF-M and NF-H. NF-H is the neurofilament high or heavy molecular weight polypeptide and runs on SDS-PAGE gels at 200-220 kDa, with some variability across species boundaries. Antibodies to NF-H are useful for identifying neuronal cells and their processes in tissue sections and in tissue culture. NF-H antibodies can also be useful to visualize neurofilament accumulations seen in many neurological diseases, such as Amyotrophic Lateral Sclerosis (Lou Gehrig's disease) and Alzheimer's disease. MW: 200 kD Mouse IgG1 SR: chicken, most mammals Immunogen: purified bovine NF-H |
PhosphoSolutions |
100 µl |
354 €
|
| 1451-NFH |
WB, IF Neurofilaments are the 10nm or intermediate filament proteins found specifically in neurons, and are composed predominantly of three major proteins called NF-L, NF-M and NF-H. NF-H is the neurofilament high or heavy molecular weight polypeptide and runs on SDS-PAGE gels at 200-220 kDa, with some variability across species boundaries. Antibodies to NF-H are useful for identifying neuronal cells and their processes in tissue sections and in tissue culture. NF-H antibodies can also be useful to visualize neurofilament accumulations seen in many neurological diseases, such as Amyotrophic Lateral Sclerosis (Lou Gehrig's disease) and Alzheimer's disease. MW: 200 kD Chicken IgY SR: rat, mouse, human, chicken Immunogen: purified bovine NF-H |
PhosphoSolutions |
100 µl |
354 €
|
| 1630-PER |
WB, IF Peripherin is an approx. 57kDa intermediate filament subunit found initially in sensory neurons of the peripheral nervous systems, which gives the protein its name. Subsequently, peripherin was found in some sensory and other neurons of the central nervous system and also in PC12 cells. Peripherin is also expressed in certain neuroendocrine tumors and in the insulin producing cells of the pancreas. Peripherin belongs to the Class III family of intermediate filament subunits which also includes vimentin, glial fibrillary acidic protein (GFAP) and desmin. In contrast to the neurofilaments, peripherin is strongly up-regulated after nerve injury. Antibodies to peripherin can be used in identifying, classifying, and studying neurons throughout the nervous system. Peripherin is also a good diagnostic marker for ballooned axons seen in Lou Gehrig's disease (Amyotrophic lateral sclerosis) and some neuronally derived tumors. Autoantibodies to peripherin are frequently seen in the sera of patients with diabetes. Peripherin is not related to peripherin/RDS, a protein of the photoreceptor outer membrane mutations of which are causative of certain forms of slow retinal degeneration. MW: 57 kD Mouse IgG1 SR: most mammals Immunogen: recombinant rat peripherin expressed in and purified from E. coli |
PhosphoSolutions |
100 µl |
354 €
|
| 1631-PER |
WB, IF Peripherin is an approx. 57kDa intermediate filament subunit found initially in sensory neurons of the peripheral nervous systems, which gives the protein its name. Subsequently, peripherin was found in some sensory and other neurons of the central nervous system and also in PC12 cells. Peripherin is also expressed in certain neuroendocrine tumors and in the insulin producing cells of the pancreas. Peripherin belongs to the Class III family of intermediate filament subunits which also includes vimentin, glial fibrillary acidic protein (GFAP) and desmin. In contrast to the neurofilaments, peripherin is strongly up-regulated after nerve injury. Antibodies to peripherin can be used in identifying, classifying, and studying neurons throughout the nervous system. Peripherin is also a good diagnostic marker for ballooned axons seen in Lou Gehrig's disease (Amyotrophic lateral sclerosis) and some neuronally derived tumors. Autoantibodies to peripherin are frequently seen in the sera of patients with diabetes. Peripherin is not related to peripherin/RDS, a protein of the photoreceptor outer membrane mutations of which are causative of certain forms of slow retinal degeneration. MW: 57 kD Chicken SR: most mammals Immunogen: recombinant rat peripherin expressed in and purified from E. coli |
PhosphoSolutions |
100 µl |
354 €
|
|
2031-MGLUR1A |
WB, IHC The metabotropic glutamate receptors (mGluRs) are key receptors in the modulation of excitatory synaptic transmission in the central nervous system. Rabbit IgG SR: rat Immunogen: Synthetic peptide from the C-terminus region of rat mGluR1a |
PhosphoSolutions |
100 µl |
416 €
|
| 1933-SYB |
WB, IHC Synaptobrevin (aka VAMP) is an integral membrane protein of synaptic vesicles that plays a major role in the formation of larger SNARE complexes, along with SNAP-25 and syntaxin. Synaptobrevin has been shown to be essential for two fast synapse-specific membrane trafficking processes: fast exocytosis for neurotransmitter release and fast endocytosis that mediates rapid recycling of synaptic vesicles (Deak et al., 2004). Decreased levels of synaptobrevin in human hippocampus and cortex have been correlated with cognitive defects in Alzheimer's disease (Sze et al., 2000). MW: 16 kD Mouse IgM SR: rat, mouse, human, bovine, porcine, rabbit Immunogen: synaptic immunoprecipitate (crude) from human brain |
PhosphoSolutions |
100 µl |
419 €
|
|
811-GA1C |
WB GABAA-Rs are important therapeutic targets for a range of sedative, anxiolytic, and hypnotic agents and are implicated in several diseases. Rabbit IgG SR: rat, human, bovine Immunogen: Fusion protein from the Cytoplasmic Loop of the a1-subunit of rat GABAA Receptor |
PhosphoSolutions |
100 µl |
416 €
|
|
812-GA1N |
WB GABAA-Rs are important therapeutic targets for a range of sedative, anxiolytic, and hypnotic agents and are implicated in several diseases. Rabbit IgG SR: rat, bovine Immunogen: Synthetic peptide from the N-terminus region of the alpha1-subunit of rat GABAA Receptor |
PhosphoSolutions |
100 µl |
416 €
|
| 1621-PERI |
WB, IHC Periostin is a matricellular protein, i.e. an extracellular matrix protein that interacts both with other ECM proteins and with cell-surface receptors. Like many other matricellular proteins, the function of periostin is important both in embryonic development and in the remodeling of adult tissues in response to pathological insults. Periostin was originally isolated as an osteoblast-specific marker that functions as a cell adhesion molecule for preosteoblasts and is thought to be involved in osteoblast recruitment, attachment and spreading (Kruzynska-Frejtag A. et al., 2004). Periostin has since been demonstrated to be important in heart valve development and myocardial infarction because it promotes collagen fibrogenesis, inhibits differentiation of progenitor cells into cardiomyocytes and is essential in maintaining the biomechanical properties of the adult myocardium (Norris et al., 2008). MW: 93 kD Rabbit SR: rat, mouse, human, chicken Immunogen: bacterial fusion protein equivalent to a 188-amino acid polypeptide from the Cterminal region of mouse periostin which is comprised of six small alternatively-spliced exons |
PhosphoSolutions |
100 µl |
419 €
|
| 1622-PERI |
WB, IHC Periostin is a matricellular protein, i.e. an extracellular matrix protein that interacts both with other ECM proteins and with cell-surface receptors. Like many other matricellular proteins, the function of periostin is important both in embryonic development and in the remodeling of adult tissues in response to pathological insults. Periostin was originally isolated as an osteoblast-specific marker that functions as a cell adhesion molecule for preosteoblasts and is thought to be involved in osteoblast recruitment, attachment and spreading (Kruzynska-Frejtag A. et al., 2004). Periostin has recently been shown to promote collagen fibrogenesis, inhibit differentiation of progenitor cells into cardiomyocytes and to be essential in maintaining the biomechanical properties of the adult myocardium (Norris et al., 2008). MW: 93 kD Rabbit SR: rat, mouse, human, chicken Immunogen: synthetic peptide from fasciclin domain 1 of mouse periostin |
PhosphoSolutions |
100 µl |
419 €
|
|
1505-STAR |
WB Stargazin is a member of the transmembrane AMPAR regulatory proteins (TARP) family and is involved in glutamate receptor trafficking. Rabbit IgG SR: rat Immunogen: synthetic peptide corresponding to amino acid residues from the C-terminal region of rat stargazin |
PhosphoSolutions |
100 µl |
416 €
|
|
2025-THRAB |
WB, IF, IHC TH antibodies can be used as markers for dopaminergic and noradrenergic neurons in a variety of applications. Rabbit IgG SR: mammalian, some invertebrates Immunogen: SDS-denatured rat tyrosine hydroxylase, purified from pheochromocytoma |
PhosphoSolutions |
100 µl |
416 €
|
|
2027-THSHP |
WB, IF, IHC TH antibodies can be used as markers for dopaminergic and noradrenergic neurons in a variety of applications. Sheep IgG SR: mammalian, some invertebrates Immunogen: Native rat tyrosine hydroxylase, purified from pheochromocytoma |
PhosphoSolutions |
100 µl |
416 €
|
| 125-ACT |
WB, IF, IHC Actin is the most abundant protein found in virtually all eukaryotic cells. It is also one of the most highly-conserved proteins, differing by no more than 20% in species as diverse as algae and humans, making it an excellent choice for use as a loading control. It is the monomeric subunit of microfilaments, one of the three major components of the cytoskeleton, and of thin filaments, which are part of the contractile apparatus in muscle cells. Thus, actin participates in many important cellular functions, including muscle contraction, cell motility, cell division and cytokinesis, vesicle and organelle movement, cell signaling, and the establishment and maintenance of cell junctions and cell shape. MW: 42 kD Mouse IgG1 SR: xenopus, drosophila, zebra fish, most mammals, some invertebrates Immunogen: Chicken gizzard actin |
PhosphoSolutions |
100 µl |
354 €
|
|
P1148-783 |
WB, IF Ser783 plays a critical role in enhancing neuronal survival after ischemia as phosphorylation of Ser783 is evident in many brain regions and is increased dramatically after ischemic injury to the brain. Rabbit IgG SR: rat Immunogen: synthetic phosphopeptide corresponding to amino acid residues surrounding the phospho-Ser783 of GABA B R2 |
PhosphoSolutions |
100 µl |
416 €
|
|
P1148-892 |
WB GABAB receptors are heterodimeric G protein-coupled receptors that mediate slow synaptic inhibition in the central nervous system. Rabbit IgG SR: rat, mouse, human Immunogen: Synthetic phosphopeptide corresponding to amino acid residues surrounding the pSer892 of the GABAB Receptor, R2-subunit |
PhosphoSolutions |
100 µl |
416 €
|
|
700-GLY |
WB, IHC Glycine receptors are members of the ligand-gated ion channel family (LGICs) that mediate rapid chemical neurotransmission. Rabbit IgG SR: rat Immunogen: Synthetic peptide from the N-terminus region of the alpha 1-subunit of rat Glycine Receptor |
PhosphoSolutions |
200 µg |
416 €
|
| 1454-NFM |
WB, IF Neurofilaments are the 10nm or intermediate filament proteins found specifically in neurons, and are composed predominantly of three major proteins called NF-L, NF-M and NF-H. NF-M is the neurofilament middle or medium molecular weight polypeptide and runs on SDS-PAGE gels at 145-160 kDa, with some variability across species boundaries. Antibodies to NF-M are useful for identifying neuronal cells and their processes in tissue sections and in tissue culture. NF-M antibodies can also be useful to visualize neurofilament accumulations seen in many neurological diseases, such as Amyotrophic Lateral Sclerosis (Lou Gehrig's disease) and Alzheimer's disease. MW: 145 kD Mouse IgG1 SR: rat, mouse, human, chicken Immunogen: recombinant fusion protein containing the extreme C-terminus of rat NF-M expressed in and purified from E. coli |
PhosphoSolutions |
100 µl |
354 €
|
| 1455-NFM |
WB, IF Neurofilaments are the 10nm or intermediate filament proteins found specifically in neurons, and are composed predominantly of three major proteins called NF-L, NF-M and NF-H. NF-M is the neurofilament middle or medium molecular weight polypeptide and runs on SDS-PAGE gels at 145-160 kDa, with some variability across species boundaries. Antibodies to NF-M are useful for identifying neuronal cells and their processes in tissue sections and in tissue culture. NF-M antibodies can also be useful to visualize neurofilament accumulations seen in many neurological diseases, such as Amyotrophic Lateral Sclerosis (Lou Gehrig's disease) and Alzheimer's disease. MW: 145 kD Chicken SR: rat, mouse, human, chicken Immunogen: recombinant fusion protein containing the extreme C-terminus of rat NF-M expressed in and purified from E. coli |
PhosphoSolutions |
100 µl |
354 €
|
| 325-CNP |
WB, IHC 2,3-cyclic nucleotide-3-phosphodiesterase (CNP) is a membrane bound, microtubule associated protein that is among the most abundant myelin proteins of the CNS. It is thought that CNP may serve as a regulator of tubulin polymerization and of microtubule distribution (Bifulco et al., 2002). It was recently found that CNP may also function as a possible linker protein anchoring microtubules to the plasma membrane via a 13 residue C-terminal CNP fragment (Bifulco et al., 2002, Esposito et al., 2008). MW: 46 kD Rabbit SR: rat, mouse, human, sheep, rabbit Immunogen: endogenous rabbit 2,3-cyclic nucleotide-3-phospho-diesterase |
PhosphoSolutions |
50 µl |
354 €
|
|
P1010-133 |
WB A variety of protein kinases phosphorylate CREB at serine 133 (Ser133), and phosphorylation of Ser133 is required for CREB-mediated transcription. Rabbit IgG SR: rat Immunogen: synthetic phosphopeptide corresponding to amino acid residues surrounding the phospho-Ser133 of CREB |
PhosphoSolutions |
100 µl |
416 €
|
|
P112-261 |
WB Recently, serine-261 has been identified as a novel phosphorylation site on AQP2 and levels of phosphorylated S261 have been shown to decrease with vasopressin treatment suggesting its involvement in vasopressin-dependent AQP2 trafficking. Rabbit IgG SR: rat Immunogen: synthetic phosphopeptide corresponding to amino acid residues surrounding the phospho-Ser261 of rat aquaporin-2 |
PhosphoSolutions |
100 µl |
416 €
|
| P112-264 |
WB, IHC Aquaporin 2 (AQP2) is a hormonally regulated water channel located in the renal collecting duct. Mutations in the AQP2 gene cause hereditary nephrogenic diabetes insipidus in humans (Iolascon et al., 2007). A vasopressin induced cAMP increase results in the phosphorylation of AQP2 at serine-256 and its translocation from the intracellular vesicles to the apical membrane of principal cells (van Balkom et al., 2002). Recently, serine-264 has been identified as a novel phosphorylation site on AQP2 and shown to be regulated by vasopressin thus implicating this site as important in AQP2 trafficking and subcellular distribution (Fenton RA et al., 2008). Rabbit SR: rat, mouse, human, bovine, chicken, non-human primate, canine Immunogen: synthetic phospho-peptide corresponding to amino acid residues surrounding the phospho-Ser264 of rat aquaporin 2 |
PhosphoSolutions |
100 µl |
419 €
|
| P112-269 |
WB, IHC Aquaporin 2 (AQP2) is a hormonally regulated water channel located in the renal collecting duct. Mutations in the AQP2 gene cause hereditary nephrogenic diabetes insipidus in humans (Iolascon et al., 2007). A vasopressin induced cAMP increase results in the phosphorylation of AQP2 at serine-256 and its translocation from the intracellular vesicles to the apical membrane of principal cells (van Balkom et al., 2002). Serine-269 has been recently identified as a vasopressin-mediated phosphorylation site on AQP2 and as such has shown to potentiate plasma membrane retention of AQP2 (Hoffert JD et al., 2008). Rabbit SR: rat, mouse, bovine, canine Immunogen: synthetic phospho-peptide corresponding to amino acid residues surrounding the phospho-Ser269 of rat aquaporin 2 |
PhosphoSolutions |
100 µl |
419 €
|
|
P135-15 |
WB The ability of cdc2 to exercise control over the cell cycle is dependent upon the phosphorylation of Tyr15 in cdc2. Rabbit IgG SR: rat, mouse, human, Xenopus, Drosophila Immunogen: Synthetic phosphopeptide corresponding to amino acid residues surrounding the pTyr15 of rat cdc2 |
PhosphoSolutions |
100 µl |
416 €
|
|
868-GDN |
WB, IHC, IP GABAA-Rs are important therapeutic targets for a range of sedative, anxiolytic, and hypnotic agents and are implicated in several diseases. Rabbit IgG SR: rat, mouse Immunogen: fusion protein from the N-terminus of the delta-subunit of rat GABAA receptor |
PhosphoSolutions |
100 µl |
416 €
|
| 308-CDK5 |
WB, IHC The neuronal protein kinase, Cdk5 has been implicated in a vast array of normal neuronal functions including regulation of neurotransmitter synthesis (Kansy J et al., 2004), the presynaptic vesicle cycle (Nguyen, C. & Bibb, JA 2003), neurotransmitter receptor trafficking and dopamine neurotransmission (Bibb, JA et al. 1999). At the same time Cdk5 has been implicated in a plethora of neurological and neuropsychiatric disorders including Alzheimer's, Parkinson's, Huntington's, epilepsy, schizophrenia, and drug addiction. Detection of Cdk5 in normal samples as well as tissue undergoing neurodegeneration may advance studies in these areas. Moreover, this antibody may allow more accurate postmortem evaluations of Cdk5 protein expression, and thus serve as a valuable new reagent for neuropathology. MW: 28 kD Mouse IgG SR: rat, mouse, human Immunogen: purified Cdk5 |
PhosphoSolutions |
100 µl |
419 €
|
| 1936-SYNJ |
WB, IHC Synaptojanin is a phosphatidylinositol phosphatase involved in clathrinmediated endocytosis of synaptic vesicles. Synaptojanin 1 has two alternatively spliced isoforms, one that is approx. 145 kDA and is exclusively expressed in neurons, and the other approx. 170 kDa which is expressed in non-neuronal, peripheral tissues (Ramjaun AR & McPherson PS, 1996). The gene which encodes Synaptojanin 1, SYNJ1, has been mapped to chromosome 21 thus making it a candidate for involvement in Down's syndrome (DS). It has recently been demonstrated that Ts65Dn mice (the most commonly used model of DS) have altered phosphatidylinositol-4,5-bisphosphate metabolism. This defect is rescued by restoring SYNJ1 to disomy in the Ts65Dn mice (Voronov SV et al., 2008). MW: 145 kD Mouse IgG SR: rat Immunogen: recombinant protein corresponding to amino acid residues from the C-terminal region of rat synaptojanin 1 |
PhosphoSolutions |
100 µl |
419 €
|
| 1685-PROX1 |
IHC Prox1 (Prospero-related homeobox 1) is a divergent homeogene that regulates cell proliferation, fate determination and differentiation during vertebrate embryonic development. The protein is expressed in the developing lens and is also detected in embryonic brain, lung, liver and kidney, while in adult it is more abundant in heart and liver than in brain, skeletal muscle, kidney and pancreas (Chen et al., 2006). Prox1 is thought to play a fundamental role in early development of the CNS and may regulate gene expression and development of postmitotic undifferentiated young neurons (Misra et al., 2008). Mouse IgG SR: rat, mouse, human, chicken Immunogen: recombinant human Prox1 protein |
PhosphoSolutions |
100 µl |
419 €
|
| 465-DSBA-L |
WB, IHC Disulfide-bond-A oxidoreductase-like protein (DsbA-L, previously named as GST Kappa) is an adiponectin-interacting protein. DsbA-L is highly expressed in adipose tissue, and its expression level is negatively correlated with obesity in mice and humans. DsbA-L expression in 3T3-L1 adipocytes is stimulated by the insulin sensitizer rosiglitazone and inhibited by the inflammatory cytokine TNFalpha. Polymorphism of DsbA-L gene has recently been implicated in insulin secretion and body fat distribution (Gao F et al., 2009). Overexpression of DsbA-L promotes adiponectin multimerization while suppressing DsbA-L expression by RNAi markedly and selectively reduces adiponectin levels and secretion in 3T3-L1 adipocytes. Recent studies identify DsbA-L as a key regulator for adiponectin biosynthesis (Liu et al., 2008). MW: 25 kD Rabbit SR: mouse, human Immunogen: full length recombinant mouse DsbA-L protein |
PhosphoSolutions |
100 µl |
354 €
|
| 1537-OLIG1 |
WB, IHC, IP Olig genes have been identified as the earliest known markers of oligodendrocyte lineage determination to date (Zhou et al., 2000). Olig1 is a transcription factor which promotes formation and maturation of oligodendrocytes, especially within the brain. It is expressed in the ventral spinal cord as early as 9.5 dpc and by 15.5 dpc, olig1 is dispersed throughout the gray matter. In the postnatal brain, it is present preferentially in the white matter, such as corpus callosum and cerebellar medulla. Olig1 has been demonstrated as necessary in the repair of brain lesions in patients with multiple sclerosis (Arnett et al. 2004). MW: 27 kD Rabbit IgG SR: rat, mouse Immunogen: recombinant Olig1 |
PhosphoSolutions |
100 µl |
419 €
|
|
1525-NSF |
WB NSF (N-ethylmaleimide sensitive fusion protein) is a critical component of the SNARE (soluble NSF attachment protein receptors) protein complex that is involved in synaptic vesicle trafficking. Rabbit IgG SR: rat Immunogen: synthetic peptide corresponding to amino acid residues from the C-terminal region of rat NSF |
PhosphoSolutions |
100 µl |
416 €
|
| 1105-MARCKS |
WB, IF Myristoylated Alanine-Rich C Kinase Substrate (MARCKS) is a major substrate for phosphorylation by protein kinase C (PKC) (Ouimet et al.,1990) and is concentrated in synapses of neurons. It appears to function in synaptic vesicle cycling and has been shown to bind both actin and calmodulin in vitro (Hartwig et al. 1992). Deletion of the MARCKS gene in mice results in embryonic brain defects and death (Stumpo et al. 1995). MARCKS is a member of a family of calmodulin binding proteins and phosphorylation of Ser152/156 modulates the binding of MARCKS to calmodulin (Verghese et al., 1994). MW: 80 kD Rabbit SR: rat Immunogen: recombinant MARCKS expressed in and purified from E. coli |
PhosphoSolutions |
100 µl |
354 €
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|
P1185-1526 |
WB Myristoylated Alanine-Rich C Kinase Substrate (MARCKS) is a major substrate for phosphorylation by Protein Kinase C (PKC). Rabbit IgG SR: rat, mouse, human, Xenopus Immunogen: Synthetic phosphopeptide corresponding to amino acid residues surrounding the pSer152,156 of MARCKS |
PhosphoSolutions |
100 µl |
416 €
|
| P1230-862 |
WB Metabotropic glutamate receptors (mGluRs) are key receptors in the modulation of excitatory synaptic transmission in the central nervous system. They are implicated in many forms of neural plasticity as well as learning and memory and drug abuse (Bhattacharya et al., 2004, Francesconi et al., 2004, Wilson and Nicoll, 2001). The mGluRs are divided into three groups based on sequence identity and pharmacological properties: group I (mGluR1 and mGluR5) are localized in the perisynaptic region of the postsynaptic membrane, whereas group II (mGlur2 and mGluR3) and group III (mGluR4,6,7 and 8) are localized predominantly at presynaptic terminals. PKC phosphorylation of serine 862 on mGluR7 has been shown to be critical for stabilizing receptor surface expression and promoting binding to the synaptic PDZ-domain-containing protein PICK1 (Suh et al., 2008). MW: 102 kD Rabbit SR: rat, mouse, human, bovine, non-human primate, zebra fish, canine Immunogen: synthetic phospho-peptide corresponding to amino acid residues surrounding phospho-Ser862 of rat mGluR7 |
PhosphoSolutions |
100 µl |
419 €
|
|
1825-RBP |
WB Rabphilin-3A is a peripheral membrane protein that binds Ca2+ and phospholipids and is attached to synaptic vesicle membranes. Rabbit IgG SR: rat Immunogen: synthetic peptide corresponding to amino acid residues from the C-terminal region of rabphilin 3A |
PhosphoSolutions |
100 µl |
416 €
|
| 303-CAL |
WB, IHC Calretinin is a calcium-binding protein involved in calcium signaling. It is abundantly expressed throughout the central nervous system, retina and many other tissues. Studies have shown that calretinin may play a role in neuroprotection by buffering intracellular calcium (Lukas and Jones 1994, Weisenhorn et al., 1996). Additionally, calretinin selectively stains mesothelial cells thus making it an important marker for differentiating malignant mesothelioma from carcinomas (Attanoos et al., 2000). MW: 29 kD Sheep SR: rat, mouse, human, non-human primate Immunogen: purified guinea pig calretinin |
PhosphoSolutions |
100 µl |
419 €
|
|
863-GB3C |
WB GABAA-Rs are important therapeutic targets for a range of sedative, anxiolytic, and hypnotic agents and are implicated in several diseases. Rabbit IgG SR: rat, human, bovine Immunogen: Fusion protein from the Cytosolic Loop of the beta3-subunit of rat GABAA Receptor |
PhosphoSolutions |
100 µl |
416 €
|
| P1130-4089 |
WB Gamma-aminobutyric acid (GABA) is the primary inhibitory neurotransmitter in the central nervous system. There are two major classes of GABA receptors: the GABAA and the GABAB subtype of receptors. GABAA-Rs are important therapeutic targets for a range of sedative, anxiolytic, and hypnotic agents and are implicated in several diseases including epilepsy, anxiety, depression, and sub-stance abuse. The GABAA-R is a multimeric subunit complex. To date six alphas, four betas and four gammas, plus alternative splicing variants of some of these subunits, have been identified (Olsen and Tobin, 1990, Whiting et al., 1999, Ogris et al., 2004). Injection in oocytes or mammalian cell lines of cRNA coding for alpha- and beta-subunits results in the expression of functional GABAA-Rs sensitive to GABA. However, coexpression of a gamma-subunit is required for benzodiazepine modulation. Phosphorylation of serine 408 and serine 409 within the beta 3 subunit have been shown to be critical for the functional modulation of beta 3 containing recombinant receptors (Brandon et al., 2000). MW: 53 kD Rabbit SR: rat, mouse, human, xenopus, bovine, chicken, non-human primate, zebra fish, canine Immunogen: synthetic phospho-peptide corresponding to amino acid residues surrounding the di-phospho-Ser408/409 of the rat GABAA receptor, beta 3 subunit |
PhosphoSolutions |
100 µl |
419 €
|
|
862-GB2C |
WB GABAA-Rs are important therapeutic targets for a range of sedative, anxiolytic, and hypnotic agents and are implicated in several diseases. Rabbit IgG SR: rat, human, bovine Immunogen: Fusion protein from the Cytosolic Loop of the beta2-subunit of rat GABAA Receptor |
PhosphoSolutions |
100 µl |
416 €
|
|
1502-NR2C |
WB The NMDAR plays an essential role in memory, neuronal development and it has also been implicated in several disorders of the central nervous system. Rabbit IgG SR: rat, human Immunogen: Fusion protein from the N-terminus of the NR2C-subunit of rat NMDA Receptor |
PhosphoSolutions |
10 µg |
416 €
|
| P1518-1096 |
WB The ion channels activated by glutamate that are sensitive to N-methyl-D-aspartate (NMDA) are designated NMDA receptors (NMDAR). The NMDAR plays an essential role in memory, neuronal development and it has also been implicated in several disorders of the central nervous system including Alzheimer's, epilepsy and ischemic neuronal cell death (Grosshans et al., 2002, Wenthold et al., 2003, Carroll and Zukin, 2002). The NMDA receptor is also one of the principal molecular targets for alcohol in the CNS (Lovinger et al., 1989, Alvestad et al., 2003, Snell et al., 1996). The NMDAR is also potentiated by protein phosphorylation (Lu et al., 1999). The NR2C subunit of the receptor is thought to influence the NMDAR conductance level (Ebralidze et al., 1996). Phosphorylation of Ser1096 by PKB on NR2C has been recently demonstrated to regulate NMDA receptor binding to 14-3-3 (Chen & Roche 2009). MW: 140 kD Rabbit SR: rat, mouse, human, bovine, non-human primate, canine Immunogen: synthetic phospho-peptide surrounding the phospho Ser1096 of the NR2C-subunit of rat NMDA receptor |
PhosphoSolutions |
100 µl |
419 €
|
| P1518-1244 |
WB The ion channels activated by glutamate that are sensitive to N-methyl-D-aspartate (NMDA) are designated NMDA receptors (NMDAR). The NMDAR plays an essential role in memory, neuronal development and it has also been implicated in several disorders of the central nervous system including Alzheimer's, epilepsy and ischemic neuronal cell death (Grosshans et al., 2002, Wenthold et al., 2003, Carroll and Zukin, 2002). The NMDA receptor is also one of the principal molecular targets for alcohol in the CNS (Lovinger et al., 1989, Alvestad et al., 2003, Snell et al., 1996). The NMDAR is also potentiated by protein phosphorylation (Lu et al., 1999). The NR2C subunit of the receptor is thought to influence the NMDAR conductance level (Ebralidze et al., 1996). Phosphorylation of Ser1244 has been shown to regulate NMDA receptor channel function (Chen et al., 2006). MW: 140 kD Rabbit SR: rat, mouse, human, bovine, non-human primate, canine Immunogen: synthetic phospho-peptide surrounding the phospho Ser1244 of the NR2C-subunit of rat NMDA receptor |
PhosphoSolutions |
100 µl |
419 €
|
| 620-GFAP |
WB, IF Glial Fibrillary Acidic Protein (GFAP) was discovered by Amico Bignami and co-workers as a major fibrous protein of multiple sclerosis plaques. It was subsequently found to be a member of the 10nm or intermediate filament (IF) family, specifically the IF family Class III, which also includes peripherin, desmin and vimentin. GFAP is strongly and specifically expressed in astrocytes and certain other astroglia in the CNS, in satellite cells, peripheral ganglia, and in non-myelinating Schwann cells in peripheral nerves. In many damage and disease states GFAP expression is heavily upregulated in astrocytes. In addition, neural stem cells frequently strongly express GFAP. Point mutations in the protein coding region of the GFAP gene lead to Alexander disease which is characterized by the presence of abnormal astrocytes containing GFAP protein aggregates known as Rosenthal fibers. MW: 50 kD Rabbit SR: rat, mouse, human Immunogen: recombinant and purified bovine GFAP |
PhosphoSolutions |
100 µl |
354 €
|
| 621-GFAP |
WB, IF Glial Fibrillary Acidic Protein (GFAP) was discovered by Amico Bignami and co-workers as a major fibrous protein of multiple sclerosis plaques. It was subsequently found to be a member of the 10nm or intermediate filament (IF) family, specifically the IF family Class III, which also includes peripherin, desmin and vimentin. GFAP is strongly and specifically expressed in astrocytes and certain other astroglia in the CNS, in satellite cells, peripheral ganglia, and in non-myelinating Schwann cells in peripheral nerves. In many damage and disease states GFAP expression is heavily upregulated in astrocytes. In addition, neural stem cells frequently strongly express GFAP. Point mutations in the protein coding region of the GFAP gene lead to Alexander disease which is characterized by the presence of abnormal astrocytes containing GFAP protein aggregates known as Rosenthal fibers. MW: 50 kD Chicken SR: rat, mouse, human Immunogen: recombinant and purified bovine GFAP |
PhosphoSolutions |
100 µl |
354 €
|
| P1551-940.100 |
WB Protein function: Mediates electroneutral potassium-chloride cotransport in mature neurons. Transport occurs under isotonic conditions, but is activated 20-fold by cell swelling. Important for Cl(-) homeostasis in neurons. Necessary for the ontogenic change in response to gamma-aminobutyric acid (GABA) from depolarization to hyperpolarization during neuronal development. [The UniProt Consortium] Rabbit IgG SR: rat Immunogen: phosphopeptide corresponding to amino acid residues surrounding the phospho-Ser940 of rat KCC2 |
PhosphoSolutions |
100 µl |
416 €
|
| 115-ABCA4 |
WB, IHC ABCA4 (ATP-binding cassette, sub-family A (ABC1), member 4, Rim Protein) is a member of the superfamily of ATP-binding cassette (ABC) transporters (Illing et al., 1997). ABC proteins transport various molecules across extra- and intracellular membranes. This protein is a retina-specific ABC transporter with N-retinylidene-PE as a substrate. It is expressed exclusively in retina photoreceptor cells, indicating the gene product mediates transport of an essential molecule across the photoreceptor cell membrane. Mutations in this gene are found in patients diagnosed with Stargardt disease and are associated with retinitis pigmentosa-19 and age-related macular degeneration (Wiszniewski et al., 2003). Defects in ABCA4 are the cause of Stargardt disease type 1 (STGD1) (Molday et al., 2000). STGD is one of the most frequent causes of macular degeneration in childhood. Defects in ABCA4 are also known to cause fundus flavimaculatus (FFM), age-related macular degeneration type 2 (ARMD2) and cone-rod dystrophy type 3 (CRD3) (Klevering et al., 2005). MW: 220 kD Mouse IgG SR: mouse, human. xenopus, bovine Immunogen: partially purified bovine 220-kDa disc rim protein |
PhosphoSolutions |
100 µl |
419 €
|
| 1447-NET |
WB Norepinephrine Transporter [NET] (or noradrenaline transporter (NAT)) is a monoamine transporter that transports the neurotransmitter noradrenaline from the synapse back to its vesicles for storage until later use. It also appears to transport the neurotransmitter dopamine in the same way, but to a lesser degree. Studies have shown a decrease in NET levels in the locus coeruleus in patients diagnosed with major depression (Klimek et al., 1997). Cocaine, amphetamines and many therapeutic antidepressants, such as the SNRIs (Serotonin-norepinephrine reuptake inhibitors) and the tricyclic antidepressants (TCAs) act to raise noradrenaline. Furthermore, deficits in the NET gene have been associated with ADHD (Kim et al., 2006). MW: 55 kD Mouse IgG SR: rat, mouse Immunogen: synthetic peptide from mouse norepinephrine transporter |
PhosphoSolutions |
100 µl |
419 €
|
| 311-CGRP |
ICC Calcitonin Gene Related Peptide [CGRP] is a 37 amino acid peptide and is the most potent endogenous vasodilator currently known (Brain et al.,1985). CGRP is primarily produced in nervous tissue, however, its receptors are expressed throughout the body. CGRP is also strongly implicated in the vasodilatory effect of endogenous cannabinoid anandamide in the brain. This effect was found to be antagonized by capsazepine. CGRP is also currently a major target of research in regards to factors effecting the onset of migraine headaches (Edvinsson L., 2003). CGRP antibodies have been used successfully in immunoneutralization (Wong et al., 1993). Mouse IgG2a SR: rat, human, most mammals Immunogen: Rat alpha-CGRP |
PhosphoSolutions |
100 µl |
419 €
|
|
2015-TPH |
WB, IHC TPH can be used as an indicator of the localization of serotonin and melatonin in brain. Sheep IgG SR: human, rat Immunogen: recombinant rabbit tryptophan hydroxylase |
PhosphoSolutions |
100 µl |
416 €
|
|
1925-SYNP |
WB, IF, IP, IHC Synapsin I plays a key role in synaptic plasticity in brain. Rabbit IgG SR: rat, mouse, human Immunogen: native protein purified from bovine brain |
PhosphoSolutions |
10 µg |
416 €
|
|
1927-SYNP |
WB Synapsin I plays a key role in synaptic plasticity in brain. Rabbit IgG SR: human, mouse, rat Immunogen: native protein from bovine brain |
PhosphoSolutions | 50 µl |
352 €
|
|
846-GA5C |
WB GABAA-Rs are important therapeutic targets for a range of sedative, anxiolytic and hypnotic agents. Rabbit IgG SR: rat, mouse Immunogen: Fusion protein from the cytoplasmic loop of the alpha5-subunit of rat GABAA receptor |
PhosphoSolutions |
100 µl |
416 €
|
| 100-AIN |
WB, IF, IHC Alpha-internexin is a Class IV intermediate filament originally discovered as it co-purifies with other neurofilament subunits. Alpha-internexin is related to but distinct from the better known neurofilament triplet proteins, NF-L, NF-M and NF-H, having similar protein sequence motifs and a similar intron organization. It is expressed only in neurons and in large amounts early in neuronal development, but is down-regulated in many neurons as development proceeds. Many classes of mature neurons contain alpha-internexin in addition to NF-L, NF-M and NF-H. In some mature neurons alpha-internexin is the only neurofilament subunit expressed. Antibodies to alpha-internexin are therefore unique probes to study and classify neuronal types and follow their processes in sections and in tissue culture. In addition, recent studies show a marked up-regulation of alpha-internexin during neuronal regeneration. The use of antibodies to this protein in the study of brain tumors has not been examined to date, but is likely to be of interest. Recently Cairns et al. used this antibody to show that alpha-internexin is an abundant component of the inclusions of neurofilament inclusion body disease (NFID), a serious human neurodegenerative disorder. The antibody was also used to confirm the presence of circulating auto-antibodies to alpha-internexin in the sera of some patients with endocrine autoimmunity, as well as in some normal individuals. MW: 66 kD Mouse IgG1 Immunogen: recombinant rat alpha-internexin expressed in and purified from E. coli |
PhosphoSolutions |
100 µl |
354 €
|
| 101-AIN |
WB, IF Alpha-internexin is a Class IV intermediate filament originally discovered as it co-purifies with other neurofilament subunits. Alpha-internexin is related to but distinct from the better known neurofilament triplet proteins, NF-L, NF-M and NF-H, having similar protein sequence motifs and a similar intron organization. It is expressed only in neurons and in large amounts early in neuronal development, but is down-regulated in many neurons as development proceeds. Many classes of mature neurons contain alpha-internexin in addition to NF-L, NF-M and NF-H. In some mature neurons alpha-internexin is the only neurofilament subunit expressed. Antibodies to alpha-internexin are therefore unique probes to study and classify neuronal types and follow their processes in sections and in tissue culture. In addition, recent studies show a marked up-regulation of alpha-internexin during neuronal regeneration. The use of antibodies to this protein in the study of brain tumors has not been examined to date, but is likely to be of interest. Recently Cairns et al. used this antibody to show that alpha-internexin is an abundant component of the inclusions of neurofilament inclusion body disease (NFID), a serious human neurodegenerative disorder. The antibody was also used to confirm the presence of circulating auto-antibodies to alpha-internexin in the sera of some patients with endocrine autoimmunity, as well as in some normal individuals. MW: 66 kD Chicken IgY SR: mouse, human, rat Immunogen: recombinant rat alpha-internexin expressed in and purified from E. coli |
PhosphoSolutions |
100 µl |
354 €
|
|
880-GAT1 |
WB, IHC GAT-1, the most abundant GABA transporter, is found predominantly in neurons, but also in some specialized glia. GAT-1 is thought to play a key role in epileptogenesis. Rabbit IgG SR: rat Immunogen: synthetic peptide corresponding to amino acid residues from the C-terminal region of rat GAT-1 |
PhosphoSolutions |
100 µl |
416 €
|
| 2020-TUB |
WB, IHC Tubulin is the major constituent of microtubules, existing as a heterodimer of the alpha and beta subunits. The beta III isoform of tubulin is found almost exclusively in neuronal processes of adult tissues and is therefore an excellent marker for neurons. Neuron specific, posttranslational modifications within the C-terminal domain of beta III tubulin have been shown to be developmentally regulated suggesting that they may serve to modulate the interaction of tubulin with microtubule associated proteins (Lee et al., 1990). Additionally, beta III tubulin has been found to be highly expressed in cancer cells such as small cell lung cancer, large cell neuroendocrine carcinoma and adenocarcinomas and is correlated with an increasing histological degree of malignancy (Katsetos et al., 2003). MW: 55 kD Mouse IgG SR: most mammals Immunogen: synthetic peptide corresponding to beta III tubulin |
PhosphoSolutions |
100 µl |
419 €
|
| 317-CLAV |
WB, ICC Clavesin (clathrin vesicle associated Sec14 protein) is a novel neuron specific protein that has recently been identified and shown to be required for normal morphology of late endosomes and/or lysosomes as lentiviral-mediated knockdown of clavesin in hippocampal neurons causes lysosomal defects (Katoh et al., 2009). Additionally, upregulation of clavesin in human hepatocellular carcinoma has recently been demonstrated thus making it a useful marker for this disease state (Zhao et al., 2008). MW: 35 kD Rabbit SR: rat, mouse, human Immunogen: synthetic peptide taken from the C-terminus of rat clavesin 1 |
PhosphoSolutions |
100 µl |
419 €
|
|
2100-VGAT |
WB The Vesicular GABA Amino Acid Transporter (VGAT) is responsible for transport of the inhibitory neurotransmitter into synaptic vesicles. Rabbit IgG SR: rat Immunogen: synthetic peptide corresponding to amino acid residues from the N-terminal region of rat Vesicular GABA Transporter (VGAT) |
PhosphoSolutions |
100 µl |
416 €
|
|
860-GB1C |
WB GABAA-Rs are important therapeutic targets for a range of sedative, anxiolytic and hypnotic agents. Rabbit IgG SR: rat Immunogen: Fusion protein from the cytoplasmic loop of the beta1-subunit of rat GABAA receptor |
PhosphoSolutions |
100 µl |
416 €
|
|
830-GG2 |
WB GABAA-Rs are important therapeutic targets for a range of sedative, anxiolytic, and hypnotic agents and are implicated in several diseases. Rabbit IgG SR: rat, human, bovine Immunogen: Synthetic peptide representing a sequence that is specific for the gamma2-subunit of rat GABAA |
PhosphoSolutions |
50 µl |
416 €
|
|
832-GG2C |
WB GABAA-Rs are important therapeutic targets for a range of sedative, anxiolytic, and hypnotic agents and are implicated in several diseases. Rabbit IgG SR: rat, human, bovine Immunogen: Fusion protein from the Cytosolic Loop of the gamma2-subunit of rat GABAA Receptor |
PhosphoSolutions |
100 µl |
416 €
|
| P1130-327 |
WB Gamma-aminobutyric acid (GABA) is the primary inhibitory neurotransmitter in the central nervous system. There are two major classes of GABA receptors: the GABAA and the GABAB subtype of receptors. GABAA-Rs are important therapeutic targets for a range of sedative, anxiolytic, and hypnotic agents and are implicated in several diseases including epilepsy, anxiety, depression, and sub-stance abuse. The GABAA-R is a multimeric subunit complex. To date six alphas, four betas and four gammas, plus alternative splicing variants of some of these subunits, have been identified (Olsen and Tobin, 1990, Whiting et al., 1999, Ogris et al., 2004). Injection in oocytes or mammalian cell lines of cRNA coding for alpha- and beta-subunits results in the expression of functional GABAA-Rs sensitive to GABA. However, coexpression of a gamma-subunit is required for benzodiazepine modulation. It has recently been suggested that PKCepsilon regulates the sensitivity of GABAA alpha1beta2gamma2 receptors to ethanol and benzodiazepines through phosphorylation of serine 327 in the large intracellular loop of gamma 2 (Qi et al., 2007). MW: 45 kD Rabbit SR: rat, mouse, human, bovine, chicken, non-human primate, canine Immunogen: synthetic phospho-peptide corresponding to amino acid residues surrounding the phospho-Ser327 of the GABAA receptor, gamma2 subunit |
PhosphoSolutions |
100 µl |
419 €
|
|
824-GA3N |
WB GABAA-Rs are important therapeutic targets for a range of sedative, anxiolytic, and hypnotic agents and are implicated in several diseases including epilepsy, anxiety, depression, and sub-stance abuse Rabbit IgG SR: mouse, rat Immunogen: fusion protein from N-terminal region of the alpha3-subunit of rat GABA A receptor |
PhosphoSolutions |
100 µl |
416 €
|
|
P1550-503 |
WB, IHC Voltage-gated K+ channels are important determinants of neuronal membrane excitability. Rabbit IgG SR: rat, mouse Immunogen: synthetic phosphopeptide corresponding to amino acid residues surrounding the phospho-Ser503 potassium channel, voltage-gated, Kv3.1 subunit |
PhosphoSolutions |
100 µl |
416 €
|
|
417-DDC |
WB DDC antibodies can be used as markers for dopaminergic, noradrenergic and serotonergic neurons in a variety of applications. Rabbit IgG SR: rat Immunogen: SDS denatured, recombinant bovine aromatic DOPA Decarboxylase (DDC) |
PhosphoSolutions |
100 µl |
416 €
|
|
419-DDC |
WB DDC antibodies can be used as markers for dopaminergic, noradrenergic and serotonergic neurons in a variety of applications. Sheep IgG SR: rat, human, bovine, swine, dog, guinea pig Immunogen: SDS denatured recombinant bovine DOPA Decarboxylase (DDC) expressed in E. coli |
PhosphoSolutions |
100 µl |
416 €
|
| 881-GAT2 |
IHC GAT-2 is found in a wide range of neuronal and non-neuronal cells including dendrites and axon terminals as well as epithelial cells and cells forming the pia and arachnoid complex. Rabbit IgG SR: rat Immunogen: synthetic peptide corresponding to amino acid residues from the C-terminal region of rat GAT-2 |
PhosphoSolutions |
100 µl |
416 €
|
|
882-GAT3 |
WB, IHC GAT-3 has been found to be localized to astrocytes within the cerebral cortex indicating that this transporter mediates GABA uptake into glial cells. Rabbit IgG SR: rat Immunogen: synthetic peptide corresponding to amino acid residues from the C-terminal region of rat GAT-3 |
PhosphoSolutions |
100 µl |
416 €
|
|
1491-NACX |
WB The plasma membrane Na+/Ca2+ (NaCX) exchangers mediate Na+-dependent Ca2+ efflux in a wide variety of cell types. Mouse IgG2b SR: rat Immunogen: Fusion protein from the N-terminus of rabbit renal Na/Ca exchange |
PhosphoSolutions |
100 µg |
416 €
|
|
374-DARPP |
WB DARP-32 is a dopamine and cAMP-regulated 32k phosphoprotein that is associated with dopaminoceptive neurons. Rabbit IgG SR: rat Immunogen: synthetic peptide corresponding to amino acid residues from the N-terminal region of rat DARPP-32 |
PhosphoSolutions |
100 µl |
416 €
|
| P1025-137 |
WB DARPP-32 is a dopamine (DA) and cAMP-regulated approx. 32kD phosphoprotein that is associated with dopaminoceptive neurons (Fienberg et al., 1998). The protein inhibits protein phosphatase I when it is phosphorylated on Thr34. In contrast, when DARPP-32 is phosphorylated on Thr75 the protein acts as an inhibitor of PKA (Bibb et al., 1999). Phosphorylation of DARPP-32 is thought to play a critical role in the regulation of dopaminergic neurotransmission. In addition, the activity of DARPP-32 is also thought to play important roles in the actions of alcohol, caffeine and Prozac(R) (Maldve et al., 2002, Lindskog et al., 2002, Svenningsson et al., 2002). Serine 137 is phosphorylated by casein kinase 1 and phosphorylation of this site is increased following acute administration of Prozac(R) (Svenningsson et al., 2002). MW: 32 kD Rabbit SR: rat, mouse, human, bovine, chicken, non-human primate, canine Immunogen: synthetic phospho-peptide corresponding to amino acid residues surrounding the phospho-Ser137 of rat DARPP-32 |
PhosphoSolutions |
100 µl |
419 €
|
|
P1025-34 |
WB The protein inhibits protein phosphatase I when it is phosphorylated on Thr34. Rabbit IgG SR: rat, mouse, human, Xenopus Immunogen: Synthetic phosphopeptide corresponding to amino acid residues surrounding the pThr34 of DARPP-32 |
PhosphoSolutions |
100 µl |
416 €
|
|
P1025-75 |
WB When DARPP-32 is phosphorylated on Thr75 the protein acts as an inhibitor of PKA. Rabbit IgG SR: mouse, human Immunogen: Synthetic phosphopeptide corresponding to amino acid residues surrounding the pThr75 of DARPP-32 |
PhosphoSolutions |
100 µl |
416 €
|
|
822-GA2C |
WB GABAA-Rs are important therapeutic targets for a range of sedative, anxiolytic, and hypnotic agents and are implicated in several diseases including epilepsy, anxiety, depression, and sub-stance abuse Rabbit IgG SR: mouse, rat Immunogen: fusion protein from the cytoplasmic loop of the alpha2-subunit of rat GABA A receptor |
PhosphoSolutions |
100 µl |
416 €
|
|
840-GA2 |
WB GABAA-Rs are important therapeutic targets for a range of sedative, anxiolytic, and hypnotic agents and are implicated in several diseases. Rabbit IgG SR: rat, human, bovine Immunogen: Synthetic peptide representing a sequence that is specific for the alpha2-subunit of rat GABAA Receptor |
PhosphoSolutions |
50 µl |
352 €
|
|
844-GA4N |
WB GABAA-Rs are important therapeutic targets for a range of sedative, anxiolytic, and hypnotic agents and are implicated in several diseases. Rabbit IgG SR: rat Immunogen: Synthetic peptide from the N-terminal region of the alpha4-subunit of rat GABAA Receptor, |
PhosphoSolutions |
100 µl |
416 €
|
|
845-GA4C |
WB GABAA-Rs are important therapeutic targets for a range of sedative, anxiolytic, and hypnotic agents and are implicated in several diseases. Rabbit IgG SR: rat, human , bovine Immunogen: Fusion protein from the Cytosolic Loop of the alpha4-subunit of rat GABAA Receptor |
PhosphoSolutions |
100 µl |
416 €
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847-GA6C |
WB GABAA-Rs are important therapeutic targets for a range of sedative, anxiolytic, and hypnotic agents and are implicated in several diseases. Rabbit IgG SR: rat, human , bovine Immunogen: Fusion protein from the Cytosolic Loop of the alpha6-subunit of rat GABAA Receptor |
PhosphoSolutions |
100 µl |
416 €
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850-GA6 |
WB GABAA-Rs are important therapeutic targets for a range of sedative, anxiolytic, and hypnotic agents and are implicated in several diseases. Rabbit IgG SR: rat, human Immunogen: Synthetic peptide representing a sequence that is specific for the alpha6-subunit of rat GABAA Receptor |
PhosphoSolutions |
50 µl |
352 €
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1002-KV22 |
WB, IHC ( frozen ) Voltage-gated K+ channels are important determinants of neuronal membrane excitability. Rabbit IgG SR: Xenopus, rodent Immunogen: synthetic peptide from the subunit region of the potassium channel, voltage gated, Kv2.2 subunit of rat and Xenopus |
PhosphoSolutions |
100 µl |
416 €
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642-GRASP |
WB Recent work suggests that GRASP-1 may regulate neuronal ras signaling and contribute to the regulation of AMPA receptor distribution by NMDA receptor activity. Rabbit IgG SR: rat Immunogen: synthetic peptide corresponding to amino acid residues from the C-terminal region of rat GRASP |
PhosphoSolutions |
100 µl |
416 €
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| 1155-MIT |
WB, IF, IHC Mitochondria are most commonly known as the power plants of the cell as they produce ATP, but they are also involved in many other important cellular processes such as cell signaling, growth and differentiation (McBride et al., 2006). In addition, mitochondria have been shown to play a role in apoptosis (Green 1998). This antibody is an excellent marker for human cells in xenographic model research. It reacts specifically with human cells, including neurons and embryonic stem cells. MW: 60 kD Mouse IgG1 SR: human Immunogen: Human cell homogenate |
PhosphoSolutions |
100 µl |
354 €
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1433-P |
WB Rabbit IgG SR: rat Immunogen: synthetic peptide corresponding to amino acid residues from the C-terminal region of 14-3-3 protein |
PhosphoSolutions |
100 µl |
416 €
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| 1515-NPC |
IF The nuclear pore complex (NPC) is a very large structure made up of at least 50 different proteins that span the double membrane of the nuclear envelope functioning as a gateway for macromolecular traffic between the cytoplasm and the nucleus (Nakielny and Dreyfuss,1999). Discrete nuclear pore complex proteins or nucleoporins such as NUP98, NUP180 and p62 have been implicated in autoimmune disease and cancer. Patients with primary biliary cirrhosis (PBC) frequently produce autoantibodies against p62 and NUP180 (Wilken et al., 1993, Nesher et al., 2001) while NUP98 translocations have been found in patients with acute myelogenous leukemia (AML) (Jaju et al. 2001). Mouse IgG1 SR: rat, mouse, human, some invertebrates Immunogen: Yeast nuclear preparations |
PhosphoSolutions |
100 µl |
354 €
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| 1590-NUC |
IHC, IF This antibody is an excellent marker for human cells in xenographic model research. It reacts specifically with human cells, including neurons and embryonic stem cells, with no reactivity to rat or mouse cells. Mouse IgG1 SR: human Immunogen: Human cell homogenate |
PhosphoSolutions |
100 µl |
354 €
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1805-RAB3 |
WB Rab proteins belong to the Ras small GTPase superfamily. Rab3s are thought to play a key role in presynaptic vesicle trafficking and priming. Rabbit IgG SR: rat, mouse, human, Xenopus Immunogen: synthetic peptide corresponding to amino acid residues from the N-terminal region of rat Rab3 |
PhosphoSolutions |
100 µl |
416 €
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1850-RSK2 |
WB The p90 ribosomal S6 kinases (RSK) are downstream members of the extracellular signal-regulated kinase (ERK)/MAPK cascade. Rabbit IgG SR: rat Immunogen: synthetic peptide corresponding to amino acid residues from the C-terminal region of rat ribosmal S6 kinase 2 |
PhosphoSolutions |
100 µl |
416 €
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1950-SNT2 |
WB Whereas synaptophysin 1 is ubiquitiously expressed, synaptophysin 2 is concentrated in the mossy fiber synapses of the hippocampus. Rabbit IgG SR: rat Immunogen: synthetic peptide corresponding to amino acid residues from the C-terminal region of rat synaptophysin 2 |
PhosphoSolutions |
100 µl |
416 €
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2030-MGLUR2/3 |
WB, IHC The metabotropic glutamate receptors (mGluRs) are key receptors in the modulation of excitatory synaptic transmission in the central nervous system. Rabbit IgG SR: rat Immunogen: Synthetic peptide from the C-terminus region of rat mGluR2 and rat mGluR3 |
PhosphoSolutions |
100 µl |
416 €
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2032-MGLUR5/1 |
WB, IHC The metabotropic glutamate receptors (mGluRs) are key receptors in the modulation of excitatory synaptic transmission in the central nervous system. Rabbit IgG SR: rat Immunogen: Synthetic peptide from the C-terminus region of rat mGluR5 and rat mGluR1a |
PhosphoSolutions |
100 µl |
416 €
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500-ERK |
WB Extracellular-Signal Regulated Kinase/Mitogen-Activated Protein Kinase (ERK/MAPK) also is thought to play a key role in learning and memory. Rabbit IgG SR: rat Immunogen: synthetic peptide corresponding to amino acid residues from the C-terminal region of rat ERK/MAPK |
PhosphoSolutions |
100 µl |
416 €
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905-GLUR2/3 |
WB GluR1-4 belong to the class of AMPA receptors and play key roles in virtually all excitatory neurotransmission in the brain. Rabbit IgG SR: rat Immunogen: synthetic peptide corresponding to amino acid residues from the C-terminal region of rat GluR2/3 |
PhosphoSolutions |
100 µl |
416 €
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P1005-286 |
WB Phosphorylation of Thr286 on the kinase produces an autonomously active form of CaM Kinase II. Autophosphorylation of Thr305 inhibits the activity of CaM Kinase II. Rabbit IgG SR: rat, mouse, human, Xenopus Immunogen: Synthetic phosphopeptide corresponding to amino acid residues surrounding the pThr286 found in rat brain CaM Kinase II |
PhosphoSolutions |
100 µl |
416 €
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P1005-305 |
WB Phosphorylation of Thr286 on the kinase produces an autonomously active form of CaM Kinase II. Autophosphorylation of Thr305 inhibits the activity of CaM Kinase II. Rabbit IgG SR: rat, mouse, human, Xenopus, bovine, chicken Immunogen: Synthetic phosphopeptide corresponding to amino acid residues surrounding the pThr305 found in rat brain CaM Kinase II |
PhosphoSolutions |
100 µl |
352 €
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P1110-298 |
WB Recent work suggests that phosphorylation of a specific EphrinB residue (Tyr298) plays a key role in EphrinB signaling Rabbit IgG SR: rat Immunogen: synthetic phosphopeptide corresponding to amino acid residues surrounding the phospho-Tyr298 of EphrinB |
PhosphoSolutions |
100 µl |
416 €
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P1110-317 |
WB Chicken Tyr317 is the homologue of Tyr329 in human and mouse, and Tyr310 in Xenopus EphrinB. Rabbit IgG SR: rat Immunogen: synthetic phosphopeptide corresponding to amino acid residues surrounding the phospho-Tyr317 of chicken EphrinB |
PhosphoSolutions |
100 µl |
416 €
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P1110-331 |
WB Chicken Tyr331 is the homologue of Tyr343 in human and mouse, and Tyr324 in Xenopus EphrinB. Rabbit IgG SR: rat Immunogen: synthetic phosphopeptide corresponding to amino acid residues surrounding the phospho-Tyr331 of chicken EphrinB |
PhosphoSolutions |
100 µl |
416 €
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P1305-515 |
WB Munc18-1 is a neuron-specific member of the Sec1/Munc18 protein family that binds to syntaxin1A and is thought to stabilize the complex. Munc-18 is thought to be regulated by PKC phosphorylation of Ser515 on the Munc-18 protein. Rabbit IgG SR: rat Immunogen: synthetic phosphopeptide corresponding to amino acid residues surrounding the phospho-Ser515 of Munc-18 |
PhosphoSolutions |
100 µl |
416 €
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P1433-58 |
WB Recent studies have demonstrated that the dimeric status of the 14-3-3 protein is regulated by site-specific serine phosphorylation. Rabbit IgG SR: human, rat Immunogen: synthetic phosphopeptide corresponding to amino acid residues surrounding the phospho-Ser58 of rat 14-3-3 protein |
PhosphoSolutions |
100 µl |
416 €
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P155-383 |
WB Elk-1 is a transcription factor involved in mediating gene transcription in response to growth factors. Phosphorylation at Ser383 is essential for the transcriptional activity of Elk-1. Rabbit IgG SR: rat, mouse, human Immunogen: Synthetic phosphopeptide corresponding to amino acid residues surrounding the pSer383 of human Elk-1 |
PhosphoSolutions |
100 µl |
416 €
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P1553-234 |
WB Rabphilin can be phosphorylated at Ser234 by both CAM kinase II and PKA and this phosphorylation has been suggested to regulate neuronal activity during development in a synapse-specific manner. Rabbit IgG SR: rat Immunogen: synthetic phosphopeptide corresponding to amino acid residues surrounding the phospho-Ser234 of rabphilin 3A |
PhosphoSolutions |
100 µl |
416 €
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P1555-301 |
WB Recent work has demonstrated that phosphorylation regulates the downregulation of Raf with two sites participating: Ser301 and Ser642. Rabbit IgG SR: rat Immunogen: synthetic phosphopeptide corresponding to amino acid residues surrounding the phospho-Ser301 of rat Raf-1 |
PhosphoSolutions |
100 µl |
416 €
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P1555-642 |
WB Recent work has demonstrated that phosphorylation regulates the downregulation of Raf with two sites participating: Ser301 and Ser642. Rabbit IgG SR: rat Immunogen: synthetic phosphopeptide corresponding to amino acid residues surrounding the phospho-Ser642 of rat Raf-1 |
PhosphoSolutions |
100 µl |
416 €
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P1560-549 |
WB Ser 549 along with Ser 62 and Ser 67 are the sites of synapsin I that are phosphorylated by MAP kinase. Phosphorylation and subsequent dephosphorylation of this site is thought to play a key role in synaptic vesicle trafficking. Rabbit IgG SR: rat Immunogen: synthetic phosphopeptide corresponding to amino acid residues surrounding the phospho-Ser549 of synapsin I |
PhosphoSolutions |
100 µl |
416 €
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P1560-603 |
WB In addition to its role in plasticity, the expression of Synapsin I is a precise indicator of synapse formation. Phosphorylation of Ser603 is thought to regulate synaptic vesicle function. Rabbit IgG SR: rat Immunogen: Synthetic phosphopeptide corresponding to amino acid residues surrounding the pSer603 of Synapsin I |
PhosphoSolutions |
100 µl |
416 €
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P1560-6267 |
WB Ser 549 along with Ser 62 and Ser 67 are the sites of synapsin I that are phosphorylated by MAP kinase. Phosphorylation and subsequent dephosphorylation of this site is thought to play a key role in synaptic vesicle trafficking. Rabbit IgG SR: rat Immunogen: synthetic phosphopeptide corresponding to amino acid residues surrounding the phospho-Ser62,67 of synapsin I |
PhosphoSolutions |
100 µl |
416 €
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P1560-9 |
WB Phosphorylation Ser9 is thought to regulate synaptic vesicle function and neurite outgrowth. Rabbit IgG SR: mouse, human, Xenopus Immunogen: Synthetic phosphopeptide corresponding to amino acid residues surrounding the pSer9 of Synapsin I |
PhosphoSolutions |
100 µl |
416 €
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P1570-202 |
WB Phosphorylation may modulate the ability of synaptotagmin to influence both the exocytotic and endocytotic components of synaptic transmission. Rabbit IgG SR: rat, mouse, human Immunogen: Synthetic phosphopeptide corresponding to amino acid residues surrounding the pThr202 of Synaptotagmin |
PhosphoSolutions |
100 µl |
416 €
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P1570-309 |
WB Phosphorylation may modulate the ability of synaptotagmin to influence both the exocytotic and endocytotic components of synaptic transmission. Rabbit IgG SR: rat, mouse, human Immunogen: Synthetic phosphopeptide corresponding to amino acid residues surrounding the pSer309 of Synaptotagmin |
PhosphoSolutions |
100 µl |
416 €
|
|
P1571-129 |
WB Recent evidence suggests that phosphorylation of alpha-synuclein at Ser129 plays a role in the formation of inclusions in Parkinsons disease. Rabbit IgG SR: rat Immunogen: synthetic phosphopeptide corresponding to amino acid residues surrounding the phospho-Ser129 of alpha synuclein |
PhosphoSolutions |
100 µl |
416 €
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P1575-19 |
WB CaM K II phosphorylates Ser19 which lies within the regulatory domain of TPH2. Rabbit IgG SR: rat Immunogen: synthetic phosphopeptide corresponding to amino acid residues surrounding the phospho-Ser19 of rat tryptophan hydroxylase-2 (TPH2) |
PhosphoSolutions |
100 µl |
416 €
|
|
P1575-260 |
WB The activity of TPH is enhanced by phosphorylation by cAMP-dependent protein kinase (PKA) and Ca2+/calmodulin kinase II. Rabbit IgG SR: rat, human Immunogen: synthetic phosphopeptide corresponding to amino acid residues surrounding the phospho-Ser260 of rat tryptophan hydroxylase (TPH) |
PhosphoSolutions |
100 µl |
416 €
|
|
P1575-58 |
WB The activity of TPH is enhanced by phosphorylation by cAMP-dependent protein kinase (PKA) and Ca2+/calmodulin kinase II. Rabbit IgG SR: rabbit Immunogen: synthetic phosphopeptide corresponding to amino acid residues surrounding the phospho-Ser58 of tryptophan hydroxylase (TPH) |
PhosphoSolutions |
100 µl |
416 €
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P1580-19 |
WB, IF, IHC The activity of TH is regulated by phosphorylation. Rabbit IgG SR: rat Immunogen: Synthetic phosphopeptide corresponding to amino acid residues surrounding the pSer19 of rat Tyrosine Hydroxylase |
PhosphoSolutions |
100 µl |
416 €
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P1580-31 |
WB, IF, IHC The activity of TH is regulated by phosphorylation. Rabbit IgG SR: rat, mouse Immunogen: Synthetic phosphopeptide corresponding to amino acid residues surrounding the pSer31 of rat Tyrosine Hydroxylase |
PhosphoSolutions |
100 µl |
416 €
|
|
P1580-40 |
WB, IF, IHC The activity of TH is regulated by phosphorylation. Rabbit IgG SR: mouse, human, monkey, swine, quail Immunogen: Synthetic phosphopeptide corresponding to amino acid residues surrounding the pSer40 of rat Tyrosine Hydroxylase |
PhosphoSolutions |
100 µl |
416 €
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P160-2024 |
WB The activity of this kinase is regulated by dual phosphorylation at Thr202 and Tyr204. Rabbit IgG SR: rat, mouse, human, Xenopus Immunogen: Synthetic phosphopeptide corresponding to amino acid residues surrounding the pThr202 and Tyr204 of rat ERK/MAPK |
PhosphoSolutions |
100 µl |
416 €
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P170-5359 |
WB Down regulation of this receptor plays a key role in determining the magnitude and duration of cytokine signaling. This down regulation is thought to be influenced by phosphorylation of Serine 535 and 539 in the IFNAR1. Rabbit IgG SR: rat Immunogen: synthetic phosphopeptide corresponding to amino acid residues surrounding the phospho-Ser535,539 of human Interferon alpha receptor, type I, subunit I |
PhosphoSolutions |
100 µl |
416 €
|
|
p175-523 |
WB Recent work has demonstrated that the activity of 5-LO is regulated by PKA phosphorylation of serine-523 in 5-LO. Under normal conditions, this phosphorylation may be important in limiting inflammation. MW: 80 kD Rabbit IgG SR: rat, human Immunogen: synthetic phosphopeptide corresponding to amino acid residues surrounding the phospho-Ser523 of human 5-lipoxygenase (5-LO) |
PhosphoSolutions |
100 µl |
416 €
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|
P180-21822 |
WB Activated MEK 1 acts as a dual specificity kinase phosphorylating both a threonine and a tyrosine residue on MAP kinase. Rabbit IgG SR: rat, mouse, human, Xenopus Immunogen: Synthetic phosphopeptide corresponding to amino acid residues surrounding the pSer218,222 of human MEK 1/2 |
PhosphoSolutions |
100 µl |
416 €
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P180-292 |
WB Activated MEK 1 acts as a dual specificity kinase phosphorylating both a threonine and a tyrosine residue on MAP kinase. Rabbit IgG SR: rat Immunogen: Synthetic phosphopeptide corresponding to amino acid residues surrounding the pThr292 of human MEK 1 |
PhosphoSolutions |
100 µl |
416 €
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P183-3115 |
WB MEK5 (also known as MKK5) is a dual specificity serine/threonine protein kinase belonging to the MAP kinase kinase family. Dual phosphorylation of Ser311 and Thr315 have been implicated in cell proliferation. Rabbit IgG SR: rat Immunogen: synthetic phosphopeptide corresponding to amino acid residues surrounding the phospho-Ser311, Thr315 of MEK5 |
PhosphoSolutions |
100 µl |
416 €
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P187-402 |
WB PAK-3 is thought to play a key role in regulation of cell shape and motility as well as cell death. Autophosphorylation of Thr402 in the protein has been found to be essential for activation of PAK. Rabbit IgG SR: rat Immunogen: synthetic phosphopeptide corresponding to amino acid residues surrounding the phospho-Thr402 of rat p21 Activated Kinase 2 (PAK-2) |
PhosphoSolutions |
100 µl |
416 €
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P190-1802 |
WB Like the other MAPKs, p38 is activated by a dual specificity kinase that phosphorylates Thr180 and Tyr182. Rabbit IgG SR: rat, mouse, human Immunogen: Synthetic peptide corresponding to amino acids surrounding pThr180 and pTyr182 of rat p38 MAPK |
PhosphoSolutions |
100 µl |
416 €
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|
P195-392 |
WB Phosphorylation of Ser392 in p53 is associated with formation of human tumors. An increase in p53 has also been linked to deficits in LTP and learning and memory Rabbit IgG SR: mouse, human, monkey Immunogen: Synthetic phosphopeptide corresponding to amino acid residues surrounding the pSer392 of human p53 |
PhosphoSolutions |
100 µl |
416 €
|
|
P197-101 |
WB Recent evidence suggests that phosphorylation of parkin at Ser101 may have an important regulatory role on its E3 ubiquitin ligase activity. Rabbit IgG SR: human Immunogen: synthetic phosphopeptide corresponding to amino acid residues surrounding the phospho-Ser101 of human parkin |
PhosphoSolutions |
100 µl |
416 €
|
|
P197-378 |
WB Recent evidence suggests that phosphorylation of parkin at Ser378 may have an important regulatory role on its E3 ubiquitin ligase activity. Rabbit IgG SR: human Immunogen: synthetic phosphopeptide corresponding to amino acid residues surrounding the phospho-Ser378 of human parkin |
PhosphoSolutions |
100 µl |
416 €
|
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P200-48260 |
WB Considerable evidence indicates that a polo-like kinase (PLK) plays an important role in cell cycle regulation. Activation of PLK is thought to involve a kinase cascade involving the phosphorylation of Ser482,486,490 in PLKK. Rabbit IgG SR: Xenopus Immunogen: synthetic phosphopeptide corresponding to amino acid residues surrounding the phospho-Ser482,486,490 of Xenopus Polo-like Kinase Kinase (PLKK) |
PhosphoSolutions |
100 µl |
416 €
|
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P202-210 |
WB Polo-like kinase (PLK) plays an important role in cell cycle regulation. It has been proposed that PLK1 function is altered at different stages of mitosis through consecutive phosphorylation events at Ser137 and Thr210. Rabbit IgG SR: rat, mouse, human, Xenopus, bovine, Non-human primate, Zebra fish, canine Immunogen: synthetic phosphopeptide corresponding to amino acid residues surrounding the phospho-Thr210 of PLK1 |
PhosphoSolutions |
100 µl |
416 €
|
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P205-190 |
WB Phosphorylation of Ser190 and Ser294 may differentially affect the transcriptional activity of the receptor. Mouse IgG1 SR: human Immunogen: Synthetic phosphopeptide corresponding to amino acid residues surrounding the pSer190 of human Progesterone Receptor |
PhosphoSolutions |
100 µl |
416 €
|
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P205-294 |
WB Phosphorylation of Ser190 and Ser294 may differentially affect the transcriptional activity of the receptor. Mouse SR: human Immunogen: Synthetic phosphopeptide corresponding to amino acid residues surrounding the pSer294 of human Progesterone Receptor |
PhosphoSolutions |
100 µl |
416 €
|
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P275-181 |
WB Autophosphorylation of TAO may play a role in the mechanism of TAO activation. The MEK binding domain of TAO is autophosphorylated on both serine and threonine residues and Ser181 is located within this domain. Rabbit IgG SR: human, mouse, rat Immunogen: synthetic phosphopeptide corresponding to amino acid residues surrounding the phospho-Ser181 of TAO2 |
PhosphoSolutions |
100 µl |
416 €
|
Warenkorb
