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IMG-124A
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ELISA, IF / ICC, IHC  ( frozen ) , IP, WB Erklärungen der Abkürzungen ansehen.
Mouse IgG1 kappa SR: human, mouse, muntjac (deer), rat
Immunogen: Baculovirus expressed His-tagged full length TRF2 protein
Imgenex
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100 µg

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337 €


IMG-417D
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ICC, IF, FC  ( CS, IC )  Erklärungen der Abkürzungen ansehen.
Mouse IgG2a kappa SR: human
Immunogen: Ba/F3 cell line expressing human TLR4 cell surface antigen
Imgenex
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100 µg

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395 €


IMG-561
related products

WB Erklärungen der Abkürzungen ansehen.
Mouse IgG SR: human, monkey
Immunogen: synthetic peptide corresponding to amino acids 207-221 of human androgen receptor, containing the Ser213 phosphorylation site
Imgenex
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100 µg

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337 €

IMG-5341A
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WB Erklärungen der Abkürzungen ansehen.
Rabbit IgG SR: human, mouse
Immunogen: synthetic peptide corresponding to amino acids 560-576 of human MSH2 protein
Imgenex
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100 µg

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302 €

IMG-382
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WB Erklärungen der Abkürzungen ansehen.
Mouse IgG1 kappa SR: human
Immunogen: synthetic peptide of human MLH-1
Imgenex
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100 µg

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302 €

IMG-514
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WB Erklärungen der Abkürzungen ansehen.
Rabbit IgG SR: human
Immunogen: synthetic peptide corresponding to amino acids 249-266 of human Lamin A/C
Imgenex
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100 µg

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302 €

IMG-6803A
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WB Erklärungen der Abkürzungen ansehen.
SIRT1 is a nuclear protein and member of the sirtuin protein family of deacetylating proteins. SIRT1 is involved in regulating a number of cellular pathways including apoptosis and cell senescence, longevity and aging. Not surprisingly, SIRT1 targets to forkhead (FOXO) transcription factors. SIRT1 physically binds to the p65/RelA protein in the NF-kappaB complex and inhibits the transcriptional activity by deacetylating the p65 component. SIRT1 anti-inflammatory responses have also been demonstrated using resveratrol, a potent activator of SIRT1, which has been shown to potentiate the SIRT1-mediated anti-inflammatory response.

Rabbit IgG SR: cat, chicken, chimpanzee, chinese hamster, cow, dog, frog, horse, human, monkey, mouse, orangutan, pig, rabbit
Immunogen: portion of amino acids 400-450 from human SIRT1
Imgenex
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100 µg

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302 €

IMG-395
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IHC, WB Erklärungen der Abkürzungen ansehen.
Mouse IgG1 SR: human, mouse
Immunogen: synthetic peptide corresponding to the caspase-3-induced cleavage site of human Rb
Imgenex
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100 µg

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337 €

IMG-551
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WB Erklärungen der Abkürzungen ansehen.
Rabbit IgG SR: dog, horse, human, mouse, rat
Immunogen: synthetic peptide corresponding to amino acids 251-268 of human Rb
Imgenex
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200 µl

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302 €

IMG-187A
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WB, IP Erklärungen der Abkürzungen ansehen.
Akt1/PKBa is a serine/threonine protein kinase whose kinase activity plays a key role in cellular functions such as apoptosis, glycogen synthesis, and cell growth. Moreover, it plays a role in glucose transport by mediating insulin-induced translocation of the GLUT4 glucose transporter to the cell surface. It promotes glycogen synthesis by mediating the insulin-induced activation of glycogen synthase. Akt1/PKBa is activated by various growth factors such as platelet-derived growth factor (PDGF), epidermal growth factor (EGF), and insulin and insulin-like growth factor I (IGF-I). Defects in Akt1 are associated with breast, colorectal, and ovarian cancer. AKT phosphorylation is critical for its activity. The major phospho sites required for AKT activation have been identified as threonine 308 and serine 473. Serine 473 is phosphorylated by MAPKAP kinase 2.

Mouse IgG1 kappa SR: human, mouse
Immunogen: synthetic peptide containing phosphorylated Ser473 of human Akt1 The sequence in this region is identical in human, mouse, chicken, and frog
Imgenex
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100 µg

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337 €

IMG-187E
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WB, IP Erklärungen der Abkürzungen ansehen.
Akt1/PKBa is a serine/threonine protein kinase whose kinase activity plays a key role in cellular functions such as apoptosis, glycogen synthesis, and cell growth. Moreover, it plays a role in glucose transport by mediating insulin-induced translocation of the GLUT4 glucose transporter to the cell surface. It promotes glycogen synthesis by mediating the insulin-induced activation of glycogen synthase. Akt1/PKBa is activated by various growth factors such as platelet-derived growth factor (PDGF), epidermal growth factor (EGF), and insulin and insulin-like growth factor I (IGF-I). Defects in Akt1 are associated with breast, colorectal, and ovarian cancer. AKT phosphorylation is critical for its activity. The major phospho sites required for AKT activation have been identified as threonine 308 and serine 473. Serine 473 is phosphorylated by MAPKAP kinase 2.

Mouse IgG1 kappa SR: human, mouse
Immunogen: synthetic peptide containing phosphorylated Ser473 of human Akt1 The sequence in this region is identical in human, mouse, chicken, and frog
Imgenex
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100 µg

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348 €

IMG-487
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WB Erklärungen der Abkürzungen ansehen.
Rabbit IgG SR: human
Immunogen: synthetic peptide corresponding to amino acids 464-477 of human Akt1. This peptide sequence is identical in human, mouse, chicken and frog. formerly IMG-307
Imgenex
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200 µl

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302 €

IMG-5297A
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WB Erklärungen der Abkürzungen ansehen.
Rabbit Ig SR: bovine, dog, human, monkey, mouse, pig, rat, rhesus monkey
Immunogen: synthetic peptide 140 - 153
Imgenex
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200 µl

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302 €

IMG-590
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WB Erklärungen der Abkürzungen ansehen.
Rabbit IgG SR: human
Immunogen: synthetic peptide corresponding to amino acids 324-339 of human MAPK14
Imgenex
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200 µl

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302 €

IMG-2000
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Inhibitory peptide, human IKKgamma (NEMO) binding peptide, includes control
NF-​kappaB inhibition Erklärungen der Abkürzungen ansehen.
This cell permeable IKKgamma (NEMO) binding peptide prevents formation of IKK complex formation, thereby inhibiting NF-kB activation.
Imgenex
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2 mg

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500 €

IMG-287A
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WB Erklärungen der Abkürzungen ansehen.
Mouse IgG1 SR: human
Imgenex
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100 µg

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302 €

IMG-324A
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WB Erklärungen der Abkürzungen ansehen.
Mouse IgG1 SR: human, mouse
Immunogen: His-tagged full length human IKK3/IKKg protein
Imgenex
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100 µg

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302 €

IMG-324B
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ELISA, WB Erklärungen der Abkürzungen ansehen.
Mouse IgG1 kappa SR: human, mouse
Immunogen: His-tagged full length human IKK3/IKKg protein
Imgenex
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100 µg

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348 €

IMG-162
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WB Erklärungen der Abkürzungen ansehen.
Mouse IgG SR: human
Immunogen: fusion protein corresponding to amino acids 205 to 222 of human TRAF2
Imgenex
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100 µg

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337 €

IMG-5759
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IHC  ( frozen ) , IHC  ( paraffin ) , IP, WB Erklärungen der Abkürzungen ansehen.
Rabbit SR: human, mouse, rat
Immunogen: synthetic peptide
Imgenex
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50 µl

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267 €

IMG-5760
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IHC  ( frozen ) , IHC  ( paraffin ) , IP, WB Erklärungen der Abkürzungen ansehen.
Rabbit SR: human
Immunogen: synthetic peptide
Imgenex
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50 µl

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267 €

IMG-337
related products

WB Erklärungen der Abkürzungen ansehen.
Rabbit IgG SR: human
Immunogen: synthetic peptides corresponding to amino acids 1-5, 433-448 and 467-482 of human HDAC1
Imgenex
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100 µg

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302 €

IMG-6857A
WB, IHC Erklärungen der Abkürzungen ansehen.
SGK1, an acronym for serum and glucocorticoid regulated kinase, appears to be important for intrauterine embryo implantation and pregnancy maintenance along with a variety of other pathways such as neuronal excitation, renal sodium ion secretion, apoptosis and T-cell signaling.

Rabbit IgG SR: broad
Immunogen: A portion of amino acids 360-410 from human SGK1
Imgenex
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100 µg

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302 €

IMG-336A
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WB Erklärungen der Abkürzungen ansehen.
Mouse IgG1 SR: human
Imgenex
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100 µg

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302 €

IMG-336E
WB Erklärungen der Abkürzungen ansehen.
Chk2 (checkpoint kinase 2) is the mammalian homolog of the Saccharomyces cerevisiae Rad53 and is required for the DNA damage and replication checkpoints. In response to low-dose ionizing radiation (IR), which occurs in an ataxia telangiectasia mutated (ATM)-dependent manner, Chk2 can phosphorylate the mitosis-inducing phosphatase Cdc25C on an inhibitory site, blocking entry into mitosis, and p53 on a regulatory site, causing G1 arrest. In human tissues, Chk2 is homogeneously expressed in renewing cell populations such as epidermis or intestine, heterogeneous in conditionally renewing tissues, and absent or at low level in static tissues such as muscle or brain. Mutations in Chk2 inactivates DNA damage checkpoint pathway involving Chk2 in lung cancer suggesting that reduced expression of Chk2 may be responsible for the development of lung cancer. The Chk2-/- knockout cells are resistant to DNA damage-induced apoptosis, defective for p53 stabilization and for induction of p53-dependent transcripts such as p21 in response to gamma irradiation.

Mouse IgG1 SR: human
Immunogen: A portion of amino acids 100-150 of human Chk2 protein
Imgenex
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100 µg

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337 €

IMG-150A
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FC  ( Intracellular ) , IHC  ( paraffin ) , WB Erklärungen der Abkürzungen ansehen.
Mouse IgG1 kappa SR: human, mouse, rat
Immunogen: synthetic peptide corresponding to amino acids 526-539 of human NF-kB (p65) protein
Imgenex
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100 µg

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337 €

IMG-150B
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WB Erklärungen der Abkürzungen ansehen.
Mouse IgG1 kappa SR: human, mouse, rat
Immunogen: synthetic peptide corresponding to amino acids 526-539 of human NF-kB (p65) protein
Imgenex
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100 µg

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348 €

IMG-150E
Flow ( I ) , IHC ( paraffin ) , WB Erklärungen der Abkürzungen ansehen.
Protein function: NF-kappa-B is a pleiotropic transcription factor present in almost all cell types and is the endpoint of a series of signal transduction events that are initiated by a vast array of stimuli related to many biological processes such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52 and the heterodimeric p65-p50 complex appears to be most abundant one. [The Uniprot Consortium]

Mouse IgG1 kappa SR: human, mouse, rat
Immunogen: Synthetic peptide corresponding to amino acids 526-539 of human NF-kB (p65) protein
Imgenex
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100 µg

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337 €

IMG-2001
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NFkappaB p65 Inhibitory Peptide Set, PTD-​p65 peptide (Ser276), includes control
NF-​kappaB inhibition Erklärungen der Abkürzungen ansehen.
The PTD-p65 peptide can suppress NF-kB activation induced by a variety of inflammatory stimuli and NF-kB-mediated gene transcription and enhanced apoptosis induced by TNF and other apoptotic stimuli.
Imgenex
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2 mg

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500 €

IMG-2003 NFkappaB p65 (Ser529/Ser536) Inhibitory Peptide Set, includes control
NF-​kappaB inhibition Erklärungen der Abkürzungen ansehen.
Functions as a p65 decoy through phosphorylation of Ser529/536 sites on the peptide.
Imgenex
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2 mg

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500 €

IMG-512
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WB Erklärungen der Abkürzungen ansehen.
Rabbit IgG SR: human, mouse, rat
Immunogen: synthetic peptide corresponding to amino acids 538-546 of human p65 (NF-kappaB subunit p65)
Imgenex
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100 µg

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302 €

IMG-5915A
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WB Erklärungen der Abkürzungen ansehen.
Rabbit IgG SR: chimpanzee, human, monkey
Immunogen: synthetic peptide
Imgenex
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100 µg

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302 €

IMG-6066A
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WB Erklärungen der Abkürzungen ansehen.
Rabbit Ig SR: bovine, chimpanzee, gorilla, horse, human, monkey, mouse
Immunogen: synthetic peptide
Imgenex
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100 µg

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302 €

IMG-297A
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WB Erklärungen der Abkürzungen ansehen.
Rabbit IgG SR: human
Imgenex
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100 µg

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302 €

IMG-5023
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WB Erklärungen der Abkürzungen ansehen.
Rabbit IgG SR: human
Immunogen: synthetic peptide corresponding to amino acids 2-16 & 157-170
Imgenex
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100 µg

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302 €

IMG-5347A
related products

WB Erklärungen der Abkürzungen ansehen.
Rabbit IgG SR: human, mouse, rat
Immunogen: synthetic peptide corresponding to amino acids 110-124 of human AIK1
Imgenex
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100 µg

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302 €

IMG-5848A
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WB Erklärungen der Abkürzungen ansehen.
Rabbit IgG SR: bovine, dog, human, mouse, pig, rat, rhesus monkey
Immunogen: synthetic peptide
Imgenex
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100 µg

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302 €

IMG-536
related products

WB Erklärungen der Abkürzungen ansehen.
Rabbit IgG SR: human, mouse
Immunogen: synthetic peptide corresponding to amino acids 436-449 of human TRAF6. TRAF6 = Tumor Necrosis factor (TNF) associated Factor 6
Imgenex
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200 µl

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302 €

IMG-5766
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IHC  ( frozen ) , IHC  ( paraffin ) , IP, WB Erklärungen der Abkürzungen ansehen.
Rabbit SR: cow, human, mouse, rat
Immunogen: synthetic peptide
Imgenex
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50 µl

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302 €

IMG-129A
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FC  ( Intracellular ) , IP, WB Erklärungen der Abkürzungen ansehen.
Mouse IgG1 SR: human, mouse
Immunogen: full length human IKKbeta recombinant proetein
Imgenex
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100 µg

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337 €

IMG-129AF488
FC ( IC )  Erklärungen der Abkürzungen ansehen.
NF-kB (nuclear factor kB) is sequestered in the cytoplasm by IkB family of inhibitory proteins that mask the nuclear localization signal of NF-kB thereby preventing translocation of NF-kB to the nucleus. External stimuli such as tumor necrosis factor or other cytokines results in phosphorylation and degradation of IkB releasing NF-kB dimers. NF-kB dimer subsequently translocates to the nucleus and activates target genes. Synthesis of IkBa is autoregulated. IkB proteins are phosphorylated by IkB kinase complex consisting of at least three proteins, IKK1/a, IKK2/b, and IKK3/g (3-5). IKK1/a and IKK2/b are phosphorylated by NF-kB-inducing kinase (NIK) and MAP kinase kinase kinase-1 (MEKK1), respectively. Recent studies have shown that IKK2/b, not IKK1/a, is the target proinflammatory stimuli. Targeted disruption of IKK2/b gene in mice also results in extensive liver damage from apotopsis and death as embryo.

Mouse IgG1 SR: human, mouse
Immunogen: full-length human IKKb recombinant protein
Imgenex
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100 µg

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348 €

IMG-159A
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WB, IP Erklärungen der Abkürzungen ansehen.
Mouse IgG1 kappa SR: human, mouse
Immunogen: full length IKKb/IKK2 recombinant protein
Imgenex
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100 µg

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302 €

IMG-159AF488
FC ( IC )  Erklärungen der Abkürzungen ansehen.
NF-kB (nuclear factor kB) is sequestered in the cytoplasm by IkB family of inhibitory proteins that mask the nuclear localization signal of NF-kB thereby preventing translocation of NF-kB to the nucleus. External stimuli such as tumor necrosis factor or other cytokines results in phosphorylation and degradation of IkB releasing NF-kB dimers. NF-kB dimer subsequently translocates to the nucleus and activates target genes. Synthesis of IkBa is autoregulated. IkB proteins are phosphorylated by IkB kinase complex consisting of at least three proteins, IKK1/a, IKK2/b, and IKK3/g (3-5). IKK1/a and IKK2/b are phosphorylated by NF-kB-inducing kinase (NIK) and MAP kinase kinase kinase-1 (MEKK1), respectively. Recent studies have shown that IKK2/b, not IKK1/a, is the target proinflammatory stimuli. Targeted disruption of IKK2/b gene in mice also results in extensive liver damage from apotopsis and death as embryo.

Mouse IgG1 kappa SR: human, mouse
Immunogen: full-length human IKKb/IKK2 recombinant protein
Imgenex
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100 µg

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348 €

IMG-537
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IHC  ( paraffin ) , WB Erklärungen der Abkürzungen ansehen.
Rabbit IgG SR: human, mouse, rat
Immunogen: synthetic peptide corresponding to amino acids 328-338 of human CXCR4
Imgenex
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100 µg

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302 €

IMG-537E
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IHC  ( paraffin ) , WB Erklärungen der Abkürzungen ansehen.
Rabbit IgG SR: human, mouse, rat
Imgenex
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100 µg

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302 €

IMG-6325A
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IHC ( paraffin ) , WB Erklärungen der Abkürzungen ansehen.
Beta-arrestin-2, or ARRB2, is an adaptor protein belonging to the arrestin family with an N- arrestin domain and a C- arrestin domain. ARRB2 is a regulatory protein involved in heterotrimeric G protein-coupled receptor desensitization and is known to regulate beta2-adrenergic receptor (beta2AR) function by enhancing beta2AR mediated nuclear translocation of ERK. ARRB2 binds to phosphorylated beta2ARs, thereby causing a significant impairment of their capacity to activate G(S) proteins. Along with AIP4, ARRB2 acts as an endosomal sorting molecule that mediates CXCR4 entry into a degradative pathway. It may also be involved in hormone-specific desensitization of TSH receptors. ARRB2 is a Ca2 binding protein of the retinal outer segments and binds to P-rhodopsin and is also involved in synaptic transmission in photoreceptor cells. It is widely expressed in most of the tissues, especially neuronal tissues and spleen.

Rabbit Ig SR: cow, dog, horse, human, monkey, mouse, rat
Immunogen: a peptide sequence corresponding to amino acids 23-40 of human ARRB2
Imgenex
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100 µg

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302 €

IMX-6097
ELISA Erklärungen der Abkürzungen ansehen.
It is a receptor that binds to peroxisome proliferators such as hypolipidemic drugs and fatty acids and controls the peroxisomal beta-oxidation pathway of fatty acids. It is thus a key regulator of adipocyte differentiation and glucose homeostasis.

Rabbit Ig SR: horse, human, monkey, mouse, rat
Immunogen: synthetic peptide
Imgenex
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100 µl

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220 €

IMG-5006
related products

WB Erklärungen der Abkürzungen ansehen.
Rabbit IgG SR: human
Immunogen: synthetic peptide corresponding to amino acids 366-379of human ERK1
Imgenex
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100 µg

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302 €

IMG-392
related products

WB Erklärungen der Abkürzungen ansehen.
Rabbit IgG SR: human
Immunogen: synthetic peptides corresponding to amino acids 36-52 and 216-232 of human APE
Imgenex
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100 µg

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302 €

IMG-5816A
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WB Erklärungen der Abkürzungen ansehen.
Rabbit IgG SR: bovine, chicken, chimpanzee, dog, human, mouse, rat
Immunogen: synthetic peptide
Imgenex
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100 µg

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302 €

IMG-280
related products

WB Erklärungen der Abkürzungen ansehen.
Rabbit IgG SR: chimpanzee, dog, human, mouse, pig
Immunogen: synthetic peptides of human STAT1
Imgenex
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100 µg

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302 €

IMG-373
related products

WB Erklärungen der Abkürzungen ansehen.
Rabbit IgG SR: human, mouse
Immunogen: synthetic peptide corresponding to amino acids 231-245 of human AML-1 (homologous in AML-1/ETO)
Imgenex
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100 µg

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337 €

IMP-123
hRUNX1 expression Erklärungen der Abkürzungen ansehen.
Mammalian expression vector construct, pCMV/hRUNX1, containing coding sequence of human Runt-related transcription factor 1 (GenBank Accession: BC136381)
Imgenex
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10 µg

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500 €

IMG-6686A
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WB Erklärungen der Abkürzungen ansehen.
RIG-I belongs to the Helicase family and contains two CARD domains, one helicase ATP-binding domain and one helicase C-terminal domain. It is involved in innate immune defense against viruses. It triggers a transduction cascade involving MAVS/IPS1 which leads to activation of NF-kappa-B, IRF3 and IRF7 inducing expression of antiviral cytokines such as INF-beta and RANTES (CCL5) during viral replication. Reports also says that TLR3 and RIG-like receptor on myeloid dendritic cells and Rig-like receptor on human NK cells are both required for production of IFN-gamma in response to double-stranded RNA during viral infection.

Rabbit IgG SR: human, monkey
Immunogen: a portion of amino acid 200-250 of human RIG-I
Imgenex
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100 µg

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302 €

IMG-6705A
IHC, WB Erklärungen der Abkürzungen ansehen.
RIG-I, an RNA helicase of the DEAD/H box family, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), is implicated in a number of cellular processes involving RNA binding and alteration of RNA secondary structure and in innate immune defense against viruses. It acts as a specific sensor for dsRNA, which is absent in uninfected cells but known to be accumulated in virus-infected cells. It contains two CARD domains, one helicase ATP-binding domain and the other helicase C-terminal domain. The CARD domains actually inhibit the activity of RIG-I in normal cell, but once the cell gets infected, RIG I directly binds uncapped 5-prime-triphosphate RNA present in viruses triggering an immune response signal. The signaling cascade involves MAVS/IPS1 which induces the expression of antiviral cytokines such as IFN-beta and RANTES (CCL5) during viral replication through activation of NF-kappa-B, IRF3 and IRF7. The ability of RIG I to sense 5-prime-phosphorylated RNA evolved in the innate immune system as a means of discriminating between self and nonself.

Mouse IgG1 kappa SR: chimpanzee, human, mouse, orangutan, rhesus monkey
Immunogen: synthetic peptide
Imgenex
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100 µg

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302 €

IMG-481
related products

WB Erklärungen der Abkürzungen ansehen.
Mouse IgG1 SR: human
Immunogen: synthetic peptide containing amino acid residues of human lck protein
Imgenex
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100 µg

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302 €

IMG-5664
related products

IHC  ( frozen ) , IHC  ( paraffin ) , IP, WB Erklärungen der Abkürzungen ansehen.
Rabbit SR: human
Immunogen: synthetic peptide
Imgenex
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50 µl

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267 €

IMG-5723
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IHC  ( frozen ) , IHC  ( paraffin ) , IP, WB Erklärungen der Abkürzungen ansehen.
Rabbit IgG SR: cow, dog, human, monkey, rat
Immunogen: synthetic peptide corresponding to amino acids 272-291 of human DAXX
Imgenex
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50 µl

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267 €

IMG-6665A
related products

WB, IHC ( paraffin )  Erklärungen der Abkürzungen ansehen.
Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) catalyzes the reversible oxidative phosphorylation of glyceraldehyde-3-phosphate in the presence of inorganic phosphate and nicotinamide adenine dinucleotide (NAD), an important energy-yielding step in carbohydrate metabolism. Recent evidence suggests that it also is involved in a number of cellular processes such as membrane fusion, phosphotransferase activity, DNA replication and repair, and nuclear RNA export. GAPDH has also been implicated in playing a role in different pathologies such as cancer progression, apoptosis, and neuronal diseases such as Alzheimers and Huntingtons disease. GAPDH is constitutively expressed at high levels in almost all tissues and cell lines making it ideal for use as a loading control marker in immunoblots.

Mouse IgG1 kappa SR: chimpanzee, human, mouse, pig, rhesus monkey
Immunogen: amino acids 279-290 HQVVSSDFNSDT of glyceraldehyde 3-phosphate dehydrogenase protein
Imgenex
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100 µg

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302 €

IMG-401A
related products

FC  ( Intracellular ) , WB Erklärungen der Abkürzungen ansehen.
Mouse IgG SR: human
Imgenex
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100 µg

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337 €

IMG-139A
related products

WB Erklärungen der Abkürzungen ansehen.
Mouse IgG1 kappa SR: cow, dog, human, mouse, rat
Immunogen: synthetic peptide
Imgenex
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100 µg

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337 €

IMG-270A
related products

WB Erklärungen der Abkürzungen ansehen.
This antibody detects both, IKKi/IKke as well as TBK1.

Mouse IgG2a kappa SR: human, mouse, rat
Immunogen: synthetic peptide corresponding to amino acids 175-188 of human IKKi/e protein
Imgenex
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100 µg

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337 €

IMG-6841A
FC, WB Erklärungen der Abkürzungen ansehen.
Toll-like receptors (TLRs) are one of the mechanisms by which the innate immune system senses the invasion of pathogenic microorganisms. TLRs are primary transmembrane proteins of immune cells, they have an extracellular region which contains leucine-rich repeat motifs, and a cytoplasmic tail, which has a Toll/interleukin-1 (IL-1) receptor (TIR) domain. TLRs are pattern recognition receptors (PRRs ) that bind to pathogen-associated molecular patterns (PAMPs). Different TLRs recognize different surface and intracellular components of microorganisms or PAMPS. The interaction between a TLR and a microbial component or PAMP triggers the activation of the innate immune system, as well as the development of acquired immunity. Interaction of PAMPs with different TLRs induces distinct patters of gene expression through signal transduction pathways. TLR signaling occurs through the TIR domains which utilize adaptors such as MyD88, TIRAP, TRIF, and TRAM. NF-kapppa-B and JNK pathways are activated leading to the transcription of genes encoding pro-inflammatory cytokines. TLR-10, originally identified from a spleen cDNA library, is on chromosome 4p14 and has been found to be expressed in lung and in B-lymphocytes. TLR10 is thought to be a potential asthma candidate gene because early life innate immune responses to ubiquitous inhaled allergens and PAMPs may influence asthma susceptibility.

Mouse IgG2b kappa SR: human
Immunogen: Synthetic peptide
Imgenex
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100 µg

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302 €

IMG-424
related products

WB Erklärungen der Abkürzungen ansehen.
Rabbit IgG SR: human, mouse
Immunogen: synthetic peptide corresponding to amino acids 19-35 & 564-579
Imgenex
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100 µg

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302 €

IMG-5770
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IHC  ( frozen ) , IHC  ( paraffin ) , IP, WB Erklärungen der Abkürzungen ansehen.
Rabbit SR: gerbil, human, mouse, rat
Immunogen: recombinant BIR2 domain protein fragment of human XIAP
Imgenex
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50 µl

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302 €

IMG-5771
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IHC  ( frozen ) , IHC  ( paraffin ) , IP, WB Erklärungen der Abkürzungen ansehen.
Rabbit SR: gerbil, human, mouse, rat
Immunogen: recombinant BIR2 domain protein fragment of human XIAP
Imgenex
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50 µl

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267 €

IMG-5772
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IHC  ( frozen ) , IHC  ( paraffin ) , IP, WB Erklärungen der Abkürzungen ansehen.
Rabbit SR: gerbil, human, mouse, rat
Immunogen: recombinant BIR2 domain protein fragment of human XIAP
Imgenex
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50 µl

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267 €

IMG-5773
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IHC  ( frozen ) , IHC  ( paraffin ) , IP, WB Erklärungen der Abkürzungen ansehen.
Rabbit SR: gerbil, human, mouse, rat
Immunogen: recombinant BIR2 domain protein fragment of human XIAP
Imgenex
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50 µl

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267 €

IMG-5774
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IHC  ( frozen ) , IHC  ( paraffin ) , IP, WB Erklärungen der Abkürzungen ansehen.
Rabbit SR: human
Immunogen: synthetic peptide
Imgenex
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50 µl

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267 €

IMG-6799A
WB, FC ( IC )  Erklärungen der Abkürzungen ansehen.
DNA Damage Binding protein 1 (DDB1) binds with CUL4 to form an ubiquitin E3 ligase that targets protein substrates for ubiquitin-dependent proteolysis. Loss of DDB1 impedes the proteolysis of a grouping of CUL4 substrates at least in response to UV and CUL4 ubiquitinylation. DDB1 is highly conserved from yeast to mammals. DDB1 specific antibody probes might be useful in identifying CUL4-DDB1 substrates in epigenetics applications and ubiquitin modification dependent protein function.

Rabbit IgG SR: human, broad
Immunogen: portion of amino acids 385-435 from human DDB1
Imgenex
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100 µg

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302 €

IMG-426
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WB Erklärungen der Abkürzungen ansehen.
Rabbit IgG SR: human
Immunogen: synthetic peptides corresponding to amino acids 31-46 and 94-110 of human TMS1
Imgenex
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100 µg

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302 €

IMG-5662
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IHC  ( frozen ) , IHC  ( paraffin ) , IP, WB Erklärungen der Abkürzungen ansehen.
Rabbit SR: human
Immunogen: synthetic peptide
Imgenex
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50 µl

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302 €

IMG-535
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WB Erklärungen der Abkürzungen ansehen.
Rabbit IgG SR: human, mouse
Immunogen: synthetic peptide corresponding to amino acids 323-340 of human TRAF3
Imgenex
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200 µl

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302 €

IMG-5762
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IHC  ( frozen ) , IHC  ( paraffin ) , IP, WB Erklärungen der Abkürzungen ansehen.
Rabbit SR: human
Immunogen: synthetic peptide
Imgenex
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50 µl

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267 €

IMG-5763
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IHC  ( frozen ) , IHC  ( paraffin ) , IP, WB Erklärungen der Abkürzungen ansehen.
Rabbit SR: gerbil, human, mouse, rat
Immunogen: recombinant protein fragment corresponding to the cytoplasmic end of human TRAF3 (amino acids 341-568)
Imgenex
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50 µl

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267 €

IMG-2004 NFkappaB p50 (NLS) Inhibitory Peptide
p50 decoy', blocking NLS recognition Erklärungen der Abkürzungen ansehen.
Imgenex
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2 mg

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500 €

IMG-5812A
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WB Erklärungen der Abkürzungen ansehen.
Mouse IgG1 kappa SR: human
Immunogen: synthetic peptide
Imgenex
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100 µg

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337 €

IMG-6382A
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WB Erklärungen der Abkürzungen ansehen.
The STAT family is a group of cytoplasmic latent transcription factors that are activated to regulate gene expression in response to a large number of extracellular signaling polypeptides including cytokines, interferons, and growth factors.

Rabbit Ig SR: chimpanzee, dog, human, mouse, rhesus monkey
Immunogen: synthetic peptide
Imgenex
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20 µg

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302 €

IMG-6311A
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IHC ( paraffin ) , WB Erklärungen der Abkürzungen ansehen.
H3.3 constitutes the predominant form of histone H3 in non-dividing cells and is incorporated into chromatin independently of DNA synthesis.

Rabbit IgG SR: chicken, bovine, drosophila, horse, human, mouse, opossum
Immunogen: synthetic peptide
Imgenex
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100 µg

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302 €

IMG-5754
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IHC  ( frozen ) , IHC  ( paraffin ) , IP, WB Erklärungen der Abkürzungen ansehen.
Rabbit SR: gerbil, human, mouse, rat
Immunogen: full-length recombinant human survivin protein
Imgenex
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50 µl

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267 €

IMG-5755
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IHC  ( frozen ) , IHC  ( paraffin ) , IP, WB Erklärungen der Abkürzungen ansehen.
Rabbit SR: gerbil, human, mouse, rat
Immunogen: full-length recombinant human survivin protein
Imgenex
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50 µl

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267 €

IMG-6082A
related products

WB Erklärungen der Abkürzungen ansehen.
Rabbit IgG SR: human
Immunogen: synthetic peptide
Imgenex
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100 µg

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302 €

IMG-5859A
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WB Erklärungen der Abkürzungen ansehen.
BRD4 belongs to the BET family of nuclear proteins that carry 2 bromodomains and an additional ET domain. BRD4 acts at different stages of cell cycle by interacting with proteins including RFC and SPA-1 and regulates cell growth.

Rabbit IgG SR: chimpanzee, human, mouse, rat
Immunogen: synthetic peptide
Imgenex
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100 µg

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302 €

IMG-6425A
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WB Erklärungen der Abkürzungen ansehen.
HSP27, also known as Heat shock 27 kDa protein, is a cytoplasmic protein in interphase cells and colocalizes with mitotic spindles in mitotic cells. It translocates to the nucleus during heat shock.

Rabbit Ig SR: chimpanzee, dog, horse, human, macaque
Immunogen: synthetic peptide
Imgenex
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20 µg

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267 €

IMG-6426A
related products

WB Erklärungen der Abkürzungen ansehen.
HSP27, also known as Heat shock 27 kDa protein, is a cytoplasmic protein in interphase cells and colocalizes with mitotic spindles in mitotic cells. It translocates to the nucleus during heat shock.

Rabbit Ig SR: chimpanzee, dog, horse, human, macaque
Immunogen: synthetic peptide
Imgenex
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100 µg

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302 €

IMG-6428A
related products

WB Erklärungen der Abkürzungen ansehen.
Beta-arrestin 1 is a 418 amino acid containing signaling neurotransmitter that belongs to the arrestin family with an arrestin N terminal and an arrestin C terminal domain.

Rabbit IgG SR: bovine, human, mouse, rat, zebrafish
Immunogen: synthetic peptide
Imgenex
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100 µg

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302 €

IMG-360
related products

WB Erklärungen der Abkürzungen ansehen.
Rabbit IgG SR: human
Immunogen: synthetic peptide containing amino acids 41-56 of human Histone H4
Imgenex
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100 µg

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302 €

IMG-6530A
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IHC ( paraffin ) , WB Erklärungen der Abkürzungen ansehen.
14-3-3 zeta is a 245 amino acid containing protein belonging to the 14-3-3 family mediating signal transduction by binding to phosphoserine containing proteins. It is a highly conserved protein in both plants and mammals. The encoded protein interacts with IRS1 implicating a plausible role in regulating insulin sensitivity. There are several transcript variants, with seven known mammalian isoforms: alpha, beta, gamma, delta, epsilon, zeta and eta. 14-3-3 proteins function in broad regulation of proteins by cytoplasmic sequestration, occupation of interaction domains and import/export sequences, prevention of degradation, and activation/repression of enzyme activity. The protein is highly abundant in brain.

Rabbit IgG SR: chimpanzee, cow, dog, human, mouse, opossum, pig
Immunogen: portion of amino acids 50-100 of human 14-3-3 zeta
Imgenex
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100 µg

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302 €

IMG-6531A
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WB Erklärungen der Abkürzungen ansehen.
14-3-3 zeta is a 245 amino acid containing protein belonging to the 14-3-3 family mediating signal transduction by binding to phosphoserine containing proteins. It is a highly conserved protein in both plants and mammals. The encoded protein interacts with IRS1 implicating a plausible role in regulating insulin sensitivity. There are several transcript variants, with seven known mammalian isoforms: alpha, beta, gamma, delta, epsilon, zeta and eta. 14-3-3 proteins function in broad regulation of proteins by cytoplasmic sequestration, occupation of interaction domains and import/export sequences, prevention of degradation, and activation/repression of enzyme activity. The protein is highly abundant in brain.

Rabbit IgG SR: chimpanzee, cow, dog, human, mouse, rat, rhesus monkey
Immunogen: portion of amino acids 200-245 of human 14-3-3 zeta
Imgenex
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100 µg

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302 €

IMG-5747
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IHC  ( frozen ) , IHC  ( paraffin ) , IP, WB Erklärungen der Abkürzungen ansehen.
Rabbit SR: human
Immunogen: synthetic peptide
Imgenex
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50 µl

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267 €

IMG-6072A
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WB Erklärungen der Abkürzungen ansehen.
Rabbit IgG SR: human
Immunogen: synthetic peptide
Imgenex
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100 µg

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302 €

IMG-5346A
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WB Erklärungen der Abkürzungen ansehen.
Nogo A = 1192 AA (human) and 1162 (mouse), Nogo B1 = 373 AA (human) and 375 (mouse)

Rabbit IgG SR: mouse, human, rat
Immunogen: a portion of amino acids 1-50 of human Nogo-B was used as the immunogen
Imgenex
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200 µl

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337 €

IMG-6798A
WB, FC ( IC )  Erklärungen der Abkürzungen ansehen.
VPRBP binds and bridges the CUL4 and DDB1 ubiquitin ligase complex, binding the DNA damage binding protein DDB1 and CUL4. VPRBP is the acronym for the human immunodeficiency virus type-1 Vpr binding protein. CUL4 is a cullin family memember. Cullins are ubiquitin ligases that are cable of ubiquitinylating a wide range of protein substrates. All ubiquitin ligases are important as the modification of proteins by ubiquitin addition modifies or activates functionality. VPRBP is critical for normal cell cycle progression through S phase and allows proper cell proliferation and development. VPRBP appears to serve in an epigenetic role through regulation of histone methylation. VPRBP antibody provides a reagent for exploration of ubiqitin ligase activities in cell cycle and other cell pathways responsible for normal cell growth and function.

Rabbit IgG SR: human, broad
Immunogen: portion of amino acids 935-985 from human VPRBP
Imgenex
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100 µg

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302 €

IMG-5876A
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WB Erklärungen der Abkürzungen ansehen.
Rabbit IgG SR: chimpanzee, cow, dog, human
Immunogen: synthetic peptide
Imgenex
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100 µg

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302 €

IMG-6897A
WB Erklärungen der Abkürzungen ansehen.
Matrix metallopeptidase 2 (also known as MMP2, gelatinase A, 72kDa gelatinase, and 72kDa type IV collagenase) belongs to a family of mammalian extracellular neutral metalloproteinases that are able to degrade a number of matrix proteins. MMP-2 degrades type IV collagen, the structural component of basement membranes, in a specific manner, and it also has gelatinase activity. The protein also plays a role in endometrial menstrual breakdown, regulation of vascularization and the inflammatory response. The pathological role of the protein has been observed in multicentric osteolysis nodulosis and arthropathy and Winchester syndrome.

Rabbit IgG SR: cat, chimpanzee, dog, horse, human, orangutan
Immunogen: A portion of amino acids 550-600 of human MMP2
Imgenex
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100 µg

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302 €

IMG-261A
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ChIP, IHC  ( paraffin ) , WB Erklärungen der Abkürzungen ansehen.
Mouse IgG1 kappa SR: human, mouse, zebrafish
Immunogen: synthetic peptide corresponding to amino acids 637-651 of human Dnmt1
Imgenex
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100 µg

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337 €

IMG-5746
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IHC  ( frozen ) , IHC  ( paraffin ) , IP, WB Erklärungen der Abkürzungen ansehen.
Rabbit SR: dog, human, mouse, rat
Immunogen: synthetic peptide
Imgenex
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50 µl

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267 €

IMG-575
related products

WB Erklärungen der Abkürzungen ansehen.
Rabbit IgG SR: human
Immunogen: synthetic peptide corresponding to amino acids 372-390 of human MST-1
Imgenex
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100 µg

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302 €

IMG-552
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WB Erklärungen der Abkürzungen ansehen.
Rabbit IgG SR: human
Immunogen: synthetic peptide corresponding to amino acids 871-888 of human NFBD1
Imgenex
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200 µl

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302 €

IMG-6313A
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IHC ( paraffin ) , WB Erklärungen der Abkürzungen ansehen.
TIP60 is a catalytic subunit of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes. TIP60 has a role in DNA repair and apoptosis and is thought to play an important role in signal transduction.

Rabbit IgG
Immunogen: synthetic peptide corresponding to amino acids 499-512
Imgenex
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100 µg

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302 €

IMG-6262A
related products

WB Erklärungen der Abkürzungen ansehen.
Laforin plays an important role in the regulation of glycogen metabolism, prevents the formation of polyglucasans, and hydrolyze phosphotyrosine and phosphoserine/threonine substrates.

Rabbit Ig SR: cow, human
Immunogen: synthetic peptide
Imgenex
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100 µg

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302 €

IMG-6009A
related products

WB Erklärungen der Abkürzungen ansehen.
Rabbit Ig SR: cow, dog, horse, human, monkey
Immunogen: synthetic peptide
Imgenex
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100 µg

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302 €

IMG-5988A
related products

WB Erklärungen der Abkürzungen ansehen.
Rabbit IgG SR: human
Immunogen: synthetic peptide
Imgenex
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100 µg

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302 €

IMG-6063A
related products

WB Erklärungen der Abkürzungen ansehen.
This enzyme metabolizes procarcinogens such as polycyclic aromatic hydrocarbons and 17beta-estradiol and is also involved in the metabolism of substances active in the eye growth and differentiation.

Rabbit IgG SR: chimpanzee, human, monkey
Immunogen: synthetic peptide
Imgenex
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100 µg

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302 €

IMG-348
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WB Erklärungen der Abkürzungen ansehen.
Mouse IgG1 SR: human
Immunogen: synthetic peptide of human p63
Imgenex
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100 µg

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302 €

IMG-127A
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WB, IP Erklärungen der Abkürzungen ansehen.
Mouse IgG1 kappa SR: human, mouse
Immunogen: recombinant protein corresponding to amino acids 32-391 of human IKBa
Imgenex
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100 µg

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337 €

IMG-127B
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WB, ELISA Erklärungen der Abkürzungen ansehen.
Mouse IgG1 kappa SR: human, mouse
Immunogen: recombinant protein corresponding to amino acids 32-391 of human IKBa
Imgenex
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100 µg

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348 €

IMG-156A
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WB, IP, ELISA Erklärungen der Abkürzungen ansehen.
Mouse IgG1 kappa SR: human, mouse
Immunogen: synthetic peptide containing phosphorylated Ser32 and Ser36 of human IkBa
Imgenex
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100 µg

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337 €

IMG-156B
related products

WB, IP, ELISA Erklärungen der Abkürzungen ansehen.
Mouse IgG1 kappa SR: human, mouse
Immunogen: synthetic peptide containing phosphorylated Ser32 and Ser36 of human IkBa
Imgenex
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100 µg

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348 €

IMG-394
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WB Erklärungen der Abkürzungen ansehen.
Mouse IgG1 SR: human
Immunogen: synthetic peptide corresponding to the caspase-3 med cleavage site
Imgenex
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100 µg

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337 €

IMG-5016
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WB Erklärungen der Abkürzungen ansehen.
Rabbit IgG SR: human
Immunogen: synthetic peptide corresponding to amino acids 34-48 of human IkBalpha
Imgenex
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100 µl

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302 €

IMG-5270A
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WB Erklärungen der Abkürzungen ansehen.
Does not react with mouse I-kappa-B-alpha.

Rabbit IgG SR: human
Immunogen: full length recombinant protein
Imgenex
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100 µg

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302 €

IMG-565
related products

WB Erklärungen der Abkürzungen ansehen.
Rabbit IgG SR: human, monkey, mouse, rat
Immunogen: synthetic peptide corresponding to amino acids 186-199 & 509-523 of human Smad4
Imgenex
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200 µl

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302 €

IMG-505
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WB Erklärungen der Abkürzungen ansehen.
Rabbit IgG SR: human
Immunogen: mixture of synthetic peptides corresponding to human PRMT5 amino acid sequence PRMT = Protein aRginine MethylTransferase JBP = Janus kinase-binding protein
Imgenex
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200 µl

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302 €

IMG-6389A
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WB Erklärungen der Abkürzungen ansehen.
SHIP2, also known as 'phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase 2,' is a cytoplasmic protein that translocates to membrane ruffles when activated, due to different stimulus and cell type.

Rabbit Ig SR: chimpanzee, bovine, dog, horse, human, mouse, rat, rhesus monkey
Immunogen: synthetic peptide
Imgenex
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20 µg

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302 €

IMG-6383A
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WB Erklärungen der Abkürzungen ansehen.
Rabbit Ig SR: chicken, chimpanzee, dog, human, mouse, rat, zebrafish
Immunogen: portion of human Paxillin protein containing a phosphorylated tyrosine at position 118
Imgenex
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100 µl

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302 €

IMG-274A
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WB Erklärungen der Abkürzungen ansehen.
Mouse IgG1 SR: human
Immunogen: synthetic peptide corresponding to amino acids 217-222 of human caspase-8
Imgenex
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100 µg

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337 €

IMG-274B
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WB Erklärungen der Abkürzungen ansehen.
Mouse IgG1 kappa SR: human
Immunogen: synthetic peptide corresponding to amino acids 217-222 of human caspase-8
Imgenex
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100 µg

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302 €

IMG-5703
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IHC  ( frozen ) , IHC  ( paraffin ) , IP, WB Erklärungen der Abkürzungen ansehen.
Rabbit SR: gerbil, human, mouse, rat
Immunogen: recombinant catalytically active human Caspase-8 protein
Imgenex
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50 µl

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302 €

IMG-5704
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IHC  ( frozen ) , IHC  ( paraffin ) , IP, WB Erklärungen der Abkürzungen ansehen.
Rabbit SR: gerbil, human, mouse, rat
Immunogen: synthetic peptide
Imgenex
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50 µl

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267 €

IMG-6391A
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WB Erklärungen der Abkürzungen ansehen.
USP7 (ubiquitin specific peptidase 7) is a nuclear protein belonging to the peptidase C19 family with a MATH domain and is known to cleave ubiquitin fusion protein substrates.

Rabbit IgG SR: chicken, chimpanzee, dog, horse, human, macaque, mouse, rat
Immunogen: synthetic peptide
Imgenex
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100 µg

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302 €

IMG-6392A
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IHC ( paraffin ) , WB Erklärungen der Abkürzungen ansehen.
USP7 (ubiquitin specific peptidase 7) is a nuclear protein belonging to the peptidase C19 family with a MATH domain and is known to cleave ubiquitin fusion protein substrates.

Rabbit IgG SR: chicken, chimpanzee, dog, horse, human, macaque, mouse, rat
Immunogen: synthetic peptide
Imgenex
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100 µg

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302 €

IMG-308
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ChIP, IP, WB Erklärungen der Abkürzungen ansehen.
Rabbit IgG SR: human
Immunogen: synthetic peptide corresponding to amino acids 2-17 of human HDAC3
Imgenex
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100 µg

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337 €

IMG-5757
related products

IHC  ( frozen ) , IHC  ( paraffin ) , IP, WB Erklärungen der Abkürzungen ansehen.
Rabbit SR: human
Immunogen: synthetic peptide
Imgenex
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50 µl

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267 €

IMG-441
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IP, WB Erklärungen der Abkürzungen ansehen.
Rabbit IgG SR: human, mouse
Immunogen: mixture of synthetic peptides containing amino acids 38-54 and 120-136 of mouse IRAK-4
Imgenex
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200 µl

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302 €

IMG-5162A
FC Erklärungen der Abkürzungen ansehen.
Rabbit Ig SR: human
Immunogen: synthetic peptide
Imgenex
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100 µl

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337 €

IMG-136A
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WB, IP Erklärungen der Abkürzungen ansehen.
Mouse IgG1 kappa SR: human, monkey, mouse
Immunogen: His-tagged full length human IKKa/IKK1 protein
Imgenex
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100 µg

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337 €

IMG-136AF488
FC ( IC )  Erklärungen der Abkürzungen ansehen.
NF-kB (nuclear factor kB) is sequestered in the cytoplasm by IkB family of inhibitory proteins that mask the nuclear localization signal of NF-kB thereby preventing translocation of NF-kB to the nucleus. External stimuli such as tumor necrosis factor or other cytokines results in phosphorylation and degradation of IkB releasing NF-kB dimers. NF-kB dimer subsequently translocates to the nucleus and activates target genes. Synthesis of IkBa is autoregulated. IkB proteins are phosphorylated by IkB kinase complex consisting of at least three proteins, IKK1/a, IKK2/b, and IKK3/g. In vitro, IKK1/a and IKK2/b can form homo- and heterodimers that can phosphorylate IkBs at the regulatory serine residues directly. IKK1/a and IKK2/b are phosphorylated by NF-kB-inducing kinase (NIK) and MAP kinase kinase kinase-1 (MEKK1), respectively. Targeted disruption of IKK1/a gene in mice results in skin and limb abnormalities and death of newborns (2,3).

Mouse IgG1 kappa SR: human, monkey, mouse
Immunogen: His-tagged full-length human IKKa/IKK1 protein
Imgenex
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100 µg

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348 €

IMG-6386A
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WB Erklärungen der Abkürzungen ansehen.
Rad17 ('cell cycle checkpoint protein RAD17'), is a nuclear protein belonging to the Rad17/RAD24 family and necessary for sustained cell growth, maintenance of chromosomal stability, and ATR-dependent checkpoint activation upon DNA damage.

Rabbit Ig SR: chimpanzee, human, orangutan, rhesus monkey
Immunogen: synthetic peptide
Imgenex
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20 µg

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302 €

IMG-5822A
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WB Erklärungen der Abkürzungen ansehen.
Rabbit IgG SR: bovine, broad, chicken, chimpanzee, dog, human, monkey
Immunogen: synthetic peptide
Imgenex
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100 µg

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302 €

IMG-5823A
related products

WB Erklärungen der Abkürzungen ansehen.
Rabbit IgG SR: bovine, broad, chimpanzee, dog, human, monkey
Immunogen: synthetic peptide
Imgenex
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100 µg

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302 €

IMG-351
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Mouse IgM SR: human
Immunogen: synthetic peptides of human Akt2
Imgenex
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200 µl

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302 €

IMG-421
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WB Erklärungen der Abkürzungen ansehen.
Rabbit IgG SR: human
Immunogen: synthetic peptides of human Akt2
Imgenex
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200 µl

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302 €

IMG-179
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WB, IP Erklärungen der Abkürzungen ansehen.
Rabbit IgG SR: human, mouse
Immunogen: synthetic peptide corresponding to amino acids 700 to 712 of human IRAK
Imgenex
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100 µg

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302 €

IMG-6562A
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IHC ( paraffin ) , WB Erklärungen der Abkürzungen ansehen.
hnRNPK is most extensively studied among heterogeneous nuclear ribonucleoproteins family, which plays an important role in cell signaling, telomere elongation, DNA repair and regulation of expression at both transcriptional and translational levels. It is a highly conserved RNA/DNA-binding protein which interacts with different classes of factors of extracellular signals.

Rabbit IgG SR: chimpanzee, human, monkey, mouse, opossum, rat
Immunogen: portion of amino acid 1 to 50 of human hnRNPK
Imgenex
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100 µg

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302 €

IMG-6563A
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WB Erklärungen der Abkürzungen ansehen.
hnRNPK is most extensively studied among heterogeneous nuclear ribonucleoprotein families which plays an important role in cell signaling, telomere elongation, DNA repair and regulation of expression at both transcriptional and translational levels. It is a highly conserved RNA/DNA-binding protein which interacts with different classes of factors of extracellular signals.

Rabbit IgG SR: chimpanzee, human, monkey, mouse, opossum, rat
Immunogen: portion of amino acid 200 to 250 of human hnRNPK
Imgenex
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100 µg

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302 €

IMG-6564A
IHC Erklärungen der Abkürzungen ansehen.
hnRNPK is most extensively studied among heterogeneous nuclear ribonucleoprotein families which plays an important role in cell signaling, telomere elongation, DNA repair and regulation of expression at both transcriptional and translational levels. It is a highly conserved RNA/DNA-binding protein which interacts with different classes of factors of extracellular signals.

Rabbit IgG SR: chimpanzee, human, monkey, mouse, opossum, rat
Immunogen: portion of amino acid 380 to 430 of human hnRNPK
Imgenex
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100 µg

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302 €

IMG-6221A
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WB Erklärungen der Abkürzungen ansehen.
Rabbit IgG SR: human
Immunogen: synthetic peptide corresponding to amino acids 228-242 of human MAPRE1
Imgenex
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100 µg

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302 €

IMG-6221E
related products

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EB1 is a microtubule-associated protein that interacts with the colorectal adenomatous polyposis coli tumor-suppressor protein and plays important roles in regulating microtubule dynamics, cell polarity, and chromosome stability.

Rabbit IgG SR: human
Immunogen: synthetic peptide corresponding to amino acids 228-242 of human MAPRE1
Imgenex
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100 µg

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302 €

IMG-326
related products

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Mouse IgG1 SR: human, mouse, rat
Immunogen: synthetic peptide corresponding to amino acids 119-136 of human Akt3
Imgenex
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100 µg

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302 €

IMG-355
related products

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Rabbit IgG SR: human, mouse, rat
Immunogen: synthetic peptide corresponding to amino acids 119-136 of human Akt3
Imgenex
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200 µl

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302 €

IMG-5842A
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Rabbit IgG SR: dog, human, mouse, rat, rhesus monkey, zebrafish
Immunogen: synthetic peptide
Imgenex
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100 µg

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302 €

IMG-5887A
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Rabbit IgG SR: dog, human, mouse, rat, rhesus monkey
Immunogen: synthetic peptide
Imgenex
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100 µg

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302 €

IMG-6033A
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Rabbit IgG SR: chimpanzee, cow, dog, human, monkey, mouse
Immunogen: synthetic peptide
Imgenex
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100 µg

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302 €

IMG-6361A
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LSD1, a novel and first known lysine-specific histone demethylase, nuclear protein belonging to the flavin monoamine oxidase family with a SWIRM domain, a FAD-binding motif, and an amine oxidase domain. LSD1, a component of several histone deacetylase complexes, is ubiquitously expressed in most of the tissues. A component of the CoREST and other transcriptional co-repressor complexes, LSD1 is known to play an important role in silencing neuronal-specific genes in non-neuronal cells. It is also known to demethylate Lys-4 of histone H3, a specific tag for epigenetic transcriptional activation. Reports suggest that it plays an important role in stimulating androgen-receptor-dependent transcription converting oxygen to hydrogen peroxide (possibly using alternative electron acceptors). Along with nuclear FHL2 it serves as a novel biomarker predictive for prostate cancer.

Rabbit IgG SR: chimpanzee, cow, dog, horse, human, mouse, orangutan, pig
Immunogen: a portion of amino acids 450-500 of human LSD1
Imgenex
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100 µg

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302 €

IMG-288
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IF / ICC, WB Erklärungen der Abkürzungen ansehen.
Rabbit IgG SR: human, mouse
Immunogen: synthetic peptide corresponding to amino acids 133-148 of human Rad1
Imgenex
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100 µg

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302 €

IMG-5685
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IHC  ( frozen ) , IHC  ( paraffin ) , IP, WB Erklärungen der Abkürzungen ansehen.
Rabbit SR: cat, dog, human
Immunogen: synthetic peptide
Imgenex
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50 µl

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267 €

IMG-5686
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IHC  ( frozen ) , IHC  ( paraffin ) , IP, WB Erklärungen der Abkürzungen ansehen.
Rabbit SR: cat, dog, human
Immunogen: synthetic peptide
Imgenex
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50 µl

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267 €

IMG-5689
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IHC  ( frozen ) , IHC  ( paraffin ) , IP, WB Erklärungen der Abkürzungen ansehen.
Rabbit SR: human
Immunogen: synthetic peptide
Imgenex
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50 µl

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267 €

IMG-311
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WB Erklärungen der Abkürzungen ansehen.
Rabbit IgG SR: human
Immunogen: synthetic peptide corresponding to amino acids 13-27
Imgenex
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100 µg

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302 €

IMG-350A
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Mouse IgG1 SR: human
Immunogen: synthetic peptide containing phosphorylated Thr71 of human ATF-2
Imgenex
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100 µg

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348 €

IMG-582
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Rabbit IgG SR: human, mouse
Immunogen: synthetic peptide corresponding to amino acids 525-540 of human Bcl-6
Imgenex
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100 µg

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302 €

IMG-6041A
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Rabbit Ig SR: human
Immunogen: synthetic peptide
Imgenex
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100 µl

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302 €

IMG-6187A
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Expression of NDRG1 is markedly upregulated in various cells under such conditions as cell differentiation, hypoxia and exposure to heavy metals. However, its expression is repressed after cellular transformation.

Goat Ig SR: human
Immunogen: synthetic peptide
Imgenex
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100 µg

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302 €

IMG-3202
IHC  ( paraffin )  Erklärungen der Abkürzungen ansehen.
Goat Ig SR: human
Imgenex
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100 µg

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373 €

IMG-5898A
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Rabbit IgG SR: chimpanzee, human, monkey, mouse
Immunogen: synthetic peptide
Imgenex
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100 µg

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302 €

IMG-5903A
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Rabbit IgG SR: dog, human, monkey
Immunogen: synthetic peptide
Imgenex
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100 µg

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302 €

IMG-161A
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IP, WB Erklärungen der Abkürzungen ansehen.
A20/TNFAIP3 is an important negative regulator of proinflammatory signaling pathways, including NF-kappaB signaling. A20 is upregulated through NF-kappaB (p50/p65) activation, and subsequently down regulates NF-kB through its dual function as a deubiquitinase and ubiquitin ligase.

Mouse IgG1 kappa SR: human
Imgenex
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100 µg

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337 €

IMG-6213A
Peptide ELISA Erklärungen der Abkürzungen ansehen.
The 70 kDa ribosomal S6 kinase, p70S6K1, is a serine/threonine kinase that functions as a downstream target of the phosphatidylinositol 3-kinase (PI3K)/AKT and mitogen-activated protein (MAP) kinase signaling pathways. p70S6K1 mediates several effects of the PI3K/AKT pathway, including cellular transformation. The protein is also involved in neuronal cell differentiation, cell cycle progression and promotes the G1 phase of the cell cycle in response to growth factors. The protein has been implicated in inducing actin filament remodeling, an essential process for cell migration. Recent data suggests that the protein regulates the expression of an oncoprotein, HDM2, thus mediating tumor growth. Human p70S6K1 gene is localized in the chromosomal region 17q23.1. The protein is widely expressed and exists in two isoforms: a 70 kDa cytoplasmic form and a 85 kDa nuclear form.

Goat Ig SR: bovine, human, mouse, rabbit, rat
Immunogen: amino acids 512-525 of human p70S6K1
Imgenex
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100 µl

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302 €

IMG-5877A
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Rabbit IgG SR: dog, human, mouse, rat, rhesus monkey
Immunogen: synthetic peptide
Imgenex
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100 µg

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302 €

IMG-5987A
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WB Erklärungen der Abkürzungen ansehen.
Rabbit Ig SR: chicken, chimpanzee, cow, dog, human, monkey, rat
Immunogen: synthetic peptide
Imgenex
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100 µg

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302 €

IMG-6300A
related products

IHC ( paraffin ) , WB Erklärungen der Abkürzungen ansehen.
eIF3B is known to bind to the 40S ribosomal subunit and promotes the binding of methionyl-tRNAi and mRNA. eIF3B is a component of the EIF3 multiprotein complex. Also known to interact with eIF3A and directly with the p170 subunit of EIF3.

Rabbit Ig SR: human, mouse, rhesus monkey
Immunogen: synthetic peptide corresponding to amino acids 3-19
Imgenex
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100 µg

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302 €

IMG-385
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WB, IP Erklärungen der Abkürzungen ansehen.
Rabbit IgG SR: human
Immunogen: synthetic peptides corresponding to amino acids 2-19 and 131-148 of human UBE2N
Imgenex
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100 µg

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302 €

IMG-6133A
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Rabbit Ig SR: chicken, chimpanzee, cow, dog, drosophila, human, mouse, rat
Immunogen: synthetic peptide
Imgenex
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50 µg

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348 €

IMG-6134A
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MEK1 and MEK2 are integral components of the MAP kinase cascade that regulates cell growth and differentiation and this pathway also plays a key role in synaptic plasticity in brain.

Rabbit Ig SR: chicken, chimpanzee, cow, dog, drosophila, human, mouse, rat
Immunogen: synthetic peptide
Imgenex
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100 µg

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302 €

IMG-276
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WB Erklärungen der Abkürzungen ansehen.
Rabbit IgG SR: human
Immunogen: synthetic peptide corresponding to amino acids 3-14 that is common in human and mouse Bcl-XL and Bcl-XS protein
Imgenex
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100 µg

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302 €

IMG-5690
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IHC  ( frozen ) , IHC  ( paraffin ) , IP, WB Erklärungen der Abkürzungen ansehen.
Rabbit SR: dog, gerbil, human, mouse, rat
Immunogen: recombinant human Bcl-XL protein without the N-terminal transmembrane portion
Imgenex
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50 µl

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267 €

IMG-5691
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WB, IHC  ( paraffin ) , IHC  ( frozen ) , IP Erklärungen der Abkürzungen ansehen.
Rabbit SR: human, mouse, rat, gerbil
Immunogen: synthetic peptide
Imgenex
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50 µl

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267 €

IMG-5692
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IHC  ( frozen ) , IHC  ( paraffin ) , IP, WB Erklärungen der Abkürzungen ansehen.
Rabbit SR: gerbil, human, mouse, rat
Immunogen: synthetic peptide
Imgenex
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50 µl

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267 €

IMG-148A
ChIP, IP, WB Erklärungen der Abkürzungen ansehen.
Goat IgG SR: human, mouse
Imgenex
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100 µg

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337 €

IMG-5322A
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WB Erklärungen der Abkürzungen ansehen.
Rabbit Ig SR: mouse, human
Immunogen: synthetic peptide 925-940
Imgenex
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200 µl

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337 €

IMG-164
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IF / ICC, IHC  ( paraffin ) , IP, WB Erklärungen der Abkürzungen ansehen.
Mouse IgG SR: human
Immunogen: GST fusion protein of human full length Rad9
Imgenex
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100 µg

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337 €

IMG-246
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IF / ICC, IP, WB Erklärungen der Abkürzungen ansehen.
Mouse IgG1 kappa SR: human, mouse
Immunogen: full length human p73
Imgenex
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200 µl

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337 €

IMG-259A
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ChIP, IF / ICC, IP, WB Erklärungen der Abkürzungen ansehen.
Mouse IgG1 kappa SR: human, mouse
Imgenex
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200 µl

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337 €

IMG-260
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WB Erklärungen der Abkürzungen ansehen.
Mouse IgG SR: human
Immunogen: full length human p73
Imgenex
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200 µl

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302 €

IMG-313A
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ChIP, IHC  ( paraffin ) , WB Erklärungen der Abkürzungen ansehen.
Mouse IgG1 kappa SR: human, mouse, rat
Immunogen: synthetic peptide
Imgenex
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100 µg

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337 €

IMG-5355A
related products

WB Erklärungen der Abkürzungen ansehen.
p73 was identified as a long-lost cousin of tumor suppressor protein, p53. Homology between p53, p63, and p73 (approximately 63% amino acid identity in the DNA-binding domain) suggests that they may have overlapping functions.

Rabbit IgG SR: human
Immunogen: a portion of amino acids 75-125, containing a phosphorylated tyrosine residue at position 99, of human p73
Imgenex
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20 µg

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348 €

IMG-5356A
related products

WB Erklärungen der Abkürzungen ansehen.
Rabbit Ig SR: human
Immunogen: synthetic peptide
Imgenex
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100 µg

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302 €

IMG-5228A
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WB, IHC Erklärungen der Abkürzungen ansehen.
Rabbit IgG SR: human
Immunogen: synthetic peptide
Imgenex
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100 µg

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302 €

IMG-271A
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WB Erklärungen der Abkürzungen ansehen.
Mouse IgG1 SR: human
Immunogen: synthetic peptide
Imgenex
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100 µg

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302 €

IMG-271B
ELISA Erklärungen der Abkürzungen ansehen.
WB: 2-4 ug/ml

Mouse IgG1 kappa SR: human
Immunogen: synthetic peptide of human CREB
Imgenex
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100 µg

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337 €

IMG-6281A
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RORA binds to the retinoic acid response element and thus regulates gene expression and also controls cell function. It interacts with NM23-2, NM23-1, CDK7, NCOA3 and NCOA6 coactivators.

Rabbit Ig SR: chicken, chimpanzee, bovine, horse, human, monkey, mouse, opossum
Immunogen: synthetic peptide
Imgenex
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100 µg

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302 €

IMG-6282A
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WB Erklärungen der Abkürzungen ansehen.
RORA binds to the retinoic acid response element and thus regulates gene expression and also controls cell function. It interacts with NM23-2, NM23-1, CDK7, NCOA3 and NCOA6 coactivators.

Rabbit Ig SR: chicken, chimpanzee, bovine, dog, horse, human, mouse
Immunogen: synthetic peptide
Imgenex
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100 µg

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302 €

IMG-333
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WB Erklärungen der Abkürzungen ansehen.
Rabbit IgG SR: human
Immunogen: synthetic peptide of human CCR5
Imgenex
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100 µg

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302 €

IMG-369
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WB Erklärungen der Abkürzungen ansehen.
Rabbit IgG SR: human
Immunogen: synthetic peptides corresponding to amino acids 66-81 and 135-151 of human INHAT-1
Imgenex
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200 µl

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302 €

IMG-6010A
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WB Erklärungen der Abkürzungen ansehen.
Rabbit Ig SR: chimpanzee, human
Immunogen: synthetic peptide
Imgenex
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100 µg

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302 €

IMG-5808A
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WB Erklärungen der Abkürzungen ansehen.
Rabbit IgG SR: chimpanzee, human
Immunogen: synthetic peptide
Imgenex
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100 µg

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150 €

IMG-5916A
FA  ( Neutr. ) , FC  ( Cell Surface ) , IHC Erklärungen der Abkürzungen ansehen.
Mouse IgG1 kappa SR: human
Imgenex
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100 µg

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150 €

IMG-5916C
FA  ( Neutr. ) , FC  ( Cell Surface ) , IHC Erklärungen der Abkürzungen ansehen.
Mouse IgG1 kappa SR: human
Imgenex
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100 tests

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220 €

IMG-5916D
FA  ( Neutr. ) , FC  ( Cell Surface ) , IHC Erklärungen der Abkürzungen ansehen.
Mouse IgG1 kappa SR: human
Imgenex
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100 tests

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220 €

IMG-5916E
FA ( Neutralization ) , FC ( CS ) , IHC ( cryosections )  Erklärungen der Abkürzungen ansehen.
CD4 may regulate T-cell activation. It plays a more general role in mediating cell recognition events than merely those of cellular immune response.

Mouse IgG1 kappa SR: human
Imgenex
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100 µg

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115 €

IMG-5916G
FA  ( Neutr. ) , FC  ( Cell Surface ) , IHC Erklärungen der Abkürzungen ansehen.
Mouse IgG1 kappa SR: human
Imgenex
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100 Tests

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220 €

IMG-6351A
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IHC ( paraffin ) , WB Erklärungen der Abkürzungen ansehen.
RAP2A is a signaling protein involved in small GTPase mediated signal transduction activated by guanine nucleotide-exchange factors (GEF) EPAC and EPAC2, in a cAMP-dependent manner, and GFR. This membrane protein belongs to the small GTPase superfamily and Ras family and contains domains required for GTP binding and a Ras-like C-terminal motif for post-translational lipid binding and subsequent anchoring to the plasma membrane. Apart from having a possible role in membrane shedding, RAP2A also functions as a slowly responding molecular switch in the RAP1A signaling cascade and also interacts with ARHGAP29, the putative specific effector of RAP2A.

Rabbit Ig SR: chicken, dog, horse, human, monkey, mouse, opossum, xenopus
Immunogen: a portion of amino acids 140-190 of human RAP2a
Imgenex
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100 µg

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302 €

IMG-659
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WB Erklärungen der Abkürzungen ansehen.
Rabbit IgG SR: human
Immunogen: synthetic peptides corresponding to amino acids 238-254 of the Anthrax PA protein (~83 kD)
Imgenex
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200 µl

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302 €

IMG-659E
related products

WB Erklärungen der Abkürzungen ansehen.
Rabbit Ig SR: human
Immunogen: synthetic peptide
Imgenex
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200 µl

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337 €

IMG-660
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WB Erklärungen der Abkürzungen ansehen.
Rabbit IgG SR: human
Immunogen: synthetic peptides corresponding to amino acids 186-192 of the Anthrax PA protein (~83 kD)
Imgenex
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200 µl

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302 €

IMG-660E
related products

WB Erklärungen der Abkürzungen ansehen.
Rabbit Ig SR: human
Immunogen: synthetic peptide
Imgenex
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200 µl

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302 €

IMG-6099A
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WB Erklärungen der Abkürzungen ansehen.
RDC1/CXCR7 is a 362 amino acid CXC chemokine receptor involved in a number of pathobiologic processes, including cell growth, survival and adhesion, and tumor growth.

Rabbit IgG SR: chimpanzee, cow, horse, human, monkey, mouse, rat
Immunogen: synthetic peptide
Imgenex
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100 µg

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302 €

IMG-134
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WB Erklärungen der Abkürzungen ansehen.
Mouse IgG SR: human, mouse
Immunogen: GST fusion protein containing 62 glutamine amino acid repeat
Imgenex
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100 µg

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302 €

IMG-283
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WB Erklärungen der Abkürzungen ansehen.
Rabbit IgG SR: human
Immunogen: synthetic peptides corresponding to amino acids 321-335 and 406-420 of human TRF1
Imgenex
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100 µg

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302 €

IMG-6885A
IHC ( paraffin )  Erklärungen der Abkürzungen ansehen.
CLEC8A, also called LOX-1 or OLR1, is one of the original C-Lectin type receptors (CLRs) associated with the fungal pattern recognition receptor Dectin-1. The DECTIN-1 associated clusters, including LOX-1, are found in the mammalian natural killer gene complex (NKC). LOX-1 is an innate immune receptor expressed on a variety of cells including activated macrophages, platelets, smooth muscle endothelium and fibroblasts. Expression of LOX-1 is increased by pro-inflammatory milieus in autoimmune pathologies like diabetes or atherosclerosis or hyperlipidemia caused also by oxidative stress or oxLDL. As activating immunoreceptors, CLRs are type II transmembrane proteins with a single CTLD, a C-type lectin-like domain that recognizes proteins and not carbohydrates. Antibody to LOX-1 is useful for functional, phenotyping or structural studies.

Rabbit IgG SR: human
Immunogen: A portion of amino acids 150-200 of human LOX-1
Imgenex
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100 µg

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302 €

IMG-5682
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IHC  ( frozen ) , IHC  ( paraffin ) , IP, WB Erklärungen der Abkürzungen ansehen.
Rabbit SR: human
Immunogen: synthetic peptide
Imgenex
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50 µl

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267 €

IMG-6290A
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WB Erklärungen der Abkürzungen ansehen.
AIRE is a transcriptional regulator protein that binds to DNA as a dimer and tetramer. AIRE is involved in immune regulation and is known to mediate E3 ubiquitin ligase activity.

Rabbit IgG SR: chimpanzee, human
Immunogen: synthetic peptide
Imgenex
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100 µg

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302 €

IMG-6367A
related products

WB Erklärungen der Abkürzungen ansehen.
eIF3J is an RNA-associated protein belonging to the eukaryotic translation initiation factor family. It belongs to the group of proteins involved in protein translation/synthesis where it binds to the 40S ribosomal subunit and promotes the binding of methionyl-tRNAi and mRNA to form the 40S initiation complex. eIF3J is a component of the eIF3 multiprotein complex, composed of at least 13 different subunits. It is also known to interact with eIF3S12. Ubiquitous expression is seen in most tissues.

Rabbit Ig SR: chimpanzee, dog, horse, human, mouse, orangutan
Immunogen: a portion of amino acids 230-280 of human eIF
Imgenex
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100 µg

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302 €

IMG-6291A
related products

WB Erklärungen der Abkürzungen ansehen.
PKD2 is a calcium independent, phospholipid dependent, protein kinase. It helps in controlling phorbol ester binding, catalytic activity, and nucleocytoplasmic shuttling.

Rabbit IgG SR: chimpanzee, dog, horse, human, mouse, opossum, rat
Immunogen: synthetic peptide
Imgenex
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100 µg

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302 €

IMG-6823A
WB Erklärungen der Abkürzungen ansehen.
IL-1beta (Interleukin-1 beta, IL-1b) is a potent inflammatory cytokine which has been well studied. Produced as a precursor, especially in myeloid cells and monocytes/macrophages, IL-1beta is processed by cleavage with caspase-1, or ICE, from the 31 kD inactive precursor to the 18kD active mature form secreted from cells as an end-result of the inflammasome complex and activation sequence. In response to various TLR ligands, myeloid cells or macrophages activate NLRP3 inflammasomes and secrete IL-1beta. The rate of IL-1beta processing has been correlated to redox state or levels of ROS generated. IL-1beta is directly involved in a variety of diseases -auto-inflammatory diseases, acute inflammatory attacks such as ischemic injury in myocardial infarcts or in chronic inflammatory processes of atherosclerosis or Type 2 diabetes. The ability to detect and quantitate active IL-1beta is critical for understanding how to regulate its activity as a therapeutic target.

Mouse IgG1 kappa SR: human
Immunogen: Full-length recombinant human IL-1beta
Imgenex
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100 µg

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302 €

IMG-6826A
WB Erklärungen der Abkürzungen ansehen.
IL-1beta (Interleukin-1 beta, IL-1b) is a potent inflammatory cytokine which has been well studied. Produced as a precursor, especially in myeloid cells and monocytes/macrophages, IL-1beta is processed by cleavage with caspase-1, or ICE, from the 31 kD inactive precursor to the 18kD active mature form secreted from cells as an end-result of the inflammasome complex and activation sequence. In response to various TLR ligands, myeloid cells or macrophages activate NLRP3 inflammasomes and secrete IL-1beta. The rate of IL-1beta processing has been correlated to redox state or levels of ROS generated. IL-1beta is directly involved in a variety of diseases -?auto-inflammatory diseases, acute inflammatory attacks such as ischemic injury in myocardial infarcts or in chronic inflammatory processes of atherosclerosis or Type 2 diabetes. The ability to detect and quantitate active IL-1beta is critical for understanding how to regulate its activity as a therapeutic target

Mouse IgG1 kappa SR: human
Immunogen: Full-length recombinant human IL-1beta protein
Imgenex
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100 µg

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302 €

IMG-6827A
WB Erklärungen der Abkürzungen ansehen.
IL-1beta (Interleukin-1 beta, IL-1b) is a potent inflammatory cytokine which has been well studied. Produced as a precursor, especially in myeloid cells and monocytes/macrophages, IL-1 beta is processed by cleavage with caspase-1, or ICE, from the 31 kD inactive precursor to the 18kD active mature form secreted from cells as an end-result of the inflammasome complex and activation sequence. In response to various TLR ligands, myeloid cells or macrophages activate NLRP3 inflammasomes and secrete IL-1 beta. The rate of IL-1 beta processing has been correlated to redox state or levels of ROS generated. IL-1 beta is directly involved in a variety of diseases -auto-inflammatory diseases, acute inflammatory attacks such as ischemic injury in myocardial infarcts or in chronic inflammatory processes of atherosclerosis or Type 2 diabetes. The ability to detect and quantitate active IL-1 beta is critical for understanding how to regulate its activity as a therapeutic target.

Mouse IgG1 kappa SR: human
Immunogen: Full-length recombinant human IL-1 beta protein
Imgenex
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100 µg

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302 €

IMG-6828A
WB Erklärungen der Abkürzungen ansehen.
IL-1beta (Interleukin-1 beta, IL-1beta) is a potent inflammatory cytokine which has been well studied. Produced as a precursor, especially in myeloid cells and monocytes/macrophages, IL-1b is processed by cleavage with caspase-1, or ICE, from the 31 kD inactive precursor to the 18kD active mature form secreted from cells as an end-result of the inflammasome complex and activation sequence. In response to various TLR ligands, myeloid cells or macrophages activate NLRP3 inflammasomes and secrete IL-1b. The rate of IL-1b processing has been correlated to redox state or levels of ROS generated. IL-1b is directly involved in a variety of diseases -auto-inflammatory diseases, acute inflammatory attacks such as ischemic injury in myocardial infarcts or in chronic inflammatory processes of atherosclerosis or Type 2 diabetes. The ability to detect and quantitate active IL-1b is critical for understanding how to regulate its activity as a therapeutic target.

Mouse IgG1 kappa SR: human
Immunogen: Full-length recombinant human IL-1b protein
Imgenex
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100 µg

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302 €

IMG-6830A
FC  ( IC ) , IHC  ( paraffin ) , WB Erklärungen der Abkürzungen ansehen.
IL-1beta (Interleukin-1 beta, IL-1b) is a potent inflammatory cytokine which has been well studied. Produced as a precursor, especially in myeloid cells and monocytes/macrophages, Interleukin-1 beta is processed by cleavage with caspase-1, or ICE, from the 31 kD inactive precursor to the 18kD active mature form secreted from cells as an end-result of the inflammasome complex and activation sequence. In response to various TLR ligands, myeloid cells or macrophages activate NLRP3 inflammasomes and secrete Interleukin-1 beta. The rate of Interleukin-1 beta processing has been correlated to redox state or levels of ROS generated. Interleukin-1 beta is directly involved in a variety of diseases -auto-inflammatory diseases, acute inflammatory attacks such as ischemic injury in myocardial infarcts or in chronic inflammatory processes of atherosclerosis or Type 2 diabetes. The ability to detect and quantitate active Interleukin-1 beta is critical for understanding how to regulate its activity as a therapeutic target.

Mouse IgG1 kappa SR: human
Immunogen: Full-length recombinant human Interleukin-1 beta protein
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100 µg

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302 €

IMG-403
related products

WB Erklärungen der Abkürzungen ansehen.
Rabbit IgG SR: human, mouse, rat
Immunogen: synthetic peptide corresponding to amino acids 281-298 of human UNG
Imgenex
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100 µg

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302 €

IMG-586
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WB Erklärungen der Abkürzungen ansehen.
Rabbit IgG SR: human
Immunogen: synthetic peptide corresponding amino acids 379-389 of human JNK2
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100 µg

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302 €

IMG-6669A
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WB Erklärungen der Abkürzungen ansehen.
The E3 ubiquitin-protein ligase NEDD4 is a Ubl conjugation pathway protein. It contains one HECT (E6AP-type E3 ubiquitin-protein ligase) domain and four WW domains. It is involved in the pathway leading to the degradation of VEGFR-2/KDFR, independently of its ubiquitin-ligase activity. It acts as a potential proto-oncogene that negatively regulates PTEN via ubiquitination, a paradigm analogous to that of Mdm2 and p53. It is also reported to be involved in the budding of many viruses and is the regulator of epithelial Na channels, which lead to arterial hypertension. NEDD4 protein is localized to the sarcolemmal region of muscle fibers. Increase in NEDD4 protein expression leads to unloaded and denervated muscles as well as a decrease in Notch1 expression. Hence it acts as down regulator of Notch-1 gene expression.

Rabbit Ig SR: horse, human, monkey, mouse, rat
Immunogen: a portion of amino acids 950-1000 of human NEDD4
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100 µg

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302 €

IMG-5733
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WB, IHC  ( paraffin ) , IHC  ( frozen ) , IP Erklärungen der Abkürzungen ansehen.
Rabbit SR: human
Immunogen: synthetic peptide
Imgenex
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50 µl

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267 €

IMG-546
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WB Erklärungen der Abkürzungen ansehen.
Rabbit IgG SR: human, mouse, rat
Immunogen: synthetic peptides corresponding to amino acids 22-36 and 317-331 of human SMAD8
Imgenex
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200 µl

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302 €

IMG-550
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WB Erklärungen der Abkürzungen ansehen.
Rabbit IgG SR: human, mouse, rat
Immunogen: synthetic peptides corresponding to amino acids 20-34 and 316-330 of human Smad5
Imgenex
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200 µl

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302 €

IMG-566
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WB Erklärungen der Abkürzungen ansehen.
Rabbit IgG SR: human, mouse, rat
Immunogen: synthetic peptide corresponding to amino acids 23-36 & 317-332 of human Smad9
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200 µl

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302 €

IMG-6125A
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Rabbit Ig SR: chimpanzee, cow, dog, human, monkey, mouse, rat
Immunogen: synthetic peptide
Imgenex
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50 µg

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337 €

IMG-6126A
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Rabbit Ig SR: chimpanzee, cow, dog, horse, human, monkey, zebrafish
Immunogen: synthetic peptide
Imgenex
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50 µg

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302 €

IMG-6668A
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WB Erklärungen der Abkürzungen ansehen.
NACHT, LRR and PYD domains-containing protein 3 belongs to the NLRP family and it contains one DAPIN domain, seven LRR (leucine-rich) repeats and one NATCH domain. It interacts with the apoptosis-associated speck-like protein PYCARD/ASC, which contains a caspase recruitment domain and is a member of the NALP3 inflammasome complex. This complex functions as an upstream activator of NF-kappaB signaling and it plays a role in the regulation of inflammation, the immune response and apoptosis. It is also reported that the NLRP3 inflammasome can be activated by pathogen-associated molecular patterns (PAMPs) or endogenous danger-associated molecular patterns (DAMPs). The activation of the NLRP3 inflammasome results in proteolytic activation and secretion of cytokines of the interleukin-1 (IL-1) family. Mutations in this gene are associated with familial cold autoinflammatory syndrome (FCAS), Muckle-Wells syndrome (MWS), chronic infantile neurological cutaneous and articular (CINCA) syndrome and neonatal-onset multi-system inflammatory disease (NOMID).

Rabbit IgG SR: human, monkey, mouse, rat
Immunogen: a portion of amino acids 1-50 of human NALP3
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100 µg

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302 €

IMG-5815A
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IF / ICC, WB Erklärungen der Abkürzungen ansehen.
Rabbit IgG SR: bovine, chimpanzee, dog, human, mouse
Immunogen: synthetic peptide
Imgenex
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100 µg

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302 €

IMG-6797A
WB, IHC ( paraffin )  Erklärungen der Abkürzungen ansehen.
SAMHD1 is a 72kDa protein and putative inhibitor of HIV-1 replication in myeloid cells. SAMHD1 appears to be degraded from Vpx proteins from HIV-2 or SIV which converts HIV-1 infection refractive cells such as dendritic cells or monocytes into HIV-1 permissive cells . SIVsm and HIV-2 encoded Vpx override SAMHD1 inhibition of viral replication which ordinarily induces the innate antiviral immunity serving to confine viral infection in natural hosts. SAMHD1 was initially cloned from human DCs as an interferon (IFN)-inducible gene again reflecting it as another potential innate immune molecule with anti-viral activities though control of IFN responses. SAMHD1 appears to exert HIV-1 inhibitory effects early in the post entry process during reverse transcription. Proteosomal degradation of SAMHD1 perhaps through elimination of normal interaction with CUL4-DDB1 VPRBP binding complex is proposed as a mechanism for converting from non-permissive to permissive HIV-1 in myeloid cells. SAMHD1 specific antibody provides an opportunity to examine its expression in Lentivirus vector transfection systems or retrovirus infected cells as well as control of viral replication in artificial or natural retroviral infections.

Rabbit IgG SR: chimpanzee, human, Orangutan, white-cheeked gibbon
Immunogen: portion of amino acids 1-50 from human SAMHD1
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100 µg

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302 €

IMG-6816A
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IHC, WB Erklärungen der Abkürzungen ansehen.
SAMHD1 is a 72kDa protein and putative inhibitor of HIV1 replication in myeloid cells. SAMHD1 appears to be degraded from Vpx proteins from HIV2 or SIV which converts HIV1 infection refractive cells such as DCs or monocytes into HIV1 permissive cells. SIVsm and HIV2 encoded Vpx override SAMHD1 inhibition of viral replication which ordinarily induces the innate antiviral immunity serving to confine viral infection in natural hosts. SAMHD1 was initially cloned from human DCs as an interferon (IFN)-g-inducible gene again reflecting it as another potential innate immune molecule with anti-viral activities though control of IFN responses. SAMHD1 appears to exert HIV1 inhibitory effects early in the post entry process during reverse transcription. Proteosomal degradation of SAMHD1 perhaps through elimination of normal interaction with CUL4-DDB1 VPRBP binding complex is proposed as a mechanism for converting from non-permissive to permissive HIV1 in myeloid cells. SAMHD1 specific antibody provides an opportunity to examine its expression in Lentivirus vector transfection systems or retrovirus infected cells as well as control of viral replication in artificial or natural retroviral infections.

Rabbit Ig SR: elephant, horse, dog, cow, frog, cat, mole rat, chinese hamster
Immunogen: portion of amino acids 410-460 from human SAMHD1
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100 µg

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302 €

IMG-531A
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WB Erklärungen der Abkürzungen ansehen.
Rabbit IgG SR: human, mouse, rat
Immunogen: synthetic peptide corresponding to amino acids 12-18 and 36-50 of human Smad7
Imgenex
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100 µg

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302 €

IMG-531E
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WB Erklärungen der Abkürzungen ansehen.
Rabbit IgG SR: human, mouse, rat
Immunogen: synthetic peptide
Imgenex
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200 µl

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337 €

IMG-2203
TLR3 activation Erklärungen der Abkürzungen ansehen.
Polyinosinic-polycytidylic acid (Poly(I:C)) is a synthetic analog of double stranded RNA (dsRNA) of viruses. Poly (I:C) is known to induce type-1 interferon (IFN) through TLR3. Poly(I:C) directly binds to TLR3.
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1 mg

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220 €

IMG-315A
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FC  ( Cell Surface ) , FC  ( Intracellular ) , IF / ICC, IHC  ( paraffin ) , IP, WB Erklärungen der Abkürzungen ansehen.
Mouse IgG1 kappa SR: dog, human
Immunogen: synthetic peptide
Imgenex
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100 µg

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337 €

IMG-315AF488
FC ( CS,IC ) , IF / ICC Erklärungen der Abkürzungen ansehen.
The TLR family is a phylogenetically conserved mediator of innate immunity that is essential for microbial recognition. TLR3 has a restricted expression pattern being expressed in dendritic cells (DC).

Mouse IgG1 kappa SR: dog, human
Immunogen: synthetic peptide
Imgenex
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100 µg

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395 €

IMG-315AF647
FC ( CS ) , FC ( IC ) , IF / ICC Erklärungen der Abkürzungen ansehen.
The Toll-like receptor (TLR) family in mammal comprises a family of transmembrane proteins characterized by multiple copies of leucine rich repeats in the extracellular domain and IL-1 receptor motif in the cytoplasmic domain. Like its counterparts in Drosophila, TLRs signal through adaptor molecules and could constitute an important and unrecognized component of innate immunity in humans. The TLR family is a phylogenetically conserved mediator of innate immunity that is essential for microbial recognition. TLRs characterized so far activate the MyD88/interleukin-1 receptor-associated kinase (IRAK) signaling pathway. Ten human homologs of TLRs (TLR1-10) have been described. TLR3 cDNA codes for a protein with approximate molecular weight of 120 kDa. TLR3 has a restricted expression pattern being expressed in dendritic cells (DC) (4-6). TLR3 mRNA expression was detected by in situ hybridization in DC and lymph nodes. The expression of TLR3 in a single cell type may indicate a specific role for this molecule in a restricted set

Mouse IgG1 kappa SR: dog, human, mouse
Immunogen: KLH-conjugated synthetic peptide of human TLR3
Imgenex
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100 µg

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395 €

IMG-315B
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ELISA, FC  ( Cell Surface ) , FC  ( Intracellular ) , IHC  ( paraffin )  Erklärungen der Abkürzungen ansehen.
Mouse IgG1 kappa SR: human
Immunogen: synthetic peptide
Imgenex
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100 µg

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348 €

IMG-315C
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FC  ( Cell Surface ) , FC  ( Intracellular ) , IF / ICC Erklärungen der Abkürzungen ansehen.
Mouse IgG1 kappa SR: human
Immunogen: synthetic peptide
Imgenex
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100 µg

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348 €

IMG-315D
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FC  ( Cell Surface ) , FC  ( Intracellular )  Erklärungen der Abkürzungen ansehen.
Mouse IgG1 kappa SR: human
Immunogen: synthetic peptide
Imgenex
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100 µg

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348 €

IMG-5348A
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WB Erklärungen der Abkürzungen ansehen.
TLR3 has a restricted expression pattern being expressed in dendritic cells (DC).

Rabbit IgG SR: human
Immunogen: synthetic peptide corresponding to amino acids 755-767 of human TLR3 (pTyr759)
Imgenex
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20 µg

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348 €

IMG-6315A
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IHC, WB Erklärungen der Abkürzungen ansehen.
This polyclonal antibody may block dsRNA binding to TLR3.

Rabbit IgG SR: chimpanzee, cow, gorilla, human, macaque, mouse, opossum, rat
Immunogen: synthetic peptide containing H-539 and N-541, two important amino acids involved in the binding of dsRNA to TLR3
Imgenex
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100 µg

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302 €

IMG-6444A
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IHC ( paraffin ) , WB Erklärungen der Abkürzungen ansehen.
TLR3 has a restricted expression pattern being expressed in dendritic cells (DC). TLR3 mRNA expression was detected by in situ hybridization in DC and lymph nodes. The expression of TLR3 in a single cell type may indicate a specific role for this molecule in a restricted setting.

Rabbit IgG SR: chimpanzee, gorilla, human, macaque, rhesus monkey
Immunogen: synthetic peptide
Imgenex
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100 µg

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302 €

IMG-6755AF488
FC  ( IC )  Erklärungen der Abkürzungen ansehen.
TLR3, also classified as CD283, appears to be one of the major sensors of RNA viruses. Viral recognition by endosomal TLRs induces Type I Interferon production and release. TLR3 is the only human TLR which does not utilize MyD88 as an adaptor molecule instead utilizing TRIF in a signaling path which results in downstream activation of IRF-3 and NF-kappaB. IRF-3 is a major inducer itself of Type I interferons like IFNb through activation via viral derived dsRNAs or poly I:C. TLR3 activation leads not only to Type I interferon induction but also to other inflammatory cytokines which result in DC maturation. Through its recognition of dsRNA, TLR3 also appears to potentiate immune responses and TLR3 agonists have been exploited as vaccine adjuvants.

Rabbit IgG SR: human, mouse
Immunogen: portion of amino acids 325-375 of mouse TLR3.
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100 µg

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348 €

IMG-6755AF647
FC  ( IC )  Erklärungen der Abkürzungen ansehen.
TLR3, also classified as CD283, appears to be one of the major sensors of RNA viruses. Viral recognition by endosomal TLRs induces Type I Interferon production and release. TLR3 is the only human TLR which does not utilize MyD88 as an adaptor molecule instead utilizing TRIF in a signaling path which results in downstream activation of IRF-3 and NF-kappaB. IRF-3 is a major inducer itself of Type I interferons like IFNb through activation via viral derived dsRNAs or poly I:C. TLR3 activation leads not only to Type I interferon induction but also to other inflammatory cytokines which result in DC maturation. Through its recognition of dsRNA, TLR3 also appears to potentiate immune responses and TLR3 agonists have been exploited as vaccine adjuvants.

Rabbit IgG SR: human, mouse
Immunogen: portion of amino acids 325-375 of mouse TLR3.
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100 µg

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348 €

IML-103
Agonist screening, functional assays Erklärungen der Abkürzungen ansehen.
Stably co-transfected cell line which expresses human Toll-like receptor 3 (TLR3) and the secreted alkaline phosphatase (SEAP) reporter gene under the transcriptional control of an NF-kappaB response element.
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1 each

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1223 €

IML-203
FC calibration, control Erklärungen der Abkürzungen ansehen.
TLR3/HEK 293 is a stably transfected cell line which expresses full-length human Toll-like receptor 3 (TLR3) with an N-terminal HA tag.
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1 each

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947 €

IMG-303-1
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IHC  ( paraffin ) , WB Erklärungen der Abkürzungen ansehen.
Rabbit IgG SR: human, mouse, rat
Immunogen: synthetic peptides of human AIF. AIF = Apoptosis-Inducing Factor
Imgenex
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50 µg

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348 €

IMG-5658
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IHC  ( frozen ) , IHC  ( paraffin ) , IP, WB Erklärungen der Abkürzungen ansehen.
Rabbit SR: cow, dog, human, mouse, rat
Immunogen: synthetic peptide
Imgenex
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50 µl

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267 €

IMG-6265A
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WB Erklärungen der Abkürzungen ansehen.
AXL may function as a signal transducer between specific cell types of mesodermal origin and may transduce signals from the extracellular matrix into the cytoplasm

Rabbit Ig SR: human, mouse, rat
Immunogen: synthetic peptide
Imgenex
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100 µg

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337 €

IMG-413
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WB Erklärungen der Abkürzungen ansehen.
Mouse IgM SR: human
Immunogen: synthetic peptide of human Presenilin-2 (PS-2) It tested negative in mouse NIH 3T3 cells
Imgenex
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200 µl

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302 €

IMG-335
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WB Erklärungen der Abkürzungen ansehen.
Rabbit IgG SR: human
Immunogen: synthetic peptide of human Mre11
Imgenex
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100 µg

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302 €

IMG-292
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WB Erklärungen der Abkürzungen ansehen.
Rabbit IgG SR: human
Immunogen: synthetic peptide corresponding to amino acids 771-787 of human Stat5B
Imgenex
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100 µg

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302 €

IMG-5120A
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WB Erklärungen der Abkürzungen ansehen.
WB: 1-3 ug/ml

Rabbit IgG SR: human
Immunogen: synthetic peptide corresponding to amino acids 502-515
Imgenex
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100 µg

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302 €

IMG-5950A
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WB Erklärungen der Abkürzungen ansehen.
FOXO1A is a 655 amino acid protein belonging to the forkhead family of transcription activators which is characterized by a distinct forkhead domain. The specific function of this protein has not yet been determined, however, it may play a role in myogenic growth and differentiation. It is also known to have a tumor suppressor function by inhibiting cell proliferation and survival. When fused to PAX3 it is known to cause alveolar rhabdomyosarcoma.

Rabbit Ig SR: chimpanzee, cow, dog, human, monkey, mouse, rat
Immunogen: a portion of amino acids 250-300 of human FOXO1a protein
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100 µg

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302 €

IMG-6384A
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WB Erklärungen der Abkürzungen ansehen.
FOXO1A is a protein belonging to the forkhead family of transcription activators which is characterized by a distinct forkhead domain.

Rabbit Ig SR: chimpanzee, bovine, dog, human, monkey, mouse, rat
Immunogen: synthetic peptide
Imgenex
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20 µg

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220 €

IMG-309
related products

WB Erklärungen der Abkürzungen ansehen.
Rabbit IgG SR: human
Immunogen: synthetic peptides corresponding to amino acids 175-188, 525-540, and 567-580 of human IKKi/e protein It has tested negative on mouse NIH 3T3 cells
Imgenex
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100 µg

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302 €

IMG-506
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WB Erklärungen der Abkürzungen ansehen.
Rabbit IgG SR: human, mouse
Immunogen: mixture of synthetic peptides corresponding to human PRMT6 amino acid sequence PRMT: Protein aRginine MethylTransferase
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200 µl

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302 €

IMG-6260A
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WB Erklärungen der Abkürzungen ansehen.
FNBP1 interacts with sorting nexin 2 (SNX2), tankyrase (TNKS), and dynamin and is an important regulator of endocytosis.

Rabbit Ig SR: human, mouse, rat
Immunogen: synthetic peptide
Imgenex
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100 µg

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302 €

IMG-6806A
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WB Erklärungen der Abkürzungen ansehen.
DC-SIGN, also called CD209, is a C type lectin receptor and an acronym for Dendritic Cell-Specific intracellular adhesion molecule 3 (ICAM-3) grabbing nonintegrin protein. DC-SIGN (CD209) is a 45kDa receptor which binds mannans and glycans on bacteria, viruses and fungi. Expressed on Dendritic Cells (DCs) and DC-like macrophages, DC-SIGN is an important cell interaction molecule mediating DC-T cell or DC-Neutrophil responses. DC-SIGN is especially important in DC Th1 interaction, regulating Th1 activity through it?s role as a pathogen receptor. Interaction between DC-SIGN and TLR4 has been demonstrated for induction of inflammatory responses. As a CLR and innate immune receptor, DC-SIGN detection and quantitation with antibody probes are used as both a phenotype and indicator of a functional role in anti-microbial responses of DC's.

Rabbit SR: ape, human, mouse, orangutan
Immunogen: portion of amino acids 320-370 from human DC-SIGN (CD209)
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100 µg

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302 €

IMG-6440A
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WB Erklärungen der Abkürzungen ansehen.
MAGE-D2, also known as Melanoma-associated antigen D2, belongs to the melanoma antigen encoding gene (MAGE) family with a MAGE domain. Rat and mouse orthologues have been isolated. Compared to other proteins (MAGE-A, MAGE- B and MAGE-C clusters) MAGE-D2 is expressed ubiquitously. This intracellular protein shows high expression in specific brain regions and in the interstitium of testes. Though the exact function of this protein is yet to be deduced, MAGE-D2 is considered as a hot spot for X-linked mental retardation. Research reveals that MAGE-D2 might have some role in breast and gastric cancer, as well as in hepatocellular carcinoma. MAGE-D2 is also known to interact physically with p53 and modify its activity, thus acting as a p53-dissociator.

Rabbit IgG SR: chimpanzee, dog, horse, human, mouse, rat
Immunogen: two amino acids of human MAGE-D2
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100 µg

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302 €

IMG-6087A
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WB Erklärungen der Abkürzungen ansehen.
Rabbit IgG SR: bovine, human, mouse
Immunogen: synthetic peptide
Imgenex
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100 µg

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302 €

IMG-6088A
related products

WB Erklärungen der Abkürzungen ansehen.
Rabbit IgG SR: human, mouse, rat
Immunogen: synthetic peptide
Imgenex
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100 µg

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302 €

IMG-2011set
TLR4 inhibition Erklärungen der Abkürzungen ansehen.
Set contains 1 mg each of VIPER and CP7 (control peptide). VIPER (viral inhibitory peptide of TLR4) is a TLR4 specific inhibitory peptide that potentently inhibits TLR4-mediated responses and is inert towards other TLR pathways (Bowie et al. 2010, Lysakova-Devine et al. 2010). VIPER consists of an 11 amino acid (KYSFKLILAEY)inhibitory sequence, derived from the A46 vaccinia virus protein, linked to a 9R (RRRRRRRRR) homopolymer delivery sequence. VIPER interferes with the interaction between TLR4 and its adaptor proteins Mal and TRAM. It is thought that VIPER inhibits TLR4 signaling by binding to the TIR domains of Mal and TRAM. Since TIR domains engage the MAl and TRAM adaptor proteins with TLR4, blocking adaptor TIR domains with VIPER would disrupt propagation of the TLR4 signal. However, the exact mechanism by which VIPER inhibits TLR4 signaling remains to be fully elucidated. Likewise, the specific VIPER binding sites on TRAM and Mal TIR domains remain to be identified.
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1 set

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395 €

IMG-417A
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FC  ( CCS, IC ) , IF / ICC, IP Erklärungen der Abkürzungen ansehen.
Mouse IgG2a kappa SR: human
Immunogen: Ba/F3 cell line expressing human TLR4 cell surface antigen
Imgenex
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100 µg

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337 €

IMG-417AF488
related products

ICC, IF, FC  ( CS, IC )  Erklärungen der Abkürzungen ansehen.
Mouse IgG2a kappa SR: mouse
Immunogen: Ba/F3 cell line expressing human TLR4 cell surface antigen
Imgenex
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100 µg

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395 €

IMG-417B
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ELISA, IP, ICC, FC Erklärungen der Abkürzungen ansehen.
Mouse IgG2a kappa SR: dog, human
Immunogen: Ba/F3 cell line expressing human TLR4 cell surface antigen
Imgenex
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100 µg

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348 €

IMG-417C
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ICC, IF, FC  ( CS, IC )  Erklärungen der Abkürzungen ansehen.
Mouse IgG2a kappa SR: dog, human
Immunogen: Ba/F3 cell line expressing human TLR4 cell surface antigen
Imgenex
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100 µg

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395 €

IMG-417E
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FA  ( Neutr. ) , FC  ( CS, IC ) , IF, ICC, IP Erklärungen der Abkürzungen ansehen.
Mouse IgG2a SR: human
Immunogen: Ba/F3 cell line expressing human TLR4 cell surface antigen
Imgenex
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100 µg

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348 €

IMG-5031A
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FC  ( Cell Surface ) , WB Erklärungen der Abkürzungen ansehen.
Mouse IgG2b kappa SR: human, mouse, rat
Immunogen: synthetic peptide corresponding to amino acids 125-140 of human TLR4
Imgenex
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100 µg

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337 €

IMG-5031AF647
FC ( CS ) , FC ( IC )  Erklärungen der Abkürzungen ansehen.
The Toll-like receptor (TLR) family in mammal comprises a family of transmembrane proteins characterized by multiple copies of leucine rich repeats in the extracellular domain and IL-1 receptor motif in the cytoplasmic domain. Like its counterparts in Drosophila, TLRs signal through adaptor molecules. The TLR family is a phylogenetically conserved mediator of innate immunity that is essential for microbial recognition. Ten human homologs of TLRs (TLR1-10) have been described. Among this family of receptors, TLR2 and TLR4 have been most studied. These studies have suggested that TLR2 and TLR4 may serve as potential main mediators of LPS signaling (4,5). The TLR4 cDNA codes for a protein consisting of 799 amino acids with approximate molecular weight of 88 kDa.

Mouse IgG2b kappa SR: human, mouse, rat
Immunogen: a portion of amino acids 100-200 of human TLR4
Imgenex
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100 µg

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395 €

IMG-5031C
FC  ( Cell Surface )  Erklärungen der Abkürzungen ansehen.
Mouse IgG2b kappa SR: human, mouse, rat
Immunogen: synthetic peptide (amino acids 125-140)
Imgenex
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100 µg

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348 €

IMG-577
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WB, IP Erklärungen der Abkürzungen ansehen.
Rabbit IgG SR: human, mouse
Immunogen: synthetic peptide corresponding to amino acids 706-728
Imgenex
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100 µg

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302 €

IMG-579A
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IHC  ( paraffin ) , WB Erklärungen der Abkürzungen ansehen.
Rabbit IgG SR: human, mouse
Immunogen: synthetic peptide corresponding to amino acids 418-435
Imgenex
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100 µg

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302 €

IMG-579AF488
FC  ( CS )  Erklärungen der Abkürzungen ansehen.
The Toll-like receptor (TLR) family in mammal comprises a family of transmembrane proteins characterized by multiple copies of leucine rich repeats in the extracellular domain and IL-1 receptor motif in the cytoplasmic domain. Like its counterparts in Drosophila, TLRs signal through adaptor molecules. The TLR family is a phylogenetically conserved mediator of innate immunity that is essential for microbial recognition. Ten human homologs of TLRs (TLR1-10) have been described. Among this family of receptors, TLR2 and TLR4 have been most studied. These studies have suggested that TLR2 and TLR4 may serve as potential main mediators of LPS signaling. The mouse TLR4 cDNA codes for a protein consisting of 839 amino acids with approximate molecular weight of 90 kDa.

Rabbit IgG SR: human, mouse
Immunogen: Synthetic peptide corresponding to amino acids 420-435 of human TLR4.
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100 µg

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348 €

IMG-6276A
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Studies have suggested that TLR2 and TLR4 may serve as potential main mediators of LPS signaling.

Rabbit Ig SR: human, mouse, rat
Immunogen: synthetic phospho-peptide
Imgenex
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20 µg

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348 €

IMG-6285A
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TLR4 is involved in signal transduction events induced by LPS. TLR4 mediates the production of cytokines necessary for the development of effective immunity.

Rabbit Ig SR: baboon, chimpanzee, human, macaque, rhesus monkey
Immunogen: synthetic peptide
Imgenex
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100 µg

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302 €

IMG-6307A
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The TLR family is a phylogenetically conserved mediator of innate immunity that is essential for microbial recognition. Multiple studies have suggested that TLR2 and TLR4 may serve as potential main mediators of LPS signaling.

Rabbit Ig SR: bison, chimpanzee, bovine, gorilla, horse, human, macaque
Immunogen: synthetic peptide
Imgenex
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100 µg

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302 €

IML-104
Agonist screening, functional assays Erklärungen der Abkürzungen ansehen.
Stably co-transfected cell line which expresses human Toll-like receptor 4 (TLR4) and the secreted alkaline phosphatase (SEAP) reporter gene under the transcriptional control of an NF-kappaB response element.
Imgenex
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1 each

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1223 €

IML-104MD2CD14
Agonist / antagonist screening, functional assays Erklärungen der Abkürzungen ansehen.
Content: 3-4 x 10e6 cells. TLR4/MD-2/NF-kappaB/SEAPorterTM HEK 293 is a stably co-transfected cell line which expresses full-length human Toll-like receptor 4 (TLR4), human MD-2 and secreted alkaline phosphatase (SEAP) reporter genes under the transcriptional control of an NF-kappaB response element. The cell line has been validated by a ligand dose response assay and can be used for TLR4-dependent functional assays as well as screening of TLR4 agonists or antagonists.
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1338 €

IML-204
FC calibration, control Erklärungen der Abkürzungen ansehen.
TLR4/HEK 293 is a stably transfected cell line which expresses full-length human Toll-like receptor 4 (TLR4) with an N-terminal HA tag.
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947 €

IMG-6271A
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EIF4B binds to both mRNA and 18S ribosomal RNA and thus acts as a bridge between the mRNA and the 40S ribosomal subunit during translation initiation.

Rabbit Ig SR: bovine, chicken, human, mouse, orangutan, rat
Immunogen: synthetic peptide corresponding to a portion of amino acids 150-200 of human eIF4B
Imgenex
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100 µg

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302 €

IMG-6309A
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eIF4B binds to both mRNA and 18S ribosomal RNA and thus acts as a bridge between the mRNA and the 40S ribosomal subunit during translation initiation.

Rabbit Ig SR: chimpanzee, human, mouse, orangutan, rhesus monkey
Immunogen: synthetic peptide
Imgenex
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100 µg

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302 €

IMG-6795A
WB Erklärungen der Abkürzungen ansehen.
The 14-3-3 family of proteins are important regulatory molecules ubiquitiously expressed in all eukarryotic cells which bind to numerous signaling proteins in various pathways driving critical cellular pathways of apoptosis, differentiation and cell cycle. 14-3-3 theta specifically has also been shown to play an important regulatory role in the TLR2 signaling pathways as a negative regulator of TLR2 ligand Pam3CySK4 induced NF-kappaB activation. 14-3-3 theta has previously been shown to interact with TLR4 ligand and MyD88 dependent phosphorylated PKC epsilon. 14-3-3 theta in the TLR4 signaling pathway is a positive regulator controlling release of IRF3 indcuded pro-inflammatory cytokines RANTES and IP-10. Currently identified by mass spec as part of the TLR2 signaling complex and taken along with TLR4 data, a 14-3-3 theta antibody can be used to examine the different regulatory functions of 14-3-3 theta for different TLRs through its interaction with common or unique TLR signaling adaptor molecules in addition to MyD88 or PKC epsilon such as TRAM or TRIF allowing further clarification of TLR specific pathway regulation.

Rabbit IgG SR: human, macaque, rhesus monkey
Immunogen: A portion of amino acids 40-90 from human 14-3-3
Imgenex
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100 µg

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302 €

IMG-6796A
WB Erklärungen der Abkürzungen ansehen.
The 14-3-3 family of proteins are important regulatory molecules ubiquitiously expressed in all eukarryotic cells which bind to numerous signaling proteins in various pathways driving critical cellular pathways of apoptosis, differentiation and cell cycle. 14-3-3 theta specifically has also been shown to play an important regulatory role in the TLR2 signaling pathways as a negative regulator of TLR2 ligand Pam3CySK4 induced NF-kappaB activation. 14-3-3 theta has previously been shown to interact with TLR4 ligand and MyD88 dependent phosphorylated PKC epsilon. 14-3-3 theta in the TLR4 signaling pathway is a positive regulator controlling release of IRF3 indcuded pro-inflammatory cytokines RANTES and IP-10. Currently identified by mass spec as part of the TLR2 signaling complex and taken along with TLR4 data, a 14-3-3 theta antibody can be used to examine the different regulatory functions of 14-3-3 theta for different TLRs through its interaction with common or unique TLR signaling adaptor molecules in addition to MyD88 or PKC epsilon such as TRAM or TRIF allowing further clarification of TLR specific pathway regulation.

Rabbit IgG SR: cat, chicken, chinese hamster, dog, human, macaque, mouse, opossum, orangutan, panda, swine, platypus, rat, rhesus monkey
Immunogen: A portion of amino acids 125-175 from human 14-3-3
Imgenex
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302 €

IMG-5705
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IHC  ( frozen ) , IHC  ( paraffin ) , IP, WB Erklärungen der Abkürzungen ansehen.
Rabbit SR: dog, gerbil, human, mouse, rat
Immunogen: recombinant catalytically active human Caspase-9 protein
Imgenex
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50 µl

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302 €

IMG-5706
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IHC  ( frozen ) , IHC  ( paraffin ) , IP, WB Erklärungen der Abkürzungen ansehen.
Rabbit SR: dog, gerbil, human, mouse, rat
Immunogen: recombinant full-length human Caspase-9 protein (pro-form)
Imgenex
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50 µl

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302 €

IMG-5707
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IHC  ( frozen ) , IHC  ( paraffin ) , IP, WB Erklärungen der Abkürzungen ansehen.
Rabbit SR: human
Immunogen: synthetic peptide
Imgenex
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50 µl

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267 €

IMG-5708
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IHC  ( frozen ) , IHC  ( paraffin ) , IP, WB Erklärungen der Abkürzungen ansehen.
Rabbit SR: human
Immunogen: synthetic peptide
Imgenex
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50 µl

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267 €

IMG-5709
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IHC  ( frozen ) , IHC  ( paraffin ) , IP, WB Erklärungen der Abkürzungen ansehen.
Rabbit SR: human
Immunogen: synthetic phosphopeptide corresponding to amino acids 188-206
Imgenex
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50 µl

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267 €

IMG-571
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Rabbit IgG SR: human, mouse
Immunogen: synthetic peptides corresponding to amino acids 4-16 and 60-75 of human SUMO 2/3
Imgenex
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100 µg

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302 €

IMG-6053A
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Rabbit Ig SR: human, monkey
Immunogen: synthetic peptide
Imgenex
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100 µg

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302 €

IMG-6527A
IHC ( paraffin )  Erklärungen der Abkürzungen ansehen.
Flightless-1 homolog is a 1269 amino acid containing protein with a gelsolin-like actin binding domain and an N-terminal leucine rich protein-protein interaction domain acts as a coactivator in transcriptional activation by hormone-activated nuclear receptors (NR) and in conjunction with NCOA2 and CARM1. FLIIH is involved in estrogen hormone signaling and early embryonic development. The protein also plays a role in regulation of cytoskeletal rearrangements involved in cytokinesis and cell migration. Deletion of the FLII gene may be a cause of Smith-Magenis syndrome (SMS=

Rabbit Ig SR: chimpanzee, horse, human, mouse, rat, rhesus monkey
Immunogen: a portion of amino acids 90-140 of human FLIIH
Imgenex
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100 µg

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302 €

IMG-438
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WB: 1-2 ug/ml

Rabbit IgG SR: human
Immunogen: synthetic peptide corresponding to amino acids 361-372 of human c-IAP1
Imgenex
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100 µg

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302 €

IMG-5715
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IHC  ( frozen ) , IHC  ( paraffin ) , IP, WB Erklärungen der Abkürzungen ansehen.
Rabbit SR: human
Immunogen: synthetic peptide
Imgenex
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50 µl

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267 €

IMG-5716
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IHC  ( frozen ) , IHC  ( paraffin ) , IP, WB Erklärungen der Abkürzungen ansehen.
Rabbit SR: dog, gerbil, human, mouse, rat
Immunogen: full-length recombinant human cAIP1
Imgenex
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50 µl

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302 €

IMG-5717
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IHC  ( frozen ) , IHC  ( paraffin ) , IP, WB Erklärungen der Abkürzungen ansehen.
Rabbit SR: human
Immunogen: synthetic peptide
Imgenex
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50 µl

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267 €

IMG-5824A
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Rabbit IgG SR: bovine, chimpanzee, human, mouse, rat, zebrafish
Immunogen: synthetic peptide
Imgenex
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100 µg

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302 €

IMG-6071A
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IHC  ( paraffin ) , WB Erklärungen der Abkürzungen ansehen.
Rabbit IgG SR: horse, human, monkey
Immunogen: synthetic peptide
Imgenex
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100 µg

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302 €

IMG-269
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Mouse IgG1 SR: human
Immunogen: synthetic peptide corresponding to amino acids 402-414 of human Rad18
Imgenex
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100 µg

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302 €

IMG-184A
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ChIP, IF / ICC, IHC  ( paraffin ) , IP, WB Erklärungen der Abkürzungen ansehen.
Mouse IgG1 kappa SR: human, mouse
Immunogen: bacterially expressed His-tag recombinant mouse Dnmt3b
Imgenex
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100 µg

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337 €

IMG-340
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ChIP, IP, WB Erklärungen der Abkürzungen ansehen.
Rabbit IgG SR: human, mouse
Immunogen: synthetic peptide corresponding to amino acids 1-16 of human HDAC6
Imgenex
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100 µg

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337 €

IMG-5111A
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WB Erklärungen der Abkürzungen ansehen.
WB: 0.5-2 ug/ml

Rabbit IgG SR: mouse, human, rat
Immunogen: synthetic peptide corresponding to amino acids 195-209
Imgenex
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100 µg

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302 €

IMG-306
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Mouse IgG1 SR: human
Immunogen: synthetic peptide of human MBD1
Imgenex
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100 µg

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302 €

IMG-310
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Rabbit IgG SR: human
Immunogen: synthetic peptides corresponding to amino acids 98-113 and 342-356 of human MBD1
Imgenex
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100 µg

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302 €

IMG-163A
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Mouse IgG SR: human
Imgenex
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100 µg

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337 €

IMG-296A
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Mouse IgG1 kappa SR: human
Immunogen: synthetic peptide
Imgenex
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100 µg

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337 €

IMG-5714
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IHC  ( frozen ) , IHC  ( paraffin ) , IP, WB Erklärungen der Abkürzungen ansehen.
Rabbit IgG SR: dog, gerbil, human, mouse, rat
Immunogen: recombinant protein containing the short cytoplasmic domain of the human CD40 molecule
Imgenex
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50 µl

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150 €

IMG-6078A
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Rabbit IgG SR: cow, dog, human, mouse, rat
Immunogen: synthetic peptide
Imgenex
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100 µg

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302 €

IMG-388
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Mouse IgG1 SR: mouse, human
Immunogen: synthetic peptide of human PMS2
Imgenex
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100 µg

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302 €

IMG-5142A
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Rabbit IgG SR: cow, human, mouse, rat
Immunogen: synthetic peptide corresponding to amino acids 2-16, 93% in alpha and beta
Imgenex
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100 µg

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302 €

IMG-5142A-050
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Rabbit IgG SR: human, mouse, rat
Immunogen: synthetic peptide corresponding to amino acids 2-16 of actin protein
Imgenex
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50 µg

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302 €

IMG-5985A
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Runt-related transcription factor 2 is involved in osteoblastic differentiation and skeletal morphogenesis. Essential for the maturation of osteoblasts and both intramembranous and endochondral ossification. CBF binds to the core site, 5'-PYGPYGGT-3', of a number of enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers, osteocalcin, osteopontin, bone sialoprotein, alpha 1(I) collagen, LCK, IL-3 and GM-CSF promoters. In osteoblasts, supports transcription activation: synergizes with SPEN/MINT to enhance FGFR2-mediated activation of the osteocalcin FGF-responsive element (OCFRE). It inhibits KAT6B-dependent transcriptional activation. It is specifically expressed in osteoblasts.[The UniProt Consortium]

Rabbit IgG SR: chicken, chimpanzee, horse, human, monkey, mouse
Immunogen: synthetic peptide
Imgenex
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100 µg

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302 €

IMG-6085A
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Rabbit Ig SR: bovine, human, mouse, pig, rat
Immunogen: synthetic peptide
Imgenex
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100 µg

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302 €

IMG-6142A
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DNA methyltransferase 1-associated protein 1 (DMAP1) is involved in the repression or activation of transcription.

Rabbit IgG SR: chimpanzee, cow, dog, human, mouse, rat
Immunogen: synthetic peptide
Imgenex
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100 µg

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302 €

IMG-6017A
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Rabbit IgG SR: human
Immunogen: synthetic peptide
Imgenex
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100 µg

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302 €

IMG-6083A
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WB Erklärungen der Abkürzungen ansehen.
Rabbit IgG SR: human, monkey, mouse
Immunogen: synthetic peptide
Imgenex
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100 µg

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302 €

IMG-6310A
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IHC ( paraffin ) , WB Erklärungen der Abkürzungen ansehen.
eIF3G has a RRM (RNA recognition motif) domain and is known to interact with eIF3K. The function of eIF3G is to bind to the 40S ribosomal subunit and promote the binding of methionyl-tRNAi and mRNA.

Rabbit IgG SR: chimpanzee, human, rhesus monkey
Immunogen: synthetic peptide
Imgenex
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100 µg

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302 €

IMG-6374A
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IHC ( paraffin ) , WB Erklärungen der Abkürzungen ansehen.
eIF3G is an RNA-associated protein involved in protein synthesis. It is a member of the eIF-3 subunit G family and the largest of the eukaryotic translation initiation factor family with eukaryotic translation initiation factor-3 (eIF3) being a multiprotein complex composed of at least 13 different subunits. eIF3G has a RRM (RNA recognition motif) domain and is known to interact with eIF3K. The function of eIF3G is to bind to the 40S ribosomal subunit and promote the binding of methionyl-tRNAi and mRNA. This subunit of eukaryotic translation initiation factor-3 also binds to the 18S rRNA. It is ubiquitously expressed in most tissues.

Rabbit Ig SR: chimpanzee, cow, dog, horse, human, mouse, rat, rhesus monkey
Immunogen: a portion of amino acids 200-250 of human eIF3G
Imgenex
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100 µg

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302 €

IMG-6655A
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IHC ( paraffin ) , WB Erklärungen der Abkürzungen ansehen.
High mobility group protein B1 belongs to the HMGB family and contains two HMG box DNA-binding domains. It is a highly conserved, ubiquitous protein present in the nuclei and cytoplasm of nearly all cell types, and is a necessary and sufficient mediator of inflammation during sterile and infection-associated responses. It also act as DNA nuclear binding protein that has recently been shown to be an early trigger of sterile inflammation in animal models of trauma-hemorrhage via the activation of the Toll-like receptor 4 (TLR4) and the receptor for the advanced glycation endproducts (RAGE). It is reported that the level of HMGB1 is elevated during sterile tissue injury, infection, lethal endotoxemia or sepsis, collagen-induced arthritis, and ischemia-reperfusion induced tissue injury.

Rabbit IgG SR: chicken, crow, human, monkey, mouse, rat
Immunogen: a portion of amino acids 100-150 of human HMGB1
Imgenex
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100 µg

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302 €

IMG-6666A
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IHC ( paraffin ) , WB Erklärungen der Abkürzungen ansehen.
High mobility group protein B1 belongs to the HMGB family and contains two HMG box DNA-binding domains. It is a highly conserved, ubiquitous protein present in the nuclei and cytoplasm of nearly all cell types, and is a necessary and sufficient mediator of inflammation during sterile and infection-associated responses. It also act as DNA nuclear binding protein that has recently been shown to be an early trigger of sterile inflammation in animal models of trauma-hemorrhage via the activation of the Toll-like receptor 4 (TLR4) and the receptor for the advanced glycation endproducts (RAGE). It is reported that the level of HMGB1 is elevated during sterile tissue injury, infection, lethal endotoxemia or sepsis, collagen-induced arthritis, and ischemia-reperfusion induced tissue injury.

Rabbit IgG SR: chicken, human, monkey, mouse, rat
Immunogen: a portion of amino acids 25-75 of human HMGB1
Imgenex
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100 µg

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302 €

IMG-6738A
FC ( IC ) , IHC ( paraffin ) , WB Erklärungen der Abkürzungen ansehen.
HMGB1 (high mobility group protein B1) belongs to the HMGB family and contains two HMG box DNA-binding domains. It is a highly conserved, ubiquitous protein present in the nuclei and cytoplasm of nearly all cell types, and is a necessary and sufficient mediator of inflammation during sterile and infection-associated responses. HMGB1 also act as DNA nuclear binding protein that has recently been shown to be an early trigger of sterile inflammation in animal models of trauma-hemorrhage via the activation of the Toll-like receptor 4 (TLR4) and the receptor for the advanced glycation endproducts (RAGE). It is reported that the level of HMGB1 is elevated during sterile tissue injury, infection, lethal endotoxemia or sepsis, collagen-induced arthritis, and ischemia-reperfusion induced tissue injury

Mouse IgG2b kappa SR: human, mouse
Immunogen: full-length recombinant human HMGB1
Imgenex
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100 µg

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302 €

IMG-6738E
FC ( IC ) , IHC ( paraffin ) , WB Erklärungen der Abkürzungen ansehen.
HMGB1 (high mobility group protein B1) belongs to the HMGB family and contains two HMG box DNA-binding domains. It is a highly conserved, ubiquitous protein present in the nuclei and cytoplasm of nearly all cell types, and is a necessary and sufficient mediator of inflammation during sterile and infection-associated responses. HMGB1 also act as DNA nuclear binding protein that has recently been shown to be an early trigger of sterile inflammation in animal models of trauma-hemorrhage via the activation of the Toll-like receptor 4 (TLR4) and the receptor for the advanced glycation endproducts (RAGE). It is reported that the level of HMGB1 is elevated during sterile tissue injury, infection, lethal endotoxemia or sepsis, collagen-induced arthritis, and ischemia-reperfusion induced tissue injury

Mouse IgG2b kappa SR: human, mouse
Immunogen: full-length recombinant human HMGB1
Imgenex
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100 µg

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337 €

IMG-6739A
FC ( IC ) , IHC ( paraffin ) , WB Erklärungen der Abkürzungen ansehen.
HMGB1 (high mobility group protein B1) belongs to the HMGB family and contains two HMG box DNA-binding domains. It is a highly conserved, ubiquitous protein present in the nuclei and cytoplasm of nearly all cell types, and is a necessary and sufficient mediator of inflammation during sterile and infection-associated responses. HMGB1 also act as DNA nuclear binding protein that has recently been shown to be an early trigger of sterile inflammation in animal models of trauma-hemorrhage via the activation of the Toll-like receptor 4 (TLR4) and the receptor for the advanced glycation endproducts (RAGE). It is reported that the level of HMGB1 is elevated during sterile tissue injury, infection, lethal endotoxemia or sepsis, collagen-induced arthritis, and ischemia-reperfusion induced tissue injury.

Mouse IgG1 kappa SR: human, mouse
Immunogen: full-length recombinant human HMGB1
Imgenex
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100 µg

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302 €

IMG-6740A
WB Erklärungen der Abkürzungen ansehen.
HMGB1 (high mobility group protein B1) belongs to the HMGB family and contains two HMG box DNA-binding domains. It is a highly conserved, ubiquitous protein present in the nuclei and cytoplasm of nearly all cell types, and is a necessary and sufficient mediator of inflammation during sterile and infection-associated responses. HMGB1 also act as DNA nuclear binding protein that has recently been shown to be an early trigger of sterile inflammation in animal models of trauma-hemorrhage via the activation of the Toll-like receptor 4 (TLR4) and the receptor for the advanced glycation endproducts (RAGE). It is reported that the level of HMGB1 is elevated during sterile tissue injury, infection, lethal endotoxemia or sepsis, collagen-induced arthritis, and ischemia-reperfusion induced tissue injury.

Mouse IgG2b kappa SR: human, mouse
Immunogen: full-length recombinant human HMGB1
Imgenex
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100 µg

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337 €

IMG-6476A
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OCT1/OTF1 is a protein belonging to the POU domain of transcription factors. OCT1, Octamer binding transcription factor 1, binds to an octamer motif and activates the promoters of the genes for some small nuclear RNAs (snRNA) and of genes for immunoglobulins.

Rabbit Ig SR: bovine, horse, human, mouse, rat
Immunogen: synthetic peptide (portion of amino acids 410-460 of human OCT1/OTF1)
Imgenex
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100 µg

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302 €

IMG-6501A
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IHC ( paraffin ) , WB Erklärungen der Abkürzungen ansehen.
OCT-1, Octamer binding transcription factor 1 binds to an octamer motif (5-ATTTGCAT-3) and activates the promoters of the genes for some small nuclear RNAs (snRNA) and of genes for immunoglobulins. POU domain proteins contain a bipartite DNA-binding domain, which is divided by a flexible linker that enables them to adopt various monomer configurations on DNA. The versatility of POU protein operation is conferred at the dimerization level. POU dimer from the OCT-1 gene formed on the palindromic OCT factor recognition element, or PORE, could recruit the transcriptional coactivator OBF1. This octamer sequence within immunoglobulin promoters are sufficient for lymphoid-specific promoter activity in lymphoid cells. Oct-1 regulates the expansion and/or maintenance of mature B cells. In its absence mature B-cell pull is strongly reduced.

Rabbit IgG SR: chimpanzee, dog, horse, human
Immunogen: a portion of amino acids 1-50 of human OCT-1
Imgenex
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100 µg

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302 €

IMG-465
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Rabbit IgG SR: human
Immunogen: synthetic peptides corresponding to amino acids 25-44 and 113-130 of human DUT-N
Imgenex
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200 µl

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302 €

IMG-5085
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It has recently been shown that SARS is caused by a human coronavirus. Human coronaviruses are the major cause of upper respiratory tract illness in humans, such as the common cold. Coronaviruses are positive-stranded RNA viruses, featuring the largest viral RNA genomes known to date (27-31 kb). The first step in coronavirus infection is binding of the viral spike protein, a 139-kDa protein, to certain receptors on host cells. The spike protein is the main surface antigen of the coronavirus. The most prominent protein in the culture supernatants infected with SARS virus is a 46 kDa nucleocapsid protein. This suggests that the nucleocapsid protein is a major immunogen that may be useful for early diagnostics.

Mouse IgM SR: human
Immunogen: peptide corresponding to amino acids 354-370 of human nucleocapsid protein
Imgenex
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200 µl

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418 €

IMG-302
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Mouse IgG1 SR: mouse, human
Immunogen: synthetic peptides corresponding to amino acids 136-152 and 796-812 of human DAP-5 protein
Imgenex
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100 µg

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337 €

IMG-573
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Rabbit IgG SR: human, mouse, rat
Immunogen: synthetic peptide corresponding to amino acids 39-53 of human MAPK11
Imgenex
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100 µg

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302 €

IMX-6771
Peptide ELISA Erklärungen der Abkürzungen ansehen.
Tet2 is a member of the Ten-eleven translocation encoding enzyme Tet family which oxidizes 5-methylcytosine to 5-hyroxymethylcytosine (5hmC)1. Tet2 is a 220kDa protein. Aberrancies or mutations in Tet2 have been found with frequency in human myeloid malignancies. This is a common occurrence since DNA mutilation patterns are often aberrant in cancer. Tet2 also may be an important regulator of human stem cell differentiation. Tet2 mutations have been found to delay HSC differentiation and to polarize development to the monocyte-macrophage lineage. Tet2 specific antibody provides a new tool for further characterization of epigenetic controllers of stem cell differentiation and maintenance of pluripotency.

Rabbit Ig SR: chimpanzee, human, orangutan
Immunogen: Amino acids 33-49 [KLQNGSPLPERAHPEVN] of human TET2
Imgenex
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100 µl

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220 €

IMG-5323A
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Rabbit IgG SR: human
Immunogen: synthetic peptide corresponding to amino acids 6-20 of human Rictor
Imgenex
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100 µg

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302 €

IMG-6565A
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Mili, otherwise known as Piwi-like protein 2, is an Argonaute protein, a member of the Piwi family. It is required for germ cell and stem cell development in invertebrates. Mili is essential for spermatogenesis in mouse and plays a central role during spermatogenesis by repressing transposable elements and preventing their mobilization, which is essential for the germline integrity. It is also essential for meiotic differentiation and self-renewal of spermatogonial stem cells.

Rabbit IgG SR: mouse
Immunogen: portion of amino acids 30 to 80 of mouse Mili
Imgenex
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100 µg

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302 €

IMG-6751A
IHC ( paraffin ) , WB Erklärungen der Abkürzungen ansehen.
Viperin is a 43kDa protein which is one of several hundred interferon inducible viral proteins. Elevated expression of viperin is induced by LPS and poly I:C through TLR dependent signaling pathways. Sendai virus mediated viperin expression is induced independently of TLR signaling pathways through RLRs - RIG-I and MAVs. Viperin has been shown to play an important role in interferon mediated anti-viral activity in a Hepatitis C virus model system. Viperin is induced in lymphoid cells and dendritic cells (DCs) and highly induced in neutrophils and macrophages during acute LCMV infection in mice. Viperin functions as a mediator of viral resistance and as a marker for interferon responsiveness making its detection and mechanism of action through specific antibody probes valuable for further studies. Additionally, viperin antibodies provide useful information for analysis of specific cell types responsive to interferon making it valuable for phenotyping studies complementing mechanism of action analysis.

Rabbit IgG SR: chicken, chimpanzee, chinese hamster, cow, dog, horse, human, mouse, orangutan, swine, rabbit, rat
Immunogen: synthetic peptide
Imgenex
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100 µg

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302 €

IMG-6845A
WB Erklärungen der Abkürzungen ansehen.
CADM1 (cell adhesion molecule 1) is a protein of an immunoglobulin superfamily. CADM proteins are a diverse group that consist of >100 members in vertebrates. These adhesion receptors are involved in cell/cell and cell/matrix interactions. Additionally, CADM proteins are important in differentiation, proliferation, and cell motility. Decreased or loss of function of these molecules can result in disruption to cell adhesion, sometimes resulting in metastasis. CADM1 is a putative tumour suppressor gene which is downregulated in many solid tumours. CADM1 acts as a tumor suppressor in non-small-cell lung cancer (NSCLC) cells. The cytoplasmic domain appears to play a critical role in proapoptosis and tumor suppressor activity in NSCLC. CADM1 may play diverse roles in the spermatogenesis including in the adhesion of spermatocytes and spermatids to Sertoli cells and for their normal differentiation into mature spermatozoa. CADM1 represents a promising biomarker for cancer diagnosis and a potential target for cancer therapy. It has recently been found that downregulation of CADM1 tumor suppressor gene expression is a critical event in neuroblastoma pathogenesis resulting in tumor progression and unfavourable patient outcome.

Rat IgG1 kappa SR: Chinese Hamster, dog, horse, human, mouse, pig, primate, rabbit, rat
Immunogen: Synthetic peptide
Imgenex
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100 µg

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302 €

IMG-272
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Mouse IgG1 SR: human
Immunogen: synthetic peptide corresponding amino acids 212-235 of human Rap1
Imgenex
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100 µg

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302 €

IMG-289
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Antibody detects hRap1 (TERF2IP), encoding telomeric repeat binding factor 2, interacting protein. This antibody doesn't detect endogenous hRAP1 in ICC.

Rabbit IgG SR: human
Immunogen: synthetic peptides corresponding to amino acids 212-235 of human Rap1
Imgenex
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100 µg

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302 €

IMG-339
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ChIP, IP, WB Erklärungen der Abkürzungen ansehen.
Rabbit IgG SR: human, mouse
Immunogen: synthetic peptide corresponding to amino acids 572-587 of human HDAC5
Imgenex
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100 µg

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302 €

IMG-6499A
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Period circadian protein homolog 1 (PER1) is a member of the PAS family of protein that is encoded by a Period family of genes, i.e. PER1, and is expressed in a circadian pattern in the suprachiasmatic nucleus, the primary circadian pacemaker in the mammalian brain. PER1 is a component of the circadian rhythms of locomotor activity, metabolism and behavior.

Rabbit Ig SR: chimpanzee, cow, horse, human, mouse, rat
Immunogen: a portion of amino acids 1150-1200 of human PER1
Imgenex
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100 µg

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302 €

IMG-656
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Rabbit IgG SR: human
Immunogen: synthetic peptides corresponding to amino acids 47-65 of the Anthrax LF protein (~90 kD)
Imgenex
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200 µl

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302 €

IMG-657
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Rabbit IgG SR: human
Immunogen: synthetic peptides corresponding to amino acids 290-306 of the Anthrax LF protein (~90 kD)
Imgenex
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200 µl

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302 €

IMG-658
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Rabbit IgG SR: human
Immunogen: synthetic peptides corresponding to amino acids 779-792 of the Anthrax LF protein (~90 kD)
Imgenex
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200 µl

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302 €

IMG-694
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Mouse IgG1 SR: human
Immunogen: synthetic peptide corresponding to amino acids 779-792 of the Anthrax LF protein (~90 kD)
Imgenex
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100 µg

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302 €

IMG-5133A
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Rabbit IgG SR: human
Immunogen: full length recombinant Lamin B1 from Active Motif
Imgenex
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100 µg

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302 €

IMG-6583A
IHC ( paraffin )  Erklärungen der Abkürzungen ansehen.
G1/S-specific Cyclin-D1 protein is encoded by the CCND1 gene and it belongs to the highly conserved Cyclin Family. Cyclin family members, including G1/S-specific Cyclin-D1, are characterized by a dramatic periodicity in protein abundance throughout the cell cycle. Cyclin-D1 acts as an important regulator of progression from G1 to S phase. Degradation of Cyclin-D1 results in arrest in G1 phase. Accumulation of Cyclin-D1 is regulated at multiple levels including transcription, post-translational activation and cellular localization throughout the cell cycle. Cyclin-D1 also acts to promote cell migration by inhibiting Rho/ROCK signaling and expression of thrombospondin-1 (TSP-1), an extracellular matrix protein that regulates cell migration in many settings including cancer. Mutations, amplification and overexpression of this gene, which alters cell cycle progression, are observed frequently in a variety of tumors and may contribute to tumorigenesis in humans.

Rabbit IgG SR: human
Immunogen: a portion of amino acid 250 to 300 of human CCND1
Imgenex
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100 µg

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302 €

IMG-6140A
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The CRABP2 isoform is important in retinoic acid-mediated regulation of human skin growth and differentiation. The protein is expressed in human adult liver.

Rabbit IgG SR: human, monkey
Immunogen: synthetic peptide
Imgenex
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100 µg

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302 €

IMG-370
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Rabbit IgG SR: chimpanzee, cow, human, rhesus monkey
Immunogen: synthetic peptides corresponding to amino acids 87-103 and 231-246 of human INHAT-2
Imgenex
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200 µl

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302 €

IMG-5892A
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Rabbit IgG SR: chicken, chimpanzee, dog, human, rat
Immunogen: synthetic peptide
Imgenex
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100 µg

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302 €

IMG-338
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Rabbit IgG SR: human, mouse
Immunogen: synthetic peptide corresponding to amino acids 194-209 of human HDAC4
Imgenex
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100 µg

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337 €

IMG-6308A
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IHC ( paraffin ) , WB Erklärungen der Abkürzungen ansehen.
A function of eIF3A is to bind to the 40S ribosome and promote the binding of methionyl-tRNAi and mRNA and thus stabilize the translation initiation complex. eIF3A may be required for cell division.

Rabbit Ig SR: chicken, chimpanzee, bovine, dog, horse, human, mouse, rat
Immunogen: synthetic peptide
Imgenex
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100 µg

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302 €

IMG-5710
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IHC  ( frozen ) , IHC  ( paraffin ) , IP, WB Erklärungen der Abkürzungen ansehen.
Rabbit SR: dog, gerbil, human, mouse, rat
Immunogen: synthetic peptide
Imgenex
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50 µl

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267 €

IMG-5711
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IHC  ( frozen ) , IHC  ( paraffin ) , IP, WB Erklärungen der Abkürzungen ansehen.
Rabbit SR: human
Immunogen: synthetic peptide
Imgenex
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50 µl

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267 €

IMG-5712
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IHC  ( frozen ) , IHC  ( paraffin ) , IP, WB Erklärungen der Abkürzungen ansehen.
Rabbit SR: human
Immunogen: recombinant full-length human caspase-10
Imgenex
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50 µl

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267 €

IMG-266A
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IF / ICC, WB Erklärungen der Abkürzungen ansehen.
Mouse IgG1 kappa SR: human, mouse
Immunogen: His-tag recombinant mouse Dnmt3a
Imgenex
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100 µg

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337 €

IMG-266B
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Mouse IgG1 SR: human, mouse
Immunogen: His-tag recombinant mouse Dnmt3a
Imgenex
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100 µg

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348 €

IMG-268A
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ChIP, IF / ICC, IHC  ( paraffin ) , WB Erklärungen der Abkürzungen ansehen.
Mouse IgG1 kappa SR: human, mouse
Immunogen: His-tag recombinant mouse Dnmt3a
Imgenex
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100 µg

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337 €

IMG-6465A
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Dnmt3a, also known as DNA (cytosine-5)-methyltransferase 3A, is a nuclear protein belonging to the C5-methyltransferase family with an ADD-type zinc finger and a PWWP domain. Dnmt3a localizes to euchromatin and is essential for genome wide de novo methylation and is also essential for development.

Rabbit Ig SR: chimpanzee, human, rhesus monkey
Immunogen: synthetic peptide (portion of amino acids 10-50 of human Dnmt3a)
Imgenex
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100 µg

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302 €

IMG-6466A
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Dnmt3a, also known as DNA (cytosine-5)-methyltransferase 3A, is a nuclear protein belonging to the C5-methyltransferase family with an ADD-type zinc finger and a PWWP domain. Dnmt3a localizes to euchromatin and is essential for genome wide de novo methylation and is also essential for development.

Rabbit Ig SR: cat, chicken, chimpanzee, bovine, horse, human, mouse
Immunogen: synthetic peptide (portion of amino acids 170-220 of human Dnmt3a)
Imgenex
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100 µg

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302 €

IMG-6831A
WB Erklärungen der Abkürzungen ansehen.
Methylation of DNA at cytosine residues plays an important role in regulation of gene expression, genomic imprinting and is essential for mammalian development. Hypermethylation of CpG islands in tumor suppressor genes or hypomethylation of bulk genomic DNA may be linked with development of cancer. To date, 3 families of mammalian DNA methyltransferase genes have been identified which include Dnmt1, Dnmt2 and Dnmt3. Dnmt1 is constitutively expressed in proliferating cells and inactivation of this gene causes global demethylation of genomic DNA and embryonic lethality. Dnmt2 is expressed at low levels in adult tissues and its inactivation does not affect DNA methylation or maintenance of methylation. The Dnmt3 family members, Dnmt3a and Dnmt3b, are strongly expressed in ES cells but their expression is down regulated in differentiating ES cells and is low in adult somatic tissue. Recently, it has been shown that naturally occurring mutations of Dnmt3b gene occurs in patients with a rare autosomal recessive disorder, termed ICF (immunodeficiency, centromeric instability, and facial anomalies) syndrome.

Rabbit IgG SR: human
Immunogen: synthetic peptides corresponding to amino acids 150-165 ([BLAST]GKEQKETNIESMKMEG[/BLAST]) and 175-192 ([BLAST]GWESSLRQRPMPRLTFQA[/BLAST]) of Dnmt3a.
Imgenex
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100 µg

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302 €

IMG-6316A
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WB Erklärungen der Abkürzungen ansehen.
An important role of eIF3D is the formation of the 40S initiation complex by interacting with the ternary complex of eIF2/GTP/methionyl-tRNA, and promotes mRNA binding. eIF3D is the major RNA binding subunit of the eIF3 complex.

Rabbit Ig SR: chimpanzee, human, macaque, mouse, orangutan, rat, rhesus monkey, zebrafish
Immunogen: synthetic peptide
Imgenex
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100 µg

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302 €

IMG-6504A
IHC ( paraffin )  Erklärungen der Abkürzungen ansehen.
Period circadian protein homolog 1 (PER1) is a member of the PAS family of protein that is encoded by a Period family of genes, i.e. PER1, and is expressed in a circadian pattern in the suprachiasmatic nucleus, the primary circadian pacemaker in the mammalian brain. PER1 is a component of the circadian rhythms of locomotor activity, metabolism and behavior.

Rabbit IgG SR: bovine, dog, horse, human, mouse, swine
Immunogen: portion of amino acids 30-80 of mouse PER1
Imgenex
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100 µg

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302 €

IMG-6016A
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WB Erklärungen der Abkürzungen ansehen.
IL-33 is a dual function protein that may function both as a proinflammatory cytokine and an intracellular nuclear factor with transcriptional regulatory properties.

Rabbit IgG SR: chimpanzee, human
Immunogen: synthetic peptide
Imgenex
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100 µg

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267 €

IMG-380
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WB Erklärungen der Abkürzungen ansehen.
Rabbit IgG SR: human
Immunogen: synthetic peptides of human c-Ets-1
Imgenex
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200 µl

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302 €

IMG-5841A
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Rabbit IgG SR: human
Immunogen: synthetic peptide
Imgenex
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100 µg

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302 €

IMG-5844A
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Rabbit IgG SR: bovine, human, pig
Immunogen: synthetic peptide
Imgenex
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100 µg

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302 €

IMG-576
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Rabbit IgG SR: human
Immunogen: synthetic peptide corresponding to amino acids 2-18 of human MEK-2
Imgenex
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100 µg

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302 €

IMG-291
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WB Erklärungen der Abkürzungen ansehen.
Rabbit IgG SR: human
Immunogen: synthetic peptide corresponding to amino acids 830-849 of human Stat2
Imgenex
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100 µg

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302 €

IMG-6288A
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WB Erklärungen der Abkürzungen ansehen.
eIF4A1 is a 406 amino acid ATP-dependent RNA helicase. It is a eukaryotic translation initiation factor involved in protein translation/synthesis.

Rabbit IgG SR: chimpanzee, dog, human, monkey, mouse, orangutan, rat, rhesus monkey
Immunogen: synthetic peptide
Imgenex
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100 µg

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302 €

IMG-6801A
WB Erklärungen der Abkürzungen ansehen.
AIMP1, short for Aminoacyl tRNAse synthetase complex?interacting multifunctional protein 1, is also called p43 (approx. 43 kDa molecular weight). Along with AIMP2 and AIMP3, AIMP1 is one of the three auxiliary proteins which bind to the aminoacyl tRNase synthetase complex. The AIMPs together with the Aminoacyl tRNAse synthetase, ARS, complex perform a critical role in protein synthesis but also in biological processes such as apoptosis, angiogenesis and inflammation. AIMP1 is characterized as a pleiotropic cytokine that enhances TLR1, TLR2, TLR3 and TLR7 expression in BM-DCs. AIMP1 also enhances DC production of IL-6 and IL-12 and increases NF-kappaB activity. AIMP1 has demonstrated to immune-stimulating activities as well as anti-tumor activities in mouse xenograft models. Expression AIMP1 and AIMP2 and 3 proteins are diminished in certain cancers. Overall, AIMPs may act as tumor suppressors and perhaps may be considered as a focused target for cancer treatment candidates.

MW: 43 kD
Rabbit IgG SR: cat, chinese hamster, cow, dog, guinea pig, horse, human, mole rat, mouse, new world monkey, opossum, orangutan, panda, pig, rhesus monkey, white-cheeked gibbon
Immunogen: Amino acids 720-800 from human AIMP1
Imgenex
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100 µg

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302 €

IMG-6802A
WB Erklärungen der Abkürzungen ansehen.
AIMP1, short for Aminoacyl tRNAse synthetase complex?interacting multifunctional protein 1, is also called p43 (approx. 43 kDa molecular weight). Along with AIMP2 and AIMP3, AIMP1 is one of the three auxiliary proteins which bind to the aminoacyl tRNase synthetase complex. The AIMPs together with the Aminoacyl tRNAse synthetase, ARS, complex perform a critical role in protein synthesis but also in biological processes such as apoptosis, angiogenesis and inflammation. AIMP1 is characterized as a pleiotropic cytokine that enhances TLR1, TLR2, TLR3 and TLR7 expression in BM-DCs. AIMP1 also enhances DC production of IL-6 and IL-12 and increases NF-kappaB activity. AIMP1 has demonstrated to immune-stimulating activities as well as anti-tumor activities in mouse xenograft models. Expression AIMP1 and AIMP2 and 3 proteins are diminished in certain cancers. Overall, AIMPs may act as tumor suppressors and perhaps may be considered as a focused target for cancer treatment candidates.

MW: 43 kD
Rabbit IgG SR: chimpanzee, chinese hamster, cow, elephant, guinea pig, horse, human, mole rat, mouse, orangutan, pig, rat, rhesus monkey, white-cheeked gibbon
Immunogen: Amino acids 260-310 from human AIMP1
Imgenex
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100 µg

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302 €

IMG-463
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WB Erklärungen der Abkürzungen ansehen.
Rabbit IgG SR: human
Immunogen: synthetic peptide containing Asp61 (cleavage site) of Bad
Imgenex
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200 µl

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302 €

IMG-5665
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IHC  ( frozen ) , IHC  ( paraffin ) , IP, WB Erklärungen der Abkürzungen ansehen.
Rabbit SR: human
Immunogen: synthetic peptide
Imgenex
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50 µl

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267 €

IMG-5667
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IF / ICC, IHC  ( frozen ) , IHC  ( paraffin ) , IP, WB Erklärungen der Abkürzungen ansehen.
Rabbit SR: human
Immunogen: full length recombinant protein corresponding to human Bad
Imgenex
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50 µl

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267 €

IMG-5764
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IHC  ( frozen ) , IHC  ( paraffin ) , IP, WB Erklärungen der Abkürzungen ansehen.
Rabbit SR: cow, human, mouse, rat, zebrafish
Immunogen: synthetic peptide
Imgenex
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50 µl

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267 €

IMG-5734
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IHC  ( frozen ) , IHC  ( paraffin ) , IP, WB Erklärungen der Abkürzungen ansehen.
Rabbit SR: human
Immunogen: synthetic peptide
Imgenex
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50 µl

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267 €

IMG-5735
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IHC  ( frozen ) , IHC  ( paraffin ) , IP, WB Erklärungen der Abkürzungen ansehen.
Rabbit SR: human
Immunogen: synthetic peptide
Imgenex
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50 µl

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267 €

IMG-479
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WB Erklärungen der Abkürzungen ansehen.
Rabbit IgG SR: human, mouse, rat
Immunogen: synthetic peptide corresponding to amino acids 30-46 of human SIRT5
Imgenex
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100 µg

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302 €

IMG-5899A
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Rabbit Ig SR: chimpanzee, dog, human, mouse
Immunogen: synthetic peptide
Imgenex
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100 µg

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302 €

IMG-5914A
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WB Erklärungen der Abkürzungen ansehen.
Rabbit Ig SR: chimpanzee, human, xenopus
Immunogen: synthetic peptide
Imgenex
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100 µg

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302 €

IMG-120A
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FC  ( Cell Surface ) , IF / ICC, IHC  ( paraffin ) , WB Erklärungen der Abkürzungen ansehen.
Rabbit IgG SR: human
Imgenex
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200 µl

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337 €

IMG-120E
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FC  ( Cell Surface ) , IF / ICC, IHC  ( paraffin ) , WB Erklärungen der Abkürzungen ansehen.
Rabbit IgG SR: human
Imgenex
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200 µl

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337 €

IMG-104A
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WB Erklärungen der Abkürzungen ansehen.
Rabbit SR: human
Imgenex
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100 µg

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302 €

IMG-5728
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IHC  ( frozen ) , IHC  ( paraffin ) , IP, WB Erklärungen der Abkürzungen ansehen.
Rabbit SR: human
Immunogen: synthetic peptide
Imgenex
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50 µl

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267 €

IMG-6098A
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WB Erklärungen der Abkürzungen ansehen.
FOXO3A promotes DNA repair under low stress conditions and a program of cell death under higher level of stress thus protecting quiescent cells from oxidative stress.

Rabbit IgG SR: chicken, cow, dog, human, monkey, mouse, rat
Immunogen: synthetic peptide
Imgenex
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100 µg

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302 €

IMG-555
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WB, IHC Erklärungen der Abkürzungen ansehen.
Rabbit IgG SR: human, monkey, mouse, rat
Immunogen: synthetic peptides corresponding to amino acids 85-99 and 372-388 of human Smad6
Imgenex
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200 µl

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337 €

IMG-6269A
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As a transport carrier SNX2 is involved in several stages of intracellular trafficking of proteins and also in the EGFR signaling pathway.

Rabbit Ig SR: human, monkey, mouse, rat
Immunogen: synthetic peptide
Imgenex
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100 µg

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302 €

IMG-6303A
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IHC ( paraffin ) , WB Erklärungen der Abkürzungen ansehen.
As a transport carrier Snx2 is involved in several stages of intracellular trafficking of proteins and also in the EGFR signaling pathway.

Rabbit Ig SR: chimpanzee, cow, dog, horse, human, mouse, opossum
Immunogen: synthetic peptide corresponding to amino acids 356-373
Imgenex
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100 µg

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302 €

IMG-5675
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IHC  ( frozen ) , IHC  ( paraffin ) , IP, WB Erklärungen der Abkürzungen ansehen.
Rabbit SR: human
Imgenex
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50 µl

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302 €

IMG-5676
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IHC  ( frozen ) , IHC  ( paraffin ) , IP, WB Erklärungen der Abkürzungen ansehen.
Rabbit SR: human, mouse
Immunogen: recombinant protein fragment corresponding to the C-terminal 196 amino acids of human BAG-3
Imgenex
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50 µl

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302 €

IMG-6369A
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WB Erklärungen der Abkürzungen ansehen.
REG proteins may be involved in the expansion of beta-cell mass during regeneration as well as in the maintenance of normal beta-cell function.

Rabbit IgG SR: chimpanzee, human
Immunogen: a portion of amino acids 1-50 of human Regenerating islet-derived 1
Imgenex
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100 µg

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302 €

IMG-316
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WB Erklärungen der Abkürzungen ansehen.
Rabbit IgG SR: bovine, dog, human, monkey, mouse, rat, sheep, xenopus
Immunogen: synthetic peptides of human AP-2
Imgenex
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100 µg

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302 €

IMG-6074A
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WB Erklärungen der Abkürzungen ansehen.
Rabbit IgG SR: chimpanzee, horse, human, monkey, mouse
Immunogen: synthetic peptide
Imgenex
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100 µg

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302 €

IMG-495
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Rabbit IgG SR: human
Immunogen: synthetic peptide corresponding to amino acids 51-68 of human Lig-1
Imgenex
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200 µl

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302 €

IMG-528
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IF / ICC, WB Erklärungen der Abkürzungen ansehen.
Rabbit IgG SR: human, mouse
Immunogen: synthetic peptide corresponding to amino acids 251-266 of human Nak1
Imgenex
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200 µl

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337 €

IMG-144A
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IHC  ( frozen ) , IHC  ( paraffin ) , WB Erklärungen der Abkürzungen ansehen.
Mouse IgG1 kappa SR: human, mouse, rat
Immunogen: recombinant protein of full-length human Caspase-3
Imgenex
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100 µg

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337 €

IMG-145
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WB Erklärungen der Abkürzungen ansehen.
Mouse IgG SR: human
Immunogen: 6xHis tag full-length human Caspase-3 protein
Imgenex
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100 µg

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302 €

IMG-5699
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IHC  ( frozen ) , IHC  ( paraffin ) , IP, WB Erklärungen der Abkürzungen ansehen.
Rabbit SR: gerbil, human, mouse, rat
Immunogen: recombinant full-length human Caspase-3 protein (pro-form)
Imgenex
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50 µl

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302 €

IMG-5700
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IHC  ( frozen ) , IHC  ( paraffin ) , IP, WB Erklärungen der Abkürzungen ansehen.
Rabbit SR: dog, gerbil, human, mouse, rat
Immunogen: recombinant catalytically active human caspase-3 protein
Imgenex
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50 µl

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302 €

IMG-440
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WB Erklärungen der Abkürzungen ansehen.
Mouse IgM kappa SR: human
Immunogen: synthetic peptide corresponding to amino acids 33-50 of human TIRAP
Imgenex
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100 µl

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302 €

IMG-5726
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IF / ICC, IHC  ( frozen ) , IHC  ( paraffin ) , IP, WB Erklärungen der Abkürzungen ansehen.
Rabbit SR: human
Immunogen: recombinant protein corresponding to amino acids 1279 to 1883 of human FAP-1 protein
Imgenex
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50 µl

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302 €

IMG-5727
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IHC  ( frozen ) , IHC  ( paraffin ) , IP, WB Erklärungen der Abkürzungen ansehen.
Rabbit SR: human
Immunogen: synthetic peptide
Imgenex
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50 µl

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267 €

IMG-5803A
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ELISA, IHC  ( paraffin ) , WB Erklärungen der Abkürzungen ansehen.
Rabbit Ig SR: human, mouse, rat
Immunogen: synthetic peptide
Imgenex
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IMG-6482A
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MRF2 belongs to the ARID (A-T rich interaction domain) family of transcription factors. This protein has a nonredundant function during growth and in the development of the reproductive system. MRF2 is essential for accumulation of lipid stores in postnatal life.

Rabbit IgG SR: chimpanzee, human, monkey
Immunogen: synthetic peptide (portion of amino acids 500-550 of MRF2)
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IMG-6572A
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Leucine-rich repeat FLI-I interacting protein 1 (LRRFIP1/FLAP-1) is a MyD88-interacting signal protein which mediates either induction or repression of TLR signaling. Flap-1 directly interacts with beta-catenin and activates beta-catenin-dependent transcription activity. Flap-1 or LRRFIP1 was also shown to bind the TNF- -308 promoter polymorphism site, suggesting its possible role in the regulation of TNF- production. FLAP-1 along with LRRFIP2 and FLIIH serve as a balance in coordinating inflammatory response after infection, and may act as a novel target in the control of agonist-induced TLR-mediated inflammatory and autoimmune diseases.

Rabbit IgG SR: human, mouse
Immunogen: portion of amino acid 200 to 250 of human LRRFIP1
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IMG-6422A
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STING is a signaling protein and an important component of innate immune signaling. This protein is able to activate both NF-kappa-B and IRF3 transcription pathways.

Rabbit Ig SR: human
Immunogen: synthetic peptide
Imgenex
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IMG-6485A
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STING is a 379 amino acid containing signaling protein that acts as an important component of innate immune signaling. This signaling protein is able to activate both NF-kappa-B and IRF3 transcription pathways to induce expression of type I interferon (IFN-alpha and IFN-beta) and exert a potent anti-viral state following expression. STING may have translocon function, the translocon possibly being able to influence the induction of type I interferons and is also involved in transduction of apoptotic signals via its association with the major histocompatibility complex class II (MHC-II) thus facilitating the detection of intracellular viral RNA species as well as B-form DNA and mediates death signaling via activation of the extracellular signal-regulated kinase (ERK) pathway. Generally seen in endoplasmic reticulum membrane, cell membrane and mitochondrion outer membrane, it is ubiquitously expressed in most of tissues.

Rabbit IgG SR: chimpanzee, human, mouse, rat, rhesus monkey
Immunogen: a portion of amino acids 310-360 of human STING
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IMG-6377A
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AGAP2 (also known as PIKE-A), a putative oncogene, shows elevated expression in cancer cells compared to non-transformed cells and has been implicated as regulators of cancer cell invasion into normal tissues. A contributor to brain, eye, breast and liver cancers, AGAP2 belongs to the centaurin gamma-like family with two ANK repeats, an Arf-GAP domain, a Miro domain and a PH domain. It is a GTPase-activating protein (GAP) for ARF1 and ARF5, which also shows strong GTPase activity. The Arf-GAP domain interacts with G domain and may regulate its GTPase activity. GAP activity of AGAP2 is stimulated by phosphatidylinositol 4,5-bisphosphate (PIP2) and, to a lesser extent, by phosphatidylinositol 3,4,5-trisphosphate (PIP3). Phosphatidic acid potentiates PIP2 stimulation. Several isoforms of AGAP2 have been reported.

Rabbit Ig SR: human, monkey
Immunogen: portion of amino acids 20-60 of human AGAP2
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IMG-178
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Rabbit IgG SR: human, mouse, rat
Immunogen: synthetic peptide corresponding to amino acids 233-248 of human MyD88
Imgenex
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IMG-2005-5 MyD88 Homodimerization Inhibitory Peptide
The MyD88 Homodimerization Inhibitor peptide: 5 x 1 mg (lyophilized) DRQIKIWFQN RRMKWKKRDV LPGT (m.w. 3100). Control peptide: 5 x 1 mg (lyophilized) DRQIKIWFQN RRMKWKK (m.w. 2361)
Imgenex
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IMG-6495A
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Myeloid differentiation primary response protein MyD88 is a protein which in human is encoded by the MyD88 gene. MyD88 is a universal adaptor protein which interacts with all TLRs (except TLR3) and interleukin-1 receptors (IL-1Rs) to activate the transcription factor NF-kB. Functional studies show that MyD88 is involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response and acts via IRAK1, IRAK2 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Studies suggested that MyD88-dependant TLRs and IL-1Rs are essential for protective immunity to a limited number of pyogenic bacteria and enhance the host defense to most natural infections like common viral infections.

Rabbit IgG SR: human, mouse
Immunogen: a portion of amino acids 50-100 of human MyD88 was used as Immunogen.
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IMG-5672
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IHC  ( frozen ) , IHC  ( paraffin ) , IP, WB Erklärungen der Abkürzungen ansehen.
Rabbit SR: human, mouse, rat
Imgenex
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50 µl

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IMG-5673
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IHC  ( frozen ) , IHC  ( paraffin ) , IP, WB Erklärungen der Abkürzungen ansehen.
Rabbit SR: human, mouse, rat
Immunogen: full-length recombinant human BAG-1L protein
Imgenex
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50 µl

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IMG-5114A
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WB: 1-3 ug/ml

Rabbit IgG SR: human
Immunogen: synthetic peptide corresponding to amino acids 281-297
Imgenex
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100 µg

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IMG-5115A
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WB Erklärungen der Abkürzungen ansehen.
WB: 1-3 ug/ml

Rabbit IgG SR: human
Immunogen: synthetic peptide corresponding to amino acids 47-61
Imgenex
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IMG-4009
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Protein function: Retroviral envelope proteins mediate receptor recognition and membrane fusion during early infection. Endogenous envelope proteins may have kept, lost or modified their original function during evolution. This endogenous envelope protein has retained its original fusogenic properties and participates in trophoblast fusion during placenta morphogenesis. [The UniProt Consortium]

Rabbit IgG SR: human
Immunogen: synthetic peptide (amino acids 42-50) of the HERV protein.
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IMG-247
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Rabbit IgG SR: human, mouse
Immunogen: synthetic peptide corresponding to the C-terminal amino acids 254-269 of human BLyS
Imgenex
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IMG-5659
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IHC  ( frozen ) , IHC  ( paraffin ) , IP, WB Erklärungen der Abkürzungen ansehen.
Rabbit SR: human
Immunogen: synthetic peptide
Imgenex
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50 µl

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267 €

IMG-5660
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IHC  ( frozen ) , IHC  ( paraffin ) , IP, WB Erklärungen der Abkürzungen ansehen.
Rabbit SR: human
Immunogen: synthetic peptide
Imgenex
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50 µl

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IMG-5661
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IHC  ( frozen ) , IHC  ( paraffin ) , IP, WB Erklärungen der Abkürzungen ansehen.
Rabbit SR: gerbil, human, mouse, rat
Immunogen: full-length recombinant human Apaf1 protein (amino acids 1-420)
Imgenex
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50 µl

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267 €

IMG-6081A
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WB Erklärungen der Abkürzungen ansehen.
Rabbit IgG SR: bovine, human, monkey, mouse, rat
Immunogen: synthetic peptide
Imgenex
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100 µg

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337 €

ABU010
ELISA Erklärungen der Abkürzungen ansehen.
Rabbit IgG SR: human
Immunogen: multi
Imgenex
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3 tubes

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395 €

IMG-5101A
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WB Erklärungen der Abkürzungen ansehen.
WB: 1-3 ug/ml

Rabbit IgG SR: human
Immunogen: synthetic peptide corresponding to amino acids 263-282
Imgenex
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100 µg

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IMG-6268A
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Syndecan-4 functions as a receptor or coreceptor in intracellular signaling.

Rabbit IgG SR: human, monkey, mouse
Immunogen: synthetic peptide
Imgenex
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IMG-6746A
WB, IHC Erklärungen der Abkürzungen ansehen.
This antibody will detect both isoforms of 14-3-3 sigma (248 amino acids and 169 amino acids). Protein function: Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. When bound to KRT17, regulates protein synthesis and epithelial cell growth by stimulating Akt/mTOR pathway. p53-regulated inhibitor of G2/M progression. [The UniProt Consortium]
Imgenex 100 µg

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IMG-5817A
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Rabbit IgG SR: bovine, cat, chimpanzee, dog, human
Immunogen: synthetic peptide
Imgenex
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100 µg

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IMG-5196A
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SMT3 is a Ubiquitin-like protein found in Saccharomyces cerevisiae similar to the mammalian Ubiquitin-like protein SUMO-1, which is involved in posttranslational protein modification. SMT3 is functionally active in regulation of nucleocytoplasmic transport and suggest a role in cell-cycle regulation. Knockdown of SMT3 in Drosophila in the prothoracic gland, which controls key developmental processes through the synthesis and release of ecdysteroids, caused a 4-fold prolongation of larval life and completely blocked the transition from larval to pupal stages.

Rabbit IgG SR: chimpanzee, horse, human, monkey, mouse
Immunogen: a portion of amino acids 50-95 of human SMT3
Imgenex
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100 µg

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IMG-5902A
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Rabbit IgG SR: chimpanzee, cow, dog, human, monkey, mouse, rat
Immunogen: synthetic peptide
Imgenex
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100 µg

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IMG-6884A
IHC ( paraffin ) , WB Erklärungen der Abkürzungen ansehen.
EPS8, an acronym for epidermal growth factor receptor pathways substrate 8, is a signaling protein and part of the molecular complex controlling actin reorganization. EPS8 also plays an important role in innate immunity. Through LPS activation of TLR4 and the co adaptor MyD88 protein, macrophages induce enhanced EPS8 activity typified by phagocytosis- a key innate anti-microbial defense response. EPS8 colocalizes with TLR4 in LPS activated macrophage immunocomplexes. Interestingly, EPS8 also is over expressed in malignancies including breast cancers, pancreatic cancers, and colon cancers, as examples. Antibody to EPS8 provides a tool for characterizing its functional roles in motility, adhesion, signaling pathways such as non-canonical Wnt signaling and expression in normal and neoplastic cells.

Mouse IgG2a kappa SR: human
Immunogen: Amino acids 701-882 of human EPS8 protein
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IMG-6895A
IHC ( paraffin ) , WB Erklärungen der Abkürzungen ansehen.
EPS8, an acronym for epidermal growth factor receptor pathways substrate 8, is a signaling protein and part of the molecular complex controlling actin reorganization. EPS8 also plays an important role in innate immunity. Through LPS activation of TLR4 and the co adaptor MyD88 protein, macrophages induce enhanced EPS8 activity typified by phagocytosis- a key innate anti-microbial defense response. EPS8 colocalizes with TLR4 in LPS activated macrophage immunocomplexes. Interestingly, EPS8 also is over expressed in malignancies including breast cancers, pancreatic cancers, and colon cancers, as examples. Antibody to EPS8 provides a tool for characterizing its functional roles in motility, adhesion, signaling pathways such as non-canonical Wnt signaling and expression in normal and neoplastic cells.

Mouse IgG3 kappa SR: human
Immunogen: Amino acids 701-882 of human EPS8 protein
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IMG-6498A
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Origin recognition complex subunit 1 (ORC1L) is a member of the highly conserved six subunits of the Origin Recognition Complex (ORC) which is essential for the initiation of DNA replication in eukaryotic cells. ORC complex binds specifically to origins of replication and serves as a platform for further assembly of additional transcription initiation factors such as Cdc6 and Mcm proteins. ORC1L is the largest encoded protein of the complex. Levels of this protein vary during the cell cycle, which has been shown to be controlled by Ubiquitin-mediated proteolysis after initiation of DNA replication. This protein is found to be selectively phosphorylated during mitosis. It is also reported to interact with MYST histone acetyltransferase 2 (MyST2/HBO1), a protein involved in control of transcription silencing.

Rabbit IgG SR: human, mouse
Immunogen: a portion of amino acids 170 to 220 of human ORC1L
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IMG-6529A
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Dishevelled-3 (DVL-3) is a cytoplasmic phoshoprotein that regulates cell proliferation, acting as a transducer molecule for developmental processes including segmentation and neuroblast specification in Drosophila. It is known to play a crucial role in WNT canonical signaling pathway and has been shown to be a connecting link between the Notch-WNT crosstalk. The structural and evolutionary characteristics suggest that mutations at their loci may be involved in neural and heart development defects.

Rabbit IgG SR: chimpanzee, dog, horse, human, monkey, mouse, rat, rhesus monkey
Immunogen: a portion of amino acids 560-610 of human DVL-3
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IMG-6570A
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Cell division cycle-associated 7-like protein (or RAM2) is a transcription factor which plays a role in transcriptional regulation and apoptotic signaling pathways. It acts as a repressor that inhibits monoamine oxidase A (MAOA) activity and gene expression by binding to promoter. It also plays an important oncogenic role in mediating the full transforming effect of MYC in medulloblastoma cells. It may act downstream of P38-kinase and BCL-2, but upstream of CASP3/caspase-3 as well as CCND1/cyclin D1 and E2F1

Rabbit IgG SR: chimpanzee, human, mouse
Immunogen: portion of amino acid 170 to 220 of human CDCA7L/RAM2
Imgenex
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IMG-358
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Rabbit IgG SR: human, mouse
Immunogen: synthetic peptides corresponding to amino acids 1-5 and 81-96 of human Histone H2A
Imgenex
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100 µg

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IMG-282
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Mouse IgG1 SR: human
Immunogen: synthetic peptide corresponding to amino acids 44-58 of human Tin2
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100 µg

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337 €

IMG-6807A
WB Erklärungen der Abkürzungen ansehen.
RBCK1, also known as HOIL-1L, acts as an E3 ubiquitin-protein ligase, or as part of an E3 complex that contains a zf-RanBP (Zn-finger in Ran binding protein) and a zf-C3HC4 (RING finger) domain. RBCK1 catalyzes the ubiquitination and degradation of IRF3. Both RBCK1 and IRF3 are activated by viral infections and IRF3 is a prerequisite trigger for induction of type I Interferons. RBCK1 also negatively regulates TNF and IL1 induced NF-kappaB activation. Thus it appears RBCK1 and IRF3 interaction represents a controlling antiviral regulatory channel but also that RBCK1 and ubiquitination pathways also are related to NF-kB and its role as an anti-viral response pathway.

Rabbit IgG SR: chimpanzee, human, mouse, orangutan
Immunogen: portion of amino acids 150-200 from human RBCK1
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IMG-6550A
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Lin-28 homolog A is a protein that in humans is encoded by the LIN28 gene. It is a marker of undifferentiated human embryonic stem cells and has been used to enhance the efficiency of the formation of induced pluripotent stem (iPS) cells from human fibroblasts. It encodes a cytoplasmic mRNA-binding protein that binds to and enhances the translation of the Igf2 mRNA. LIN28 has also been shown to bind to the let-7 pre-miRNA and block production of the mature let-7 microRNA in mouse embryonic stem cells.

Rabbit IgG SR: human, mouse, rat
Immunogen: a portion of amino acids 100-150 of human LIN28
Imgenex
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100 µg

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302 €

IMG-5343A
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Rabbit IgG SR: human
Immunogen: synthetic peptide
Imgenex
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100 µg

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IMG-5861A
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ZNF198 is a ubiquitously expressed nuclear protein whose physiological role is largely unknown.

Rabbit IgG SR: dog, human, monkey, orangutan
Immunogen: synthetic peptide
Imgenex
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100 µg

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IMG-5113A
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WB: 1-3 ug/ml

Rabbit IgG SR: human
Immunogen: synthetic peptide
Imgenex
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200 µl

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302 €

IMG-5846A
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WB Erklärungen der Abkürzungen ansehen.
Rabbit IgG SR: chimpanzee, human
Immunogen: synthetic peptide
Imgenex
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100 µg

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337 €

IMG-103A
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