Kontakt 0800-2466651 DE | EN Login Warenkorb



Produkttypen



Sonderbestellungen:


Spezifische Suchen:


1.843 Treffer print
ART-NR PRODUKT HERSTELLER MENGE PREIS
IMG-417D
related products

ICC, IF, FC  ( CS, IC )  Erklärungen der Abkürzungen ansehen.
Mouse IgG2a kappa SR: human
Immunogen: Ba/F3 cell line expressing human TLR4 cell surface antigen
Imgenex
Icon Datasheet
100 µg

Buy Bulk

395 €


IMG-187A
related products

WB, IP Erklärungen der Abkürzungen ansehen.
Akt1/PKBa is a serine/threonine protein kinase whose kinase activity plays a key role in cellular functions such as apoptosis, glycogen synthesis, and cell growth. Moreover, it plays a role in glucose transport by mediating insulin-induced translocation of the GLUT4 glucose transporter to the cell surface. It promotes glycogen synthesis by mediating the insulin-induced activation of glycogen synthase. Akt1/PKBa is activated by various growth factors such as platelet-derived growth factor (PDGF), epidermal growth factor (EGF), and insulin and insulin-like growth factor I (IGF-I). Defects in Akt1 are associated with breast, colorectal, and ovarian cancer. AKT phosphorylation is critical for its activity. The major phospho sites required for AKT activation have been identified as threonine 308 and serine 473. Serine 473 is phosphorylated by MAPKAP kinase 2.

Mouse IgG1 kappa SR: human, mouse
Immunogen: synthetic peptide containing phosphorylated Ser473 of human Akt1 The sequence in this region is identical in human, mouse, chicken, and frog
Imgenex
Icon Datasheet
100 µg

Buy Bulk

337 €

IMG-187E
related products

WB, IP Erklärungen der Abkürzungen ansehen.
Akt1/PKBa is a serine/threonine protein kinase whose kinase activity plays a key role in cellular functions such as apoptosis, glycogen synthesis, and cell growth. Moreover, it plays a role in glucose transport by mediating insulin-induced translocation of the GLUT4 glucose transporter to the cell surface. It promotes glycogen synthesis by mediating the insulin-induced activation of glycogen synthase. Akt1/PKBa is activated by various growth factors such as platelet-derived growth factor (PDGF), epidermal growth factor (EGF), and insulin and insulin-like growth factor I (IGF-I). Defects in Akt1 are associated with breast, colorectal, and ovarian cancer. AKT phosphorylation is critical for its activity. The major phospho sites required for AKT activation have been identified as threonine 308 and serine 473. Serine 473 is phosphorylated by MAPKAP kinase 2.

Mouse IgG1 kappa SR: human, mouse
Immunogen: synthetic peptide containing phosphorylated Ser473 of human Akt1 The sequence in this region is identical in human, mouse, chicken, and frog
Imgenex
Icon Datasheet
100 µg

Buy Bulk

348 €

IMG-487
related products

WB Erklärungen der Abkürzungen ansehen.
Rabbit IgG SR: human
Immunogen: synthetic peptide corresponding to amino acids 464-477 of human Akt1. This peptide sequence is identical in human, mouse, chicken and frog. formerly IMG-307
Imgenex
Icon Datasheet
200 µl

Buy Bulk

302 €

IMG-561
related products

WB Erklärungen der Abkürzungen ansehen.
Mouse IgG SR: human, monkey
Immunogen: synthetic peptide corresponding to amino acids 207-221 of human androgen receptor, containing the Ser213 phosphorylation site
Imgenex
Icon Datasheet
100 µg

Buy Bulk

337 €

IMG-395
related products

IHC, WB Erklärungen der Abkürzungen ansehen.
Mouse IgG1 SR: human, mouse
Immunogen: synthetic peptide corresponding to the caspase-3-induced cleavage site of human Rb
Imgenex
Icon Datasheet
100 µg

Buy Bulk

337 €

IMG-551
related products

WB Erklärungen der Abkürzungen ansehen.
Rabbit IgG SR: dog, horse, human, mouse, rat
Immunogen: synthetic peptide corresponding to amino acids 251-268 of human Rb
Imgenex
Icon Datasheet
200 µl

Buy Bulk

302 €

IMG-150A
related products

FC  ( Intracellular ) , IHC  ( paraffin ) , WB Erklärungen der Abkürzungen ansehen.
Mouse IgG1 kappa SR: human, mouse, rat
Immunogen: synthetic peptide corresponding to amino acids 526-539 of human NF-kB (p65) protein
Imgenex
Icon Datasheet
100 µg

Buy Bulk

337 €

IMG-150B
related products

WB Erklärungen der Abkürzungen ansehen.
Mouse IgG1 kappa SR: human, mouse, rat
Immunogen: synthetic peptide corresponding to amino acids 526-539 of human NF-kB (p65) protein
Imgenex
Icon Datasheet
100 µg

Buy Bulk

348 €

IMG-150E
Flow ( I ) , IHC ( paraffin ) , WB Erklärungen der Abkürzungen ansehen.
Protein function: NF-kappa-B is a pleiotropic transcription factor present in almost all cell types and is the endpoint of a series of signal transduction events that are initiated by a vast array of stimuli related to many biological processes such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52 and the heterodimeric p65-p50 complex appears to be most abundant one. [The Uniprot Consortium]

Mouse IgG1 kappa SR: human, mouse, rat
Immunogen: Synthetic peptide corresponding to amino acids 526-539 of human NF-kB (p65) protein
Imgenex
Icon Datasheet
100 µg

Buy Bulk

337 €

IMG-2001
related products

NF-​kappaB inhibition Erklärungen der Abkürzungen ansehen.
The PTD-p65 peptide can suppress NF-kB activation induced by a variety of inflammatory stimuli and NF-kB-mediated gene transcription and enhanced apoptosis induced by TNF and other apoptotic stimuli.
Imgenex
Icon Datasheet
2 mg

Buy Bulk

500 €

IMG-2003
NF-​kappaB inhibition Erklärungen der Abkürzungen ansehen.
Functions as a p65 decoy through phosphorylation of Ser529/536 sites on the peptide.
Imgenex
Icon Datasheet
2 mg

Buy Bulk

500 €

IMG-512
related products

WB Erklärungen der Abkürzungen ansehen.
Rabbit IgG SR: human, mouse, rat
Immunogen: synthetic peptide corresponding to amino acids 538-546 of human p65 (NF-kappaB subunit p65)
Imgenex
Icon Datasheet
100 µg

Buy Bulk

302 €

IMG-5915A
related products

WB Erklärungen der Abkürzungen ansehen.
Rabbit IgG SR: chimpanzee, human, monkey
Immunogen: synthetic peptide
Imgenex
Icon Datasheet
100 µg

Buy Bulk

302 €

IMG-6066A
related products

WB Erklärungen der Abkürzungen ansehen.
Rabbit Ig SR: bovine, chimpanzee, gorilla, horse, human, monkey, mouse
Immunogen: synthetic peptide
Imgenex
Icon Datasheet
100 µg

Buy Bulk

302 €

IMG-590
related products

WB Erklärungen der Abkürzungen ansehen.
Rabbit IgG SR: human
Immunogen: synthetic peptide corresponding to amino acids 324-339 of human MAPK14
Imgenex
Icon Datasheet
200 µl

Buy Bulk

302 €

IMG-6665A
related products

WB, IHC ( paraffin )  Erklärungen der Abkürzungen ansehen.
Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) catalyzes the reversible oxidative phosphorylation of glyceraldehyde-3-phosphate in the presence of inorganic phosphate and nicotinamide adenine dinucleotide (NAD), an important energy-yielding step in carbohydrate metabolism. Recent evidence suggests that it also is involved in a number of cellular processes such as membrane fusion, phosphotransferase activity, DNA replication and repair, and nuclear RNA export. GAPDH has also been implicated in playing a role in different pathologies such as cancer progression, apoptosis, and neuronal diseases such as Alzheimers and Huntingtons disease. GAPDH is constitutively expressed at high levels in almost all tissues and cell lines making it ideal for use as a loading control marker in immunoblots.

Mouse IgG1 kappa SR: chimpanzee, human, mouse, pig, rhesus monkey
Immunogen: amino acids 279-290 HQVVSSDFNSDT of glyceraldehyde 3-phosphate dehydrogenase protein
Imgenex
Icon Datasheet
100 µg

Buy Bulk

302 €

IMG-401A
related products

FC  ( Intracellular ) , WB Erklärungen der Abkürzungen ansehen.
Mouse IgG SR: human
Imgenex
Icon Datasheet
100 µg

Buy Bulk

337 €

IMG-6425A
related products

WB Erklärungen der Abkürzungen ansehen.
HSP27, also known as Heat shock 27 kDa protein, is a cytoplasmic protein in interphase cells and colocalizes with mitotic spindles in mitotic cells. It translocates to the nucleus during heat shock.

Rabbit Ig SR: chimpanzee, dog, horse, human, macaque
Immunogen: synthetic peptide
Imgenex
Icon Datasheet
20 µg

Buy Bulk

267 €

IMG-6426A
related products

WB Erklärungen der Abkürzungen ansehen.
HSP27, also known as Heat shock 27 kDa protein, is a cytoplasmic protein in interphase cells and colocalizes with mitotic spindles in mitotic cells. It translocates to the nucleus during heat shock.

Rabbit Ig SR: chimpanzee, dog, horse, human, macaque
Immunogen: synthetic peptide
Imgenex
Icon Datasheet
100 µg

Buy Bulk

302 €

IMG-5006
related products

WB Erklärungen der Abkürzungen ansehen.
Rabbit IgG SR: human
Immunogen: synthetic peptide corresponding to amino acids 366-379of human ERK1
Imgenex
Icon Datasheet
100 µg

Buy Bulk

302 €

IMG-129A
related products

FC  ( Intracellular ) , IP, WB Erklärungen der Abkürzungen ansehen.
Mouse IgG1 SR: human, mouse
Immunogen: full length human IKKbeta recombinant proetein
Imgenex
Icon Datasheet
100 µg

Buy Bulk

337 €

IMG-129AF488
FC ( IC )  Erklärungen der Abkürzungen ansehen.
NF-kB (nuclear factor kB) is sequestered in the cytoplasm by IkB family of inhibitory proteins that mask the nuclear localization signal of NF-kB thereby preventing translocation of NF-kB to the nucleus. External stimuli such as tumor necrosis factor or other cytokines results in phosphorylation and degradation of IkB releasing NF-kB dimers. NF-kB dimer subsequently translocates to the nucleus and activates target genes. Synthesis of IkBa is autoregulated. IkB proteins are phosphorylated by IkB kinase complex consisting of at least three proteins, IKK1/a, IKK2/b, and IKK3/g (3-5). IKK1/a and IKK2/b are phosphorylated by NF-kB-inducing kinase (NIK) and MAP kinase kinase kinase-1 (MEKK1), respectively. Recent studies have shown that IKK2/b, not IKK1/a, is the target proinflammatory stimuli. Targeted disruption of IKK2/b gene in mice also results in extensive liver damage from apotopsis and death as embryo.

Mouse IgG1 SR: human, mouse
Immunogen: full-length human IKKb recombinant protein
Imgenex
Icon Datasheet
100 µg

Buy Bulk

348 €

IMG-159A
related products

WB, IP Erklärungen der Abkürzungen ansehen.
Mouse IgG1 kappa SR: human, mouse
Immunogen: full length IKKb/IKK2 recombinant protein
Imgenex
Icon Datasheet
100 µg

Buy Bulk

302 €

IMG-159AF488
FC ( IC )  Erklärungen der Abkürzungen ansehen.
NF-kB (nuclear factor kB) is sequestered in the cytoplasm by IkB family of inhibitory proteins that mask the nuclear localization signal of NF-kB thereby preventing translocation of NF-kB to the nucleus. External stimuli such as tumor necrosis factor or other cytokines results in phosphorylation and degradation of IkB releasing NF-kB dimers. NF-kB dimer subsequently translocates to the nucleus and activates target genes. Synthesis of IkBa is autoregulated. IkB proteins are phosphorylated by IkB kinase complex consisting of at least three proteins, IKK1/a, IKK2/b, and IKK3/g (3-5). IKK1/a and IKK2/b are phosphorylated by NF-kB-inducing kinase (NIK) and MAP kinase kinase kinase-1 (MEKK1), respectively. Recent studies have shown that IKK2/b, not IKK1/a, is the target proinflammatory stimuli. Targeted disruption of IKK2/b gene in mice also results in extensive liver damage from apotopsis and death as embryo.

Mouse IgG1 kappa SR: human, mouse
Immunogen: full-length human IKKb/IKK2 recombinant protein
Imgenex
Icon Datasheet
100 µg

Buy Bulk

348 €

IMG-6382A
related products

WB Erklärungen der Abkürzungen ansehen.
The STAT family is a group of cytoplasmic latent transcription factors that are activated to regulate gene expression in response to a large number of extracellular signaling polypeptides including cytokines, interferons, and growth factors.

Rabbit Ig SR: chimpanzee, dog, human, mouse, rhesus monkey
Immunogen: synthetic peptide
Imgenex
Icon Datasheet
20 µg

Buy Bulk

302 €

IMG-337
related products

WB Erklärungen der Abkürzungen ansehen.
Rabbit IgG SR: human
Immunogen: synthetic peptides corresponding to amino acids 1-5, 433-448 and 467-482 of human HDAC1
Imgenex
Icon Datasheet
100 µg

Buy Bulk

302 €

IMG-360
related products

WB Erklärungen der Abkürzungen ansehen.
Rabbit IgG SR: human
Immunogen: synthetic peptide containing amino acids 41-56 of human Histone H4
Imgenex
Icon Datasheet
100 µg

Buy Bulk

302 €

IMG-6803A
related products

WB Erklärungen der Abkürzungen ansehen.
SIRT1 is a nuclear protein and member of the sirtuin protein family of deacetylating proteins. SIRT1 is involved in regulating a number of cellular pathways including apoptosis and cell senescence, longevity and aging. Not surprisingly, SIRT1 targets to forkhead (FOXO) transcription factors. SIRT1 physically binds to the p65/RelA protein in the NF-kappaB complex and inhibits the transcriptional activity by deacetylating the p65 component. SIRT1 anti-inflammatory responses have also been demonstrated using resveratrol, a potent activator of SIRT1, which has been shown to potentiate the SIRT1-mediated anti-inflammatory response.

Rabbit IgG SR: cat, chicken, chimpanzee, chinese hamster, cow, dog, frog, horse, human, monkey, mouse, orangutan, pig, rabbit
Immunogen: portion of amino acids 400-450 from human SIRT1
Imgenex
Icon Datasheet
100 µg

Buy Bulk

302 €

IMG-261A
related products

ChIP, IHC  ( paraffin ) , WB Erklärungen der Abkürzungen ansehen.
Mouse IgG1 kappa SR: human, mouse, zebrafish
Immunogen: synthetic peptide corresponding to amino acids 637-651 of human Dnmt1
Imgenex
Icon Datasheet
100 µg

Buy Bulk

337 €

IMG-6311A
related products

IHC ( paraffin ) , WB Erklärungen der Abkürzungen ansehen.
H3.3 constitutes the predominant form of histone H3 in non-dividing cells and is incorporated into chromatin independently of DNA synthesis.

Rabbit IgG SR: chicken, bovine, drosophila, horse, human, mouse, opossum
Immunogen: synthetic peptide
Imgenex
Icon Datasheet
100 µg

Buy Bulk

302 €

IMG-5848A
related products

WB Erklärungen der Abkürzungen ansehen.
Rabbit IgG SR: bovine, dog, human, mouse, pig, rat, rhesus monkey
Immunogen: synthetic peptide
Imgenex
Icon Datasheet
100 µg

Buy Bulk

302 €

IMG-463
related products

WB Erklärungen der Abkürzungen ansehen.
Rabbit IgG SR: human
Immunogen: synthetic peptide containing Asp61 (cleavage site) of Bad
Imgenex
Icon Datasheet
200 µl

Buy Bulk

302 €

IMG-5665
related products

IHC  ( frozen ) , IHC  ( paraffin ) , IP, WB Erklärungen der Abkürzungen ansehen.
Rabbit SR: human
Immunogen: synthetic peptide
Imgenex
Icon Datasheet
50 µl

Buy Bulk

267 €

IMG-5667
related products

IF / ICC, IHC  ( frozen ) , IHC  ( paraffin ) , IP, WB Erklärungen der Abkürzungen ansehen.
Rabbit SR: human
Immunogen: full length recombinant protein corresponding to human Bad
Imgenex
Icon Datasheet
50 µl

Buy Bulk

267 €

IMG-280
related products

WB Erklärungen der Abkürzungen ansehen.
Rabbit IgG SR: chimpanzee, dog, human, mouse, pig
Immunogen: synthetic peptides of human STAT1
Imgenex
Icon Datasheet
100 µg

Buy Bulk

302 €

IMG-351
related products

WB Erklärungen der Abkürzungen ansehen.
Mouse IgM SR: human
Immunogen: synthetic peptides of human Akt2
Imgenex
Icon Datasheet
200 µl

Buy Bulk

302 €

IMG-421
related products

WB Erklärungen der Abkürzungen ansehen.
Rabbit IgG SR: human
Immunogen: synthetic peptides of human Akt2
Imgenex
Icon Datasheet
200 µl

Buy Bulk

302 €

IMG-6213A
Peptide ELISA Erklärungen der Abkürzungen ansehen.
The 70 kDa ribosomal S6 kinase, p70S6K1, is a serine/threonine kinase that functions as a downstream target of the phosphatidylinositol 3-kinase (PI3K)/AKT and mitogen-activated protein (MAP) kinase signaling pathways. p70S6K1 mediates several effects of the PI3K/AKT pathway, including cellular transformation. The protein is also involved in neuronal cell differentiation, cell cycle progression and promotes the G1 phase of the cell cycle in response to growth factors. The protein has been implicated in inducing actin filament remodeling, an essential process for cell migration. Recent data suggests that the protein regulates the expression of an oncoprotein, HDM2, thus mediating tumor growth. Human p70S6K1 gene is localized in the chromosomal region 17q23.1. The protein is widely expressed and exists in two isoforms: a 70 kDa cytoplasmic form and a 85 kDa nuclear form.

Goat Ig SR: bovine, human, mouse, rabbit, rat
Immunogen: amino acids 512-525 of human p70S6K1
Imgenex
Icon Datasheet
100 µl

Buy Bulk

302 €

IMG-5816A
related products

WB Erklärungen der Abkürzungen ansehen.
Rabbit IgG SR: bovine, chicken, chimpanzee, dog, human, mouse, rat
Immunogen: synthetic peptide
Imgenex
Icon Datasheet
100 µg

Buy Bulk

302 €

IMG-5685
related products

IHC  ( frozen ) , IHC  ( paraffin ) , IP, WB Erklärungen der Abkürzungen ansehen.
Rabbit SR: cat, dog, human
Immunogen: synthetic peptide
Imgenex
Icon Datasheet
50 µl

Buy Bulk

267 €

IMG-5686
related products

IHC  ( frozen ) , IHC  ( paraffin ) , IP, WB Erklärungen der Abkürzungen ansehen.
Rabbit SR: cat, dog, human
Immunogen: synthetic peptide
Imgenex
Icon Datasheet
50 µl

Buy Bulk

267 €

IMG-5689
related products

IHC  ( frozen ) , IHC  ( paraffin ) , IP, WB Erklärungen der Abkürzungen ansehen.
Rabbit SR: human
Immunogen: synthetic peptide
Imgenex
Icon Datasheet
50 µl

Buy Bulk

267 €

IMG-2004
p50 decoy', blocking NLS recognition Erklärungen der Abkürzungen ansehen.
Imgenex
Icon Datasheet
2 mg

Buy Bulk

500 €

IMG-5812A
related products

WB Erklärungen der Abkürzungen ansehen.
Mouse IgG1 kappa SR: human
Immunogen: synthetic peptide
Imgenex
Icon Datasheet
100 µg

Buy Bulk

337 €

IMG-297A
related products

WB Erklärungen der Abkürzungen ansehen.
Rabbit IgG SR: human
Imgenex
Icon Datasheet
100 µg

Buy Bulk

302 €

IMG-326
related products

WB Erklärungen der Abkürzungen ansehen.
Mouse IgG1 SR: human, mouse, rat
Immunogen: synthetic peptide corresponding to amino acids 119-136 of human Akt3
Imgenex
Icon Datasheet
100 µg

Buy Bulk

302 €

IMG-355
related products

WB Erklärungen der Abkürzungen ansehen.
Rabbit IgG SR: human, mouse, rat
Immunogen: synthetic peptide corresponding to amino acids 119-136 of human Akt3
Imgenex
Icon Datasheet
200 µl

Buy Bulk

302 €

IMG-6133A
related products

WB Erklärungen der Abkürzungen ansehen.
Rabbit Ig SR: chicken, chimpanzee, cow, dog, drosophila, human, mouse, rat
Immunogen: synthetic peptide
Imgenex
Icon Datasheet
50 µg

Buy Bulk

348 €

IMG-6134A
related products

WB Erklärungen der Abkürzungen ansehen.
MEK1 and MEK2 are integral components of the MAP kinase cascade that regulates cell growth and differentiation and this pathway also plays a key role in synaptic plasticity in brain.

Rabbit Ig SR: chicken, chimpanzee, cow, dog, drosophila, human, mouse, rat
Immunogen: synthetic peptide
Imgenex
Icon Datasheet
100 µg

Buy Bulk

302 €

IMG-5023
related products

WB Erklärungen der Abkürzungen ansehen.
Rabbit IgG SR: human
Immunogen: synthetic peptide corresponding to amino acids 2-16 & 157-170
Imgenex
Icon Datasheet
100 µg

Buy Bulk

302 €

IMG-5347A
related products

WB Erklärungen der Abkürzungen ansehen.
Rabbit IgG SR: human, mouse, rat
Immunogen: synthetic peptide corresponding to amino acids 110-124 of human AIK1
Imgenex
Icon Datasheet
100 µg

Buy Bulk

302 €

IMG-5341A
related products

WB Erklärungen der Abkürzungen ansehen.
Rabbit IgG SR: human, mouse
Immunogen: synthetic peptide corresponding to amino acids 560-576 of human MSH2 protein
Imgenex
Icon Datasheet
100 µg

Buy Bulk

302 €

IMG-164
related products

IF / ICC, IHC  ( paraffin ) , IP, WB Erklärungen der Abkürzungen ansehen.
Mouse IgG SR: human
Immunogen: GST fusion protein of human full length Rad9
Imgenex
Icon Datasheet
100 µg

Buy Bulk

337 €

IMG-424
related products

WB Erklärungen der Abkürzungen ansehen.
Rabbit IgG SR: human, mouse
Immunogen: synthetic peptide corresponding to amino acids 19-35 & 564-579
Imgenex
Icon Datasheet
100 µg

Buy Bulk

302 €

IMG-5859A
related products

WB Erklärungen der Abkürzungen ansehen.
BRD4 belongs to the BET family of nuclear proteins that carry 2 bromodomains and an additional ET domain. BRD4 acts at different stages of cell cycle by interacting with proteins including RFC and SPA-1 and regulates cell growth.

Rabbit IgG SR: chimpanzee, human, mouse, rat
Immunogen: synthetic peptide
Imgenex
Icon Datasheet
100 µg

Buy Bulk

302 €

IMG-336A
related products

WB Erklärungen der Abkürzungen ansehen.
Mouse IgG1 SR: human
Imgenex
Icon Datasheet
100 µg

Buy Bulk

302 €

IMG-336E
WB Erklärungen der Abkürzungen ansehen.
Chk2 (checkpoint kinase 2) is the mammalian homolog of the Saccharomyces cerevisiae Rad53 and is required for the DNA damage and replication checkpoints. In response to low-dose ionizing radiation (IR), which occurs in an ataxia telangiectasia mutated (ATM)-dependent manner, Chk2 can phosphorylate the mitosis-inducing phosphatase Cdc25C on an inhibitory site, blocking entry into mitosis, and p53 on a regulatory site, causing G1 arrest. In human tissues, Chk2 is homogeneously expressed in renewing cell populations such as epidermis or intestine, heterogeneous in conditionally renewing tissues, and absent or at low level in static tissues such as muscle or brain. Mutations in Chk2 inactivates DNA damage checkpoint pathway involving Chk2 in lung cancer suggesting that reduced expression of Chk2 may be responsible for the development of lung cancer. The Chk2-/- knockout cells are resistant to DNA damage-induced apoptosis, defective for p53 stabilization and for induction of p53-dependent transcripts such as p21 in response to gamma irradiation.

Mouse IgG1 SR: human
Immunogen: A portion of amino acids 100-150 of human Chk2 protein
Imgenex
Icon Datasheet
100 µg

Buy Bulk

337 €

IMG-5822A
related products

WB Erklärungen der Abkürzungen ansehen.
Rabbit IgG SR: bovine, broad, chicken, chimpanzee, dog, human, monkey
Immunogen: synthetic peptide
Imgenex
Icon Datasheet
100 µg

Buy Bulk

302 €

IMG-5823A
related products

WB Erklärungen der Abkürzungen ansehen.
Rabbit IgG SR: bovine, broad, chimpanzee, dog, human, monkey
Immunogen: synthetic peptide
Imgenex
Icon Datasheet
100 µg

Buy Bulk

302 €

IMG-5297A
related products

WB Erklärungen der Abkürzungen ansehen.
Rabbit Ig SR: bovine, dog, human, monkey, mouse, pig, rat, rhesus monkey
Immunogen: synthetic peptide 140 - 153
Imgenex
Icon Datasheet
200 µl

Buy Bulk

302 €

IMG-311
related products

WB Erklärungen der Abkürzungen ansehen.
Rabbit IgG SR: human
Immunogen: synthetic peptide corresponding to amino acids 13-27
Imgenex
Icon Datasheet
100 µg

Buy Bulk

302 €

IMG-350A
related products

WB Erklärungen der Abkürzungen ansehen.
Mouse IgG1 SR: human
Immunogen: synthetic peptide containing phosphorylated Thr71 of human ATF-2
Imgenex
Icon Datasheet
100 µg

Buy Bulk

348 €

IMG-2000
related products

NF-​kappaB inhibition Erklärungen der Abkürzungen ansehen.
This cell permeable IKKgamma (NEMO) binding peptide prevents formation of IKK complex formation, thereby inhibiting NF-kB activation.
Imgenex
Icon Datasheet
2 mg

Buy Bulk

500 €

IMG-287A
related products

WB Erklärungen der Abkürzungen ansehen.
Mouse IgG1 SR: human
Imgenex
Icon Datasheet
100 µg

Buy Bulk

302 €

IMG-324A
related products

WB Erklärungen der Abkürzungen ansehen.
Mouse IgG1 SR: human, mouse
Immunogen: His-tagged full length human IKK3/IKKg protein
Imgenex
Icon Datasheet
100 µg

Buy Bulk

302 €

IMG-324B
related products

ELISA, WB Erklärungen der Abkürzungen ansehen.
Mouse IgG1 kappa SR: human, mouse
Immunogen: His-tagged full length human IKK3/IKKg protein
Imgenex
Icon Datasheet
100 µg

Buy Bulk

348 €

IMG-127A
related products

WB, IP Erklärungen der Abkürzungen ansehen.
Mouse IgG1 kappa SR: human, mouse
Immunogen: recombinant protein corresponding to amino acids 32-391 of human IKBa
Imgenex
Icon Datasheet
100 µg

Buy Bulk

337 €

IMG-127B
related products

WB, ELISA Erklärungen der Abkürzungen ansehen.
Mouse IgG1 kappa SR: human, mouse
Immunogen: recombinant protein corresponding to amino acids 32-391 of human IKBa
Imgenex
Icon Datasheet
100 µg

Buy Bulk

348 €

IMG-156A
related products

WB, IP, ELISA Erklärungen der Abkürzungen ansehen.
Mouse IgG1 kappa SR: human, mouse
Immunogen: synthetic peptide containing phosphorylated Ser32 and Ser36 of human IkBa
Imgenex
Icon Datasheet
100 µg

Buy Bulk

337 €

IMG-156B
related products

WB, IP, ELISA Erklärungen der Abkürzungen ansehen.
Mouse IgG1 kappa SR: human, mouse
Immunogen: synthetic peptide containing phosphorylated Ser32 and Ser36 of human IkBa
Imgenex
Icon Datasheet
100 µg

Buy Bulk

348 €

IMG-394
related products

WB Erklärungen der Abkürzungen ansehen.
Mouse IgG1 SR: human
Immunogen: synthetic peptide corresponding to the caspase-3 med cleavage site
Imgenex
Icon Datasheet
100 µg

Buy Bulk

337 €

IMG-5016
related products

WB Erklärungen der Abkürzungen ansehen.
Rabbit IgG SR: human
Immunogen: synthetic peptide corresponding to amino acids 34-48 of human IkBalpha
Imgenex
Icon Datasheet
100 µl

Buy Bulk

302 €

IMG-5270A
related products

WB Erklärungen der Abkürzungen ansehen.
Does not react with mouse I-kappa-B-alpha.

Rabbit IgG SR: human
Immunogen: full length recombinant protein
Imgenex
Icon Datasheet
100 µg

Buy Bulk

302 €

IMG-514
related products

WB Erklärungen der Abkürzungen ansehen.
Rabbit IgG SR: human
Immunogen: synthetic peptide corresponding to amino acids 249-266 of human Lamin A/C
Imgenex
Icon Datasheet
100 µg

Buy Bulk

302 €

IMG-5228A
related products

WB, IHC Erklärungen der Abkürzungen ansehen.
Rabbit IgG SR: human
Immunogen: synthetic peptide
Imgenex
Icon Datasheet
100 µg

Buy Bulk

302 €

IMG-5664
related products

IHC  ( frozen ) , IHC  ( paraffin ) , IP, WB Erklärungen der Abkürzungen ansehen.
Rabbit SR: human
Immunogen: synthetic peptide
Imgenex
Icon Datasheet
50 µl

Buy Bulk

267 €

IMX-6097
ELISA Erklärungen der Abkürzungen ansehen.
It is a receptor that binds to peroxisome proliferators such as hypolipidemic drugs and fatty acids and controls the peroxisomal beta-oxidation pathway of fatty acids. It is thus a key regulator of adipocyte differentiation and glucose homeostasis.

Rabbit Ig SR: horse, human, monkey, mouse, rat
Immunogen: synthetic peptide
Imgenex
Icon Datasheet
100 µl

Buy Bulk

220 €

IMG-162
related products

WB Erklärungen der Abkürzungen ansehen.
Mouse IgG SR: human
Immunogen: fusion protein corresponding to amino acids 205 to 222 of human TRAF2
Imgenex
Icon Datasheet
100 µg

Buy Bulk

337 €

IMG-5759
related products

IHC  ( frozen ) , IHC  ( paraffin ) , IP, WB Erklärungen der Abkürzungen ansehen.
Rabbit SR: human, mouse, rat
Immunogen: synthetic peptide
Imgenex
Icon Datasheet
50 µl

Buy Bulk

267 €

IMG-5760
related products

IHC  ( frozen ) , IHC  ( paraffin ) , IP, WB Erklärungen der Abkürzungen ansehen.
Rabbit SR: human
Immunogen: synthetic peptide
Imgenex
Icon Datasheet
50 µl

Buy Bulk

267 €

IMG-5682
related products

IHC  ( frozen ) , IHC  ( paraffin ) , IP, WB Erklärungen der Abkürzungen ansehen.
Rabbit SR: human
Immunogen: synthetic peptide
Imgenex
Icon Datasheet
50 µl

Buy Bulk

267 €

IMG-382
related products

WB Erklärungen der Abkürzungen ansehen.
Mouse IgG1 kappa SR: human
Immunogen: synthetic peptide of human MLH-1
Imgenex
Icon Datasheet
100 µg

Buy Bulk

302 €

IMG-6857A
WB, IHC Erklärungen der Abkürzungen ansehen.
SGK1, an acronym for serum and glucocorticoid regulated kinase, appears to be important for intrauterine embryo implantation and pregnancy maintenance along with a variety of other pathways such as neuronal excitation, renal sodium ion secretion, apoptosis and T-cell signaling.

Rabbit IgG SR: broad
Immunogen: A portion of amino acids 360-410 from human SGK1
Imgenex
Icon Datasheet
100 µg

Buy Bulk

302 €

IMG-5723
related products

IHC  ( frozen ) , IHC  ( paraffin ) , IP, WB Erklärungen der Abkürzungen ansehen.
Rabbit IgG SR: cow, dog, human, monkey, rat
Immunogen: synthetic peptide corresponding to amino acids 272-291 of human DAXX
Imgenex
Icon Datasheet
50 µl

Buy Bulk

267 €

IMG-5770
related products

IHC  ( frozen ) , IHC  ( paraffin ) , IP, WB Erklärungen der Abkürzungen ansehen.
Rabbit SR: gerbil, human, mouse, rat
Immunogen: recombinant BIR2 domain protein fragment of human XIAP
Imgenex
Icon Datasheet
50 µl

Buy Bulk

302 €

IMG-5771
related products

IHC  ( frozen ) , IHC  ( paraffin ) , IP, WB Erklärungen der Abkürzungen ansehen.
Rabbit SR: gerbil, human, mouse, rat
Immunogen: recombinant BIR2 domain protein fragment of human XIAP
Imgenex
Icon Datasheet
50 µl

Buy Bulk

267 €

IMG-5772
related products

IHC  ( frozen ) , IHC  ( paraffin ) , IP, WB Erklärungen der Abkürzungen ansehen.
Rabbit SR: gerbil, human, mouse, rat
Immunogen: recombinant BIR2 domain protein fragment of human XIAP
Imgenex
Icon Datasheet
50 µl

Buy Bulk

267 €

IMG-5773
related products

IHC  ( frozen ) , IHC  ( paraffin ) , IP, WB Erklärungen der Abkürzungen ansehen.
Rabbit SR: gerbil, human, mouse, rat
Immunogen: recombinant BIR2 domain protein fragment of human XIAP
Imgenex
Icon Datasheet
50 µl

Buy Bulk

267 €

IMG-5774
related products

IHC  ( frozen ) , IHC  ( paraffin ) , IP, WB Erklärungen der Abkürzungen ansehen.
Rabbit SR: human
Immunogen: synthetic peptide
Imgenex
Icon Datasheet
50 µl

Buy Bulk

267 €

IMG-247
related products

WB Erklärungen der Abkürzungen ansehen.
Rabbit IgG SR: human, mouse
Immunogen: synthetic peptide corresponding to the C-terminal amino acids 254-269 of human BLyS
Imgenex
Icon Datasheet
100 µg

Buy Bulk

302 €

IMG-6009A
related products

WB Erklärungen der Abkürzungen ansehen.
Rabbit Ig SR: cow, dog, horse, human, monkey
Immunogen: synthetic peptide
Imgenex
Icon Datasheet
100 µg

Buy Bulk

302 €

IMG-5808A
related products

WB Erklärungen der Abkürzungen ansehen.
Rabbit IgG SR: chimpanzee, human
Immunogen: synthetic peptide
Imgenex
Icon Datasheet
100 µg

Buy Bulk

150 €

IMG-5916A
FA  ( Neutr. ) , FC  ( Cell Surface ) , IHC Erklärungen der Abkürzungen ansehen.
Mouse IgG1 kappa SR: human
Imgenex
Icon Datasheet
100 µg

Buy Bulk

150 €

IMG-5916C
FA  ( Neutr. ) , FC  ( Cell Surface ) , IHC Erklärungen der Abkürzungen ansehen.
Mouse IgG1 kappa SR: human
Imgenex
Icon Datasheet
100 tests

Buy Bulk

220 €

IMG-5916D
FA  ( Neutr. ) , FC  ( Cell Surface ) , IHC Erklärungen der Abkürzungen ansehen.
Mouse IgG1 kappa SR: human
Imgenex
Icon Datasheet
100 tests

Buy Bulk

220 €

IMG-5916E
FA ( Neutralization ) , FC ( CS ) , IHC ( cryosections )  Erklärungen der Abkürzungen ansehen.
CD4 may regulate T-cell activation. It plays a more general role in mediating cell recognition events than merely those of cellular immune response.

Mouse IgG1 kappa SR: human
Imgenex
Icon Datasheet
100 µg

Buy Bulk

115 €

IMG-5916G
FA  ( Neutr. ) , FC  ( Cell Surface ) , IHC Erklärungen der Abkürzungen ansehen.
Mouse IgG1 kappa SR: human
Imgenex
Icon Datasheet
100 Tests

Buy Bulk

220 €

IMG-136A
related products

WB, IP Erklärungen der Abkürzungen ansehen.
Mouse IgG1 kappa SR: human, monkey, mouse
Immunogen: His-tagged full length human IKKa/IKK1 protein
Imgenex
Icon Datasheet
100 µg

Buy Bulk

337 €

IMG-136AF488
FC ( IC )  Erklärungen der Abkürzungen ansehen.
NF-kB (nuclear factor kB) is sequestered in the cytoplasm by IkB family of inhibitory proteins that mask the nuclear localization signal of NF-kB thereby preventing translocation of NF-kB to the nucleus. External stimuli such as tumor necrosis factor or other cytokines results in phosphorylation and degradation of IkB releasing NF-kB dimers. NF-kB dimer subsequently translocates to the nucleus and activates target genes. Synthesis of IkBa is autoregulated. IkB proteins are phosphorylated by IkB kinase complex consisting of at least three proteins, IKK1/a, IKK2/b, and IKK3/g. In vitro, IKK1/a and IKK2/b can form homo- and heterodimers that can phosphorylate IkBs at the regulatory serine residues directly. IKK1/a and IKK2/b are phosphorylated by NF-kB-inducing kinase (NIK) and MAP kinase kinase kinase-1 (MEKK1), respectively. Targeted disruption of IKK1/a gene in mice results in skin and limb abnormalities and death of newborns (2,3).

Mouse IgG1 kappa SR: human, monkey, mouse
Immunogen: His-tagged full-length human IKKa/IKK1 protein
Imgenex
Icon Datasheet
100 µg

Buy Bulk

348 €

IMG-6111A
related products

WB Erklärungen der Abkürzungen ansehen.
Rabbit Ig SR: chicken, chimpanzee, human, monkey
Immunogen: synthetic peptide
Imgenex
Icon Datasheet
100 µl

Buy Bulk

302 €

IMG-2011set
TLR4 inhibition Erklärungen der Abkürzungen ansehen.
Set contains 1 mg each of VIPER and CP7 (control peptide). VIPER (viral inhibitory peptide of TLR4) is a TLR4 specific inhibitory peptide that potentently inhibits TLR4-mediated responses and is inert towards other TLR pathways (Bowie et al. 2010, Lysakova-Devine et al. 2010). VIPER consists of an 11 amino acid (KYSFKLILAEY)inhibitory sequence, derived from the A46 vaccinia virus protein, linked to a 9R (RRRRRRRRR) homopolymer delivery sequence. VIPER interferes with the interaction between TLR4 and its adaptor proteins Mal and TRAM. It is thought that VIPER inhibits TLR4 signaling by binding to the TIR domains of Mal and TRAM. Since TIR domains engage the MAl and TRAM adaptor proteins with TLR4, blocking adaptor TIR domains with VIPER would disrupt propagation of the TLR4 signal. However, the exact mechanism by which VIPER inhibits TLR4 signaling remains to be fully elucidated. Likewise, the specific VIPER binding sites on TRAM and Mal TIR domains remain to be identified.
Imgenex
Icon Datasheet
1 set

Buy Bulk

395 €

IMG-2204-1
TLR4 activation Erklärungen der Abkürzungen ansehen.
TLR4 recognizes LPS, a major cell wall component of gram-negative bacteria that activates the innate immune system. Recognition of LPS requires CD14 in addition to TLR4. The responsiveness of the TLR4 and CD14 complex to LPS is enhanced by MD2.
Imgenex
Icon Datasheet
1 mg

Buy Bulk

139 €

IMG-417A
related products

FC  ( CCS, IC ) , IF / ICC, IP Erklärungen der Abkürzungen ansehen.
Mouse IgG2a kappa SR: human
Immunogen: Ba/F3 cell line expressing human TLR4 cell surface antigen
Imgenex
Icon Datasheet
100 µg

Buy Bulk

337 €

IMG-417AF488
related products

ICC, IF, FC  ( CS, IC )  Erklärungen der Abkürzungen ansehen.
Mouse IgG2a kappa SR: mouse
Immunogen: Ba/F3 cell line expressing human TLR4 cell surface antigen
Imgenex
Icon Datasheet
100 µg

Buy Bulk

395 €

IMG-417B
related products

ELISA, IP, ICC, FC Erklärungen der Abkürzungen ansehen.
Mouse IgG2a kappa SR: dog, human
Immunogen: Ba/F3 cell line expressing human TLR4 cell surface antigen
Imgenex
Icon Datasheet
100 µg

Buy Bulk

348 €

IMG-417C
related products

ICC, IF, FC  ( CS, IC )  Erklärungen der Abkürzungen ansehen.
Mouse IgG2a kappa SR: dog, human
Immunogen: Ba/F3 cell line expressing human TLR4 cell surface antigen
Imgenex
Icon Datasheet
100 µg

Buy Bulk

395 €

IMG-417E
related products

FA  ( Neutr. ) , FC  ( CS, IC ) , IF, ICC, IP Erklärungen der Abkürzungen ansehen.
Mouse IgG2a SR: human
Immunogen: Ba/F3 cell line expressing human TLR4 cell surface antigen
Imgenex
Icon Datasheet
100 µg

Buy Bulk

348 €

IMG-5031A
related products

FC  ( Cell Surface ) , WB Erklärungen der Abkürzungen ansehen.
Mouse IgG2b kappa SR: human, mouse, rat
Immunogen: synthetic peptide corresponding to amino acids 125-140 of human TLR4
Imgenex
Icon Datasheet
100 µg

Buy Bulk

337 €

IMG-5031AF647
FC ( CS ) , FC ( IC )  Erklärungen der Abkürzungen ansehen.
The Toll-like receptor (TLR) family in mammal comprises a family of transmembrane proteins characterized by multiple copies of leucine rich repeats in the extracellular domain and IL-1 receptor motif in the cytoplasmic domain. Like its counterparts in Drosophila, TLRs signal through adaptor molecules. The TLR family is a phylogenetically conserved mediator of innate immunity that is essential for microbial recognition. Ten human homologs of TLRs (TLR1-10) have been described. Among this family of receptors, TLR2 and TLR4 have been most studied. These studies have suggested that TLR2 and TLR4 may serve as potential main mediators of LPS signaling (4,5). The TLR4 cDNA codes for a protein consisting of 799 amino acids with approximate molecular weight of 88 kDa.

Mouse IgG2b kappa SR: human, mouse, rat
Immunogen: a portion of amino acids 100-200 of human TLR4
Imgenex
Icon Datasheet
100 µg

Buy Bulk

395 €

IMG-5031C
FC  ( Cell Surface )  Erklärungen der Abkürzungen ansehen.
Mouse IgG2b kappa SR: human, mouse, rat
Immunogen: synthetic peptide (amino acids 125-140)
Imgenex
Icon Datasheet
100 µg

Buy Bulk

348 €

IMG-577
related products

WB, IP Erklärungen der Abkürzungen ansehen.
Rabbit IgG SR: human, mouse
Immunogen: synthetic peptide corresponding to amino acids 706-728
Imgenex
Icon Datasheet
100 µg

Buy Bulk

302 €

IMG-579A
related products

IHC  ( paraffin ) , WB Erklärungen der Abkürzungen ansehen.
Rabbit IgG SR: human, mouse
Immunogen: synthetic peptide corresponding to amino acids 418-435
Imgenex
Icon Datasheet
100 µg

Buy Bulk

302 €

IMG-579AF488
FC  ( CS )  Erklärungen der Abkürzungen ansehen.
The Toll-like receptor (TLR) family in mammal comprises a family of transmembrane proteins characterized by multiple copies of leucine rich repeats in the extracellular domain and IL-1 receptor motif in the cytoplasmic domain. Like its counterparts in Drosophila, TLRs signal through adaptor molecules. The TLR family is a phylogenetically conserved mediator of innate immunity that is essential for microbial recognition. Ten human homologs of TLRs (TLR1-10) have been described. Among this family of receptors, TLR2 and TLR4 have been most studied. These studies have suggested that TLR2 and TLR4 may serve as potential main mediators of LPS signaling. The mouse TLR4 cDNA codes for a protein consisting of 839 amino acids with approximate molecular weight of 90 kDa.

Rabbit IgG SR: human, mouse
Immunogen: Synthetic peptide corresponding to amino acids 420-435 of human TLR4.
Imgenex
Icon Datasheet
100 µg

Buy Bulk

348 €

IMG-6276A
related products

WB Erklärungen der Abkürzungen ansehen.
Studies have suggested that TLR2 and TLR4 may serve as potential main mediators of LPS signaling.

Rabbit Ig SR: human, mouse, rat
Immunogen: synthetic phospho-peptide
Imgenex
Icon Datasheet
20 µg

Buy Bulk

348 €

IMG-6285A
related products

WB Erklärungen der Abkürzungen ansehen.
TLR4 is involved in signal transduction events induced by LPS. TLR4 mediates the production of cytokines necessary for the development of effective immunity.

Rabbit Ig SR: baboon, chimpanzee, human, macaque, rhesus monkey
Immunogen: synthetic peptide
Imgenex
Icon Datasheet
100 µg

Buy Bulk

302 €

IMG-6307A
related products

WB Erklärungen der Abkürzungen ansehen.
The TLR family is a phylogenetically conserved mediator of innate immunity that is essential for microbial recognition. Multiple studies have suggested that TLR2 and TLR4 may serve as potential main mediators of LPS signaling.

Rabbit Ig SR: bison, chimpanzee, bovine, gorilla, horse, human, macaque
Immunogen: synthetic peptide
Imgenex
Icon Datasheet
100 µg

Buy Bulk

302 €

IML-104
Agonist screening, functional assays Erklärungen der Abkürzungen ansehen.
Stably co-transfected cell line which expresses human Toll-like receptor 4 (TLR4) and the secreted alkaline phosphatase (SEAP) reporter gene under the transcriptional control of an NF-kappaB response element.
Imgenex
Icon Datasheet
1 each

Buy Bulk

1223 €

IML-104MD2CD14
Agonist / antagonist screening, functional assays Erklärungen der Abkürzungen ansehen.
Content: 3-4 x 10e6 cells. TLR4/MD-2/NF-kappaB/SEAPorterTM HEK 293 is a stably co-transfected cell line which expresses full-length human Toll-like receptor 4 (TLR4), human MD-2 and secreted alkaline phosphatase (SEAP) reporter genes under the transcriptional control of an NF-kappaB response element. The cell line has been validated by a ligand dose response assay and can be used for TLR4-dependent functional assays as well as screening of TLR4 agonists or antagonists.
Imgenex
Icon Datasheet
1 each

Buy Bulk

1338 €

IML-204
FC calibration, control Erklärungen der Abkürzungen ansehen.
TLR4/HEK 293 is a stably transfected cell line which expresses full-length human Toll-like receptor 4 (TLR4) with an N-terminal HA tag.
Imgenex
Icon Datasheet
1 each

Buy Bulk

947 €

IMG-5898A
related products

WB Erklärungen der Abkürzungen ansehen.
Rabbit IgG SR: chimpanzee, human, monkey, mouse
Immunogen: synthetic peptide
Imgenex
Icon Datasheet
100 µg

Buy Bulk

302 €

IMG-5903A
related products

WB Erklärungen der Abkürzungen ansehen.
Rabbit IgG SR: dog, human, monkey
Immunogen: synthetic peptide
Imgenex
Icon Datasheet
100 µg

Buy Bulk

302 €

IMG-481
related products

WB Erklärungen der Abkürzungen ansehen.
Mouse IgG1 SR: human
Immunogen: synthetic peptide containing amino acid residues of human lck protein
Imgenex
Icon Datasheet
100 µg

Buy Bulk

302 €

IMG-5142A
related products

WB Erklärungen der Abkürzungen ansehen.
Rabbit IgG SR: cow, human, mouse, rat
Immunogen: synthetic peptide corresponding to amino acids 2-16, 93% in alpha and beta
Imgenex
Icon Datasheet
100 µg

Buy Bulk

302 €

IMG-5142A-025
related products
neu

WB Erklärungen der Abkürzungen ansehen.
Rabbit IgG SR: human, mouse, rat
Immunogen: synthetic peptide corresponding to amino acids 2-16 of actin protein
Imgenex
Icon Datasheet
25 µg

Buy Bulk

150 €

IMG-5142A-050
related products

WB Erklärungen der Abkürzungen ansehen.
Rabbit IgG SR: human, mouse, rat
Immunogen: synthetic peptide corresponding to amino acids 2-16 of actin protein
Imgenex
Icon Datasheet
50 µg

Buy Bulk

302 €

IMG-537
related products

IHC  ( paraffin ) , WB Erklärungen der Abkürzungen ansehen.
Rabbit IgG SR: human, mouse, rat
Immunogen: synthetic peptide corresponding to amino acids 328-338 of human CXCR4
Imgenex
Icon Datasheet
100 µg

Buy Bulk

302 €

IMG-537E
related products

IHC  ( paraffin ) , WB Erklärungen der Abkürzungen ansehen.
Rabbit IgG SR: human, mouse, rat
Imgenex
Icon Datasheet
100 µg

Buy Bulk

302 €

IMG-6823A
WB Erklärungen der Abkürzungen ansehen.
IL-1beta (Interleukin-1 beta, IL-1b) is a potent inflammatory cytokine which has been well studied. Produced as a precursor, especially in myeloid cells and monocytes/macrophages, IL-1beta is processed by cleavage with caspase-1, or ICE, from the 31 kD inactive precursor to the 18kD active mature form secreted from cells as an end-result of the inflammasome complex and activation sequence. In response to various TLR ligands, myeloid cells or macrophages activate NLRP3 inflammasomes and secrete IL-1beta. The rate of IL-1beta processing has been correlated to redox state or levels of ROS generated. IL-1beta is directly involved in a variety of diseases -auto-inflammatory diseases, acute inflammatory attacks such as ischemic injury in myocardial infarcts or in chronic inflammatory processes of atherosclerosis or Type 2 diabetes. The ability to detect and quantitate active IL-1beta is critical for understanding how to regulate its activity as a therapeutic target.

Mouse IgG1 kappa SR: human
Immunogen: Full-length recombinant human IL-1beta
Imgenex
Icon Datasheet
100 µg

Buy Bulk

302 €

IMG-6826A
WB Erklärungen der Abkürzungen ansehen.
IL-1beta (Interleukin-1 beta, IL-1b) is a potent inflammatory cytokine which has been well studied. Produced as a precursor, especially in myeloid cells and monocytes/macrophages, IL-1beta is processed by cleavage with caspase-1, or ICE, from the 31 kD inactive precursor to the 18kD active mature form secreted from cells as an end-result of the inflammasome complex and activation sequence. In response to various TLR ligands, myeloid cells or macrophages activate NLRP3 inflammasomes and secrete IL-1beta. The rate of IL-1beta processing has been correlated to redox state or levels of ROS generated. IL-1beta is directly involved in a variety of diseases -?auto-inflammatory diseases, acute inflammatory attacks such as ischemic injury in myocardial infarcts or in chronic inflammatory processes of atherosclerosis or Type 2 diabetes. The ability to detect and quantitate active IL-1beta is critical for understanding how to regulate its activity as a therapeutic target

Mouse IgG1 kappa SR: human
Immunogen: Full-length recombinant human IL-1beta protein
Imgenex
Icon Datasheet
100 µg

Buy Bulk

302 €

IMG-6827A
WB Erklärungen der Abkürzungen ansehen.
IL-1beta (Interleukin-1 beta, IL-1b) is a potent inflammatory cytokine which has been well studied. Produced as a precursor, especially in myeloid cells and monocytes/macrophages, IL-1 beta is processed by cleavage with caspase-1, or ICE, from the 31 kD inactive precursor to the 18kD active mature form secreted from cells as an end-result of the inflammasome complex and activation sequence. In response to various TLR ligands, myeloid cells or macrophages activate NLRP3 inflammasomes and secrete IL-1 beta. The rate of IL-1 beta processing has been correlated to redox state or levels of ROS generated. IL-1 beta is directly involved in a variety of diseases -auto-inflammatory diseases, acute inflammatory attacks such as ischemic injury in myocardial infarcts or in chronic inflammatory processes of atherosclerosis or Type 2 diabetes. The ability to detect and quantitate active IL-1 beta is critical for understanding how to regulate its activity as a therapeutic target.

Mouse IgG1 kappa SR: human
Immunogen: Full-length recombinant human IL-1 beta protein
Imgenex
Icon Datasheet
100 µg

Buy Bulk

302 €

IMG-6828A
WB Erklärungen der Abkürzungen ansehen.
IL-1beta (Interleukin-1 beta, IL-1beta) is a potent inflammatory cytokine which has been well studied. Produced as a precursor, especially in myeloid cells and monocytes/macrophages, IL-1b is processed by cleavage with caspase-1, or ICE, from the 31 kD inactive precursor to the 18kD active mature form secreted from cells as an end-result of the inflammasome complex and activation sequence. In response to various TLR ligands, myeloid cells or macrophages activate NLRP3 inflammasomes and secrete IL-1b. The rate of IL-1b processing has been correlated to redox state or levels of ROS generated. IL-1b is directly involved in a variety of diseases -auto-inflammatory diseases, acute inflammatory attacks such as ischemic injury in myocardial infarcts or in chronic inflammatory processes of atherosclerosis or Type 2 diabetes. The ability to detect and quantitate active IL-1b is critical for understanding how to regulate its activity as a therapeutic target.

Mouse IgG1 kappa SR: human
Immunogen: Full-length recombinant human IL-1b protein
Imgenex
Icon Datasheet
100 µg

Buy Bulk

302 €

IMG-6830A
FC  ( IC ) , IHC  ( paraffin ) , WB Erklärungen der Abkürzungen ansehen.
IL-1beta (Interleukin-1 beta, IL-1b) is a potent inflammatory cytokine which has been well studied. Produced as a precursor, especially in myeloid cells and monocytes/macrophages, Interleukin-1 beta is processed by cleavage with caspase-1, or ICE, from the 31 kD inactive precursor to the 18kD active mature form secreted from cells as an end-result of the inflammasome complex and activation sequence. In response to various TLR ligands, myeloid cells or macrophages activate NLRP3 inflammasomes and secrete Interleukin-1 beta. The rate of Interleukin-1 beta processing has been correlated to redox state or levels of ROS generated. Interleukin-1 beta is directly involved in a variety of diseases -auto-inflammatory diseases, acute inflammatory attacks such as ischemic injury in myocardial infarcts or in chronic inflammatory processes of atherosclerosis or Type 2 diabetes. The ability to detect and quantitate active Interleukin-1 beta is critical for understanding how to regulate its activity as a therapeutic target.

Mouse IgG1 kappa SR: human
Immunogen: Full-length recombinant human Interleukin-1 beta protein
Imgenex
Icon Datasheet
100 µg

Buy Bulk

302 €

IMG-373
related products

WB Erklärungen der Abkürzungen ansehen.
Rabbit IgG SR: human, mouse
Immunogen: synthetic peptide corresponding to amino acids 231-245 of human AML-1 (homologous in AML-1/ETO)
Imgenex
Icon Datasheet
100 µg

Buy Bulk

337 €

IMP-123
hRUNX1 expression Erklärungen der Abkürzungen ansehen.
Mammalian expression vector construct, pCMV/hRUNX1, containing coding sequence of human Runt-related transcription factor 1 (GenBank Accession: BC136381)
Imgenex
Icon Datasheet
10 µg

Buy Bulk

500 €

IMG-271A
related products

WB Erklärungen der Abkürzungen ansehen.
Mouse IgG1 SR: human
Immunogen: synthetic peptide
Imgenex
Icon Datasheet
100 µg

Buy Bulk

302 €

IMG-271B
ELISA Erklärungen der Abkürzungen ansehen.
WB: 2-4 ug/ml

Mouse IgG1 kappa SR: human
Immunogen: synthetic peptide of human CREB
Imgenex
Icon Datasheet
100 µg

Buy Bulk

337 €

IMG-392
related products

WB Erklärungen der Abkürzungen ansehen.
Rabbit IgG SR: human
Immunogen: synthetic peptides corresponding to amino acids 36-52 and 216-232 of human APE
Imgenex
Icon Datasheet
100 µg

Buy Bulk

302 €

IMG-6655A
related products

IHC ( paraffin ) , WB Erklärungen der Abkürzungen ansehen.
High mobility group protein B1 belongs to the HMGB family and contains two HMG box DNA-binding domains. It is a highly conserved, ubiquitous protein present in the nuclei and cytoplasm of nearly all cell types, and is a necessary and sufficient mediator of inflammation during sterile and infection-associated responses. It also act as DNA nuclear binding protein that has recently been shown to be an early trigger of sterile inflammation in animal models of trauma-hemorrhage via the activation of the Toll-like receptor 4 (TLR4) and the receptor for the advanced glycation endproducts (RAGE). It is reported that the level of HMGB1 is elevated during sterile tissue injury, infection, lethal endotoxemia or sepsis, collagen-induced arthritis, and ischemia-reperfusion induced tissue injury.

Rabbit IgG SR: chicken, crow, human, monkey, mouse, rat
Immunogen: a portion of amino acids 100-150 of human HMGB1
Imgenex
Icon Datasheet
100 µg

Buy Bulk

302 €

IMG-6666A
related products

IHC ( paraffin ) , WB Erklärungen der Abkürzungen ansehen.
High mobility group protein B1 belongs to the HMGB family and contains two HMG box DNA-binding domains. It is a highly conserved, ubiquitous protein present in the nuclei and cytoplasm of nearly all cell types, and is a necessary and sufficient mediator of inflammation during sterile and infection-associated responses. It also act as DNA nuclear binding protein that has recently been shown to be an early trigger of sterile inflammation in animal models of trauma-hemorrhage via the activation of the Toll-like receptor 4 (TLR4) and the receptor for the advanced glycation endproducts (RAGE). It is reported that the level of HMGB1 is elevated during sterile tissue injury, infection, lethal endotoxemia or sepsis, collagen-induced arthritis, and ischemia-reperfusion induced tissue injury.

Rabbit IgG SR: chicken, human, monkey, mouse, rat
Immunogen: a portion of amino acids 25-75 of human HMGB1
Imgenex
Icon Datasheet
100 µg

Buy Bulk

302 €

IMG-6738A
FC ( IC ) , IHC ( paraffin ) , WB Erklärungen der Abkürzungen ansehen.
HMGB1 (high mobility group protein B1) belongs to the HMGB family and contains two HMG box DNA-binding domains. It is a highly conserved, ubiquitous protein present in the nuclei and cytoplasm of nearly all cell types, and is a necessary and sufficient mediator of inflammation during sterile and infection-associated responses. HMGB1 also act as DNA nuclear binding protein that has recently been shown to be an early trigger of sterile inflammation in animal models of trauma-hemorrhage via the activation of the Toll-like receptor 4 (TLR4) and the receptor for the advanced glycation endproducts (RAGE). It is reported that the level of HMGB1 is elevated during sterile tissue injury, infection, lethal endotoxemia or sepsis, collagen-induced arthritis, and ischemia-reperfusion induced tissue injury

Mouse IgG2b kappa SR: human, mouse
Immunogen: full-length recombinant human HMGB1
Imgenex
Icon Datasheet
100 µg

Buy Bulk

302 €

IMG-6738E
FC ( IC ) , IHC ( paraffin ) , WB Erklärungen der Abkürzungen ansehen.
HMGB1 (high mobility group protein B1) belongs to the HMGB family and contains two HMG box DNA-binding domains. It is a highly conserved, ubiquitous protein present in the nuclei and cytoplasm of nearly all cell types, and is a necessary and sufficient mediator of inflammation during sterile and infection-associated responses. HMGB1 also act as DNA nuclear binding protein that has recently been shown to be an early trigger of sterile inflammation in animal models of trauma-hemorrhage via the activation of the Toll-like receptor 4 (TLR4) and the receptor for the advanced glycation endproducts (RAGE). It is reported that the level of HMGB1 is elevated during sterile tissue injury, infection, lethal endotoxemia or sepsis, collagen-induced arthritis, and ischemia-reperfusion induced tissue injury

Mouse IgG2b kappa SR: human, mouse
Immunogen: full-length recombinant human HMGB1
Imgenex
Icon Datasheet
100 µg

Buy Bulk

337 €

IMG-6739A
FC ( IC ) , IHC ( paraffin ) , WB Erklärungen der Abkürzungen ansehen.
HMGB1 (high mobility group protein B1) belongs to the HMGB family and contains two HMG box DNA-binding domains. It is a highly conserved, ubiquitous protein present in the nuclei and cytoplasm of nearly all cell types, and is a necessary and sufficient mediator of inflammation during sterile and infection-associated responses. HMGB1 also act as DNA nuclear binding protein that has recently been shown to be an early trigger of sterile inflammation in animal models of trauma-hemorrhage via the activation of the Toll-like receptor 4 (TLR4) and the receptor for the advanced glycation endproducts (RAGE). It is reported that the level of HMGB1 is elevated during sterile tissue injury, infection, lethal endotoxemia or sepsis, collagen-induced arthritis, and ischemia-reperfusion induced tissue injury.

Mouse IgG1 kappa SR: human, mouse
Immunogen: full-length recombinant human HMGB1
Imgenex
Icon Datasheet
100 µg

Buy Bulk

302 €

IMG-6740A
WB Erklärungen der Abkürzungen ansehen.
HMGB1 (high mobility group protein B1) belongs to the HMGB family and contains two HMG box DNA-binding domains. It is a highly conserved, ubiquitous protein present in the nuclei and cytoplasm of nearly all cell types, and is a necessary and sufficient mediator of inflammation during sterile and infection-associated responses. HMGB1 also act as DNA nuclear binding protein that has recently been shown to be an early trigger of sterile inflammation in animal models of trauma-hemorrhage via the activation of the Toll-like receptor 4 (TLR4) and the receptor for the advanced glycation endproducts (RAGE). It is reported that the level of HMGB1 is elevated during sterile tissue injury, infection, lethal endotoxemia or sepsis, collagen-induced arthritis, and ischemia-reperfusion induced tissue injury.

Mouse IgG2b kappa SR: human, mouse
Immunogen: full-length recombinant human HMGB1
Imgenex
Icon Datasheet
100 µg

Buy Bulk

337 €

IMG-139A
related products

WB Erklärungen der Abkürzungen ansehen.
Mouse IgG1 kappa SR: cow, dog, human, mouse, rat
Immunogen: synthetic peptide
Imgenex
Icon Datasheet
100 µg

Buy Bulk

337 €

IMG-270A
related products

WB Erklärungen der Abkürzungen ansehen.
This antibody detects both, IKKi/IKke as well as TBK1.

Mouse IgG2a kappa SR: human, mouse, rat
Immunogen: synthetic peptide corresponding to amino acids 175-188 of human IKKi/e protein
Imgenex
Icon Datasheet
100 µg

Buy Bulk

337 €

IMG-179
related products

WB, IP Erklärungen der Abkürzungen ansehen.
Rabbit IgG SR: human, mouse
Immunogen: synthetic peptide corresponding to amino acids 700 to 712 of human IRAK
Imgenex
Icon Datasheet
100 µg

Buy Bulk

302 €

IMG-5754
related products

IHC  ( frozen ) , IHC  ( paraffin ) , IP, WB Erklärungen der Abkürzungen ansehen.
Rabbit SR: gerbil, human, mouse, rat
Immunogen: full-length recombinant human survivin protein
Imgenex
Icon Datasheet
50 µl

Buy Bulk

267 €

IMG-5755
related products

IHC  ( frozen ) , IHC  ( paraffin ) , IP, WB Erklärungen der Abkürzungen ansehen.
Rabbit SR: gerbil, human, mouse, rat
Immunogen: full-length recombinant human survivin protein
Imgenex
Icon Datasheet
50 µl

Buy Bulk

267 €

IMG-6082A
related products

WB Erklärungen der Abkürzungen ansehen.
Rabbit IgG SR: human
Immunogen: synthetic peptide
Imgenex
Icon Datasheet
100 µg

Buy Bulk

302 €

IMG-6383A
related products

WB Erklärungen der Abkürzungen ansehen.
Rabbit Ig SR: chicken, chimpanzee, dog, human, mouse, rat, zebrafish
Immunogen: portion of human Paxillin protein containing a phosphorylated tyrosine at position 118
Imgenex
Icon Datasheet
100 µl

Buy Bulk

302 €

IMG-274A
related products

WB Erklärungen der Abkürzungen ansehen.
Mouse IgG1 SR: human
Immunogen: synthetic peptide corresponding to amino acids 217-222 of human caspase-8
Imgenex
Icon Datasheet
100 µg

Buy Bulk

337 €

IMG-274B
related products

WB Erklärungen der Abkürzungen ansehen.
Mouse IgG1 kappa SR: human
Immunogen: synthetic peptide corresponding to amino acids 217-222 of human caspase-8
Imgenex
Icon Datasheet
100 µg

Buy Bulk

302 €

IMG-5703
related products

IHC  ( frozen ) , IHC  ( paraffin ) , IP, WB Erklärungen der Abkürzungen ansehen.
Rabbit SR: gerbil, human, mouse, rat
Immunogen: recombinant catalytically active human Caspase-8 protein
Imgenex
Icon Datasheet
50 µl

Buy Bulk

302 €

IMG-5704
related products

IHC  ( frozen ) , IHC  ( paraffin ) , IP, WB Erklärungen der Abkürzungen ansehen.
Rabbit SR: gerbil, human, mouse, rat
Immunogen: synthetic peptide
Imgenex
Icon Datasheet
50 µl

Buy Bulk

267 €

IMG-6897A
WB Erklärungen der Abkürzungen ansehen.
Matrix metallopeptidase 2 (also known as MMP2, gelatinase A, 72kDa gelatinase, and 72kDa type IV collagenase) belongs to a family of mammalian extracellular neutral metalloproteinases that are able to degrade a number of matrix proteins. MMP-2 degrades type IV collagen, the structural component of basement membranes, in a specific manner, and it also has gelatinase activity. The protein also plays a role in endometrial menstrual breakdown, regulation of vascularization and the inflammatory response. The pathological role of the protein has been observed in multicentric osteolysis nodulosis and arthropathy and Winchester syndrome.

Rabbit IgG SR: cat, chimpanzee, dog, horse, human, orangutan
Immunogen: A portion of amino acids 550-600 of human MMP2
Imgenex
Icon Datasheet
100 µg

Buy Bulk

302 €

IMG-582
related products

WB Erklärungen der Abkürzungen ansehen.
Rabbit IgG SR: human, mouse
Immunogen: synthetic peptide corresponding to amino acids 525-540 of human Bcl-6
Imgenex
Icon Datasheet
100 µg

Buy Bulk

302 €

IMG-565
related products

WB Erklärungen der Abkürzungen ansehen.
Rabbit IgG SR: human, monkey, mouse, rat
Immunogen: synthetic peptide corresponding to amino acids 186-199 & 509-523 of human Smad4
Imgenex
Icon Datasheet
200 µl

Buy Bulk

302 €

IMG-5322A
related products

WB Erklärungen der Abkürzungen ansehen.
Rabbit Ig SR: mouse, human
Immunogen: synthetic peptide 925-940
Imgenex
Icon Datasheet
200 µl

Buy Bulk

337 €

IMG-536
related products

WB Erklärungen der Abkürzungen ansehen.
Rabbit IgG SR: human, mouse
Immunogen: synthetic peptide corresponding to amino acids 436-449 of human TRAF6. TRAF6 = Tumor Necrosis factor (TNF) associated Factor 6
Imgenex
Icon Datasheet
200 µl

Buy Bulk

302 €

IMG-5766
related products

IHC  ( frozen ) , IHC  ( paraffin ) , IP, WB Erklärungen der Abkürzungen ansehen.
Rabbit SR: cow, human, mouse, rat
Immunogen: synthetic peptide
Imgenex
Icon Datasheet
50 µl

Buy Bulk

302 €

IMG-6291A
related products

WB Erklärungen der Abkürzungen ansehen.
PKD2 is a calcium independent, phospholipid dependent, protein kinase. It helps in controlling phorbol ester binding, catalytic activity, and nucleocytoplasmic shuttling.

Rabbit IgG SR: chimpanzee, dog, horse, human, mouse, opossum, rat
Immunogen: synthetic peptide
Imgenex
Icon Datasheet
100 µg

Buy Bulk

302 €

IMG-6313A
related products

IHC ( paraffin ) , WB Erklärungen der Abkürzungen ansehen.
TIP60 is a catalytic subunit of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes. TIP60 has a role in DNA repair and apoptosis and is thought to play an important role in signal transduction.

Rabbit IgG
Immunogen: synthetic peptide corresponding to amino acids 499-512
Imgenex
Icon Datasheet
100 µg

Buy Bulk

302 €

IMG-6583A
IHC ( paraffin )  Erklärungen der Abkürzungen ansehen.
G1/S-specific Cyclin-D1 protein is encoded by the CCND1 gene and it belongs to the highly conserved Cyclin Family. Cyclin family members, including G1/S-specific Cyclin-D1, are characterized by a dramatic periodicity in protein abundance throughout the cell cycle. Cyclin-D1 acts as an important regulator of progression from G1 to S phase. Degradation of Cyclin-D1 results in arrest in G1 phase. Accumulation of Cyclin-D1 is regulated at multiple levels including transcription, post-translational activation and cellular localization throughout the cell cycle. Cyclin-D1 also acts to promote cell migration by inhibiting Rho/ROCK signaling and expression of thrombospondin-1 (TSP-1), an extracellular matrix protein that regulates cell migration in many settings including cancer. Mutations, amplification and overexpression of this gene, which alters cell cycle progression, are observed frequently in a variety of tumors and may contribute to tumorigenesis in humans.

Rabbit IgG SR: human
Immunogen: a portion of amino acid 250 to 300 of human CCND1
Imgenex
Icon Datasheet
100 µg

Buy Bulk

302 €

IMG-144A
related products

IHC  ( frozen ) , IHC  ( paraffin ) , WB Erklärungen der Abkürzungen ansehen.
Mouse IgG1 kappa SR: human, mouse, rat
Immunogen: recombinant protein of full-length human Caspase-3
Imgenex
Icon Datasheet
100 µg

Buy Bulk

337 €

IMG-145
related products

WB Erklärungen der Abkürzungen ansehen.
Mouse IgG SR: human
Immunogen: 6xHis tag full-length human Caspase-3 protein
Imgenex
Icon Datasheet
100 µg

Buy Bulk

302 €

IMG-5699
related products

IHC  ( frozen ) , IHC  ( paraffin ) , IP, WB Erklärungen der Abkürzungen ansehen.
Rabbit SR: gerbil, human, mouse, rat
Immunogen: recombinant full-length human Caspase-3 protein (pro-form)
Imgenex
Icon Datasheet
50 µl

Buy Bulk

302 €

IMG-5700
related products

IHC  ( frozen ) , IHC  ( paraffin ) , IP, WB Erklärungen der Abkürzungen ansehen.
Rabbit SR: dog, gerbil, human, mouse, rat
Immunogen: recombinant catalytically active human caspase-3 protein
Imgenex
Icon Datasheet
50 µl

Buy Bulk

302 €

IMG-6061A
related products

WB Erklärungen der Abkürzungen ansehen.
LC3A, a mammalian homolog of yeast Atg8, plays an essential role in autophagy, leading to bulk degradation of cytoplasmic components by the lysosomal system where it acts as an adaptor protein between microtubules and autophagosomes.

Rabbit Ig SR: cow, human, opossum, rat, zebrafish
Immunogen: synthetic peptide corresponding to amino acids 1-15
Imgenex
Icon Datasheet
100 µg

Buy Bulk

302 €

IMG-6077A
related products

IHC  ( paraffin ) , WB Erklärungen der Abkürzungen ansehen.
Rabbit IgG SR: cow, human, monkey, opossum, rat
Immunogen: synthetic peptide
Imgenex
Icon Datasheet
100 µg

Buy Bulk

337 €

IMG-426
related products

WB Erklärungen der Abkürzungen ansehen.
Rabbit IgG SR: human
Immunogen: synthetic peptides corresponding to amino acids 31-46 and 94-110 of human TMS1
Imgenex
Icon Datasheet
100 µg

Buy Bulk

302 €

IMG-5662
related products

IHC  ( frozen ) , IHC  ( paraffin ) , IP, WB Erklärungen der Abkürzungen ansehen.
Rabbit SR: human
Immunogen: synthetic peptide
Imgenex
Icon Datasheet
50 µl

Buy Bulk

302 €

IMG-6016A
related products

WB Erklärungen der Abkürzungen ansehen.
IL-33 is a dual function protein that may function both as a proinflammatory cytokine and an intracellular nuclear factor with transcriptional regulatory properties.

Rabbit IgG SR: chimpanzee, human
Immunogen: synthetic peptide
Imgenex
Icon Datasheet
100 µg

Buy Bulk

267 €

IMG-6085A
related products

WB Erklärungen der Abkürzungen ansehen.
Rabbit Ig SR: bovine, human, mouse, pig, rat
Immunogen: synthetic peptide
Imgenex
Icon Datasheet
100 µg

Buy Bulk

302 €

IMG-575
related products

WB Erklärungen der Abkürzungen ansehen.
Rabbit IgG SR: human
Immunogen: synthetic peptide corresponding to amino acids 372-390 of human MST-1
Imgenex
Icon Datasheet
100 µg

Buy Bulk

302 €

IMG-5842A
related products

WB Erklärungen der Abkürzungen ansehen.
Rabbit IgG SR: dog, human, mouse, rat, rhesus monkey, zebrafish
Immunogen: synthetic peptide
Imgenex
Icon Datasheet
100 µg

Buy Bulk

302 €

IMG-5887A
related products

WB Erklärungen der Abkürzungen ansehen.
Rabbit IgG SR: dog, human, mouse, rat, rhesus monkey
Immunogen: synthetic peptide
Imgenex
Icon Datasheet
100 µg

Buy Bulk

302 €

IMG-6033A
related products

WB Erklärungen der Abkürzungen ansehen.
Rabbit IgG SR: chimpanzee, cow, dog, human, monkey, mouse
Immunogen: synthetic peptide
Imgenex
Icon Datasheet
100 µg

Buy Bulk

302 €

IMG-6361A
related products

WB Erklärungen der Abkürzungen ansehen.
LSD1, a novel and first known lysine-specific histone demethylase, nuclear protein belonging to the flavin monoamine oxidase family with a SWIRM domain, a FAD-binding motif, and an amine oxidase domain. LSD1, a component of several histone deacetylase complexes, is ubiquitously expressed in most of the tissues. A component of the CoREST and other transcriptional co-repressor complexes, LSD1 is known to play an important role in silencing neuronal-specific genes in non-neuronal cells. It is also known to demethylate Lys-4 of histone H3, a specific tag for epigenetic transcriptional activation. Reports suggest that it plays an important role in stimulating androgen-receptor-dependent transcription converting oxygen to hydrogen peroxide (possibly using alternative electron acceptors). Along with nuclear FHL2 it serves as a novel biomarker predictive for prostate cancer.

Rabbit IgG SR: chimpanzee, cow, dog, horse, human, mouse, orangutan, pig
Immunogen: a portion of amino acids 450-500 of human LSD1
Imgenex
Icon Datasheet
100 µg

Buy Bulk

302 €

IMG-6530A
related products

IHC ( paraffin ) , WB Erklärungen der Abkürzungen ansehen.
14-3-3 zeta is a 245 amino acid containing protein belonging to the 14-3-3 family mediating signal transduction by binding to phosphoserine containing proteins. It is a highly conserved protein in both plants and mammals. The encoded protein interacts with IRS1 implicating a plausible role in regulating insulin sensitivity. There are several transcript variants, with seven known mammalian isoforms: alpha, beta, gamma, delta, epsilon, zeta and eta. 14-3-3 proteins function in broad regulation of proteins by cytoplasmic sequestration, occupation of interaction domains and import/export sequences, prevention of degradation, and activation/repression of enzyme activity. The protein is highly abundant in brain.

Rabbit IgG SR: chimpanzee, cow, dog, human, mouse, opossum, pig
Immunogen: portion of amino acids 50-100 of human 14-3-3 zeta
Imgenex
Icon Datasheet
100 µg

Buy Bulk

302 €

IMG-6531A
related products

WB Erklärungen der Abkürzungen ansehen.
14-3-3 zeta is a 245 amino acid containing protein belonging to the 14-3-3 family mediating signal transduction by binding to phosphoserine containing proteins. It is a highly conserved protein in both plants and mammals. The encoded protein interacts with IRS1 implicating a plausible role in regulating insulin sensitivity. There are several transcript variants, with seven known mammalian isoforms: alpha, beta, gamma, delta, epsilon, zeta and eta. 14-3-3 proteins function in broad regulation of proteins by cytoplasmic sequestration, occupation of interaction domains and import/export sequences, prevention of degradation, and activation/repression of enzyme activity. The protein is highly abundant in brain.

Rabbit IgG SR: chimpanzee, cow, dog, human, mouse, rat, rhesus monkey
Immunogen: portion of amino acids 200-245 of human 14-3-3 zeta
Imgenex
Icon Datasheet
100 µg

Buy Bulk

302 €

IMG-571
related products

WB Erklärungen der Abkürzungen ansehen.
Rabbit IgG SR: human, mouse
Immunogen: synthetic peptides corresponding to amino acids 4-16 and 60-75 of human SUMO 2/3
Imgenex
Icon Datasheet
100 µg

Buy Bulk

302 €

IMG-266A
related products

IF / ICC, WB Erklärungen der Abkürzungen ansehen.
Mouse IgG1 kappa SR: human, mouse
Immunogen: His-tag recombinant mouse Dnmt3a
Imgenex
Icon Datasheet
100 µg

Buy Bulk

337 €

IMG-266B
related products

WB, IF / ICC Erklärungen der Abkürzungen ansehen.
Mouse IgG1 SR: human, mouse
Immunogen: His-tag recombinant mouse Dnmt3a
Imgenex
Icon Datasheet
100 µg

Buy Bulk

348 €

IMG-268A
related products

ChIP, IF / ICC, IHC  ( paraffin ) , WB Erklärungen der Abkürzungen ansehen.
Mouse IgG1 kappa SR: human, mouse
Immunogen: His-tag recombinant mouse Dnmt3a
Imgenex
Icon Datasheet
100 µg

Buy Bulk

337 €

IMG-6465A
related products

WB Erklärungen der Abkürzungen ansehen.
Dnmt3a, also known as DNA (cytosine-5)-methyltransferase 3A, is a nuclear protein belonging to the C5-methyltransferase family with an ADD-type zinc finger and a PWWP domain. Dnmt3a localizes to euchromatin and is essential for genome wide de novo methylation and is also essential for development.

Rabbit Ig SR: chimpanzee, human, rhesus monkey
Immunogen: synthetic peptide (portion of amino acids 10-50 of human Dnmt3a)
Imgenex
Icon Datasheet
100 µg

Buy Bulk

302 €

IMG-6466A
related products

WB Erklärungen der Abkürzungen ansehen.
Dnmt3a, also known as DNA (cytosine-5)-methyltransferase 3A, is a nuclear protein belonging to the C5-methyltransferase family with an ADD-type zinc finger and a PWWP domain. Dnmt3a localizes to euchromatin and is essential for genome wide de novo methylation and is also essential for development.

Rabbit Ig SR: cat, chicken, chimpanzee, bovine, horse, human, mouse
Immunogen: synthetic peptide (portion of amino acids 170-220 of human Dnmt3a)
Imgenex
Icon Datasheet
100 µg

Buy Bulk

302 €

IMG-6831A
WB Erklärungen der Abkürzungen ansehen.
Methylation of DNA at cytosine residues plays an important role in regulation of gene expression, genomic imprinting and is essential for mammalian development. Hypermethylation of CpG islands in tumor suppressor genes or hypomethylation of bulk genomic DNA may be linked with development of cancer. To date, 3 families of mammalian DNA methyltransferase genes have been identified which include Dnmt1, Dnmt2 and Dnmt3. Dnmt1 is constitutively expressed in proliferating cells and inactivation of this gene causes global demethylation of genomic DNA and embryonic lethality. Dnmt2 is expressed at low levels in adult tissues and its inactivation does not affect DNA methylation or maintenance of methylation. The Dnmt3 family members, Dnmt3a and Dnmt3b, are strongly expressed in ES cells but their expression is down regulated in differentiating ES cells and is low in adult somatic tissue. Recently, it has been shown that naturally occurring mutations of Dnmt3b gene occurs in patients with a rare autosomal recessive disorder, termed ICF (immunodeficiency, centromeric instability, and facial anomalies) syndrome.

Rabbit IgG SR: human
Immunogen: synthetic peptides corresponding to amino acids 150-165 ([BLAST]GKEQKETNIESMKMEG[/BLAST]) and 175-192 ([BLAST]GWESSLRQRPMPRLTFQA[/BLAST]) of Dnmt3a.
Imgenex
Icon Datasheet
100 µg

Buy Bulk

302 €

IMG-276
related products

WB Erklärungen der Abkürzungen ansehen.
Rabbit IgG SR: human
Immunogen: synthetic peptide corresponding to amino acids 3-14 that is common in human and mouse Bcl-XL and Bcl-XS protein
Imgenex
Icon Datasheet
100 µg

Buy Bulk

302 €

IMG-5690
related products

IHC  ( frozen ) , IHC  ( paraffin ) , IP, WB Erklärungen der Abkürzungen ansehen.
Rabbit SR: dog, gerbil, human, mouse, rat
Immunogen: recombinant human Bcl-XL protein without the N-terminal transmembrane portion
Imgenex
Icon Datasheet
50 µl

Buy Bulk

267 €

IMG-5691
related products

WB, IHC  ( paraffin ) , IHC  ( frozen ) , IP Erklärungen der Abkürzungen ansehen.
Rabbit SR: human, mouse, rat, gerbil
Immunogen: synthetic peptide
Imgenex
Icon Datasheet
50 µl

Buy Bulk

267 €

IMG-5692
related products

IHC  ( frozen ) , IHC  ( paraffin ) , IP, WB Erklärungen der Abkürzungen ansehen.
Rabbit SR: gerbil, human, mouse, rat
Immunogen: synthetic peptide
Imgenex
Icon Datasheet
50 µl

Buy Bulk

267 €

IMG-340
related products

ChIP, IP, WB Erklärungen der Abkürzungen ansehen.
Rabbit IgG SR: human, mouse
Immunogen: synthetic peptide corresponding to amino acids 1-16 of human HDAC6
Imgenex
Icon Datasheet
100 µg

Buy Bulk

337 €

IMG-2203
TLR3 activation Erklärungen der Abkürzungen ansehen.
Polyinosinic-polycytidylic acid (Poly(I:C)) is a synthetic analog of double stranded RNA (dsRNA) of viruses. Poly (I:C) is known to induce type-1 interferon (IFN) through TLR3. Poly(I:C) directly binds to TLR3.
Imgenex
Icon Datasheet
1 mg

Buy Bulk

220 €

IMG-315A
related products

FC  ( Cell Surface ) , FC  ( Intracellular ) , IF / ICC, IHC  ( paraffin ) , IP, WB Erklärungen der Abkürzungen ansehen.
Mouse IgG1 kappa SR: dog, human
Immunogen: synthetic peptide
Imgenex
Icon Datasheet
100 µg

Buy Bulk

337 €

IMG-315AF488
FC ( CS,IC ) , IF / ICC Erklärungen der Abkürzungen ansehen.
The TLR family is a phylogenetically conserved mediator of innate immunity that is essential for microbial recognition. TLR3 has a restricted expression pattern being expressed in dendritic cells (DC).

Mouse IgG1 kappa SR: dog, human
Immunogen: synthetic peptide
Imgenex
Icon Datasheet
100 µg

Buy Bulk

395 €

IMG-315AF647
FC ( CS ) , FC ( IC ) , IF / ICC Erklärungen der Abkürzungen ansehen.
The Toll-like receptor (TLR) family in mammal comprises a family of transmembrane proteins characterized by multiple copies of leucine rich repeats in the extracellular domain and IL-1 receptor motif in the cytoplasmic domain. Like its counterparts in Drosophila, TLRs signal through adaptor molecules and could constitute an important and unrecognized component of innate immunity in humans. The TLR family is a phylogenetically conserved mediator of innate immunity that is essential for microbial recognition. TLRs characterized so far activate the MyD88/interleukin-1 receptor-associated kinase (IRAK) signaling pathway. Ten human homologs of TLRs (TLR1-10) have been described. TLR3 cDNA codes for a protein with approximate molecular weight of 120 kDa. TLR3 has a restricted expression pattern being expressed in dendritic cells (DC) (4-6). TLR3 mRNA expression was detected by in situ hybridization in DC and lymph nodes. The expression of TLR3 in a single cell type may indicate a specific role for this molecule in a restricted set

Mouse IgG1 kappa SR: dog, human, mouse
Immunogen: KLH-conjugated synthetic peptide of human TLR3
Imgenex
Icon Datasheet
100 µg

Buy Bulk

395 €

IMG-315B
related products

ELISA, FC  ( Cell Surface ) , FC  ( Intracellular ) , IHC  ( paraffin )  Erklärungen der Abkürzungen ansehen.
Mouse IgG1 kappa SR: human
Immunogen: synthetic peptide
Imgenex
Icon Datasheet
100 µg

Buy Bulk

348 €

IMG-315C
related products

FC  ( Cell Surface ) , FC  ( Intracellular ) , IF / ICC Erklärungen der Abkürzungen ansehen.
Mouse IgG1 kappa SR: human
Immunogen: synthetic peptide
Imgenex
Icon Datasheet
100 µg

Buy Bulk

348 €

IMG-315D
related products

FC  ( Cell Surface ) , FC  ( Intracellular )  Erklärungen der Abkürzungen ansehen.
Mouse IgG1 kappa SR: human
Immunogen: synthetic peptide
Imgenex
Icon Datasheet
100 µg

Buy Bulk

348 €

IMG-5348A
related products

WB Erklärungen der Abkürzungen ansehen.
TLR3 has a restricted expression pattern being expressed in dendritic cells (DC).

Rabbit IgG SR: human
Immunogen: synthetic peptide corresponding to amino acids 755-767 of human TLR3 (pTyr759)
Imgenex
Icon Datasheet
20 µg

Buy Bulk

348 €

IMG-6315A
related products

IHC, WB Erklärungen der Abkürzungen ansehen.
This polyclonal antibody may block dsRNA binding to TLR3.

Rabbit IgG SR: chimpanzee, cow, gorilla, human, macaque, mouse, opossum, rat
Immunogen: synthetic peptide containing H-539 and N-541, two important amino acids involved in the binding of dsRNA to TLR3
Imgenex
Icon Datasheet
100 µg

Buy Bulk

302 €

IMG-6444A
related products

IHC ( paraffin ) , WB Erklärungen der Abkürzungen ansehen.
TLR3 has a restricted expression pattern being expressed in dendritic cells (DC). TLR3 mRNA expression was detected by in situ hybridization in DC and lymph nodes. The expression of TLR3 in a single cell type may indicate a specific role for this molecule in a restricted setting.

Rabbit IgG SR: chimpanzee, gorilla, human, macaque, rhesus monkey
Immunogen: synthetic peptide
Imgenex
Icon Datasheet
100 µg

Buy Bulk

302 €

IMG-6755AF488
FC  ( IC )  Erklärungen der Abkürzungen ansehen.
TLR3, also classified as CD283, appears to be one of the major sensors of RNA viruses. Viral recognition by endosomal TLRs induces Type I Interferon production and release. TLR3 is the only human TLR which does not utilize MyD88 as an adaptor molecule instead utilizing TRIF in a signaling path which results in downstream activation of IRF-3 and NF-kappaB. IRF-3 is a major inducer itself of Type I interferons like IFNb through activation via viral derived dsRNAs or poly I:C. TLR3 activation leads not only to Type I interferon induction but also to other inflammatory cytokines which result in DC maturation. Through its recognition of dsRNA, TLR3 also appears to potentiate immune responses and TLR3 agonists have been exploited as vaccine adjuvants.

Rabbit IgG SR: human, mouse
Immunogen: portion of amino acids 325-375 of mouse TLR3.
Imgenex
Icon Datasheet
100 µg

Buy Bulk

348 €

IMG-6755AF647
FC  ( IC )  Erklärungen der Abkürzungen ansehen.
TLR3, also classified as CD283, appears to be one of the major sensors of RNA viruses. Viral recognition by endosomal TLRs induces Type I Interferon production and release. TLR3 is the only human TLR which does not utilize MyD88 as an adaptor molecule instead utilizing TRIF in a signaling path which results in downstream activation of IRF-3 and NF-kappaB. IRF-3 is a major inducer itself of Type I interferons like IFNb through activation via viral derived dsRNAs or poly I:C. TLR3 activation leads not only to Type I interferon induction but also to other inflammatory cytokines which result in DC maturation. Through its recognition of dsRNA, TLR3 also appears to potentiate immune responses and TLR3 agonists have been exploited as vaccine adjuvants.

Rabbit IgG SR: human, mouse
Immunogen: portion of amino acids 325-375 of mouse TLR3.
Imgenex
Icon Datasheet
100 µg

Buy Bulk

348 €

IML-103
Agonist screening, functional assays Erklärungen der Abkürzungen ansehen.
Stably co-transfected cell line which expresses human Toll-like receptor 3 (TLR3) and the secreted alkaline phosphatase (SEAP) reporter gene under the transcriptional control of an NF-kappaB response element.
Imgenex
Icon Datasheet
1 each

Buy Bulk

1223 €

IML-203
FC calibration, control Erklärungen der Abkürzungen ansehen.
TLR3/HEK 293 is a stably transfected cell line which expresses full-length human Toll-like receptor 3 (TLR3) with an N-terminal HA tag.
Imgenex
Icon Datasheet
1 each

Buy Bulk

947 €

IMG-256A
related products

WB Erklärungen der Abkürzungen ansehen.
Protein function: Cytokine that binds to TNFRSF10A/TRAILR1, TNFRSF10B/TRAILR2, TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4 and possibly also to TNFRSF11B/OPG. Induces apoptosis. Its activity may be modulated by binding to the decoy receptors TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4 and TNFRSF11B/OPG that cannot induce apoptosis. [The UniProt Consortium]

Mouse IgG SR: human
Immunogen: synthetic peptide corresponding to amino acids 17-35 of human TRAIL This peptide sequence has been shown to be involved in TRAIL and DR5 (TRAIL-R2) interaction
Imgenex
Icon Datasheet
100 µg

Buy Bulk

337 €

IMG-6099A
related products

WB Erklärungen der Abkürzungen ansehen.
RDC1/CXCR7 is a 362 amino acid CXC chemokine receptor involved in a number of pathobiologic processes, including cell growth, survival and adhesion, and tumor growth.

Rabbit IgG SR: chimpanzee, cow, horse, human, monkey, mouse, rat
Immunogen: synthetic peptide
Imgenex
Icon Datasheet
100 µg

Buy Bulk

302 €

IMG-505
related products

WB Erklärungen der Abkürzungen ansehen.
Rabbit IgG SR: human
Immunogen: mixture of synthetic peptides corresponding to human PRMT5 amino acid sequence PRMT = Protein aRginine MethylTransferase JBP = Janus kinase-binding protein
Imgenex
Icon Datasheet
200 µl

Buy Bulk

302 €

IMG-5733
related products

WB, IHC  ( paraffin ) , IHC  ( frozen ) , IP Erklärungen der Abkürzungen ansehen.
Rabbit SR: human
Immunogen: synthetic peptide
Imgenex
Icon Datasheet
50 µl

Buy Bulk

267 €

IMG-5985A
related products

WB Erklärungen der Abkürzungen ansehen.
Runt-related transcription factor 2 is involved in osteoblastic differentiation and skeletal morphogenesis. Essential for the maturation of osteoblasts and both intramembranous and endochondral ossification. CBF binds to the core site, 5'-PYGPYGGT-3', of a number of enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers, osteocalcin, osteopontin, bone sialoprotein, alpha 1(I) collagen, LCK, IL-3 and GM-CSF promoters. In osteoblasts, supports transcription activation: synergizes with SPEN/MINT to enhance FGFR2-mediated activation of the osteocalcin FGF-responsive element (OCFRE). It inhibits KAT6B-dependent transcriptional activation. It is specifically expressed in osteoblasts.[The UniProt Consortium]

Rabbit IgG SR: chicken, chimpanzee, horse, human, monkey, mouse
Immunogen: synthetic peptide
Imgenex
Icon Datasheet
100 µg

Buy Bulk

302 €

IMG-441
related products

IP, WB Erklärungen der Abkürzungen ansehen.
Rabbit IgG SR: human, mouse
Immunogen: mixture of synthetic peptides containing amino acids 38-54 and 120-136 of mouse IRAK-4
Imgenex
Icon Datasheet
200 µl

Buy Bulk

302 €

IMG-5705
related products

IHC  ( frozen ) , IHC  ( paraffin ) , IP, WB Erklärungen der Abkürzungen ansehen.
Rabbit SR: dog, gerbil, human, mouse, rat
Immunogen: recombinant catalytically active human Caspase-9 protein
Imgenex
Icon Datasheet
50 µl

Buy Bulk

302 €

IMG-5706
related products

IHC  ( frozen ) , IHC  ( paraffin ) , IP, WB Erklärungen der Abkürzungen ansehen.
Rabbit SR: dog, gerbil, human, mouse, rat
Immunogen: recombinant full-length human Caspase-9 protein (pro-form)
Imgenex
Icon Datasheet
50 µl

Buy Bulk

302 €

IMG-5707
related products

IHC  ( frozen ) , IHC  ( paraffin ) , IP, WB Erklärungen der Abkürzungen ansehen.
Rabbit SR: human
Immunogen: synthetic peptide
Imgenex
Icon Datasheet
50 µl

Buy Bulk

267 €

IMG-5708
related products

IHC  ( frozen ) , IHC  ( paraffin ) , IP, WB Erklärungen der Abkürzungen ansehen.
Rabbit SR: human
Immunogen: synthetic peptide
Imgenex
Icon Datasheet
50 µl

Buy Bulk

267 €

IMG-5709
related products

IHC  ( frozen ) , IHC  ( paraffin ) , IP, WB Erklärungen der Abkürzungen ansehen.
Rabbit SR: human
Immunogen: synthetic phosphopeptide corresponding to amino acids 188-206
Imgenex
Icon Datasheet
50 µl

Buy Bulk

267 €

IMG-6265A
related products

WB Erklärungen der Abkürzungen ansehen.
AXL may function as a signal transducer between specific cell types of mesodermal origin and may transduce signals from the extracellular matrix into the cytoplasm

Rabbit Ig SR: human, mouse, rat
Immunogen: synthetic peptide
Imgenex
Icon Datasheet
100 µg

Buy Bulk

337 €

IMG-6262A
related products

WB Erklärungen der Abkürzungen ansehen.
Laforin plays an important role in the regulation of glycogen metabolism, prevents the formation of polyglucasans, and hydrolyze phosphotyrosine and phosphoserine/threonine substrates.

Rabbit Ig SR: cow, human
Immunogen: synthetic peptide
Imgenex
Icon Datasheet
100 µg

Buy Bulk

302 €

IMG-6391A
related products

WB Erklärungen der Abkürzungen ansehen.
USP7 (ubiquitin specific peptidase 7) is a nuclear protein belonging to the peptidase C19 family with a MATH domain and is known to cleave ubiquitin fusion protein substrates.

Rabbit IgG SR: chicken, chimpanzee, dog, horse, human, macaque, mouse, rat
Immunogen: synthetic peptide
Imgenex
Icon Datasheet
100 µg

Buy Bulk

302 €

IMG-6392A
related products

IHC ( paraffin ) , WB Erklärungen der Abkürzungen ansehen.
USP7 (ubiquitin specific peptidase 7) is a nuclear protein belonging to the peptidase C19 family with a MATH domain and is known to cleave ubiquitin fusion protein substrates.

Rabbit IgG SR: chicken, chimpanzee, dog, horse, human, macaque, mouse, rat
Immunogen: synthetic peptide
Imgenex
Icon Datasheet
100 µg

Buy Bulk

302 €

IMG-5950A
related products

WB Erklärungen der Abkürzungen ansehen.
FOXO1A is a 655 amino acid protein belonging to the forkhead family of transcription activators which is characterized by a distinct forkhead domain. The specific function of this protein has not yet been determined, however, it may play a role in myogenic growth and differentiation. It is also known to have a tumor suppressor function by inhibiting cell proliferation and survival. When fused to PAX3 it is known to cause alveolar rhabdomyosarcoma.

Rabbit Ig SR: chimpanzee, cow, dog, human, monkey, mouse, rat
Immunogen: a portion of amino acids 250-300 of human FOXO1a protein
Imgenex
Icon Datasheet
100 µg

Buy Bulk

302 €

IMG-6384A
related products

WB Erklärungen der Abkürzungen ansehen.
FOXO1A is a protein belonging to the forkhead family of transcription activators which is characterized by a distinct forkhead domain.

Rabbit Ig SR: chimpanzee, bovine, dog, human, monkey, mouse, rat
Immunogen: synthetic peptide
Imgenex
Icon Datasheet
20 µg

Buy Bulk

220 €

IMG-5714
related products

IHC  ( frozen ) , IHC  ( paraffin ) , IP, WB Erklärungen der Abkürzungen ansehen.
Rabbit IgG SR: dog, gerbil, human, mouse, rat
Immunogen: recombinant protein containing the short cytoplasmic domain of the human CD40 molecule
Imgenex
Icon Datasheet
50 µl

Buy Bulk

150 €

IMG-6087A
related products

WB Erklärungen der Abkürzungen ansehen.
Rabbit IgG SR: bovine, human, mouse
Immunogen: synthetic peptide
Imgenex
Icon Datasheet
100 µg

Buy Bulk

302 €

IMG-6088A
related products

WB Erklärungen der Abkürzungen ansehen.
Rabbit IgG SR: human, mouse, rat
Immunogen: synthetic peptide
Imgenex
Icon Datasheet
100 µg

Buy Bulk

302 €

IMG-5323A
related products

WB Erklärungen der Abkürzungen ansehen.
Rabbit IgG SR: human
Immunogen: synthetic peptide corresponding to amino acids 6-20 of human Rictor
Imgenex
Icon Datasheet
100 µg

Buy Bulk

302 €

IMG-348
related products

WB Erklärungen der Abkürzungen ansehen.
Mouse IgG1 SR: human
Immunogen: synthetic peptide of human p63
Imgenex
Icon Datasheet
100 µg

Buy Bulk

302 €

IMG-5798A
related products

WB Erklärungen der Abkürzungen ansehen.
Rabbit IgG SR: chimpanzee, goat, human, mouse, rhesus monkey
Immunogen: synthetic peptide
Imgenex
Icon Datasheet
100 µg

Buy Bulk

302 €

IMG-6746A
WB, IHC Erklärungen der Abkürzungen ansehen.
This antibody will detect both isoforms of 14-3-3 sigma (248 amino acids and 169 amino acids). Protein function: Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. When bound to KRT17, regulates protein synthesis and epithelial cell growth by stimulating Akt/mTOR pathway. p53-regulated inhibitor of G2/M progression. [The UniProt Consortium]
Imgenex
Icon Datasheet
100 µg

Buy Bulk

302 €

10049P
JM2, IPEX, FOXP3, Scurfin, Forkhead box protein P3
Imgenex
Icon Datasheet
1 µg

Buy Bulk

500 €

IMG-6018A
related products

WB, FC  ( intracellular )  Erklärungen der Abkürzungen ansehen.
FOXP3 is a master regulator of immune homeostasis expressed specifically in CD4+ C25+ T regulatory cells. Clone 10D4G6 specifically detects the splice variant form FOXP3delta2 in contrast to other commercially available antibodies.

Mouse IgM kappa SR: human
Immunogen: synthetic peptide corresponding to the exon 2 deletion site
Imgenex
Icon Datasheet
100 µg

Buy Bulk

337 €

IMG-6018E
related products

WB Erklärungen der Abkürzungen ansehen.
FoxP3, a transcription factor, is a specific molecular marker essential for the development and function of regulatory T-cells (Tregs ).

Mouse IgM kappa SR: human
Immunogen: synthetic peptide
Imgenex
Icon Datasheet
100 µg

Buy Bulk

348 €

IMG-6065A
related products

WB Erklärungen der Abkürzungen ansehen.
Rabbit IgG SR: bovine, chicken, horse, human, pig, rat, rhesus monkey
Immunogen: synthetic peptide
Imgenex
Icon Datasheet
100 µg

Buy Bulk

267 €

IMG-6428A
related products

WB Erklärungen der Abkürzungen ansehen.
Beta-arrestin 1 is a 418 amino acid containing signaling neurotransmitter that belongs to the arrestin family with an arrestin N terminal and an arrestin C terminal domain.

Rabbit IgG SR: bovine, human, mouse, rat, zebrafish
Immunogen: synthetic peptide
Imgenex
Icon Datasheet
100 µg

Buy Bulk

302 €

IMG-6074A
related products

WB Erklärungen der Abkürzungen ansehen.
Rabbit IgG SR: chimpanzee, horse, human, monkey, mouse
Immunogen: synthetic peptide
Imgenex
Icon Datasheet
100 µg

Buy Bulk

302 €

IMG-5917A
FC  ( Cell Surface )  Erklärungen der Abkürzungen ansehen.
Mouse IgG1 kappa SR: human
Imgenex
Icon Datasheet
100 µg

Buy Bulk

150 €

IMG-5917C
FC  ( Cell Surface )  Erklärungen der Abkürzungen ansehen.
Mouse IgG1 kappa SR: human
Imgenex
Icon Datasheet
100 tests

Buy Bulk

220 €

IMG-5917D
FC  ( Cell Surface )  Erklärungen der Abkürzungen ansehen.
Mouse IgG1 kappa SR: human
Imgenex
Icon Datasheet
100 tests

Buy Bulk

220 €

IMG-5917G
FC  ( Cell Surface )  Erklärungen der Abkürzungen ansehen.
CD8 acts as a coreceptor during T cell activation through the binding of MHC Class I molecules and is found on T lymphocytes that mediates efficient cell-cell interactions within the immune system.

Mouse IgG1 kappa SR: human
Imgenex
Icon Datasheet
100 Tests

Buy Bulk

220 €

IMG-319
related products

FC  ( Cell Surface ) , FC  ( Intracellular ) , WB Erklärungen der Abkürzungen ansehen.
Mouse IgG1 SR: human
Immunogen: extracellular domain of human TLR2
Imgenex
Icon Datasheet
100 µg

Buy Bulk

302 €

IMG-410A
related products

WB, IHC Erklärungen der Abkürzungen ansehen.
MW: 90 kD
Rabbit IgG SR: human
Immunogen: synthetic peptides corresponding to amino acids 180-196, 353-370, and 473-489 of human TLR2
Imgenex
Icon Datasheet
100 µg

Buy Bulk

302 €

IMG-410E
related products

WB Erklärungen der Abkürzungen ansehen.
MW: 90 kD
Rabbit IgG SR: human, mouse
Immunogen: synthetic peptides corresponding to amino acids 180-196, 353-370 and 473-489 of human TLR2
Imgenex
Icon Datasheet
100 µg

Buy Bulk

337 €

IMG-416A
related products

FC  ( Cell Surface ) , FC  ( Intracellular ) , IF / ICC, IP Erklärungen der Abkürzungen ansehen.
Mouse IgG2a SR: dog, human
Immunogen: CHO cells transfected with human TLR2 cDNA
Imgenex
Icon Datasheet
100 µg

Buy Bulk

302 €

IMG-416AF488
FC ( CS,IC ) , IF / ICC Erklärungen der Abkürzungen ansehen.
The expression of TLR2 in different cell types is regulated by different immune response modifiers. LPS, GM-CSF, IL-1, and IL-10 up regulates TLR2 whereas IL-4, IFN-gamma, and TNF down regulate TLR2 expression in monocytes.

Mouse IgG2a kappa SR: dog, human
Immunogen: human TLR2 cDNA
Imgenex
Icon Datasheet
100 µg

Buy Bulk

348 €

IMG-416AF647
FC ( CS ) , FC ( IC ) , IF / ICC Erklärungen der Abkürzungen ansehen.
The Toll-like receptors (TLRs) in mammals comprise a family of transmembrane proteins characterized by multiple copies of leucine rich repeats in the extracellular domain and an IL-1 receptor motif in the cytoplasmic domain. Like its counterparts in Drosophila, TLRs signal through adaptor molecules. The TLR family is a phylogenetically conserved mediator of innate immunity that is essential for microbial recognition. Ten human homologs of TLRs (TLR1-10) have been described. TLR2 is differentially expressed in human cells. TLR2 is expressed in tonsils, lymph nodes, and appendices, activated B-cells in germinal centers. CD14 monocytes expressed the highest level of TLR2 followed by CD15 granulocytes, and CD19 B-cells, CD3 T-cells, and CD56 NK cells did not express TLR2. The expression of TLR2 in different cell types is regulated by different immune response modifiers. For example, LPS, GM-CSF, IL-1, and IL-10 up regulates TLR2 whereas IL-4, IFN-gamma, and TNF down regulate TLR2 expression in monocytes.

Mouse IgG2a kappa SR: dog, human
Immunogen: CHO cells transfected with human TLR2 cDNa
Imgenex
Icon Datasheet
100 µg

Buy Bulk

348 €

IMG-416B
FC  ( Intracellular ) , FC  ( Cell Surface ) , IF / ICC, IP Erklärungen der Abkürzungen ansehen.
Mouse IgG2a kappa SR: human
Immunogen: CHO cells transfected with human TLR2 cDNA
Imgenex
Icon Datasheet
100 µg

Buy Bulk

348 €

IMG-416C
related products

FC  ( Cell Surface ) , FC  ( Intracellular ) , IF / ICC Erklärungen der Abkürzungen ansehen.
Mouse IgG2a SR: dog, human
Immunogen: CHO cells transfected with human TLR2 cDNA
Imgenex
Icon Datasheet
100 µg

Buy Bulk

348 €

IMG-416D
related products

FC Erklärungen der Abkürzungen ansehen.
Mouse IgG2a kappa SR: dog, human
Immunogen: CHO cells transfected with human TLR2 cDNA
Imgenex
Icon Datasheet
100 µg

Buy Bulk

395 €

IMG-416E
related products

FA  ( Neutr. ) , FC  ( Cell Surface ) , FC  ( Intracellular ) , IF / ICC, IP Erklärungen der Abkürzungen ansehen.
Mouse IgG2a SR: dog, human
Immunogen: CHO cells transfected with human TLR2 cDNA
Imgenex
Icon Datasheet
100 µg

Buy Bulk

337 €

IML-102
Agonist screening, functional assays Erklärungen der Abkürzungen ansehen.
Stably co-transfected cell line which expresses human Toll-like receptor 2 (TLR2) and the secreted alkaline phosphatase (SEAP) reporter gene under the transcriptional control of an NF-kappaB response element.
Imgenex
Icon Datasheet
1 each

Buy Bulk

1223 €

IML-202
FC calibration, control Erklärungen der Abkürzungen ansehen.
TLR2/HEK 293 is a stably transfected cell line which expresses full-length human Toll-like receptor 2 (TLR2) with an N-terminal HA tag.
Imgenex
Icon Datasheet
1 each

Buy Bulk

947 €

IMG-6030A
related products

WB, ELISA Erklärungen der Abkürzungen ansehen.
OCT4 is a mammalian POU transcription factor expressed by early embryo cells and germ cells. The human OCT4 gene maps to chromosome 6 and has two isoforms with identical C-termini that include the characteristic POU-specific domain and the POU home domain. OCT4 is initially expressed in unfertilized oocytes and then in totipotent and pluripotent cells of the inner cell mass of pre-gastrulation embryos before becoming specific to germ-line cells. The OCT4 gene is expressed at low levels in such diverse adult tissues as heart, kidney, liver, spleen, and pancreatic islets. Specific functions of OCT4 have not been established. The expression of OCT4 in unfertilized oocytes and blastocysts is probably of greatest significance because of the role that OCT4 may be playing in early post fertilization events.

Rabbit IgG SR: chimpanzee, cow, dog, human, mouse, rat
Immunogen: amino acids 230-244 of human OCT4 protein
Imgenex
Icon Datasheet
100 µg

Buy Bulk

302 €

IMG-6098A
related products

WB Erklärungen der Abkürzungen ansehen.
FOXO3A promotes DNA repair under low stress conditions and a program of cell death under higher level of stress thus protecting quiescent cells from oxidative stress.

Rabbit IgG SR: chicken, cow, dog, human, monkey, mouse, rat
Immunogen: synthetic peptide
Imgenex
Icon Datasheet
100 µg

Buy Bulk

302 €

IMG-6041A
related products

WB Erklärungen der Abkürzungen ansehen.
Rabbit Ig SR: human
Immunogen: synthetic peptide
Imgenex
Icon Datasheet
100 µl

Buy Bulk

302 €

IMG-6187A
related products

WB Erklärungen der Abkürzungen ansehen.
Expression of NDRG1 is markedly upregulated in various cells under such conditions as cell differentiation, hypoxia and exposure to heavy metals. However, its expression is repressed after cellular transformation.

Goat Ig SR: human
Immunogen: synthetic peptide
Imgenex
Icon Datasheet
100 µg

Buy Bulk

302 €

IMG-308
related products

ChIP, IP, WB Erklärungen der Abkürzungen ansehen.
Rabbit IgG SR: human
Immunogen: synthetic peptide corresponding to amino acids 2-17 of human HDAC3
Imgenex
Icon Datasheet
100 µg

Buy Bulk

337 €

IMG-6362A
related products

IHC ( paraffin ) , WB Erklärungen der Abkürzungen ansehen.
BMI1 is a 326 amino acid containing protooncogene belonging to the polycomb gene family with a RING-type zinc finger domain. A transcription factor and a senescence regulator, BMI1 is a component of the Polycomb group (PcG) multiprotein PRC1 complex, required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. An important role of BMI1 has been reported in regulating proliferation of stem cells and tumor cells in diverse adult epithelial tissues involved in human colorectal carcinogenesis by repressing the INK4a/ARF proteins (CDKN2A). This protein also plays an essential role in the generation of self-renewing adult hematopoietic stem cells and in the maintenance and expansion of immature granule cell precursors. BMI1 cooperates with the MYC oncogene to produce B-lymphomas. Ubiquitous expression is seen in most of the tissues.

Rabbit IgG SR: chimpanzee, human, macaque, mouse, rat
Immunogen: a portion of amino acids 270-320 of human BMI1
Imgenex
Icon Datasheet
100 µg

Buy Bulk

302 €

IMG-6083A
related products

WB Erklärungen der Abkürzungen ansehen.
Rabbit IgG SR: human, monkey, mouse
Immunogen: synthetic peptide
Imgenex
Icon Datasheet
100 µg

Buy Bulk

302 €

IMG-6271A
related products

WB Erklärungen der Abkürzungen ansehen.
EIF4B binds to both mRNA and 18S ribosomal RNA and thus acts as a bridge between the mRNA and the 40S ribosomal subunit during translation initiation.

Rabbit Ig SR: bovine, chicken, human, mouse, orangutan, rat
Immunogen: synthetic peptide corresponding to a portion of amino acids 150-200 of human eIF4B
Imgenex
Icon Datasheet
100 µg

Buy Bulk

302 €

IMG-6309A
related products

WB Erklärungen der Abkürzungen ansehen.
eIF4B binds to both mRNA and 18S ribosomal RNA and thus acts as a bridge between the mRNA and the 40S ribosomal subunit during translation initiation.

Rabbit Ig SR: chimpanzee, human, mouse, orangutan, rhesus monkey
Immunogen: synthetic peptide
Imgenex
Icon Datasheet
100 µg

Buy Bulk

302 €

IMG-369
related products

WB Erklärungen der Abkürzungen ansehen.
Rabbit IgG SR: human
Immunogen: synthetic peptides corresponding to amino acids 66-81 and 135-151 of human INHAT-1
Imgenex
Icon Datasheet
200 µl

Buy Bulk

302 €

IMG-576
related products

WB Erklärungen der Abkürzungen ansehen.
Rabbit IgG SR: human
Immunogen: synthetic peptide corresponding to amino acids 2-18 of human MEK-2
Imgenex
Icon Datasheet
100 µg

Buy Bulk

302 €

IMG-5747
related products

IHC  ( frozen ) , IHC  ( paraffin ) , IP, WB Erklärungen der Abkürzungen ansehen.
Rabbit SR: human
Immunogen: synthetic peptide
Imgenex
Icon Datasheet
50 µl

Buy Bulk

267 €

IMG-6072A
related products

WB Erklärungen der Abkürzungen ansehen.
Rabbit IgG SR: human
Immunogen: synthetic peptide
Imgenex
Icon Datasheet
100 µg

Buy Bulk

302 €

IMG-6081A
related products

WB Erklärungen der Abkürzungen ansehen.
Rabbit IgG SR: bovine, human, monkey, mouse, rat
Immunogen: synthetic peptide
Imgenex
Icon Datasheet
100 µg

Buy Bulk

337 €

IMG-2209Hpt
TLR9  ( human )  activation Erklärungen der Abkürzungen ansehen.
Synthetic oligodeoxynucleotides (ODN) containing unmethylated deoxycytosine-deoxyguanosine (CpG) motifs are very potent inducers of the innate immune system. Negative control contains GpC instead of CpG.
Imgenex
Icon Datasheet
100 µg

Buy Bulk

302 €

IMG-2209Mpt
TLR9 activation Erklärungen der Abkürzungen ansehen.
Mouse specific TLR9 ligand (Type b) (16.4 nmole). Stimulation of mouse TLR9 has been reported with 0.5-5 mg/l. Negative control contains GpC instead of CpG.
Imgenex
Icon Datasheet
100 µg

Buy Bulk

337 €

IMG-305A
related products

FC  ( Cell Surface & Intracellular ) , IF / ICC, IHC  ( frozen & paraffin ) , WB Erklärungen der Abkürzungen ansehen.
For IHC on frozen and paraffin tissue. Please, see datasheet for list of application references.

Mouse IgG1 kappa SR: dog, horse, human, mouse, rat, rhesus monkey
Immunogen: synthetic peptide corresponding to amino acids 268-284 of human TRL9
Imgenex
Icon Datasheet
100 µg

Buy Bulk

337 €

IMG-305AF488
FC ( IC,CS ) , CM, IF / ICC Erklärungen der Abkürzungen ansehen.
The TLR family is a phylogenetically conserved mediator of innate immunity that is essential for microbial recognition. TLR9 acts as a receptor for unmethylated CpG dinucleotides in the bacterial DNA.

Mouse IgG1 kappa SR: dog, horse, human, mouse, rat, rhesus monkey
Immunogen: synthetic peptide corresponding to amino acids 268-284 of human TLR9 isoform A
Imgenex
Icon Datasheet
100 µg

Buy Bulk

395 €

IMG-305AF647
FC ( IC,CS ) , CM, IF / ICC Erklärungen der Abkürzungen ansehen.
The TLR family is a phylogenetically conserved mediator of innate immunity that is essential for microbial recognition. TLR9 acts as a receptor for unmethylated CpG dinucleotides in the bacterial DNA.

Mouse IgG1 kappa SR: dog, horse, human, mouse, rat, rhesus monkey
Immunogen: synthetic peptide corresponding to amino acids 268-284 of human TLR9 isoform A
Imgenex
Icon Datasheet
100 µg

Buy Bulk

395 €

IMG-305B
related products

ELISA, FC  ( Cell Surface ) , FC  ( Intracellular ) , IF / ICC, IHC  ( frozen ) , IHC  ( paraffin )  Erklärungen der Abkürzungen ansehen.
Mouse IgG1 kappa SR: dog, horse, human, mouse, rat, rhesus monkey
Immunogen: synthetic peptide corresponding to amino acids 268-284 of human TRL9
Imgenex
Icon Datasheet
100 µg

Buy Bulk

395 €

IMG-305C
related products

FC  ( Cell Surface ) , FC  ( Intracellular ) , IF / ICC, IHC  ( frozen ) , IHC  ( paraffin ) , WB Erklärungen der Abkürzungen ansehen.
Mouse IgG1 kappa SR: dog, horse, human, mouse, rat, rhesus monkey
Immunogen: synthetic peptide corresponding to amino acids 268-284 of human TRL9
Imgenex
Icon Datasheet
100 µg

Buy Bulk

395 €

IMG-305D
related products

IF, FC  ( CS / Intracellular ) , IHC  ( frozen / paraffin )  Erklärungen der Abkürzungen ansehen.
Mouse IgG1 kappa SR: human, mouse, rat, rhesus monkey
Immunogen: synthetic peptide corresponding to amino acids 268-284 of human TRL9
Imgenex
Icon Datasheet
100 µg

Buy Bulk

395 €

IMG-305E
related products

IF, FC  ( CS ) , FC  ( Intracellular ) , IHC  ( frozen ) , IHC  ( paraffin ) , WB Erklärungen der Abkürzungen ansehen.
Mouse IgG1 kappa SR: human, mouse, rat, rhesus monkey
Imgenex
Icon Datasheet
100 µg

Buy Bulk

348 €

IML-109
Agonist screening, functional assays Erklärungen der Abkürzungen ansehen.
Stably co-transfected cell line which expresses full-length human Toll-like receptor 9 (TLR9) and the secreted alkaline phosphatase (SEAP) reporter gene under the transcriptional control of an NF-kappaB response element.
Imgenex
Icon Datasheet
1 vial

Buy Bulk

1223 €

IML-209
FC calibration, Control Erklärungen der Abkürzungen ansehen.
TLR9/HEK 293 is a stably transfected cell line which expresses full-length human Toll-like receptor 9 (TLR9) with no epitope tag. TLR9 expression in this cell line has been validated by fl ow cytometry. Functional activity of this cell line has been validated using the NF-kappaB/SEAPorter(TM) Assay Kit (IMK-515).
Imgenex
Icon Datasheet
1 vial

Buy Bulk

947 €

IMG-338
related products

ChIP, IP, WB Erklärungen der Abkürzungen ansehen.
Rabbit IgG SR: human, mouse
Immunogen: synthetic peptide corresponding to amino acids 194-209 of human HDAC4
Imgenex
Icon Datasheet
100 µg

Buy Bulk

337 €

IMG-588
related products

IHC  ( paraffin ) , WB Erklärungen der Abkürzungen ansehen.
Mouse IgG1 SR: human
Immunogen: synthetic peptide corresponding to amino acids 481-497 of human TEM8
Imgenex
Icon Datasheet
100 µg

Buy Bulk

302 €

IMG-6167A
related products

WB Erklärungen der Abkürzungen ansehen.
Transglutaminase 2 is historically a member of the transglutaminase family that catalyzes a calcium-dependent acyl transfer reaction between peptide bound glutamine and a suitable primary amine.The protein is known to participate in all-trans-retinoi

Rabbit IgG SR: human
Immunogen: synthetic peptide
Imgenex
Icon Datasheet
100 µg

Buy Bulk

302 €

IMG-6125A
related products

WB Erklärungen der Abkürzungen ansehen.
Rabbit Ig SR: chimpanzee, cow, dog, human, monkey, mouse, rat
Immunogen: synthetic peptide
Imgenex
Icon Datasheet
50 µg

Buy Bulk

337 €

IMG-6126A
related products

WB Erklärungen der Abkürzungen ansehen.
Rabbit Ig SR: chimpanzee, cow, dog, horse, human, monkey, zebrafish
Immunogen: synthetic peptide
Imgenex
Icon Datasheet
50 µg

Buy Bulk

302 €

IMG-6386A
related products

WB Erklärungen der Abkürzungen ansehen.
Rad17 ('cell cycle checkpoint protein RAD17'), is a nuclear protein belonging to the Rad17/RAD24 family and necessary for sustained cell growth, maintenance of chromosomal stability, and ATR-dependent checkpoint activation upon DNA damage.

Rabbit Ig SR: chimpanzee, human, orangutan, rhesus monkey
Immunogen: synthetic peptide
Imgenex
Icon Datasheet
20 µg

Buy Bulk

302 €

IMG-6668A
related products

WB Erklärungen der Abkürzungen ansehen.
NACHT, LRR and PYD domains-containing protein 3 belongs to the NLRP family and it contains one DAPIN domain, seven LRR (leucine-rich) repeats and one NATCH domain. It interacts with the apoptosis-associated speck-like protein PYCARD/ASC, which contains a caspase recruitment domain and is a member of the NALP3 inflammasome complex. This complex functions as an upstream activator of NF-kappaB signaling and it plays a role in the regulation of inflammation, the immune response and apoptosis. It is also reported that the NLRP3 inflammasome can be activated by pathogen-associated molecular patterns (PAMPs) or endogenous danger-associated molecular patterns (DAMPs). The activation of the NLRP3 inflammasome results in proteolytic activation and secretion of cytokines of the interleukin-1 (IL-1) family. Mutations in this gene are associated with familial cold autoinflammatory syndrome (FCAS), Muckle-Wells syndrome (MWS), chronic infantile neurological cutaneous and articular (CINCA) syndrome and neonatal-onset multi-system inflammatory disease (NOMID).

Rabbit IgG SR: human, monkey, mouse, rat
Immunogen: a portion of amino acids 1-50 of human NALP3
Imgenex
Icon Datasheet
100 µg

Buy Bulk

302 €

IMG-546
related products

WB Erklärungen der Abkürzungen ansehen.
Rabbit IgG SR: human, mouse, rat
Immunogen: synthetic peptides corresponding to amino acids 22-36 and 317-331 of human SMAD8
Imgenex
Icon Datasheet
200 µl

Buy Bulk

302 €

IMG-550
related products

WB Erklärungen der Abkürzungen ansehen.
Rabbit IgG SR: human, mouse, rat
Immunogen: synthetic peptides corresponding to amino acids 20-34 and 316-330 of human Smad5
Imgenex
Icon Datasheet
200 µl

Buy Bulk

302 €

IMG-566
related products

WB Erklärungen der Abkürzungen ansehen.
Rabbit IgG SR: human, mouse, rat
Immunogen: synthetic peptide corresponding to amino acids 23-36 & 317-332 of human Smad9
Imgenex
Icon Datasheet
200 µl

Buy Bulk

302 €

IMG-6841A
FC, WB Erklärungen der Abkürzungen ansehen.
Toll-like receptors (TLRs) are one of the mechanisms by which the innate immune system senses the invasion of pathogenic microorganisms. TLRs are primary transmembrane proteins of immune cells, they have an extracellular region which contains leucine-rich repeat motifs, and a cytoplasmic tail, which has a Toll/interleukin-1 (IL-1) receptor (TIR) domain. TLRs are pattern recognition receptors (PRRs ) that bind to pathogen-associated molecular patterns (PAMPs). Different TLRs recognize different surface and intracellular components of microorganisms or PAMPS. The interaction between a TLR and a microbial component or PAMP triggers the activation of the innate immune system, as well as the development of acquired immunity. Interaction of PAMPs with different TLRs induces distinct patters of gene expression through signal transduction pathways. TLR signaling occurs through the TIR domains which utilize adaptors such as MyD88, TIRAP, TRIF, and TRAM. NF-kapppa-B and JNK pathways are activated leading to the transcription of genes encoding pro-inflammatory cytokines. TLR-10, originally identified from a spleen cDNA library, is on chromosome 4p14 and has been found to be expressed in lung and in B-lymphocytes. TLR10 is thought to be a potential asthma candidate gene because early life innate immune responses to ubiquitous inhaled allergens and PAMPs may influence asthma susceptibility.

Mouse IgG2b kappa SR: human
Immunogen: Synthetic peptide
Imgenex
Icon Datasheet
100 µg

Buy Bulk

302 €

IMG-587
related products

WB Erklärungen der Abkürzungen ansehen.
This antibody, IMG-587, is specific for Set7/9 (a histone H3 lysine 4 methyltransferase) and does not recognize PR-Set7 (a histone H4 lysine 20 methyltransferase).

Rabbit IgG SR: mouse, human
Immunogen: synthetic peptide corresponding to amino acids 131-145 & 336-352 of human Set7
Imgenex
Icon Datasheet
200 µl

Buy Bulk

302 €

IMG-404A
related products

IHC  ( paraffin ) , WB Erklärungen der Abkürzungen ansehen.
Mouse IgG1 kappa SR: human
Immunogen: synthetic peptide corresponding to amino acids 335-350 of human Omi/HtrA2
Imgenex
Icon Datasheet
100 µg

Buy Bulk

302 €

IMG-404B
ELISA, IHC  ( paraffin )  Erklärungen der Abkürzungen ansehen.
Mouse IgG1 kappa SR: human
Immunogen: synthetic peptide containing amino acids 335-350 of human Omi/HtrA2
Imgenex
Icon Datasheet
100 µg

Buy Bulk

302 €

IMG-6562A
related products

IHC ( paraffin ) , WB Erklärungen der Abkürzungen ansehen.
hnRNPK is most extensively studied among heterogeneous nuclear ribonucleoproteins family, which plays an important role in cell signaling, telomere elongation, DNA repair and regulation of expression at both transcriptional and translational levels. It is a highly conserved RNA/DNA-binding protein which interacts with different classes of factors of extracellular signals.

Rabbit IgG SR: chimpanzee, human, monkey, mouse, opossum, rat
Immunogen: portion of amino acid 1 to 50 of human hnRNPK
Imgenex
Icon Datasheet
100 µg

Buy Bulk

302 €

IMG-6563A
related products

WB Erklärungen der Abkürzungen ansehen.
hnRNPK is most extensively studied among heterogeneous nuclear ribonucleoprotein families which plays an important role in cell signaling, telomere elongation, DNA repair and regulation of expression at both transcriptional and translational levels. It is a highly conserved RNA/DNA-binding protein which interacts with different classes of factors of extracellular signals.

Rabbit IgG SR: chimpanzee, human, monkey, mouse, opossum, rat
Immunogen: portion of amino acid 200 to 250 of human hnRNPK
Imgenex
Icon Datasheet
100 µg

Buy Bulk

302 €

IMG-6564A
IHC Erklärungen der Abkürzungen ansehen.
hnRNPK is most extensively studied among heterogeneous nuclear ribonucleoprotein families which plays an important role in cell signaling, telomere elongation, DNA repair and regulation of expression at both transcriptional and translational levels. It is a highly conserved RNA/DNA-binding protein which interacts with different classes of factors of extracellular signals.

Rabbit IgG SR: chimpanzee, human, monkey, mouse, opossum, rat
Immunogen: portion of amino acid 380 to 430 of human hnRNPK
Imgenex
Icon Datasheet
100 µg

Buy Bulk

302 €

IMG-292
related products

WB Erklärungen der Abkürzungen ansehen.
Rabbit IgG SR: human
Immunogen: synthetic peptide corresponding to amino acids 771-787 of human Stat5B
Imgenex
Icon Datasheet
100 µg

Buy Bulk

302 €

IMG-6325A
related products

IHC ( paraffin ) , WB Erklärungen der Abkürzungen ansehen.
Beta-arrestin-2, or ARRB2, is an adaptor protein belonging to the arrestin family with an N- arrestin domain and a C- arrestin domain. ARRB2 is a regulatory protein involved in heterotrimeric G protein-coupled receptor desensitization and is known to regulate beta2-adrenergic receptor (beta2AR) function by enhancing beta2AR mediated nuclear translocation of ERK. ARRB2 binds to phosphorylated beta2ARs, thereby causing a significant impairment of their capacity to activate G(S) proteins. Along with AIP4, ARRB2 acts as an endosomal sorting molecule that mediates CXCR4 entry into a degradative pathway. It may also be involved in hormone-specific desensitization of TSH receptors. ARRB2 is a Ca2 binding protein of the retinal outer segments and binds to P-rhodopsin and is also involved in synaptic transmission in photoreceptor cells. It is widely expressed in most of the tissues, especially neuronal tissues and spleen.

Rabbit Ig SR: cow, dog, horse, human, monkey, mouse, rat
Immunogen: a peptide sequence corresponding to amino acids 23-40 of human ARRB2
Imgenex
Icon Datasheet
100 µg

Buy Bulk

302 €

IMG-528
related products

IF / ICC, WB Erklärungen der Abkürzungen ansehen.
Rabbit IgG SR: human, mouse
Immunogen: synthetic peptide corresponding to amino acids 251-266 of human Nak1
Imgenex
Icon Datasheet
200 µl

Buy Bulk

337 €

IMG-535
related products

WB Erklärungen der Abkürzungen ansehen.
Rabbit IgG SR: human, mouse
Immunogen: synthetic peptide corresponding to amino acids 323-340 of human TRAF3
Imgenex
Icon Datasheet
200 µl

Buy Bulk

302 €

IMG-5762
related products

IHC  ( frozen ) , IHC  ( paraffin ) , IP, WB Erklärungen der Abkürzungen ansehen.
Rabbit SR: human
Immunogen: synthetic peptide
Imgenex
Icon Datasheet
50 µl

Buy Bulk

267 €

IMG-5763
related products

IHC  ( frozen ) , IHC  ( paraffin ) , IP, WB Erklärungen der Abkürzungen ansehen.
Rabbit SR: gerbil, human, mouse, rat
Immunogen: recombinant protein fragment corresponding to the cytoplasmic end of human TRAF3 (amino acids 341-568)
Imgenex
Icon Datasheet
50 µl

Buy Bulk

267 €

IMG-246
related products

IF / ICC, IP, WB Erklärungen der Abkürzungen ansehen.
Mouse IgG1 kappa SR: human, mouse
Immunogen: full length human p73
Imgenex
Icon Datasheet
200 µl

Buy Bulk

337 €

IMG-259A
related products

ChIP, IF / ICC, IP, WB Erklärungen der Abkürzungen ansehen.
Mouse IgG1 kappa SR: human, mouse
Imgenex
Icon Datasheet
200 µl

Buy Bulk

337 €

IMG-260
related products

WB Erklärungen der Abkürzungen ansehen.
Mouse IgG SR: human
Immunogen: full length human p73
Imgenex
Icon Datasheet
200 µl

Buy Bulk

302 €

IMG-313A
related products

ChIP, IHC  ( paraffin ) , WB Erklärungen der Abkürzungen ansehen.
Mouse IgG1 kappa SR: human, mouse, rat
Immunogen: synthetic peptide
Imgenex
Icon Datasheet
100 µg

Buy Bulk

337 €

IMG-5355A
related products

WB Erklärungen der Abkürzungen ansehen.
p73 was identified as a long-lost cousin of tumor suppressor protein, p53. Homology between p53, p63, and p73 (approximately 63% amino acid identity in the DNA-binding domain) suggests that they may have overlapping functions.

Rabbit IgG SR: human
Immunogen: a portion of amino acids 75-125, containing a phosphorylated tyrosine residue at position 99, of human p73
Imgenex
Icon Datasheet
20 µg

Buy Bulk

348 €

IMG-5356A
related products

WB Erklärungen der Abkürzungen ansehen.
Rabbit Ig SR: human
Immunogen: synthetic peptide
Imgenex
Icon Datasheet
100 µg

Buy Bulk

302 €

IMG-6078A
related products

WB Erklärungen der Abkürzungen ansehen.
Rabbit IgG SR: cow, dog, human, mouse, rat
Immunogen: synthetic peptide
Imgenex
Icon Datasheet
100 µg

Buy Bulk

302 €

IMG-120A
related products

FC  ( Cell Surface ) , IF / ICC, IHC  ( paraffin ) , WB Erklärungen der Abkürzungen ansehen.
Rabbit IgG SR: human
Imgenex
Icon Datasheet
200 µl

Buy Bulk

337 €

IMG-120E
related products

FC  ( Cell Surface ) , IF / ICC, IHC  ( paraffin ) , WB Erklärungen der Abkürzungen ansehen.
Rabbit IgG SR: human
Imgenex
Icon Datasheet
200 µl

Buy Bulk

337 €

IMG-6221A
related products

WB Erklärungen der Abkürzungen ansehen.
Rabbit IgG SR: human
Immunogen: synthetic peptide corresponding to amino acids 228-242 of human MAPRE1
Imgenex
Icon Datasheet
100 µg

Buy Bulk

302 €

IMG-6221E
related products

WB Erklärungen der Abkürzungen ansehen.
EB1 is a microtubule-associated protein that interacts with the colorectal adenomatous polyposis coli tumor-suppressor protein and plays important roles in regulating microtubule dynamics, cell polarity, and chromosome stability.

Rabbit IgG SR: human
Immunogen: synthetic peptide corresponding to amino acids 228-242 of human MAPRE1
Imgenex
Icon Datasheet
100 µg

Buy Bulk

302 €

IMG-5846A
related products

WB Erklärungen der Abkürzungen ansehen.
Rabbit IgG SR: chimpanzee, human
Immunogen: synthetic peptide
Imgenex
Icon Datasheet
100 µg

Buy Bulk

337 €

IMG-5196A
related products

WB Erklärungen der Abkürzungen ansehen.
SMT3 is a Ubiquitin-like protein found in Saccharomyces cerevisiae similar to the mammalian Ubiquitin-like protein SUMO-1, which is involved in posttranslational protein modification. SMT3 is functionally active in regulation of nucleocytoplasmic transport and suggest a role in cell-cycle regulation. Knockdown of SMT3 in Drosophila in the prothoracic gland, which controls key developmental processes through the synthesis and release of ecdysteroids, caused a 4-fold prolongation of larval life and completely blocked the transition from larval to pupal stages.

Rabbit IgG SR: chimpanzee, horse, human, monkey, mouse
Immunogen: a portion of amino acids 50-95 of human SMT3
Imgenex
Icon Datasheet
100 µg

Buy Bulk

302 €

IMG-6290A
related products

WB Erklärungen der Abkürzungen ansehen.
AIRE is a transcriptional regulator protein that binds to DNA as a dimer and tetramer. AIRE is involved in immune regulation and is known to mediate E3 ubiquitin ligase activity.

Rabbit IgG SR: chimpanzee, human
Immunogen: synthetic peptide
Imgenex
Icon Datasheet
100 µg

Buy Bulk

302 €

IMG-5843A
related products

WB Erklärungen der Abkürzungen ansehen.
Rabbit IgG SR: bovine, chicken, chimpanzee, dog, human, mouse, rat, rhesus monkey
Immunogen: synthetic peptide
Imgenex
Icon Datasheet
100 µg

Buy Bulk

302 €

IMG-479
related products

WB Erklärungen der Abkürzungen ansehen.
Rabbit IgG SR: human, mouse, rat
Immunogen: synthetic peptide corresponding to amino acids 30-46 of human SIRT5
Imgenex
Icon Datasheet
100 µg

Buy Bulk

302 €

IMG-6047A
related products

WB Erklärungen der Abkürzungen ansehen.
Rabbit Ig SR: chimpanzee, cow, dog, horse, human
Immunogen: synthetic peptide
Imgenex
Icon Datasheet
100 µl

Buy Bulk

302 €

IMG-5987A
related products

WB Erklärungen der Abkürzungen ansehen.
Rabbit Ig SR: chicken, chimpanzee, cow, dog, human, monkey, rat
Immunogen: synthetic peptide
Imgenex
Icon Datasheet
100 µg

Buy Bulk

302 €

IMG-6284A
related products

WB Erklärungen der Abkürzungen ansehen.
Edg-1 is a heterotrimeric orphan receptor for lysosphingolipid sphingosine 1-phosphate (S1P). Human Edg-1 is a highly inducible and abundant endothelial cell GPR that helps in the regulation of differentiation of endothelial cells.

Rabbit IgG SR: human
Immunogen: synthetic peptide
Imgenex
Icon Datasheet
100 µg

Buy Bulk

302 €

IMG-6568A
related products

WB Erklärungen der Abkürzungen ansehen.
S1PR1 (Sphingosine-1-phosphate receptor 1) is also known as Endothelial differentiation G-protein coupled receptor 1. It is the receptor for, and binds to, the lipid signaling molecule Sphingosine 1-phosphate (S1P) with high affinity and specificity, and is suggested to be involved in regulatory processes of differentiation of endothelial cells and cell-cell adhesion. S1P is a bioactive lysophospholipid that elicits diverse physiological effect on most types of cells and tissues. This inducible epithelial cell G-protein-coupled receptor may be involved in the processes that regulate the differentiation of endothelial cells. It seems to be coupled to the G (i) subclass of heteromeric G proteins.

Rabbit IgG SR: human, rat
Immunogen: portion of amino acids 350 to 400 of human S1PR1
Imgenex
Icon Datasheet
100 µg

Buy Bulk

302 €

IMG-459
related products

IHC  ( paraffin ) , WB Erklärungen der Abkürzungen ansehen.
Rabbit IgG SR: human, mouse
Immunogen: synthetic peptides of human PUMAalpha (CT) (P53 Upregulated Modulator of Apoptosis)
Imgenex
Icon Datasheet
100 µg

Buy Bulk

302 €

IMG-464
related products

WB Erklärungen der Abkürzungen ansehen.
Rabbit IgG SR: human, mouse
Immunogen: synthetic peptides of human PUMAgamma (P53 Upregulated Modulator of Apoptosis)
Imgenex
Icon Datasheet
200 µl

Buy Bulk

302 €

IMG-291
related products

WB Erklärungen der Abkürzungen ansehen.
Rabbit IgG SR: human
Immunogen: synthetic peptide corresponding to amino acids 830-849 of human Stat2
Imgenex
Icon Datasheet
100 µg

Buy Bulk

302 €

IMG-309
related products

WB Erklärungen der Abkürzungen ansehen.
Rabbit IgG SR: human
Immunogen: synthetic peptides corresponding to amino acids 175-188, 525-540, and 567-580 of human IKKi/e protein It has tested negative on mouse NIH 3T3 cells
Imgenex
Icon Datasheet
100 µg

Buy Bulk

302 €

IMG-6492A
related products

IHC ( paraffin ) , WB Erklärungen der Abkürzungen ansehen.
Nestin is a type IV intermediate filament protein expressed by neuroepithelial stem cells and which has been proposed to represent a marker for putative islet stem cells. It is a high molecular weight protein with a terminus greater than 500 residues. Nestins are expressed by several types of cells during development, mostly in dividing cells of the Central Nervous System, Peripheral Nervous System and myogenic tissues. It also represents the progenitor population of neural stem cell origin. The role of nestin in dynamic cells, particularly structural organization of the cell, appears strictly regulated by phosphorylation, especially its integration into heterogeneous intermediate filaments together with vimentin or a-internexin. Nestin has recently received attention as a marker for detecting newly formed endothelial cells.

Rabbit IgG SR: chimpanzee, human
Immunogen: a portion of amino acids 1450-1500 of human Nestin
Imgenex
Icon Datasheet
100 µg

Buy Bulk

302 €

IMG-586
related products

WB Erklärungen der Abkürzungen ansehen.
Rabbit IgG SR: human
Immunogen: synthetic peptide corresponding amino acids 379-389 of human JNK2
Imgenex
Icon Datasheet
100 µg

Buy Bulk

302 €

IMG-6281A
related products

WB Erklärungen der Abkürzungen ansehen.
RORA binds to the retinoic acid response element and thus regulates gene expression and also controls cell function. It interacts with NM23-2, NM23-1, CDK7, NCOA3 and NCOA6 coactivators.

Rabbit Ig SR: chicken, chimpanzee, bovine, horse, human, monkey, mouse, opossum
Immunogen: synthetic peptide
Imgenex
Icon Datasheet
100 µg

Buy Bulk

302 €

IMG-6282A
related products

WB Erklärungen der Abkürzungen ansehen.
RORA binds to the retinoic acid response element and thus regulates gene expression and also controls cell function. It interacts with NM23-2, NM23-1, CDK7, NCOA3 and NCOA6 coactivators.

Rabbit Ig SR: chicken, chimpanzee, bovine, dog, horse, human, mouse
Immunogen: synthetic peptide
Imgenex
Icon Datasheet
100 µg

Buy Bulk

302 €

IMG-6476A
related products

WB Erklärungen der Abkürzungen ansehen.
OCT1/OTF1 is a protein belonging to the POU domain of transcription factors. OCT1, Octamer binding transcription factor 1, binds to an octamer motif and activates the promoters of the genes for some small nuclear RNAs (snRNA) and of genes for immunoglobulins.

Rabbit Ig SR: bovine, horse, human, mouse, rat
Immunogen: synthetic peptide (portion of amino acids 410-460 of human OCT1/OTF1)
Imgenex
Icon Datasheet
100 µg

Buy Bulk

302 €

IMG-6501A
related products

IHC ( paraffin ) , WB Erklärungen der Abkürzungen ansehen.
OCT-1, Octamer binding transcription factor 1 binds to an octamer motif (5-ATTTGCAT-3) and activates the promoters of the genes for some small nuclear RNAs (snRNA) and of genes for immunoglobulins. POU domain proteins contain a bipartite DNA-binding domain, which is divided by a flexible linker that enables them to adopt various monomer configurations on DNA. The versatility of POU protein operation is conferred at the dimerization level. POU dimer from the OCT-1 gene formed on the palindromic OCT factor recognition element, or PORE, could recruit the transcriptional coactivator OBF1. This octamer sequence within immunoglobulin promoters are sufficient for lymphoid-specific promoter activity in lymphoid cells. Oct-1 regulates the expansion and/or maintenance of mature B cells. In its absence mature B-cell pull is strongly reduced.

Rabbit IgG SR: chimpanzee, dog, horse, human
Immunogen: a portion of amino acids 1-50 of human OCT-1
Imgenex
Icon Datasheet
100 µg

Buy Bulk

302 €

IMG-6886A
IHC ( paraffin ) , WB Erklärungen der Abkürzungen ansehen.
SPARC, also called Osteonectin, is an extracellular matrix (ECM) associated glycoprotein. SPARC activates matrix metalloproteinase-2, a key effector of ECM proteolysis, a process linked to enhanced tumor invasion and metastatic potential. MMP expression by tumor cells themselves may be representative of more invasive migratory cancers or latter stages of tumor progression. SPARC appears to enhance MMP-2 activation at least in invasive breast cancer cell lines. Levels of SPARC expression appear to be directly correlated with progressive cancers not only of breast, but colon, kidney, ovary and brain. SPARC specific antibody may establish levels of expression of SPARC providing its use as a biomarker of late stage or aggressive tumors.

Rabbit IgG SR: human, monkey
Immunogen: A portion of amino acids 150-200 of human SPARC
Imgenex
Icon Datasheet
100 µg

Buy Bulk

302 €

IMG-6887A
IHC ( paraffin ) , WB Erklärungen der Abkürzungen ansehen.
SPARC, also called Osteonectin, is an extracellular matrix (ECM) associated glycoprotein. SPARC activates matrix metalloproteinase-2, a key effector of ECM proteolysis, a process linked to enhanced tumor invasion and metastatic potential. MMP expression by tumor cells themselves may be representative of more invasive migratory cancers or latter stages of tumor progression. SPARC appears to enhance MMP-2 activation at least in invasive breast cancer cell lines. Levels of SPARC expression appear to be directly correlated with progressive cancers not only of breast, but colon, kidney, ovary and brain. SPARC specific antibody may establish levels of expression of SPARC providing its use as a biomarker of late stage or aggressive tumors.

Rabbit IgG SR: human
Immunogen: A portion of amino acids 25-75 of human SPARC
Imgenex
Icon Datasheet
100 µg

Buy Bulk

302 €

IMG-5679
related products

IHC  ( frozen ) , IHC  ( paraffin ) , IP, WB Erklärungen der Abkürzungen ansehen.
Rabbit SR: human
Immunogen: synthetic peptide
Imgenex
Icon Datasheet
50 µl

Buy Bulk

267 €

IMG-103A
related products

IHC  ( paraffin ) , WB Erklärungen der Abkürzungen ansehen.
Mouse IgG SR: human
Imgenex
Icon Datasheet
100 µg

Buy Bulk

337 €

IMG-6013A
related products

WB Erklärungen der Abkürzungen ansehen.
Rabbit Ig SR: chimpanzee, human
Immunogen: synthetic peptide
Imgenex
Icon Datasheet
100 µg

Buy Bulk

302 €

IMG-6275AF488
FC ( IC )  Erklärungen der Abkürzungen ansehen.
ROR-gamma may be essential for lymphoid organogenesis and may play a role in controlling apoptosis during thymopoiesis.

Mouse IgG1 kappa SR: chimpanzee, human, mouse
Immunogen: synthetic peptide corresponding to a portion of amino acids 1-50 of human RORg
Imgenex
Icon Datasheet
100 Tests

Buy Bulk

395 €

IMG-6275C
FC ( IC )  Erklärungen der Abkürzungen ansehen.
ROR-gamma may be essential for lymphoid organogenesis and may play a role in controlling apoptosis during thymopoiesis.

Mouse IgG1 kappa SR: chimpanzee, human, mouse
Immunogen: synthetic peptide corresponding to a portion of amino acids 1-50 of human RORg
Imgenex
Icon Datasheet
100 Tests

Buy Bulk

395 €

IMG-6275D
FC  ( IC )  Erklärungen der Abkürzungen ansehen.
The specific functions of this protein are not known. However, reports suggest that this protein is a ligand activated transcription factor and may be essential for lymphoid organogenesis.

Mouse IgG1 SR: chimpanzee, human, mouse
Immunogen: synthetic peptide corresponding to amino acids 2-27
Imgenex
Icon Datasheet
100 tests

Buy Bulk

395 €

IMG-6275G
FC  ( IC )  Erklärungen der Abkürzungen ansehen.
The specific functions of this protein are not known. However, reports suggest that this protein is a ligand activated transcription factor and may be essential for lymphoid organogenesis.

Mouse IgG1 SR: chimpanzee, human, mouse
Immunogen: synthetic peptide corresponding to amino acids 2-27
Imgenex
Icon Datasheet
100 tests

Buy Bulk

395 €

IMP-121
hRORgamma expression Erklärungen der Abkürzungen ansehen.
Mammalian expression vector construct, pCMV/hRORgamma, containing coding sequence of human RAR-related orphan receptor gamma (GenBank Accession: NM_005060)
Imgenex
Icon Datasheet
10 µg

Buy Bulk

500 €

IMP-122
hRORgamma ( t )  expression Erklärungen der Abkürzungen ansehen.
Mammalian expression vector construct, pCMV/hRORgamma(t), containing coding sequence of human RAR-related orphan receptor gamma(t) (GenBank Accession: NM_001001523)
Imgenex
Icon Datasheet
10 µg

Buy Bulk

500 €

IMP-124
The ROR gamma (t) [del. 5-8] Plasmid (IMP-124) is a mammalian expression vector construct, pCMV/hRORgamma (t) [del. 5-8], containing coding sequence of a novel isoform of human RAR-related orphan receptor gamma (t) which lacks the hinge-encoding exons 5 - 8 and represses IL-17A gene transcription.
Imgenex
Icon Datasheet
10 µg

Buy Bulk

500 €

IMG-321A
related products

FC  ( Cell Surface ) , FC  ( Intracellular ) , WB Erklärungen der Abkürzungen ansehen.
Mouse IgG1 kappa SR: human, mouse
Immunogen: synthetic peptide of human TLR8
Imgenex
Icon Datasheet
100 µg

Buy Bulk

337 €

IMG-321AF488
FC ( CS,IC )  Erklärungen der Abkürzungen ansehen.
The TLR family is a phylogenetically conserved mediator of innate immunity that is essential for microbial recognition.

Mouse IgG1 kappa SR: human, mouse
Immunogen: synthetic peptide
Imgenex
Icon Datasheet
100 µg

Buy Bulk

395 €

IMG-321AF647
FC ( CS ) , FC ( IC )  Erklärungen der Abkürzungen ansehen.
The Toll-like receptor (TLR) family in mammal comprises a family of transmembrane proteins characterized by multiple copies of leucine rich repeats in the extracellular domain and IL-1 receptor motif in the cytoplasmic domain. Like its counterparts in Drosophila, TLRs signal through adaptor molecules. The TLR family is a phylogenetically conserved mediator of innate immunity that is essential for microbial recognition. Ten human homologs of TLRs (TLR1-10) have been described. TLR8 gene contains three exons, two of which have coding function. TLR8 cDNA codes for a protein of approximate molecular weight of 120 kDa (4,5).

Mouse IgG1 kappa SR: human, mouse
Immunogen: synthetic peptide of human TLR8, within amino acids 750-850
Imgenex
Icon Datasheet
100 µg

Buy Bulk

395 €

IMG-321B
related products

FC  ( Cell Surface ) , FC  ( Intracellular ) , WB Erklärungen der Abkürzungen ansehen.
Mouse IgG1 kappa SR: human, mouse
Immunogen: synthetic peptide of human TLR8
Imgenex
Icon Datasheet
100 µg

Buy Bulk

348 €

IMG-321C
related products

FC  ( Cell Surface ) , FC  ( Intracellular )  Erklärungen der Abkürzungen ansehen.
Mouse IgG1 kappa SR: human, mouse
Immunogen: synthetic peptide of human TLR8, within amino acids 750-850
Imgenex
Icon Datasheet
100 µg

Buy Bulk

348 €

IMG-321D
related products

FC  ( Cell Surface ) , FC  ( Intracellular )  Erklärungen der Abkürzungen ansehen.
Mouse IgG1 kappa SR: human, mouse
Immunogen: synthetic peptide of human TLR8, within amino acids 750-850
Imgenex
Icon Datasheet
100 µg

Buy Bulk

348 €

IML-108
Agonist screening, functional assays Erklärungen der Abkürzungen ansehen.
Stably co-transfected cell line which expresses human Toll-like receptor 8 (TLR8) and the secreted alkaline phosphatase (SEAP) reporter gene under the transcriptional control of an NF-kappaB response element.
Imgenex
Icon Datasheet
1 each

Buy Bulk

1223 €

IML-208
FC calibration, control Erklärungen der Abkürzungen ansehen.
TLR8/HEK 293 is a stably transfected cell line which expresses full-length human Toll-like receptor 8 (TLR8) with an N-terminal HA tag.
Imgenex
Icon Datasheet
1 each

Buy Bulk

947 €

IMG-6321A
FC ( CS ) , IF / ICC, IHC ( frozen )  Erklärungen der Abkürzungen ansehen.
CD19 is an important protein for B-cell antigen receptor signaling and regulation and also acts as a specialized adaptor protein for the amplification of Src family needed for this purpose.

Mouse IgG1 SR: human
Immunogen: synthetic peptide
Imgenex
Icon Datasheet
100 µg

Buy Bulk

115 €

IMG-6321AF647
FC  ( CS )  Erklärungen der Abkürzungen ansehen.
A major function of CD19 is to assemble with the antigen receptor of B lymphocytes to enhance the specificity and sensitivity of B cells towards antigens.

Mouse IgG1 SR: human
Imgenex
Icon Datasheet
100 tests

Buy Bulk

220 €

IMG-6321C
FC  ( CS )  Erklärungen der Abkürzungen ansehen.
A major function of CD19 is to assemble with the antigen receptor of B lymphocytes to enhance the specificity and sensitivity of B cells towards antigens.

Mouse IgG1 SR: human
Imgenex
Icon Datasheet
100 tests

Buy Bulk

197 €

IMG-6321D
FC  ( CS ) , IF / ICC, IHC  ( frozen )  Erklärungen der Abkürzungen ansehen.
A major function of CD19 is to assemble with the antigen receptor of B lymphocytes to enhance the specificity and sensitivity of B cells towards antigens.

Mouse IgG1 SR: human
Imgenex
Icon Datasheet
100 tests

Buy Bulk

197 €

IMG-496
related products

WB Erklärungen der Abkürzungen ansehen.
Rabbit IgG SR: human
Immunogen: mixture of synthetic peptides containing amino acids 45-69 and 595-608 of human PRMT4
Imgenex
Icon Datasheet
200 µl

Buy Bulk

302 €

IMG-6489A
related products

IHC ( paraffin ) , WB Erklärungen der Abkürzungen ansehen.
SOX9 has a role in sex determination and differentiation of Sertoli cells. It is involved in chondrogenesis and regulates the expression of other genes involved in chondrogenesis by acting as a transcription factor for these genes. Translocation of this gene can cause campomelic dysplasia. SOX9 is involved in the formation of testes from the indifferent fetal gonads. It is a major molecular component of the neuron-glia switch in developing spinal cord. During normal development, SOX9 allows the prostate epithelium to outgrow into the mesenchyme and then provides basal cell support for development and maintenance of the luminal epithelium. These functions of SOX9 are subverted in prostate cancer to support tumor growth and invasion. SOX9 may direct the formation of neural crest precursors and the development of a range of neural crest derivative. It has a transcriptional regulation in melanin production in cells. Northern blot analysis shows its expression on adult testis, adult heart, and fetal brain.

Rabbit IgG SR: cat, chimpanzee, dog, goat, human, mouse, rat
Immunogen: a portion of amino acids 225-275 of human SOX9
Imgenex
Icon Datasheet
100 µg

Buy Bulk

302 €

IMG-303-1
related products

IHC  ( paraffin ) , WB Erklärungen der Abkürzungen ansehen.
Rabbit IgG SR: human, mouse, rat
Immunogen: synthetic peptides of human AIF. AIF = Apoptosis-Inducing Factor
Imgenex
Icon Datasheet
50 µg

Buy Bulk

348 €

IMG-5658
related products

IHC  ( frozen ) , IHC  ( paraffin ) , IP, WB Erklärungen der Abkürzungen ansehen.
Rabbit SR: cow, dog, human, mouse, rat
Immunogen: synthetic peptide
Imgenex
Icon Datasheet
50 µl

Buy Bulk

267 €

IMG-5162A
FC Erklärungen der Abkürzungen ansehen.
Rabbit Ig SR: human
Immunogen: synthetic peptide
Imgenex
Icon Datasheet
100 µl

Buy Bulk

337 €

IMG-6807A
WB Erklärungen der Abkürzungen ansehen.
RBCK1, also known as HOIL-1L, acts as an E3 ubiquitin-protein ligase, or as part of an E3 complex that contains a zf-RanBP (Zn-finger in Ran binding protein) and a zf-C3HC4 (RING finger) domain. RBCK1 catalyzes the ubiquitination and degradation of IRF3. Both RBCK1 and IRF3 are activated by viral infections and IRF3 is a prerequisite trigger for induction of type I Interferons. RBCK1 also negatively regulates TNF and IL1 induced NF-kappaB activation. Thus it appears RBCK1 and IRF3 interaction represents a controlling antiviral regulatory channel but also that RBCK1 and ubiquitination pathways also are related to NF-kB and its role as an anti-viral response pathway.

Rabbit IgG SR: chimpanzee, human, mouse, orangutan
Immunogen: portion of amino acids 150-200 from human RBCK1
Imgenex
Icon Datasheet
100 µg

Buy Bulk

302 €

IMG-333
related products

WB Erklärungen der Abkürzungen ansehen.
Rabbit IgG SR: human
Immunogen: synthetic peptide of human CCR5
Imgenex
Icon Datasheet
100 µg

Buy Bulk

302 €

IMG-124A
related products

ELISA, IF / ICC, IHC  ( frozen ) , IP, WB Erklärungen der Abkürzungen ansehen.
Mouse IgG1 kappa SR: human, mouse, muntjac (deer), rat
Immunogen: Baculovirus expressed His-tagged full length TRF2 protein
Imgenex
Icon Datasheet
100 µg

Buy Bulk

337 €

IMG-148A
ChIP, IP, WB Erklärungen der Abkürzungen ansehen.
Goat IgG SR: human, mouse
Imgenex
Icon Datasheet
100 µg

Buy Bulk

337 €

IMG-6302A
related products

WB Erklärungen der Abkürzungen ansehen.
MERTK may have a functional role in filovirus infection, where it may act as a cell entry factor. MERTK is a GAS6 receptor, participating through binding to GAS6 in platelet function and platelet dependent thrombosis in vitro.

Rabbit IgG SR: chimpanzee, human, mouse
Immunogen: synthetic peptide corresponding to amino acids 72-89
Imgenex
Icon Datasheet
100 µg

Buy Bulk

302 €

IMG-265A
related products

WB Erklärungen der Abkürzungen ansehen.
Bif-1 (Bax interacting factor-1) is also known as Endophilin B1, IP: Takahashi Y et al. Nat Cell Biol. 2007 Oct,9(10):1142-51.

Mouse IgG SR: human
Imgenex
Icon Datasheet
100 µg

Buy Bulk

337 €

IMG-6467A
related products

WB Erklärungen der Abkürzungen ansehen.
SOX2 (SRY-RELATED HMG-BOX GENE 2), the basic helix-loop-helix transcription factor, is indispensable for maintaining embryonic stem (ES) cell pluripotency. The gene expresses in self-renewing progenitor cells and acts to inhibit neuronal differentiation.

Rabbit Ig SR: cat, chicken, chimpanzee, human, mouse, swine, rhesus monkey
Immunogen: synthetic peptide (portion of amino acids 100-150 of human SOX2)
Imgenex
Icon Datasheet
100 µg

Buy Bulk

302 €

IMG-6137A
related products

WB Erklärungen der Abkürzungen ansehen.
RGS19 is a member of the RGS protein family, which acts as a GTPase-activating protein (GAPs) for heterotrimeric G proteins, increasing the intrinsic rate of GTP hydrolysis and accelerating signal termination.

Rabbit IgG SR: human, mouse
Immunogen: synthetic peptide
Imgenex
Icon Datasheet
100 µg

Buy Bulk

337 €

IMG-555
related products

WB, IHC Erklärungen der Abkürzungen ansehen.
Rabbit IgG SR: human, monkey, mouse, rat
Immunogen: synthetic peptides corresponding to amino acids 85-99 and 372-388 of human Smad6
Imgenex
Icon Datasheet
200 µl

Buy Bulk

337 €

IMG-438
related products

WB Erklärungen der Abkürzungen ansehen.
WB: 1-2 ug/ml

Rabbit IgG SR: human
Immunogen: synthetic peptide corresponding to amino acids 361-372 of human c-IAP1
Imgenex
Icon Datasheet
100 µg

Buy Bulk

302 €

IMG-5715
related products

IHC  ( frozen ) , IHC  ( paraffin ) , IP, WB Erklärungen der Abkürzungen ansehen.
Rabbit SR: human
Immunogen: synthetic peptide
Imgenex
Icon Datasheet
50 µl

Buy Bulk

267 €

IMG-5716
related products

IHC  ( frozen ) , IHC  ( paraffin ) , IP, WB Erklärungen der Abkürzungen ansehen.
Rabbit SR: dog, gerbil, human, mouse, rat
Immunogen: full-length recombinant human cAIP1
Imgenex
Icon Datasheet
50 µl

Buy Bulk

302 €

IMG-5717
related products

IHC  ( frozen ) , IHC  ( paraffin ) , IP, WB Erklärungen der Abkürzungen ansehen.
Rabbit SR: human
Immunogen: synthetic peptide
Imgenex
Icon Datasheet
50 µl

Buy Bulk

267 €

IMG-6882A
Flow ( CS ) , IHC ( paraffin )  Erklärungen der Abkürzungen ansehen.
CD86, also called B7-2, belongs to the immunoglobulin superfamily of proteins critical in driving innate and adaptive immune responses. CD86, along with CD80 present on antigen presenting cells such as dendritic cells (DCs) are costimulatory molecules in the immune synapse between such as DC-T cells. CD86 and CD80 serve as receptors for CD28, resulting in activation, while binding CTLA-4 may downregulate activation. CD86 engagement with CD28 presentation on T cells results in DC activation and triggering of key pro-inflammatory cytokine responses through NF-kB. Studies suggest differentiable roles of CD86 and CD80 in adaptive inflammatory responses through in vivo studies such as in graft rejection. Additional studies also indicate different roles of both CD86 and CD80 in innate immune responses such as in sepsis. In the latter study it appears that sepsis and initial septic shock, a pro-inflammatory cytokine storm notably comprised of IL-6, TNFa, and IL-1b, is associated with CD80 regulation, while CD86 contribution at least in this model was not as prominent.

Mouse IgG1 SR: human
Immunogen: Human lymphocytes.
Imgenex
Icon Datasheet
100 µg

Buy Bulk

150 €

IMG-290
related products

IF / ICC, WB Erklärungen der Abkürzungen ansehen.
Rabbit IgG SR: human
Immunogen: synthetic peptides corresponding to amino acids 44-60 and 187-198 of human PIASgamma PIAS = Protein Inhibitors of Activated STAT
Imgenex
Icon Datasheet
100 µg

Buy Bulk

302 €

IMG-5111A
related products

WB Erklärungen der Abkürzungen ansehen.
WB: 0.5-2 ug/ml

Rabbit IgG SR: mouse, human, rat
Immunogen: synthetic peptide corresponding to amino acids 195-209
Imgenex
Icon Datasheet
100 µg

Buy Bulk

302 €

IMG-178
related products

WB Erklärungen der Abkürzungen ansehen.
Rabbit IgG SR: human, mouse, rat
Immunogen: synthetic peptide corresponding to amino acids 233-248 of human MyD88
Imgenex
Icon Datasheet
100 µg

Buy Bulk

302 €

IMG-2005-1 MyD88 Homodimerization Inhibitory Peptide
inhibition of MyD88 dependent TLR / IL-​1R signaling activitiy Erklärungen der Abkürzungen ansehen.
The MyD88 Homodimerization Inhibitor peptide: 2 x 1 mg (lyophilized) DRQIKIWFQN RRMKWKKRDV LPGT (m.w. 3100). Control peptide: 2 x 1 mg (lyophilized) DRQIKIWFQN RRMKWKK (m.w. 2361)
Imgenex
Icon Datasheet
2 mg

Buy Bulk

499 €

IMG-2005-5
The MyD88 Homodimerization Inhibitor peptide: 5 x 1 mg (lyophilized) DRQIKIWFQN RRMKWKKRDV LPGT (m.w. 3100). Control peptide: 5 x 1 mg (lyophilized) DRQIKIWFQN RRMKWKK (m.w. 2361)
Imgenex
Icon Datasheet
5 mg

Buy Bulk

968 €

IMG-6495A
related products

WB Erklärungen der Abkürzungen ansehen.
Myeloid differentiation primary response protein MyD88 is a protein which in human is encoded by the MyD88 gene. MyD88 is a universal adaptor protein which interacts with all TLRs (except TLR3) and interleukin-1 receptors (IL-1Rs) to activate the transcription factor NF-kB. Functional studies show that MyD88 is involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response and acts via IRAK1, IRAK2 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Studies suggested that MyD88-dependant TLRs and IL-1Rs are essential for protective immunity to a limited number of pyogenic bacteria and enhance the host defense to most natural infections like common viral infections.

Rabbit IgG SR: human, mouse
Immunogen: a portion of amino acids 50-100 of human MyD88 was used as Immunogen.
Imgenex
Icon Datasheet
100 µg

Buy Bulk

302 €

IMG-339
related products

ChIP, IP, WB Erklärungen der Abkürzungen ansehen.
Rabbit IgG SR: human, mouse
Immunogen: synthetic peptide corresponding to amino acids 572-587 of human HDAC5
Imgenex
Icon Datasheet
100 µg

Buy Bulk

302 €

IMG-6550A
related products

IHC ( paraffin ) , WB Erklärungen der Abkürzungen ansehen.
Lin-28 homolog A is a protein that in humans is encoded by the LIN28 gene. It is a marker of undifferentiated human embryonic stem cells and has been used to enhance the efficiency of the formation of induced pluripotent stem (iPS) cells from human fibroblasts. It encodes a cytoplasmic mRNA-binding protein that binds to and enhances the translation of the Igf2 mRNA. LIN28 has also been shown to bind to the let-7 pre-miRNA and block production of the mature let-7 microRNA in mouse embryonic stem cells.

Rabbit IgG SR: human, mouse, rat
Immunogen: a portion of amino acids 100-150 of human LIN28
Imgenex
Icon Datasheet
100 µg

Buy Bulk

302 €

IMG-6367A
related products

WB Erklärungen der Abkürzungen ansehen.
eIF3J is an RNA-associated protein belonging to the eukaryotic translation initiation factor family. It belongs to the group of proteins involved in protein translation/synthesis where it binds to the 40S ribosomal subunit and promotes the binding of methionyl-tRNAi and mRNA to form the 40S initiation complex. eIF3J is a component of the eIF3 multiprotein complex, composed of at least 13 different subunits. It is also known to interact with eIF3S12. Ubiquitous expression is seen in most tissues.

Rabbit Ig SR: chimpanzee, dog, horse, human, mouse, orangutan
Immunogen: a portion of amino acids 230-280 of human eIF
Imgenex
Icon Datasheet
100 µg

Buy Bulk

302 €

IML-301
Agonist / antagonist screening Erklärungen der Abkürzungen ansehen.
IL-17A Prom/LUCPorter(TM) HEK293 is a stably transfected cell line which expresses SwitchGear's RenSP luciferase reporter gene under the transcriptional control of the IL-17A promoter. Induction of the IL-17A promoter by RORgammat has been demonstrated. RORgammat significantly mediated activation of the IL-17A promoter quantified by luciferase activity. This new cell line together with LightSwitch Lusiferase Assay Reagent (TM) (Catalog Nos. LS010 and LS100) from SwitchGear Genomics form a complete luciferase assay read-out system for studying the molecular signals and relative impact role of IL-17A in autoimmune models.
Imgenex
Icon Datasheet
1 vial

Buy Bulk

4108 €

IMG-6885A
IHC ( paraffin )  Erklärungen der Abkürzungen ansehen.
CLEC8A, also called LOX-1 or OLR1, is one of the original C-Lectin type receptors (CLRs) associated with the fungal pattern recognition receptor Dectin-1. The DECTIN-1 associated clusters, including LOX-1, are found in the mammalian natural killer gene complex (NKC). LOX-1 is an innate immune receptor expressed on a variety of cells including activated macrophages, platelets, smooth muscle endothelium and fibroblasts. Expression of LOX-1 is increased by pro-inflammatory milieus in autoimmune pathologies like diabetes or atherosclerosis or hyperlipidemia caused also by oxidative stress or oxLDL. As activating immunoreceptors, CLRs are type II transmembrane proteins with a single CTLD, a C-type lectin-like domain that recognizes proteins and not carbohydrates. Antibody to LOX-1 is useful for functional, phenotyping or structural studies.

Rabbit IgG SR: human
Immunogen: A portion of amino acids 150-200 of human LOX-1
Imgenex
Icon Datasheet
100 µg

Buy Bulk

302 €

IMG-540
related products

WB, IHC Erklärungen der Abkürzungen ansehen.
Rabbit IgG SR: human, mouse
Immunogen: synthetic peptide corresponding to amino acids 465-483 of human TLR7
Imgenex
Icon Datasheet
200 µl

Buy Bulk

302 €

IMG-581A
related products

FC  ( Cell Surface ) , FC  ( Intracellular ) , IF / ICC, IHC  ( frozen, paraffin ) , WB Erklärungen der Abkürzungen ansehen.
Rabbit IgG SR: human, mouse, rat
Immunogen: synthetic peptide corresponding to amino acids 706-728 of human TLR7
Imgenex
Icon Datasheet
100 µg

Buy Bulk

337 €

IMG-581C
Flow  ( Intracellular )  Erklärungen der Abkürzungen ansehen.
Stimulation of the NFkB signaling pathway by TLR7 suggests that it plays a role in immune response.

Rabbit IgG SR: human, mouse
Immunogen: synthetic peptide
Imgenex
Icon Datasheet
100 µg

Buy Bulk

348 €

IMG-581E
related products

FC  ( Cell Surface ) , FC  ( Intracellular ) , IHC  ( frozen ) , WB Erklärungen der Abkürzungen ansehen.
Rabbit IgG SR: human, mouse
Immunogen: synthetic peptide corresponding to amino acids 706-728 of human TLR7
Imgenex
Icon Datasheet
100 µg

Buy Bulk

348 €

IMG-6070A
related products

WB Erklärungen der Abkürzungen ansehen.
Rabbit IgG SR: chimpanzee, human, monkey
Immunogen: synthetic peptide
Imgenex
Icon Datasheet
100 µg

Buy Bulk

302 €

IMG-665A
related products

FC  ( Cell Surface ) , FC  ( Intracellular ) , IHC  ( frozen ) , WB Erklärungen der Abkürzungen ansehen.
Rabbit IgG SR: human, mouse
Immunogen: synthetic peptide
Imgenex
Icon Datasheet
100 µg

Buy Bulk

337 €

IMG-665C
related products

FC  ( Cell Surface, Intracellular ) , WB Erklärungen der Abkürzungen ansehen.
Rabbit IgG SR: human, mouse
Immunogen: synthetic peptide
Imgenex
Icon Datasheet
100 µg

Buy Bulk

348 €

IMG-665D
related products

FC  ( Cell Surface, Intracellular ) , WB Erklärungen der Abkürzungen ansehen.
Rabbit IgG SR: human, mouse
Immunogen: synthetic peptide
Imgenex
Icon Datasheet
100 µg

Buy Bulk

395 €

IMG-6675A
related products

FC ( IC ) , WB Erklärungen der Abkürzungen ansehen.
TLR7 is a 1049 amino acid long highly conserved membrane protein belonging to the Toll-like receptor (TLR) family with 27 LRR (leucine-rich) repeats and a TIR domain. It plays a fundamental role in pathogen recognition and activation of innate immunity. TLR7 is activated by infections with single-stranded RNA viruses, including influenza virus and vesicular stomatitis virus (VSV). It is predominantly expressed in lung, placenta, and spleen, and lies in close proximity to another family member, TLR8. It acts via MyD88 and TRAF6, leading to NF-kappaB activation, cytokine secretion and the inflammatory response. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity.

Mouse IgG1 kappa SR: human
Immunogen: a partial human TLR7 recombinant protein (amino acids 562-839)
Imgenex
Icon Datasheet
100 µg

Buy Bulk

337 €

IMG-6675AF488
FC ( IC )  Erklärungen der Abkürzungen ansehen.
TLR7 is a 1049 amino acid long highly conserved membrane protein belonging to the Toll-like receptor (TLR) family with 27 LRR (leucine-rich) repeats and a TIR domain. It plays a fundamental role in pathogen recognition and activation of innate immunity. TLR7 is activated by infections with single-stranded RNA viruses, including influenza virus and vesicular stomatitis virus (VSV). It is predominantly expressed in lung, placenta, and spleen, and lies in close proximity to another family member, TLR8. It acts via MyD88 and TRAF6, leading to NF-kappaB activation, cytokine secretion and the inflammatory response. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity.

Mouse IgG1 kappa SR: human
Immunogen: a partial human TLR7 recombinant protein (amino acids 562-839)
Imgenex
Icon Datasheet
100 tests

Buy Bulk

348 €

IML-107
Agonist screening, functional assays Erklärungen der Abkürzungen ansehen.
Stably co-transfected cell line which expresses human Toll-like receptor7 (TLR7) and the secreted alkaline phosphatase (SEAP) reporter gene under the transcriptional control of an NF-kappaB response element.
Imgenex
Icon Datasheet
1 each

Buy Bulk

1223 €

IML-207
FC calibration, control Erklärungen der Abkürzungen ansehen.
TLR7/HEK 293 is a stably transfected cell line which expresses full-length human Toll-like receptor 7 (TLR7) with an N-terminal HA tag.
Imgenex
Icon Datasheet
1 each

Buy Bulk

947 €

IMG-462
related products

WB Erklärungen der Abkürzungen ansehen.
Rabbit IgG SR: human
Immunogen: synthetic peptide corresponding to amino acids 806-826 of human STAT6 This sequence is 80% homologous in mouse and 85% homologous in rat
Imgenex
Icon Datasheet
200 µl

Buy Bulk

337 €

IMG-6249A
related products

WB, IF, ICC Erklärungen der Abkürzungen ansehen.
STAT6 is rapidly activated in response to IL-4, however the fate of the activated form is not clear.

Rabbit Ig SR: human, mouse, rat
Immunogen: synthetic peptide corresponding to amino acids 808-826 of human STAT6
Imgenex
Icon Datasheet
100 µg

Buy Bulk

302 €

IMG-6901A
IP, WB Erklärungen der Abkürzungen ansehen.
STAT6 is a member of the STAT (signal transducers and activators of transcription) family of transcription factors that regulate inflammation. Inflammation is a process whereby lymphoid and myeloid effector cells are recruited to the site of infection or injury. STAT6, like other family members, is activated by phosphorylation in response to a large number of extracellular signaling peptides including cytokines, interferons and growth factors. Phosphorylated STAT6 translocates from the cytoplasm to the nucleus where it regulates gene transcription of proteins involved in immune responses. STAT6, as part of its function in mediating cytokine signals, is also essential for hematopoiesis of immune effectors including the differentiation of certain T helper subsets. STATs are very involved in pathological processes. For example, STAT6 dependent Th2 development contributes to various inflammatory diseases including allergic asthma. Furthermore, constitutively active STAT6 predisposed mice to lymphoproliferative disease whereas the loss of STAT6 promoted a lupus-like autoimmune disease. The association of STATs with immune mediated diseases, including cancer, has been a strong driver for drug discovery programs targeting their signaling pathways in order to develop potential therapeutics. The specificity of the STAT6 antibody been validated in wild-type and STAT6 knockout mice wherein wild-type hepatocytes were antibody positive and knockout hepatocytes were antibody negative.

Mouse IgG1 SR: human, mouse
Immunogen: A portion of amino acids 600-650 of human STAT6
Imgenex
Icon Datasheet
100 µg

Buy Bulk

302 €

IMG-6350A
FC ( CS )  Erklärungen der Abkürzungen ansehen.
CD14 an important component of the innate immune response preferentially expressed on mature cells of the monocytic lineage mediates the bacterial lipopolysaccharide (LPS) signaling.

Mouse IgG1 kappa SR: human
Imgenex
Icon Datasheet
100 µg

Buy Bulk

115 €

IMG-6350AF647
FC  ( CS )  Erklärungen der Abkürzungen ansehen.
CD14 a well known cell-activating receptor for lipopolysaccharide-binding protein and peptidoglycan is an important regulator of lipopolysaccharide (LPS)-dependent signal transduction.

Mouse IgG1 SR: human
Imgenex
Icon Datasheet
100 tests

Buy Bulk

337 €

IMG-6350C
FC  ( CS )  Erklärungen der Abkürzungen ansehen.
CD14 a well known cell-activating receptor for lipopolysaccharide-binding protein and peptidoglycan is an important regulator of lipopolysaccharide (LPS)-dependent signal transduction.

Mouse IgG1 SR: human
Imgenex
Icon Datasheet
100 tests

Buy Bulk

220 €

IMG-6350E
FC ( CS )  Erklärungen der Abkürzungen ansehen.
CD14 an important component of the innate immune response preferentially expressed on mature cells of the monocytic lineage mediates the bacterial lipopolysaccharide (LPS) signaling.

Mouse IgG1 kappa SR: human
Imgenex
Icon Datasheet
100 µg

Buy Bulk

115 €

IMG-6053A
related products

WB Erklärungen der Abkürzungen ansehen.
Rabbit Ig SR: human, monkey
Immunogen: synthetic peptide
Imgenex
Icon Datasheet
100 µg

Buy Bulk

302 €

IMG-5118A
related products

WB Erklärungen der Abkürzungen ansehen.
WB: 1-3 ug/ml

Rabbit IgG SR: human
Immunogen: synthetic peptide corresponding to amino acids 315-332
Imgenex
Icon Datasheet
100 µg

Buy Bulk

302 €

IMG-5857A
related products

WB Erklärungen der Abkürzungen ansehen.
CRHR2 is a novel member of Secretin-family-GPCR proteins and is involved in stress responses, cardiovascular function and gastric motility.

Rabbit IgG SR: bovine, chicken, dog, human, mouse, rat
Immunogen: synthetic peptide
Imgenex
Icon Datasheet
100 µg

Buy Bulk

302 €

IMG-296A
related products

WB Erklärungen der Abkürzungen ansehen.
Mouse IgG1 kappa SR: human
Immunogen: synthetic peptide
Imgenex
Icon Datasheet
100 µg

Buy Bulk

337 €

IMG-6422A
related products

WB Erklärungen der Abkürzungen ansehen.
STING is a signaling protein and an important component of innate immune signaling. This protein is able to activate both NF-kappa-B and IRF3 transcription pathways.

Rabbit Ig SR: human
Immunogen: synthetic peptide
Imgenex
Icon Datasheet
100 µg

Buy Bulk

302 €

IMG-6485A
related products

IHC ( paraffin ) , WB Erklärungen der Abkürzungen ansehen.
STING is a 379 amino acid containing signaling protein that acts as an important component of innate immune signaling. This signaling protein is able to activate both NF-kappa-B and IRF3 transcription pathways to induce expression of type I interferon (IFN-alpha and IFN-beta) and exert a potent anti-viral state following expression. STING may have translocon function, the translocon possibly being able to influence the induction of type I interferons and is also involved in transduction of apoptotic signals via its association with the major histocompatibility complex class II (MHC-II) thus facilitating the detection of intracellular viral RNA species as well as B-form DNA and mediates death signaling via activation of the extracellular signal-regulated kinase (ERK) pathway. Generally seen in endoplasmic reticulum membrane, cell membrane and mitochondrion outer membrane, it is ubiquitously expressed in most of tissues.

Rabbit IgG SR: chimpanzee, human, mouse, rat, rhesus monkey
Immunogen: a portion of amino acids 310-360 of human STING
Imgenex
Icon Datasheet
100 µg

Buy Bulk

302 €

IMG-134
related products

WB Erklärungen der Abkürzungen ansehen.
Mouse IgG SR: human, mouse
Immunogen: GST fusion protein containing 62 glutamine amino acid repeat
Imgenex
Icon Datasheet
100 µg

Buy Bulk

302 €

IMG-506
related products

WB Erklärungen der Abkürzungen ansehen.
Rabbit IgG SR: human, mouse
Immunogen: mixture of synthetic peptides corresponding to human PRMT6 amino acid sequence PRMT: Protein aRginine MethylTransferase
Imgenex
Icon Datasheet
200 µl

Buy Bulk

302 €

IMG-5025
related products

IHC  ( paraffin ) , WB Erklärungen der Abkürzungen ansehen.
Rabbit IgG SR: human
Immunogen: synthetic peptide corresponding to amino acids 31-45 of human caspase-1
Imgenex
Icon Datasheet
200 µl

Buy Bulk

302 €

IMG-5028
related products

IHC  ( paraffin ) , WB Erklärungen der Abkürzungen ansehen.
Mouse IgG1 kappa SR: human, mouse
Immunogen: synthetic peptide corresponding to amino acids 371-390 of human caspase-1
Imgenex
Icon Datasheet
100 µg

Buy Bulk

337 €

IMG-6086A
related products

WB Erklärungen der Abkürzungen ansehen.
Rabbit IgG SR: human
Immunogen: synthetic peptide
Imgenex
Icon Datasheet
100 µg

Buy Bulk

302 €

IMG-5892A
related products

WB Erklärungen der Abkürzungen ansehen.
Rabbit IgG SR: chicken, chimpanzee, dog, human, rat
Immunogen: synthetic peptide
Imgenex
Icon Datasheet
100 µg

Buy Bulk

302 €

IMG-5710
related products

IHC  ( frozen ) , IHC  ( paraffin ) , IP, WB Erklärungen der Abkürzungen ansehen.
Rabbit SR: dog, gerbil, human, mouse, rat
Immunogen: synthetic peptide
Imgenex
Icon Datasheet
50 µl

Buy Bulk

267 €

IMG-5711
related products

IHC  ( frozen ) , IHC  ( paraffin ) , IP, WB Erklärungen der Abkürzungen ansehen.
Rabbit SR: human
Immunogen: synthetic peptide
Imgenex
Icon Datasheet
50 µl

Buy Bulk

267 €

IMG-5712
related products

IHC  ( frozen ) , IHC  ( paraffin ) , IP, WB Erklärungen der Abkürzungen ansehen.
Rabbit SR: human
Immunogen: recombinant full-length human caspase-10
Imgenex
Icon Datasheet
50 µl

Buy Bulk

267 €

IMG-6432A
related products

IHC ( paraffin ) , WB Erklärungen der Abkürzungen ansehen.
HDAC9 is a histone deacetylase with an important role in the regulation of gene expression and hematopoiesis. A nuclear protein, HDAC9 belongs to the histone deacetylase family with several isoforms and is inhibited by Trichostatin A (TSA) and suberoylanilide hydroxamic acid. It helps in deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4) and gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. MEF2-dependent transcription is repressed by HDAC9 by recruiting HDAC1 and/or HDAC3. It also inhibits skeletal myogenesis and is involved in heart development. Ubiquitous but variable expression is seen in brain and other tissues like heart, pancreas and also in human bladder carcinoma cells. Lack of HDAC9 protein is found in a family with Peters anomaly, a central corneal leukoma.

Rabbit IgG SR: chimpanzee, cow, dog, horse, human, mouse, opossum
Immunogen: a portion of amino acids 100-150 of human HDAC9
Imgenex
Icon Datasheet
100 µg

Buy Bulk

302 €

IMG-6799A
WB, FC ( IC )  Erklärungen der Abkürzungen ansehen.
DNA Damage Binding protein 1 (DDB1) binds with CUL4 to form an ubiquitin E3 ligase that targets protein substrates for ubiquitin-dependent proteolysis. Loss of DDB1 impedes the proteolysis of a grouping of CUL4 substrates at least in response to UV and CUL4 ubiquitinylation. DDB1 is highly conserved from yeast to mammals. DDB1 specific antibody probes might be useful in identifying CUL4-DDB1 substrates in epigenetics applications and ubiquitin modification dependent protein function.

Rabbit IgG SR: human, broad
Immunogen: portion of amino acids 385-435 from human DDB1
Imgenex
Icon Datasheet
100 µg

Buy Bulk

302 €

IMG-580
related products

WB Erklärungen der Abkürzungen ansehen.
Rabbit IgG SR: human, mouse, rat
Immunogen: synthetic peptide corresponding to a portion of human TLR5
Imgenex
Icon Datasheet
100 µg

Buy Bulk

302 €

IMG-663A
related products

FC  ( Cell Surface ) , FC  ( Intracellular ) , WB Erklärungen der Abkürzungen ansehen.
Mouse IgG2a SR: human, mouse
Immunogen: synthetic peptide corresponding to a portion of human TLR5
Imgenex
Icon Datasheet
100 µg

Buy Bulk

302 €

IMG-663C
FC  ( Cell Surface ) , FC  ( Intracellular )  Erklärungen der Abkürzungen ansehen.
Mouse IgG2a SR: dog, human, mouse
Immunogen: synthetic peptide corresponding to a portion of human TLR5
Imgenex
Icon Datasheet
100 µg

Buy Bulk

348 €

IMG-663D
FC  ( Cell Surface ) , FC  ( Intracellular )  Erklärungen der Abkürzungen ansehen.
Mouse IgG2a kappa SR: human, mouse
Immunogen: synthetic peptide corresponding to a portion of TLR5
Imgenex
Icon Datasheet
100 µg

Buy Bulk

395 €

IMG-664A
related products

FC  ( Cell Surface, Intracellular ) , IHC  ( frozen ) , WB Erklärungen der Abkürzungen ansehen.
Mouse IgG2a kappa SR: human, mouse
Immunogen: synthetic peptide
Imgenex
Icon Datasheet
100 µg

Buy Bulk

302 €

IMG-664AF488
FC ( CS ) , FC ( IC )  Erklärungen der Abkürzungen ansehen.
The Toll-like receptor (TLR) family in mammal comprises a family of transmembrane proteins characterized by multiple copies of leucine rich repeats in the extracellular domain and IL-1 receptor motif in the cytoplasmic domain. Like its counterparts in Drosophila, TLRs signal through adaptor molecules and could constitute an important and unrecognized component of innate immunity in humans. The TLR family is a phylogenetically conserved mediator of innate immunity that is essential for microbial recognition. TLRs characterized so far activate the MyD88/interleukin-1 receptor-associated kinase (IRAK) signaling pathway. Thirteen homologs of TLRs (TLR1-13) have been described. Toll-like receptor 5 (TLR5) expression is upregulated following exposure to bacteria or to the TLR5 agonist, flagellin. Gram-negative bacteria, stimulate monocyte/macrophage cells in a TLR5-specific, CD14-independent manner. The TLR5 receptor thus appears to be the principal means by which the innate immune system recognizes flagellated bacterial pathogens.

Mouse IgG2a kappa SR: dog, human, mouse
Immunogen: synthetic peptide corresponding to a portion of human TLR5 between amino acids 700-800
Imgenex
Icon Datasheet
100 µg

Buy Bulk

395 €

IMG-664AF647
FC ( CS ) , FC ( IC )  Erklärungen der Abkürzungen ansehen.
The Toll-like receptor (TLR) family in mammal comprises a family of transmembrane proteins characterized by multiple copies of leucine rich repeats in the extracellular domain and IL-1 receptor motif in the cytoplasmic domain. Like its counterparts in Drosophila, TLRs signal through adaptor molecules and could constitute an important and unrecognized component of innate immunity in humans. The TLR family is a phylogenetically conserved mediator of innate immunity that is essential for microbial recognition. TLRs characterized so far activate the MyD88/interleukin-1 receptor-associated kinase (IRAK) signaling pathway. Thirteen homologs of TLRs (TLR1-13) have been described. Toll-like receptor 5 (TLR5) expression is upregulated following exposure to bacteria or to the TLR5 agonist, flagellin. Gram-negative bacteria, stimulate monocyte/macrophage cells in a TLR5-specific, CD14-independent manner. The TLR5 receptor thus appears to be the principal means by which the innate immune system recognizes flagellated bacterial pathogens

Mouse IgG2a kappa SR: dog, human, mouse
Immunogen: synthetic peptide corresponding to a portion of human TLR5 between amino acids 700-800
Imgenex
Icon Datasheet
100 µg

Buy Bulk

395 €

IMG-664C
FC  ( Cell Surface, Intracellular )  Erklärungen der Abkürzungen ansehen.
Mouse IgG2a kappa SR: human, mouse
Immunogen: synthetic peptide
Imgenex
Icon Datasheet
100 µg

Buy Bulk

348 €

IMG-664D
FC  ( Cell Surface, Intracellular )  Erklärungen der Abkürzungen ansehen.
Mouse IgG2a kappa SR: human, mouse
Immunogen: synthetic peptide
Imgenex
Icon Datasheet
100 µg

Buy Bulk

302 €

IML-105
Agonist screening, functional assays Erklärungen der Abkürzungen ansehen.
Stably co-transfected cell line which expresses human Toll-like receptor 5 (TLR5) and the secreted alkaline phosphatase (SEAP) reporter gene under the transcriptional control of an NF-kappaB response element.
Imgenex
Icon Datasheet
1 each

Buy Bulk

1223 €

IML-205
FC calibration, control Erklärungen der Abkürzungen ansehen.
TLR5/HEK 293 is a stably transfected cell line which expresses full-length human Toll-like receptor 5 (TLR5) with an N-terminal HA tag.
Imgenex
Icon Datasheet
1 each

Buy Bulk

947 €

IMG-5659
related products

IHC  ( frozen ) , IHC  ( paraffin ) , IP, WB Erklärungen der Abkürzungen ansehen.
Rabbit SR: human
Immunogen: synthetic peptide
Imgenex
Icon Datasheet
50 µl

Buy Bulk

267 €

IMG-5660
related products

IHC  ( frozen ) , IHC  ( paraffin ) , IP, WB Erklärungen der Abkürzungen ansehen.
Rabbit SR: human
Immunogen: synthetic peptide
Imgenex
Icon Datasheet
50 µl

Buy Bulk

267 €

IMG-5661
related products

IHC  ( frozen ) , IHC  ( paraffin ) , IP, WB Erklärungen der Abkürzungen ansehen.
Rabbit SR: gerbil, human, mouse, rat
Immunogen: full-length recombinant human Apaf1 protein (amino acids 1-420)
Imgenex
Icon Datasheet
50 µl

Buy Bulk

267 €

IMG-6890A