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Anti-VCP

ART NR.: A300-589A (100 µl | 20 µg)

Hersteller: Bethyl

Datenblatt

Anwendungen: WB, IP

Format: antigen affinity purified

Wirt: Rabbit

Isotyp: IgG

Reaktivität: human, mouse (expected: rat, bovine, dog, horse, rabbit, guinea pig, swine, panda, orangutan, rhesus monkey, gorilla, chimpanzee, tasmanian devil, white-tufted-ear marmoset, crab-eating macaque, northern white-cheeked gibbon)

Immunogen: synthetic peptide. The epitope recognized by A300-589A maps to a region between residue 750 and the C-terminus (residue 806) of human Valosin-Containing Protein using the numbering given in entry NP_009057.1 (GeneID 7415).

Lagerung: +4°C

Versand: +4°C

UniProt ID: P55072 | Suche mit UniProt ID

KEGG ID: K13525 | Suche mit KEGG ID

Schlagworte: Anti-VCP, Anti-Valosin-Containing Protein, Anti-TERA, Anti-Transitional Endoplasmic Reticulum ATPase, Anti-p97, Anti-IBMPFD, Anti-Inclusion Body Myopathy associated with Paget Disease of Bone and Frontotemporal Dementia.

A300-589A

100 µl (20 µg)

385 €

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Bemerkungen: Valosin-containing protein (VCP) is a multifunctional protein that is proposed to be involved in vesicle transport and fusion for protein trafficking, 26S proteasome function in ubiquitin-based degradation pathways, and the assembly of peroxisomes. Mutations in the human VCP gene have been associated with diseases such as inclusion body myopathy, Paget disease of the bone, and frontotemporal dementia (IBMPFD). VCP can inhibit apoptosis and may play a role in tumorigenesis. VCP is also known as, Transitional Endoplasmic Reticulum ATPase, TER ATPase, TERA, 15S Mg (2plus)-ATPase p97subunit, IBMPFD, Inclusion Body Myopathy associated with Paget Disease of Bone and Frontotemporal Dementia, MGC8560, MGC131997, MGC148092.

Spezifikationen

VCP Antibody

Rabbit anti-VCP Antibody, Affinity Purified
VCP AntibodyVCP AntibodyVCP Antibody
VCP AntibodyVCP AntibodyVCP Antibody

Gene and Protein Information

Citations

Li JM, The p97-UFD1L-NPL4 Protein Complex Mediates Cytokine-induced I?B? Proteolysis Mol Cell Biol. 2013 Nov 18. WB
PubMed: 24248593
Tcherpakov M et al., Regulation of endoplasmic reticulum-associated degradation by RNF5-dependent ubiquitination of JNK-associated membrane protein (JAMP). J Biol Chem. 2009 May 1;284(18):12099-109. WB
PubMed: 19269966
Dong M et al., ERdj4 and ERdj5 are required for endoplasmic reticulum-associated protein degradation of misfolded surfactant protein C. Mol Biol Cell. 2008 Jun;19(6):2620-30. WB, IP
PubMed: 18400946

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