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Itraconazole | CAS 84625-61-6

ART NR.: Cay13288-25 (25 mg)
Cay13288-50 (50 mg)
Cay13288-100 (100 mg)
Cay13288-250 (250 mg)

Hersteller: Cayman

Datenblatt



MSDS

Anwendungen: Hedgehog signaling antagonist

CAS-Nr. : 84625-​61-​6 | Suche mit CAS-Nr.

MW: 705

Formel: C35H38Cl2N8O4

Reinheit: >95%

Format: crystalline solid

Lagerung: -20°C

Versand: +4°C

Schlagworte: 4-[4-[4-[4-[[2-(2,4-dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]-1-piperazinyl]phenyl]-2,4-dihydro-2-(1-methylpropyl)-3H-1,2,4-triazol-3-one

Cay13288-25

25 mg

33 €

Cay13288-50

50 mg

59 €

Cay13288-100

100 mg

107 €

Cay13288-250

250 mg

231 €

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Bemerkungen: The Hedgehog signaling pathway is critical for embryonic growth and patterning as well as stem cell and progenitor cell tissue homeostasis. Inappropriate Hedgehog activity has been linked to tumor formation. Itraconazole is a systemic antifungal agent with a distinct antagonist effect on Hedgehog signaling. With an IC50 value of 0.8 µM in vitro, itraconazole behaves as an inverse agonist downstream of Patched (Ptch), yet upstream of Smoothened (Smo) to disprupt Hedgehog signaling. Treatment with 100 mg/kg itraconazole twice per day has been shown to suppress the growth of medulloblastomas from a Ptchp53-/- murine allograft model in as few as five days.
Image Art Cay13288-25 Cayman Itraconazole

Die Preise verstehen sich exkl. Versandkosten, eventuell anfallender Kühlmittelpauschale sowie der jeweils geltenden Mehrwertsteuer.


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