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ART-NR PRODUKT HERSTELLER MENGE PREIS
A303-505A
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Transcription initiation factor TFIID subunit 1 (TAF1) is the largest component and core scaffold of the TFIID basal transcription factor complex. TAF1 contains novel N- and C-terminal Ser/Thr kinase domains which can autophosphorylate or transphosphorylate other transcription factors. TAF1 phosphorylates TP53 on 'Thr-55' which leads to MDM2-mediated degradation of TP53. It also phosphorylates GTF2A1 and GTF2F1 on Ser residues. TAF1 possesses DNA-binding activity and is essential for progression of the G1 phase of the cell cycle. Alternative names for TAF1 include cell cycle gene 1 protein, TBP-associated factor 250 kDa, p250, TAF(II)250, TAFII-250, TAFII250, BA2R, CCG1, CCGS, TAF2A. [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/P21675]

Rabbit IgG SR: human
Immunogen: synthetic peptide. The epitope recognized by A303-505A maps to a region between residue 1800 and 1850 of human Transcription Initiation Factor TFIID Subunit 1 using the numbering given in entry NP_620278.1 (GeneID 6872).
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A300-023A
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MSH6 is a component of the DNA mismatch repair (MMR) system that functions to recognize base-base mismatches and framshift mispairs. MSH6 forms a heterodimer with MSH2 and is also part of the BRCA1-associated genome surveillance complex (BASC). Mutations in MSH6 have been linked to endometrial carcinoma. Alternate names for MSH6 include DNA mismatch repair protein MSH6, MutS-alpha 160 kDa subunit, G/T mismatch ?binding protein, GTBP, GTMBP, HSAP, and HNPCC5.

Rabbit IgG SR: human
Immunogen: synthetic peptide. The epitope recognized by A300-023A maps to a region between residue 1300 and the C-terminus (residue 1360) of human MutS homolog 6 using the numbering given in entry NP_000170.1 (GeneID 2956).
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A300-929A
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Protein arginine methylation is a form of post-translational modification that is catalyzed by protein arginine methyltransferases (PRMTs). HMGA1a (high mobility group A) has been identified as a substrate of PRMT6. The identification of HMGA1 as a substrate suggests that PRMT6 is involved in chromatin structure organization and gene regulation. PRMT6 is also known as protein arginine N-methyl transferase 6, heterogeneous nuclear ribonucleoprotein methyltransferase-like protein 6, HRMT1L6, and FLJ10559.

Rabbit IgG SR: human
Immunogen: synthetic peptide. The epitope recognized by A300-929A maps to a region between residue 325 and the C-terminus (residue 375) of human Protein Arginine Methyltransferase 6 using the numbering given in entry AAK85733.1 (GeneID 55170).
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A302-539A
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Major CDK9 elongation factor-associated protein (MCEF) is also known as AFF4 AF4/FMR2 family member 4. This family of proteins includes the AF4 proto-oncogene and FMR2 (fragile X E mental retardation syndrome) nuclear proteins. MCEF is a component of the cyclin-dependent kinase pair (CDK9/cyclin T1) complex. A chromosomal aberration involving AFF4 is found in acute lymphoblastic leukemia (ALL). Alternative names for MCEF include ALL1-fused gene from chromosome 5q31 protein, protein AF-5q31, and AF5Q31.

Rabbit IgG SR: human
Immunogen: synthetic peptide. The epitope recognized by A302-539A maps to a region between residue 1113 and 1163 of human major CDK9 elongation factor-associated protein of human using the numbering given in entry NP_055238.1 (GeneID 27125).
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A301-991A
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Casein Kinase I alpha (CKI alpha) is a serine/threonine protein kinase involved in the wnt signaling pathway. It is part of the CK1 serine/threonine kinase family which includes CK1 alpha, CK1beta, CK1delta, CK1epsilon, and CK1gamma.

Rabbit IgG SR: human, mouse
Immunogen: synthetic peptide. The epitope recognized by A301-991A maps to a region between residue 287 and 337 of human casein kinase 1 alpha 1 using the numbering given in entry NP_001883.4 (GeneID 1452).
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A301-407A
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KANK2/SIP was first identified during a genome wide-screen for proteins that interact with the SRC transcriptional coactivator. KANK2/SIP was also identified by domain and phylogenetic analysis to be a member of the KANK ankyrin-repeat domain-containing protein family. KANK related proteins possess a conserved ankyrin-repeat and coiled-coil domain. KANK2, as well as other KANK proteins, appear to play a role in the formation of actin stress fibers. Alternate names for KANK2/SIP include KN motif and ankyrin repeat domain-containing protein 2, SRC-1-interacting protein, matrix-remodeling-associated protein 3, ankyrin repeat domain 25, ANKRD25, MXRA3, and KIAA1518.

Rabbit IgG SR: human
Immunogen: synthetic peptide. The epitope recognized by A301-407A maps to a region between residue 550 and 600 of human KN motif and ankyrin repeat domains 2 (SRC-1 interacting protein) using the numbering given in entry NP_056308.2 (GeneID 25959).
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A302-427A
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Poly(A) polymerase gamma (PAP-gamma) is a member of the poly(A) polymerase family which catalyzes template-independent extension of the 3 end of a DNA/RNA strand. This enzyme shares 60 percent identity to the well characterized poly(A) polymerase II (PAPII) at the amino acid level. These two enzymes have similar organization of structural and functional domains. PAP-gamma is exclusively localized in the nucleus and exhibits nonspecific as well as CPSF (cleavage and polyadenylation specificity factor)/AAUAAA-dependent polyadenylation activity. Alternative names for PAP gamma include polynucleotide adenylyltransferase gamma, SRP RNA 3 -adenylating enzyme, neo-poly(A) polymerase, Neo-PAP, PAPOLG, PAP2, and PAPG.

Rabbit IgG SR: human, mouse
Immunogen: synthetic peptide. The epitope recognized by A302-427A maps to a region between residue 686 and 736 of human poly(A) polymerase gamma using the numbering given in entry NP_075045.2 (GeneID 64895).
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A310-513A
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1 each of A301-473A and A301-474A

Rabbit SR: human
Immunogen: synthetic peptide
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A301-472A
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TRAP100/MED24 is a component of the multisubunit mediator complex that functions as an interface between gene-specific transcription factors and the RNA Pol II/general transcription factor machinery. The mediator complex was first identified as a coactivator of the thyroid hormone receptor and has since been observed to function as a coactivator of a variety of transcription factors. TRAP100/MED24 associates with mediator subunit TRAP220. Both are essential to mouse development and play a role in androgen receptor-mediated transcription. Studies in zebrafish have shown that TRAP100/MED24 is also important to retinal development. Alternate names for TRAP100/MED24 include mediator of RNA polymerase II transcription subunit 24, mediator complex 24, thyroid hormone receptor-associated protein complex 100 kDa component, thyroid hormone receptor-associated protein 4, vitamin D3 receptor-interacting protein complex component DRIP100, ARC100, CRSP complex subunit 4, THRAP4, MGC8748, and KIAA0130.

Rabbit IgG SR: human, mouse
Immunogen: synthetic peptide. The epitope recognized by A301-472A maps to a region between residue 939 and 989 of human thyroid hormone receptor-associated protein complex 100 kDa component (mediator complex subunit 24 ) using the numbering given in entry NP_055630.
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A302-632A
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WDR11 is a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. The WDR11 gene is located in the chromosome 10q25-26 region, which is frequently deleted in gliomas and tumors of other tissues, and is disrupted by the t(10,19) translocation rearrangement in glioblastoma cells. The gene location suggests that it is a candidate gene for the tumor suppressor locus. Alternative names for WDR11 include bromodomain and WD repeat-containing 2, BRWD2, and KIAA1351.[taken from NCBI Entrez Gene (GeneID: 55717)]

Rabbit IgG SR: human
Immunogen: synthetic peptide. The epitope recognized by A302-632A maps to a region between residue 1174 and 1224 of human WD repeat domain 11 using the numbering given in entry NP_060587.8 (GeneID 55717).
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A301-529A
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ZNF295 bears 8 C2H2-type zinc fingers and a BTB/POZ (broad-complex, tramtrack, bric a brac/ Pox-virus and zinc finger) domain indicating a function in transcriptional regulation. ZNF295 has been shown to function as a transcriptional repressor and associates with ZFP161, a zinc-finger protein also know to function as a repressor of transcription. Alternate name for ZNF295 include zinc-finger protein 295, zinc finger and BTB domain-containing protein 21, ZBTB21, and KIAA1227.

Rabbit IgG SR: human
Immunogen: synthetic peptide. The epitope recognized by A301-529A maps to a region between residue 1016 and 1066 of human zinc finger protein 295 using the numbering given in entry NP_065778.3 (GeneID 49854).
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A300-747A
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ZCH13 is an uncharacterized zinc-finger CCCH-type containing protein. Zinc-finger modules have been shown to be involved in nucleic acid binding, protein-protein interactions, and binding of small ligands. Alternate names for ZCH13 include zinc finger CCCH-type containing 13, KIAA0853, and FLJ35669.

Rabbit IgG SR: human, mouse
Immunogen: synthetic peptide. The epitope recognized by A300-747A maps to a region between residue 15 and 75 of human Zinc Finger CCCH-type Containing 13 using the numbering given in entry NP_055885.2 (GeneID 23091).
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A10-113A
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Sheep IgG SR: bovine
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A80-109A
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Format - Whole IgG

Rabbit IgG SR: human
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A90-616AP
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Whole IgG

Goat IgG SR: mouse
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A300-247A
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p53 is a tumor suppressor protein that is mutated or inactivated in over 50 percent of human cancers. Loss of function defects in p53 are the cause of the autosomal dominant familial cancer syndrome, Li-Fraumeni syndrome (LFS) that is characterized by the development of a diverse set of malignancies at very early ages. At the cellular level p53 is involved in the negative regulation of cell the cycle via its transactivational control of genes required for cell cycle progression. Depending on the physiological circumstance, p53 can promote growth arrest or apoptosis. Alternate names for p53 include cellular tumor antigen p53, tumor suppressor p53, phosphoprotein p53, antigen NY-CO-13, TP53, TRP53, and Li-Fraumeni syndrome.

Rabbit IgG SR: human
Immunogen: synthetic peptide. The epitope recognized by A300-247A maps to a region between residues 50 and 100 of human tumor protein p53 using the numbering given in SwissProt entry P04637 (GeneID 7157).
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A300-248A
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p53 is a tumor suppressor protein that is mutated or inactivated in over 50 percent of human cancers. Loss of function defects in p53 are the cause of the autosomal dominant familial cancer syndrome, Li-Fraumeni syndrome (LFS) that is characterized by the development of a diverse set of malignancies at very early ages. At the cellular level p53 is involved in the negative regulation of cell the cycle via its transactivational control of genes required for cell cycle progression. Depending on the physiological circumstance, p53 can promote growth arrest or apoptosis. Alternate names for p53 include cellular tumor antigen p53, tumor suppressor p53, phosphoprotein p53, antigen NY-CO-13, TP53, TRP53, and Li-Fraumeni syndrome.

Rabbit IgG SR: human
Immunogen: synthetic peptide. The epitope recognized by A300-248A maps to a region between residues 325 and 375 of human tumor protein p53 using the numbering given in SwissProt entry P04637 (GeneID 7157).
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A300-249A
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p53 is a tumor suppressor protein that is mutated or inactivated in over 50 percent of human cancers. Loss of function defects in p53 are the cause of the autosomal dominant familial cancer syndrome, Li-Fraumeni syndrome (LFS) that is characterized by the development of a diverse set of malignancies at very early ages. At the cellular level p53 is involved in the negative regulation of cell the cycle via its transactivational control of genes required for cell cycle progression. Depending on the physiological circumstance, p53 can promote growth arrest or apoptosis. Alternate names for p53 include cellular tumor antigen p53, tumor suppressor p53, phosphoprotein p53, antigen NY-CO-13, TP53, TRP53, and Li-Fraumeni syndrome.

Rabbit IgG SR: human
Immunogen: synthetic peptide. The epitope recognized by A300-249A maps to a region between residues 375 and the C-terminus (residue 393) of human tumor protein p53 using the numbering given in SwissProt entry P04637 (GeneID 7157).
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A310-068A
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Antibodies were affinity purified using epitopes specific to p53 immobilized on solid support.

Rabbit IgG SR: human
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IHC-00010
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p53 is a tumor suppressor protein that is mutated or inactivated in over 50 percent of human cancers. Loss of function defects in p53 are the cause of the autosomal dominant familial cancer syndrome, Li-Fraumeni syndrome (LFS) that is characterized by the development of a diverse set of malignancies at very early ages. At the cellular level p53 is involved in the negative regulation of cell the cycle via its transactivational control of genes required for cell cycle progression. Depending on the physiological circumstance, p53 can promote growth arrest or apoptosis. Alternate names for p53 include cellular tumor antigen p53, tumor suppressor p53, phosphoprotein p53, antigen NY-CO-13, TP53, TRP53, and Li-Fraumeni syndrome.

Rabbit IgG SR: human
Immunogen: synthetic peptide. The epitope recognized by IHC-00010P maps to a region between residue 50 and 100 of human tumor protein p53 using the numbering given in entry NP 000537.2 (GeneID 7157).
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A300-387A
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The epidermal growth factor receptor (EGFR) is a membrane spanning tyrosine kinase receptor for epidermal growth factor (EGF) and other ligands of the EGF family such as TGF-alpha, amphiregulin, betacellulin, epiregulin and heparin-binding EGF-like growth factor. Upon ligand binding, the EGFR homodimerizes or heterodimerizes with other ErbB receptor family members and tranduces a downstream signal via the ras-raf-mitogen activated protein kinase pathway or the phosphatidylinositol 3-kinase (PI3K)/Akt pathway. Signals from the EGFR function to influence cell proliferation, differentiation, and development. Alternate names for EGFR include receptor tyrosine-protein kinase ErbB-1, ERBB1, ERBB, and mENA.

Rabbit IgG SR: human
Immunogen: synthetic peptide. The epitope recognized by A300-387A maps to a region between residues 1100 and 1150 of human Epidermal Growth Factor Receptor using the numbering given in Swiss-Prot entry P00533 (GeneID 1956).
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A300-388A
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The epidermal growth factor receptor (EGFR) is a membrane spanning tyrosine kinase receptor for epidermal growth factor (EGF) and other ligands of the EGF family such as TGF-alpha, amphiregulin, betacellulin, epiregulin and heparin-binding EGF-like growth factor. Upon ligand binding, the EGFR homodimerizes or heterodimerizes with other ErbB receptor family members and tranduces a downstream signal via the ras-raf-mitogen activated protein kinase pathway or the phosphatidylinositol 3-kinase (PI3K)/Akt pathway. Signals from the EGFR function to influence cell proliferation, differentiation, and development. Alternate names for EGFR include receptor tyrosine-protein kinase ErbB-1, ERBB1, ERBB, and mENA.

Rabbit IgG SR: human
Immunogen: synthetic peptide. The epitope recognized by A300-388A maps to a region between residue 1150 and the C-terminus (residue 1210) of human Epidermal Growth Factor Receptor using the numbering given in Swiss-Prot entry P00533 (GeneID 1956).
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A310-105A
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Antibodies were affinity purified using epitopes specific to EGFR immobilized on solid support.

Rabbit IgG SR: human
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IHC-00005
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The epidermal growth factor receptor (EGFR) is a membrane spanning tyrosine kinase receptor for epidermal growth factor (EGF) and other ligands of the EGF family such as TGF-alpha, amphiregulin, betacellulin, epiregulin and heparin-binding EGF-like growth factor. Upon ligand binding, the EGFR homodimerizes or heterodimerizes with other ErbB receptor family members and tranduces a downstream signal via the ras-raf-mitogen activated protein kinase pathway or the phosphatidylinositol 3-kinase (PI3K)/Akt pathway. Signals from the EGFR function to influence cell proliferation, differentiation, and development. Alternate names for EGFR include receptor tyrosine-protein kinase ErbB-1, ERBB1, ERBB, and mENA.

Rabbit IgG SR: human, mouse
Immunogen: synthetic peptide. The epitope recognized by IHC-00005 maps to a region between residue 1150 and the C-terminus (residue 1210) of human Epidermal Growth Factor Receptor using the numbering given in SwissProt entry P00533 (GeneID 1956).
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A303-252A
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c-Kit is the receptor for stem cell factor (mast cell growth factor). It is a transmembrane receptor with tyrosine-protein kinase activity. Binding of the ligands leads to the autophosphorylation of the c-Kit receptor and its association with substrates such as phosphatidylinositol 3-kinase (Pi3K). Alternative names for c-Kit include, v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog, mast/stem cell growth factor receptor, proto-oncogene c-Kit, CD_antigen 117, CD117, KIT, PBT, and SCFR. [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/ P10721]

Rabbit IgG SR: human
Immunogen: synthetic peptide. The epitope recognized by A303-252A maps to a region between residue 925 and 976 of c-Kit using the numbering given in entry NP_000213.1 (GeneID 3815).
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A302-065A
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AKT1 is a serine-threonine kinase that functions downstream of PI-3 kinase and is known to phosphorylate several proteins. AKT1 is also known as RAC-PK-alpha, and protein kinase B (PKB). AKT1 mediates the effects of several growth factors such as insulin, IGF-1, EGF, and PDGF to control cell survival and apoptosis. There are numerous substrates of AKT1, some of which are: GSK3-alpha and beta, mTOR, TSC2, Bad, c-Raf, and caspase 9.

Rabbit IgG SR: human
Immunogen: synthetic peptide. The epitope recognized by A302-065A maps to a region between residue 25 and 75 of human v-akt murine thymoma viral oncogene homolog 1 using the numbering given in entry NP_005154.1 (GeneID 207).
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IHC-00513
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AKT1 is a serine-threonine kinase that functions downstream of PI-3 kinase and is known to phosphorylate several proteins. AKT1 is also known as RAC-PK-alpha, and protein kinase B (PKB). AKT1 mediates the effects of several growth factors such as insulin, IGF-1, EGF, and PDGF to control cell survival and apoptosis. There are numerous substrates of AKT1, some of which are: GSK3-alpha and beta, mTOR, TSC2, Bad, c-Raf, and caspase 9.

Rabbit IgG SR: human
Immunogen: synthetic peptide. The epitope recognized by IHC-00513 maps to a region between residue 25 and 75 of human v-akt murine thymoma viral oncogene homolog 1 using the numbering given in entry NP_005154.1 (GeneID 207).
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A303-965A
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The androgen receptor (AR) functions as a steroid-hormone activated transcription factor. Upon binding the hormone ligand, the receptor dissociates from accessory proteins, translocates into the nucleus, dimerizes, and then stimulates transcription of androgen responsive genes [taken from NCBI Entrez Gene (Gene ID: 367)].

Rabbit IgG SR: human
Immunogen: synthetic peptide. The epitope recognized by A303-965A maps to a region between residue 1 to 50 of human Androgen Receptor using the numbering given in entry NP_000035.2 (GeneID 367).
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A303-966A
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The androgen receptor (AR) functions as a steroid-hormone activated transcription factor. Upon binding the hormone ligand, the receptor dissociates from accessory proteins, translocates into the nucleus, dimerizes, and then stimulates transcription of androgen responsive genes [taken from NCBI Entrez Gene (Gene ID: 367)].

Rabbit IgG SR: human
Immunogen: synthetic peptide. The epitope recognized by A303-966A maps to a region between residue 870 to 920 of human Androgen Receptor using the numbering given in entry NP_000035.2 (GeneID 367).
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A311-436A
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1 each of A303-965A and A303-966A

Rabbit IgG SR: human
Immunogen: synthetic peptide. Antibodies were affinity purified using epitopes specific to Androgen Receptor immobilized on solid support.
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A302-010A
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Beta-catenin plays an integral role in the Wnt signaling pathway and is critical to morphogenic signaling and body axis specification. Beta-catenin exists in complexes with cadherins, transmembrane proteins that mediate cell adhesion. When Wnt-signaling proteins bind their receptors, beta-catenin is stabilized and accumulates in the cell. Translocation of stabilized beta-catenin allows its association with transcription factors and the activation of specific gene expression. Alternative names for beta-catenin include catenin beta-1, CTNNB1, and CTNNB.

Rabbit IgG SR: human, mouse
Immunogen: synthetic peptide. The epitope recognized by A302-010A maps to a region between residue 25 and 75 of human beta-catenin using the numbering given in entry NP_001895.1 (GeneID 1499).
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A302-011A
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Beta-catenin plays an integral role in the Wnt signaling pathway and is critical to morphogenic signaling and body axis specification. Beta-catenin exists in complexes with cadherins, transmembrane proteins that mediate cell adhesion. When Wnt-signaling proteins bind their receptors, beta-catenin is stabilized and accumulates in the cell. Translocation of stabilized beta-catenin allows its association with transcription factors and the activation of specific gene expression. Alternative names for beta-catenin include catenin beta-1, CTNNB1, and CTNNB.

Rabbit IgG SR: human, mouse
Immunogen: synthetic peptide. The epitope recognized by A302-011A maps to a region between residue 710 and 760 of human beta-catenin using the numbering given in entry NP_001895.1 (GeneID 1499).
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A302-012A
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Beta-catenin plays an integral role in the Wnt signaling pathway and is critical to morphogenic signaling and body axis specification. Beta-catenin exists in complexes with cadherins, transmembrane proteins that mediate cell adhesion. When Wnt-signaling proteins bind their receptors, beta-catenin is stabilized and accumulates in the cell. Translocation of stabilized beta-catenin allows its association with transcription factors and the activation of specific gene expression. Alternative names for beta-catenin include catenin beta-1, CTNNB1, and CTNNB.

Rabbit IgG SR: human, mouse
Immunogen: synthetic peptide. The epitope recognized by A302-012A maps to a region between residue 760 and 781 of human beta-catenin using the numbering given in entry NP_001895.1 (GeneID 1499).
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A310-710A
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1 each of A302-010A, A302-011A and A302-012A

Rabbit IgG SR: human, mouse
Immunogen: synthetic peptide
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IHC-00584
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Involved in the regulation of cell adhesion. The majority of beta-catenin is localized to the cell membrane and is part of E-cadherin/catenin adhesion complexes which are proposed to couple cadherins to the actin cytoskeleton.

Rabbit IgG SR: human, mouse
Immunogen: synthetic peptide. The epitope recognized by IHC-00584 maps to a region between residue 760 and 781 of human beta-catenin using the numbering given in entry NP_001895.1 (GeneID 1499).
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A302-432A
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Retinoblastoma 1 (Rb1) is a negative regulator of the cell cycle and was the first tumor suppressor gene found. Rb1 has also been found to stabilize constitutive heterochromatin to maintain the overall chromatin structure. The active, hypophosphorylated form of the protein binds transcription factor E2F1. Defects in this gene are a cause of childhood cancer retinoblastoma (RB), bladder cancer, and osteogenic sarcoma. Alternative names for Rb1 include retinoblastoma susceptibility protein, retinoblastoma-associated protein, pRb, RB, RB1, pp110, and p105-Rb.

Rabbit IgG SR: human
Immunogen: synthetic peptide. The epitope recognized by A302-432A maps to a region between residue 550 and 600 of human retinoblastoma 1 using the numbering given in entry NP_000312.2 (GeneID 5925).
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A302-433A
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Retinoblastoma 1 (Rb1) is a negative regulator of the cell cycle and was the first tumor suppressor gene found. Rb1 has also been found to stabilize constitutive heterochromatin to maintain the overall chromatin structure. The active, hypophosphorylated form of the protein binds transcription factor E2F1. Defects in this gene are a cause of childhood cancer retinoblastoma (RB), bladder cancer, and osteogenic sarcoma. Alternative names for Rb1 include retinoblastoma susceptibility protein, retinoblastoma-associated protein, pRb, RB, RB1, pp110, and p105-Rb.

Rabbit IgG SR: human
Immunogen: synthetic peptide. The epitope recognized by A302-433A maps to a region between residue 878 and 928 of human retinoblastoma 1 using the numbering given in entry NP_000312.2 (GeneID 5925).
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A310-881A
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1 each of A302-432A and A302-433A

Rabbit IgG SR: human
Immunogen: synthetic peptide
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A300-024A
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PTEN (phosphatase and tensin homolog) is a phosphatidylinositol-3,4,5-triphosphate 3-phosphatase that has been identified as a tumor suppressor. PTEN is a dual specificity tyrosine and serine/threonine phosphatase that preferentially dephosphorylates phosphoinositide substrates and negatively regulates the AKT/PKB signaling pathway. Through its action, PTEN has been shown to modulate cell cycle progression, cell survival, cell migration, cell adhesion, and insulin signaling. PTEN is also known as mutated in multiple advanced cancers 1, MMAC1, TEP1, BZS, MHAM, and MGC11227.

Rabbit IgG SR: human
Immunogen: synthetic peptide. The epitope recognized by A300-024A maps to a region between residue 350 and the C-terminus (residue 403) of human phosphatase and tensin homolog using the numbering given in entry NP_000305.2 (GeneID 5728).
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A300-699A
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PTEN (phosphatase and tensin homolog) is a phosphatidylinositol-3,4,5-triphosphate 3-phosphatase that has been identified as a tumor suppressor. PTEN is a dual specificity tyrosine and serine/threonine phosphatase that preferentially dephosphorylates phosphoinositide substrates and negatively regulates the AKT/PKB signaling pathway. Through its action, PTEN has been shown to modulate cell cycle progression, cell survival, cell migration, cell adhesion, and insulin signaling. PTEN is also known as mutated in multiple advanced cancers 1, MMAC1, TEP1, BZS, MHAM, and MGC11227.

Rabbit IgG SR: human
Immunogen: synthetic peptide. The epitope recognized by A300-699A maps to a region between residue 1 and 50 of human phosphatase and tensin homolog using the numbering given in entry NP_000305.2 (GeneID 5728).
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A300-700A
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PTEN (phosphatase and tensin homolog) is a phosphatidylinositol-3,4,5-triphosphate 3-phosphatase that has been identified as a tumor suppressor. PTEN is a dual specificity tyrosine and serine/threonine phosphatase that preferentially dephosphorylates phosphoinositide substrates and negatively regulates the AKT/PKB signaling pathway. Through its action, PTEN has been shown to modulate cell cycle progression, cell survival, cell migration, cell adhesion, and insulin signaling. PTEN is also known as mutated in multiple advanced cancers 1, MMAC1, TEP1, BZS, MHAM, and MGC11227.

Rabbit IgG SR: human
Immunogen: synthetic peptide. The epitope recognized by A300-700A maps to a region between residue 325 and 375 of human phosphatase and tensin homolog using the numbering given in entry NP_000305.2 (GeneID 5728).
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A300-701A
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PTEN (phosphatase and tensin homolog) is a phosphatidylinositol-3,4,5-triphosphate 3-phosphatase that has been identified as a tumor suppressor. PTEN is a dual specificity tyrosine and serine/threonine phosphatase that preferentially dephosphorylates phosphoinositide substrates and negatively regulates the AKT/PKB signaling pathway. Through its action, PTEN has been shown to modulate cell cycle progression, cell survival, cell migration, cell adhesion, and insulin signaling. PTEN is also known as mutated in multiple advanced cancers 1, MMAC1, TEP1, BZS, MHAM, and MGC11227.

Rabbit IgG SR: human, mouse
Immunogen: synthetic peptide. The epitope recognized by A300-701A maps to a region between residue 350 and the C-terminus (residue 403) of human phosphatase and tensin homolog using the numbering given in entry NP_000305.2 (GeneID 5728).
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A310-209A
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Antibodies were affinity purified using epitopes specific to PTEN immobilized on solid support.

Rabbit IgG SR: human, mouse
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IHC-00358
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PTEN (phosphatase and tensin homolog) is a phosphatidylinositol-3,4,5-triphosphate 3-phosphatase that has been identified as a tumor suppressor. PTEN is a dual specificity tyrosine and serine/threonine phosphatase that preferentially dephosphorylates phosphoinositide substrates and negatively regulates the AKT/PKB signaling pathway. Through its action, PTEN has been shown to modulate cell cycle progression, cell survival, cell migration, cell adhesion, and insulin signaling. PTEN is also known as mutated in multiple advanced cancers 1, MMAC1, TEP1, BZS, MHAM, and MGC11227.

Rabbit IgG SR: human
Immunogen: synthetic peptide. The epitope recognized by IHC-00358 maps to a region between residue 350 and the C-terminus (residue 403) of human phosphatase and tensin homolog using the numbering given in entry NP_000305.2 (GeneID 5728).
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A300-495A
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Estrogen receptor-related alpha (ERRA) is a nuclear orphan receptor structurally related to the estrogen receptor (ER). ERRA and ERalpha share approximately 68 percent sequence identity in their DNA binding domain and 33 percent in their ligand-binding domain. There is evidence that ERRA and ERalpha bind similar promoter elements and that ERRA can activate ERalpha targets in the absence of estrogen. Additional names for ERRA include estrogen receptor like 1, nuclear receptor subfamily 3 group B member 1, ERRalpha, ESRRA, ERR1, ESRL1, and NR3B1.

Rabbit IgG SR: human
Immunogen: synthetic peptide. The epitope recognized by A300-495A maps to a region between residues 1 and 50 of human Estrogen Receptor Alpha using the numbering given in SwissProt entry P03372 (GeneID 2099).
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A300-496A
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Estrogen receptor-related alpha (ERRA) is a nuclear orphan receptor structurally related to the estrogen receptor (ER). ERRA and ERalpha share approximately 68 percent sequence identity in their DNA binding domain and 33 percent in their ligand-binding domain. There is evidence that ERRA and ERalpha bind similar promoter elements and that ERRA can activate ERalpha targets in the absence of estrogen. Additional names for ERRA include estrogen receptor like 1, nuclear receptor subfamily 3 group B member 1, ERRalpha, ESRRA, ERR1, ESRL1, and NR3B1.

Rabbit IgG SR: human
Immunogen: synthetic peptide. The epitope recognized by A300-496A maps to a region between residues 100 and 150 of human Estrogen Receptor Alpha using the numbering given in SwissProt entry P03372 (GeneID 2099).
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A300-497A
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Estrogen receptor-related alpha (ERRA) is a nuclear orphan receptor structurally related to the estrogen receptor (ER). ERRA and ERalpha share approximately 68 percent sequence identity in their DNA binding domain and 33 percent in their ligand-binding domain. There is evidence that ERRA and ERalpha bind similar promoter elements and that ERRA can activate ERalpha targets in the absence of estrogen. Additional names for ERRA include estrogen receptor like 1, nuclear receptor subfamily 3 group B member 1, ERRalpha, ESRRA, ERR1, ESRL1, and NR3B1.

Rabbit IgG SR: human
Immunogen: synthetic peptide. The epitope recognized by A300-497A maps to a region between residues 525 and 575 of human Estrogen Receptor Alpha using the numbering given in SwissProt entry P03372 (GeneID 2099).
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A300-498A
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Estrogen receptor-related alpha (ERRA) is a nuclear orphan receptor structurally related to the estrogen receptor (ER). ERRA and ERalpha share approximately 68 percent sequence identity in their DNA binding domain and 33 percent in their ligand-binding domain. There is evidence that ERRA and ERalpha bind similar promoter elements and that ERRA can activate ERalpha targets in the absence of estrogen. Additional names for ERRA include estrogen receptor like 1, nuclear receptor subfamily 3 group B member 1, ERRalpha, ESRRA, ERR1, ESRL1, and NR3B1.

Rabbit IgG SR: human
Immunogen: synthetic peptide. The epitope recognized by A300-498A maps to a region between residue 550 and the C-terminus (residue 595) of human Estrogen Receptor Alpha using the numbering given in SwissProt entry P03372 (GeneID 2099).
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A300-598A
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Estrogen receptor-related alpha (ERRA) is a nuclear orphan receptor structurally related to the estrogen receptor (ER). ERRA and ERalpha share approximately 68 percent sequence identity in their DNA binding domain and 33 percent in their ligand-binding domain. There is evidence that ERRA and ERalpha bind similar promoter elements and that ERRA can activate ERalpha targets in the absence of estrogen. Additional names for ERRA include estrogen receptor like 1, nuclear receptor subfamily 3 group B member 1, ERRalpha, ESRRA, ERR1, ESRL1, and NR3B1.

Rabbit IgG SR: human
Immunogen: synthetic phospho-peptide. Immunogen for A300-598A was a phosphorylated synthetic peptide, which represented a portion of human Estrogen Receptor Alpha (GeneID 2099) around serine 305 according to the numbering given in entry NP_000116.2.
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A310-143A
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Antibodies were affinity purified using epitopes specific to Estrogen Receptor Alpha immobilized on solid support.

Rabbit IgG SR: human
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IHC-00006
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The estrogen receptor (ER) is the steroid-hormone nuclear receptor that binds estrogen and functions to activate genes involved in a variety of biological processes. Two forms of the ER, ER alpha and ER beta, are encoded by independent genes, and each plays different roles in gene regulation. Additional variants of ER beta have also been reported, these include ERb2, ERb3, ERb4, and ERb5. All forms of the ER have the ability to heterodimerize with each other. Differences in localization and concentrations as well as heterodimerization among the variants may serve to achieve distinct cell and tissue responses. ER alpha generally functions as an activator of transcription while ER beta functions as a repressor. Alternate names for ER alpha include estradiol receptor, ESR1, ER, Era, NR3A1, and DKFZp686N23123.

Rabbit IgG SR: human
Immunogen: synthetic peptide. The epitope recognized by IHC-00006 maps to a region between residue 550 and the C-terminus (residue 595) of human Estrogen Receptor Alpha using the numbering given in SwissProt entry P03372 (GeneID 2099).
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A301-823A
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RelA, also known as p52, is one of five monomeric subunits that are part of the Rel family of proteins that dimerize to form the NF-kappa B (nuclear factor that binds the kappa immunoglobulin light chain gene enhancer) transcription factor. Members of the Rel family of proteins include NF-kappa B1/p50, NF-kappa B2/p52, RelA/p65, c-Rel, and RelB. Each Rel member bears a characteristic 300 amino acid N-terminal Rel homology domain (RHD) that functions to mediate DNA binding, dimerization, nuclear localization, and inhibitor association.

Rabbit IgG SR: human
Immunogen: synthetic peptide. The epitope recognized by A301-823A maps to a region between residue 1 and 50 of human reticuloendotheliosis viral oncogene homolog A using the numbering given in entry NP_068810.2 (GeneID 5970).
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A302-062A
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The epitope recognized by A302-062A maps to a region of human v-rel reticuloendotheliosis viral oncogene homolog A surrounding serine 536 when serine 536 is phosphorylated using the numbering given in entry NP_068810.2 (GeneID 5970).

Rabbit IgG SR: human
Immunogen: synthetic phospho-peptide. The epitope recognized by A302-062A maps to a region of human v-rel reticuloendotheliosis viral oncogene homolog A surrounding serine 536 when serine 536 is phosphorylated using the numbering given in entry NP_068810.2 (GeneID 5
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A302-063A
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The epitope recognized by A302-063A maps to a region of human v-rel reticuloendotheliosis viral oncogene homolog A surrounding serine 529 when serine 529 is phosphorylated using the numbering given in entry NP_068810.2 (GeneID 5970).

Rabbit IgG SR: human
Immunogen: synthetic phospho-peptide. The epitope recognized by A302-063A maps to a region of human v-rel reticuloendotheliosis viral oncogene homolog A surrounding serine 529 when serine 529 is phosphorylated using the numbering given in entry NP_068810.2 (GeneID 5
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A302-064A
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The epitope recognized by A302-064A maps to a region of human v-rel reticuloendotheliosis viral oncogene homolog A surrounding serine 468 when serine 468 is phosphorylated using the numbering given in entry NP_068810.2 (GeneID 5970).

Rabbit IgG SR: human
Immunogen: synthetic phospho-peptide. The epitope recognized by A302-064A maps to a region of human v-rel reticuloendotheliosis viral oncogene homolog A surrounding serine 468 when serine 468 is phosphorylated using the numbering given in entry NP_068810.2 (GeneID 5
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A303-945A
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RelA, is one of five monomeric subunits that are part of the Rel family of proteins that dimerize to form the NF-kappa B (nuclear factor that binds the kappa immunoglobulin light chain gene enhancer) transcription factor. Members of the Rel family of proteins include NF-kappa B1/p50, NF-kappa B2/p52, RelA/p65, c-Rel, and RelB. Each Rel member bears a characteristic 300 amino acid N-terminal Rel homology domain (RHD) that functions to mediate DNA binding, dimerization, nuclear localization, and inhibitor association.

Goat IgG SR: human, mouse
Immunogen: Synthetic peptide. The epitope recognized by A303-945A maps to a region between residue 501 to 551 of human Reticuloendotheliosis Viral Oncogene Homolog A using the numbering given in entry NP_068810.2 (GeneID 5970).
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A310-650A
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1 each of A301-823A and A301-824A

Rabbit IgG SR: human, mouse
Immunogen: synthetic peptide
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IHC-00520
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RelA, also known as p52, is one of five monomeric subunits that are part of the Rel family of proteins that dimerize to form the NF-kappa B (nuclear factor that binds the kappa immunoglobulin light chain gene enhancer) transcription factor. Members of the Rel family of proteins include NF-kappa B1/p50, NF-kappa B2/p52, RelA/p65, c-Rel, and RelB. Each Rel member bears a characteristic 300 amino acid N-terminal Rel homology domain (RHD) that functions to mediate DNA binding, dimerization, nuclear localization, and inhibitor association.

Rabbit SR: human
Immunogen: synthetic peptide. The epitope recognized by IHC-00520 maps to a region between residue 501 and 551 of human reticuloendotheliosis viral oncogene homolog A using the numbering given in entry NP_068810.2 (GeneID 5970).
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IHC-00524
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RelA, also known as p52, is one of five monomeric subunits that are part of the Rel family of proteins that dimerize to form the NF-kappa B (nuclear factor that binds the kappa immunoglobulin light chain gene enhancer) transcription factor. Members of the Rel family of proteins include NF-kappa B1/p50, NF-kappa B2/p52, RelA/p65, c-Rel, and RelB. Each Rel member bears a characteristic 300 amino acid N-terminal Rel homology domain (RHD) that functions to mediate DNA binding, dimerization, nuclear localization, and inhibitor association.

Rabbit SR: human
Immunogen: synthetic peptide. The epitope recognized by IHC-00524 maps to a region of human v-rel reticuloendotheliosis viral oncogene homolog A surrounding serine 536 when serine 536 is phosphorylated using the numbering given in entry NP_068810.2 (GeneID 5970).
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IHC-00525
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RelA, also known as p52, is one of five monomeric subunits that are part of the Rel family of proteins that dimerize to form the NF-kappa B (nuclear factor that binds the kappa immunoglobulin light chain gene enhancer) transcription factor. Members of the Rel family of proteins include NF-kappa B1/p50, NF-kappa B2/p52, RelA/p65, c-Rel, and RelB. Each Rel member bears a characteristic 300 amino acid N-terminal Rel homology domain (RHD) that functions to mediate DNA binding, dimerization, nuclear localization, and inhibitor association.

Rabbit SR: human
Immunogen: synthetic peptide. The epitope recognized by IHC-00525 maps to a region of human v-rel reticuloendotheliosis viral oncogene homolog A surrounding serine 468 when serine 468 is phosphorylated using the numbering given in entry NP_068810.2 (GeneID 5970).
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A300-621A
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ErbB2 is a member of the receptor tyrosine kinase family of proteins. The four members of this family are ErbB1 (Epidermal growth factor receptor, EGFR/HER1), ErbB2 (HER2/Neu), ErbB3 (HER3), and ErbB4 (HER4). The ErbB receptor members are single-pass transmembrane proteins with an extracellular ligand-binding domain and a cytoplasmic tyrosine-kinase domain. The epidermal growth factor (EGF) and its related proteins serve as the ligands for the ErbB receptors. Upon binding, the receptors heterodimerize, autophosphorylate and make contact with adapter molecules to transmit cellular signals involved in cell proliferation, survival, and differentiation. The ErbB2 receptor is the only member that does not interact with a ligand, but instead functions as a heterodimeric partner to coordinate signals from other ligand bound ErbB receptors. Amplification and/or overexpression of ErbB2 have been reported in many cancers. Alternate names for ErbB2 include receptor tyrosine-protein kinase erbB-2. p185erbB2, C-erbB-2, Neu proto-oncogene, tyrosine kinase-type cell surface receptor HER2, TKR1, c-erb B2, MLN 19, ERBB2, HER2, NEU, and NGL.

Rabbit IgG SR: human
Immunogen: synthetic peptide. The epitope recognized by A300-621A maps to a region between residues 975 and 1025 of human v-erb-b2 erythroblastic leukemia viral oncogene homolog 2 using the numbering given in entry NP_004439.2 (GeneID 2064).
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A300-622A
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ErbB2 is a member of the receptor tyrosine kinase family of proteins. The four members of this family are ErbB1 (Epidermal growth factor receptor, EGFR/HER1), ErbB2 (HER2/Neu), ErbB3 (HER3), and ErbB4 (HER4). The ErbB receptor members are single-pass transmembrane proteins with an extracellular ligand-binding domain and a cytoplasmic tyrosine-kinase domain. The epidermal growth factor (EGF) and its related proteins serve as the ligands for the ErbB receptors. Upon binding, the receptors heterodimerize, autophosphorylate and make contact with adapter molecules to transmit cellular signals involved in cell proliferation, survival, and differentiation. The ErbB2 receptor is the only member that does not interact with a ligand, but instead functions as a heterodimeric partner to coordinate signals from other ligand bound ErbB receptors. Amplification and/or overexpression of ErbB2 have been reported in many cancers. Alternate names for ErbB2 include receptor tyrosine-protein kinase erbB-2. p185erbB2, C-erbB-2, Neu proto-oncogene, tyrosine kinase-type cell surface receptor HER2, TKR1, c-erb B2, MLN 19, ERBB2, HER2, NEU, and NGL.

Rabbit IgG SR: human
Immunogen: synthetic peptide. The epitope recognized by A300-622A maps to a region between residues 1200 and 1250 of human v-erb-b2 erythroblastic leukemia viral oncogene homolog 2 using the numbering given in entry NP_004439.2 (GeneID 2064).
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A300-623A
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ErbB2 is a member of the receptor tyrosine kinase family of proteins. The four members of this family are ErbB1 (Epidermal growth factor receptor, EGFR/HER1), ErbB2 (HER2/Neu), ErbB3 (HER3), and ErbB4 (HER4). The ErbB receptor members are single-pass transmembrane proteins with an extracellular ligand-binding domain and a cytoplasmic tyrosine-kinase domain. The epidermal growth factor (EGF) and its related proteins serve as the ligands for the ErbB receptors. Upon binding, the receptors heterodimerize, autophosphorylate and make contact with adapter molecules to transmit cellular signals involved in cell proliferation, survival, and differentiation. The ErbB2 receptor is the only member that does not interact with a ligand, but instead functions as a heterodimeric partner to coordinate signals from other ligand bound ErbB receptors. Amplification and/or overexpression of ErbB2 have been reported in many cancers. Alternate names for ErbB2 include receptor tyrosine-protein kinase erbB-2. p185erbB2, C-erbB-2, Neu proto-oncogene, tyrosine kinase-type cell surface receptor HER2, TKR1, c-erb B2, MLN 19, ERBB2, HER2, NEU, and NGL.

Rabbit IgG SR: human
Immunogen: synthetic peptide. The epitope recognized by A300-623A maps to a region between residue 1200 and the C-terminus (residue 1255) of human v-erb-b2 erythroblastic leukemia viral oncogene homolog 2 using the numbering given in entry NP_004439.2 (GeneID 2064).
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A310-183A
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Antibody was affinity purified using an epitope specific to ErbB2 immobilized on solid support.

Rabbit IgG SR: human
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IHC-00032
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ErbB2 is a member of the receptor tyrosine kinase family of proteins. The four members of this family are ErbB1 (Epidermal growth factor receptor, EGFR/HER1), ErbB2 (HER2/Neu), ErbB3 (HER3), and ErbB4 (HER4). The ErbB receptor members are single-pass transmembrane proteins with an extracellular ligand-binding domain and a cytoplasmic tyrosine-kinase domain. The epidermal growth factor (EGF) and its related proteins serve as the ligands for the ErbB receptors. Upon binding, the receptors heterodimerize, autophosphorylate and make contact with adapter molecules to transmit cellular signals involved in cell proliferation, survival, and differentiation. The ErbB2 receptor is the only member that does not interact with a ligand, but instead functions as a heterodimeric partner to coordinate signals from other ligand bound ErbB receptors. Amplification and/or overexpression of ErbB2 have been reported in many cancers. Alternate names for ErbB2 include receptor tyrosine-protein kinase erbB-2. p185erbB2, C-erbB-2, Neu proto-oncogene, tyrosine kinase-type cell surface receptor HER2, TKR1, c-erb B2, MLN 19, ERBB2, HER2, NEU, and NGL.

Rabbit IgG SR: human
Immunogen: synthetic peptide. The epitope recognized by IHC-00032 maps to a region between residue 1200 and the C-terminus (residue 1255) of human v-erb-b2 erythroblastic leukemia viral oncogene homolog 2 using the numbering given in entry NP_004439.2 (GeneID 2064)
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A301-519A
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RAF1 is a mitogen activated kinase kinase kinase (MAPKKK). In response to extracellular signals, RAF1 phosphorylates the MEK1 and MEK2 MAP kinase kinases. MEK1 and MEK2 subsequently phosphorylate and activate the ERK1 and ERK2 MAP kinases to exert pleiotropic effects on cellular functions such as growth, division, differentiation, motility, and apoptosis. RAF1 associates with the Ras family of membrane GTPases and functions downstream of Ras activity. Alternate names for RAF1 include RAF proto-oncogene serine/threonine-protein kinase, v-raf-1 murine leukemia viral oncogene homolog 1, Raf-1, C-RAF, and cRaf.

Rabbit IgG SR: human, mouse
Immunogen: synthetic peptide. The epitope recognized by A301-519A maps to a region between residue 598 and 648 of human v-raf-1 murine leukemia viral oncogene homolog 1 using the numbering given in entry NP_002871.1 (GeneID 5894).
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A300-707A
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p38 MAPK is a member of the MAP (mitogen-activated protein) kinase family that is involved in cellular signaling for a wide variety of activities which includes proliferation, differentiation, and transcriptional regulation. p38 MAPK is responsive to growth factors as well as a variety of cellular stress signals such as UV light, inflammatory cytokines, and osmotic shock. Substrates of P38 MAPK include ATF2, MEF2C, MAX, CDC25B and p53. p38 MAPK is activated by MAP kinase kinases such as MAP2K3, MAP2K6, and MAP2K4. Alternate names for p38 MAPK include p38 Mitogen Activated Protein Kinase, MXI2, MAX-interacting protein 2, CSBP,CSBP1, CSBP2, CSPB1, Csaids (cytokine suppressive anti-inflammatory drug) Binding Protein, SAPK2A, stress-activated protein kinase 2A, p38, p38 Alpha, MAPK14, Mitogen Activated Protein Kinase 14, Exip, PRKM14, PRKM15, RK.

Rabbit IgG SR: human, mouse
Immunogen: synthetic peptide. The epitope recognized by A300-707A maps to a region between residue 1 and 50 of human Mitogen Activated Protein Kinase 14 (p38 MAPK) using the numbering given in entry NP_001306.1 (GeneID 1432)
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A300-708A
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p38 MAPK is a member of the MAP (mitogen-activated protein) kinase family that is involved in cellular signaling for a wide variety of activities which includes proliferation, differentiation, and transcriptional regulation. p38 MAPK is responsive to growth factors as well as a variety of cellular stress signals such as UV light, inflammatory cytokines, and osmotic shock. Substrates of P38 MAPK include ATF2, MEF2C, MAX, CDC25B and p53. p38 MAPK is activated by MAP kinase kinases such as MAP2K3, MAP2K6, and MAP2K4. Alternate names for p38 MAPK include p38 Mitogen Activated Protein Kinase, MXI2, MAX-interacting protein 2, CSBP,CSBP1, CSBP2, CSPB1, Csaids (cytokine suppressive anti-inflammatory drug) Binding Protein, SAPK2A, stress-activated protein kinase 2A, p38, p38 Alpha, MAPK14, Mitogen Activated Protein Kinase 14, Exip, PRKM14, PRKM15, RK.

Rabbit IgG SR: human, mouse
Immunogen: synthetic peptide. The epitope recognized by A300-708A maps to a region between residue 300 and the C-terminus (residue 360) of human Mitogen Activated Protein Kinase 14 (p38 MAPK) using the numbering given in entry NP_001306.1 (GeneID 1432).
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A310-212A
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Antibodies were affinity purified using epitopes specific to p38 MAPK immobilized on solid support.

Rabbit IgG SR: human, mouse
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A300-639A
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In the process of carbohydrate metabolism, GAPDH (glyceraldehydes-3-phosphate dehydrogenase) catalyzes the oxidative phosphorylation of glyceraldehydes-3-phosphate to 1,3-diphosphoglycerate in the presence of nicotinamide adenine dinucleotide (NAD) and inorganic phosphate. In addition to its role in the oxidation of glucose, GAPDH has been shown to be involved in other cellular processes such as vesicle transport, DNA repair, DNA replication, cytoskeletal modulation, and tRNA export. Alternate names for GAPDH include aging-associated gene 9 protein, G3PD, GAPD, and MGC88685.

Rabbit IgG SR: human, mouse
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A300-640A
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In the process of carbohydrate metabolism, GAPDH (glyceraldehydes-3-phosphate dehydrogenase) catalyzes the oxidative phosphorylation of glyceraldehydes-3-phosphate to 1,3-diphosphoglycerate in the presence of nicotinamide adenine dinucleotide (NAD) and inorganic phosphate. In addition to its role in the oxidation of glucose, GAPDH has been shown to be involved in other cellular processes such as vesicle transport, DNA repair, DNA replication, cytoskeletal modulation, and tRNA export. Alternate names for GAPDH include aging-associated gene 9 protein, G3PD, GAPD, and MGC88685.

Rabbit IgG SR: human, mouse
Immunogen: synthetic peptide. The epitope recognized by A300-640A maps to a region between residues 200 and 250 of human Glyceraldehyde-3-Phosphate Dehydrogenase using the numbering given in entry NP_002037.2 (GeneID 2597).
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A300-641A
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In the process of carbohydrate metabolism, GAPDH (glyceraldehydes-3-phosphate dehydrogenase) catalyzes the oxidative phosphorylation of glyceraldehydes-3-phosphate to 1,3-diphosphoglycerate in the presence of nicotinamide adenine dinucleotide (NAD) and inorganic phosphate. In addition to its role in the oxidation of glucose, GAPDH has been shown to be involved in other cellular processes such as vesicle transport, DNA repair, DNA replication, cytoskeletal modulation, and tRNA export. Alternate names for GAPDH include aging-associated gene 9 protein, G3PD, GAPD, and MGC88685.

Rabbit IgG SR: human, mouse
Immunogen: synthetic peptide. The epitope recognized by A300-641A maps to a region between residues 250 and 300 of human Glyceraldehyde-3-Phosphate Dehydrogenase using the numbering given in entry NP_002037.2 (GeneID 2597).
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A300-642A
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In the process of carbohydrate metabolism, GAPDH (glyceraldehydes-3-phosphate dehydrogenase) catalyzes the oxidative phosphorylation of glyceraldehydes-3-phosphate to 1,3-diphosphoglycerate in the presence of nicotinamide adenine dinucleotide (NAD) and inorganic phosphate. In addition to its role in the oxidation of glucose, GAPDH has been shown to be involved in other cellular processes such as vesicle transport, DNA repair, DNA replication, cytoskeletal modulation, and tRNA export. Alternate names for GAPDH include aging-associated gene 9 protein, G3PD, GAPD, and MGC88685.

Rabbit IgG SR: human
Immunogen: synthetic peptide. The epitope recognized by A300-642A maps to a region between residues 300 and the C-terminus (residue 335) of human Glyceraldehyde-3-Phosphate Dehydrogenase using the numbering given in entry NP_002037.2 (GeneID 2597).
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A303-878A
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In the process of carbohydrate metabolism, GAPDH (glyceraldehydes-3-phosphate dehydrogenase) catalyzes the oxidative phosphorylation of glyceraldehydes-3-phosphate to 1,3-diphosphoglycerate in the presence of nicotinamide adenine dinucleotide (NAD) and inorganic phosphate. In addition to its role in the oxidation of glucose, GAPDH has been shown to be involved in other cellular processes such as vesicle transport, DNA repair, DNA replication, cytoskeletal modulation, and tRNA export.

Goat IgG SR: human, mouse
Immunogen: Synthetic peptide. The epitope recognized by A303-878A maps to a region between residue 175 and 225 of human Glyceraldehyde-3-Phosphate Dehydrogenase using the numbering given in entry NP_002037.2 (GeneID 2597).
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A310-188A
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Antibody was affinity purified using an epitope specific to GAPDH immobilized on solid support.

Rabbit IgG SR: human, mouse
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A500-005A
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In the process of carbohydrate metabolism, GAPDH (glyceraldehydes-3-phosphate dehydrogenase) catalyzes the oxidative phosphorylation of glyceraldehydes-3-phosphate to 1,3-diphosphoglycerate in the presence of nicotinamide adenine dinucleotide (NAD) and inorganic phosphate. In addition to its role in the oxidation of glucose, GAPDH has been shown to be involved in other cellular processes such as vesicle transport, DNA repair, DNA replication, cytoskeletal modulation, and tRNA export. Alternate names for GAPDH include aging-associated gene 9 protein, G3PD, GAPD, and MGC88685.

Mouse IgG SR: human
Immunogen: synthetic peptide. The epitope recognized by A500-005A maps to a region between residues 150 and 200 of human Glyceraldehyde-3-Phosphate Dehydrogenase using the numbering given in entry NP_002037.2 (GeneID 2597).
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A301-660A
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c-Abl is the human cellular homolog of a the v-Abl viral oncogene. v-Abl was originally discovered as a mouse cell-derived sequence in the genome of the Abelson murine leukemia virus (A-MuLV), a transforming retrovirus isolated by the laboratory of Dr. H.T. Abelson. c-Abl is a tyrosine kinase from the Src-family of tyrosine kinases that localizes to both the cytoplasm and nucleus. It bears an SH2 (src-homology 2) and SH3 (src-homology 3) domain responsible for mediating c-Abl protein-protein interactions. c-Abl is implicated to play a role in multiple cellular processes such as cell cycle checkpoint signaling, apoptosis, cell differentiation, cell adhesion, and transcriptional regulation. Chromosomal translocations involving the c-Abl gene are associated with human leukemias. Alternate names for c-Abl include proto-oncogene tyrosine-protein kinase ABL1, Abelson murine leukemia viral oncogene homolog 1, p150, ABL1, ABL, and JTK7.

Rabbit IgG SR: human
Immunogen: synthetic peptide. The epitope recognized by A301-660A maps to a region between residue 550 and 600 of human v-abl Abelson murine leukemia viral oncogene homolog 1 using the numbering given in entry NP_005148.2 (GeneID 25).
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A301-661A
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c-Abl is the human cellular homolog of a the v-Abl viral oncogene. v-Abl was originally discovered as a mouse cell-derived sequence in the genome of the Abelson murine leukemia virus (A-MuLV), a transforming retrovirus isolated by the laboratory of Dr. H.T. Abelson. c-Abl is a tyrosine kinase from the Src-family of tyrosine kinases that localizes to both the cytoplasm and nucleus. It bears an SH2 (src-homology 2) and SH3 (src-homology 3) domain responsible for mediating c-Abl protein-protein interactions. c-Abl is implicated to play a role in multiple cellular processes such as cell cycle checkpoint signaling, apoptosis, cell differentiation, cell adhesion, and transcriptional regulation. Chromosomal translocations involving the c-Abl gene are associated with human leukemias. Alternate names for c-Abl include proto-oncogene tyrosine-protein kinase ABL1, Abelson murine leukemia viral oncogene homolog 1, p150, ABL1, ABL, and JTK7.

Rabbit IgG SR: human
Immunogen: synthetic peptide. The epitope recognized by A301-661A maps to a region between residue 850 and 900 of human v-abl Abelson murine leukemia viral oncogene homolog 1 using the numbering given in entry NP_005148.2 (GeneID 25).
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A310-589A
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1 each of A301-660A and A301-661A

Rabbit IgG SR: human
Immunogen: synthetic peptide
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IHC-00405
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c-Abl is the human cellular homolog of a the v-Abl viral oncogene. v-Abl was originally discovered as a mouse cell-derived sequence in the genome of the Abelson murine leukemia virus (A-MuLV), a transforming retrovirus isolated by the laboratory of Dr. H.T. Abelson. c-Abl is a tyrosine kinase from the Src-family of tyrosine kinases that localizes to both the cytoplasm and nucleus. It bears an SH2 (src-homology 2) and SH3 (src-homology 3) domain responsible for mediating c-Abl protein-protein interactions. c-Abl is implicated to play a role in multiple cellular processes such as cell cycle checkpoint signaling, apoptosis, cell differentiation, cell adhesion, and transcriptional regulation. Chromosomal translocations involving the c-Abl gene are associated with human leukemias. Alternate names for c-Abl include proto-oncogene tyrosine-protein kinase ABL1, Abelson murine leukemia viral oncogene homolog 1, p150, ABL1, ABL, and JTK7.

Rabbit IgG SR: human
Immunogen: synthetic peptide. The epitope recognized by IHC-00405 maps to a region between residue 850 and 900 of human v-abl Abelson murine leukemia viral oncogene homolog 1 using the numbering given in entry NP_005148.2 (GeneID 25).
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A303-712A
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The insulin receptor is a receptor tyrosine kinase that mediates the pleiotropic actions of insulin. Binding of insulin leads to phosphorylation of several intracellular substrates, including, insulin receptor substrates (IRS1, 2, 3, 4), SHC, GAB1, CBL and other signaling intermediates to stimulate uptake of glucose. The insulin receptor is synthesized as a single polypeptide that is cleaved to generate an alpha and beta subunit. The subunit structure of the insulin receptor consists of a tetramer of two alpha and two beta chains linked by disulfide bonds. Alternative names for insulin receptor include CD220, INSR, and HHF5.

Rabbit IgG SR: human, mouse
Immunogen: Synthetic peptide. The epitope recognized by A303-712A maps to a region between residue 1332 and 1382 of human Insulin Receptor, beta Subunit using the numbering given in entry NP_000199.2 (GeneID 3643).
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A303-811A
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Superoxide dismutase 1 (SOD1) binds copper and zinc ions and is one of two isozymes responsible for destroying free superoxide radicals in the body. SOD1 is a soluble cytoplasmic protein, acting as a homodimer to convert naturally-occuring but harmful superoxide radicals to molecular oxygen and hydrogen peroxide. The other isozyme is a mitochondrial protein. Mutations in this gene have been implicated as causes of familial amyotrophic lateral sclerosis [taken from NCBI Entrez Gene (Gene ID: 6647)].

Rabbit IgG SR: human
Immunogen: Synthetic peptide. The epitope recognized by A303-811A maps to a region between residue 54 and 104 of human Superoxide Dismutase 1 using the numbering given in entry NP_000445.1 (GeneID 6647).
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A303-812A
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Superoxide dismutase 1 (SOD1) binds copper and zinc ions and is one of two isozymes responsible for destroying free superoxide radicals in the body. SOD1 is a soluble cytoplasmic protein, acting as a homodimer to convert naturally-occuring but harmful superoxide radicals to molecular oxygen and hydrogen peroxide. The other isozyme is a mitochondrial protein. Mutations in this gene have been implicated as causes of familial amyotrophic lateral sclerosis [taken from NCBI Entrez Gene (Gene ID: 6647)].

Rabbit IgG SR: human
Immunogen: Synthetic peptide. The epitope recognized by A303-812A maps to a region between residue 104 and 154 of human Superoxide Dismutase 1 using the numbering given in entry NP_000445.1 (GeneID 6647).
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A311-401A
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1 each of A303-811A and A303-812A

Rabbit IgG SR: human
Immunogen: Synthetic peptide. Antibodies were affinity purified using epitopes specific to SOD1 immobilized on solid support.
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A300-463A
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Tuberous sclerosis 2 protein (TSC2) forms a heterodimer with TSC1 to integrate cellular growth and stress signals. Defects in the TSC1 and TSC2 gene are responsible for the genetic disorder tuberous sclerosis. The TSC1/TSC2 complex functions in the mTOR pathway by negatively regulating mTOR activity via the small GTP-binding protein Rheb. TSC2 also been shown to interact with FOXO1 transcription factor. TSC2 is also called tuberin, LAM, TSC4, and FLJ43106.

Rabbit IgG SR: human
Immunogen: synthetic peptide. The epitope recognized by A300-463A maps to a region between residues 1750 and the C-terminus (residue 1807) of human Tuberous Sclerosis 2 using the numbering given in Swiss-Prot entry P49815 (GeneID 7249).
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A300-526A
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Tuberous sclerosis 2 protein (TSC2) forms a heterodimer with TSC1 to integrate cellular growth and stress signals. Defects in the TSC1 and TSC2 gene are responsible for the genetic disorder tuberous sclerosis. The TSC1/TSC2 complex functions in the mTOR pathway by negatively regulating mTOR activity via the small GTP-binding protein Rheb. TSC2 also been shown to interact with FOXO1 transcription factor. TSC2 is also called tuberin, LAM, TSC4, and FLJ43106.

Rabbit IgG SR: human
Immunogen: synthetic peptide. The epitope recognized by A300-526A maps to a region between residues 1 and 50 of human Tuberous Sclerosis 2 using the numbering given in Swiss-Prot entry P49815 (GeneID 7249).
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A310-150A
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Antibodies were affinity purified using epitopes specific to TSC2 immobilized on solid support.

Rabbit IgG SR: human
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A301-692A
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Focal adhesion kinase (FAK) is a non-receptor protein-tyrosine kinase that localizes to the cytoplasm and is concentrated in focal adhesions, macromolecular assemblies that form a communicative link between the cell and the extracellular matrix. FAK signaling is stimulated by integrin-mediated responses, as well as growth factors, chemokines, and G-protein-linked receptors. FAK signaling influences cell motility, invasion, and survival. Alternate names for FAK include FADK1, pp125FAK, protein-tyrosine kinase 2, PTK2 protein tyrosine kinase 2, PTK2, and FAK1.

Rabbit IgG SR: human
Immunogen: synthetic peptide. The epitope recognized by A301-692A maps to a region between residue 325 and 375 of human focal adhesion kinase 1 using the numbering given in entry NP_005598.3 (GeneID 5747).
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A301-693A
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Focal adhesion kinase (FAK) is a non-receptor protein-tyrosine kinase that localizes to the cytoplasm and is concentrated in focal adhesions, macromolecular assemblies that form a communicative link between the cell and the extracellular matrix. FAK signaling is stimulated by integrin-mediated responses, as well as growth factors, chemokines, and G-protein-linked receptors. FAK signaling influences cell motility, invasion, and survival. Alternate names for FAK include FADK1, pp125FAK, protein-tyrosine kinase 2, PTK2 protein tyrosine kinase 2, PTK2, and FAK1.

Rabbit IgG SR: human
Immunogen: synthetic peptide. The epitope recognized by A301-693A maps to a region between residue 1002 and 1052 of human focal adhesion kinase 1 using the numbering given in entry NP_005598.3 (GeneID 5747).
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A310-600A
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1 each of A301-692A and A301-693A

Rabbit IgG SR: human
Immunogen: synthetic peptide
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A301-375A
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PARP1 (Poly-ADP-ribose polymerase 1) is a member of PARP family of enzymes that transfer the ADP-D-ribosyl group of NAD(plus) to an acceptor carboxyl group on proteins. PARP1 catalyzes the poly-ADP-ribosylation of histone and non-histone proteins in response to DNA damage. The over-activation of PARP-1 in response to DNA damage has been shown to promote cell and tissue injury. This observation has initiated research into the therapeutic potential of PARP1 inhibitors in the treatment of cancer, cardiovascular disease, and brain injury. Alternate names for PARP1 include ADPRT, NAD(plus) ADP-ribosyltransferase 1, poly-ADP-ribose synthase 1, ADPRT, PPOL, PARP, PARP-1, and pADPRT-1.

Rabbit IgG SR: human
Immunogen: synthetic peptide. The epitope recognized by A301-375A maps to a region between residue 1 and 50 of human poly (ADP-ribose) polymerase family, member 1 using the numbering given in entry NP_001609.1 (GeneID 142).
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A301-376A
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PARP1 (Poly-ADP-ribose polymerase 1) is a member of PARP family of enzymes that transfer the ADP-D-ribosyl group of NAD(plus) to an acceptor carboxyl group on proteins. PARP1 catalyzes the poly-ADP-ribosylation of histone and non-histone proteins in response to DNA damage. The over-activation of PARP-1 in response to DNA damage has been shown to promote cell and tissue injury. This observation has initiated research into the therapeutic potential of PARP1 inhibitors in the treatment of cancer, cardiovascular disease, and brain injury. Alternate names for PARP1 include ADPRT, NAD(plus) ADP-ribosyltransferase 1, poly-ADP-ribose synthase 1, ADPRT, PPOL, PARP, PARP-1, and pADPRT-1.

Rabbit IgG SR: human
Immunogen: synthetic peptide. The epitope recognized by A301-376A maps to a region between residue 50 and 100 of human poly (ADP-ribose) polymerase family, member 1 using the numbering given in entry NP_001609.1 (GeneID 142).
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A310-476A
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1 each of A301-375A and A301-376A

Rabbit IgG SR: human
Immunogen: synthetic peptide
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IHC-00279
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PARP1 (Poly-ADP-ribose polymerase 1) is a member of PARP family of enzymes that transfer the ADP-D-ribosyl group of NAD(plus) to an acceptor carboxyl group on proteins. PARP1 catalyzes the poly-ADP-ribosylation of histone and non-histone proteins in response to DNA damage. The over-activation of PARP-1 in response to DNA damage has been shown to promote cell and tissue injury. This observation has initiated research into the therapeutic potential of PARP1 inhibitors in the treatment of cancer, cardiovascular disease, and brain injury. Alternate names for PARP1 include ADPRT, NAD(plus) ADP-ribosyltransferase 1, poly-ADP-ribose synthase 1, ADPRT, PPOL, PARP, PARP-1, and pADPRT-1.

Rabbit IgG SR: human
Immunogen: synthetic peptide. The epitope recognized by IHC-00279 maps to a region between residue 50 and 100 of human poly (ADP-ribose) polymerase family, member 1 using the numbering given in entry NP_001609.1 (GeneID 142).
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A300-135A
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Ataxia telangiectasia, mutated (ATM) is the gene responsible for the neurodegenerative disease ataxia telangiectasia (AT). AT is characterized by neurodegeneration, immune dysfunction, sensitivity to DNA damage, and cancer predisposition. ATM is a protein kinase central to the DNA damage response. In response to DNA double-strand breaks (DSBs), ATM initiates a signaling cascade that involves the phosphorylation of a multitude of substrates which include p53, BRCA1, p53 binding protein, CHK2, RAD9, RAD17, and MDM4. Alternate names for ATM include AT1, ATA, ATC, ATD, ATE, ATDC, TEL1, TELO1, MGC74674, Serine protein kinase ATM, human phosphatidylinositol 3 kinase homolog, AT protein, and DKFZp781A0353.

Goat IgG SR: human, mouse
Immunogen: synthetic peptide. The epitope recognized by A300-135A maps to a region between residues 1750 and 1800 of human Ataxia Telangiectasia Mutated using the numbering given in entry NP_000042.2 (GeneID 472).
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A300-136A
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Ataxia telangiectasia, mutated (ATM) is the gene responsible for the neurodegenerative disease ataxia telangiectasia (AT). AT is characterized by neurodegeneration, immune dysfunction, sensitivity to DNA damage, and cancer predisposition. ATM is a protein kinase central to the DNA damage response. In response to DNA double-strand breaks (DSBs), ATM initiates a signaling cascade that involves the phosphorylation of a multitude of substrates which include p53, BRCA1, p53 binding protein, CHK2, RAD9, RAD17, and MDM4. Alternate names for ATM include AT1, ATA, ATC, ATD, ATE, ATDC, TEL1, TELO1, MGC74674, Serine protein kinase ATM, human phosphatidylinositol 3 kinase homolog, AT protein, and DKFZp781A0353.

Goat IgG SR: human, mouse
Immunogen: synthetic peptide. The epitope recognized by A300-136A maps to a region between residues 2550 and 2600 of human Ataxia Telangiectasia Mutated using the numbering given in entry NP_000042.2 (GeneID 472).
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A300-299A
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Ataxia telangiectasia, mutated (ATM) is the gene responsible for the neurodegenerative disease ataxia telangiectasia (AT). AT is characterized by neurodegeneration, immune dysfunction, sensitivity to DNA damage, and cancer predisposition. ATM is a protein kinase central to the DNA damage response. In response to DNA double-strand breaks (DSBs), ATM initiates a signaling cascade that involves the phosphorylation of a multitude of substrates which include p53, BRCA1, p53 binding protein, CHK2, RAD9, RAD17, and MDM4. Alternate names for ATM include AT1, ATA, ATC, ATD, ATE, ATDC, TEL1, TELO1, MGC74674, Serine protein kinase ATM, human phosphatidylinositol 3 kinase homolog, AT protein, and DKFZp781A0353.

Rabbit IgG SR: human
Immunogen: synthetic peptide. The epitope recognized by A300-299A maps to a region between residues 2550 and 2600 of human ataxia telangiectasia mutated using the numbering given in SwissProt entry Q13315 (GeneID 472).
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A310-034A
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Antibodies were affinity purified using epitopes specific to ATM immobilized on solid support.

Rabbit IgG SR: human, mouse
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IHC-00034
IHC Erklärungen der Abkürzungen ansehen.
Ataxia telangiectasia, mutated (ATM) is the gene responsible for the neurodegenerative disease ataxia telangiectasia (AT). AT is characterized by neurodegeneration, immune dysfunction, sensitivity to DNA damage, and cancer predisposition. ATM is a protein kinase central to the DNA damage response. In response to DNA double-strand breaks (DSBs), ATM initiates a signaling cascade that involves the phosphorylation of a multitude of substrates which include p53, BRCA1, p53 binding protein, CHK2, RAD9, RAD17, and MDM4. Alternate names for ATM include AT1, ATA, ATC, ATD, ATE, ATDC, TEL1, TELO1, MGC74674, Serine protein kinase ATM, human phosphatidylinositol 3 kinase homolog, AT protein, and DKFZp781A0353.

Rabbit IgG SR: human
Immunogen: synthetic peptide. The epitope recognized by IHC-00034 maps to a region between residue 2550 and 2600 of human ataxia telangiectasia mutated using the numbering given in SwissProt entry Q13315 (GeneID 472).
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S300-135
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Goat anti-human ATM affinity purified Antibodies were coupled to agarose beads using a cyanogen bromide method.

Goat IgG SR: human, mouse
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S300-136
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Goat anti-human ATM affinity purified Antibodies were coupled to agarose beads using a cyanogen bromide method.

Goat IgG SR: human, mouse
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A302-060A
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Extracellular signal-regulated kinase 1 (ERK1/p44) is also known as mitogen-activated protein kinase 3 (MAPK3). ERK1 is part of a signal transduction pathway that begins with the small GTPase Ras and continues through a cascade of protein kinases that include Raf and MEK. Activation of this signaling pathway influences many cellular processes such as proliferation, differentiation and survival. ERK1 is very similar in sequence to ERK2/p42 and the activities of both ERK1 and ERK2 are usually considered together as total ERK activity. More recent evidence has shown that ERK1 and ERK2 are not functionally redundant and may have very different and specific roles. Alternate names for ERK1 include p44-MAPK, ERT2, p44-ERK1, MAPK 1, microtubule-associated protein kinase 2, and PRKM3.

Rabbit IgG SR: human
Immunogen: synthetic peptide. The epitope recognized by A302-060A maps to a region between residue 329 and 379 of human extracellular signal-related kinase 1 (mitogen-activated protein kinase 3) using the numbering given in entry NP_002737.2 (GeneID 5595).
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A303-608A
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Extracellular signal-regulated kinase 1 (ERK1/p44), also known as mitogen-activated protein kinase 3 (MAPK3), and extracellular signal-regulated kinase 2 (ERK2/p42), also known as mitogen-activated protein kinase 1 (MAPK1), are part of a signal transduction pathway that begins with the small GTPase Ras and continues through a cascade of protein kinases that include Raf and MEK. Activation of this signaling pathway influences many cellular processes such as proliferation, differentiation and survival. ERK1 is very similar in sequence to ERK2/p42 and the activities of both ERK1 and ERK2 are usually considered together as total ERK activity. More recent evidence has shown that ERK1 and ERK2 are not functionally redundant and may have very different and specific roles. Alternate names for ERK1 include p44-MAPK, ERT2, p44-ERK1, MAPK 1, microtubule-associated protein kinase 2, and PRKM3. Alternative names for ERK2 include p42-MAPK, ERT1, MAPK2, PRKM1, and PRKM2.

Rabbit IgG SR: human
Immunogen: Synthetic peptide. The epitope recognized by A303-608A maps to a region of human Extracellular Signal-Regulated Kinase-1 surrounding threonine 202 and tyrosine 204 (when using the numbering according to NCBI entry NP_002737.2, GeneID 5595) and human Extra
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A303-609A
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Extracellular signal-regulated kinase 1 (ERK1/p44), also known as mitogen-activated protein kinase 3 (MAPK3), and extracellular signal-regulated kinase 2 (ERK2/p42), also known as mitogen-activated protein kinase 1 (MAPK1), are part of a signal transduction pathway that begins with the small GTPase Ras and continues through a cascade of protein kinases that include Raf and MEK. Activation of this signaling pathway influences many cellular processes such as proliferation, differentiation and survival. ERK1 is very similar in sequence to ERK2/p42 and the activities of both ERK1 and ERK2 are usually considered together as total ERK activity. More recent evidence has shown that ERK1 and ERK2 are not functionally redundant and may have very different and specific roles. Alternate names for ERK1 include p44-MAPK, ERT2, p44-ERK1, MAPK 1, microtubule-associated protein kinase 2, and PRKM3. Alternative names for ERK2 include p42-MAPK, ERT1, MAPK2, PRKM1, and PRKM2.

Goat IgG SR: human
Immunogen: Synthetic peptide. The epitope recognized by A303-608A maps to a region of human Extracellular Signal-Regulated Kinase-1 surrounding threonine 202 and tyrosine 204 (when using the numbering according to NCBI entry NP_002737.2, GeneID 5595) and human Extra
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A311-325A
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1 each of A303-608A and A303-609A
IgG SR: human
Immunogen: Synthetic peptide.
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IHC-00505
IHC Erklärungen der Abkürzungen ansehen.
Extracellular signal-regulated kinase 1 (ERK1/p44) is also known as mitogen-activated protein kinase 3 (MAPK3). ERK1 is part of a signal transduction pathway that begins with the small GTPase Ras and continues through a cascade of protein kinases that include Raf and MEK. Activation of this signaling pathway influences many cellular processes such as proliferation, differentiation and survival. ERK1 is very similar in sequence to ERK2/p42 and the activities of both ERK1 and ERK2 are usually considered together as total ERK activity. More recent evidence has shown that ERK1 and ERK2 are not functionally redundant and may have very different and specific roles. Alternate names for ERK1 include p44-MAPK, ERT2, p44-ERK1, MAPK 1, microtubule-associated protein kinase 2, and PRKM3.

Rabbit IgG SR: human
Immunogen: synthetic peptide. The epitope recognized by IHC-00505 maps to a region between residue 329 and 379 of human extracellular signal-related kinase 1 (mitogen-activated protein kinase 3) using the numbering given in entry NP_002737.2 (GeneID 5595).
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A301-827A
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IKK-beta (Inhibitor of nuclear factor kappa B kinase subunit beta) is one of three subunits that comprise the IKK complex. The IKK complex consists of two catalytic subunits, IKK-alpha and IKK-beta, and a regulatory subunit IKK-gamma/NEMO. As a kinase, IKK functions to phosphorylate members of the NF-kappa B inhibitor proteins, the I-kappa B proteins. Phosphorylation of I-kappa B proteins results in the ubiquitination and degradation of I kappa B and the release and translocation of the NF-kappa B transcription factor to the nucleus where it may function to activate a vast number of genes. Alternative names for IKK-beta include I kappa B kinase beta, I-kappa-B kinase 2, IKK2, NF-kappa B inhibitor kinase beta, NFKBIKB, and IKBKB.

Rabbit IgG SR: human
Immunogen: synthetic peptide. The epitope recognized by A301-827A maps to a region between residue 706 and 756 of human inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta using the numbering given in entry NP_001547.1 (GeneID 3551).
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A301-695A
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B-Raf proto-oncogene serine/threonine-protein kinase (BRAF) is a member of the raf/mil family of serine/threonine kinases. BRAF is involved in transducing mitogenic signals via the MAP kinase/ERKs signaling pathway. Mutations in BRAF are involved in a wide range of cancers such as lung, non-Hodgkin lymphoma, and colorectal cancer. Defects in BRAF are also the cause of cardiofaciocutaneous syndrome (CFC), an autosomal dominant syndrome characterized by facial anomalies, heart defects, and ectodermal abnormalities. Alternate names for BRAF include murine sarcoma viral (v-raf) oncogene homolog B1, 94 kDa B-raf protein, RAFB1, and B-RAF1.

Rabbit IgG SR: human
Immunogen: synthetic peptide. The epitope recognized by A301-695A maps to a region between residue 25 and 75 of human v-raf murine sarcoma viral oncogene homolog B1 using the numbering given in entry NP_004324.2 (GeneID 673).
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IHC-00607
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B-Raf proto-oncogene serine/threonine-protein kinase (BRAF) is a member of the raf/mil family of serine/threonine kinases. BRAF is involved in transducing mitogenic signals via the MAP kinase/ERKs signaling pathway. Mutations in BRAF are involved in a wide range of cancers such as lung, non-Hodgkin lymphoma, and colorectal cancer. Defects in BRAF are also the cause of cardiofaciocutaneous syndrome (CFC), an autosomal dominant syndrome characterized by facial anomalies, heart defects, and ectodermal abnormalities. Alternate names for BRAF include murine sarcoma viral (v-raf) oncogene homolog B1, 94 kDa B-raf protein, RAFB1, and B-RAF1.

Rabbit IgG SR: human
Immunogen: synthetic peptide. The epitope recognized by IHC-00607 maps to a region between residue 25 and 75 of human v-raf murine sarcoma viral oncogene homolog B1 using the numbering given in entry NP_004324.2 (GeneID 673).
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A302-405A
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STAT3 (signal transducer and activator of transcription 3) is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated through phosphorylation in response to various cytokines and growth factors including IFNs, EGF, IL5, IL6, HGF, LIF and BMP2. This protein mediates the expression of a variety of genes in response to cell stimuli, and thus plays a key role in many cellular processes such as cell growth and apoptosis. The small GTPase Rac1 has been shown to bind and regulate the activity of this protein. PIAS3 protein is a specific inhibitor of this protein.

Rabbit IgG SR: human
Immunogen: synthetic peptide. The epitope recognized by A302-405A maps to a region between residue 675 and 725 of human signal transducer and activator of transcription 3 using the numbering given in entry NP_644805.1 (GeneID 6774).
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A302-406A
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STAT3 (signal transducer and activator of transcription 3) is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated through phosphorylation in response to various cytokines and growth factors including IFNs, EGF, IL5, IL6, HGF, LIF and BMP2. This protein mediates the expression of a variety of genes in response to cell stimuli, and thus plays a key role in many cellular processes such as cell growth and apoptosis. The small GTPase Rac1 has been shown to bind and regulate the activity of this protein. PIAS3 protein is a specific inhibitor of this protein.

Rabbit IgG SR: human, mouse
Immunogen: synthetic peptide. The epitope recognized by A302-406A maps to a region between residue 720 and 770 of human signal transducer and activator of transcription 3 using the numbering given in entry NP_644805.1 (GeneID 6774).
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A310-871A
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1 each of A302-405A and A302-406A

Rabbit IgG SR: human
Immunogen: synthetic peptide
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A300-666A
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ErbB4 is a member of the receptor tyrosine kinase family of proteins. The four members of this family are ErbB1 (Epidermal growth factor receptor, EGFR/HER1), ErbB2 (HER2/Neu), ErbB3 (HER3), and ErbB4 (HER4). The ErbB receptor members are single-pass transmembrane proteins with an extracellular ligand-binding domain and a cytoplasmic tyrosine-kinase domain. The epidermal growth factor (EGF) and its related proteins serve as the ligands for the ErbB receptors. Upon binding, the receptors homo- or heterodimerize, autophosphorylate and make contact with adapter molecules to transmit cellular signals involved in cell proliferation, survival, and differentiation. The ligands preferred by ErbB4 include neuregulins (NRG-2 and NRG-3), heparin-binding EGF-like growth factor, and betacellulin, and epiregulin. ErbB4 appears to be important to mammary gland development and lactation, however its role in breast cancer has not been unequivocally determined.

Rabbit IgG SR: human
Immunogen: synthetic peptide. The epitope recognized by A300-666A maps to a region between residues 1100 and 1150 of human v-erb-a erythroblastic leukemia viral oncogene homolog 4 using the numbering given in entry NP_005226.1 (GeneID 2066).
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A300-667A
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ErbB4 is a member of the receptor tyrosine kinase family of proteins. The four members of this family are ErbB1 (Epidermal growth factor receptor, EGFR/HER1), ErbB2 (HER2/Neu), ErbB3 (HER3), and ErbB4 (HER4). The ErbB receptor members are single-pass transmembrane proteins with an extracellular ligand-binding domain and a cytoplasmic tyrosine-kinase domain. The epidermal growth factor (EGF) and its related proteins serve as the ligands for the ErbB receptors. Upon binding, the receptors homo- or heterodimerize, autophosphorylate and make contact with adapter molecules to transmit cellular signals involved in cell proliferation, survival, and differentiation. The ligands preferred by ErbB4 include neuregulins (NRG-2 and NRG-3), heparin-binding EGF-like growth factor, and betacellulin, and epiregulin. ErbB4 appears to be important to mammary gland development and lactation, however its role in breast cancer has not been unequivocally determined.

Rabbit IgG SR: human
Immunogen: synthetic peptide. The epitope recognized by A300-667A maps to a region between residue 1250 and the C-terminus (residue 1308) of human v-erb-a erythroblastic leukemia viral oncogene homolog 4 using the numbering given in entry NP_005226.1 (GeneID 2066).
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A310-195A
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Antibody was affinity purified using an epitope specific to ErbB4 immobilized on solid support.

Rabbit IgG SR: human
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A300-712A
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Histone deacetylase 1 (HDAC1) is a class I histone deacetylase that catalyzes the removal of the acetyl group on lysine residues of the N-terminus of the core histones H2A, H2B, H3, and H4. HDAC1 is a component of multiple deacetylating complexes such as Sin3, NuRD, and CoRest that function to repress gene transcription. Alternate names for HDAC1 include RPD3L1, HD1, GON-10, and DKFZp686H12203.

Rabbit IgG SR: human
Immunogen: synthetic peptide. The epitope recognized by A300-712A maps to the N-terminus of human Histone Deacetylase 1 using the numbering given in entry NP_004955.2 (GeneID 3065).
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A300-713A
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Histone deacetylase 1 (HDAC1) is a class I histone deacetylase that catalyzes the removal of the acetyl group on lysine residues of the N-terminus of the core histones H2A, H2B, H3, and H4. HDAC1 is a component of multiple deacetylating complexes such as Sin3, NuRD, and CoRest that function to repress gene transcription. Alternate names for HDAC1 include RPD3L1, HD1, GON-10, and DKFZp686H12203.

Rabbit IgG SR: human, mouse
Immunogen: synthetic peptide. The epitope recognized by A300-713A maps to region between residue 425 and the C-terminus (residue 482) of human Histone Deacetylase 1 using the numbering given in entry NP_004955.2 (GeneID 3065).
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A310-214A
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Antibodies were affinity purified using epitopes specific to HDAC1 immobilized on solid support.

Rabbit IgG SR: human, mouse
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IHC-00056
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Histone deacetylase 1 (HDAC1) is a class I histone deacetylase that catalyzes the removal of the acetyl group on lysine residues of the N-terminus of the core histones H2A, H2B, H3, and H4. HDAC1 is a component of multiple deacetylating complexes such as Sin3, NuRD, and CoRest that function to repress gene transcription. Alternate names for HDAC1 include RPD3L1, HD1, GON-10, and DKFZp686H12203.

Rabbit IgG SR: human, mouse
Immunogen: synthetic peptide. The epitope recognized by IHC-00056 maps to a region between residue 425 and the C-terminus (residue 482) of human Histone Deacetylase 1 using the numbering given in entry NP_004955.2 (GeneID 3065).
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A300-822A
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Histone H3 is one of four histone proteins that assemble into an octamer to form the nucleosome core and serve to spool and compact DNA into chromatin. Histones are subject to a complex set of post-translational modifications (acetylation, methylation, phosphorylation, ubiquitination, sumoylation, citrullination, and ADP ribosylation) that are important to the regulation of gene transcription, DNA replication, and DNA repair.

Rabbit IgG SR: human
Immunogen: synthetic peptide. The epitope recognized by A300-822A maps to a region between residue 1 and 50 of human Histone H3 using the numbering given in entry NP_003520.1 (GeneID 8350).
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A300-823A
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Histone H3 is one of four histone proteins that assemble into an octamer to form the nucleosome core and serve to spool and compact DNA into chromatin. Histones are subject to a complex set of post-translational modifications (acetylation, methylation, phosphorylation, ubiquitination, sumoylation, citrullination, and ADP ribosylation) that are important to the regulation of gene transcription, DNA replication, and DNA repair.

Rabbit IgG SR: human
Immunogen: synthetic peptide. The epitope recognized by A300-823A maps to a region between residue 100 and the C-terminus (residue 135) of human Histone H3 using the numbering given in entry NP_003520.1 (GeneID 8350).
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A301-844A
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Phosphorylation at Ser10 of histone H3 is tightly correlated with chromosome condensation during both mitosis and meiosis.

Rabbit IgG SR: human
Immunogen: synthetic phospho-peptide. Immunogen for A301-844A was a synthetic phosphorylated peptide, which represented a portion of human Histone H3 surrounding serine 10 according to the numbering given in entry NP_003520.1 (GeneID 8350).
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A310-257A
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Antibodies were affinity purified using epitopes specific to Histone H3 immobilized on solid support.

Rabbit IgG SR: human
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E300-001B
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Extra supply of antibody to be used with the Histone H3 PathProfiler ELISA kit (#E300-001).

Rabbit IgG
Immunogen: synthetic peptide
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IHC-00061
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Histone H3 is one of four histone proteins that assemble into an octamer to form the nucleosome core and serve to spool and compact DNA into chromatin. Histones are subject to a complex set of post-translational modifications (acetylation, methylation, phosphorylation, ubiquitination, sumoylation, citrullination, and ADP ribosylation) that are important to the regulation of gene transcription, DNA replication, and DNA repair.

Rabbit IgG SR: human, mouse
Immunogen: synthetic peptide. Immunogen for IHC-00061 was a synthetic phosphorylated peptide, which represented a portion of human Histone H3 surrounding Serine 10 according to the numbering given in entry NP_003520.1 (GeneID 8350).
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IHC-00465
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Histone H3 is one of four histone proteins that assemble into an octamer to form the nucleosome core and serve to spool and compact DNA into chromatin. Histones are subject to a complex set of post-translational modifications (acetylation, methylation, phosphorylation, ubiquitination, sumoylation, citrullination, and ADP ribosylation) that are important to the regulation of gene transcription, DNA replication, and DNA repair.

Rabbit IgG SR: human, mouse
Immunogen: synthetic peptide. The epitope recognized by IHC-00465 maps to a region between residue 100 and the C-terminus (residue 135) of human Histone H3 using the numbering given in entry NP_003520.1 (GeneID 8350).
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A300-646A
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Histone H4 is one of four histone proteins that assemble into an octamer to form the nucleosome core and serve to spool and compact DNA into chromatin. Histones are subject to a complex set of post-translational modifications (acetylation, methylation, phosphorylation, ubiquitination, sumoylation, citrullination, and ADP ribosylation) that are important to the regulation of gene transcription, DNA replication, and DNA repair.

Rabbit IgG SR: human
Immunogen: synthetic peptide. The epitope recognized by A300-646A maps to a region between residues 1 and 50 of human Histone H4 using the numbering given in entry NP_778224.1 (GeneID 121504).
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A300-647A
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Histone H4 is one of four histone proteins that assemble into an octamer to form the nucleosome core and serve to spool and compact DNA into chromatin. Histones are subject to a complex set of post-translational modifications (acetylation, methylation, phosphorylation, ubiquitination, sumoylation, citrullination, and ADP ribosylation) that are important to the regulation of gene transcription, DNA replication, and DNA repair.

Rabbit IgG SR: human
Immunogen: synthetic peptide. The epitope recognized by A300-647A maps to a region between residue 50 and the C-terminus (residue 103) of human Histone H4 using the numbering given in entry NP_778224.1 (GeneID 121504).
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A310-189A
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Antibody was affinity purified using an epitope specific to Histone H4 immobilized on solid support.

Rabbit IgG SR: human
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IHC-00098
IHC Erklärungen der Abkürzungen ansehen.
Histone H4 is one of four histone proteins that assemble into an octamer to form the nucleosome core and serve to spool and compact DNA into chromatin. Histones are subject to a complex set of post-translational modifications (acetylation, methylation, phosphorylation, ubiquitination, sumoylation, citrullination, and ADP ribosylation) that are important to the regulation of gene transcription, DNA replication, and DNA repair.

Rabbit IgG SR: human
Immunogen: synthetic peptide. The epitope recognized by IHC-00098 maps to a region between residue 50 and the C-terminus (residue 103) of human Histone H4 using the numbering given in entry NP_778224.1 (GeneID 121504).
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A300-687A
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Sirt1 is one of seven members of the sirtuin family of proteins that are homologous to the yeast silent information regulator 2 (Sir2), a NADplus-dependent protein deacetylase that plays a role in lifespan in lower eukaryotes. The sirtuins are diverse in their cellular functions, and are important to the regulation of oxidative stress, and metabolism. Sirt 1 is localized to the nucleus and possesses deacetylase activity. Sirt 1 has been shown to be able to deacetylate p53, Ku70, NF-kappaB and forkhead proteins to mediate cellular resistance to stress.

Rabbit IgG SR: human
Immunogen: synthetic peptide. The epitope recognized by A300-687A maps to a region between residues 25 and 75 of human Sirtuin (Silent Mating Type Information Regulation 2) type 1 using the numbering given in entry NP_036370.2 (GeneID 23411).
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A300-688A
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Sirt1 is one of seven members of the sirtuin family of proteins that are homologous to the yeast silent information regulator 2 (Sir2), a NADplus-dependent protein deacetylase that plays a role in lifespan in lower eukaryotes. The sirtuins are diverse in their cellular functions, and are important to the regulation of oxidative stress, and metabolism. Sirt 1 is localized to the nucleus and possesses deacetylase activity. Sirt 1 has been shown to be able to deacetylate p53, Ku70, NF-kappaB and forkhead proteins to mediate cellular resistance to stress.

Rabbit IgG SR: human
Immunogen: synthetic peptide. The epitope recognized by A300-688A maps to a region between residue 700 and the C-terminus (residue 747) of human Silent Mating Type Information Regulation 2 homolog 1 using the numbering given in entry NP_036370.2 (GeneID 23411).
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A310-204A
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Antibodies were affinity purified using epitopes specific to Sirt1 immobilized on solid support.

Rabbit IgG SR: human
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A303-663A
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Cyclin-dependent kinase 1 (CDK1) is a member of the Ser/Thr protein kinase family. CDK1 is a catalytic subunit of the highly conserved protein kinase complex known as M-phase promoting factor (MPF), which is essential for G1/S and G2/M phase transitions of eukaryotic cell cycle. Mitotic cyclins stably associate with this protein and function as regulatory subunits. The kinase activity of CKD1 is controlled by cyclin accumulation and destruction through the cell cycle. The phosphorylation and dephosphorylation of this protein also play important regulatory roles in cell cycle control. Alternative names for CDK1 include cell division control protein 2 homolog, cell division protein kinase 1, p34 protein kinase, CDC2, CDC28A, CDKN1, and P34CDC2. [taken from NCBI Entrez Gene (Gene ID: 983)]

Rabbit IgG SR: human
Immunogen: Synthetic peptide. The epitope recognized by A303-663A maps to a region between residue 1 and 50 of human Cyclin-Dependent Kinase 1 using the numbering given in entry NP_001777.1 (GeneID 983).
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A303-664A
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Cyclin-dependent kinase 1 (CDK1) is a member of the Ser/Thr protein kinase family. CDK1 is a catalytic subunit of the highly conserved protein kinase complex known as M-phase promoting factor (MPF), which is essential for G1/S and G2/M phase transitions of eukaryotic cell cycle. Mitotic cyclins stably associate with this protein and function as regulatory subunits. The kinase activity of CKD1 is controlled by cyclin accumulation and destruction through the cell cycle. The phosphorylation and dephosphorylation of this protein also play important regulatory roles in cell cycle control. Alternative names for CDK1 include cell division control protein 2 homolog, cell division protein kinase 1, p34 protein kinase, CDC2, CDC28A, CDKN1, and P34CDC2. [taken from NCBI Entrez Gene (Gene ID: 983)]

Rabbit IgG SR: human
Immunogen: Synthetic peptide. The epitope recognized by A303-664A maps to a region between residue 225 and 275 of human Cyclin-Dependent Kinase 1 using the numbering given in entry NP_001777.1 (GeneID 983).
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A311-344A
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1 each of A303-663A and A303-664A

Rabbit IgG SR: human
Immunogen: Synthetic peptide. Antibodies were affinity purified using epitopes specific to CDK1 immobilized on solid support.
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A300-041A
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DNA methyltransferase 1 (DNMT1) catalyzes the methylation of the 5-cytosine in the dinucleotide sequence, CpG. DNMT1 is thought to be responsible for the regulation of methylation patterns that are important in development and influence gene expression in a time- and tissue-specific manner. Alternate names for DNMT1 include DNA (cytosine-5)-methyltransferase 1, DNA methyltransferase Hsal, DNA MTase Hsal, MCMT, M.Hsal, AIM, DNMT, CXXC9, FLJ16293, and MGC104992.

Rabbit IgG SR: human
Immunogen: synthetic peptide. The epitope recognized by A300-041A maps to a region between residue 350 and 400 of human DNA-Methyltranserase 1 using the numbering given in entry NP_001370.1 (GeneID 1786).
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A300-042A
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DNA methyltransferase 1 (DNMT1) catalyzes the methylation of the 5-cytosine in the dinucleotide sequence, CpG. DNMT1 is thought to be responsible for the regulation of methylation patterns that are important in development and influence gene expression in a time- and tissue-specific manner. Alternate names for DNMT1 include DNA (cytosine-5)-methyltransferase 1, DNA methyltransferase Hsal, DNA MTase Hsal, MCMT, M.Hsal, AIM, DNMT, CXXC9, FLJ16293, and MGC104992.

Rabbit IgG SR: human
Immunogen: synthetic peptide. The epitope recognized by A300-042A maps to a region between residue 700 and 750 of human DNA-Methyltranserase 1 using the numbering given in entry NP_001370.1 (GeneID 1786).
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A300-043A
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DNA methyltransferase 1 (DNMT1) catalyzes the methylation of the 5-cytosine in the dinucleotide sequence, CpG. DNMT1 is thought to be responsible for the regulation of methylation patterns that are important in development and influence gene expression in a time- and tissue-specific manner. Alternate names for DNMT1 include DNA (cytosine-5)-methyltransferase 1, DNA methyltransferase Hsal, DNA MTase Hsal, MCMT, M.Hsal, AIM, DNMT, CXXC9, FLJ16293, and MGC104992.

Rabbit IgG SR: human
Immunogen: synthetic peptide. The epitope recognized by A300-043A maps to a region between residue 1075 and 1125 of human DNA-Methyltranserase 1 using the numbering given in entry NP_001370.1 (GeneID 1786).
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A310-008A
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Antibodies were affinity purified using epitopes specific to DNMT1 immobilized on solid support.

Rabbit IgG SR: human
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A300-316A
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Tuberous sclerosis 1 protein (TSC1) forms a heterodimer with TSC2 to integrate cellular growth and stress signals. Defects in the TSC1 and TSC2 gene are responsible for the genetic disorder tuberous sclerosis. The TSC1/TSC2 complex functions in the mTOR pathway by negatively regulating mTOR activity via the small GTP-binding protein Rheb. TSC1 is also called hamartin, LAM, TSC, KIAA0243, and MGC86987.

Rabbit IgG SR: human, mouse
Immunogen: synthetic peptide. The epitope recognized by A300-316A maps to a region between residue 1100 and the C-terminus (residue 1164) of human tuberous sclerosis 1 using the numbering given in Swiss-Prot entry Q92574 (GeneID 7248).
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A301-812A
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Cyclin-dependent kinase 2 (CDK2) is a member of the CDK family of protein kinases that regulate cell cycle progression. CDK2 associates with cyclin E or cyclin A to drive the cell cycle through G1- and S-phase. Substrates of CDK2 include pRb, p53, p27, E2F, Brca1, CDK7, B-Myb, PP1 alpha, RNA Pol II CTD, axin, p220 NPAT, ribonucleotide reductase M2, Myo-D, MARCKS, HsCdc6, and CP110. Alternate names for CDK2 include cell division protein kinase 2, and p33 protein kinase.

Rabbit IgG SR: human
Immunogen: synthetic peptide. The epitope recognized by A301-812A maps to a region between residue 248 and 298 of human cyclin-dependent kinase 2 using the numbering given in entry NP_001789.2 (GeneID 1017).
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IHC-00374
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Cyclin-dependent kinase 2 (CDK2) is a member of the CDK family of protein kinases that regulate cell cycle progression. CDK2 associates with cyclin E or cyclin A to drive the cell cycle through G1- and S-phase. Substrates of CDK2 include pRb, p53, p27, E2F, Brca1, CDK7, B-Myb, PP1 alpha, RNA Pol II CTD, axin, p220 NPAT, ribonucleotide reductase M2, Myo-D, MARCKS, HsCdc6, and CP110. Alternate names for CDK2 include cell division protein kinase 2, and p33 protein kinase.

Rabbit IgG SR: human, mouse
Immunogen: synthetic peptide. The epitope recognized by IHC-00374 maps to a region between residue 248 and 298 of human cyclin-dependent kinase 2 using the numbering given in entry NP_001789.2 (GeneID 1017).
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A304-196A
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Protein function: Polycomb group (PcG) protein. Catalytic subunit of the PRC2/EED-EZH2 complex, which methylates 'Lys-9' (H3K9me) and 'Lys- 27' (H3K27me) of histone H3, leading to transcriptional repression of the affected target gene. Able to mono-, di- and trimethylate 'Lys-27' of histone H3 to form H3K27me1, H3K27me2 and H3K27me3, respectively. Compared to EZH2-containing complexes, it is more abundant in embryonic stem cells and plays a major role in forming H3K27me3, which is required for embryonic stem cell identity and proper differentiation. The PRC2/EED-EZH2 complex may also serve as a recruiting platform for DNA methyltransferases, thereby linking two epigenetic repression systems. Genes repressed by the PRC2/EED-EZH2 complex include HOXC8, HOXA9, MYT1, CDKN2A and retinoic acid target genes. EZH2 can also methylate non-histone proteins such as the transcription factor GATA4 and the nuclear receptor RORA. [The UniProt Consortium]

Rabbit IgG SR: human
Immunogen: synthetic peptide. The epitope recognized by A304-196A maps to a region between residue 175 to 225 of human Enhancer of Zeste Homolog 2 using the numbering given in entry CAA64955.1 (GeneID 2146).
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A304-197A
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Protein function: Polycomb group (PcG) protein. Catalytic subunit of the PRC2/EED-EZH2 complex, which methylates 'Lys-9' (H3K9me) and 'Lys- 27' (H3K27me) of histone H3, leading to transcriptional repression of the affected target gene. Able to mono-, di- and trimethylate 'Lys-27' of histone H3 to form H3K27me1, H3K27me2 and H3K27me3, respectively. Compared to EZH2-containing complexes, it is more abundant in embryonic stem cells and plays a major role in forming H3K27me3, which is required for embryonic stem cell identity and proper differentiation. The PRC2/EED-EZH2 complex may also serve as a recruiting platform for DNA methyltransferases, thereby linking two epigenetic repression systems. Genes repressed by the PRC2/EED-EZH2 complex include HOXC8, HOXA9, MYT1, CDKN2A and retinoic acid target genes. EZH2 can also methylate non-histone proteins such as the transcription factor GATA4 and the nuclear receptor RORA. [The UniProt Consortium]

Rabbit IgG SR: human, mouse
Immunogen: synthetic peptide. The epitope recognized by A304-197A maps to a region between residue 696 to 746 of human Enhancer of Zeste Homolog 2 using the numbering given in entry CAA64955.1 (GeneID 2146).
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A311-507A
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1 each of A304-196A and A304-197A

Rabbit IgG SR: human, mouse
Immunogen: synthetic peptide. Antibodies were affinity purified using epitopes specific to EZH2 immobilized on solid support.
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IHC-00388
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EZH2 is a polycomb group enzyme that functions to methylate histone H3-lysine 27 and mediate gene silencing of Homeobox (Hox) genes during development. EZH2 possesses a SET domain which is important to methyltransferase activity. Amplification of EZH2 has been reported in a number of malignancies and may contribute to oncogenesis. Alternate names for EZH2 include enhancer of zeste homolog 2, ENX-1, and MGC9169.

Rabbit IgG SR: human, mouse
Immunogen: synthetic peptide. The epitope recognized by IHC-00388 maps to phosphorylated Serine 21 and surrounding residues of human Enhancer of Zeste homolog 2 using the numbering given in entry NP_004447.2 (GeneID 2146).
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A302-958A
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c-Jun is a transcription factor that heterodimerizes with FOS to form the activator protein 1 (AP-1) transcription factor. The JUN gene is the putative transforming gene of avian sarcoma virus 17. Alternate names for c-Jun include activator protein 1, transcription factor AP-1, AP1, proto-oncogene c-Jun, V-jun avian sarcoma virus 17 oncogene homolog, p39.

Rabbit IgG SR: human, mouse
Immunogen: synthetic peptide. The epitope recognized by A302-958A maps to a region between residue 1 and 40 of human Jun Oncogene using the numbering given in entry NP_002219.1 (GeneID 3725).
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A302-959A
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c-Jun is a transcription factor that heterodimerizes with FOS to form the activator protein 1 (AP-1) transcription factor. The JUN gene is the putative transforming gene of avian sarcoma virus 17. Alternate names for c-Jun include activator protein 1, transcription factor AP-1, AP1, proto-oncogene c-Jun, V-jun avian sarcoma virus 17 oncogene homolog, p39.

Rabbit IgG SR: human, mouse
Immunogen: synthetic peptide. The epitope recognized by A302-959A maps to a region between residue 40 and 80 of human Jun Oncogene using the numbering given in entry NP_002219.1 (GeneID 3725).
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A311-097A
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1 each of A302-958A and A302-959A

Rabbit IgG SR: human, mouse
Immunogen: synthetic peptide.
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A300-358A
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By sequence similarity p300 is related to CBP (CREB-binding protein) and functions as a histone acetyltransferase that can regulate transcription by influencing chromatin organization. P300 has been demonstrated to bind to phosphorylated CREB to mediate cAMP-gene regulation. P300 has also been identified as a co-activator of HIF1A (hypoxia-inducible factor 1 alpha). Alternate names for p300 include histone acetyltransferase p300, E1A-associated protein p300, and EP300.

Rabbit IgG SR: human
Immunogen: synthetic peptide. The epitope recognized by A300-358A maps to a region between residues 950 and 1000 of human E1A-associated protein p300 using the numbering given in entry NP_001420.2 (GeneID 2033).
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A300-359A
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By sequence similarity p300 is related to CBP (CREB-binding protein) and functions as a histone acetyltransferase that can regulate transcription by influencing chromatin organization. P300 has been demonstrated to bind to phosphorylated CREB to mediate cAMP-gene regulation. P300 has also been identified as a co-activator of HIF1A (hypoxia-inducible factor 1 alpha). Alternate names for p300 include histone acetyltransferase p300, E1A-associated protein p300, and EP300.

Rabbit IgG SR: human
Immunogen: synthetic peptide. The epitope recognized by A300-359A maps to a region between residues 1000 and 1050 of human E1A-associated protein p300 using the numbering given in entry NP_001420.2 (GeneID 2033).
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A310-097A
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Antibodies were affinity purified using epitopes specific to p300 immobilized on solid support.

Rabbit IgG SR: human
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IHC-00028
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By sequence similarity p300 is related to CBP (CREB-binding protein) and functions as a histone acetyltransferase that can regulate transcription by influencing chromatin organization. P300 has been demonstrated to bind to phosphorylated CREB to mediate cAMP-gene regulation. P300 has also been identified as a co-activator of HIF1A (hypoxia-inducible factor 1 alpha). Alternate names for p300 include histone acetyltransferase p300, E1A-associated protein p300, and EP300.

Rabbit IgG SR: human
Immunogen: synthetic peptide. The epitope recognized by IHC-00028 maps to a region between residue 950 and 1000 of human 1A-associated protein p300 using the numbering given in entry NP_001420.2 (GeneID 2033).
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A302-384A
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BAD (Bcl2 agonist of cell death) is a member of the Bcl-2 family. Bcl-2 family members are known to be regulators of programmed cell death. This protein positively regulates cell apoptosis by forming heterodimers with Bcl-xL and Bcl-2, and reversing their death repressor activity. Proapoptotic activity of this protein is regulated through its phosphorylation. Protein kinases AKT and MAP kinase, as well as protein phosphatase calcineurin were found to be involved in the regulation of this protein. Alternate names for BAD include Bcl-2 binding component 6, Bcl-2-like protein 8, Bcl2-L-8, Bcl-Xl/Bcl-2-associated death promoter, BBC6, and BCL2L8.

Rabbit IgG SR: human
Immunogen: synthetic peptide. The epitope recognized by A302-384A maps to a region between residue 1 and 50 of human BCL2-antagonist of cell death using the numbering given in entry NP_004313.1 (GeneID 572).
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IHC-00677
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BAD (Bcl2 agonist of cell death) is a member of the Bcl-2 family. Bcl-2 family members are known to be regulators of programmed cell death. This protein positively regulates cell apoptosis by forming heterodimers with Bcl-xL and Bcl-2, and reversing their death repressor activity. Proapoptotic activity of this protein is regulated through its phosphorylation. Protein kinases AKT and MAP kinase, as well as protein phosphatase calcineurin were found to be involved in the regulation of this protein. Alternate names for BAD include Bcl-2 binding component 6, Bcl-2-like protein 8, Bcl2-L-8, Bcl-Xl/Bcl-2-associated death promoter, BBC6, and BCL2L8. [taken from NCBI Entrez Gene (GeneID:572)]

Rabbit IgG SR: human, mouse
Immunogen: synthetic peptide. The epitope recognized by IHC-00677 maps to a region between residue 1 and 50 of human BCL2-antagonist of cell death using the numbering given in entry NP_004313.1 (GeneID 572).
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A300-516A
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DNA-PKcs is the catalytic subunit of a DNA-dependent serine-threonine protein kinase (DNA-PK). DNA-PK is a heterotrimer comprised of DNA-PKcs and the Ku709/Ku86 dimer. DNA-PK is involved in DNA damage repair and V(D)J recombination. DNA-PK phosphorylates Artemis, a protein required for nonhomologous end-joining and is necessary for the loading of Artemis on damaged DNA. Alternate names for DNA-PKcs include DNA-dependent protein kinase catalytic subunit, DNA-PK catalytic subunit, DNPK1, p460, PRKDC, HYRC, HYRC1, and XRCC7.

Rabbit IgG SR: human
Immunogen: synthetic peptide. The epitope recognized by A300-516A maps to a region between residues 1850 and 1900 of human DNA-Dependent Protein Kinase, catalytic subunit using the numbering given in entry NP_008835.5 (GeneID 5591).
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A300-517A
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DNA-PKcs is the catalytic subunit of a DNA-dependent serine-threonine protein kinase (DNA-PK). DNA-PK is a heterotrimer comprised of DNA-PKcs and the Ku709/Ku86 dimer. DNA-PK is involved in DNA damage repair and V(D)J recombination. DNA-PK phosphorylates Artemis, a protein required for nonhomologous end-joining and is necessary for the loading of Artemis on damaged DNA. Alternate names for DNA-PKcs include DNA-dependent protein kinase catalytic subunit, DNA-PK catalytic subunit, DNPK1, p460, PRKDC, HYRC, HYRC1, and XRCC7.

Rabbit IgG SR: human
Immunogen: synthetic peptide. The epitope recognized by A300-517A maps to a region between residues 2050 and 2100 of human DNA-Dependent Protein Kinase, catalytic subunit using the numbering given in entry NP_008835.5 (GeneID 5591).
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A300-518A
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DNA-PKcs is the catalytic subunit of a DNA-dependent serine-threonine protein kinase (DNA-PK). DNA-PK is a heterotrimer comprised of DNA-PKcs and the Ku709/Ku86 dimer. DNA-PK is involved in DNA damage repair and V(D)J recombination. DNA-PK phosphorylates Artemis, a protein required for nonhomologous end-joining and is necessary for the loading of Artemis on damaged DNA. Alternate names for DNA-PKcs include DNA-dependent protein kinase catalytic subunit, DNA-PK catalytic subunit, DNPK1, p460, PRKDC, HYRC, HYRC1, and XRCC7.

Rabbit IgG SR: human
Immunogen: synthetic peptide. The epitope recognized by A300-518A maps to a region between residues 2100 and 2150 of human DNA-Dependent Protein Kinase, catalytic subunit using the numbering given in entry NP_008835.5 (GeneID 5591).
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A300-519A
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DNA-PKcs is the catalytic subunit of a DNA-dependent serine-threonine protein kinase (DNA-PK). DNA-PK is a heterotrimer comprised of DNA-PKcs and the Ku709/Ku86 dimer. DNA-PK is involved in DNA damage repair and V(D)J recombination. DNA-PK phosphorylates Artemis, a protein required for nonhomologous end-joining and is necessary for the loading of Artemis on damaged DNA. Alternate names for DNA-PKcs include DNA-dependent protein kinase catalytic subunit, DNA-PK catalytic subunit, DNPK1, p460, PRKDC, HYRC, HYRC1, and XRCC7.

Rabbit IgG SR: human
Immunogen: synthetic peptide. The epitope recognized by A300-519A maps to a region between residue 4075 and the C-terminus (residue 4128) of human DNA-Dependent Protein Kinase, catalytic subunit using the numbering given in entry NP_008835.5 (GeneID 5591).
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A303-967A
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DNA-PKcs is the catalytic subunit of a DNA-dependent serine-threonine protein kinase (DNA-PK). DNA-PK is a heterotrimer comprised of DNA-PKcs and the Ku709/Ku86 dimer. DNA-PK is involved in DNA damage repair and V(D)J recombination. DNA-PK phosphorylates Artemis, a protein required for nonhomologous end-joining and is necessary for the loading of Artemis on damaged DNA.

Goat IgG SR: human
Immunogen: synthetic peptide. The epitope recognized by A303-967A maps to a region between residue 4078 to 4128 of human Protein Kinase, DNA-Activated, Catalytic Polypeptide using the numbering given in entry NP_008835.5 (GeneID 5591).
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A310-147A
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Antibodies were affinity purified using epitopes specific to DNA-PKcs immobilized on solid support.

Rabbit IgG SR: human
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IHC-00044
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DNA-PKcs is the catalytic subunit of a DNA-dependent serine-threonine protein kinase (DNA-PK). DNA-PK is a heterotrimer comprised of DNA-PKcs and the Ku709/Ku86 dimer. DNA-PK is involved in DNA damage repair and V(D)J recombination. DNA-PK phosphorylates Artemis, a protein required for nonhomologous end-joining and is necessary for the loading of Artemis on damaged DNA. Alternate names for DNA-PKcs include DNA-dependent protein kinase catalytic subunit, DNA-PK catalytic subunit, DNPK1, p460, PRKDC, HYRC, HYRC1, and XRCC7.

Rabbit IgG SR: human
Immunogen: synthetic peptide. The epitope recognized by IHC-00044 maps to a region between residue 2100 and 2150 of human DNA-Dependent Protein Kinase, catalytic subunit using the numbering given in entry NP_008835.5 (GeneID 5591).
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A300-362A
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CBP [cAMP response element-binding protein (CREB)-binding protein] interacts with and is a transcriptional co-activator of a multitude of transcriptional regulators that includes CREB. CBP is structurally and functionally similar to p300 but is encoded by an independent gene. CBP coactivation may be achieved through the regulation of chromatin structure due to its ability to catalyze the acetylation of histones. CBP has potential tumor suppressor properties and is important to integrating cell-signaling cues for proliferation, differentiation and apoptosis. CBP is also known as CREB-binding protein, CREBBP, RTS, and RSTS.

Rabbit IgG SR: human
Immunogen: synthetic peptide. The epitope recognized by A300-362A maps to a region between residues 975 and 1025 of human CREB Binding Protein using the numbering given in entry NP_004371.1 (GeneID 1387).
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A300-363A
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CBP [cAMP response element-binding protein (CREB)-binding protein] interacts with and is a transcriptional co-activator of a multitude of transcriptional regulators that includes CREB. CBP is structurally and functionally similar to p300 but is encoded by an independent gene. CBP coactivation may be achieved through the regulation of chromatin structure due to its ability to catalyze the acetylation of histones. CBP has potential tumor suppressor properties and is important to integrating cell-signaling cues for proliferation, differentiation and apoptosis. CBP is also known as CREB-binding protein, CREBBP, RTS, and RSTS.

Rabbit IgG SR: human
Immunogen: synthetic peptide. The epitope recognized by A300-363A maps to a region between residues 2375 and 2425 of human CREB Binding Protein using the numbering given in entry NP_004371.1 (GeneID 1387).
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A310-098A
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Antibodies were affinity purified using epitopes specific to CBP immobilized on solid support.

Rabbit IgG SR: human
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IHC-00023
IHC Erklärungen der Abkürzungen ansehen.
CBP [cAMP response element-binding protein (CREB)-binding protein] interacts with and is a transcriptional co-activator of a multitude of transcriptional regulators that includes CREB. CBP is structurally and functionally similar to p300 but is encoded by an independent gene. CBP coactivation may be achieved through the regulation of chromatin structure due to its ability to catalyze the acetylation of histones. CBP has potential tumor suppressor properties and is important to integrating cell-signaling cues for proliferation, differentiation and apoptosis. CBP is also known as CREB-binding protein, CREBBP, RTS, and RSTS.

Rabbit IgG SR: human
Immunogen: synthetic peptide. The epitope recognized by IHC-00023 maps to a region between residue 2375 and 2425 of human CREB Binding Protein using the numbering given in entry NP_004371.11 (GeneID 1387).
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A302-752A
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STAT1 (signal transducer and activator of transcription 1) is a member of the STAT protein family). In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. STAT1 can be activated by various ligands including interferon-alpha, interferon-gamma, EGF, PDGF and IL6. This protein mediates the expression of a variety of genes, which is thought to be important for cell viability in response to different cell stimuli and pathogens. Alternative names for STAT1 include ISGF-3, STAT91, signal transducer and activator of transcription 1-alpha/beta, and Transcription factor ISGF-3 components p91/p84. [taken from NCBI Entrez Gene (GeneID: 6772)]

Rabbit IgG SR: human
Immunogen: synthetic peptide. The epitope recognized by A302-752A maps to a region between residue 175 and 225 of human Signal Transducer and Activator of Transcription 1 using the numbering given in entry NP_009330.1 (GeneID 6772).
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A302-753A
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STAT1 (signal transducer and activator of transcription 1) is a member of the STAT protein family). In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. STAT1 can be activated by various ligands including interferon-alpha, interferon-gamma, EGF, PDGF and IL6. This protein mediates the expression of a variety of genes, which is thought to be important for cell viability in response to different cell stimuli and pathogens. Alternative names for STAT1 include ISGF-3, STAT91, signal transducer and activator of transcription 1-alpha/beta, and Transcription factor ISGF-3 components p91/p84. [taken from NCBI Entrez Gene (GeneID: 6772)]

Rabbit IgG SR: human, mouse
Immunogen: synthetic peptide. The epitope recognized by A302-753A maps to a region between residue 700 and 750 of human Signal Transducer and Activator of Transcription 1 using the numbering given in entry NP_009330.1 (GeneID 6772).
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A311-007A
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1 each of A302-752A and A302-753A

Rabbit IgG SR: human, mouse
Immunogen: synthetic peptide
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A302-209A
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AKT2 is one of 3 highly homologous serine/threonine kinases which include AKT1, AKT2, and AKT3. AKT2 has been found play an integral role in the insulin signaling pathway and is implicated in cancer development. Alternative names for AKT2 include RAC-beta serine/threonine-protein kinase, RAC-PK-beta, protein kinase B beta, and PKB beta.

Rabbit IgG SR: human
Immunogen: synthetic peptide. The epitope recognized by A302-209A maps to a region between residue 431 and 481 of human v-akt murine thymoma viral oncogene homolog 2 using the numbering given in entry NP_001617.1 (GeneID 208).
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S302-209
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Rabbit anti-AKT2 affinity purified antibodies were coupled to agarose beads using a cyanogen bromide method.

Rabbit IgG SR: human
Immunogen: synthetic peptide
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A301-620A
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Vimentin is an intermediate filament expressed mainly in mesenchymal tissue and in primitive (undifferentiated) non-mesenchymal cells. It is a Class III cytoplasmic filament that forms a dense cytoskeletal network that extends from the nucleus to the plasma membrane. Vimentin reorganization during mitosis is likely regulated via its multiple phosphorylation sites. Vimentin expression is also found in mesoderm derived epithelia. Immunohistochemistry (IHC) with anti-vimentin antibodies is often used to identify neoplasms of mesenchymal or mesodermal origin.

Rabbit IgG SR: human, mouse
Immunogen: synthetic peptide. The epitope recognized by A301-620A maps to a region between residue 416 and 466 of human vimentin using the numbering given in entry NP_003371.2 (GeneID 7431).
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IHC-00314
IHC, IHC-​IF Erklärungen der Abkürzungen ansehen.
Vimentin is an intermediate filament expressed mainly in mesenchymal tissue and in primitive (undifferentiated) non-mesenchymal cells. It is a Class III cytoplasmic filament that forms a dense cytoskeletal network that extends from the nucleus to the plasma membrane. Vimentin reorganization during mitosis is likely regulated via its multiple phosphorylation sites. Vimentin expression is also found in mesoderm derived epithelia. Immunohistochemistry (IHC) with anti-vimentin antibodies is often used to identify neoplasms of mesenchymal or mesodermal origin.

Rabbit IgG SR: human
Immunogen: synthetic peptide. The epitope recognized by IHC-00314 maps to a region between residue 416 and 466 of human vimentin using the numbering given in entry NP_003371.2 (GeneID 7431).
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A302-061A
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Extracellular signal-regulated kinase 2 (ERK2/p42) is also known as mitogen-activated protein kinase 1 (MAPK1). ERK2 is part of a signal transduction pathway that begins with the small GTPase Ras and continues through a cascade of protein kinases that include Raf and MEK. Activation of this signaling pathway influences many cellular processes such as proliferation, differentiation and survival. ERK2 is very similar in sequence to ERK1/p44 and the activities of both ERK1 and ERK2 are usually considered together as total ERK activity. More recent evidence has shown that ERK1 and ERK2 are not functionally redundant and may have very different and specific roles. Alternative names for ERK2 include p42-MAPK, ERT1, MAPK2, PRKM1, and PRKM2.

Rabbit IgG SR: human
Immunogen: synthetic peptide. The epitope recognized by A302-061A maps to a region between residue 310 and 360 of human extracellular signal-regulated kinase-2 (mitogen-activated protein kinase 1) using the numbering given in entry NP_002736.3 (GeneID 5594).
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IHC-00506
IHC Erklärungen der Abkürzungen ansehen.
Extracellular signal-regulated kinase 2 (ERK2/p42) is also known as mitogen-activated protein kinase 1 (MAPK1). ERK2 is part of a signal transduction pathway that begins with the small GTPase Ras and continues through a cascade of protein kinases that include Raf and MEK. Activation of this signaling pathway influences many cellular processes such as proliferation, differentiation and survival. ERK2 is very similar in sequence to ERK1/p44 and the activities of both ERK1 and ERK2 are usually considered together as total ERK activity. More recent evidence has shown that ERK1 and ERK2 are not functionally redundant and may have very different and specific roles. Alternative names for ERK2 include p42-MAPK, ERT1, MAPK2, PRKM1, and PRKM2.

Rabbit IgG SR: human
Immunogen: synthetic peptide. The epitope recognized by IHC-00506 maps to a region between residue 310 and 360 of human extracellular signal-regulated kinase-2 (mitogen-activated protein kinase 1) using the numbering given in entry NP_002736.3 (GeneID 5594).
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A300-510A
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70 kDa ribosomal protein S6 kinase I (p70S6K) encodes a member of the ribosomal S6 kinase family that phosphorylates the 40 S ribosomal subunit protein S6 and eukaryotic translation initiation factor 4B (eIF4B). p70S6 functions in the PI3K and mTOR pathway to induce protein synthesis and cell growth and proliferation in response to growth factors. S6K2 is an isoform of p70S6K. p70S6K is also called S6K, PS6K, S6K1, STK14A, p70-S6K, p70-alpha, p70 (S6K)-alpha, ribosomal protein S6 kinase beta 1, RPS6B1.

Rabbit IgG SR: rat
Immunogen: synthetic peptide. The epitope recognized by A300-510A maps to a region between residue 475 and the C-terminus (residue 525) of human Ribosomal Protein S6 Kinase, 70 kDa, polypeptide 1 using the numbering given in entry NP_003152.1 (GeneID 6198).
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A303-675A
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B-cell CLL/lymphoma 2 (Bcl-2) is an integral outer mitochondrial membrane protein that blocks the apoptotic death of some cells such as lymphocytes. Constitutive expression of Bcl-2, such as in the case of translocation of Bcl-2 to Ig heavy chain locus, is thought to be the cause of follicular lymphoma. [taken from NCBI Entrez Gene (Gene ID: 596)]

Rabbit IgG SR: human
Immunogen: Synthetic peptide. The epitope recognized by A303-675A maps to a region between residue 50 and 100 of human B-cell CLL/lymphoma 2 using the numbering given in entry NP_000624.2 (GeneID 596).
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A300-503A
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Studies of the mammalian target of rapamycin (mTOR) and its homologs demonstrate a role in integrating signals from growth factors, nutrients, stress, and cellular energy levels to control cell growth, translation initiation, ribosome biogenesis, and transcription factor localization. mTOR is the direct target of the cell cycle arresting activity of rapamycin. mTOR interacts with Raptor or Rictor to form the mTORC1 and mTORC2 complexes respectively. The mTORC1 complex also includes mLst8/GbetaL and functions to phosphorylate S6K and 4EBP1. The mTORC2 complex also includes mLst8/GbetaL, mSIN1 and protor-1 and functions to phosphorylate Akt. mTOR is also known as FKBP12-rapamycin complex-associated protein, FK506-binding protein 12-rapamycin complex-associated protein 1, rapamycin target protein, FRAP, FRAP1, FRAP2, RAFT1, RAPT1, and FLJ44809.

Rabbit IgG SR: human, rat
Immunogen: synthetic peptide. The epitope recognized by A300-503A maps to a region between residue 200 and 250 of human Mammalian Target of Rapamycin using the numbering given in entry NP_004949.1 (GeneID 2475).
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A300-504A
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Studies of the mammalian target of rapamycin (mTOR) and its homologs demonstrate a role in integrating signals from growth factors, nutrients, stress, and cellular energy levels to control cell growth, translation initiation, ribosome biogenesis, and transcription factor localization. mTOR is the direct target of the cell cycle arresting activity of rapamycin. mTOR interacts with Raptor or Rictor to form the mTORC1 and mTORC2 complexes respectively. The mTORC1 complex also includes mLst8/GbetaL and functions to phosphorylate S6K and 4EBP1. The mTORC2 complex also includes mLst8/GbetaL, mSIN1 and protor-1 and functions to phosphorylate Akt. mTOR is also known as FKBP12-rapamycin complex-associated protein, FK506-binding protein 12-rapamycin complex-associated protein 1, rapamycin target protein, FRAP, FRAP1, FRAP2, RAFT1, RAPT1, and FLJ44809.

Rabbit IgG SR: human, rat, mouse
Immunogen: synthetic peptide. The epitope recognized by A300-504A maps to a region between residue 200 and 250 of human Mammalian Target of Rapamycin using the numbering given in entry NP_004949.1 (GeneID 2475).
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A301-142A
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Studies of the mammalian target of rapamycin (mTOR) and its homologs demonstrate a role in integrating signals from growth factors, nutrients, stress, and cellular energy levels to control cell growth, translation initiation, ribosome biogenesis, and transcription factor localization. mTOR is the direct target of the cell cycle arresting activity of rapamycin. mTOR interacts with Raptor or Rictor to form the mTORC1 and mTORC2 complexes respectively. The mTORC1 complex also includes mLst8/GbetaL and functions to phosphorylate S6K and 4EBP1. The mTORC2 complex also includes mLst8/GbetaL, mSIN1 and protor-1 and functions to phosphorylate Akt. mTOR is also known as FKBP12-rapamycin complex-associated protein, FK506-binding protein 12-rapamycin complex-associated protein 1, rapamycin target protein, FRAP, FRAP1, FRAP2, RAFT1, RAPT1, and FLJ44809.

Rabbit IgG SR: human, mouse
Immunogen: synthetic peptide. The epitope recognized by A301-142A maps to a region between residue 1125 and 1175 of human mammalian target of rapamycin using the numbering given in entry NP_004949.1 (GeneID 2475).
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A301-143A
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WB, IP Erklärungen der Abkürzungen ansehen.
Studies of the mammalian target of rapamycin (mTOR) and its homologs demonstrate a role in integrating signals from growth factors, nutrients, stress, and cellular energy levels to control cell growth, translation initiation, ribosome biogenesis, and transcription factor localization. mTOR is the direct target of the cell cycle arresting activity of rapamycin. mTOR interacts with Raptor or Rictor to form the mTORC1 and mTORC2 complexes respectively. The mTORC1 complex also includes mLst8/GbetaL and functions to phosphorylate S6K and 4EBP1. The mTORC2 complex also includes mLst8/GbetaL, mSIN1 and protor-1 and functions to phosphorylate Akt. mTOR is also known as FKBP12-rapamycin complex-associated protein, FK506-binding protein 12-rapamycin complex-associated protein 1, rapamycin target protein, FRAP, FRAP1, FRAP2, RAFT1, RAPT1, and FLJ44809.

Rabbit IgG SR: human, mouse
Immunogen: synthetic peptide. The epitope recognized by A301-143A maps to a region between residue 1350 and 1400 of human mammalian target of rapamycin using the numbering given in entry NP_004949.1 (GeneID 2475).
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A301-144A
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WB, IP Erklärungen der Abkürzungen ansehen.
Studies of the mammalian target of rapamycin (mTOR) and its homologs demonstrate a role in integrating signals from growth factors, nutrients, stress, and cellular energy levels to control cell growth, translation initiation, ribosome biogenesis, and transcription factor localization. mTOR is the direct target of the cell cycle arresting activity of rapamycin. mTOR interacts with Raptor or Rictor to form the mTORC1 and mTORC2 complexes respectively. The mTORC1 complex also includes mLst8/GbetaL and functions to phosphorylate S6K and 4EBP1. The mTORC2 complex also includes mLst8/GbetaL, mSIN1 and protor-1 and functions to phosphorylate Akt. mTOR is also known as FKBP12-rapamycin complex-associated protein, FK506-binding protein 12-rapamycin complex-associated protein 1, rapamycin target protein, FRAP, FRAP1, FRAP2, RAFT1, RAPT1, and FLJ44809.

Rabbit IgG SR: human
Immunogen: synthetic peptide. The epitope recognized by A301-144A maps to a region between residue 1675 and 1725 of human mammalian target of rapamycin using the numbering given in entry NP_004949.1 (GeneID 2475).
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A310-114A
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Antibodies were affinity purified using epitopes specific to mTOR immobilized on solid support.

Rabbit IgG SR: human, mouse, rat
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A310-378A
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Antibodies were affinity purified using epitopes specific to mTOR immobilized on solid support.

Rabbit IgG SR: human, mouse
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S300-503
IP Erklärungen der Abkürzungen ansehen.
Rabbit anti-human mTOR affinity purified Antibodies were coupled to agarose beads using a cyanogen bromide method.

Rabbit IgG SR: human, rat
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S300-504
IP Erklärungen der Abkürzungen ansehen.
Rabbit anti-human mTOR affinity purified Antibodies were coupled to agarose beads using a cyanogen bromide method.

Rabbit IgG SR: human, rat
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S301-144
IP Erklärungen der Abkürzungen ansehen.
Rabbit anti-mTOR affinity purified antibodies were coupled to agarose beads using a cyanogen bromide method.

Rabbit IgG SR: human
Immunogen: synthetic peptide
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A301-819A
IP, PLA Erklärungen der Abkürzungen ansehen.
The NFKB1 gene encodes a 105 kDa protein that can undergo co-translational processing to also yield a 50 kDa protein. The 50 kDa protein is also known as NF-kappa B1/p50 and is one of five monomeric subunits that are part of the Rel family of proteins that dimerize to form the NF-kappa B (nuclear factor that binds the kappa immunoglobulin light chain gene enhancer) transcription factor. Members of the Rel family of proteins include NF-kappa B1/p50, NF-kappa B2/p52, RelA/p65, c-Rel, and RelB. The 105 kDa product is also known as p105 or I kappa B gamma. p105/I kappa B gamma has been shown to function as an inhibitor protein that interacts with NF-kappa B and inhibit its DNA binding activity. p105/I kappa B gamma is a member of the I kappa B family of proteins which includes I kappa B-beta, I kappa B-delta/NF-kappa B2/p100, I kappa B-gamma/NF-kappa B1/p105, I kappa B-epsilon, I kappa B-zeta, and Bcl3. The classical description of the NF-kappa B transcription factor is a transcription factor that reprograms gene expression of the immune system in response to injury, infection, and stress. Alternative names for NF-kappa B1 include nuclear factor NF-kappa-B p50 subunit, NF-kappa-B p105, EBP-1, DNA-binding factor KBF1, NFKB1, NFKB-p105, and NFKB-p50.

Rabbit IgG SR: human
Immunogen: synthetic peptide. The epitope recognized by A301-819A maps to a region between residue 1 and 50 of human nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105) using the numbering given in entry AAF35232.1 (GeneID 4790).
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A301-820A
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The NFKB1 gene encodes a 105 kDa protein that can undergo co-translational processing to also yield a 50 kDa protein. The 50 kDa protein is also known as NF-kappa B1/p50 and is one of five monomeric subunits that are part of the Rel family of proteins that dimerize to form the NF-kappa B (nuclear factor that binds the kappa immunoglobulin light chain gene enhancer) transcription factor. Members of the Rel family of proteins include NF-kappa B1/p50, NF-kappa B2/p52, RelA/p65, c-Rel, and RelB. The 105 kDa product is also known as p105 or I kappa B gamma. p105/I kappa B gamma has been shown to function as an inhibitor protein that interacts with NF-kappa B and inhibit its DNA binding activity. p105/I kappa B gamma is a member of the I kappa B family of proteins which includes I kappa B-beta, I kappa B-delta/NF-kappa B2/p100, I kappa B-gamma/NF-kappa B1/p105, I kappa B-epsilon, I kappa B-zeta, and Bcl3. The classical description of the NF-kappa B transcription factor is a transcription factor that reprograms gene expression of the immune system in response to injury, infection, and stress. Alternative names for NF-kappa B1 include nuclear factor NF-kappa-B p50 subunit, NF-kappa-B p105, EBP-1, DNA-binding factor KBF1, NFKB1, NFKB-p105, and NFKB-p50.

Rabbit IgG SR: human
Immunogen: synthetic peptide. The epitope recognized by A301-820A maps to a region between residue 918 and 968 of human nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105) using the numbering given in entry AAF35232.1 (GeneID 4790).
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A310-648A
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1 each of A301-819A and A301-820A

Rabbit IgG SR: human
Immunogen: synthetic peptide
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IHC-00518
IHC Erklärungen der Abkürzungen ansehen.
The NFKB1 gene encodes a 105 kDa protein that can undergo co-translational processing to also yield a 50 kDa protein. The 50 kDa protein is also known as NF-kappa B1/p50 and is one of five monomeric subunits that are part of the Rel family of proteins that dimerize to form the NF-kappa B (nuclear factor that binds the kappa immunoglobulin light chain gene enhancer) transcription factor. Members of the Rel family of proteins include NF-kappa B1/p50, NF-kappa B2/p52, RelA/p65, c-Rel, and RelB. The 105 kDa product is also known as p105 or I kappa B gamma. p105/I kappa B gamma has been shown to function as an inhibitor protein that interacts with NF-kappa B and inhibit its DNA binding activity. p105/I kappa B gamma is a member of the I kappa B family of proteins which includes I kappa B-beta, I kappa B-delta/NF-kappa B2/p100, I kappa B-gamma/NF-kappa B1/p105, I kappa B-epsilon, I kappa B-zeta, and Bcl3. The classical description of the NF-kappa B transcription factor is a transcription factor that reprograms gene expression of the immune system in response to injury, infection, and stress. Alternative names for NF-kappa B1 include nuclear factor NF-kappa-B p50 subunit, NF-kappa-B p105, EBP-1, DNA-binding factor KBF1, NFKB1, NFKB-p105, and NFKB-p50.

Rabbit SR: human
Immunogen: synthetic peptide. The epitope recognized by IHC-00518 maps to a region between residue 918 and 968 of human nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105) using the numbering given in entry AAF35232.1 (GeneID 4790).
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A302-048A
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Glycogen synthase kinase 3 beta (GSK3beta) is a proline-directed serine-threonine kinase identified as a kinase responsible for the phosphorylation and inactivation of glycogen synthase. GSK3beta is a critical component of the Wnt/beta-catenin signaling pathway, and its activity results in the inhibition of Wnt signaling by mediating the degradation of beta-catenin. In addition to the Wnt-signaling pathway, GSK3beta is also involved in the Hedgehog, Notch and insulin signaling pathways.

Rabbit IgG SR: human, mouse
Immunogen: synthetic peptide. The epitope recognized by A302-048A maps to a region between residue 370 and 420 of human glycogen synthase kinase-3 beta using the numbering given in entry AAA66475.1 (GeneID 2932).
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A302-049A
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Glycogen synthase kinase 3 beta (GSK3beta) is a proline-directed serine-threonine kinase identified as a kinase responsible for the phosphorylation and inactivation of glycogen synthase. GSK3beta is a critical component of the Wnt/beta-catenin signaling pathway, and its activity results in the inhibition of Wnt signaling by mediating the degradation of beta-catenin. In addition to the Wnt-signaling pathway, GSK3beta is also involved in the Hedgehog, Notch and insulin signaling pathways.

Rabbit IgG SR: human, mouse
Immunogen: synthetic peptide. The epitope recognized by A302-049A maps to a region between residue 1 and 50 of human glycogen synthase kinase-3 beta using the numbering given in entry AAA66475.1 (GeneID 2932).
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A310-723A
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1 each of A302-048A and A302-049A

Rabbit IgG SR: human, mouse
Immunogen: synthetic peptide
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A300-161A
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Chk1 functions as a checkpoint protein kinase that is critical to the regulation of the Cdc25a and Cdc25c phosphatases that promote S and G2/M phase progression, respectively. Chk1 kinase activity inhibits cell cycle progression in the presence of DNA damage by phosphorylating Cdc25a and Cdc25c and causing the degradation of Cdc25a and cytoplasmic sequestration of Cdc25c. Alternate designations for Chk1 include serine/threonine-protein kinase Chk1, and CHEK1.

Goat IgG SR: human
Immunogen: synthetic peptide. The epitope recognized by A300-161A maps to a region between residues 200 and 250 of human Checkpoint Kinase 1 using the numbering given in entry NP_001265.1 (GeneID 1111).
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A300-162A
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Chk1 functions as a checkpoint protein kinase that is critical to the regulation of the Cdc25a and Cdc25c phosphatases that promote S and G2/M phase progression, respectively. Chk1 kinase activity inhibits cell cycle progression in the presence of DNA damage by phosphorylating Cdc25a and Cdc25c and causing the degradation of Cdc25a and cytoplasmic sequestration of Cdc25c. Alternate designations for Chk1 include serine/threonine-protein kinase Chk1, and CHEK1.

Goat IgG SR: human
Immunogen: synthetic peptide. The epitope recognized by A300-162A maps to a region between residues 250 and 300 of human Checkpoint Kinase 1 using the numbering given in entry NP_001265.1 (GeneID 1111).
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A300-163A
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Chk1 functions as a checkpoint protein kinase that is critical to the regulation of the Cdc25a and Cdc25c phosphatases that promote S and G2/M phase progression, respectively. Chk1 kinase activity inhibits cell cycle progression in the presence of DNA damage by phosphorylating Cdc25a and Cdc25c and causing the degradation of Cdc25a and cytoplasmic sequestration of Cdc25c. Alternate designations for Chk1 include serine/threonine-protein kinase Chk1, and CHEK1.

Rabbit IgG SR: human
Immunogen: synthetic phospho-peptide. Immunogen for A300-163A was a phosphorylated synthetic peptide, which represented a portion of human Checkpoint Kinase 1 (GeneID 1111) around serine 317 according to the numbering given in entry NP_001265.1.
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A300-298A
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Chk1 functions as a checkpoint protein kinase that is critical to the regulation of the Cdc25a and Cdc25c phosphatases that promote S and G2/M phase progression, respectively. Chk1 kinase activity inhibits cell cycle progression in the presence of DNA damage by phosphorylating Cdc25a and Cdc25c and causing the degradation of Cdc25a and cytoplasmic sequestration of Cdc25c. Alternate designations for Chk1 include serine/threonine-protein kinase Chk1, and CHEK1.

Rabbit IgG SR: human
Immunogen: synthetic peptide. The epitope recognized by A300-298A maps to a region between residues 250 and 300 of human Checkpoint Kinase 1 using the numbering given in SwissProt entry O14757 (GeneID 1111).
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A310-044A
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Antibodies were affinity purified using epitopes specific to Chk1 immobilized on solid support.

Rabbit IgG SR: human
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IHC-00004
IHC Erklärungen der Abkürzungen ansehen.
Chk1 functions as a checkpoint protein kinase that is critical to the regulation of the Cdc25a and Cdc25c phosphatases that promote S and G2/M phase progression, respectively. Chk1 kinase activity inhibits cell cycle progression in the presence of DNA damage by phosphorylating Cdc25a and Cdc25c and causing the degradation of Cdc25a and cytoplasmic sequestration of Cdc25c. Alternate designations for Chk1 include serine/threonine-protein kinase Chk1, and CHEK1.

Rabbit IgG SR: human, mouse
Immunogen: synthetic peptide. The epitope recognized by IHC-00004 maps to a region between residue 250 and 300 of human Checkpoint Kinase 1 using the numbering given in SwissProt entry O14757 (GeneID 1111).
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IHC-00068
IHC, ICC Erklärungen der Abkürzungen ansehen.
Chk1 functions as a checkpoint protein kinase that is critical to the regulation of the Cdc25a and Cdc25c phosphatases that promote S and G2/M phase progression, respectively. Chk1 kinase activity inhibits cell cycle progression in the presence of DNA damage by phosphorylating Cdc25a and Cdc25c and causing the degradation of Cdc25a and cytoplasmic sequestration of Cdc25c. Alternate designations for Chk1 include serine/threonine-protein kinase Chk1, and CHEK1.

Rabbit IgG SR: human
Immunogen: synthetic peptide. Immunogen for IHC-0229P was a phosphorylated synthetic peptide, which represented a portion of human Checkpoint Kinase 1 around serine 317 according to the numbering given in entry NP_001265.1 (GeneID 1111).
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A302-139A
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MEK1 is an activator and kinase for MAP and ERK kinases. It is a serine/threonine kinase essential to the MAP kinase signal transduction pathway which is involved in a multitude of cellular processes such as proliferation, differentiation, gene activation, and development. MEK1 displays 85 percent identity with MEK2. Although MEK1 and MEK2 have been found to be functionally similar, they may serve non-redundant functions. Both are required for cellular proliferation and may play a role in tumorigenesis. Alternative names for MEK1 include dual specificity mitogen-activated protein kinase kinase 1, MAP kinase kinase 1, MAPKK1, ERK activator kinase 1, MAPK/ERK kinase 1, MEK1, MAP2K1, and PRKMK1.

Rabbit IgG SR: human
Immunogen: synthetic peptide. The epitope recognized by A302-139A maps to a region between residue 1 and 50 of human MAPK/ERK kinase 1 (Dual specificity mitogen-activated protein kinase kinase 1) using the numbering given in entry NP_002746.1 (GeneID 5604).
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A302-140A
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WB Erklärungen der Abkürzungen ansehen.
MEK1 is an activator and kinase for MAP and ERK kinases. It is a serine/threonine kinase essential to the MAP kinase signal transduction pathway which is involved in a multitude of cellular processes such as proliferation, differentiation, gene activation, and development. MEK1 displays 85 percent identity with MEK2. Although MEK1 and MEK2 have been found to be functionally similar, they may serve non-redundant functions. Both are required for cellular proliferation and may play a role in tumorigenesis. Alternative names for MEK1 include dual specificity mitogen-activated protein kinase kinase 1, MAP kinase kinase 1, MAPKK1, ERK activator kinase 1, MAPK/ERK kinase 1, MEK1, MAP2K1, and PRKMK1.

Rabbit IgG SR: human
Immunogen: synthetic peptide. The epitope recognized by A302-140A maps to a region between residue 343 and 393 of human MAPK/ERK kinase 1 (Dual specificity mitogen-activated protein kinase kinase 1) using the numbering given in entry NP_002746.1 (GeneID 5604).
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A303-610A
IP, IHC Erklärungen der Abkürzungen ansehen.
MEK1 is an activator and kinase for MAP and ERK kinases. It is a serine/threonine kinase essential to the MAP kinase signal transduction pathway which is involved in a multitude of cellular processes such as proliferation, differentiation, gene activation, and development. MEK1 displays 85% identity with MEK2. Although MEK1 and MEK2 have been found to be functionally similar, they may serve non-redundant functions. Both are required for cellular proliferation and may play a role in tumorigenesis. Alternative names for MEK1 include dual specificity mitogen-activated protein kinase kinase 1, MAP kinase kinase 1, MAPKK1, ERK activator kinase 1, MAPK/ERK kinase 1, MEK1, MAP2K1, and PRKMK1.

Rabbit IgG SR: human
Immunogen: Synthetic peptide. The epitope recognized by A303-610A maps to a region of human MAPK/ERK kinase 1 (dual specificity mitogen-activiated protein kinase kinase 1) surrounding threonine 286 using the numbering given in entry NP_002746.1 (Gene ID 5604)
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A303-611A
IP, IHC Erklärungen der Abkürzungen ansehen.
MEK1 is an activator and kinase for MAP and ERK kinases. It is a serine/threonine kinase essential to the MAP kinase signal transduction pathway which is involved in a multitude of cellular processes such as proliferation, differentiation, gene activation, and development. MEK1 displays 85% identity with MEK2. Although MEK1 and MEK2 have been found to be functionally similar, they may serve non-redundant functions. Both are required for cellular proliferation and may play a role in tumorigenesis. Alternative names for MEK1 include dual specificity mitogen-activated protein kinase kinase 1, MAP kinase kinase 1, MAPKK1, ERK activator kinase 1, MAPK/ERK kinase 1, MEK1, MAP2K1, and PRKMK1.

Goat IgG SR: human
Immunogen: Synthetic peptide. The epitope recognized by A303-611A maps to a region of human MAPK/ERK kinase 1 (dual specificity mitogen-activiated protein kinase kinase 1) surrounding threonine 286 using the numbering given in entry NP_002746.1 (Gene ID 5604)
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A310-761A
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1 each of A302-139A and A302-140A

Rabbit IgG SR: human
Immunogen: synthetic peptide
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A311-339A
IP Erklärungen der Abkürzungen ansehen.
1 each of A303-610A and A303-611A

Rabbit IgG SR: human
Immunogen: Synthetic peptide.
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IHC-00619
IHC Erklärungen der Abkürzungen ansehen.
MEK1 is an activator and kinase for MAP and ERK kinases. It is a serine/threonine kinase essential to the MAP kinase signal transduction pathway which is involved in a multitude of cellular processes such as proliferation, differentiation, gene activation, and development. MEK1 displays 85 percent identity with MEK2. Although MEK1 and MEK2 have been found to be functionally similar, they may serve non-redundant functions. Both are required for cellular proliferation and may play a role in tumorigenesis. Alternative names for MEK1 include dual specificity mitogen-activated protein kinase kinase 1, MAP kinase kinase 1, MAPKK1, ERK activator kinase 1, MAPK/ERK kinase 1, MEK1, MAP2K1, and PRKMK1.

Rabbit IgG SR: human
Immunogen: synthetic peptide. The epitope recognized by IHC-00619 maps to a region between residue 343 and 393 of human MAPK/ERK kinase 1 (Dual specificity mitogen-activated protein kinase kinase 1) using the numbering given in entry NP_002746.1 (GeneID 5604).
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A301-544A
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PTPN11/Shp2 is a src-homology 2-containing protein-tyrosine phosphatase (PTP). PTPN11/Shp2 is a non-receptor phosphatase that mediates a variety of cytokine, growth factor, and hormone signals. Signal transduction by PTPN11/Shp2 is achieved via the activation of the Ras/mitogen-activated protein kinase pathway. Heterogenous gain of function mutations in PTPN11/Shp2 are associated with juvenile myelomonocytic leukemia (JMML) and Noonan syndrome, a disorder characterized by short stature, facial dysmorphology, and congenital heart defects. Alternate names for PTPN11/Shp2 include tyrosine-protein phosphatase non-receptor type 11, protein-tyrosine phosphatase 2C, PTP-2C, PTP2C, PTP-1D, CFC, NS1, SH-PTP3 and SH-PTP2.

Rabbit IgG SR: human, mouse
Immunogen: synthetic peptide. The epitope recognized by A301-544A maps to a region between residue 543 and 593 of human tyrosine-protein phosphatase non-receptor type 11 using the numbering given in entry NP_002825.3 (GeneID 5781).
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A300-070A
IP, IHC Erklärungen der Abkürzungen ansehen.
Aurora A is a serine-threonine protein kinase that localizes to centrosomes and spindle poles and is important to spindle assembly and chromosome congression. Substrates of Aurora A kinase activity include BRCA1, CDC25B, and NDEL1. Aurora A has been found to be overexpressed in human cancers. Alternate designations for Aurora A include serine/threonine-protein kinase 6, Aurora kinase A, Aurora A, serine/threonine kinase 15, Aurora/IPL1-related kinase 1, Aurora-related kinase 1, hARK1, breast tumor-amplified kinase, AURKA, AIK, ARK1, AURA, BTAK, STK15, STK6, STK7, AURORA2, and MGC34538.

Rabbit IgG SR: human
Immunogen: synthetic peptide. The epitope recognized by A300-070A maps to a region between residues 50 and 100 of human Aurora A Kinase using the numbering given in entry NP_003591.2 (GeneID 6790).
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A300-071A
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Aurora A is a serine-threonine protein kinase that localizes to centrosomes and spindle poles and is important to spindle assembly and chromosome congression. Substrates of Aurora A kinase activity include BRCA1, CDC25B, and NDEL1. Aurora A has been found to be overexpressed in human cancers. Alternate designations for Aurora A include serine/threonine-protein kinase 6, Aurora kinase A, Aurora A, serine/threonine kinase 15, Aurora/IPL1-related kinase 1, Aurora-related kinase 1, hARK1, breast tumor-amplified kinase, AURKA, AIK, ARK1, AURA, BTAK, STK15, STK6, STK7, AURORA2, and MGC34538.

Rabbit IgG SR: human
Immunogen: synthetic peptide. The epitope recognized by A300-071A maps to a region between residues 75 and 125 of human Aurora A Kinase using the numbering given in entry NP_003591.2 (GeneID 6790).
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A310-018A
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Antibodies were affinity purified using epitopes specific to Aurora A immobilized on solid support.

Rabbit IgG SR: human, mouse, rat
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IHC-00062
ICC Erklärungen der Abkürzungen ansehen.
Aurora A is a serine-threonine protein kinase that localizes to centrosomes and spindle poles and is important to spindle assembly and chromosome congression. Substrates of Aurora A kinase activity include BRCA1, CDC25B, and NDEL1. Aurora A has been found to be overexpressed in human cancers. Alternate designations for Aurora A include serine/threonine-protein kinase 6, Aurora kinase A, Aurora A, serine/threonine kinase 15, Aurora/IPL1-related kinase 1, Aurora-related kinase 1, hARK1, breast tumor-amplified kinase, AURKA, AIK, ARK1, AURA, BTAK, STK15, STK6, STK7, AURORA2, and MGC34538.

Rabbit IgG SR: human
Immunogen: synthetic peptide. The epitope recognized by IHC-00062 maps to a region between residue 75 and 125 of human Aurora A Kinase using the numbering given in entry NP_003591.2 (GeneID 6790).
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IHC-00067
ICC Erklärungen der Abkürzungen ansehen.
Aurora A is a serine-threonine protein kinase that localizes to centrosomes and spindle poles and is important to spindle assembly and chromosome congression. Substrates of Aurora A kinase activity include BRCA1, CDC25B, and NDEL1. Aurora A has been found to be overexpressed in human cancers. Alternate designations for Aurora A include serine/threonine-protein kinase 6, Aurora kinase A, Aurora A, serine/threonine kinase 15, Aurora/IPL1-related kinase 1, Aurora-related kinase 1, hARK1, breast tumor-amplified kinase, AURKA, AIK, ARK1, AURA, BTAK, STK15, STK6, STK7, AURORA2, and MGC34538.

Rabbit IgG SR: human
Immunogen: synthetic peptide. The epitope recognized by IHC-00067 maps to a region surrounding residue 288 when Threonine 288 is phosphorylated of human Aurora A Kinase using the numbering given entry NP_003591.2 (GeneID 6790).
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S300-070
IP Erklärungen der Abkürzungen ansehen.
Rabbit anti-human Aurora A affinity purified Antibodies were coupled to agarose beads using a cyanogen bromide method.

Rabbit IgG SR: human
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S300-071
IP Erklärungen der Abkürzungen ansehen.
Rabbit anti-human Aurora A affinity purified antibodies were coupled to agarose beads using a cyanogen bromide method.

Rabbit IgG SR: human
Immunogen: synthetic peptide
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A300-020A
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MSH2 is an integral component of the DNA mismatch repair (MMR) system that functions to recognize aberrant structures and signals for the repair of single base mismatches or loops in replicated DNA. MSH2 has also been demonstrated to function as an anti-recombinase and may play a role in negatively regulating DNA repair. MSH2 can heterodimerize with MSH3 or MSH6. Mutations in MSH2 are linked to hereditary nonpolyposis colon cancer (HNPCC). Alternate names for MSH2 include DNA mismatch repair protein Msh2, MutS protein homolog 2, MSH2, FCC1, COCA1, HNPCC, and HNPCC1.

Rabbit IgG SR: human
Immunogen: synthetic peptide. The epitope recognized by A300-020A maps to a region between residues 1 and 50 of human mutS homolog 2 using the numbering given in Swiss-Prot entry P43246 (GeneID 4436).
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A300-451A
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MSH2 is an integral component of the DNA mismatch repair (MMR) system that functions to recognize aberrant structures and signals for the repair of single base mismatches or loops in replicated DNA. MSH2 has also been demonstrated to function as an anti-recombinase and may play a role in negatively regulating DNA repair. MSH2 can heterodimerize with MSH3 or MSH6. Mutations in MSH2 are linked to hereditary nonpolyposis colon cancer (HNPCC). Alternate names for MSH2 include DNA mismatch repair protein Msh2, MutS protein homolog 2, MSH2, FCC1, COCA1, HNPCC, and HNPCC1.

Rabbit IgG SR: human
Immunogen: synthetic peptide. The epitope recognized by A300-451A maps to a region between residues 1 and 50 of human mutS homolog 2 using the numbering given in Swiss-Prot entry P43246 (GeneID 4436).
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A300-452A
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WB, IP Erklärungen der Abkürzungen ansehen.
MSH2 is an integral component of the DNA mismatch repair (MMR) system that functions to recognize aberrant structures and signals for the repair of single base mismatches or loops in replicated DNA. MSH2 has also been demonstrated to function as an anti-recombinase and may play a role in negatively regulating DNA repair. MSH2 can heterodimerize with MSH3 or MSH6. Mutations in MSH2 are linked to hereditary nonpolyposis colon cancer (HNPCC). Alternate names for MSH2 include DNA mismatch repair protein Msh2, MutS protein homolog 2, MSH2, FCC1, COCA1, HNPCC, and HNPCC1.

Rabbit IgG SR: human, mouse
Immunogen: synthetic peptide. The epitope recognized by A300-452A maps to a region between residue 875 and the C-terminus (residue 934) of human mutS homolog 2 using the numbering given in Swiss-Prot entry P43246 (GeneID 4436).
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A310-127A
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WB, IP Erklärungen der Abkürzungen ansehen.
Antibodies were affinity purified using epitopes specific to MSH2 immobilized on solid support.

Rabbit IgG SR: human, mouse
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IHC-00082
IHC Erklärungen der Abkürzungen ansehen.
MSH2 is an integral component of the DNA mismatch repair (MMR) system that functions to recognize aberrant structures and signals for the repair of single base mismatches or loops in replicated DNA. MSH2 has also been demonstrated to function as an anti-recombinase and may play a role in negatively regulating DNA repair. MSH2 can heterodimerize with MSH3 or MSH6. Mutations in MSH2 are linked to hereditary nonpolyposis colon cancer (HNPCC). Alternate names for MSH2 include DNA mismatch repair protein Msh2, MutS protein homolog 2, MSH2, FCC1, COCA1, HNPCC, and HNPCC1.

Rabbit IgG SR: human, mouse
Immunogen: synthetic peptide. The epitope recognized by IHC-00082 maps to a region between residue 875 and the C-terminus (residue 934) of human mutS homolog 2 using the numbering given in Swiss-Prot entry P43246 (GeneID 4436).
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S300-020
IP Erklärungen der Abkürzungen ansehen.
Rabbit anti-human MSH2 affinity purified Antibodies were coupled to agarose beads using a cyanogen bromide method.

Rabbit IgG SR: human
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A80-129
IEP, DD Erklärungen der Abkürzungen ansehen.
Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood. Major zinc transporter in plasma, typically binds about 80% of all plasma zinc.

Goat IgG SR: human
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A80-129A
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ELISA, WB, IHC, ICC Erklärungen der Abkürzungen ansehen.
Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood. Major zinc transporter in plasma, typically binds about 80% of all plasma zinc.

Goat IgG SR: human
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A80-129AP
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ELISA, WB, IHC, ICC Erklärungen der Abkürzungen ansehen.
Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood. Major zinc transporter in plasma, typically binds about 80% of all plasma zinc.

Goat IgG SR: human
Bethyl
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A80-129B
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ELISA, WB Erklärungen der Abkürzungen ansehen.
Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood. Major zinc transporter in plasma, typically binds about 80% of all plasma zinc.

Goat IgG SR: human
Immunogen: Human Albumin
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A80-129F
ICC, IHC Erklärungen der Abkürzungen ansehen.
Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood. Major zinc transporter in plasma, typically binds about 80% of all plasma zinc.

Goat IgG SR: human
Bethyl
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A80-129P
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ELISA, WB, IHC, ICC Erklärungen der Abkürzungen ansehen.
Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood. Major zinc transporter in plasma, typically binds about 80% of all plasma zinc.

Goat IgG SR: human
Bethyl
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1 mg

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160 €

A80-229A
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ELISA, WB, IHC, ICC Erklärungen der Abkürzungen ansehen.
Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood. Major zinc transporter in plasma, typically binds about 80% of all plasma zinc.

Goat IgG SR: human
Bethyl
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500 µg

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100 €

A80-229AP
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ELISA, WB, IHC, ICC Erklärungen der Abkürzungen ansehen.
Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood. Major zinc transporter in plasma, typically binds about 80% of all plasma zinc.

Goat IgG SR: human
Bethyl
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500 µg

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174 €

A80-229F
ICC, IHC Erklärungen der Abkürzungen ansehen.
Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood. Major zinc transporter in plasma, typically binds about 80% of all plasma zinc.

Goat IgG SR: human
Bethyl
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500 µg

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127 €

A80-229P
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ELISA, WB, IHC, ICC Erklärungen der Abkürzungen ansehen.
Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood. Major zinc transporter in plasma, typically binds about 80% of all plasma zinc.

Goat IgG SR: human
Bethyl
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E80-129
related products

ELISA Erklärungen der Abkürzungen ansehen.
Antibodies, calibrators and conjugate are packaged to provide a quantitative ELISA kit containing reagents sufficient for 1000 single well assays. Kits do not include plates, buffers or substrate. If needed order ELISA Accessory Kit # E101.
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E88-129
ELISA Erklärungen der Abkürzungen ansehen.
Sandwich ELISA. Complete kit for quantitating human Albumin in in serum, plasma, cerebrospinal fluid, milk, and urine. For up to 40 samples tested in duplicate.
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A300-890A
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Rad9 is a cell-cycle checkpoint protein with 3´-5´ exonuclease activity and is part of the 9-1-1 complex. The 9-1-1 complex, also called the checkpoint clamp, is a trimeric complex that includes Rad9, Hus1, and Rad1. This complex is recruited by the RAD17/RFC clamp loader to DNA lesions where it aids in the activation of Chk2 by ATM and ATRIP and the subsequent triggering of the checkpoint signaling cascade. In addition to its role in sensing DNA damage, Rad9 also functions in the base excision repair process of DNA repair. Alternate designations for Rad9 include cell cycle checkpoint control protein, DNA repair exonuclease rad9 homolog A, and hRAD9.

Rabbit IgG SR: human
Immunogen: synthetic peptide. The epitope recognized by A300-890A maps to a region between residue 350 and the C-terminus (residue 391) of human Rad9 using the numbering given in entry NP_004575.1 (GeneID 5883).
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IHC-00376
IHC, IHC-​IF Erklärungen der Abkürzungen ansehen.
Rad9 is a cell-cycle checkpoint protein with 3´-5´ exonuclease activity and is part of the 9-1-1 complex. The 9-1-1 complex, also called the checkpoint clamp, is a trimeric complex that includes Rad9, Hus1, and Rad1. This complex is recruited by the RAD17/RFC clamp loader to DNA lesions where it aids in the activation of Chk2 by ATM and ATRIP and the subsequent triggering of the checkpoint signaling cascade. In addition to its role in sensing DNA damage, Rad9 also functions in the base excision repair process of DNA repair. Alternate designations for Rad9 include cell cycle checkpoint control protein, DNA repair exonuclease rad9 homolog A, and hRAD9.

Rabbit IgG SR: human
Immunogen: synthetic peptide. The epitope recognized by IHC-00376 maps to a region between residue 350 and the C-terminus (residue 391) of human Rad9 using the numbering given in entry NP_004575.1 (GeneID 5883).
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A301-915A
IP Erklärungen der Abkürzungen ansehen.
TGF-beta activated kinase 1 (TAK1) is involved in the TGF-beta signal transduction pathway. TAK1L is a TAK1-like protein identified in a screen of a fetal brain library. TAK1L mRNA was found to be predominantly expressed in blood leukocytes and ubiquitously in human adult and fetal tissues. TAK1L was also found to be highly expressed in breast, colon, and prostate carcinoma. Alternate names for TAK1L include TAKL, C21orf7, and chromosome 21 open reading frame 7.

Rabbit IgG SR: human
Immunogen: synthetic peptide. The epitope recognized by A301-915A maps to a region between residue 250 and 300 of human transforming growth factor-beta-activated kinase 1 using the numbering given in entry NP_663304.1 (GeneID 6885).
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A301-916A
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TGF-beta activated kinase 1 (TAK1) is involved in the TGF-beta signal transduction pathway. TAK1L is a TAK1-like protein identified in a screen of a fetal brain library. TAK1L mRNA was found to be predominantly expressed in blood leukocytes and ubiquitously in human adult and fetal tissues. TAK1L was also found to be highly expressed in breast, colon, and prostate carcinoma. Alternate names for TAK1L include TAKL, C21orf7, and chromosome 21 open reading frame 7.

Rabbit IgG SR: human
Immunogen: synthetic peptide. The epitope recognized by A301-916A maps to a region between residue 450 and 500 of human transforming growth factor-beta-activated kinase 1 using the numbering given in entry NP_663304.1 (GeneID 6885).
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A310-678A
related products

WB, IP Erklärungen der Abkürzungen ansehen.
1 each of A301-915A and A301-916A

Rabbit IgG SR: human
Immunogen: synthetic peptide
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A300-000A
related products

WB, IP Erklärungen der Abkürzungen ansehen.
BRCA1 was identified as a gene with germline mutations that predisposes women to breast and ovarian cancer. The BRCA1 tumor suppressor is a large protein that has been demonstrated to interact with a multitude of proteins involved in the DNA damage response and cell cycle checkpoints to maintain genomic integrity. BRCA1 functions by regulating the activities of its interacting proteins which mediate processes such as gene transcription, gene repression, protein phosphorylation, and ubiquitination. BRCA1 is also known as breast cancer type 1 susceptibility protein, RING finger protein 53, RNF53, IRIS, PSCP, BRCAI, and BRCC1.

Rabbit IgG SR: human
Immunogen: synthetic peptide. The epitope recognized by A300-000A maps to a region between residue 1800 and the C-terminus (residue 1863) of human Breast Cancer Gene 1 using the numbering given in entry NP_009225.1 (GeneID 672).
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A300-001A
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WB, IP, PLA Erklärungen der Abkürzungen ansehen.
BRCA1 was identified as a gene with germline mutations that predisposes women to breast and ovarian cancer. The BRCA1 tumor suppressor is a large protein that has been demonstrated to interact with a multitude of proteins involved in the DNA damage response and cell cycle checkpoints to maintain genomic integrity. BRCA1 functions by regulating the activities of its interacting proteins which mediate processes such as gene transcription, gene repression, protein phosphorylation, and ubiquitination. BRCA1 is also known as breast cancer type 1 susceptibility protein, RING finger protein 53, RNF53, IRIS, PSCP, BRCAI, and BRCC1.

Rabbit IgG SR: human
Immunogen: synthetic phospho-peptide. Immunogen for A300-001A was a phosphorylated synthetic peptide, which represented a portion of human Breast Cancer Gene 1 (GeneID 672) around serine 1524 according to the numbering given in entry NP_009225.1.
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A300-003A
related products

WB Erklärungen der Abkürzungen ansehen.
BRCA1 was identified as a gene with germline mutations that predisposes women to breast and ovarian cancer. The BRCA1 tumor suppressor is a large protein that has been demonstrated to interact with a multitude of proteins involved in the DNA damage response and cell cycle checkpoints to maintain genomic integrity. BRCA1 functions by regulating the activities of its interacting proteins which mediate processes such as gene transcription, gene repression, protein phosphorylation, and ubiquitination. BRCA1 is also known as breast cancer type 1 susceptibility protein, RING finger protein 53, RNF53, IRIS, PSCP, BRCAI, and BRCC1.

Rabbit IgG SR: human
Immunogen: synthetic phospho-peptide. Immunogen for A300-003A was a phosphorylated synthetic peptide, which represented a portion of human Breast Cancer Gene 1 (GeneID 672) around serine 1189 according to the numbering given in entry NP_009225.1.
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A300-004A
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WB, IP, PLA Erklärungen der Abkürzungen ansehen.
BRCA1 was identified as a gene with germline mutations that predisposes women to breast and ovarian cancer. The BRCA1 tumor suppressor is a large protein that has been demonstrated to interact with a multitude of proteins involved in the DNA damage response and cell cycle checkpoints to maintain genomic integrity. BRCA1 functions by regulating the activities of its interacting proteins which mediate processes such as gene transcription, gene repression, protein phosphorylation, and ubiquitination. BRCA1 is also known as breast cancer type 1 susceptibility protein, RING finger protein 53, RNF53, IRIS, PSCP, BRCAI, and BRCC1.

Rabbit IgG SR: human
Immunogen: synthetic phospho-peptide. Immunogen for A300-004A was a phosphorylated synthetic peptide, which represented a portion of human Breast Cancer Gene 1 (GeneID 672) around serine 1280 according to the numbering given in entry NP_009225.1.
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A300-007A
related products

WB, IP Erklärungen der Abkürzungen ansehen.
BRCA1 was identified as a gene with germline mutations that predisposes women to breast and ovarian cancer. The BRCA1 tumor suppressor is a large protein that has been demonstrated to interact with a multitude of proteins involved in the DNA damage response and cell cycle checkpoints to maintain genomic integrity. BRCA1 functions by regulating the activities of its interacting proteins which mediate processes such as gene transcription, gene repression, protein phosphorylation, and ubiquitination. BRCA1 is also known as breast cancer type 1 susceptibility protein, RING finger protein 53, RNF53, IRIS, PSCP, BRCAI, and BRCC1.

Rabbit IgG SR: human
Immunogen: synthetic phospho-peptide. Immunogen for A300-007A was a phosphorylated synthetic peptide, which represented a portion of human Breast Cancer Gene 1 (GeneID 672) around serine 1387 according to the numbering given in entry NP_009225.1.
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A300-008A
related products

WB Erklärungen der Abkürzungen ansehen.
BRCA1 was identified as a gene with germline mutations that predisposes women to breast and ovarian cancer. The BRCA1 tumor suppressor is a large protein that has been demonstrated to interact with a multitude of proteins involved in the DNA damage response and cell cycle checkpoints to maintain genomic integrity. BRCA1 functions by regulating the activities of its interacting proteins which mediate processes such as gene transcription, gene repression, protein phosphorylation, and ubiquitination. BRCA1 is also known as breast cancer type 1 susceptibility protein, RING finger protein 53, RNF53, IRIS, PSCP, BRCAI, and BRCC1.

Rabbit IgG SR: human
Immunogen: synthetic phospho-peptide. Immunogen for A300-008A was a phosphorylated synthetic peptide, which represented a portion of human Breast Cancer Gene 1 (GeneID 672) around serine 1423 according to the numbering given in entry NP_009225.1.
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A300-009A
related products

WB, IP Erklärungen der Abkürzungen ansehen.
BRCA1 was identified as a gene with germline mutations that predisposes women to breast and ovarian cancer. The BRCA1 tumor suppressor is a large protein that has been demonstrated to interact with a multitude of proteins involved in the DNA damage response and cell cycle checkpoints to maintain genomic integrity. BRCA1 functions by regulating the activities of its interacting proteins which mediate processes such as gene transcription, gene repression, protein phosphorylation, and ubiquitination. BRCA1 is also known as breast cancer type 1 susceptibility protein, RING finger protein 53, RNF53, IRIS, PSCP, BRCAI, and BRCC1.

Rabbit IgG SR: human
Immunogen: synthetic phospho-peptide. Immunogen for A300-009A was a phosphorylated synthetic peptide, which represented a portion of human Breast Cancer Gene 1 (GeneID 672) around serine 1457 according to the numbering given in entry NP_009225.1.
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A300-011A
related products

WB Erklärungen der Abkürzungen ansehen.
BRCA1 was identified as a gene with germline mutations that predisposes women to breast and ovarian cancer. The BRCA1 tumor suppressor is a large protein that has been demonstrated to interact with a multitude of proteins involved in the DNA damage response and cell cycle checkpoints to maintain genomic integrity. BRCA1 functions by regulating the activities of its interacting proteins which mediate processes such as gene transcription, gene repression, protein phosphorylation, and ubiquitination. BRCA1 is also known as breast cancer type 1 susceptibility protein, RING finger protein 53, RNF53, IRIS, PSCP, BRCAI, and BRCC1.

Rabbit IgG SR: human
Immunogen: synthetic phospho-peptide. Immunogen for A300-011A was a phosphorylated synthetic peptide, which represented a portion of human Breast Cancer Gene 1 (GeneID 672) around serine 1466 according to the numbering given in entry NP_009225.1.
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A301-377A
related products

WB, IP, PLA Erklärungen der Abkürzungen ansehen.
BRCA1 was identified as a gene with germline mutations that predisposes women to breast and ovarian cancer. The BRCA1 tumor suppressor is a large protein that has been demonstrated to interact with a multitude of proteins involved in the DNA damage response and cell cycle checkpoints to maintain genomic integrity. BRCA1 functions by regulating the activities of its interacting proteins which mediate processes such as gene transcription, gene repression, protein phosphorylation, and ubiquitination. BRCA1 is also known as breast cancer type 1 susceptibility protein, RING finger protein 53, RNF53, IRIS, PSCP, BRCAI, and BRCC1.

Rabbit IgG SR: human
Immunogen: synthetic peptide. The epitope recognized by A301-377A maps to a region between residue 250 and 300 of human breast cancer 1 using the numbering given in entry NP_009225.1 (GeneID 672).
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A301-378A
related products

WB, IP Erklärungen der Abkürzungen ansehen.
BRCA1 was identified as a gene with germline mutations that predisposes women to breast and ovarian cancer. The BRCA1 tumor suppressor is a large protein that has been demonstrated to interact with a multitude of proteins involved in the DNA damage response and cell cycle checkpoints to maintain genomic integrity. BRCA1 functions by regulating the activities of its interacting proteins which mediate processes such as gene transcription, gene repression, protein phosphorylation, and ubiquitination. BRCA1 is also known as breast cancer type 1 susceptibility protein, RING finger protein 53, RNF53, IRIS, PSCP, BRCAI, and BRCC1.

Rabbit IgG SR: human
Immunogen: synthetic peptide. The epitope recognized by A301-378A maps to a region between residue 700 and 750 of human breast cancer 1 using the numbering given in entry NP_009225.1 (GeneID 672).
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A310-477A
related products

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1 each of A300-000A, A301-377A and A301-378A

Rabbit IgG SR: human
Immunogen: synthetic peptide
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1 pack

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729 €

IHC-00278
IHC Erklärungen der Abkürzungen ansehen.
BRCA1 was identified as a gene with germline mutations that predisposes women to breast and ovarian cancer. The BRCA1 tumor suppressor is a large protein that has been demonstrated to interact with a multitude of proteins involved in the DNA damage response and cell cycle checkpoints to maintain genomic integrity. BRCA1 functions by regulating the activities of its interacting proteins which mediate processes such as gene transcription, gene repression, protein phosphorylation, and ubiquitination. BRCA1 is also known as breast cancer type 1 susceptibility protein, RING finger protein 53, RNF53, IRIS, PSCP, BRCAI, and BRCC1.

Rabbit IgG SR: human
Immunogen: synthetic peptide. The epitope recognized by IHC-00278 maps to a region between residue 700 and 750 of human breast cancer 1 using the numbering given in entry NP_009225.1 (GeneID 672).
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S300-000
IP Erklärungen der Abkürzungen ansehen.
Rabbit anti-human BRCA1 affinity purified Antibodies were coupled to agarose beads using a cyanogen bromide method.

Rabbit IgG SR: human
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A301-985A
related products

WB, IP, PLA Erklärungen der Abkürzungen ansehen.
Bromodomain-containing protein 4 (BRD4) contains 2 bromo-domains. Bromo-domains are found in chromatin-associating proteins and can interact specifically with acetylated lysine. BRD4 is described as a chromatin adaptor and has been shown to bind acetylated chromatin. It was originally identified as MCAP (mitotic chromosome associated protein) due to its association with mitotic chromosomes. BRD4 also associates with several transcription complexes such as the Mediator complexes and P-TEFb complexes and is considered to function as a transcriptional co-factor. Alternate names for BRD4 include MCAP, CAP, Fshrg4, and HUNK1.

Rabbit IgG SR: human
Immunogen: synthetic peptide. The epitope recognized by A301-985A maps to a region between residue 1312 and 1362 of human bromodomain-containing protein 4 using the numbering given in entry NP_490597.1 (GeneID 23476).
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A301-985A100
WB, IP, IHC-​P, IF, PLA Erklärungen der Abkürzungen ansehen.
Bromodomain-containing protein 4 (BRD4) contains 2 bromo-domains. Bromo-domains are found in chromatin-associating proteins and can interact specifically with acetylated lysine. BRD4 is described as a chromatin adaptor and has been shown to bind acetylated chromatin. It was originally identified as MCAP (mitotic chromosome associated protein) due to its association with mitotic chromosomes. BRD4 also associates with several transcription complexes such as the Mediator complexes and P-TEFb complexes and is considered to function as a transcriptional co-factor.

Rabbit IgG SR: human
Immunogen: synthetic peptide. The epitope recognized by A301-985A maps to a region between residue 1312 and 1362 of human bromodomain-containing protein 4 using the numbering given in entry NP_490597.1 (GeneID 23476).
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A301-985A50
WB, IP, IHC-​P, IF, PLA Erklärungen der Abkürzungen ansehen.
Bromodomain-containing protein 4 (BRD4) contains 2 bromo-domains. Bromo-domains are found in chromatin-associating proteins and can interact specifically with acetylated lysine. BRD4 is described as a chromatin adaptor and has been shown to bind acetylated chromatin. It was originally identified as MCAP (mitotic chromosome associated protein) due to its association with mitotic chromosomes. BRD4 also associates with several transcription complexes such as the Mediator complexes and P-TEFb complexes and is considered to function as a transcriptional co-factor.

Rabbit IgG SR: human
Immunogen: synthetic peptide. The epitope recognized by A301-985A maps to a region between residue 1312 and 1362 of human bromodomain-containing protein 4 using the numbering given in entry NP_490597.1 (GeneID 23476).
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IHC-00396
IHC Erklärungen der Abkürzungen ansehen.
Bromodomain-containing protein 4 (BRD4) contains 2 bromo-domains. Bromo-domains are found in chromatin-associating proteins and can interact specifically with acetylated lysine. BRD4 is described as a chromatin adaptor and has been shown to bind acetylated chromatin. It was originally identified as MCAP (mitotic chromosome associated protein) due to its association with mitotic chromosomes. BRD4 also associates with several transcription complexes such as the Mediator complexes and P-TEFb complexes and is considered to function as a transcriptional co-factor. Alternate names for BRD4 include MCAP, CAP, Fshrg4, and HUNK1.

Rabbit IgG SR: human, mouse
Immunogen: synthetic peptide. The epitope recognized by IHC-00396 maps to a region between residue 1312 and 1362 of human bromodomain-containing protein 4 using the numbering given in entry NP_490597.1 (GeneID 23476).
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A301-259A
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PAK1 (p21-activated kinase 1) is part of the family of PAK serine/threonine p21-activating protein kinases involved in cell survival, migration, and invasion. PAK1 mediates signals from extracellular stimuli to the cytoplasm and nucleus via its association with the small GTP-binding proteins, Cdc42 and Rac. GTPase binding to PAK1 activates PAK1 kinase activity and leads to reorganization of the actin cytoskeleton and the phosphorylation of proteins involved in survival, energy metabolism, gene expression, cell motility, cell morphology, and the cell cycle. Alternate names for PAK1 include serine/threonine protein kinase PAK1, PAK-1, p65-PAK, Alpha-PAK, PAKalpha, MGC130000, and MGC130001.

Rabbit IgG SR: human, mouse
Immunogen: synthetic peptide. The epitope recognized by A301-259A maps to a region between residue 1 and 50 of human p21/Cdc42/Rac1-activated kinase 1 using the numbering given in entry NP_002567.3 (GeneID 5058).
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A301-260A
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PAK1 (p21-activated kinase 1) is part of the family of PAK serine/threonine p21-activating protein kinases involved in cell survival, migration, and invasion. PAK1 mediates signals from extracellular stimuli to the cytoplasm and nucleus via its association with the small GTP-binding proteins, Cdc42 and Rac. GTPase binding to PAK1 activates PAK1 kinase activity and leads to reorganization of the actin cytoskeleton and the phosphorylation of proteins involved in survival, energy metabolism, gene expression, cell motility, cell morphology, and the cell cycle. Alternate names for PAK1 include serine/threonine protein kinase PAK1, PAK-1, p65-PAK, Alpha-PAK, PAKalpha, MGC130000, and MGC130001.

Rabbit IgG SR: human
Immunogen: synthetic peptide. The epitope recognized by A301-260A maps to a region between residue 40 and 90 of human p21/Cdc42/Rac1-activated kinase 1 using the numbering given in entry NP_002567.3 (GeneID 5058).
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A310-427A
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Antibodies were affinity purified using epitopes specific to PAK1 immobilized on solid support.

Rabbit IgG SR: human, mouse
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A300-618A
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Chk2 functions as a checkpoint protein kinase in response to DNA damage to maintain genomic stability. The yeast homologs are Rad53 and Cds1. The two major upstream controllers of Chk2 are ATM and ATR which are part of the phosphatidylinositol 3-kinase family. When activated, Chk2 targets p53, BRCA1, Cdc25A and Cdc25C to cause cell cycle arrest. Chk2 is also known as serine/threonine-protein kinase CHK2, CHEK2, CDS1, LFS2, Rad53, HuCds1, and PP1425.

Rabbit IgG SR: human
Immunogen: synthetic peptide. The epitope recognized by A300-618A maps to a region between residues 1 and 50 of human Checkpoint Kinase 2 using the numbering given in entry NP_009125.1 (GeneID 11200).
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A300-619A
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Chk2 functions as a checkpoint protein kinase in response to DNA damage to maintain genomic stability. The yeast homologs are Rad53 and Cds1. The two major upstream controllers of Chk2 are ATM and ATR which are part of the phosphatidylinositol 3-kinase family. When activated, Chk2 targets p53, BRCA1, Cdc25A and Cdc25C to cause cell cycle arrest. Chk2 is also known as serine/threonine-protein kinase CHK2, CHEK2, CDS1, LFS2, Rad53, HuCds1, and PP1425.

Rabbit IgG SR: human
Immunogen: synthetic peptide. The epitope recognized by A300-619A maps to a region between residues 475 and 525 of human Checkpoint Kinase 2 using the numbering given in entry NP_009125.1 (GeneID 11200).
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A300-620A
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Chk2 functions as a checkpoint protein kinase in response to DNA damage to maintain genomic stability. The yeast homologs are Rad53 and Cds1. The two major upstream controllers of Chk2 are ATM and ATR which are part of the phosphatidylinositol 3-kinase family. When activated, Chk2 targets p53, BRCA1, Cdc25A and Cdc25C to cause cell cycle arrest. Chk2 is also known as serine/threonine-protein kinase CHK2, CHEK2, CDS1, LFS2, Rad53, HuCds1, and PP1425.

Rabbit IgG SR: human
Immunogen: synthetic peptide. The epitope recognized by A300-619A maps to a region between residue 500 and the C-terminus (residue 543) of human Checkpoint Kinase 2 using the numbering given in entry NP_009125.1 (GeneID 11200).
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A310-182A
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Antibody was affinity purified using an epitope specific to Chk2 immobilized on solid support.

Rabbit IgG SR: human
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IHC-00043
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Chk2 functions as a checkpoint protein kinase in response to DNA damage to maintain genomic stability. The yeast homologs are Rad53 and Cds1. The two major upstream controllers of Chk2 are ATM and ATR which are part of the phosphatidylinositol 3-kinase family. When activated, Chk2 targets p53, BRCA1, Cdc25A and Cdc25C to cause cell cycle arrest. Chk2 is also known as serine/threonine-protein kinase CHK2, CHEK2, CDS1, LFS2, Rad53, HuCds1, and PP1425.

Rabbit IgG SR: human
Immunogen: synthetic peptide. The epitope recognized by IHC-00043 maps to a region between residue 475 and 525 of human Checkpoint Kinase 2 using the numbering given in entry NP_009125.1 (GeneID 11200).
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A300-448A
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MnSOD (manganese superoxide dismutase) is a mitochondrial dismutase that catalyzes the conversion of superoxide byproducts of oxidative phosphorylation to hydrogen peroxide and diatomic oxygen. Alternate names for MnSOD include indophenoloxidase B, mitochondrial superoxide dismutase 2, IPO-B, Mn-SOD, and MNSOD.

Goat IgG SR: rat
Immunogen: synthetic peptide. The epitope recognized by A300-448A maps to a region between residue 75 and 125 of human Manganese Superoxide Dismutase using the numbering given in entry NP_000627.2 (GeneID 6648).
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A300-449A
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MnSOD (manganese superoxide dismutase) is a mitochondrial dismutase that catalyzes the conversion of superoxide byproducts of oxidative phosphorylation to hydrogen peroxide and diatomic oxygen. Alternate names for MnSOD include indophenoloxidase B, mitochondrial superoxide dismutase 2, IPO-B, Mn-SOD, and MNSOD.

Goat IgG SR: rat
Immunogen: synthetic peptide. The epitope recognized by A300-449A maps to a region between residue 175 and the C-terminus (residue 222) of human Manganese Superoxide Dismutase using the numbering given in entry NP_000627.2 (GeneID 6648).
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A310-113A
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Antibodies were affinity purified using epitopes specific to MnSOD immobilized on solid support.

Goat IgG SR: rat
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A302-844A
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Heat shock protein 60 (HSP60) is a member of the chaperonin family. HSP60 is a mitochondrial protein that may function as a signaling molecule in the innate immune system. It is essential for the folding and assembly of newly imported proteins in the mitochondria. Alternative names for HSP60 include 60kDa heat shock protein mitochondrial, HSP-60, Hsp60, 60 kDa chaperonin, Chaperonin 60, CPN60, mitochondrial matrix protein P1, P60 lymphocyte protein, HuCHA60, and HSPD1. [taken from NCBI Entrez Gene (GeneID: 3329)]

Rabbit IgG SR: human, mouse
Immunogen: synthetic peptide. The epitope recognized by A302-844A maps to a region between residue 50 and 100 of human Heat Shock Protein 60 using the numbering given in entry NP_002147.2 (GeneID 3329).
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A302-845A
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Heat shock protein 60 (HSP60) is a member of the chaperonin family. HSP60 is a mitochondrial protein that may function as a signaling molecule in the innate immune system. It is essential for the folding and assembly of newly imported proteins in the mitochondria. Alternative names for HSP60 include 60kDa heat shock protein mitochondrial, HSP-60, Hsp60, 60 kDa chaperonin, Chaperonin 60, CPN60, mitochondrial matrix protein P1, P60 lymphocyte protein, HuCHA60, and HSPD1. [taken from NCBI Entrez Gene (GeneID: 3329)]

Rabbit IgG SR: human, mouse
Immunogen: synthetic peptide. The epitope recognized by A302-845A maps to a region between residue 250 and 300 of human Heat Shock Protein 60 using the numbering given in entry NP_002147.2 (GeneID 3329).
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A302-846A
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Heat shock protein 60 (HSP60) is a member of the chaperonin family. HSP60 is a mitochondrial protein that may function as a signaling molecule in the innate immune system. It is essential for the folding and assembly of newly imported proteins in the mitochondria. Alternative names for HSP60 include 60kDa heat shock protein mitochondrial, HSP-60, Hsp60, 60 kDa chaperonin, Chaperonin 60, CPN60, mitochondrial matrix protein P1, P60 lymphocyte protein, HuCHA60, and HSPD1. [taken from NCBI Entrez Gene (GeneID: 3329)]

Rabbit IgG SR: human
Immunogen: synthetic peptide. The epitope recognized by A302-846A maps to a region between residue 300 and 350 of human Heat Shock Protein 60 using the numbering given in entry NP_002147.2 (GeneID 3329).
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A311-049A
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1 each of A302-844A, A302-845A and A302-846A

Rabbit IgG SR: human, mouse
Immunogen: synthetic peptide
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A302-019A
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Shc1 (src-homology domain protein C1) was originally identified as an SH2 containing proto-oncogene involved in growth factor signaling. Shc1 is functions as a signaling adapter that couples activated growth factor receptors to signaling pathways. Shc1 is also known as Shc, and ShcA.

Rabbit IgG SR: human
Immunogen: synthetic peptide. The epitope recognized by A302-019A maps to a region between residue 300 and 350 of human SHC (Src homology 2 domain containing) transforming protein 1 using the numbering given in entry NP_892113.4 (GeneID 6464).
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A302-020A
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Shc1 (src-homology domain protein C1) was originally identified as an SH2 containing proto-oncogene involved in growth factor signaling. Shc1 is functions as a signaling adapter that couples activated growth factor receptors to signaling pathways. Shc1 is also known as Shc, and ShcA.

Rabbit IgG SR: human
Immunogen: synthetic peptide. The epitope recognized by A302-020A maps to a region between residue 359 and 409 of human SHC (Src homology 2 domain containing) transforming protein 1 using the numbering given in entry NP_892113.4 (GeneID 6464).
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A310-712A
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1 each of A302-019A and A302-020A

Rabbit IgG SR: human
Immunogen: synthetic peptide
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IHC-00587
IHC Erklärungen der Abkürzungen ansehen.
Shc1 (src-homology domain protein C1) was originally identified as an SH2 containing proto-oncogene involved in growth factor signaling. Shc1 is functions as a signaling adapter that couples activated growth factor receptors to signaling pathways. Shc1 is also known as Shc, and ShcA.

Rabbit IgG SR: human
Immunogen: synthetic peptide. The epitope recognized by IHC-00587 maps to a region between residue 359 and 409 of human SHC (Src homology 2 domain containing) transforming protein 1 using the numbering given in entry NP_892113.4 (GeneID 6464).
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A303-490A
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The glucocorticoid receptor (GR) functions as both a transcription factor that binds to glucocorticoid response elements in the promoters of glucocorticoid responsive genes to activate their transcription, and as a regulator of other transcription factors. This receptor is typically found in the cytoplasm, but upon ligand binding, is transported into the nucleus. It is involved in inflammatory responses, cellular proliferation, and differentiation in target tissues. Alternative names for the Glucocorticoid receptor include GR, GRL, NR3C1, and nuclear receptor subfamily 3 group C, member 1. [taken from NCBI Entrez Gene (Gene ID: 2908)]

Rabbit IgG SR: human
Immunogen: synthetic peptide. The epitope recognized by A303-490A maps to a region between residue 1 and 50 of human Glucocorticoid Receptor using the numbering given in entry NP_000167.1 (GeneID 2908).
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A303-491A
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The glucocorticoid receptor (GR) functions as both a transcription factor that binds to glucocorticoid response elements in the promoters of glucocorticoid responsive genes to activate their transcription, and as a regulator of other transcription factors. This receptor is typically found in the cytoplasm, but upon ligand binding, is transported into the nucleus. It is involved in inflammatory responses, cellular proliferation, and differentiation in target tissues. Alternative names for the Glucocorticoid receptor include GR, GRL, NR3C1, and nuclear receptor subfamily 3 group C, member 1. [taken from NCBI Entrez Gene (Gene ID: 2908)]

Rabbit IgG SR: human
Immunogen: synthetic peptide. The epitope recognized by A303-491A maps to a region between residue 150 and 200 of human Glucocorticoid Receptor using the numbering given in entry NP_000167.1 (GeneID 2908).
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A311-288A
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1 each of A303-490A and A303-491A

Rabbit SR: human
Immunogen: synthetic peptide
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A301-200A
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The epitope recognized by A301-200A maps to a region between residue 350 and 400 of human progesterone receptor using the numbering given in entry NP_000917.3 (GeneID 5241).

Rabbit IgG SR: human
Immunogen: synthetic peptide. The epitope recognized by A301-200A maps to a region between residue 350 and 400 of human progesterone receptor using the numbering given in entry NP_000917.3 (GeneID 5241).
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A301-258A
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Integrin-linked kinase (ILK) is a serine/threonine kinase associated with the cytoplasmic domain of beta integrins and mediates integrin signaling from the extracellular matrix to the intracellular actin cytoskeleton. PKB/Akt and GSK-3beta are targets of ILK involved in integrin-mediated cell proliferation and cell survival. ILK has been shown to interact with Paxillin, PINCH-1, PINCH-2, and parvin to influence actin dynamics. Alternate names for ILK include ILK-1, ILK-2, p59ILK, P59, and DKFZp686F1765.

Rabbit IgG SR: human, mouse
Immunogen: synthetic peptide. The epitope recognized by A301-258A maps to a region between residue 402 and 451 of human integrin-linked kinase using the numbering given in entry NP_004508.1 (GeneID 3611).
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IHC-00361
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Integrin-linked kinase (ILK) is a serine/threonine kinase associated with the cytoplasmic domain of beta integrins and mediates integrin signaling from the extracellular matrix to the intracellular actin cytoskeleton. PKB/Akt and GSK-3beta are targets of ILK involved in integrin-mediated cell proliferation and cell survival. ILK has been shown to interact with Paxillin, PINCH-1, PINCH-2, and parvin to influence actin dynamics. Alternate names for ILK include ILK-1, ILK-2, p59ILK, P59, and DKFZp686F1765.

Rabbit IgG SR: human
Immunogen: synthetic peptide. The epitope recognized by IHC-00261 maps to a region between residue 402 and 451 of human integrin-linked kinase using the numbering given in entry NP_004508.1 (GeneID 3611).
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A302-855A
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Rabbit IgG SR: human, mouse
Immunogen: Synthetic peptide. The epitope recognized by A302-855A maps to a region between residue 325 and 375 of human Sequestosome-1 using the numbering given in entry NP_003891.1 (GeneID 8878).
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A302-856A
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Rabbit IgG SR: human
Immunogen: Synthetic peptide. The epitope recognized by A302-856A maps to a region between residue 375 and 425 of human Sequestosome-1 using the numbering given in entry NP_003891.1 (GeneID 8878).
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A302-857A
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Rabbit IgG SR: human, mouse
Immunogen: Synthetic peptide. The epitope recognized by A302-857A maps to a region between residue 425 and 440 of human Sequestosome-1 using the numbering given in entry NP_003891.1 (GeneID 8878).
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A311-053A
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Rabbit IgG SR: human, mouse
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A300-250A
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Polo-like kinase 1 (PLK1) activity is central to the progression through mitosis. PLK1 plays an essential role in spindle formation and chromosome segregation. Recent studies suggest that PLK1 is specifically involved in anaphase spindle elongation, Rho localization to the contractile ring and cytokinesis. Alternate names for PLK1 include PLK-1, polo-like kinase 1, STPK13, and serine-threonine kinase 13.

Rabbit IgG SR: human
Immunogen: synthetic peptide. The epitopes recognized by A300-250A maps to a region between residues 1 and 50 of human Polo-like kinase 1 using the numbering given in SwissProt entry P53350 (GeneID 5347).
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A300-251A
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Polo-like kinase 1 (PLK1) activity is central to the progression through mitosis. PLK1 plays an essential role in spindle formation and chromosome segregation. Recent studies suggest that PLK1 is specifically involved in anaphase spindle elongation, Rho localization to the contractile ring and cytokinesis. Alternate names for PLK1 include PLK-1, polo-like kinase 1, STPK13, and serine-threonine kinase 13.

Rabbit IgG SR: human
Immunogen: synthetic peptide. The epitopes recognized by A300-251A maps to a region between residues 325 and 375 of human Polo-like kinase using the numbering given in SwissProt entry P53350 (GeneID 5347).
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A300-252A
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Polo-like kinase 1 (PLK1) activity is central to the progression through mitosis. PLK1 plays an essential role in spindle formation and chromosome segregation. Recent studies suggest that PLK1 is specifically involved in anaphase spindle elongation, Rho localization to the contractile ring and cytokinesis. Alternate names for PLK1 include PLK-1, polo-like kinase 1, STPK13, and serine-threonine kinase 13.

Rabbit IgG SR: human
Immunogen: synthetic peptide. The epitopes recognized by A300-252A maps to a region between residue 550 and the C-terminus (residue 603) of human Polo-like kinase using the numbering given in SwissProt entry P53350 (GeneID 5347).
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A310-069A
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Antibodies were affinity purified using epitopes specific to PLK1 immobilized on solid support.

Rabbit IgG SR: human
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IHC-00071
ICC Erklärungen der Abkürzungen ansehen.
Polo-like kinase 1 (PLK1) activity is central to the progression through mitosis. PLK1 plays an essential role in spindle formation and chromosome segregation. Recent studies suggest that PLK1 is specifically involved in anaphase spindle elongation, Rho localization to the contractile ring and cytokinesis. Alternate names for PLK1 include PLK-1, polo-like kinase 1, STPK13, and serine-threonine kinase 13.

Rabbit IgG SR: human
Immunogen: synthetic peptide. The epitopes recognized by IHC-00071 maps to a region between residues 325 and 375 of human Polo-like kinase using the numbering given in SwissProt entry P53350 (GeneID 5347).
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E88-122
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1 x 96 well kit. This ELISA is for the detection of human alpha-1 Antitrypsin. It contains sufficient components to quantitate human alpha-1 Antitrypsin in up to 40 samples, tested in duplicate.
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A301-649A
IP Erklärungen der Abkürzungen ansehen.
Activating transcription factor 2 (ATF2) is a leucine-zipper transcription factor that binds to the cAMP-responsive element (CRE). ATF2 is involved in regulating the expression of a variety of proteins that are important to oncogenesis. It is a substrate of the JNK/p38 and ATM/ATR protein kinases which regulate its transactivating activity in response to environmental signals. Alternate names for ATF2 include cAMP response element-binding protein CRE-BP1, HB16, CREB2, and CREBP1.

Rabbit IgG SR: human
Immunogen: synthetic peptide. The epitope recognized by A301-649A maps to a region between residue 250 and 300 of human activating transcription factor 2 using the numbering given in entry AAY17203.1 (GeneID 1386).
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A301-650A
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Activating transcription factor 2 (ATF2) is a leucine-zipper transcription factor that binds to the cAMP-responsive element (CRE). ATF2 is involved in regulating the expression of a variety of proteins that are important to oncogenesis. It is a substrate of the JNK/p38 and ATM/ATR protein kinases which regulate its transactivating activity in response to environmental signals. Alternate names for ATF2 include cAMP response element-binding protein CRE-BP1, HB16, CREB2, and CREBP1.

Rabbit IgG SR: human
Immunogen: synthetic peptide. The epitope recognized by A301-650A maps to a region between residue 437 and 487 of human activating transcription factor 2 using the numbering given in entry AAY17203.1 (GeneID 1386).
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A310-587A
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1 each of A301-649A and A301-650A

Rabbit IgG
Immunogen: synthetic peptide
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IHC-00055
IHC Erklärungen der Abkürzungen ansehen.
CD31 is also known as PECAM1 (platelet/endothelial cell adhesion molecule).  CD31 is a cell adhesion molecule expressed mainly in platelets, endothelial cells, and a subset of leukocytes. CD31 localizes to cell-cell junctions and functions as a signaling molecule involved in a variety of vascular-related processes such as angiogenesis, platelet function, and inflammation. Alternate names for CD31 include endocam, GPIIA, CD31 antigen, and PECAM-1.

Rabbit IgG SR: human
Immunogen: synthetic peptide. The epitope recognized by IHC-00050 maps to a region between residue 700 and the C-terminus (residue 738) of human CD31 using the numbering given in entry NP_000433.2 (GeneID 5175).
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A303-430A
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Lamins are components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane, which is thought to provide a framework for the nuclear envelope and may also interact with chromatin. Lamin A and C are present in equal amounts in the lamina of mammals. Lamin A/C plays an important role in nuclear assembly, chromatin organization, nuclear membrane and telomere dynamics. Alternative names for Lamin A/C include 70 kDa lamin, renal carcinoma antigen NY-REN-32, prelamin-A/C, LMNA, LMN1. [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/ P02545].

Rabbit IgG SR: human
Immunogen: synthetic peptide. The epitope recognized by A303-430A maps to a region between residue 1 and 50 of human Lamin A/Lamin C using the numbering given in entry NP_733821.1 (GeneID 4000).
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A303-431A
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Lamins are components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane, which is thought to provide a framework for the nuclear envelope and may also interact with chromatin. Lamin A and C are present in equal amounts in the lamina of mammals. Lamin A/C plays an important role in nuclear assembly, chromatin organization, nuclear membrane and telomere dynamics. Alternative names for Lamin A/C include 70 kDa lamin, renal carcinoma antigen NY-REN-32, prelamin-A/C, LMNA, LMN1. [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/ P02545].

Rabbit IgG SR: human, mouse
Immunogen: synthetic peptide. The epitope recognized by A303-431A maps to a region between residue 150 and 200 of human Lamin A/Lamin C using the numbering given in entry NP_733821.1 (GeneID 4000).
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A303-432A
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Lamins are components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane, which is thought to provide a framework for the nuclear envelope and may also interact with chromatin. Lamin A and C are present in equal amounts in the lamina of mammals. Lamin A/C plays an important role in nuclear assembly, chromatin organization, nuclear membrane and telomere dynamics. Alternative names for Lamin A/C include 70 kDa lamin, renal carcinoma antigen NY-REN-32, prelamin-A/C, LMNA, LMN1. [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/ P02545].

Rabbit IgG SR: human
Immunogen: synthetic peptide. The epitope recognized by A303-432A maps to a region between residue 400 and 450 of human Lamin A using the numbering given in entry NP_733821.1 (GeneID 4000).
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A303-433A
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Lamins are components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane, which is thought to provide a framework for the nuclear envelope and may also interact with chromatin. Lamin A and C are present in equal amounts in the lamina of mammals. Lamin A/C plays an important role in nuclear assembly, chromatin organization, nuclear membrane and telomere dynamics. Alternative names for Lamin A/C include 70 kDa lamin, renal carcinoma antigen NY-REN-32, prelamin-A/C, LMNA, LMN1. [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/ P02545].

Rabbit IgG SR: human, mouse
Immunogen: synthetic peptide. The epitope recognized by A303-433A maps to a region between residue 550 and 600 of human Lamin A using the numbering given in entry NP_733821.1 (GeneID 4000).
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A311-266A
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1 each of A303-430A, A303-431A, A303-432A and A303-433A

Rabbit IgG SR: human, mouse
Immunogen: synthetic peptide
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A300-286A
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Hypoxia-inducible factor-1 (HIF1) is a basic helix-loop-helix (bHLH)-PER-ARNT-sim (PAS) transcription factor that plays a role in the cellular response to hypoxia. HIF1 is a heterodimer of an HIF1-alpha and HIF1-beta subunit. During normoxia, HIF-1alpha is regulated by ubiquitination and interaction with the von-Hippel-Lindau tumor suppressor protein (pVHL). Alternate names for HIF1-alpha include HIF-1 alpha, ARNT-interacting protein, member of PAS protein 1, basic-helix-loop-helix-PAS protein MOP1, HIF1A, MOP1, and PASD8.

Rabbit IgG SR: human, mouse
Immunogen: synthetic peptide. The epitope recognized by A300-286A maps to a region between residues 775 and the C-terminus (residue 826) of human hypoxia-inducible factor 1, alpha subunit using the numbering given in Swiss-Prot entry Q16665 (GeneID 3091).
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A303-907A
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Hypoxia-inducible factor-1 (HIF1) is a basic helix-loop-helix (bHLH)-PER-ARNT-sim (PAS) transcription factor that plays a role in the cellular response to hypoxia. HIF1 is a heterodimer of an HIF1-alpha and HIF1-beta subunit. During normoxia, HIF-1alpha is regulated by ubiquitination and interaction with the von-Hippel-Lindau tumor suppressor protein (pVHL).

Goat IgG SR: human
Immunogen: Synthetic peptide. The epitope recognized by A303-907A maps to a region between residue 776 and 826 of human Hypoxia-Inducible Factor 1, Alpha Subunit using the numbering given in entry NP_001521.1 (GeneID 3091).
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IHC-00460
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Hypoxia-inducible factor-1 (HIF1) is a basic helix-loop-helix (bHLH)-PER-ARNT-sim (PAS) transcription factor that plays a role in the cellular response to hypoxia. HIF1 is a heterodimer of an HIF1-alpha and HIF1-beta subunit. During normoxia, HIF-1alpha is regulated by ubiquitination and interaction with the von-Hippel-Lindau tumor suppressor protein (pVHL). Alternate names for HIF1-alpha include HIF-1 alpha, ARNT-interacting protein, member of PAS protein 1, basic-helix-loop-helix-PAS protein MOP1, HIF1A, MOP1, and PASD8.

Rabbit IgG SR: human, mouse
Immunogen: synthetic peptide. The epitope recognized by IHC-00460 maps to a region between residues 775 and the C-terminus (residue 826) of human hypoxia-inducible factor 1, alpha subunit using the numbering given in Swiss-Prot entry Q16665 (GeneID 3091).
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A302-458A
IP Erklärungen der Abkürzungen ansehen.
Ribosomal protein S6 kinase alpha-1 (RSK1) is a member of the RSK (ribosomal S6 kinase) family of serine/threonine kinases. RSK1 kinase contains 2 non-identical kinase catalytic domains and phosphorylates various substrates, including members of the mitogen-activated kinase (MAPK) signaling pathway. The activity of this protein has been implicated in controlling cell growth and differentiation. Alternative names for RSK1 include 90kDa ribosomal protein S6 kinase 1, p90-RSK1, pp90RSK1, p90S6K, ribosomal S6 kinase 1, RSK-1, MAP kinase-activated protein kinase 1a, MAPKAPK1A, and RPS6KA1.

Rabbit IgG SR: human
Immunogen: synthetic peptide. The epitope recognized by A302-458A maps to a region between residue 375 and 425 of human 90 kDa ribosomal protein S6 kinase 1 using the numbering given in entry NP_002944.2 (GeneID 6195).
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A302-459A
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Ribosomal protein S6 kinase alpha-1 (RSK1) is a member of the RSK (ribosomal S6 kinase) family of serine/threonine kinases. RSK1 kinase contains 2 non-identical kinase catalytic domains and phosphorylates various substrates, including members of the mitogen-activated kinase (MAPK) signaling pathway. The activity of this protein has been implicated in controlling cell growth and differentiation. Alternative names for RSK1 include 90kDa ribosomal protein S6 kinase 1, p90-RSK1, pp90RSK1, p90S6K, ribosomal S6 kinase 1, RSK-1, MAP kinase-activated protein kinase 1a, MAPKAPK1A, and RPS6KA1.

Rabbit IgG SR: human
Immunogen: synthetic peptide. The epitope recognized by A302-459A maps to a region between residue 675 and 725 of human 90 kDa ribosomal protein S6 kinase 1 using the numbering given in entry NP_002944.2 (GeneID 6195).
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A310-892A
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1 each of A302-458A and A302-459A

Rabbit IgG SR: human
Immunogen: synthetic peptide
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IHC-00682
IHC, IHC-​IF Erklärungen der Abkürzungen ansehen.
Ribosomal protein S6 kinase alpha-1 (RSK1) is a member of the RSK (ribosomal S6 kinase) family of serine/threonine kinases. RSK1 kinase contains 2 non-identical kinase catalytic domains and phosphorylates various substrates, including members of the mitogen-activated kinase (MAPK) signaling pathway. The activity of this protein has been implicated in controlling cell growth and differentiation. Alternative names for RSK1 include 90kDa ribosomal protein S6 kinase 1, p90-RSK1, pp90RSK1, p90S6K, ribosomal S6 kinase 1, RSK-1, MAP kinase-activated protein kinase 1a, MAPKAPK1A, and RPS6KA1. [taken from NCBI Entrez Gene (GeneID: 6195)]

Rabbit IgG
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A304-460A
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neu

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PPAR-gamma is a nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. PPAR-gamma is a key regulator of adipocyte differentiation and glucose homeostasis and acts as a critical regulator of gut homeostasis by suppressing NF-kappa-B-mediated proinflammatory responses [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/P37231].

Rabbit IgG SR: human, mouse
Immunogen: synthetic peptide. The epitope recognized by A304-460A maps to a region between residue 50 to 100 of human Peroxisome Proliferator-Activated Receptor Gamma using the numbering given in entry NP_056953.2 (GeneID 5468).
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A304-461A
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PPAR-gamma is a nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. PPAR-gamma is a key regulator of adipocyte differentiation and glucose homeostasis and acts as a critical regulator of gut homeostasis by suppressing NF-kappa-B-mediated proinflammatory responses [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/P37231].

Rabbit IgG SR: human, mouse
Immunogen: synthetic peptide. The epitope recognized by A304-461A maps to a region between residue 100 to 150 of human Peroxisome Proliferator-Activated Receptor Gamma using the numbering given in entry NP_056953.2 (GeneID 5468).
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A311-580A
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neu

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1 each of A304-460A and A304-461A

Rabbit IgG SR: human, mouse
Immunogen: synthetic peptide. Antibodies were affinity purified using epitopes specific to PPAR-gamma immobilized on solid support.
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A303-504A
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Transcription initiation factor TFIID subunit 1 (TAF1) is the largest component and core scaffold of the TFIID basal transcription factor complex. TAF1 contains novel N- and C-terminal Ser/Thr kinase domains which can autophosphorylate or transphosphorylate other transcription factors. TAF1 phosphorylates TP53 on 'Thr-55' which leads to MDM2-mediated degradation of TP53. It also phosphorylates GTF2A1 and GTF2F1 on Ser residues. TAF1 possesses DNA-binding activity and is essential for progression of the G1 phase of the cell cycle. Alternative names for TAF1 include cell cycle gene 1 protein, TBP-associated factor 250 kDa, p250, TAF(II)250, TAFII-250, TAFII250, BA2R, CCG1, CCGS, TAF2A. [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/P21675]

Rabbit IgG SR: human
Immunogen: synthetic peptide. The epitope recognized by A303-504A maps to a region between residue 1750 and 1800 of human Transcription Initiation Factor TFIID Subunit 1 using the numbering given in entry NP_620278.1 (GeneID 6872).
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A311-292A
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1 each of A303-504A and A303-505A

Rabbit SR: human
Immunogen: synthetic peptide
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A300-086A
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MLL1 (mixed lineage leukemia 1) has been found to participate in a multitude of chromosomal translocations that are associated with a variety of hematologic malignancies. MLL1 functions as a transcriptional regulator and plays and important role in HOX gene expression during embryonic development. Alternate names for MLL1 include zinc-finger protein HRX, ALL-1, trithorax-like protein, MLL, ALL1, HRX, HTRX1, THRX, TRX1, CXXC7, MLL1A, FLJ11783, and MLL/GAS7.

Rabbit IgG SR: human, mouse
Immunogen: synthetic peptide. The epitope recognized by A300-086A maps to a region between residues 720 and 780 of human myeloid/lymphoid or mixed-lineage leukemia 1 using the number given in Swiss-Prot entry Q03164 (GeneID 4297).
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A300-087A
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MLL1 (mixed lineage leukemia 1) has been found to participate in a multitude of chromosomal translocations that are associated with a variety of hematologic malignancies. MLL1 functions as a transcriptional regulator and plays and important role in HOX gene expression during embryonic development. Alternate names for MLL1 include zinc-finger protein HRX, ALL-1, trithorax-like protein, MLL, ALL1, HRX, HTRX1, THRX, TRX1, CXXC7, MLL1A, FLJ11783, and MLL/GAS7.

Rabbit IgG SR: human, mouse
Immunogen: synthetic peptide. The epitope recognized by A300-087A maps to a region between residues 1320 and 1380 of human myeloid/lymphoid or mixed-lineage leukemia 1 using the number given in Swiss-Prot entry Q03164 (GeneID 4297).
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A300-374A
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MLL1 (mixed lineage leukemia 1) has been found to participate in a multitude of chromosomal translocations that are associated with a variety of hematologic malignancies. MLL1 functions as a transcriptional regulator and plays and important role in HOX gene expression during embryonic development. Alternate names for MLL1 include zinc-finger protein HRX, ALL-1, trithorax-like protein, MLL, ALL1, HRX, HTRX1, THRX, TRX1, CXXC7, MLL1A, FLJ11783, and MLL/GAS7.

Rabbit IgG SR: human
Immunogen: synthetic peptide. The epitope recognized by A300-374A maps to a region between residues 2725 and 2775 of human myeloid/lymphoid or mixed-lineage leukemia 1 using the number given in Swiss-Prot entry Q03164 (GeneID 4297).
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A300-375A
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WB Erklärungen der Abkürzungen ansehen.
MLL1 (mixed lineage leukemia 1) has been found to participate in a multitude of chromosomal translocations that are associated with a variety of hematologic malignancies. MLL1 functions as a transcriptional regulator and plays and important role in HOX gene expression during embryonic development. Alternate names for MLL1 include zinc-finger protein HRX, ALL-1, trithorax-like protein, MLL, ALL1, HRX, HTRX1, THRX, TRX1, CXXC7, MLL1A, FLJ11783, and MLL/GAS7.

Rabbit IgG SR: human
Immunogen: synthetic peptide. The epitope recognized by A300-375A maps to a region between residue 3900 and the C-terminus (residue 3969) of human myeloid/lymphoid or mixed-lineage leukemia 1 using the number given in Swiss-Prot entry Q03164 (GeneID 4297).
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A310-023A
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Antibodies were affinity purified using epitopes specific to MLL1 immobilized on solid support.

Rabbit IgG SR: human, mouse
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A301-167A
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PML is a member of RBCC/TRIM family of proteins that possess a RING finger domain, B-box, and coiled-coil domain. PML is a multifunctional protein involved in activities such as tumor growth suppression, hematopoietic differentiation, gene transcription, apoptotic induction, and viral immunity. PML is often involved in chromosomal translocations with the retinoic acid receptor alpha gene. PML-retinoic acid receptor translocations are associated with acute promyelocytic leukemia. Alternate names for PML include probable transcription factor PML, tripartite motif-containing protein 19, RING finger protein 71, MYL, RNF71, TRIM19, and PP8675.

Rabbit IgG SR: human
Immunogen: synthetic peptide. The epitope recognized by A301-167A maps to a region between residue 375 and 425 of promyelocytic leukemia using the numbering given in entry NP_150241.2 (GeneID 5371).
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A301-168A
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PML is a member of RBCC/TRIM family of proteins that possess a RING finger domain, B-box, and coiled-coil domain. PML is a multifunctional protein involved in activities such as tumor growth suppression, hematopoietic differentiation, gene transcription, apoptotic induction, and viral immunity. PML is often involved in chromosomal translocations with the retinoic acid receptor alpha gene. PML-retinoic acid receptor translocations are associated with acute promyelocytic leukemia. Alternate names for PML include probable transcription factor PML, tripartite motif-containing protein 19, RING finger protein 71, MYL, RNF71, TRIM19, and PP8675.

Rabbit IgG SR: human
Immunogen: synthetic peptide. The epitope recognized by A301-168A maps to a region between residue 575 and 625 of promyelocytic leukemia using the numbering given in entry NP_150241.2 (GeneID 5371).
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A310-390A
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1 each of A301-167A and A301-168A

Rabbit IgG SR: human
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IHC-00241
IHC Erklärungen der Abkürzungen ansehen.
PML is a member of RBCC/TRIM family of proteins that possess a RING finger domain, B-box, and coiled-coil domain. PML is a multifunctional protein involved in activities such as tumor growth suppression, hematopoietic differentiation, gene transcription, apoptotic induction, and viral immunity. PML is often involved in chromosomal translocations with the retinoic acid receptor alpha gene. PML-retinoic acid receptor translocations are associated with acute promyelocytic leukemia. Alternate names for PML include probable transcription factor PML, tripartite motif-containing protein 19, RING finger protein 71, MYL, RNF71, TRIM19, and PP8675.

Rabbit IgG SR: human
Immunogen: synthetic peptide. The epitope recognized by IHC-00241 maps to a region between residue 375 and 425 of promyelocytic leukemia using the numbering given in entry NP_150241.2 (GeneID 5371).
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A300-744A
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DJ-1 appears to have a function in many biological processes. DJ-1 was first reported as an oncogene and then identified as a gene linked to Parkinson disease, a common neurodegenerative order. DJ-1 has also been observed to play a role in the fertilization process and to act as a sensor for oxidative stress. Alternate names for DJ-1 include protein DJ-1, Oncogene DJ1, Parkinson disease protein 7, PARK7, and FLJ27376.

Rabbit IgG SR: human
Immunogen: synthetic peptide. The epitope recognized by A300-744A maps to a region between residue 140 and the C-terminus (residue 189) of human DJ-1 (PARK7, Parkinson Disease 7) using the numbering given in entry NP_009193.2 (GeneID 11315 ).
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IHC-00453
IHC Erklärungen der Abkürzungen ansehen.
DJ-1 appears to have a function in many biological processes. DJ-1 was first reported as an oncogene and then identified as a gene linked to Parkinson disease, a common neurodegenerative order. DJ-1 has also been observed to play a role in the fertilization process and to act as a sensor for oxidative stress. Alternate names for DJ-1 include protein DJ-1, Oncogene DJ1, Parkinson disease protein 7, PARK7, and FLJ27376.

Rabbit IgG SR: human, mouse
Immunogen: synthetic peptide. The epitope recognized by IHC-00453 maps to a region between residue 140 and the C-terminus (residue 189) of human DJ-1 (PARK7, Parkinson Disease 7) using the numbering given in entry NP_009193.2 (GeneID 11315 ).
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A300-105A
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Menin is the gene product of the putative tumor suppressor MEN1 associated with the syndrome termed multiple endocrine neoplasia type 1 that may function in the regulation of DNA synthesis or the response to DNA damage. Menin has been shown to interact with JunD, a member of the AP-1 heterodimer and inhibit transcription. Menin has also been shown to interact with Pem, FANCD2, RPA, NMMHCII-A, GFAP, vimentin, Hsp70, NfkappaB proteins, Smads, mSin3A and is part of the MLL2 and MLL1 Set1-like histone H3 K4 methyltransferase complex where it interacts directly with ASH2, Rbbp5, and WDR5. As part of the MLL complexes, menin may mediate its tumor suppressor activity via the regulation of histone methylation of HOX and CDK inhibitor genes. Alternate names for Menin are MEAI, multiple endocrine adenomatosis 1, suppressor Candidate Gene 2, and SCG2.

Rabbit IgG SR: human, mouse
Immunogen: synthetic peptide. The epitope recognized by A300-105A maps to a region between residue 575 and the C-terminus (residue 615) of human Multiple Endocrine Neoplasia 1 using the numbering given in entry NP_000235.2 (GeneID 4221).
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A300-106A
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Menin is the gene product of the putative tumor suppressor MEN1 associated with the syndrome termed multiple endocrine neoplasia type 1 that may function in the regulation of DNA synthesis or the response to DNA damage. Menin has been shown to interact with JunD, a member of the AP-1 heterodimer and inhibit transcription. Menin has also been shown to interact with Pem, FANCD2, RPA, NMMHCII-A, GFAP, vimentin, Hsp70, NfkappaB proteins, Smads, mSin3A and is part of the MLL2 and MLL1 Set1-like histone H3 K4 methyltransferase complex where it interacts directly with ASH2, Rbbp5, and WDR5. As part of the MLL complexes, menin may mediate its tumor suppressor activity via the regulation of histone methylation of HOX and CDK inhibitor genes. Alternate names for Menin are MEAI, multiple endocrine adenomatosis 1, suppressor Candidate Gene 2, and SCG2.

Goat IgG SR: human, mouse
Immunogen: synthetic peptide. The epitope recognized by A300-106A maps to a region between residue 575 and the C-terminus (residue 615) of human Multiple Endocrine Neoplasia 1 using the numbering given in entry NP_000235.2 (GeneID 4221).
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A300-106B
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Menin is the gene product of the putative tumor suppressor MEN1 associated with the syndrome termed multiple endocrine neoplasia type 1 that may function in the regulation of DNA synthesis or the response to DNA damage. Menin has been shown to interact with JunD, a member of the AP-1 heterodimer and inhibit transcription. Menin has also been shown to interact with Pem, FANCD2, RPA, NMMHCII-A, GFAP, vimentin, Hsp70, NfkappaB proteins, Smads, mSin3A and is part of the MLL2 and MLL1 Set1-like histone H3 K4 methyltransferase complex where it interacts directly with ASH2, Rbbp5, and WDR5. As part of the MLL complexes, menin may mediate its tumor suppressor activity via the regulation of histone methylation of HOX and CDK inhibitor genes. Alternate names for Menin are MEAI, multiple endocrine adenomatosis 1, suppressor Candidate Gene 2, and SCG2.

Rabbit IgG SR: human, mouse
Immunogen: synthetic peptide. The epitope recognized by A300-106B maps to a region between residue 575 and the C-terminus (residue 615) of human Multiple Endocrine Neoplasia 1 using the numbering given in entry NP_000235.2 (GeneID 4221).
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A300-114A
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Menin is the gene product of the putative tumor suppressor MEN1 associated with the syndrome termed multiple endocrine neoplasia type 1 that may function in the regulation of DNA synthesis or the response to DNA damage. Menin has been shown to interact with JunD, a member of the AP-1 heterodimer and inhibit transcription. Menin has also been shown to interact with Pem, FANCD2, RPA, NMMHCII-A, GFAP, vimentin, Hsp70, NfkappaB proteins, Smads, mSin3A and is part of the MLL2 and MLL1 Set1-like histone H3 K4 methyltransferase complex where it interacts directly with ASH2, Rbbp5, and WDR5. As part of the MLL complexes, menin may mediate its tumor suppressor activity via the regulation of histone methylation of HOX and CDK inhibitor genes. Alternate names for Menin are MEAI, multiple endocrine adenomatosis 1, suppressor Candidate Gene 2, and SCG2.

Rabbit IgG SR: human
Immunogen: synthetic peptide. The epitope recognized by A300-114A maps to a region between residue 275 and 325 of human Multiple Endocrine Neoplasia 1 using the numbering given in entry NP_000235.2 (GeneID 4221).
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A300-115A
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Menin is the gene product of the putative tumor suppressor MEN1 associated with the syndrome termed multiple endocrine neoplasia type 1 that may function in the regulation of DNA synthesis or the response to DNA damage. Menin has been shown to interact with JunD, a member of the AP-1 heterodimer and inhibit transcription. Menin has also been shown to interact with Pem, FANCD2, RPA, NMMHCII-A, GFAP, vimentin, Hsp70, NfkappaB proteins, Smads, mSin3A and is part of the MLL2 and MLL1 Set1-like histone H3 K4 methyltransferase complex where it interacts directly with ASH2, Rbbp5, and WDR5. As part of the MLL complexes, menin may mediate its tumor suppressor activity via the regulation of histone methylation of HOX and CDK inhibitor genes. Alternate names for Menin are MEAI, multiple endocrine adenomatosis 1, suppressor Candidate Gene 2, and SCG2.

Rabbit IgG SR: human
Immunogen: synthetic peptide. The epitope recognized by A300-115A maps to a region between residue 500 and 550 of human Multiple Endocrine Neoplasia 1 using the numbering given in entry NP_000235.2 (GeneID 4221).
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A310-027A
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Antibodies were affinity purified using epitopes specific to Menin immobilized on solid support.

Rabbit, Goat IgG SR: human, mouse
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A500-003A
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Menin is the gene product of the putative tumor suppressor MEN1 associated with the syndrome termed multiple endocrine neoplasia type 1 that may function in the regulation of DNA synthesis or the response to DNA damage. Menin has been shown to interact with JunD, a member of the AP-1 heterodimer and inhibit transcription. Menin has also been shown to interact with Pem, FANCD2, RPA, NMMHCII-A, GFAP, vimentin, Hsp70, NfkappaB proteins, Smads, mSin3A and is part of the MLL2 and MLL1 Set1-like histone H3 K4 methyltransferase complex where it interacts directly with ASH2, Rbbp5, and WDR5. As part of the MLL complexes, menin may mediate its tumor suppressor activity via the regulation of histone methylation of HOX and CDK inhibitor genes. Alternate names for Menin are MEAI, multiple endocrine adenomatosis 1, suppressor Candidate Gene 2, and SCG2.

Mouse IgG SR: human
Immunogen: synthetic peptide. The epitope recognized by A500-003A maps to a region between residue 575 and the C-terminus (residue 615) of human Multiple Endocrine Neoplasia 1 using the numbering given in entry NP_000235.2 (GeneID 4221).
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IHC-00572
IHC Erklärungen der Abkürzungen ansehen.
May be involved in DNA repair.

Rabbit SR: Human, Mouse
Immunogen: synthetic peptide. The epitope recognized by IHC-00572 maps to a region between residue 575 and the C-terminus (residue 615) of human Multiple Endocrine Neoplasia 1 using the numbering given in entry NP_000235.2 (GeneID 4221).
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IHC-00575
IHC Erklärungen der Abkürzungen ansehen.
May be involved in DNA repair.

Mouse IgG1 kappa SR: human
Immunogen: synthetic peptide. The epitope recognized by IHC-00575 maps to a region between residue 575 and the C-terminus (residue 615) of human Multiple Endocrine Neoplasia 1 using the numbering given in entry NP_000235.2 (GeneID 4221).
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S300-105
IP Erklärungen der Abkürzungen ansehen.
Rabbit anti-human Menin affinity purified Antibodies were coupled to agarose beads using a cyanogen bromide method.

Rabbit IgG SR: human
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A303-460A
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TNF receptor-associated factor 2 (TRAF2) regulates activation of NF-kappa-B and JNK and plays a central role in the regulation of cell survival and apoptosis. TRAF2 is required for normal antibody isotype switching from IgM to IgG. TRAF2 has E3 ubiquitin-protein ligase activity and promotes 'Lys-63'-linked ubiquitination of target proteins, such as BIRC3, RIPK1 and TICAM1. TRAF2 is an essential constituent of several E3 ubiquitin-protein ligase complexes, where it promotes the ubiquitination of target proteins by bringing them into contact with other E3 ubiquitin ligases. Alternative names for TRAF2 include E3 ubiquitin-protein ligase TRAF2, tumor necrosis factor type 2 receptor-associated protein 3, and TRAP3. [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/ Q12933]

Rabbit IgG SR: human
Immunogen: synthetic peptide. The epitope recognized by A303-460A maps to a region between residue 175 and 225 of human TNF receptor-associated factor 2 using the numbering given in entry NP_066961.2 (GeneID 7186).
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A303-461A
IP, IHC Erklärungen der Abkürzungen ansehen.
TNF receptor-associated factor 2 (TRAF2) regulates activation of NF-kappa-B and JNK and plays a central role in the regulation of cell survival and apoptosis. TRAF2 is required for normal antibody isotype switching from IgM to IgG. TRAF2 has E3 ubiquitin-protein ligase activity and promotes 'Lys-63'-linked ubiquitination of target proteins, such as BIRC3, RIPK1 and TICAM1. TRAF2 is an essential constituent of several E3 ubiquitin-protein ligase complexes, where it promotes the ubiquitination of target proteins by bringing them into contact with other E3 ubiquitin ligases. Alternative names for TRAF2 include E3 ubiquitin-protein ligase TRAF2, tumor necrosis factor type 2 receptor-associated protein 3, and TRAP3. [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/ Q12933]

Rabbit IgG SR: human
Immunogen: synthetic peptide. The epitope recognized by A303-461A maps to a region between residue 300 and 350 of human TNF receptor-associated factor 2 using the numbering given in entry NP_066961.2 (GeneID 7186).
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A311-276A
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1 each of A303-460A and A303-461A

Rabbit IgG SR: human
Immunogen: synthetic peptide
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A302-130A
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PDK1 (3-phosphoinositide-dependent kinase-1) is a serine/threonine kinase that contains a PH domain for binding of phosphatidylinositols (PtdIns). PDK1 phosphorylates PKB/AKT in response to agonist stimulation of phosphoinositide 3-kinases (PI3Ks). Stimulation of PI3Ks generates specific inositol lipids that are important for activation of PDK1. PDK1 may also be responsible for phosphorylating PKA, PKC-zeta, RPS6KA1, and RPS6KB1. Alternate names for PDK1 include hPDK and PDPK1.

Rabbit IgG SR: human, mouse
Immunogen: synthetic peptide. The epitope recognized by A302-130A maps to a region between residue 506 and 556 of human 3-phosphoinositide dependent protein kinase-1 using the numbering given in entry NP_002604.1 (GeneID 5170).
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A300-015A
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MLH1 is an integral component of the DNA mismatch repair (MMR) system that might function to recruit DNA repair proteins to the mismatch repair complex. MLH1 is located at a chromosomal location identified as an important candidate in HNPCC (hereditary nonpolyposis colorectal cancer). MLH1 is part of the BRCA1-associated genome surveillance complex (BASC). Alternate names for MLH1 include DNA mismatch repair protein Mlh1, MutL protein homolog 1, COCA2, FCC2, HNPCC, HNPCC2, and MGC5172.

Rabbit IgG SR: human
Immunogen: synthetic peptide. The epitope recognized by A300-015A maps to a region between residue 700 and the C-terminus (residue 756) of human mutL homolog 1 using the numbering given in entry NP_000240.1 (GeneID 4292).
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S300-015
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Rabbit anti-human MLH1 affinity purified Antibodies were coupled to agarose beads using a cyanogen bromide method.

Rabbit IgG SR: human
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A301-352A
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Death-associated protein (DAXX) is a multifunctional protein originally identified as a FAS-interacting protein that modulates FAS-induced cell death. The involvement of DAXX in apoptosis has been difficult to understand, and its exact function in this process has only partially been elucidated. DAXX appears to also function as a transcriptional co-repressor and has been found to associate with the SNF2 chromatin-remodeling ATPase, alpha-thalassemia syndrome protein (ATRX), and modulate transcription. Alternate names for DAXX include death domain-associated protein 6, Fas death domain-associated protein, ETS1-associated protein 1, EAP1, BING2, and DAP6.

Rabbit IgG SR: human
Immunogen: synthetic peptide. The epitope recognized by A301-352A maps to a region between residue 400 and 450 of human death-associated protein 6 using the numbering given in entry NP_001341.1 (GeneID 1616).
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A301-353A
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Death-associated protein (DAXX) is a multifunctional protein originally identified as a FAS-interacting protein that modulates FAS-induced cell death. The involvement of DAXX in apoptosis has been difficult to understand, and its exact function in this process has only partially been elucidated. DAXX appears to also function as a transcriptional co-repressor and has been found to associate with the SNF2 chromatin-remodeling ATPase, alpha-thalassemia syndrome protein (ATRX), and modulate transcription. Alternate names for DAXX include death domain-associated protein 6, Fas death domain-associated protein, ETS1-associated protein 1, EAP1, BING2, and DAP6.

Rabbit IgG SR: human
Immunogen: synthetic peptide. The epitope recognized by A301-353A maps to a region between residue 466 and 516 of human death-associated protein 6 using the numbering given in entry NP_001341.1 (GeneID 1616).
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A310-466A
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1 each of A301-352A and A301-353A

Rabbit IgG SR: human
Immunogen: synthetic peptide
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E88-143
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For the detection of Human Lactoferrin in EDTA plasma, urine, and milk. Contains sufficient components to quantitate Human Lactoferrin protein concentration in up to 40 samples, tested in duplicate. Range is 1.56-100 ng/ml.
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A300-507A
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AMP-activated protein kinase (AMPK) is a heterotrimeric protein made up of a catalytic alpha subunit, and a regulatory beta and gamma subunit. There are two distinct genes for the alpha subunit, alpha1 and alpha2. AMPK alpha 1 is the serine/threonine kinase catalytic subunit of the AMPK. AMPK is responsible for regulating fatty acid and cholesterol synthesis. AMPK is activated in response to a wide variety of metabolic stresses and switches off anabolic pathways when ATP levels are depleted. AMPK alpha 1 is also known as AMPKa1, 5-AMP-activated protein kinase catalytic subunit alpha-1, AMPK alpha-1 chain, PRKAA1, AMPK1, MGC33776, and MGC57364.

Rabbit IgG SR: human, rat, bovine
Immunogen: synthetic peptide. The epitope recognized by A300-507A maps to a region between residues 350 and 400 of human 5'-AMP-activated Protein Kinase, catalytic Alpha-1 chain using the numbering given in entry BAA36547.1 (GeneID 5562).
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IHC-00002
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AMP-activated protein kinase (AMPK) is a heterotrimeric protein made up of a catalytic alpha subunit, and a regulatory beta and gamma subunit. There are two distinct genes for the alpha subunit, alpha1 and alpha2. AMPK alpha 1 is the serine/threonine kinase catalytic subunit of the AMPK. AMPK is responsible for regulating fatty acid and cholesterol synthesis. AMPK is activated in response to a wide variety of metabolic stresses and switches off anabolic pathways when ATP levels are depleted. AMPK alpha 1 is also known as AMPKa1, 5-AMP-activated protein kinase catalytic subunit alpha-1, AMPK alpha-1 chain, PRKAA1, AMPK1, MGC33776, and MGC57364.

Rabbit IgG SR: human, mouse
Immunogen: synthetic peptide. The epitope recognized by IHC-00002 maps to a region between residue 350 and 400 of human 5'-AMP-activated Protein Kinase, catalytic Alpha-1 chain using the numbering given in entry BAA36547.1 (GeneID 5562).
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S300-507
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Rabbit anti-human AMPK alpha 1 affinity purified Antibodies were coupled to agarose beads using a cyanogen bromide method.

Rabbit IgG SR: human, rat, bovine
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A302-858A
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Rabbit IgG SR: human
Immunogen: Synthetic peptide. The epitope recognized by A302-858A maps to a region between residue 285 and 335 of human Fas (TNF receptor superfamily, member 6) using the numbering given in entry NP_000034.1 (GeneID 355).
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A301-818A
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ZAP-70 (zeta associated protein 70) is a tyrosine kinase of the Src family of tyrosine kinases. It was initially identified as a partner of the zeta chain of the CD3 complex associated to the T-cell receptor on T-lymphocytes. ZAP-70 shares homology with spleen-tyrosine kinase (Syk), a kinase involved in B-cell activation. Both ZAP-70 and Syk have been shown to be crucial to B- and T-lymphocyte development. In T-cells ZAP-70 functions to transduce the signaling cascade activated by T-cell receptor engagement and activation. ZAP-70 is also known as ZAP70, Syk-related tyrosine kinase, SRK, 70 kDa zeta-associated protein, ant STD.

Rabbit IgG SR: human
Immunogen: synthetic peptide. The epitope recognized by A301-818A maps to a region between residue 564 and 614 of human zeta-chain (TCR) associated protein kinase 70kDa using the numbering given in entry NP_001070.2 (GeneID 7535).
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A302-007A
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ZAP-70 (zeta associated protein 70) is a tyrosine kinase of the Src family of tyrosine kinases. It was initially identified as a partner of the zeta chain of the CD3 complex associated to the T-cell receptor on T-lymphocytes. ZAP-70 shares homology with spleen-tyrosine kinase (Syk), a kinase involved in B-cell activation. Both ZAP-70 and Syk have been shown to be crucial to B- and T-lymphocyte development. In T-cells ZAP-70 functions to transduce the signaling cascade activated by T-cell receptor engagement and activation. ZAP-70 is also known as ZAP70, Syk-related tyrosine kinase, SRK, 70 kDa zeta-associated protein, ant STD.

Rabbit IgG SR: human
Immunogen: synthetic phospho-peptide. The epitope recognized by A302-007A maps to a region including tyrosine 319 (when it is phosphorylated) of human zeta-chain (TCR) associated protein kinase 70kDa using the numbering given in entry NP_001070.2 (GeneID 7535).
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A302-008A
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ZAP-70 (zeta associated protein 70) is a tyrosine kinase of the Src family of tyrosine kinases. It was initially identified as a partner of the zeta chain of the CD3 complex associated to the T-cell receptor on T-lymphocytes. ZAP-70 shares homology with spleen-tyrosine kinase (Syk), a kinase involved in B-cell activation. Both ZAP-70 and Syk have been shown to be crucial to B- and T-lymphocyte development. In T-cells ZAP-70 functions to transduce the signaling cascade activated by T-cell receptor engagement and activation. ZAP-70 is also known as ZAP70, Syk-related tyrosine kinase, SRK, 70 kDa zeta-associated protein, ant STD.

Rabbit IgG SR: human
Immunogen: synthetic phospho-peptide. The epitope recognized by A302-008A maps to a region including tyrosine 493 (when it is phosphorylated) of human zeta-chain (TCR) associated protein kinase 70kDa using the numbering given in entry NP_001070.2 (GeneID 7535).
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A302-009A
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ZAP-70 (zeta associated protein 70) is a tyrosine kinase of the Src family of tyrosine kinases. It was initially identified as a partner of the zeta chain of the CD3 complex associated to the T-cell receptor on T-lymphocytes. ZAP-70 shares homology with spleen-tyrosine kinase (Syk), a kinase involved in B-cell activation. Both ZAP-70 and Syk have been shown to be crucial to B- and T-lymphocyte development. In T-cells ZAP-70 functions to transduce the signaling cascade activated by T-cell receptor engagement and activation. ZAP-70 is also known as ZAP70, Syk-related tyrosine kinase, SRK, 70 kDa zeta-associated protein, ant STD.

Rabbit IgG SR: human
Immunogen: synthetic phospho-peptide. The epitope recognized by A302-009A maps to a region including tyrosines 493 and 494 (when they are phosphorylated) of human zeta-chain (TCR) associated protein kinase 70kDa using the numbering given in entry NP_001070.2 (GeneI
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A300-765A
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E2F1 is a member of the E2F family of transcription factors. E2F is an activating member that binds DNA at the E2 recognition site in the promoters of genes involved in cell cycle regulation or DNA replication. E2F1 is regulated through its interaction with the pRb tumor suppressor. Alternate names for E2F1 include transcription factor E2F1, E2F-1, retinoblastoma-binding protein 3, RBBP-3, PRB-binding protein E2F1, PBR3, retinoblastoma-associated protein 1, RBAP-1, and RBP3.

Rabbit IgG SR: human
Immunogen: synthetic peptide. The epitope recognized by A300-765A maps to a region between residue 300 and 350 of human E2F Transcription Factor 1 using the numbering given in entry NP_005216.1 (GeneID 1869).
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A300-766A
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E2F1 is a member of the E2F family of transcription factors. E2F is an activating member that binds DNA at the E2 recognition site in the promoters of genes involved in cell cycle regulation or DNA replication. E2F1 is regulated through its interaction with the pRb tumor suppressor. Alternate names for E2F1 include transcription factor E2F1, E2F-1, retinoblastoma-binding protein 3, RBBP-3, PRB-binding protein E2F1, PBR3, retinoblastoma-associated protein 1, RBAP-1, and RBP3.

Rabbit IgG SR: human
Immunogen: synthetic peptide. The epitope recognized by A300-766A maps to a region between residue 387 and 437 of human E2F Transcription Factor 1 using the numbering given in entry NP_005216.1 (GeneID 1869).
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A310-236A
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Antibodies were affinity purified using epitopes specific to E2F1 immobilized on solid support.

Rabbit IgG SR: human
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IHC-00459
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E2F1 is a member of the E2F family of transcription factors. E2F is an activating member that binds DNA at the E2 recognition site in the promoters of genes involved in cell cycle regulation or DNA replication. E2F1 is regulated through its interaction with the pRb tumor suppressor. Alternate names for E2F1 include transcription factor E2F1, E2F-1, retinoblastoma-binding protein 3, RBBP-3, PRB-binding protein E2F1, PBR3, retinoblastoma-associated protein 1, RBAP-1, and RBP3.

Rabbit IgG SR: human
Immunogen: synthetic peptide. The epitope recognized by ihc-00459 maps to a region between residue 300 and 350 of human E2F Transcription Factor 1 using the numbering given in entry NP_005216.1 (GeneID 1869).
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A300-501A
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Eukaryotic translation initiation factor 4E-binding protein 1 (4EBP1) binds directly to eIF4E to inhibit complex assembly for translation initiation. 4EBP1 is part of a family of translation repressor proteins. 4EBP1 is directly phosphorylated by the mTORC1 complex during growth factor stimulation of cells. Phosphorylation of 4EBP1 causes its release from eIF4E to allow translation to proceed. 4EBP1 is also called eIF4E-binding protein, phosphorylated heat-and-acid-stable protein regulated by insulin 1, PHAS-I, EIF4EBP1, BP-1, and MGC4316.

Rabbit IgG SR: human, swine, mouse, rat
Immunogen: synthetic peptide. The epitope recognized by A300-501A maps to a region between residue 75 and the C-terminus (residue 118) of human eukaryotic translation initiation factor 4E binding protein 1 using the numbering given in entry NP_004086.1 (GeneID 1978)
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IHC-00133
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Eukaryotic translation initiation factor 4E-binding protein 1 (4EBP1) binds directly to eIF4E to inhibit complex assembly for translation initiation. 4EBP1 is part of a family of translation repressor proteins. 4EBP1 is directly phosphorylated by the mTORC1 complex during growth factor stimulation of cells. Phosphorylation of 4EBP1 causes its release from eIF4E to allow translation to proceed. 4EBP1 is also called eIF4E-binding protein, phosphorylated heat-and-acid-stable protein regulated by insulin 1, PHAS-I, EIF4EBP1, BP-1, and MGC4316.

Rabbit IgG SR: human
Immunogen: synthetic peptide. The epitope recognized by IHC-00133 maps to a region between residues 75 and the C-terminus (residue 118) of human eukaryotic translation initiation factor 4E binding protein 1 using the numbering given in entry NP_004086.1 (GeneID 1978
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A302-337A
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The cbl oncogene was first identified as part of a transforming retrovirus which induces mouse pre-B and pro-B cell lymphomas. As an adaptor protein for receptor protein-tyrosine kinases, it positively regulates receptor protein-tyrosine kinase ubiquitination in a manner dependent upon its variant SH2 and RING finger domains. Ubiquitination of receptor protein-tyrosine kinases terminates signaling by marking active receptors for degradation. Alternative names for c-Cbl include Casitas B-lineage lymphoma proto-oncogene, Cas-Br-M ectropic retroviral transforming sequence, RING finger protein 55, proto-oncogene c-CBL, CBL2, and RNF55.

Rabbit IgG SR: human
Immunogen: synthetic peptide. The epitope recognized by A302-337A maps to a region between residue 575 and 625 of human Casitas B-lineage lymphoma proto-oncogene using the numbering given in entry NP_005179.2 (GeneID 867).
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A302-338A
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The cbl oncogene was first identified as part of a transforming retrovirus which induces mouse pre-B and pro-B cell lymphomas. As an adaptor protein for receptor protein-tyrosine kinases, it positively regulates receptor protein-tyrosine kinase ubiquitination in a manner dependent upon its variant SH2 and RING finger domains. Ubiquitination of receptor protein-tyrosine kinases terminates signaling by marking active receptors for degradation. Alternative names for c-Cbl include Casitas B-lineage lymphoma proto-oncogene, Cas-Br-M ectropic retroviral transforming sequence, RING finger protein 55, proto-oncogene c-CBL, CBL2, and RNF55.

Rabbit IgG SR: human
Immunogen: synthetic peptide. The epitope recognized by A302-338A maps to a region between residue 675 and 725 of human Casitas B-lineage lymphoma proto-oncogene using the numbering given in entry NP_005179.2 (GeneID 867).
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A310-847A
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1 each of A302-337A and A302-338A

Rabbit IgG SR: human
Immunogen: synthetic peptide
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A303-413A
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Stromal interaction molecule 1 (STIM1) a type 1 transmembrane protein that mediates Ca2 influx after depletion of intracellular Ca2 stores by gating of store-operated Ca2 influx channels (SOCs). It is one of several genes located in the imprinted gene domain of 11p15.5, an important tumor-suppressor gene region. Alterations in this region have been associated with the Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocrotical carcinoma, and lung, ovarian, and breast cancer. This gene may play a role in malignancies and disease that involve this region, as well as early hematopoiesis, by mediating attachment to stromal cells. Alternative names for STIM1 include GOK1, and STIM1L. [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/ Q13586]

Rabbit IgG SR: human
Immunogen: synthetic peptide. The epitope recognized by A303-413A maps to a region between residue 550 and 600 of human Stromal Interaction Molecule 1 using the numbering given in entry NP_003147.2 (GeneID 6786).
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A303-414A
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Stromal interaction molecule 1 (STIM1) a type 1 transmembrane protein that mediates Ca2 influx after depletion of intracellular Ca2 stores by gating of store-operated Ca2 influx channels (SOCs). It is one of several genes located in the imprinted gene domain of 11p15.5, an important tumor-suppressor gene region. Alterations in this region have been associated with the Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocrotical carcinoma, and lung, ovarian, and breast cancer. This gene may play a role in malignancies and disease that involve this region, as well as early hematopoiesis, by mediating attachment to stromal cells. Alternative names for STIM1 include GOK1, and STIM1L. [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/ Q13586]

Rabbit IgG SR: human
Immunogen: synthetic peptide. The epitope recognized by A303-414A maps to a region between residue 635 and 685 of human Stromal Interaction Molecule 1 using the numbering given in entry NP_003147.2 (GeneID 6786).
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A311-259A
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1 each of A303-413A and A303-414A

Rabbit IgG SR: human
Immunogen: synthetic peptide
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A303-872A
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CD44 is a cell-surface glycoprotein involved in cell-cell interactions, cell adhesion and migration. It is a receptor for hyaluronic acid (HA) and can also interact with other ligands, such as osteopontin, collagens, and matrix metalloproteinases (MMPs). CD44 participates in a wide variety of cellular functions including lymphocyte activation, recirculation and homing, hematopoiesis, and tumor metastasis [taken from NCBI Entrez Gene (Gene ID: 960)].

Rabbit IgG SR: human
Immunogen: Synthetic peptide. The epitope recognized by A303-872A maps to a region between residue 692 and 742 of human Cell Surface Glycoprotein CD44 using the numbering given in entry NP_000601.3 (GeneID 960).
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A300-133A
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Specificity protein 1 (Sp1) is the original member of the Sp1-like/KLF family of zinc-finger transcription factors that binds GC-rich DNA elements to regulate transcription of genes involved in a variety of cellular functions. Sp-1 interacts with coactivators such as p300/CBP, TAFII130, and CRSP.

Rabbit IgG SR: human
Immunogen: synthetic peptide. The epitope recognized by A300-133A maps to a region between residues 700 and 740 using the numbering given in entry XP_028606.4 (GeneID 6667).
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A300-134A
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Specificity protein 1 (Sp1) is the original member of the Sp1-like/KLF family of zinc-finger transcription factors that binds GC-rich DNA elements to regulate transcription of genes involved in a variety of cellular functions. Sp-1 interacts with coactivators such as p300/CBP, TAFII130, and CRSP.

Rabbit IgG SR: human
Immunogen: synthetic peptide. The epitope recognized by A300-134A maps to a region between residue 750 and the C-terminus (residue 785) using the numbering given in entry XP_028606.4 (GeneID 6667).
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A303-944A
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Specificity protein 1 (Sp1) is the original member of the Sp1-like/KLF family of zinc-finger transcription factors that binds GC-rich DNA elements to regulate transcription of genes involved in a variety of cellular functions. Sp-1 interacts with coactivators such as p300/CBP, TAFII130, and CRSP.

Goat IgG SR: human, mouse
Immunogen: Synthetic peptide. The epitope recognized by A303-944A maps to a region between residue 735 to 785 of human Sp1 Transcription Factor using the numbering given in entry NP_612482.2 (GeneID 6667).
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A310-033A
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Antibodies were affinity purified using epitopes specific to Sp1 immobilized on solid support.

Rabbit IgG SR: human
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IHC-00208
IHC Erklärungen der Abkürzungen ansehen.
Specificity protein 1 (Sp1) is the original member of the Sp1-like/KLF family of zinc-finger transcription factors that binds GC-rich DNA elements to regulate transcription of genes involved in a variety of cellular functions. Sp-1 interacts with coactivators such as p300/CBP, TAFII130, and CRSP.

Rabbit IgG SR: human
Immunogen: synthetic peptide. The epitope recognized by IHC-00208 maps to a region between residues 750 and the C-terminus (residue 785) of human Sp1 using the numbering given in entry XP_028606.4 (GeneID 6667).
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A302-024A
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Ephrin type-A receptor 2 (EphA2) is a member of the Eph family of tyrosine kinase receptors. Eph receptors have been shown to play a critical role in the development of the nervous system, where they regulate patterning during neural development. The ligands for Eph receptors are ephrins. Ephrin receptors and ligands have been found to be frequently overexpressed in a wide variety of cancers. Contrary to the usual finding that the oncogenic properties of tyrosine kinase receptors are promoted by the autophosphorylation of the receptor, it is the dephosphorylation of EphA2 that is associated with its oncogenic activity. The major study of EphA2 has been in relation to its contribution to malignancy and the possibility of targeting it in cancer therapy. Alternative names for EphA2 include tyrosine-protein kinase receptor ECK, epithelial cell kinase, and ECK.

Rabbit IgG SR: human
Immunogen: synthetic peptide. The epitope recognized by A302-024A maps to a region between residue 150 and 200 of human ephrin receptor A2 using the numbering given in entry NP_004422.2 (GeneID 1969).
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A302-025A
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Ephrin type-A receptor 2 (EphA2) is a member of the Eph family of tyrosine kinase receptors. Eph receptors have been shown to play a critical role in the development of the nervous system, where they regulate patterning during neural development. The ligands for Eph receptors are ephrins. Ephrin receptors and ligands have been found to be frequently overexpressed in a wide variety of cancers. Contrary to the usual finding that the oncogenic properties of tyrosine kinase receptors are promoted by the autophosphorylation of the receptor, it is the dephosphorylation of EphA2 that is associated with its oncogenic activity. The major study of EphA2 has been in relation to its contribution to malignancy and the possibility of targeting it in cancer therapy. Alternative names for EphA2 include tyrosine-protein kinase receptor ECK, epithelial cell kinase, and ECK.

Rabbit IgG SR: human
Immunogen: synthetic peptide. The epitope recognized by A302-025A maps to a region between residue 926 and 976 of human ephrin receptor A2 using the numbering given in entry NP_004422.2 (GeneID 1969).
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A310-714A
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1 each of A302-024A and A302-025A

Rabbit IgG SR: human
Immunogen: synthetic peptide
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IHC-00427
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Ephrin type-A receptor 2 (EphA2) is a member of the Eph family of tyrosine kinase receptors. Eph receptors have been shown to play a critical role in the development of the nervous system, where they regulate patterning during neural development. The ligands for Eph receptors are ephrins. Ephrin receptors and ligands have been found to be frequently overexpressed in a wide variety of cancers. Contrary to the usual finding that the oncogenic properties of tyrosine kinase receptors are promoted by the autophosphorylation of the receptor, it is the dephosphorylation of EphA2 that is associated with its oncogenic activity. The major study of EphA2 has been in relation to its contribution to malignancy and the possibility of targeting it in cancer therapy. Alternative names for EphA2 include tyrosine-protein kinase receptor ECK, epithelial cell kinase, and ECK.

Rabbit IgG SR: human
Immunogen: synthetic peptide. The epitope recognized by IHC-00427 maps to a region between residue 150 and 200 of human ephrin receptor A2 using the numbering given in entry NP_004422.2 (GeneID 1969).
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A301-153A
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eIF4E is a component of the EIF4F initiation complex (eIF4A, eIF4E, eIF4G) that is involved in the processes of mRNA cap recognition, poly (A) binding, and the recruitment of mRNA to the ribosome during protein synthesis. eIF4E plays a role in binding the 5 cap of the mRNA for translation initiation. Alternate names for eI4E include eukaryotic translation initiation factor 4E, eIF-4E, mRNA cap-binding protein, eIF-4F 25 kDa subunit, EIF4E, EIF4EL1, EIF4E1, and MGC111573.

Rabbit IgG SR: human
Immunogen: synthetic peptide. The epitope recognized by A301-153A maps to a region between residue 1 and 50 of human eukaryotic translation initiation factor 4E using the numbering given in entry NP_001959.1 (GeneID 1977).
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A301-154A
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eIF4E is a component of the EIF4F initiation complex (eIF4A, eIF4E, eIF4G) that is involved in the processes of mRNA cap recognition, poly (A) binding, and the recruitment of mRNA to the ribosome during protein synthesis. eIF4E plays a role in binding the 5 cap of the mRNA for translation initiation. Alternate names for eI4E include eukaryotic translation initiation factor 4E, eIF-4E, mRNA cap-binding protein, eIF-4F 25 kDa subunit, EIF4E, EIF4EL1, EIF4E1, and MGC111573.

Rabbit IgG SR: human, mouse
Immunogen: synthetic peptide. The epitope recognized by A301-154A maps to a region between residue 167 and 217 of human eukaryotic translation initiation factor 4E using the numbering given in entry NP_001959.1 (GeneID 1977).
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A310-383A
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Antibodies were affinity purified using epitopes specific to eIF4E immobilized on solid support.

Rabbit IgG SR: human, mouse
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A303-659A
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Pyruvate Kinase M2 (PKM2) is a glycolytic enzyme that catalyzes the transfer of a phosphoryl group from phosphoenolpyruvate (PEP) to ADP, generating ATP. The ratio between the highly active tetrameric form and nearly inactive dimeric form determines whether glucose carbons are channeled to biosynthetic processes or used for glycolytic ATP production. The transition between the 2 forms contributes to the control of glycolysis and is important for tumor cell proliferation and survival. PKM2 also stimulates POU5F1-mediated transcriptional activation, and plays a general role in caspase independent cell death of tumor cells. Alternative names for PKM2 include pyruvate kinase isozymes M1/M2, cytosolic thyroid hormone-binding protein, CTHBP, opa-interacting protein 3, OIP-3, pyruvate kinase 2/3, pyruvate kinase muscle isozyme, thyroid hormone binding protein 1, THBP1, tumore M2-PK, p58, OIP3, PK3, PKM, and TCB. [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/ P14618]

Rabbit IgG SR: human
Immunogen: Synthetic peptide. The epitope recognized by A303-659A maps to a region between residue 1 and 50 of human Pyruvate Kinase Isozymes M1/M2 using the numbering given in entry NP_002645.3 (GeneID 5315).
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A303-660A
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Pyruvate Kinase M2 (PKM2) is a glycolytic enzyme that catalyzes the transfer of a phosphoryl group from phosphoenolpyruvate (PEP) to ADP, generating ATP. The ratio between the highly active tetrameric form and nearly inactive dimeric form determines whether glucose carbons are channeled to biosynthetic processes or used for glycolytic ATP production. The transition between the 2 forms contributes to the control of glycolysis and is important for tumor cell proliferation and survival. PKM2 also stimulates POU5F1-mediated transcriptional activation, and plays a general role in caspase independent cell death of tumor cells. Alternative names for PKM2 include pyruvate kinase isozymes M1/M2, cytosolic thyroid hormone-binding protein, CTHBP, opa-interacting protein 3, OIP-3, pyruvate kinase 2/3, pyruvate kinase muscle isozyme, thyroid hormone binding protein 1, THBP1, tumore M2-PK, p58, OIP3, PK3, PKM, and TCB. [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/ P14618]

Rabbit IgG SR: human, mouse
Immunogen: Synthetic peptide. The epitope recognized by A303-660A maps to a region between residue 481 and 531 of human Pyruvate Kinase Isozymes M1/M2 using the numbering given in entry NP_002645.3 (GeneID 5315).
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A311-342A
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1 each of A303-659A and A303-660A

Rabbit IgG SR: human, mouse
Immunogen: Synthetic peptide. Antibodies were affinity purified using epitopes specific to PKM2 immobilized on solid support.
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A300-276A
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PCNA (Proliferating Cell Nuclear Antigen) was first identified as a factor expressed in the nuclei of replicating cells. PCNA plays a role in both DNA synthesis and repair. PCNA functions as a processivity factor for DNA polymerase by acting as a DNA clamp that tethers the polymerase catalytic units to the DNA template. The structure of PCNA is that of a trimeric ring that encircles and slides along replicating DNA. PCNA interacts with and is regulated by several proteins involved in cell cycle control and check point processes.

Rabbit IgG SR: human
Immunogen: synthetic peptide. The epitope recognized by A300-276A maps to a region between residues 75 and 125 of human proliferating cell nuclear antigen using the numbering given in SwissProt entry P12004 (GeneID 5111).
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A300-276B
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PCNA (Proliferating Cell Nuclear Antigen) was first identified as a factor expressed in the nuclei of replicating cells. PCNA plays a role in both DNA synthesis and repair. PCNA functions as a processivity factor for DNA polymerase by acting as a DNA clamp that tethers the polymerase catalytic units to the DNA template. The structure of PCNA is that of a trimeric ring that encircles and slides along replicating DNA. PCNA interacts with and is regulated by several proteins involved in cell cycle control and check point processes.

Rabbit IgG SR: human
Immunogen: synthetic peptide. The epitope recognized by A300-276B maps to a region between residues 75 and 125 of human proliferating cell nuclear antigen using the numbering given in SwissProt entry P12004 (GeneID 5111).
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A300-277A
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PCNA (Proliferating Cell Nuclear Antigen) was first identified as a factor expressed in the nuclei of replicating cells. PCNA plays a role in both DNA synthesis and repair. PCNA functions as a processivity factor for DNA polymerase by acting as a DNA clamp that tethers the polymerase catalytic units to the DNA template. The structure of PCNA is that of a trimeric ring that encircles and slides along replicating DNA. PCNA interacts with and is regulated by several proteins involved in cell cycle control and check point processes.

Rabbit IgG SR: human
Immunogen: synthetic peptide. The epitope recognized by A300-276A maps to a region between residue 225 and the C-terminus (residue 261) of human proliferating cell nuclear antigen using the numbering given in SwissProt entry P12004 (GeneID 5111).
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A300-277B
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PCNA (Proliferating Cell Nuclear Antigen) was first identified as a factor expressed in the nuclei of replicating cells. PCNA plays a role in both DNA synthesis and repair. PCNA functions as a processivity factor for DNA polymerase by acting as a DNA clamp that tethers the polymerase catalytic units to the DNA template. The structure of PCNA is that of a trimeric ring that encircles and slides along replicating DNA. PCNA interacts with and is regulated by several proteins involved in cell cycle control and check point processes.

Rabbit IgG SR: human
Immunogen: synthetic peptide. The epitope recognized by A300-277B maps to a region between residue 225 and the C-terminus (residue 261) of human proliferating cell nuclear antigen using the numbering given in SwissProt entry P12004 (GeneID 5111).
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A310-076A
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Antibodies were affinity purified using epitopes specific to PCNA immobilized on solid support.

Rabbit IgG SR: human
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IHC-00012
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PCNA (Proliferating Cell Nuclear Antigen) was first identified as a factor expressed in the nuclei of replicating cells. PCNA plays a role in both DNA synthesis and repair. PCNA functions as a processivity factor for DNA polymerase by acting as a DNA clamp that tethers the polymerase catalytic units to the DNA template. The structure of PCNA is that of a trimeric ring that encircles and slides along replicating DNA. PCNA interacts with and is regulated by several proteins involved in cell cycle control and check point processes.

Rabbit IgG SR: human, mouse
Immunogen: synthetic peptide. The epitope recognized by IHC-00012 maps to a region between residue 225 and the C-terminus (residue 261) of human proliferating cell nuclear antigen using the numbering given in entry NP 002583.1 (GeneID 5111).
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IHC-00219
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PCNA (Proliferating Cell Nuclear Antigen) was first identified as a factor expressed in the nuclei of replicating cells. PCNA plays a role in both DNA synthesis and repair. PCNA functions as a processivity factor for DNA polymerase by acting as a DNA clamp that tethers the polymerase catalytic units to the DNA template. The structure of PCNA is that of a trimeric ring that encircles and slides along replicating DNA. PCNA interacts with and is regulated by several proteins involved in cell cycle control and check point processes.

Rabbit IgG SR: human
Immunogen: synthetic peptide. Immunogen for IHC-00219 was a phosphorylated synthetic peptide, which represented a portion of human proliferating cell nuclear antigen (GeneID 5111) around tyrosine 211 according to the numbering given inentry NP_002583.1.
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A300-075A
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