18 products were found matching "Cay81025.1"!

1,3-PBIT is a potent inhibitor of iNOS with a Ki of 47 nM compared to Ki values for eNOS and nNOS are 9 and 0.25 µM, respectively, for the purified human enzymes. Its inhibition in whole cells is greatly diminished, presumably to poor membrane permeability.Formal Name:...

NS 2028 is a specific inhibitor of soluble guanylyl cyclase. It inhibits purified bovine lung guanylyl cyclase in a concentration dependent and irreversible manner with IC50 values of 30 and 200 nM for basal and NO-stimulated enzymes, respectively. S-nitroso-glutathione-enhanced guanylyl cyclase activity in mouse...

(-)-Perillyl alcohol is a monoterpene alcohol that has been found in lavender essential oil and has diverse biological activities. It reduces production of hydroperoxidienes and thiobarbituric acid reactive substances (TBARS) in vitro in a concentration-dependent manner. (-)-Perillyl alcohol inhibits PANC-1...

DPTA NONOate is a NO donor. It spontaneously dissociates in a pH-dependent, first-order process with a half-life of three hours and five hours at 37°C and 22-25°C, pH 7.4, respectively, to liberate 2 moles of NO per mole of parent compound.Formal Name:...

17-phenyl trinor Prostaglandin F2alpha (17-phenyl trinor PGF2alpha) is a metabolically stable analog of PGF2alpha and is a potent agonist for the FP receptor. It binds to the FP receptor on ovine luteal cells with a relative potency of 756% compared to that of PGF2alpha. At the rat recombinant FP receptor expressed...

AAT-008 is an orally bioavailable and potent antagonist of the prostaglandin E2 (PGE2) receptor subtype 4 (EP4, IC50 = 16.3 nM in a human EP4 functional assay). It is selective for EP4 with IC50 values of 2.4, 1,890, >20,000, and >20,000 nM for binding to human recombinant EP4, EP2, EP1, and EP3, respectively....

Picrotin is a natural picrotoxane that antagonizes glycine receptors (GlyRs, IC50s = 57 and 117 µM for alpha1 and alpha2 homodimeric GlyRs, respectively). It also inhibits alpha3 homodimeric GlyRs. Picrotin is inactive in inhibiting gamma-aminobutyric acid (GABA) type A and type C receptors. Picrotin occurs in the...

MM-11253 is a synthetic, conformationally restricted retinoid that acts as a selective antagonist of retinoic acid receptor gamma (RARgamma). It dose-dependently blocks the ability of RARgamma-selective agonists, but not retinoic acid (all-trans retinoic acid, Cay-11017), to inhibit the growth of oral squamous cell...

Photoswitchable PAD inhibitor is a photoactivated protein arginine deiminase (PAD) inhibitor and a derivative of BB-Cl-amidine (Cay-17079) that contains an azobenzene photoswitch allowing optical control of PAD activity. Without photoactivation, it is a weak inhibitor of PAD2 (IC50 = >100 µM) and is less potent than...

GLPG0974 is an antagonist of free fatty acid receptor 2 (FFAR2/GPR43, IC50 = 9 nM). It is selective for FFAR2 over FFAR3 at concentrations up to 30 µM and over a panel of 55 receptors, ion channels, and transporters at 10 µM. GLPG0974 inhibits acetate-induced migration of isolated human neutrophils in buffer or...

Trimetazidine-d8 is intended for use as an internal standard for the quantification of trimetazidine by GC- or LC-MS. Trimetazidine is a cardioprotective agent. It decreases ischemia-reperfusion injury-induced pyroptosis in H9c2 rat cardiomyocytes when used at concentrations ranging from 5 to 100 µM. In vivo,...

tetranor-Prostaglandin E metabolite-d6 (tetranor-PGEM-d6) is intended for use as an internal standard for the quantification of tetranor-PGEM (Cay-14840) by GC- or LC-MS. tetranor-PGEM is the major urinary metabolite of PGE2 (Cay-14010). Urine levels of tetranor-PGEM are increased in patients with diabetic...