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Anti-Jumonji Domain Containing 2A (JMJD2A, JHDM3A, KIAA0

ART NR.: J7876-45.50 (50 µg)

Hersteller: USBio


Anwendungen: WB

Format: affinity purified

Klon: 8C200

Wirt: Mouse

Isotyp: IgG2a

Reaktivität: human

Immunogen: Recombinant hum

Lagerung: -20°C

Versand: +4°C

UniProt ID: O75164 | Suche mit UniProt ID

Gene ID: Gene ID 9682 | Suche mit Gene ID

KEGG ID: K06709 | Suche mit KEGG ID

Schlagworte: Anti-KDM4A, EC=1.14.11.-, Anti-Lysine-specific demethylase 4A, Anti-Jumonji domain-containing protein 2A, Anti-JmjC domain-containing histone demethylation protein 3A


50 µg

378 €

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Bemerkungen: Histone demethylase that specifically demethylates 'Lys-9' and 'Lys-36' residues of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-4', H3 'Lys-27' nor H4 'Lys-20'. Demethylates trimethylated H3 'Lys-9' and H3 'Lys-36' residue, while it has no activity on mono- and dimethylated residues. Demethylation of Lys residue generates formaldehyde and succinate. Participates in transcriptional repression of ASCL2 and E2F-responsive promoters via the recruitment of histone deacetylases and NCOR1, respectively. [The UniProt Consortium]

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