8 products were found matching "Cay90270-%25"!

17(R)-Resolvin D1 (17(R)-RvD1) is an aspirin-triggered epimer of RvD1 (Cay-10012554) that reduces human polymorphonuclear leukocyte transendothelial migration, the earliest event in acute inflammation, with equipotency to RvD1 (EC50 = ~30 nM). 17(R)-RvD1 exhibits a dose-dependent reduction in leukocyte infiltration...

Methylatropine is an antagonist of muscarinic acetylcholine receptors (IC50 = 12008). It reduces acetylcholine-induced decreases in blood pressure in rats when administered intravenously with an ED50 value of 5.5 µg/kg. Methylatropine reduces salivation, induces mydriasis, and increases heart rate in dogs.Formal...

Isoastragaloside I is a saponin that has been found in A. membranaceus and has diverse biological activities. It inhibits LPS-induced production of nitric oxide (NO), TNF-alpha, and IL-1beta, as well as inhibits NF-kappaB phosphorylation in BV-2 microglia when used at concentrations ranging from 25 to 100 µM....

This gene encodes mitogen-activated protein kinase kinase kinase 14, which is a serine/threonine protein-kinase. This kinase binds to TRAF2 and stimulates NF-kappaB activity. It shares sequence similarity with several other MAPKK kinases. It participates in an NF-kappaB-inducing signalling cascade common to...

Cytochrome P450 3A4 inducing anti-epileptic drug. It Increases metabolism of CPT11 and Paclitaxel, and many tyrosine kinase inhibitors. Used in the treatment of shooting neuralgic pain attacks.

Docosatrienoic acid is a rare omega-3 fatty acid not readily detected in normal phospholipid PUFA pools. It is a polyunsaturated version of the fatty acid docosanoic acid (Cay-9000338). Docosatrienoic acid inhibits [3H]-LTB4 binding to pig neutrophils at a concentration of 5 µM. It also dose-dependently inhibits the...

R-1 methanandamide is a potent cannabinoid (CB) receptor 1 agonist in the methanandamide series. It is selective for CB1 over CB2 receptors with Ki values ranging from 17.9 to 28.3 and 815 to 868 nM, respectively.{7912, 10685} R-1 methanandamide is more potent than arachidonoyl ethanolamide (AEA, Cay-90050). In...

Amiselimod is a prodrug form of the sphingosine-1-phosphate receptor 1 (S1P1) antagonist amiselimod phosphate (amiselimod-P). In vivo, amiselimod (0.3 mg/kg per day) inhibits the development of chronic colitis induced by adoptive transfer of CD4+CD45RBhigh T cells in mice.Formal Name:...