14 products were found matching "Cay90200"!

5,8,11-ETI is a nonselective inhibitor of lipoxygenases. It inhibits 12-LO in human platelets with an ID50 value of 24 µM. 5,8,11-ETI also inhibits A23187 and L-cysteine induced LTC4 biosynthesis in mouse mastocytoma cells with an ID50 value of 5 µM. At higher concentrations, 5,8,11-ETI also inhibits cyclooxygenases...

gamma-Linolenic acid (GLA) is an omega-6 fatty acid which can be elongated to arachidonic acid for endogenous eicosanoid synthesis. It is a weak LTB4 receptor antagonist, inhibiting [3H]-LTB4 binding to porcine neutrophil membranes with a Ki of 1 µM. GLA produces 53% inhibition at a 1 mg/kg dose in an in vivo model...

5,6-dehydro Arachidonic acid is an analog of arachidonic acid with an acetylene in the 5,6 position. It inhibits 5-LO in rat basophilic leukemia cells, with a Ki value of 15 µM. In guinea pig leukocytes, 5-LO is inhibited by 5,6-dehydro arachidonic acid with an IC50 value of 10 µM.Formal Name:...

Oleic acid is a monounsaturated fatty acid and a major component of membrane phospholipids that has been found in human plasma, cell membranes, and adipose tissue. It contributes approximately 17% of the total fatty acids esterified to phosphatidylcholine, the major phospholipid class in porcine platelets. Oleic...

alpha-Linolenic acid (ALA) is an essential omega-3 polyunsaturated fatty acid found in plants. It is converted to the longer-chain fatty acids eicosapentaenoic (Cay-90110, Cay-90110.1, Cay-21908), docosapentaenoic (Cay-90165, Cay-21907), and docosahexaenoic acid (Cay-90310). It is also catabolized via fatty acid...

Dihomo-gamma-Linolenic Acid (DGLA, 20:3), an elongation product of gamma-linolenic acid (18:3), is rapidly metabolized by fatty acid desaturases to produce arachidonic acid (20:4). DGLA is metabolized through the cyclooxygenase pathway to produce 1-series prostaglandins, including PGE1. In mice, DGLA supplementation...

Elaidic acid is a monounsaturated trans fatty acid and the 9-trans isomer of oleic acid (Cay-90260, Cay-24659) that has been found in partially hydrogenated cooking oils. It reduces HHT and HETE formation and increases synthesis of prostaglandin E2 (PGE2, Cay-14010), PGF2alpha (Cay-16010, Cay-16020), PGD2...

Oleoyl ethanolamide (OEA) is an analog of the endocannabinoid AEA found in brain tissue and in chocolate. It is one of the long chain fatty acid ethanolamides that accumulates rapidly in infarcted tissue, but its biosynthesis is reduced in the intestine of rats following food deprivation. OEA is an endogenous,...

17-Octadecynoic Acid (17-ODYA) is a fatty acid alkyne. It is a suicide inhibitor of leukotriene B4 20-hydroxylase and renal CYP450 omega-hydroxylase. 17-ODYA (10 µM) completely inhibits the bradykinin-dependent transport of sodium chloride in rat TALH cells. It has been used as a click chemistry probe for labeling...

N-Oleoyl glycine is a putative substrate for peptidyl glycine alpha-amidating enzyme in the biosynthesis of oleoyl amide.Formal Name: N-[(9Z)-1-oxo-9-octadecen-1-yl]-glycine. CAS Number: 2601-90-3. Molecular Formula: C20H37NO3. Formula Weight: 339.5. Purity: >98%. Formulation: (Request formulation change), A...

Dihomo-gamma-linolenoyl ethanolamide is an endocannabinoid containing dihomo-gamma-linoleate in place of the arachidonate moiety of AEA. Dihomo-gamma-linolenoyl ethanolamide binds to recombinant human CB1 and CB2 receptors with Ki values of 857 and 598 nM, respectively. Its specific role and relative importance as a...

Dihomo-gamma-linolenic acid ethyl ester (ethyl DGLA) is an ester form of the omega-6 fatty acid intermediate DGLA (Cay-90230). Dietary administration of ethyl DGLA (1 g/kg per day for 25 days) increases prostaglandin E1 (PGE1, Cay-13010 ) and PGE2 (Cay-14010) secretion in rabbit renal papilla. Ethyl DGLA (1 g/kg per...