6 products were found matching "Cay90020-%25"!

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5,6-dehydro Arachidonic Acid
5,6-dehydro Arachidonic Acid

Item number: Cay90020-25

5,6-dehydro Arachidonic acid is an analog of arachidonic acid with an acetylene in the 5,6 position. It inhibits 5-LO in rat basophilic leukemia cells, with a Ki value of 15 µM. In guinea pig leukocytes, 5-LO is inhibited by 5,6-dehydro arachidonic acid with an IC50 value of 10 µM.Formal Name:...
Keywords: 5,6-dehydro AA, 8Z,11Z,14Z-eicosatrien-5-ynoic acid
Application: Bioactive lipid assays
CAS 58688-54-3
MW: 302.5 D
From 131.00€ *
Review
Seratrodast
Seratrodast

Item number: Cay9002014-25

Seratrodast is a potent antagonist of the thromboxane A2 (TXA2) receptor (TP), blocking specific binding of U-46619 (Cay-16450) to guinea pig platelets with an IC50 value of 7.4 nM and platelet aggregation induced by U-44069 (Cay-16440) with an IC50 value of 350 nM. It is metabolized, in liver microsomes, by...
Keywords: A-73001, AA2414, ABT-001, zeta-(2,4,5-trimethyl-3,6-dioxo-1,4-cyclohexadien-1-yl)-benzeneheptanoic acid
Application: Thromboxane A2 (TXA2) receptor antagonist
CAS 112665-43-7
MW: 354.4 D
From 60.00€ *
Review
WH-4-023
WH-4-023

Item number: Cay9002067-25

WH-4-023 is a selective inhibitor of the Src family of non-receptor tyrosine kinases (IC50s = 2 and 6 nM for Lck and Src, respectively). It inhibits the related kinases p38alpha and KDR at >300-fold higher concentrations (IC50s = 1.3 and 0.65 µM, respectively). At 1 µM, it has been used in combination with PD...
Keywords: N-(2,4-dimethoxyphenyl)-N-[2-[[4-(4-methyl-1-piperazinyl)phenyl]amino]-4-pyrimidinyl]-carbamic acid, 2,6-dimethylphenyl ester
Application: Lck / Src inhibitor
CAS 837422-57-8
MW: 568.7 D
From 53.00€ *
Review
EC 23
EC 23

Item number: Cay9002073-25

All-trans retinoic acid (ATRA, Cay-11017) is frequently used in cell culture to induce stem cell differentiation or enhance the growth, differentiation, and maintenance of neural cell types. Unfortunately, ATRA is readily susceptible to isomerisation and degradation upon exposure to light or other factors such as...
Keywords: AGN 190205, BASF 46928, 4-[2-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)ethynyl]-benzoic acid
Application: Photostable synthetic all-trans retinoic acid analog
CAS 104561-41-3
MW: 332.4 D
From 43.00€ *
Review
17(R)-Resolvin D3
17(R)-Resolvin D3

Item number: Cay9002880-25

17(R)-Resolvin D3 (17(R)-RvD3) is an aspirin-triggered epimer of resolvin D3 (Cay-13834). It is produced from docosahexaenoic acid (DHA, Cay-90310) by COX-2 in the presence of aspirin via a 17(R)-hydroperoxy DHA (17(R)-HDHA, Cay-10005099) intermediate and has been found in mouse inflammatory exudates. 17(R)-RvD3...
Keywords: 17(R)-RvD3, 17-epi-Resolvin D3, Aspirin-triggered Resolvin D3, AT-RvD3,...
Application: Aspirin-triggered resolvin D3 epimer
CAS 1427475-53-3
MW: 376.5 D
From 205.00€ *
Review
(+)-JQ1 (free acid)
(+)-JQ1 (free acid)

Item number: Cay9002910-25

(+)-JQ1 (free acid) is an inhibitor of bromodomain and extra terminal domain (BET) family proteins (Kds = 128, 59.5, 49.0, and 190 nM for JQ1 binding to bromodomains of BRD2, BRD3, BRD4, and BRDT, respectively), blocking their interaction with acetylated histones. Enantiomerically pure (+)-JQ1 (Cay-11187) binds to...
Keywords: (6S)-4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine-6-acetic acid
Application: BET family protein inhibitor
CAS 202592-23-2
MW: 400.9 D
From 73.00€ *
Review