14 products were found matching "Cay90020"!

5,6-dehydro Arachidonic acid is an analog of arachidonic acid with an acetylene in the 5,6 position. It inhibits 5-LO in rat basophilic leukemia cells, with a Ki value of 15 µM. In guinea pig leukocytes, 5-LO is inhibited by 5,6-dehydro arachidonic acid with an IC50 value of 10 µM.Formal Name:...

gamma-Linolenic acid (GLA) is an omega-6 fatty acid which can be elongated to arachidonic acid for endogenous eicosanoid synthesis. It is a weak LTB4 receptor antagonist, inhibiting [3H]-LTB4 binding to porcine neutrophil membranes with a Ki of 1 µM. GLA produces 53% inhibition at a 1 mg/kg dose in an in vivo model...

5,8,11-ETI is a nonselective inhibitor of lipoxygenases. It inhibits 12-LO in human platelets with an ID50 value of 24 µM. 5,8,11-ETI also inhibits A23187 and L-cysteine induced LTC4 biosynthesis in mouse mastocytoma cells with an ID50 value of 5 µM. At higher concentrations, 5,8,11-ETI also inhibits cyclooxygenases...

Branched-chain amino acid transferases (BCATs) catalyze reversible transamination of leucine, isoleucine, and valine branched-chain amino acids to their respective alpha-keto acids, liberating L-glutamate. Two forms of BCAT are present in mammals. Mitochondrial BCAT (BCATm) exists in most tissues throughout the...

Oleic acid alkyne is a form of oleic acid (Cay-90260) with an omega-terminal alkyne. The terminal alkyne group can be used in click chemistry linking reactions, to tag oleic acid with fluorescent or biotinylated labels for analysis of its metabolism and biological activity.Formal Name: (9Z)-9-octadecen-17-ynoic...

6-EAPB (hydrochloride) (Cay-9002053) is an analytical reference standard categorized as a benzofuran. This product is intended for research and forensic applications.Formal Name: N-ethyl-alpha-methyl-6-benzofuranethanamine, monohydrochloride. CAS Number: 1823318-37-1. Molecular Formula: C13H17NO . HCl. Formula...

DL-4662 is a 3,4-dimethoxy derivative of the substituted cathinones: pentedrone (Cay-11011) and alpha-pyrrolidinopentiophenone (Cay-9001083). It also features an ethylamine in place of the amino group that is typically attached to the alpha carbon of pentedrone. The physiological and toxicological properties of this...

Mebolazine is a synthetic derivative of testosterone (Cay-15645) that may bind to the androgen receptor and produce androgenic and anabolic activity. It has been used in a variety of clinical applications to address hypoandrogenic symptoms and to generate anabolic effects, however, it carries a potential for abuse....

Seratrodast is a potent antagonist of the thromboxane A2 (TXA2) receptor (TP), blocking specific binding of U-46619 (Cay-16450) to guinea pig platelets with an IC50 value of 7.4 nM and platelet aggregation induced by U-44069 (Cay-16440) with an IC50 value of 350 nM. It is metabolized, in liver microsomes, by...

WH-4-023 is a selective inhibitor of the Src family of non-receptor tyrosine kinases (IC50s = 2 and 6 nM for Lck and Src, respectively). It inhibits the related kinases p38alpha and KDR at >300-fold higher concentrations (IC50s = 1.3 and 0.65 µM, respectively). At 1 µM, it has been used in combination with PD...

All-trans retinoic acid (ATRA, Cay-11017) is frequently used in cell culture to induce stem cell differentiation or enhance the growth, differentiation, and maintenance of neural cell types. Unfortunately, ATRA is readily susceptible to isomerisation and degradation upon exposure to light or other factors such as...

Abz-Val-Ala-Asp-Nva-Arg-Asp-Arg-Gln-EDDnp is a fluorescence-quenched peptide substrate for human proteinase 3 (kcat/Km = 1,570 mM-1s-1). Enzymatic peptide hydrolysis disrupts the Abz:EDDnp donor-acceptor pair allowing fluorescence measurement of Abz (ex = 320 nm, em = 420 nm).Formal Name:...