- Search results for Cay81025-%25
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12 products were found matching "Cay81025-%25"!
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Item number: Cay81005-25
S-(2-aminoethyl) Isothiourea is a non-selective inhibitor of all NOS isoforms. For human nNOS, eNOS, and iNOS, the Ki values are 1.8, 2.1, and 0.59 µM, respectively.Formal Name: 2-aminoethyl carbamimidothioate, dihydrobromide. CAS Number: 56-10-0. Synonyms: Antiradon, NSC 22877. Molecular Formula: C3H9N3S . 2HBr....
Keywords: | Antiradon, NSC 22877, 2-aminoethyl carbamimidothioate, dihydrobromide |
Application: | NOS inhibitor |
CAS | 56-10-0 |
MW: | 281 D |
From 44.00€
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Item number: Cay81015-25
2-Imino-4-methylpiperidine is a potent, general NOS inhibitor. It exhibits IC50 values of 0.1, 1.1, and 0.2 µM for inhibition of human iNOS, eNOS, and nNOS, respectively, at an arginine concentration of 30 µM.Formal Name: 3,4,5,6-tetrahydro-4-methyl-2-pyridinamine, acetate. CAS Number: 165383-72-2. Molecular...
Keywords: | 3,4,5,6-tetrahydro-4-methyl-2-pyridinamine, acetate |
Application: | NOS inhibitor |
CAS | 165383-72-2 |
MW: | 171.2 D |
From 52.00€
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Item number: Cay81530-25
Aminoguanidine is equipotent to L-NMMA and L-NNA as an inhibitor of iNOS. The IC50 values for inhibition of mouse iNOS and rat nNOS are 5.4 and 160 µM, respectively. Aminoguanidine also inhibits induction of iNOS protein expression by endotoxin in rat macrophages.Formal Name: hydrazinecarboximidamide,...
Keywords: | Aminoguanidinium chloride, GER 11, Pimagedine, hydrazinecarboximidamide, monohydrochloride |
Application: | iNOS inhibitor |
CAS | 1937-19-5 |
MW: | 110.5 D |
From 34.00€
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Item number: Cay81280-25
EPIT is a selective, competitive inhibitor of nNOS having a Ki of 0.32 µM for the purified human enzyme. EPIT exhibits 115-fold and 29-fold selectivity for nNOS compared to iNOS and eNOS, respectively. It exhibits reduced inhibitory potency in whole-cell assays, possibly due to reduced intracellular uptake.Formal...
Keywords: | EPIT, ethyl[4-(trifluoromethyl)phenyl] carbamimidothioate, hydrochloride |
Application: | nNOS inhibitor |
CAS | 163490-78-6 |
MW: | 284.7 D |
From 43.00€
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Item number: Cay81500-25
1,3-PBIT is a potent inhibitor of iNOS with a Ki of 47 nM compared to Ki values for eNOS and nNOS are 9 and 0.25 µM, respectively, for the purified human enzymes. Its inhibition in whole cells is greatly diminished, presumably to poor membrane permeability.Formal Name:...
Keywords: | S,S'-1,3-phenylene-bis(1,2-ethanediyl)bis-isothiourea, dihydrobromide |
Application: | iNOS inhibitor |
CAS | 200716-66-1 |
MW: | 444.2 D |
From 26.00€
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Item number: Cay81260-25
2,4-Diamino-6-hydroxypyrimidine (DAHP) is a selective, specific inhibitor of GTP cyclohydrolase I, the rate limiting step for de novo pterin synthesis. In HUVEC cells, the IC50 for inhibition of BH4 biosynthesis is about 0.3 mM. DAHP can be used to effectively block NO production in several cell types.Formal Name:...
Keywords: | DAHP, 2,4-diamino-6(1H)-pyrimidinone |
Application: | GTP cyclohydrolase I inhibitor |
CAS | 56-06-4 |
MW: | 126.1 D |
From 35.00€
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Item number: Cay81600-25
NS 2028 is a specific inhibitor of soluble guanylyl cyclase. It inhibits purified bovine lung guanylyl cyclase in a concentration dependent and irreversible manner with IC50 values of 30 and 200 nM for basal and NO-stimulated enzymes, respectively. S-nitroso-glutathione-enhanced guanylyl cyclase activity in mouse...
Keywords: | 8-bromo-4H-2,5-dioxa-3,9b-diaza-cyclopenta[a]naphthalen-1-one |
Application: | Guanylyl cyclase inhibitor |
CAS | 204326-43-2 |
MW: | 269.1 D |
From 64.00€
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Item number: Cay82110-25
DPTA NONOate is a NO donor. It spontaneously dissociates in a pH-dependent, first-order process with a half-life of three hours and five hours at 37°C and 22-25°C, pH 7.4, respectively, to liberate 2 moles of NO per mole of parent compound.Formal Name:...
Keywords: | Dipropylenetriamine NONOate, (Z)-1-[N-(3-aminopropyl)-N-(3-ammoniopropyl)amino]diazen-1-ium-1,2-diolate |
Application: | NO donor |
CAS | 146724-95-0 |
MW: | 191.2 D |
From 53.00€
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Item number: Cay20810-25
M50054 is a cell-permeable inhibitor of the activation of caspase-3, blocking characteristic features of apoptosis, including DNA fragmentation and externalization of phosphatidylserine. It blocks apoptosis in a variety of cell lines induced by different stimuli, including Fas ligand and etoposide (Cay-12092)....
Keywords: | 2,2'-methylenebis-1,3-cyclohexanedione |
Application: | Cell-permeable caspase-3 activation inhibitor, Apoptosis blocker |
CAS | 54135-60-3 |
MW: | 236.3 D |
From 43.00€
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Item number: Cay21810-25
AAT-008 is an orally bioavailable and potent antagonist of the prostaglandin E2 (PGE2) receptor subtype 4 (EP4, IC50 = 16.3 nM in a human EP4 functional assay). It is selective for EP4 with IC50 values of 2.4, 1,890, >20,000, and >20,000 nM for binding to human recombinant EP4, EP2, EP1, and EP3, respectively....
Keywords: | 4-[(1S)-1-[[[5-chloro-2-(3-fluorophenoxy)-3-pyridinyl]carbonyl]amino]ethyl]-benzoic acid |
Application: | EP4 antagonist |
CAS | 847727-81-5 |
MW: | 414.8 D |
From 43.00€
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Item number: Cay26810-25
4-Methylumbelliferyl-alpha-D-glucopyranoside is a fluorogenic substrate for alpha-glucosidase. 4-Methylumbelliferyl-alpha-D-glucopyranoside is cleaved by alpha-glucosidase to release the fluorescent moiety 4-methylumbelliferyl (4-MU). 4-MU fluorescence is pH-dependent with excitation maxima of 320 and 360 nm at low...
Keywords: | 4-Methylumbelliferyl-alpha-D-Glucose, 4-Methylumbelliferyl-alpha-D-Glucoside, 4-MU-alpha-D-Glucopyranoside,... |
Application: | Fluorogenic alpha-glucosidase substrate |
CAS | 17833-43-1 |
MW: | 338.3 D |
From 60.00€
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Item number: Cay27810-25
Betulinic aldehyde is a triterpenoid that has been found in Z. cambodiana and has diverse biological activities. It is active against P. falciparum (IC50 = 6.5 µg/ml) and M. tuberculosis (MIC = 25 µg/ml) in vitro, as well as laboratory and clinical isolates of methicillin-resistant and -sensitive S. aureus (MICs =...
Keywords: | Betulinaldehyde, NSC 250423, 3beta-hydroxy-lup-20(29)-en-28-al |
Application: | Bioactive triterpenoid |
CAS | 13159-28-9 |
MW: | 440.7 D |
From 163.00€
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