10 products were found matching "Cay71435-%25"!

Nigericin is a lipophilic potassium ionophore that has been found in S. hygroscopicus. It mediates neutral antiport of potassium and proton ions across mitochondrial membranes. Nigericin (10 µM) induces T. gondii egress in infected human foreskin fibroblasts (HFFs). It also induces NOD-like receptor protein 3...

Tetramethylrhodamine methyl ester (TMRM) (perchlorate) is a non-cytotoxic cell-permeant fluorogenic dye most commonly used to assess mitochondrial function using live cell fluorescence microscopy and flow cytometry. It has two excitation peaks at 515 and 555 nm and an emission peak in the red-orange range (575 nm)....

GSK2018682 is an agonist of sphingosine-1-phosphate receptor 1 (S1P1) and S1P5. It is selective for S1P1 and S1P5 over S1P2, S1P3, and S1P4 receptors. GSK2018682 is efficacious in a mouse model of experimental autoimmune encephalomyelitis (EAE).Formal Name:...

(Arg)9 is a cationic cell-penetrating peptide. It has been used to deliver various cargo to cells, including fluorescent proteins and plasmids. (Arg)9 (5 and 10 µM) also protects primary rat cortical neurons from glutamate-induced excitotoxicity.Formal Name:...

ENPP1-IN-1 is an inhibitor of ectonucleotide pyrophosphatase/phosphodiesterase 1 (ENPP1). It inhibits the hydrolysis of 2'3'-cGAMP (Cay-19887) and the ATP analog p-nitrophenyl 5'-adenosine monophosphate (AMP-pNP, Kis = =100 and 100-1,000 nM, respectively, in enzyme assays). ENPP1-IN-1 enhances transcription of the...

Guanosine 5'-diphosphate (GDP) is a purine nucleotide and biosynthetic precursor of guanosine 5'-triphosphate (GTP, Cay-16060). It has been used to study the conformations of GTPases. GDP (100 µM) activates sulfonylurea receptor 2B (SUR2B) linked to the inward-rectifier potassium channel 6.1 (Kir6.1) in HEK293T...

WP1066 is a cell-permeable inhibitor of STAT3 that directs dephosphorylation and nuclear export of constitutively phosphorylated STAT3 in U87-MG and U373-MG malignant glioma cells when given at a concentration of 10 µM. It also induces apoptosis in U87-MG (IC50 = 5.6 µM) and U373-MG (IC50 = 3.7 µM) cells. WP1066 is...

Cimbuterol is an agonist of beta-adrenergic receptors (beta-ARs). It has been used as a standard for the simultaneous detection of multiple veterinary residues in commercial animal meat by LC-MS/MS. Cimbuterol has been used illicitly to promote growth and improve feed efficiency in livestock.Formal Name:...

DC4 crosslinker is a mass spectrometry-cleavable crosslinking reagent (18Å in length) that contains two intrinsic positive charges, which allow cross-linked peptides to fragment into their component peptides by collision-induced dissociation or in-source decay. Initial fragmentation events result in cleavage on...

Salubrinal is a selective phosphatase inhibitor that prevents dephosphorylation of eukaryotic translation initiation factor 2 subunit alpha (eIF2alpha), protecting PC12 cells from endoplasmic reticulum stress-mediated apoptosis (EC50 = 15 µM). It appears to block the action of protein phosphatase 1 (PP1) on...