Uridine is a pyrimidine nucleoside composed of uracil (Cay-26088) and ribose. It forms complementary base pairs with adenosine (Cay-21232) in RNA. Uridine can be catabolized to uracil via uridine phosphorylase, and it can be phosphorylated to UMP (Cay-35382) by uridine-cytidine kinase (UCK). It is replaced with...

LC10 is a lipidoid derivative of the secondary bile acid lithocholic acid (Cay-20253) that contains two 10-carbon alkyl chains. It has been used in the generation of self-assembling skin-permeable lipid nanoparticles (LNPs). LC10 LNPs inhibit the proliferation of normal human epidermal keratinocytes (NHEKs) when...

Guaiacol is a phenolic natural product first isolated from Guaiac resin and the oxidation of lignin. Guaiacol is readily oxidized by the heme iron of peroxidases including the peroxidase of cyclooxygenase (COX) enzymes. It therefore serves as a reducing co-substrate for COX reactions. The color yield per peroxide at...

Adrenic acid is a naturally occurring polyunsaturated fatty acid (PUFA) formed through a 2-carbon chain elongation of arachidonic acid. It is present in the adrenal glands, brain, testis, and kidney. Although there is trace metabolism of adrenic acid in the forebrain, the renal medulla is the only tissue which...