12 products were found matching "Cay60900"!

PAF C-16 is a naturally occurring phospholipid produced upon stimulation through two distinct pathways known as the "remodeling" and 'de novo' pathways. It is a potent mediator of neutrophil migration, and the production of reactive oxygen species, and IL-6 in human macrophages. It is a more potent mediator of...

Mammalian soluble epoxide hydrolase (sEH) is a member of the alpha/beta-hydrolase fold family of enzymes that catalyze the hydrolysis of exogenous and endogenous epoxides to vicinal diols. sEH is a homodimer consisting of two domains. The C-terminal domain is responsible for the epoxide hydrolase activity while the...

Apoptosis is associated with the fragmentation of chromosomal DNA into multiples of the 180 bp nucleosomal unit, known as DNA laddering. This kit is designed to maximize extraction of small fragments of DNA with minimal contamination from intact chromatin. The isolated DNA is separated by electrophoresis and can be...

Lyso-PAF C-16 can be formed by either the action of PAF-AH on PAF C-16, or by the action of a CoA-independent transacylase on 1-O-hexadecyl-2-acyl-glycerophosphocholine. Lyso-PAF C-16 is a substrate for either PAF C-16 formation by the remodeling pathway or selective acylation with arachidonic acid by a...

Methylcarbamyl PAF C-16 is a stable analog of PAF C-16 with a half-life greater than 100 minutes in platelet poor plasma due to its resistance to degradation by PAF-AH. It is nearly equipotent with PAF C-16 in its ability to induce platelet aggregation both in isolated platelets and in platelet-rich plasma. In...

1-O-hexadecyl-2-Dihomo-gamma-linolenoyl-sn-glycero-3-PC is a PAF analog which contains dihomo-gamma-linolenoate at the sn-2 position rather than the acetate moiety found in PAF C-16. The biological activities of 1-O-hexadecyl-2-dihomo-gamma-linolenoyl-sn-glycero-3-PC are not known at present, but may be similar to...

2-O-methyl PAF C-16 is a synthetic PAF analog which contains a methyl group, attached by an ether linkage, at the sn-2 position. Although the biological activities of 2-O-methyl PAF C-16 have not been well characterized, the C-18 analog has been shown to mediate a number of biological responses including decreasing...

1-O-hexadecyl-2-Docosahexaenoyl-sn-glycero-3-PC is a PAF analog which contains docosahexaenoate at the sn-2 position rather than the acetate moiety found in PAF C-16. 1-O-hexadecyl-2-Docosahexaenoyl-sn-glycero-3-PC can be oxidatively fragmented resulting in the production of phospholipids with PAF-like...

1-O-hexadecyl-2-Eicosapentaenoyl-sn-glycero-3-PC can be formed by incorporation of eicosapentaenoic acid (EPA) into lyso-PAF C-16, as has been demonstrated using neutrophils from monkeys and humans fed a diet enriched in fish oils. 1-O-hexadecyl-2-Eicosapentaenoyl-sn-glycero-3-PC can serve as a substrate for PAF...

1-O-hexadecyl-2-Arachidonoyl-sn-glycero-3-PC is the product of acylation of lyso-PAF C-16 (Cay-60906) by a CoA-independent transacylase. It is the most common precursor for formation of PAF C-16 (Cay-60900) by the remodeling pathway.Formal Name:...

Hexanolamino PAF C-16 is a PAF analog with mixed agonist/antagonist properties. In human monocyte-derived macrophages, it is an antagonist which inhibits the production of reactive oxygen species in response to PAF C-16. On the other hand, in rabbit platelets and guinea pig macrophages, hexanolamino PAF C-16 is a...

Pyrrolidino PAF C-16 is a synthetic analog of PAF C-16. It is a potent mediator of PAF-like activities, including hypotension and platelet aggregation, where it is approximately 3-10 times more potent than PAF itself.Formal Name: 1-O-hexadecyl-2-O-acetyl-sn-glyceryl-3-phosphoryl-N-methyl-pyrrolidinium ethanol. CAS...