11 products were found matching "Cay60122-%25"!

1-Oleoyl-2-palmitoyl-sn-glycero-3-PC (1,2-OPPC) is a phospholipid containing oleic acid (Cay-90260) and palmitic acid (Cay-10006627) at the sn-1 and sn-2 positions, respectively, that is found in biological membranes. It can be used in the generation of liposomes and other artificial membranes. Artificial membranes...

3-hydroxy-4-Methoxyphenethylamine is a metabolite of the catecholamine dopamine (Cay-36532, Cay-21992). It is formed from dopamine by catechol-O-methyltransferase (COMT). 3-hydroxy-4-Methoxyphenethylamine (200 µM) decreases the viability of SH-SY5Y cells. It induces tachycardia and increases blood pressure in...

Phensuximide is an anticonvulsant. It inhibits seizures induced by maximal electroshock (MES) and pentylenetetrazole (Cay-18682) in mice (ED50s = 112 and 50 mg/kg, respectively). Phensuximide (1.25 mmol/kg, i.p.) induces proteinuria and hematuria in rats. Formulations containing phensuximide have been used in the...

(R)-Ofloxacin is a fluoroquinolone antibiotic and the (R) isomer of the antibiotics ofloxacin (Cay-22891) and levofloxacin (Cay-20382). It is active against certain Gram-positive and Gram-negative bacteria, including E. coli, P. aeruginosa strains 32104 and 32122, S. aureus strains 209P and Smith, and S. epidermis...

R-(-)-alpha-Methylhistamine is a histamine H3 receptor agonist with diverse biological activities. It inhibits the release of histamine induced by antidromic electrical stimulation of the sciatic nerve in rats when administered at doses ranging from 0.25 to 2 mg/kg, an effect that can be reversed by the selective...

Many of the products generated by alkylating agents on DNA can be efficiently repaired by normal base excision repair (BER). Some poly(ADP-ribose) polymerases (PARPs) assist in the repair of single-strand DNA nicks, an important step in BER. Olaparib is a potent inhibitor of PARP1 and PARP2 (IC50 = 5 and 1 nM,...

Benzamidine is a reversible inhibitor of serine proteases, including trypsin, plasmin, and thrombin (Kis = 35, 350, and 220 µM, respectively). In addition to its use as a general serine protease inhibitor, benzamidine is used, when immobilized, to purify novel proteases.Formal Name: benzenecarboximidamide,...

HPPH is a chlorin that acts as a photosensitizer in photodynamic therapy (PDT) when stimulated with light at 655 nm. When administered systemically, HPPH accumulates in tumor cells and, when stimulated with light in the presence of oxygen, reactive oxygen species (ROS) are generated, leading to necrosis within the...

Pyrroloquinoline quinone (PQQ) is a quinone and redox enzyme cofactor that has been found in a variety of bacteria and has diverse biological activities. It inhibits fibril formation by the amyloid proteins amyloid-beta (1-42) (Abeta42) and mouse prion protein when used at a concentrations of 100 and 300 µM. PQQ...

Polygalaxanthone III is a xanthone glycoside that has been found in P. hongkongensis and has antioxidant activity. It scavenges hydroxyl and 2,2-diphenyl-1-picrylhydrazyl (DPPH, Cay-14805) radicals in cell-free assays (IC50s = 83.5 and 76.1 µM, respectively).Formal Name:...

Cyclooxygenase 2 (COX-2) is a bifunctional enzyme that exhibits both COX and peroxidase activities and catalyzes the first step in the biosynthesis of prostaglandins, thromboxanes, and prostacyclins. The COX component converts arachidonic acid to the hydroperoxy endoperoxide prostaglandin G2 (PGG2, Cay-17010), and...