7 products were found matching "Cay534721-%25"!
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NVP-2
Item number: Cay34725-25
NVP-2 is an inhibitor of the Cdk9/cyclin T1 complex (IC50 = 50s = 0.584->10 µM), as well as over a panel of 468 kinases at 1 µM. NVP-2 (250 nM) inhibits the proliferation of, and induces apoptosis in, MOLT-4 human acute lymphoblastic leukemia cells.Formal Name:...
| Keywords: | 4-[[[5'-chloro-2'-[[trans-4-[[(1R)-2-methoxy-1-methylethyl]amino]cyclohexyl]amino][2,4'-bipyridin]-6-yl]amino]methyl]tetra... |
| Application: | Cdk9/cyclin T1 complex inhibitor |
| CAS | 1263373-43-8 |
| MW: | 513.1 D |
From 60.00€
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NS 11021
Item number: Cay15347-25
NS 11021 is an activator of large-conductance Ca2+-activated potassium channels (BKCa/KCa1.1). It is selective for BKCa and is thought to bind directly the alpha subunit. NS 11021 has been shown to relax intracavernous arterial rings and corpus cavernosum strips in vitro and to enhance erectile responses in intact...
| Keywords: | N'-[3,5-bis(trifluoromethyl)phenyl]-N-[4-bromo-2-(2H-tetrazol-5-yl)phenyl]-thiourea |
| Application: | KCNMA1 activator |
| CAS | 956014-19-0 |
| MW: | 511.2 D |
From 43.00€
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N-Methylcytisine
Item number: Cay34752-25
N-Methylcytisine is an alkaloid that has been found in L. albus and has diverse biological activities. It is an agonist of nicotinic acetylcholine receptors (nAChRs) and selectively binds to nAChRs over muscarinic acetylcholine receptors (mAChRs, IC50s = 0.05 and 417 µM, respectively). It elicits whole-cell currents...
| Keywords: | Caulophylline, N-Me-cy, (1R,5S)-1,2,3,4,5,6-hexahydro-3-methyl-1,5-methano-8H-pyrido[1,2-a][1,5]diazocin-8-one |
| Application: | Bioactive alkaloid |
| CAS | 486-86-2 |
| MW: | 204.3 D |
From 98.00€
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Allocryptopine
Item number: Cay34751-25
Allocryptopine is an isoquinoline alkaloid that has been found in M. cordata and has antimicrobial activity. It is active against S. aureus, P. aeruginosa, and E. coli (MICs = 250, 125, and 125 µg/ml, respectively), the protozoa P. falciparum and E. histolytica (IC50s = 5.08 and 135 µM, respectively), as well as a...
| Keywords: | alpha-Allocryptopine, alpha-Fagarine, beta-Homochelidonine,... |
| Application: | Isoquinoline alkaloid, Antimicrobial agent |
| CAS | 485-91-6 |
| MW: | 369.4 D |
From 34.00€
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Gisadenafil (besylate)
Item number: Cay31472-25
Gisadenafil is a phosphodiesterase 5 (PDE5) inhibitor (IC50 = 1.1 nM). It is 103-fold selective for PDE5 over PDE6 at 1.1 nM. Gisadenafil (2 mg/kg) restores the wild-type response to hypercapnia, increased cortical blood flow and dilation of small arteriols, in the GFAP-driven, doxycycline-inducible HIV-1 Tat...
| Keywords: | UK 369003,... |
| Application: | PDE5 inhibitor |
| CAS | 334827-98-4 |
| MW: | 677.8 D |
From 43.00€
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7-Benzyloxy-4-(trifluoromethyl)coumarin
Item number: Cay35721-25
7-Benzyloxy-4-(trifluoromethyl)coumarin (BFC) is a fluorogenic substrate for the cytochrome P450 (CYP) isoforms CYP1A2 and CYP3A. Upon enzymatic cleavage by CYP1A2 or CYP3A, 7-hydroxy-4-(trifluoromethyl)coumarin (HFC) is released and its fluorescence can be used to quantify CYP1A2 and CYP3A activity. HFC displays...
| Keywords: | BFC, 7-(phenylmethoxy)-4-(trifluoromethyl)-2H-1-benzopyran-2-one |
| Application: | Fluorogenic CYP1A2 / CYP3A substrate |
| CAS | 220001-53-6 |
| MW: | 320.3 D |
From 100.00€
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Byakangelicol
Item number: Cay34571-25
Byakangelicol is a furanocoumarin that has been found in A. dahurica and has diverse biological activities. It inhibits acetylcholinesterase (AChE) and butyrylcholinesterase (BChE, IC50s = 46.3 and 45.2 µM, respectively). Byakangelicol inhibits LPS-induced production of nitric oxide (NO) in RAW 264.7 cells (IC50 =...
| Keywords: | 9-[[(2R)-3,3-dimethyl-2-oxiranyl]methoxy]-4-methoxy-7H-furo[3,2-g][1]benzopyran-7-one |
| Application: | Bioactive furanocoumarin |
| CAS | 26091-79-2 |
| MW: | 316.3 D |
From 60.00€
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