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AM6545
AM6545

Item number: Cay16316-25

Peripherally-restricted cannabinoid receptor 1 (CB1) selective antagonists have the potential to inhibit food intake while also escaping centrally-mediated neuropsychiatric side effects. AM6545 is a novel CB1 selective neutral antagonist with low CNS penetration, exhibiting Ki values of 1.7 and 523 nM for CB1 and...
Keywords: 5-[4-(4-cyano-1-butyn-1-yl)phenyl]-1-(2,4-dichlorophenyl)-N-(1,1-dioxido-4-thiomorpholinyl)-4-methyl-1H-pyrazole-3-carboxa...
Application: CB1 selective neutral antagonist
CAS 1245626-05-4
MW: 556.5 D
From 60.00€ *
Review
Sotalol (hydrochloride)
Sotalol (hydrochloride)

Item number: Cay16136-25

Sotalol is a non-selective antagonist of beta-adrenergic receptors (beta-ARs, IC50s = 8.9 and 5.2 µM for beta1- and beta2-ARs, respectively) and a class III antiarrhythmic agent. It decreases delayed outward potassium currents (IK) in guinea pig ventricular cells and prolongs action potential duration in...
Keywords: (±)-Sotalol, DL-Sotalol, MJ1999, N-[4-[1-hydroxy-2-[(1-methylethyl)amino]ethyl]phenyl]-methanesulfonamide, monohydrochloride
Application: beta1/2-adrenergic receptor antagonist
CAS 959-24-0
MW: 308.8 D
From 43.00€ *
Review