17 products were found matching "Cay500501"!

The primary synthesis of functional vitamin D begins in the skin, where a cholesterol by-product acted upon by UV light forms vitamin D3. Vitamin D3 is carried through the bloodstream, attached to the vitamin D binding protein, to the liver where it is converted to 25-hydroxy vitamin D3 (25(OH)D3). This product is...

Bazedoxifene (acetate) is a third generation selective estrogen receptor modulator (SERM). It is an indole-based ER ligand that binds to both ERalpha (IC50 = 26 nM) and ERbeta (IC50 = 99 nM). Bazedoxifene (actetate) antagonizes 17beta-estradiol-dependent MCF-7 and T47D breast cancer cell proliferation in vitro as...

4F 4PP is an antagonist of the serotonin (5-HT) receptor subtype 5-HT2A (Ki = 5.3 nM). It is selective for 5-HT2A receptors over 5-HT1C receptors (Ki = 620 nM). It inhibits 5-HT-induced currents in Xenopus oocytes expressing human 5-HT2A receptors (IC50 = 5.15 µM). Spinal superfusion of 4F 4PP (100 µM) reduces the...

(±)11(12)-EET (Cay-50511) is biosynthesized in rat and rabbit liver microsomes by CYP450. (±)11(12)-EET has been shown, along with (±)8(9)-EET (Cay-50351), to play a role in the recovery of depleted Ca2+ pools in cultured smooth muscle cells. (±)11(12)-EET methyl ester is a more stable for used for long-term...

Prostaglandin J2 (PGJ2) is a metabolite of PGD2 (Cay-12010) and an agonist of the prostaglandin D2 (PGD2) receptor subtypes DP1 and DP2/CRTH. It is formed from PGD2 by spontaneous dehydration. PGJ2 binds to DP1 and DP2/CRTH receptors (Kis = 0.9 and 6.6 nM, respectively) and either increases or inhibits the...

Cayman's Creatinine (urinary) Colorimetric Assay Kit can be used to measure creatinine levels in urine. The assay relies on the Jaffe reaction, wherein a yellow/orange color forms when the metabolite is treated with alkaline picrate. The color derived from creatinine is then destroyed at acidic pH. The difference in...

Cercosporamide is a natural antifungal phytotoxin isolated from the Cercosporidium fungus, which infects the leaves of cassava plants. Its antifungal effect results from its selective and potent inhibition of fungal PKC-like 1 kinases (Pkc1), which are central to cell wall integrity (IC50 = 25 nM for Candida Pkc1)....

(±)8(9)-EET methyl ester is an esterified version of (±)8(9)-EET (Cay-50351) that is more stable for long-term storage and can be readily hydrolyzed to the free acid just before use.Formal Name: (±)8,9-epoxy-5Z,11Z,14Z-eicosatrienoic acid, methyl ester. Synonyms: (±)8,9-EpETrE methyl ester. Molecular Formula:...

(±)14(15)-EET methyl ester is an esterified version of (±)14(15)-EET (Cay-50651) that is more stable for long-term storage and can be readily hydrolyzed to the free acid just before use. It is equipotent to (±)14(15)-EET in inducing relaxation of isolated bovine coronary arteries precontracted by the thromboxane...

(±)12(13)-EpOME is the 12,13-cis epoxide form of linoleic acid (Cay-90150, Cay-90150.1, Cay-21909). It is formed primarily via linoleic acid metabolism by the cytochrome P450 (CYP) isoforms CYP2J2, CYP2C8, and CYP2C9, however, CYP1A1 can contribute to (±)12(13)-EpOME production when pharmacologically induced....

4-biphenylthio Carboxamide is a synthetic intermediate useful for pharmaceutical synthesis.Formal Name: [1,1'-biphenyl]-4-carbothioamide. CAS Number: 13363-50-3. Synonyms: Biphenyl-4-Carbothioic Acid amide. Molecular Formula: C13H11NS. Formula Weight: 213.3. Purity: >98%. Formulation: (Request formulation change), A...

Cayman's Lipid Droplets Fluorescence Assay Kit can be used to study regulators of lipid droplet biogenesis. The main advantage of this assay is that the green fluorescence of Nile Red is both very sensitive and specific for lipid droplets. Furthermore, changes in lipid droplet biogenesis in various cell types in...