12 products were found matching "Cay38410"!

9(S)-HODE is a metabolite of the omega-6 polyunsaturated fatty acid linoleic acid (Cay-90150, Cay-90150.1, Cay-21909). It is formed from linoleic acid by lipoxygenases. 9(S)-HODE (68 µM) increases transactivation of peroxisome proliferator-activated receptor alpha (PPARalpha) and PPARgamma in reporter assays using...

Beclomethasone 17-propionate is a glucocorticoid receptor agonist and an active metabolite of the glucocorticoid prodrug beclomethasone dipropionate (Cay-38880). It is formed from beclomethasone dipropionate via esterases and is subsequently hydrolyzed to beclomethasone (Cay-33196). Beclomethasone 17-propionate...

9(S)-HODE-d4 is intended for use as an internal standard for the quantification of 9-HODE by GC- or LC-MS. (±)-9-HODE is formed via non-enzymatic oxidation of linoleic acid (Cay-90150, Cay-90150.1, Cay-21909). 9(S)-HODE and 9(R)-HODE are formed by lipoxygenase- and cyclooxygenase-mediated oxidation of linoleic acid,...

Ingliforib is an inhibitor of the liver, muscle, and brain forms of glycogen phosphorylase (IC50s = 52, 352, and 150 nM, respectively). It decreases myocardial glycogen phosphorylase activity and infarct size as a percentage of the area at risk in a rabbit model of ischemia-reperfusion injury induced by coronary...

PF-249 is an allosteric activator of AMP-activated protein kinase beta1 (AMPKbeta1) heterotrimers (EC50s = 8 and 6 nM for human AMPK alpha1beta1gamma1 and -alpha2beta1gamma1, respectively). It is selective for AMPK alpha1beta1gamma1 and -alpha2beta1gamma1 over AMPK alpha1beta2gamma1, -alpha2beta2gamma1, and...

GPX4 24 is an inhibitor of glutathione peroxidase 4 (GPX4) and a derivative of (1S,3R)-RSL3 (Cay-19288). It covalently binds to GPX4 in 4T1 murine mammary carcinoma cells in a concentration-dependent manner. GPX4 24 induces ferroptosis in GPX4-dependent HT-1080 fibrosarcoma cells (EC50 = 0.16 µM). It increases...

2-Amino-3-[2-(tert-butoxy)-2-oxoethoxy]propanoic acid is a derivative of the amino acid serine.Formal Name: O-(2-(tert-butoxy)-2-oxoethyl)serine. Molecular Formula: C9H17NO5. Formula Weight: 219.2. Purity: >95%. Formulation: (Request formulation change), A solid. Solubility: PBS (pH 7.2): 5 mg/ml. SMILES:...

LAU-0901 is a platelet-activating factor (PAF) receptor antagonist., In vivo, LAU-0901 (30, 60, and 90 mg/kg) reduces infarct volume and improves neurological function in a rat model of cerebral ischemia induced by middle cerebral artery occlusion (MCAO). It also reduces microglial infiltration and increases...

1-Palmitoyl-2-pyropheophorbide a-sn-glycero-3-PC is a phospholipid-porphyrin conjugate that is composed of phosphatidylcholine containing palmitic acid (Cay-10006627) at the sn-1 position and the photosensitizer pyropheophorbide a (Cay-21371) at the sn-2 position. Lipid nanoparticles (LNPs) containing...

1,2-bis(heptanoylthio)-sn-glycero-3-PG is a sulfur-containing phosphoglycerol.Formal Name: S,S'-((2S)-3-(((2,3-dihydroxypropoxy)(hydroxy)phosphoryl)oxy)propane-1,2-diyl) diheptanethioate, monosodium salt. Synonyms: 1,2-bis(heptanoylthio) Glycerophosphatidylglycerol, 1,2-bis(heptanoylthio) Glycerophosphoglycerol,...

9(S)-HODE cholesteryl ester was originally extracted from atherosclerotic lesions. It remains uncertain whether the oxidized fatty acid portion of the molecule results from enzymatic lipoxygenation or from random lipid peroxidation. 9(S)-HODE cholesteryl ester can be used as a standard for analysis of chiral HODE...

ONO-8711 is an antagonist of the prostaglandin E2 (PGE2, Cay-14010) receptor subtype EP1 (Kis = 0.6 and 1.7 nM for human and mouse receptors, respectively, expressed in CHO cells). It is selective for EP1 over EP2, EP3, and EP4 (Kis = >1,000, 67, and >1,000 nM, respectively, for mouse receptors expressed in CHO...