8 products were found matching "Cay338410"!

9(S)-HODE-d4 is intended for use as an internal standard for the quantification of 9-HODE by GC- or LC-MS. (±)-9-HODE is formed via non-enzymatic oxidation of linoleic acid (Cay-90150, Cay-90150.1, Cay-21909). 9(S)-HODE and 9(R)-HODE are formed by lipoxygenase- and cyclooxygenase-mediated oxidation of linoleic acid,...

Beclomethasone 17-propionate is a glucocorticoid receptor agonist and an active metabolite of the glucocorticoid prodrug beclomethasone dipropionate (Cay-38880). It is formed from beclomethasone dipropionate via esterases and is subsequently hydrolyzed to beclomethasone (Cay-33196). Beclomethasone 17-propionate...

9(S)-HODE is a metabolite of the omega-6 polyunsaturated fatty acid linoleic acid (Cay-90150, Cay-90150.1, Cay-21909). It is formed from linoleic acid by lipoxygenases. 9(S)-HODE (68 µM) increases transactivation of peroxisome proliferator-activated receptor alpha (PPARalpha) and PPARgamma in reporter assays using...

(+)-Oxypeucedanin hydrate is a furanocoumarin that has been found in A. japonica and has diverse biological activities. It is active against the Gram-positive bacteria B. cereus, S. aureus, and S. faecalis (MICs = 9.76-78.12 µg/ml), the Gram-negative bacteria E. coli, S. dysenteriae, P. aeruginosa, K. pneumoniae,...

HT-2157 is an antagonist of the galanin-3 receptor (GAL3, Ki = 17 nM). It is selective for GAL3 over GAL1 and GAL2 (Kis = >10 µM for both). HT-2157 (10 µM) induces apoptosis in various cell types, including HL-60 leukemia and BV-2 murine microglial cells, as well as isolated human peripheral blood mononuclear cells...

1,4-Dicaffeoylquinic acid is a polyphenol that has been found in C. coronarium and has diverse biological activities. It scavenges DPPH (Cay-14805) radicals and inhibits xanthine oxidase (XO, IC50 = 7.36 µM). 1,4-Dicaffeoylquinic acid (25 µM) decreases protein levels of tyrosinase and microphthalmia-associated...

t-TUCB is a soluble epoxide hydrolase (sEH) inhibitor (IC50s = 0.4, 3.1, and 11.9 nM for the human, mouse, and rat enzymes, respectively). It also inhibits fatty acid amide hydrolase (FAAH, IC50 = 260 nM for the human enzyme). t-TUCB (3 mg/kg) increases the mechanical paw withdrawal threshold in a mouse model of...

T-705 is an antiviral agent that inhibits influenza A, B, and C (IC50s = 0.013-0.48 µg/ml) without inducing cytotoxicity up to 1,000 µg/ml. It inhibits a neuraminidase-resistant influenza strain (GS4071-resistant, IC50 = 0.095 µg/ml) and RNA viruses (IC50s = 4.8-41 µg/ml) but not DNA viruses at concentrations...