8 products were found matching "Cay316767-%25"!

Myelin basic protein (MBP) peptide is a peptide substrate for PKC. It is selective for PKC over PKA, casein kinase 1 (CK1), CK2, phosphorylase kinase, and calcium/calmodulin-dependent protein kinase (CaMKII). MBP peptide has been used to monitor PKC activity in primary human renal artery smooth muscle cells.Formal...

Tetrahydroepiberberine is an alkaloid originally isolated from P. rhoeas that has diverse biological activities. It is active against the fungus C. albicans (MIC = 8 µg/ml), as well as the bacteria E. coli, P. aeruginosa, P. mirabilis, K. pneumoniae, A. baumannii, S. aureus, and B. subtilis (MICs = 32-64 µg/ml,...

Lipid A9 is an ionizable cationic lipid (pKa = 6.27). It has been used in combination with other lipids in the formation of lipid nanoparticles (LNPs) for the delivery of mRNA.Formal Name: bis(2-butyloctyl) 10-(N-(3-(dimethylamino)propyl)nonanamido)nonadecanedioate. CAS Number: 2036272-50-9. Molecular Formula:...

Samatasvir is an inhibitor of hepatitis C virus (HCV) non-structural protein 5A (NS5A). It inhibits HCV replication in stable replicon cell lines containing NS5A from genotypes 1a, -1b, -2a, -3a, -4a, and -5a (EC50s = 2-24 pM). Samatasvir acts additively with the nucleotide prodrug IDX184, NS5B inhibitor TMC647055,...

VK-II-86 is an inhibitor of store-overload-induced calcium release (SOICR) and a derivative of carvedilol (Cay-15418). It inhibits SOICR in HEK293 cells expressing the ryanodine receptor 2 (RyR2) R4496C (RyR2R4496C) mutation (IC50 = 16.8 µM), a mutation that results in spontaneous calcium release from the...

The amino acid gamma-aminobutyric acid (GABA) is an inhibitory neurotransmitter that acts through two families of heteromeric ligand-gated ion channels, GABAA and GABAC and a G protein-coupled receptor, GABAB. Muscimol is a full GABAA agonist and partial GABAC agonist. It binds GABAA on both high- and low-affinity...

WS3 is a non-specific proliferative molecule that modulates the activity of Erb3 binding protein-1 and the IkappaB kinase pathway. It has been used to mediate proliferation of primary retinal pigment epithelial cells ex vivo in order to provide a renewable source of cells for transplantation in a model of retinal...

Fluzoparib is an inhibitor of poly(ADP-ribose) polymerase 1 (PARP1, IC50 = 1.46 nM). It induces DNA double-strand breaks in wild-type, but not BRCA2-/-, V-C8 cells, as well as BRCA1-/- MDA-MB-436 cells when used at concentrations of 1 and 10 µM. Fluzoparib inhibits the proliferation of BRCA2-/- V-C8 cells (IC50 =...