12 products were found matching "Cay313010"!

Prostaglandin E1-d4 (PGE1-d4) is intended for use as an internal standard for the quantification of PGE1 (Cay-13010) by GC- or LC-MS. PGE1 is a vasoactive prostaglandin and an active metabolite of dihomo-gamma-linolenic acid (DGLA, Cay-90230). It is formed from DGLA by COX-1 and COX-2. PGE1 is an agonist of the PGE2...

N-Acetylmuramic acid (MurNAc) is a component of the glycan strands in bacterial peptidoglycan. It is linked to N-acetylglucosamine (GlcNAc) by beta-1,4 linkages in an alternating pattern, as well as to the peptide side chains via its lactyl side chain, in native peptidoglycan.CAS Number: 10597-89-4. Synonyms:...

Thioredoxin reductase 1 inhibitor 1 (TRi-1) is an irreversible inhibitor of thioredoxin reductase 1 (TrxR1, IC50 = 0.012 µM). It inhibits TrxR1-induced reduction of Trx1 in a cell-free assay (IC50 = 4.3 µM). TRi-1 (10 µM) reduces the mitochondrial oxygen consumption rate in HCT116 colorectal cancer cells. It...

Glycoursodeoxycholic acid-d4 (GUDCA-d4) is intended for use as an internal standard for the quantification of GUDCA (Cay-21698) by GC- or LC-MS. GUDCA is a glycine-conjugated form of the secondary bile acid ursodeoxycholic acid (UDCA, Cay-15121). It has antioxidant effects in vitro in Barrett's esophagus cells and...

Lipid R6 is an ionizable cationic lipid.Formal Name: 2-((3-(diethylamino)propyl)amino)-N-undecylheptadecanamide. Molecular Formula: C35H73N3O. Formula Weight: 552.0. Purity: >98%. Formulation: (Request formulation change), A solution in ethanol. Solubility: Ethanol: 10 mg/ml. SMILES:...

Mesoridazine is an active metabolite of the typical antipsychotic thioridazine (Cay-14400). It is formed via sulfoxidation of thioridazine by the cytochrome P450 (CYP) isoform CYP2D6 in human liver microsomes. It binds to histamine H1, dopamine D2, muscarinic acetylcholine, and alpha1- and alpha2-adrenergic...

OTX008 is a small molecule topomimetic of the antiangiogenic peptide anginex and an inhibitor of galectin-1 (Gal-1). It decreases lactose binding to Gal-1 with Kd values of 290 and 100 µM in the presence and absence of OTX008, respectively, and is cytotoxic against a cancer cell panel with IC50 values that directly...

CU-76 is an inhibitor of cyclic GMP-AMP synthase (cGAS, IC50 = 0.24 µM). It reduces DNA-, but not Sendai virus-, induced dimerization of IFN regulatory factor 3 (IRF3, Cay-22811) in THP-1 cells, indicating selectivity for the cGAS DNA sensing pathway over the RIG-I-MAVS RNA sensing pathway. CU-76 decreases...

YF-2 is a histone acetyltransferase (HAT) activator. It inhibits proliferation of CCRF-CEM, Hs 578T, A549, and U251 cancer cells (IC50s = 88.7-286 µM), as well as multidrug-resistant NCI/ADR-RES cells (IC50 = 44.8 µM). YF-2 (5 mg/kg) increases reduced acetylated histone H3 levels in a mouse of model of Alzheimer's...

Phenprocoumon is an anticoagulant and vitamin K antagonist. It inhibits the activity of wild-type vitamin K epoxide reductase (VKOR, IC50 = 4.2 nM), as well as a variety of mutant VKORs (IC50s = 5.1-835 nM), in cell-based reporter assays. Phenprocoumon inhibits prothrombin complex synthesis in rats in a...

Zingibroside R1 is a triterpene saponin and an active metabolite of ginsenoside Ro (Cay-25137) that has been found in P. japonicus. It is cytotoxic to B16/F10 murine melanoma cells (IC50 = 24.52 µg/ml) and inhibits tube formation by human umbilical vein endothelial cells (HUVECs) when used at a concentration of 40...

Quercetin 3-O-beta-D-glucose-7-O-beta-D-gentiobioside is a flavonoid glycoside that has been found in L. apetalum and has lipid-lowering activity. It reduces sodium oleate-induced increases in triglyceride levels in HepG2 cells when used at a concentration of 30 µM.Formal Name:...