18 products were found matching "Cay311210"!

Prostaglandin B2 (PGB2-d4) contains four deuterium atoms at the 3, 3', 4, and 4' positions. It is intended for use as an internal standard for the quantification of PGB2 by GC- or LC-mass spectrometry. PGB2 is a non-enzymatic dehydration product resulting from the treatment of PGE2 or PGA2 with strong base. It has...

Pregnanetriol is a metabolite of 17alpha-hydroxyprogesterone (Cay-33154). It is formed from 17alpha-hydroxyprogesterone by reduction of the C-20 ketone. Urinary levels of pregnanetriol are elevated in patients with 21-hydroxylase deficiency and congenital adrenal hyperplasia.Formal Name:...

Imisopasem manganese is a nonpeptide superoxide dismutase (SOD) mimetic. It catalyzes dismutation of the superoxide anion with a catalytic rate constant of greater than 2 x 107 M-1s-1. Imisopasem manganese (1-10 mg/kg, i.v. bolus) reduces carrageenan-induced paw edema and inhibits increases in paw exudate levels of...

ASP7663 is a transient receptor potential ankyrin 1 (TRPA1) agonist. It induces calcium influx in HEK293 cells expressing human, rat, or mouse TRPA1 (EC50s = 0.51, 0.54, and 0.5 µM, respectively) and stimulates serotonin (5-HT) release from QGP-1 enterochromaffin cells that endogenously express TRPA1 (EC50 = 72.5...

5-methoxy-DL-Tryptophan (DL-5-MTP) is an active metabolite of tryptophan with anti-inflammatory and anticancer activities. It reduces LPS-induced expression of COX-2, TNF-alpha, IL-1beta, and IL-6 in RAW 264.7 macrophages when used at a concentration of 50 mM. DL-5-MTP (23.4 mg/kg) increases survival in a mouse...

[Bertin Catalog No. G01104]Clone Designation: 3C11. Host: Mouse. Isotype: IgG1, ?. Applications: ELISA, ChIP, IF, WB.

DL-Tryptophan is a racemic mixture of the atypical amino acid D-tryptophan and the essential amino acid L-tryptophan (Cay-29600). Serum levels of DL-tryptophan are negatively correlated with urinary protein levels in a rat model of nephropathy induced by doxorubicin (Cay-15007).CAS Number: 54-12-6. Synonyms: NSC...

CDN1163 is an allosteric activator of sarcoplasmic/endoplasmic reticulum Ca2+-ATPase 2 (SERCA2) that enhances calcium uptake in endoplasmic reticulum (ER) vesicles when used at concentrations ranging from 1 to 10 µM. It decreases peroxide-induced cell death in HEK293 cells. CDN1163 (50 mg/kg) increases calcium...

CCG-215022 is a G protein-coupled receptor kinase (GRK) inhibitor (IC50s = 3.9, 0.15, and 0.38 µM for GRK1, GRK2, and GRK5, respectively). It is selective for GRKs over protein kinase A (PKA, IC50 = 120 µM). CCG-215022 (500 nM) increases contractility in isoproterenol-stimulated isolated mouse cardiomyocytes. It...

DQP1105 is an NMDA receptor antagonist. It selectively inhibits glutamate-induced currents in Xenopus oocytes expressing rat NR2C and NR2D subunit-containing NMDA receptors (IC50s = 8.5 and 2.7 µM, respectively) over NR2A, NR2B, NRA1, and NRK2 subunit-containing receptors (IC50s = 206, 121, 198, and 153 µM,...

Adiphenine is an anticholinergic agent. It is an antagonist of nicotinic acetylcholine receptors (nAChRs, IC50s = 1.8, 3.7, and 6.3 µM for the alpha3beta4, alpha4beta2, and alpha4beta4 subunit-containing receptors, respectively), as well as muscarinic acetylcholine receptors (Ki = 0.44 µM). Adiphenine inhibits...

Quillaic acid is a triterpene saponin that has been found in Q. saponaria bark and has diverse biological activities. It is cytotoxic to SNU-1 and KATO III gastric cancer cells (IC50s = 13.6 and 67 µM, respectively). Quillaic acid induces hot plate analgesia in mice (ED50 = 20.7 mg/kg). It reduces ear edema induced...