- Search results for Cay20110
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5 products were found matching "Cay20110"!
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Item number: Cay20110-25
Leukotriene B4 (LTB4) is a dihydroxy fatty acid derived from arachidonic acid through the 5-LO pathway. It promotes a number of leukocyte functions including aggregation, stimulation of ion fluxes, enhancement of lysosomal enzyme release, superoxide anion production, chemotaxis, and chemokinesis. In subnanomolar...
Keywords: | LTB4, 5S,12R-dihydroxy-6Z,8E,10E,14Z-eicosatetraenoic acid |
Application: | Bioactive lipid assays |
CAS | 71160-24-2 |
MW: | 336.5 D |
From 193.00€
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Item number: Cay20000-10
SHP099 is an orally bioavailable inhibitor of SHP2, a non-receptor protein tyrosine phosphatase (IC50 = 71 nM). It stabilizes SHP2 in an auto-inhibited conformation. SHP099 suppresses signaling through the Ras-ERK pathway and blocks the proliferation of receptor tyrosine kinase-driven human cancer cells in vitro and...
Keywords: | 6-(4-amino-4-methyl-1-piperidinyl)-3-(2,3-dichlorophenyl)-2-pyrazinamine |
Application: | SHP2 inhibitor |
CAS | 1801747-42-1 |
MW: | 352.3 D |
From 60.00€
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Item number: Cay22200-10
SB-742457 is an orally bioavailable antagonist of the serotonin (5-HT) receptor subtype 5-HT6 (Ki = 1.4 nM). SB-742457 (1 µM) also binds to 5-HT1B, 5-HT2A, 5-HT2B, and 5-HT2C receptors with high affinity. SB-742457 reduces 5-HT6 activation of Gs-mediated cAMP production in a concentration-dependent manner with an...
Keywords: | GSK742457, 3-(phenylsulfonyl)-8-(1-piperazinyl)-quinoline |
Application: | 5-HT6 receptor antagonist |
CAS | 607742-69-8 |
MW: | 353.4 D |
From 50.00€
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Item number: Cay22220-10
SKF 83959 is a partial agonist at the dopamine D1-like receptors (Kis = 1.18 and 7.56 nM, respectively, for D1 and D5) that is selective over the D2-like receptors (Kis = 920 and 399 nM, respectively, for D2 and D3). It is protective against oxidative stress in retinal ganglion cells after hydrogen peroxide-induced...
Keywords: | 6-chloro-2,3,4,5-tetrahydro-3-methyl-1-(3-methylphenyl)-1H-3-benzazepine-7,8-diol, monohydrobromide |
Application: | Dopamine receptor 1 partial agonist |
CAS | 67287-95-0 |
MW: | 398.7 D |
From 32.00€
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Item number: Cay20010-50
Leukotriene A4 (LTA4) is synthesized in mast cells, eosinophils, and neutrophils from arachidonic acid by 5-lipoxygenase (5-LO), which exhibits both lipoxygenase and LTA4 synthase activities. LTA4 is rapidly metabolized by LTA4 hydrolase or LTC4 synthase to LTB4 or LTC4, respectively. LTA4, from leukocytes, is known...
Keywords: | LTA4 methyl ester, 5S-trans-5,6-oxido-7E,9E,11Z,14Z-eicosatetraenoic acid, methyl ester |
Application: | Bioactive lipid assays |
CAS | 73466-12-3 |
MW: | 332.5 D |
From 193.00€
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