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Thromboxane B3
Thromboxane B3

Item number: Cay19990-25

Thromboxane B3 (TXB3) is the stable hydrolysis product of TXA3 synthesized from eicosapentaenoic acid (EPA, Cay-90110) by COX and thromboxane synthase. It is biosynthesized in various tissues such as seminal vesicles, lung, PMNL, and ocular tissues.Formal Name: 9alpha,11,15S-trihydroxy-thromba-5Z,13E,17Z-trien-1-oic...
Keywords: TXB3, Delta17-TXB2, 9alpha,11,15S-trihydroxy-thromba-5Z,13E,17Z-trien-1-oic acid
Application: Bioactive lipid assays
CAS 71953-80-5
MW: 368.5 D
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A-769662
A-769662

Item number: Cay11900-5

A-769662 is a small molecule thienopyridone that activates AMPK directly in cell-free assays (EC50 = 116 nM) and intact cells by allosterically activating AMPK and inhibiting its dephosphorylation on Thr172. A-769662 specifically activates beta1 subunit-containing AMPK heterotrimers, and its effects are independent...
Keywords: 6,7-dihydro-4-hydroxy-3-(2'-hydroxy[1,1'-biphenyl]-4-yl)-6-oxo-thieno[2,3-b]pyridine-5-carbonitrile
Application: AMPK activator
CAS 844499-71-4
MW: 360.4 D
From 88.00€ *
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Prostaglandin B3
Prostaglandin B3

Item number: Cay11990-25

Prostaglandin B3 (PGB3) is a non-enzymatic dehydration product resulting from the treatment of Prostaglandin E3 (PGE3) with strong base. In a structure-activity binding study to determine the affinity of various prostaglandins to human PPARgamma, PGB3 exhibited a Ki value greater than 1 mM. In contrast, PGB1 and...
Keywords: PGB3, 9-oxo-15S-hydroxy-prosta-5Z,8(12),13E,17Z-tetraen-1-oic acid
Application: Bioactive lipid assays
CAS 36614-32-1
MW: 332.4 D
From 130.00€ *
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WZB117
WZB117

Item number: Cay19900-5

WZB117 is an irreversible inhibitor of glucose transporter 1 (Glut1) that blocks glucose transport in diverse cancer cells (IC50 = ~0.6 µM), reducing extracellular lactate and intracellular ATP levels. It inhibits cancer cell proliferation (IC50s = 5-10 µM), resulting in cell cycle arrest, senescence, and necrosis...
Keywords: Glucose Transporter Inhibitor IV, 3-hydroxy-benzoic acid, (3-fluoro-1,2-phenylene)ester
Application: Glucose transport inhibitor, GLUT1 inhibitor
CAS 1223397-11-2
MW: 368.3 D
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Termitomycamide B
Termitomycamide B

Item number: Cay11190-10

Endoplasmic reticulum (ER) stress, caused by accumulation of misfolded proteins and a disruption of calcium homeostasis, has been linked to several neuronal diseases including, Parkinson's, Alzheimer's, and prion diseases. A screen for protective activity against ER stress-dependent cell death identified...
Keywords: N-[2-(1H-indol-2-yl)-2-oxoethyl]-9Z,12Z-octadecadienamide
CAS 1254277-89-8
MW: 436.6 D
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11-dehydro Thromboxane B3
11-dehydro Thromboxane B3

Item number: Cay19995-50

11-dehydro TXB3 is a urinary metabolite of TXA3 in humans with enhanced dietary intake of EPA.Formal Name: (5Z)-7-[(2R,3S,4S)-tetrahydro-4-hydroxy-2-[(1E,3S,5Z)-3-hydroxy-1,5-octadien-1-yl]-6-oxo-2H-pyran-3-yl]-5-heptenoic acid. CAS Number: 129228-55-3. Synonyms: 11-dehydro TXB3. Molecular Formula: C20H30O6. Formula...
Keywords: 11-dehydro TXB3, 9alpha,15S-dihydroxy-11-oxo-thromba-5Z,13E,17Z-trien-1-oic acid
Application: Bioactive lipid assays
CAS 129228-55-3
MW: 366.5 D
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Loganin
Loganin

Item number: Cay19997-10

Loganin is an iridoid glycoside that has been found in C. fructus and has diverse biological activities. It reduces hydrogen peroxide-induced apoptosis in SH-SY5Y cells when used at concentrations ranging from 0.25 to 12.5 µM. Loganin inhibits COX-1 activity (IC50 = 3.55 µM), as well as LPS-induced TNF-alpha...
Keywords: 7-hydroxy-6-desoxy Verbenalin, NSC 606403,...
Application: Iridoid glycoside
CAS 18524-94-2
MW: 390.4 D
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AZ 3146
AZ 3146

Item number: Cay19991-10

AZ 3146 is an inhibitor of the monopolar spindle 1 (Mps1) checkpoint kinase (IC50 = 35 nM). It displays selectivity over 46 other kinases including Cdk1 and Aurora kinase B. It has been shown to inhibit the recruitment of Mad1, Mad2, and centromere protein E (CENP-E) to kinetochores. AZ 3146 can be used with...
Keywords: Mps1 Inhibitor III,...
Application: TTK / Mps1 inhibitor
CAS 1124329-14-1
MW: 452.6 D
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m-Iodobenzylguanidine (hemisulfate)
m-Iodobenzylguanidine (hemisulfate)

Item number: Cay19998-10

m-Iodobenzylguanidine (MIBG) is an analogue of norepinephrine with anticancer activity. It inhibits cell growth in a panel of human and mouse leukemia, fibrosarcoma, melanoma, and neuroblastoma cell lines when used at a concentration of 20 µg/ml and reduces clonogenic survival of L1210 leukemia cells in a...
Keywords: meta-Iodobenzylguanidine, MIBG, N-[(3-iodophenyl)methyl]-guanidine, hemisulfate
CAS 87862-25-7
MW: 324.1 D
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CCT007093
CCT007093

Item number: Cay19992-10

CCT007093 is an inhibitor of protein phosphatase 1D (PPM1D, also known as PP2Cdelta and WIP1, IC50 = 8.4 µM), which is encoded by a putative oncogene that is amplified in multiple cancer types. It does not inhibit PPM1A. CCT007093 selectively inhibits the growth of cancer cells that overexpress PPM1D, including...
Keywords: 2E,5E-bis(2-thienylmethylene)-cyclopentanone
Application: PPM1D inhibitor
CAS 176957-55-4
MW: 272.4 D
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Chromanol 293B
Chromanol 293B

Item number: Cay19993-50

Chromanol 293B is a blocker of slowly activating delayed-rectifier K+ current (IKs) with an IC50 value of 6.89 µM in Xenopus oocytes expressing rat IKs channels. It is selective, having no activity at rat Kv1.1 or Kir2.1 channels at a concentration of 30 µM. Chromanol 293B increases the rate and extent of IKs in...
Keywords: Chromanol 239B, rel-N-[(3R,4S)-6-cyano-3,4-dihydro-3-hydroxy-2,2-dimethyl-2H-1-benzopyran-4-yl]-N-methyl-ethanesulfonamide
Application: KCNQ1 channel blocker
CAS 163163-23-3
MW: 324.4 D
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Ro 4929097
Ro 4929097

Item number: Cay19996-10

Ro 4929097 is a potent inhibitor of gamma-secretase (IC50 = 4 nM) that blocks both Abeta40 and Notch processing (IC50s = 14 and 5 nM, respectively). It displays greater than 100-fold selectivity for gamma-secretase over a panel of 75 other enzymes, receptors, and ion channels. Ro 4929097 does not block tumor cell...
Keywords: N1-[(7S)-6,7-dihydro-6-oxo-5H-dibenz[b,d]azepin-7-yl]-2,2-dimethyl-N3-(2,2,3,3,3-pentafluoropropyl)-propanediamide
Application: Potent gamma-secretase inhibitor
CAS 847925-91-1
MW: 469.4 D
From 44.00€ *
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