8 products were found matching "Cay19021"!
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I-SAP
Item number: Cay19021-100
I-SAP is a high affinity TP receptor antagonist. At physiologic pH, I-SAP produces platelet shape change, but not aggregation, with an EC50 value of 9.7 nM. I-SAP binds to human platelets with the maximum binding obtained between pH 6.5 and pH 7.4. In washed human platelets, the Kd for I-SAP is 468 pM at pH 7.4 and...
| Keywords: | Iodophenyl sulfonyl amino pinane Thromboxane A2, Iodophenyl sulfonyl amino pinane TXA2,... |
| Application: | TP receptor antagonist |
| CAS | 133538-58-6 |
| MW: | 531.4 D |
From 98.00€
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ON-123300
Item number: Cay19902-1
ON-123300 is a multi-kinase inhibitor. It inhibits ARK5, Cdk4, and Cdk6 (IC50s = 3.87, 9.82, and 4.95 nM, respectively) as well as FYN, PDGFRbeta, Abl, and PI3Kdelta (IC50s = 11.09, 26, 53.32, and 144 nM, respectively) among others. It inhibits proliferation in a panel of 38 cancer cell lines (GI50s = 0.05-5 µM)....
| Keywords: | 8-cyclopentyl-7,8-dihydro-2-[[4-(4-methyl-1-piperazinyl)phenyl]amino]-7-oxo-pyrido[2,3-d]pyrimidine-6-carbonitrile |
| Application: | CDK inhibitor |
| CAS | 1357470-29-1 |
| MW: | 429.5 D |
From 50.00€
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SQ 29,548
Item number: Cay19025-1
SQ 29,548 is a highly selective TP receptor antagonist which binds to the human recombinant TP receptor with a Ki of 4.1 nM. It inhibits the aggregation of washed human platelets induced by U-46619 with an IC50 of 0.06 µM. It antagonizes U-46619 induced contraction of rat and guinea pig tracheal, arterial, and...
| Keywords: | [1S-[1alpha,2alpha(Z),3alpha,4alpha]]-7-[3-[[2-[(phenylamino)carbonyl]hydrazino]methyl]-7-oxabicyclo[2.2.1]hept-2-yl]-5-he... |
| Application: | TP receptor antagonist |
| CAS | 98672-91-4 |
| MW: | 387.5 D |
From 114.00€
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AH 23848 (calcium salt)
Item number: Cay19023-1
Thromboxane (TXA2) activates the T prostanoid (TP) receptor. Prostaglandin E2 (PGE2) activates four E prostanoid (EP) receptors, EP1-4. AH 23848 is a dual antagonist of TP and EP4 receptors. It originally was found to inhibit TXA2-induced platelet aggregation (IC50 = 0.26 µM) and the contraction of human bronchial...
| Keywords: | (4Z)-rel-7-[(1R,2R,5S)-5-([1,1'-biphenyl]-4-ylmethoxy)-2-(4-morpholinyl)-3-oxocyclopentyl]-4-heptenoic acid, hemicalcium salt |
| Application: | TP receptor antagonist, EP4 receptor antagonist |
| CAS | 81496-19-7 |
| MW: | 496.6 D |
From 110.00€
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Amitriptyline (hydrochloride)
Item number: Cay19029-1
Amitriptyline (hydrochloride) (Cay-19029) is an analytical reference material categorized as a tricyclic antidepressant. This product is intended for analytical forensic applications. This product is also available as a general research tool (Cay-15881).Formal Name:...
| Keywords: | NIH 10794, Ro 4-1575, 3-(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-ylidene)-N,N-dimethyl-1-propanamine, monohydrochloride |
| Application: | Analytical reference material, Tricyclic antidepressant |
| CAS | 549-18-8 |
| MW: | 313.9 D |
From 28.00€
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Pinane Thromboxane A2
Item number: Cay19020-1
Pinane thromboxane A2 (PTA2) is a stable analog of TXA2. It is a TP receptor antagonist and an inhibitor of thromboxane synthase. PTA2 inhibits U-46619-induced cat coronary artery constriction (ID50 = 0.1 µM), U-46619-induced aggregation of human platelets (IC50 = 2 µM), and rabbit platelet thromboxane synthase...
| Keywords: | 15(S)-Pinane Thromboxane A2, Pinane TXA2, PTA2,... |
| Application: | Thromboxane synthase inhibitor |
| CAS | 71111-01-8 |
| MW: | 376.6 D |
From 98.00€
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Nortriptyline (hydrochloride) (CRM)
Item number: Cay19042-1
Nortriptyline (hydrochloride) (CRM) (Cay-19042) is a certified reference material categorized as an antidepressant. Nortriptyline is an active metabolite of amitriptyline (Cay-19031, Cay-19029). It decreases immobility time in the forced swim test in rats and has antinociceptive activity in mice. Nortriptyline...
| Keywords: | 3-(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-ylidene)-N-methyl-1-propanamine, monohydrochloride |
| Application: | Certified reference material categorized, antidepressant, SNRI |
| CAS | 894-71-3 |
| MW: | 299.8 D |
36.00€
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S 2101
Item number: Cay19802-1
S 2101 is an inhibitor of lysine-specific demethylase 1 (LSD1, Ki = 0.61 µM). It is selective for LSD1 over monoamine oxidase A (MAO-A) and MAO-B (Kis = 17 and 110 µM, respectively).Formal Name: (1R,2S)-rel-2-[3,5-difluoro-2-(phenylmethoxy)phenyl]-cyclopropanamine, monohydrochloride. CAS Number: 1239262-36-2....
| Keywords: | KDM1 inhibitor II, LSD1 inhibitor II, Lysine-specific Demethylase 1 Inhibitor II,... |
| Application: | LSD1 inhibitor |
| CAS | 1239262-36-2 |
| MW: | 311.8 D |
From 50.00€
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