10 products were found matching "Cay18300"!

PGI3 is synthesized from EPA by COX and PGI synthase. PGI3 has a short in vivo half-life and is hydrolyzed to Delta17-6-keto PGF1alpha. The platelet and vascular activity of PGI3 is equivalent to that of PGI2.Formal Name: 6,9alpha-epoxy-11alpha,15S-dihydroxy-prosta-5Z,13E,17Z-trien-1-oic acid, monosodium salt. CAS...

GDC-0980 is a potent inhibitor of class I phosphatidylinositol 3-kinase (PI3K) isoforms, with IC50 values of 5, 27, 7, and 14 nM for PI3Kalpha, beta, delta, and gamma, respectively, in cell-free assays. It also inhibits mTOR (Ki = 17 nM) but is inactive against a large panel of additional kinases. GDC-0980 induces...

Naltrexone-d3 (Cay-18325) is an analytical reference material intended for use as an internal standard for the quantification of naltrexone (Cay-ISO60192, Cay-15520) by GC- or LC-MS. Naltrexone is categorized as an opioid antagonist. Formulations containing naltrexone have been used in the treatment of alcohol...

6beta-Naltrexol-d3 (Cay-18350) is an analytical reference material intended for use as an internal standard for the quantification of 6beta-naltrexol (Cay-15896) by GC- or LC-MS. 6beta-Naltrexol is the major metabolite of naltrexone (Cay-ISO60192, Cay-15520). It is a neutral µ-opioid receptor antagonist (Ki = 94...

Inhibition of cardiac late sodium current (late INa) is a strategy to suppress arrhythmias and sodium-dependent calcium overload associated with myocardial ischemia and heart failure. GS967 is a selective inhibitor of late INa that has been shown to suppress experimentally induced arrhythmias in rabbit myocytes and...

N6-Methyladenosine (m6A) is an abundant modification found in mRNA, tRNA, snRNA, as well as long non-coding RNA, in all species. RNA adenosine methylation is catalyzed by a multicomponent complex composed of METTL3/MT-A70, METTL14, and WTAP in mammals. METTL3 and METTL14 are responsible for the methyltransferase...

PSI-6206 is the deaminated derivative of PSI-6130, a selective inhibitor of hepatitis C virus (HCV) replication that targets the NS5B polymerase. PSI-6206, itself, does not inhibit HCV replication in the HCV subgenomic replicon assay. However, its triphosphate form, RO 2433-TP, does inhibit RNA synthesis by HCV...

The mammalian target of rapamycin (mTOR) is a serine-threonine kinase that is central to two protein complexes, mTORC1 and mTORC2. These complexes are differentially regulated (e.g., only mTORC1 is sensitive to rapamycin (Cay-13346)) and regulate different pathways. WYE-125132 is an ATP-competitive inhibitor of mTOR...

Eicosapentaenoic acid (EPA, Cay-90110) is metabolized, in part, through cytochrome P450-catalyzed epoxidation followed by conversion to the vicinal diols by epoxide hydrolases. (±)5(6)-DiHETE (Cay-10467) is a possible metabolite produced from EPA following epoxidation of the alpha-5 double bond. (±)5(6)-DiHETE...

NVP-BEP800 is an inhibitor of heat shock protein 90 (Hsp90, IC50 = 58 nM for recombinant human Hsp90beta). It is selective for Hsp90 over the chaperones GRP94 and TRAP1 (IC50s = 4.1 and 5.5 µM, respectively). NVP-BEP800 inhibits the growth of BT474, SK-BR-3, MCF-7, MDA-MB-157, MDA-MB-231, MDA-MB-468, and BT-20...