14 products were found matching "Cay18211"!

Bacopaside II is a triterpene glycoside found in B. monnieri that has neuroprotective, anti-angiogenic, and anticancer activities. Bacopaside II (0.4 mg/ml) decreases hydrogen peroxide-induced intracellular reactive oxygen species (ROS) production and cell death in N2a neuroblastoma cells. It decreases immobility...

Sp-5,6-dichloro-cBIMPS is a benzimidazole monophosphorothioate that acts as a potent activator of protein kinase A (PKA, Ki = 30 nM). It is selective for PKA over PKG (Ki = 10 µM). Sp-5,6-dichloro-cBIMPS is also resistant to degradation by cyclic nucleotide phosphodiesterases. It displays good cell permeability and...

Cyclic GMP (cGMP) is a second messenger that is biosynthesized from GTP by guanylate cyclases. Activators of guanylate cyclases include nitric oxide and natriuretic peptides. cGMP activates protein kinase G (PKG) and modulates ion channel conductance, with signaling affecting diverse processes including smooth...

Bacopaside I is a saponin that has been found in B. monniera and has diverse biological activities. It inhibits monoamine oxidase A (MAO-A) and MAO-B (IC50s = 17.08 and 94.22 µg/ml, respectively). Bacopaside I (5, 15, and 50 mg/kg) decreases immobility time in the tail suspension and forced swim tests, as well as...

Iloprost is a second generation structural analog of prostacyclin (PGI) with about ten-fold greater potency than the first generation stable analogs, typified by carbaprostacyclin. Iloprost binds with equal affinity to the human recombinant IP and EP1 receptors with a Ki of 11 nM. Iloprost constricts the isolated...

Carbaprostacyclin is a structural analog of prostacyclin (PGI2) with about 1/10 the receptor binding affinity of prostacyclin. Carbaprostacyclin is a relatively indiscriminant ligand for prostaglandin receptors, binding to all the recombinant human PG receptors, except the TP receptor, with an affinity which is a...

Ciprostene is the 9beta-methyl analog of carbaprostacyclin and a stable analog of PGI2. Ciprostene exhibits biological activity similar to PGI2, but is 30-fold less potent. In patas monkeys, ciprostene induces hypotension and causes tachycardia when administered at a dose of 0.16 µg/kg/min. In addition, ciprostene...

Commendamide is a natural bacterial product that was discovered in a screen for commensal bacteria effector genes (Cbegs). Cbeg12 is a bacterial effector gene that encodes for its production. Commendamide is structurally similar to long-chain N-acyl-amides, which commonly signal, in mammals, through G...

Cancer cell survival appears partly dependent on antioxidative enzymes, whose expression is regulated by the Keap1-Nrf2 pathway, to quench potentially toxic reactive oxygen species generated by their metastatic transformation. AEM1 is an inhibitor of gene expression induced by nuclear erythroid 2-related factor 2...

Deoxycholic acid (DCA) is a secondary bile acid that is formed via microbial transformation of cholic acid (Cay-20250) in the colon. It can be conjugated to glycine or taurine (Cay-27031) to produce glycodeoxycholic acid (GDCA, Cay-20274) or taurodeoxycholic acid (TDCA, Cay-15935), respectively, in hepatocytes. DCA...

Donepezil-d4 is intended for use as an internal standard for the quantification of donepezil (Cay-13245) by GC- or LC-MS. Donepezil is an inhibitor of acetylcholinesterase (AChE, IC50 = 6.7 nM). It is selective for AChE over butyrylcholinesterase (BChE, IC50 = 988 nM). Donepezil (0.1 and 1 µM) inhibits the...

SR 2595 is an inverse agonist of PPARgamma (IC50 = 30 nM) that represses both transactivation in a promoter:reporter assay and expression of the adipogenic marker fatty acid-binding protein 4 in differentiating murine preadipocytes. Repression of PPARgamma with SR 2595 promotes osteogenesis, as measured by calcium...