6 products were found matching "Cay18120"!
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6beta-Prostaglandin I1
Item number: Cay18120-10
6beta-PGI1 is a stable PGI2 analog resistant to hydrolysis in aqueous solutions. 6beta-PGI1 has a much longer half-life than PGI2, but a greatly reduced molar potency for receptor mediated function. 6beta-PGI1 has a Kact for adenylate cyclase in NCB-20 cells of 4.2 µM compared with 18 nM for PGI2. The potency for...
| Keywords: | 5,6beta-dihydro PGI2, 6beta-PGI1, 6S,9alpha-epoxy-11alpha,15S-dihydroxy-prost-13E-en-1-oic acid |
| Application: | Bioactive lipid assays |
| CAS | 62770-50-7 |
| MW: | 354.5 D |
From 86.00€
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Avasimibe
Item number: Cay18129-10
Acyl-Coenzyme A:cholesterol acyltransferases (ACAT1 and ACAT2) catalyze the formation of cholesterol esters from cholesterol and long chain fatty acyl-coenzyme A, and may play a role in the development of atherosclerosis. Avasimibe is an orally bioavailable inhibitor of ACAT (IC50s = 24 and 9.2 µM for ACAT1 and...
| Keywords: | Cl-1011, PD-148515, 2,6-bis(1-methylethyl)phenyl ester N-[2-[2,4,6-tris(1-methylethyl)phenyl]acetyl]-sulfamic acid |
| Application: | ACAT inhibitor |
| CAS | 166518-60-1 |
| MW: | 501.7 D |
From 66.00€
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Elacridar
Item number: Cay18128-10
Elacridar is a dual inhibitor of P-glycoprotein (MRP-1, ABCB1) and breast cancer resistance protein (BCRP, ABCG2). It maximally inhibits P-glycoprotein in isolated human peripheral blood leukocytes at 200 nM. Elacridar blocks the activity of P-glycoprotein at the blood-brain barrier, altering the pharmacokinetics of...
| Keywords: | GF120918, GG918, GW0918,... |
| Application: | ABCB1 inhibitor, ABCG2 inhibitor |
| CAS | 143664-11-3 |
| MW: | 563.6 D |
From 43.00€
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UNC2327
Item number: Cay18122-10
UNC2327 is an allosteric inhibitor of protein arginine methyltransferase 3 (PRMT3, IC50 = 230 nM).Formal Name: N-1,2,3-benzothiadiazol-6-yl-N'-[2-oxo-2-(1-piperidinyl)ethyl]-urea. CAS Number: 1426152-53-5. Molecular Formula: C14H17N5O2S. Formula Weight: 319.4. Purity: >98%. Formulation: (Request formulation change),...
| Keywords: | N-1,2,3-benzothiadiazol-6-yl-N'-[2-oxo-2-(1-piperidinyl)ethyl]-urea |
| Application: | PRMT3 inhibitor |
| CAS | 1426152-53-5 |
| MW: | 319.4 D |
From 64.00€
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GSK5959
Item number: Cay18123-10
The bromodomain and PHD finger-containing (BRPF) proteins are scaffolding components of chromatin-binding MOZ/MORF histone acetyltransferase complexes, which have activity as transcriptional regulators. BRPF1 (BR140 or Peregrin) is important for maintaining Hox gene expression and the development of multiple...
| Keywords: | N-[2,3-dihydro-1,3-dimethyl-2-oxo-6-(1-piperidinyl)-1H-benzimidazol-5-yl]-2-methoxy-benzamide |
| Application: | Cell-permeable BRPF1 bromodomain inhibitor |
| CAS | 901245-65-6 |
| MW: | 394.5 D |
From 43.00€
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RN-1 (hydrochloride)
Item number: Cay18124-10
Lysine-specific demethylase 1 (LSD1) belongs to the family of flavin adenine dinucleotide (FAD)-dependent amine oxidases that include monoamine oxidases (MAOs). RN-1 is a potent, irreversible inhibitor of LSD1 (IC50 = 70 nM). It is much less effective against MAO-A and MAO-B (IC50s = 0.51 and 2.8 µM, respectively)....
| Keywords: | LSD1 Inhibitor IV, rel-1-(4-methyl-1-piperazinyl)-2-[[(1R,2S)-2-[4-(phenylmethoxy)phenyl]cyclopropyl]amino]-ethanone,... |
| Application: | Irreversible LSD1 inhibitor |
| CAS | 1781835-13-9 |
| MW: | 452.4 D |
From 77.00€
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