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Item number: Cay18133-25

Human mutT homolog (MTH1) is a nucleotide pool sanitizing enzyme that cleaves oxidized nucleotides (dNTPs) to prevent incorporation of damaged bases during DNA replication. Cancer cells rely on MTH1 activity in order to avoid cell death. TH588 is an MTH1 inhibitor (IC50 = 5 nM) with improved metabolic stability over...

Keywords:	N4-cyclopropyl-6-(2,3-dichlorophenyl)-2,4-pyrimidinediamine
Application:	MTH1 inhibitor
CAS	1609960-31-7
MW:	295.2 D

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