3 products were found matching "Cay18113"!
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YM-53601
Item number: Cay18113-500
YM-53601 is a squalene synthase inhibitor (IC50s = 79 and 90 nM in HepG2 cells and rat liver microsomes, respectively). It inhibits cholesterol biosynthesis in rats (ED50 = 32 mg/kg). YM-53601 dose-dependently reduces plasma triglyceride and non-HDL cholesterol levels in hamsters fed both normal and high-fat diets....
| Keywords: | 2-[(2E)-2-(1-azabicyclo[2.2.2]oct-3-ylidene)-2-fluoroethoxy]-9H-carbazole, monohydrochloride |
| Application: | Squalene synthase inhibitor |
| CAS | 182959-33-7 |
| MW: | 372.9 D |
From 278.00€
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Rosuvastatin (calcium salt)
Item number: Cay18813-10
Rosuvastatin is an inhibitor of HMG-CoA reductase (IC50 = 5 nM). It inhibits cholesterol synthesis in isolated rat hepatocytes with an IC50 value of 0.16 nM. Rosuvastatin (10 mg/kg) reduces plasma total cholesterol, triglyceride, LDL-C, and oxidized LDL-C levels in Ldlr-/- mice fed a high-fat diet. It decreases the...
| Keywords: | (3R,5S,6E)-7-[4-(4-fluorophenyl)-6-(1-methylethyl)-2-[methyl(methylsulfonyl)amino]-5-pyrimidinyl]-3,5-dihydroxy-6-heptenoi... |
| Application: | HMG-CoA reductase inhibitor |
| CAS | 147098-20-2 |
| MW: | 500.6 D |
From 43.00€
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TH588
Item number: Cay18133-1
Human mutT homolog (MTH1) is a nucleotide pool sanitizing enzyme that cleaves oxidized nucleotides (dNTPs) to prevent incorporation of damaged bases during DNA replication. Cancer cells rely on MTH1 activity in order to avoid cell death. TH588 is an MTH1 inhibitor (IC50 = 5 nM) with improved metabolic stability over...
| Keywords: | N4-cyclopropyl-6-(2,3-dichlorophenyl)-2,4-pyrimidinediamine |
| Application: | MTH1 inhibitor |
| CAS | 1609960-31-7 |
| MW: | 295.2 D |
From 43.00€
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