6 products were found matching "Cay170265-%25"!

5-Aminosalicylic acid (5-ASA) is a non-steroidal anti-inflammatory drug (NSAID) and an active metabolite of sulfasalazine (Cay-15025), balsalazide (Cay-18680), and olsalazine (Cay-23661). It is formed from these prodrugs by bacterial azoreductases in the intestinal lumen. 5-ASA selectively inhibits COX-2 over COX-1...

Inflachromene is an anti-inflammatory agent that directly binds high mobility group protein 1 (HMGB1) and HMGB2 and reduces their cytoplasmic accumulation in microglial cells. It is functional in vivo, downregulating proinflammatory functions of HMGB proteins and reducing neuronal damage. Inflachromene also...

The transduction of neurobehavioral effects by serotonin (5-hydroxy tryptamine, 5-HT) is mediated by at least seven major 5-HT receptor subtypes. SB-224289 is a potent 5-HT1B inverse agonist (pKi = 8.16) that displays >75-fold selectivity for human 5-HT1B over all other 5-HT receptors. It has been used to study the...

Cefapirin is a first generation cephalosporin antibiotic that is broadly effective against gram-negative and gram-positive bacteria. The bactericidal action of cefapirin results from inhibition of cell-wall synthesis, mediated by its binding to penicillin binding proteins. It is mainly used in veterinary medicine...

IC261 is a reversible, ATP-competitive inhibitor of casein kinase 1 (CK1) that inhibits CK1delta and CK1? (IC50 = ~1 µM for both), as well as CK1alpha (IC50 = 16 µM). It is at least 100-fold less effective against PKA, p34cdc2, and p55fyn. IC 261, at 1 µM, inhibits cytokinesis in primary mouse embryo fibroblasts....

Tigecycline is a broad-spectrum glycylcycline antibiotic that binds to the bacterial 30S ribosome, blocking the entry of transfer RNA, which halts protein synthesis and inhibits bacterial growth. It is active against a panel of 1,924 European clinical bacterial isolates including S. aureus, S. epidermidis, S....