- Search results for Cay16950
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18 products were found matching "Cay16950"!
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Item number: Cay16950-50
20-hydroxy Prostaglandin F2alpha (20-hydroxy PGF2alpha) is the omega-oxidation product of PGF2alpha. Cultured type II alveolar cells from pregnant rabbits metabolize exogenous PGF2alpha via microsomal cytochrome P450 omega-oxidation, producing 20-hydroxy PGF2alpha and its 15-hydroxy PGDH metabolites. Cells from male...
Keywords: | 20-hydroxy PGF2alpha, 9alpha,11alpha,15S,20-tetrahydroxy-prosta-5Z,13E-dien-1-oic acid |
Application: | Bioactive lipid assays |
CAS | 57930-92-4 |
MW: | 370.5 D |
From 86.00€
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Item number: Cay16958-50
MPP+ is an active metabolite of MPTP, a neurotoxin used to cause selective destruction of dopaminergic neurons in animal models of parkinsonism. MPP+ induces neurotoxicity primarily by inhibiting complex I of the mitochondrial electron transport chain, resulting in ATP depletion and increased oxidative stress. The...
Keywords: | N-Methyl-4-Phenylpyridinium Iodide, 1-methyl-4-phenyl-pyridinium, monoiodide |
Application: | Neurotoxin, oxidative stress inducer |
CAS | 36913-39-0 |
MW: | 297.1 D |
From 65.00€
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Item number: Cay16942-50
Glycochenodeoxycholic acid (GCDCA) is a glycine-conjugated form of the primary bile acid chenodeoxycholic acid (Cay-10011286). It reduces formation of cholic acid (Cay-20250) in primary human hepatocytes when used at a concentration of 100 µM. GCDCA (50, 75, and 100 µM) reduces the number of LC3 puncta, a marker of...
Keywords: | GCDCA, NSC 681056, N-[(3alpha,5beta,7alpha)-3,7-dihydroxy-24-oxocholan-24-yl]-glycine, monosodium salt, hydrate |
Application: | Biosurfactant |
MW: | 471.6 D |
From 43.00€
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Item number: Cay16954-10
Indole-3-acetic acid is an auxin plant growth regulator that is found in all higher-order plants. It reduces plant height and shoot growth in tomato plants when used at concentrations of 10 and 50 µM. Root saturation with indole-3-acetic acid-loaded nanoparticles increases rooting efficiency in P....
Keywords: | Heteroauxin, IAA, 1H-indole-3-acetic acid, monosodium salt |
Application: | Plant hormone |
CAS | 6505-45-9 |
MW: | 197.2 D |
From 43.00€
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Item number: Cay16989-50
Dabrafenib is an ATP-competitive inhibitor of Raf kinases (IC50s = 0.64, 0.68, and 5 nM for wild-type B-RAF kinase, mutant B-RAFV600E, and wild-type C-RAF kinase, respectively). It also inhibits the tyrosine kinase-like kinases ALK5 and LIMK1 (IC50s = 11 and 15 nM, respectively) and the calcium/calmodulin-dependent...
Keywords: | GSK2118436,... |
Application: | B-Raf V600E inhibitor |
CAS | 1195765-45-7 |
MW: | 519.6 D |
From 48.00€
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Item number: Cay16951-10
Sanguinarine is a benzylisoquinoline alkaloid isolated from plants belonging to the family Papaveraceae. It exhibits antimicrobial, anti-inflammatory, and anti-oxidant properties and demonstrates antiproliferative and pro-apoptotic effects in some cancer cell lines. Sanguinarine suppresses NF-kappaB activation by...
Keywords: | 13-methyl-[1,3]benzodioxolo[5,6-c]-1,3-dioxolo[4,5-i]phenanthridinium, monochloride |
Application: | Benzylisoquinoline alkaloid |
CAS | 5578-73-4 |
MW: | 367.8 D |
From 43.00€
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Item number: Cay16934-50
Doripenem is a broad-spectrum antibiotic in the beta-lactam subclass known as carbapenems. It is active against Gram-negative and Gram-positive bacteria, including S. aureus, S. pneumoniae, E. coli, and K. pneumoniae (MICs = 0.03-0.06, 0.016-0.06, P. aeruginosa respiratory tract infection when administered at a dose...
Keywords: | S 4661,... |
Application: | Antibiotic |
CAS | 1820954-21-9 |
MW: | 420.5 D |
From 69.00€
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Item number: Cay16949-50
1,3,7-Trimethyluric acid is a derivative of uric acid (Cay-16219) and a metabolite of caffeine (Cay-14118). It is formed from caffeine by the cytochrome P450 (CYP) isoform CYP3A4. 1,3,7-Trimethyluric acid (500 µM) scavenges hydroxyl radicals in a cell-free assay and inhibits t-butyl hydroperoxide-induced lipid...
Keywords: | 8-oxo Caffeine, NSC 11259, NSC 95858, TMU, 7,9-dihydro-1,3,7-trimethyl-1H-purine-2,6,8(3H)-trione |
Application: | Caffeine consumption marker |
CAS | 5415-44-1 |
MW: | 210.2 D |
From 84.00€
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Item number: Cay16978-50
AZD 8055 is a potent, selective ATP-competitive inhibitor of mTOR, exhibiting an IC50 value of 0.8 nM. It is ~1,000-fold selective for mTOR over all PI3K isoforms and exhibits no activity against a panel of 260 kinases at concentrations up to 10 µM. AZD 8055 inhibits proliferation of A549 and H838 cells with IC50...
Keywords: | CCG-168, 5-[2,4-bis[(3S)-3-methyl-4-morpholinyl]pyrido[2,3-d]pyrimidin-7-yl]-2-methoxy-benzenemethanol |
Application: | mTOR inhibitor |
CAS | 1009298-09-2 |
MW: | 465.5 D |
From 60.00€
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Item number: Cay16957-10
Guanosine 5'-monophosphate is a nucleotide used in the synthesis of RNA. Upon phosphorylation to GTP, it becomes incorporated into RNA by various RNA polymerases. It can be used to study modulation of glutamatergic neurotransmission.Formal Name: 5'-guanylic acid, disodium salt. CAS Number: 5550-12-9. Synonyms: GMP,...
Keywords: | 5'-GMP, 5'-Guanylic Acid, NSC 20265, 5'-guanylic acid, disodium salt |
Application: | Glutamatergic neurotransmission modulation studies |
CAS | 5550-12-9 |
MW: | 407.2 D |
From 65.00€
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Item number: Cay16910-50
19(R)-hydroxy PGF2alpha is an omega-1 hydroxylase metabolite of PGF2alpha found in human semen. The concentration of 19(R)-hydroxy PGF compounds (F2alpha and F1alpha together) in fresh human semen is about 20 µg/ml. 19(R)-hydroxy PGF2alpha exhibits no activity at the FP receptor of the cat iris sphincter muscle at...
Keywords: | 19(R)-hydroxy PGF2alpha, 9alpha,11alpha,15S,19R-tetrahydroxy-prosta-5Z,13E-dien-1-oic acid |
Application: | Bioactive lipid assays |
CAS | 64625-53-2 |
MW: | 370.5 D |
From 74.00€
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Item number: Cay16945-50
SCH 202676 is a reversible inhibitor of both agonist and antagonist binding to diverse G protein-coupled receptors (GPCRs). It blocks the binding of radiolabeled ligands to human opioid, adrenergic, muscarinic, dopaminergic, adenosine, and purinergic receptors. It displays IC50 values of 0.1 to 1.8 µM for modulating...
Keywords: | N-(2,3-diphenyl-1,2,4-thiadiazol-5(2H)-ylidene)-methanamine, monohydrobromide |
Application: | GPCR antagonist / agonist binding inhibitor |
CAS | 265980-25-4 |
MW: | 348.3 D |
From 84.00€
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