- Search results for Cay16940
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10 products were found matching "Cay16940"!
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Item number: Cay16940-5
20-ethyl Prostaglandin F2alpha (20-ethyl PGF2alpha) is an analog of PGF2alpha in which the omega-chain has been extended by the addition of two more methylene carbon atoms. It is therefore a modified version of the clinically approved glaucoma medication unoprostone. Unoprostone also contains lower side chain...
Keywords: | 20-ethyl PGF2alpha, ICI 74205, 9alpha,11alpha,15S-trihydroxy-20a,20b-dihomoprosta-5Z,13E-dien-1-oic acid |
Application: | Bioactive lipid assays |
CAS | 36950-85-3 |
MW: | 382.5 D |
From 86.00€
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Item number: Cay16942-50
Glycochenodeoxycholic acid (GCDCA) is a glycine-conjugated form of the primary bile acid chenodeoxycholic acid (Cay-10011286). It reduces formation of cholic acid (Cay-20250) in primary human hepatocytes when used at a concentration of 100 µM. GCDCA (50, 75, and 100 µM) reduces the number of LC3 puncta, a marker of...
Keywords: | GCDCA, NSC 681056, N-[(3alpha,5beta,7alpha)-3,7-dihydroxy-24-oxocholan-24-yl]-glycine, monosodium salt, hydrate |
Application: | Biosurfactant |
MW: | 471.6 D |
From 43.00€
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Item number: Cay16948-10
Acetyl-L-carnitine is an acetylated form of the essential mitochondrial metabolite L-carnitine (Cay-21489) that is catabolized by plasma esterases into carnitine. Acetyl-L-carnitine facilitates the uptake of acetyl-CoA into mitochondria during fatty acid oxidation, enhances acetylcholine production, and stimulates...
Keywords: | L-Acetylcarnitine, ALCAR, 2R-(acetyloxy)-3-carboxy-N,N,N-trimethyl-1-propanaminium, monochloride |
CAS | 5080-50-2 |
MW: | 239.7 D |
From 43.00€
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Item number: Cay16949-50
1,3,7-Trimethyluric acid is a derivative of uric acid (Cay-16219) and a metabolite of caffeine (Cay-14118). It is formed from caffeine by the cytochrome P450 (CYP) isoform CYP3A4. 1,3,7-Trimethyluric acid (500 µM) scavenges hydroxyl radicals in a cell-free assay and inhibits t-butyl hydroperoxide-induced lipid...
Keywords: | 8-oxo Caffeine, NSC 11259, NSC 95858, TMU, 7,9-dihydro-1,3,7-trimethyl-1H-purine-2,6,8(3H)-trione |
Application: | Caffeine consumption marker |
CAS | 5415-44-1 |
MW: | 210.2 D |
From 84.00€
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Item number: Cay16945-50
SCH 202676 is a reversible inhibitor of both agonist and antagonist binding to diverse G protein-coupled receptors (GPCRs). It blocks the binding of radiolabeled ligands to human opioid, adrenergic, muscarinic, dopaminergic, adenosine, and purinergic receptors. It displays IC50 values of 0.1 to 1.8 µM for modulating...
Keywords: | N-(2,3-diphenyl-1,2,4-thiadiazol-5(2H)-ylidene)-methanamine, monohydrobromide |
Application: | GPCR antagonist / agonist binding inhibitor |
CAS | 265980-25-4 |
MW: | 348.3 D |
From 84.00€
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Item number: Cay16946-10
7,8-Dihydroxyflavone (7,8-DHF) is a flavone that has been found in G. aesculifolia and has diverse biological activities. It binds to tropomyosin-related kinase B (TrkB, Kd = 320 nM) and induces TrkB autophosphorylation in primary mouse hippocampal neurons. In vivo, 7,8-DHF (5 mg/kg) reduces neuronal apoptosis and...
Keywords: | 7,8-DHF, 7,8-dihydroxy-2-phenyl-4H-1-benzopyran-4-one |
Application: | TrkB agonist |
CAS | 38183-03-8 |
MW: | 254.2 D |
From 43.00€
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Item number: Cay16947-10
N-desmethyl Imatinib is a major active metabolite of imatinib (Cay-13139), an anticancer agent that selectively targets tyrosine kinases, including Bcr-ABL, platelet-derived growth factor receptor (PDGFR), and KIT. N-desmethyl Imatinib is formed when imatinib undergoes demethylation by the cytochrome P450 (CYP)...
Keywords: | N-Desmethyl Gleevec, STI-509-00,... |
Application: | Major active imatinib metabolite, Tyrosine kinase inhibitor |
CAS | 404844-02-6 |
MW: | 479.6 D |
From 52.00€
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Item number: Cay16944-10
(-)-Gallocatechin ((-)-GC) is an epimer of (-)-epigallocatechin ((-)-EGC, Cay-11809). They are flavan-3-ols and members of the catechin family of polyphenolic antioxidants found in green tea and other plant extracts. Both (-)-GC and (-)-EGC are potent antioxidants and significantly inhibit the proliferation of...
Keywords: | (-)-GC, (2S,3R)-3,4-dihydro-2-(3,4,5-trihydroxyphenyl)-2H-1-benzopyran-3,5,7-triol |
Application: | Antioxidant |
CAS | 3371-27-5 |
MW: | 306.3 D |
From 50.00€
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Item number: Cay16941-10
Glutamate, the major excitatory neurotransmitter in the CNS, activates eight known subtypes of metabotropic glutamate receptors (mGluRs). Highly selective modulators designed to act at allosteric sites on certain mGluR subtypes are being developed to preferentially regulate subtype-specific, glutamate-induced...
Keywords: | 3-chloro-N-[3-chloro-4-(4-chloro-1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)phenyl]-2-pyridinecarboxamide |
Application: | Selective positive mGluR1 allosteric modulator |
CAS | 1623101-11-0 |
MW: | 446.7 D |
From 66.00€
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Lipid-based Drug Delivery Tools
Item number: Cay16943-50
DC-Chol is a cationic cholesterol derivative. DC-Chol, as a component of lipoplexes with 1,2-Dioleoyl-sn-glycero-3-PE (1,2-DOPE, Cay-15091), has been used for transfection of mRNA into A549 cells without affecting cell viability. Incubation of DC-chol/1,2-DOPE liposomes or lipoplexes with human whole blood has no...
Keywords: | Cholesteryl 3beta-N-(dimethylaminoethyl)carbamate, (3beta)-cholest-5-en-3-ol 3-[N-[2-(dimethylamino)ethyl]carbamate],... |
Application: | Cationic cholesterol derivative, transfection |
CAS | 166023-21-8 |
MW: | 537.3 D |
From 85.00€
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