- Search results for Cay16825-%25
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14 products were found matching "Cay16825-%25"!
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Item number: Cay16827-25
N-undecanoyl-L-Homoserine lactone is a bacterial quorum-sensing signaling molecule. It induces GFP production in an E. coli reporter strain expressing the V. fischeri LuxR-PluxI quorum-sensing operon when used at concentrations ranging from 100 to 1,000 nM. N-undecanoyl-L-Homoserine lactone also inhibits the...
Keywords: | C11-HSL, N-[(3S)-tetrahydro-2-oxo-3-furanyl]-undecanamide |
Application: | Bioactive lipid assays |
CAS | 216596-71-3 |
MW: | 269.4 D |
From 60.00€
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Item number: Cay16872-25
I-BET726 is an inhibitor of BET family proteins that binds BRD2, BRD3, and BRD4 with high affinity (IC50s = 41, 31, and 22 nM, respectively) and competes with tetra-acetylated histone 4 peptides for binding to the bromodomains of these proteins. It exhibits >1,000-fold selectivity for these proteins over other...
Keywords: | GSK1324726A, 4-[(2S,4R)-1-acetyl-4-[(4-chlorophenyl)amino]-1,2,3,4-tetrahydro-2-methyl-6-quinolinyl]-benzoic acid |
Application: | BET protein inhibitor |
CAS | 1300031-52-0 |
MW: | 435 D |
From 56.00€
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Item number: Cay16248-25
Ezatiostat is an inhibitor of glutathione S-transferase pi 1-1 (GSTP1-1, Ki = 0.4 µM). It is selective for GSTP1-1 over GSTalpha and GSTµ family GSTs (Kis = 20-75 µM). Ezatiostat also inhibits the protein-protein interaction between GSTP1-1 and JNK1. In vivo, ezatiostat (75 mg/kg) increases the number of circulating...
Keywords: | Terrapin 199, TLK199, (2R)-L-gamma-glutamyl-S-(phenylmethyl)-L-cysteinyl-2-phenyl-glycine-1,3-diethyl ester |
Application: | GSTP1-1 inhibitor |
CAS | 168682-53-9 |
MW: | 529.7 D |
From 43.00€
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Item number: Cay16871-25
Lipopolysaccharides (LPS) are components of the cell walls of Gram-negative bacteria. LPS is composed of polysaccharides and lipid A, where lipid A is a phosphoglycolipid containing acyl chains composed of 10 to 16 carbons. The lipid A component of LPS is detected by Toll-like receptor 4 of mammalian leukocytes and,...
Keywords: | 3(R)-hydroxy Tetradecanoic Acid, 3R-hydroxy-tetradecanoic acid |
Application: | Lipid A component |
CAS | 28715-21-1 |
MW: | 244.4 D |
From 131.00€
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Item number: Cay16891-25
GSK690693 is an ATP-competitive, pan-Akt kinase inhibitor with IC50 values of 2, 13, and 9 nM for Akt1, 2, and 3, respectively. It also inhibits other members of the AGC kinase family, including AMPK, DAPK3, PAKs, PKA, PKC, PKG, and PrkX (IC50 values range from 2-81 nM). By preventing the phosphorylation of...
Keywords: | 4-[2-(4-amino-1,2,5-oxadiazol-3-yl)-1-ethyl-7-[(3S)-3-piperidinylmethoxy]-1H-imidazo[4,5-c]pyridin-4-yl]-2-methyl-3-butyn-... |
Application: | Akt kinase inhibitor |
CAS | 937174-76-0 |
MW: | 425.5 D |
From 66.00€
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Item number: Cay16258-25
Phosphorylation of eIF2alpha by several kinases in response to cellular stress, including accumulation of unfolded proteins in the ER, results in a decrease in overall protein synthesis but upregulation of a small number of key regulatory proteins. trans-ISRIB (Integrated Stress Response Inhibitor) is a symmetric...
Keywords: | N,N'-((1r,4r)-cyclohexane-1,4-diyl)bis(2-(4-chlorophenoxy)acetamide) |
Application: | EIF2AK3 / PERK inhibitor |
CAS | 1597403-47-8 |
MW: | 451.3 D |
From 109.00€
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Item number: Cay16948-25
Acetyl-L-carnitine is an acetylated form of the essential mitochondrial metabolite L-carnitine (Cay-21489) that is catabolized by plasma esterases into carnitine. Acetyl-L-carnitine facilitates the uptake of acetyl-CoA into mitochondria during fatty acid oxidation, enhances acetylcholine production, and stimulates...
Keywords: | L-Acetylcarnitine, ALCAR, 2R-(acetyloxy)-3-carboxy-N,N,N-trimethyl-1-propanaminium, monochloride |
CAS | 5080-50-2 |
MW: | 239.7 D |
From 43.00€
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Item number: Cay16178-25
WHI-P154 is a quinazoline derivative that exhibits immunosuppressive effects by selectively inhibiting JAK3 (IC50 = 1.8 µM versus IC50s > 10 µM for JAK1 and JAK2). It has been reported to inhibit additional kinases including EGFR (IC50 = 4 nM) and VEGFR as well as the non-receptor tyrosine kinases, Abl, Lck, and...
Keywords: | JAK3 Inhibitor II, Janus-Associated Kinase 3 Inhibitor II, 2-bromo-4-[(6,7-dimethoxy-4-quinazolinyl)amino]-phenol |
Application: | JAK3 inhibitor |
CAS | 211555-04-3 |
MW: | 376.2 D |
From 109.00€
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Item number: Cay16338-25
SR 11302 is a synthetic retinoid that inhibits AP-1 activity without activating transcription through RARE. It significantly suppresses both AP-1 activation and phorbol ester-induced papilloma formation in mice when applied topically (0.1 µM). SR 11302 is used to elucidate the role of AP-1 in various signaling...
Keywords: | (2E,4E,6Z,8E)-3-methyl-7-(4-methylphenyl)-9-(2,6,6-trimethyl-1-cyclohexen-1-yl)-2,4,6,8-nonatetraenoic acid |
Application: | AP-1 inhibitor |
CAS | 160162-42-5 |
MW: | 376.5 D |
From 60.00€
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Item number: Cay16938-25
Tomatidine is a steroidal alkaloid that has been found in the skins and leaves of tomatoes. It suppresses NF-kappaB signaling in LPS-stimulated macrophages, blocking induced expression of inducible nitric oxide synthase (iNOS) and COX-2. Tomatidine inhibits acid sphingomyelinase activity by 84.2% when used at a...
Keywords: | (3beta,5alpha,22beta,25S)-spirosolan-3-ol, monohydrochloride |
Application: | Steroidal alkaloid |
CAS | 6192-62-7 |
MW: | 452.1 D |
From 48.00€
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Item number: Cay11861-25
Brefeldin A (BFA) is a natural fungal metabolite which has been used extensively to study intracellular transport by vesicles or endosomes. Early studies demonstrated that BFA reversibly interferes with protein trafficking and secretion mediated by the Golgi apparatus and endoplasmic reticulum. BFA directly and...
Keywords: | Ascotoxin, BFA, Cyanein, Decumbin, Nectrolide, NSC 107456, NSC 244390, NSC 56310, NSC 89671, Synergisidin,... |
Application: | Endosomal trafficking studies |
CAS | 20350-15-6 |
MW: | 280.4 D |
From 46.00€
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Item number: Cay19866-25
Quercitrin is a glycoside formed from the flavonoid quercetin (Cay-10005169) and the deoxy sugar rhamnose. It can be found in a wide range of medicinal plants and has been reported to have antioxidant, antiviral, and anti-inflammatory properties.Formal Name:...
Keywords: | C.I. 75720, NSC 9221, Quercetin 3-L-rhamnoside, Quercetin 3-rhamnoside,... |
Application: | Antioxidant, Antiviral, Antiinflammatory agent |
CAS | 522-12-3 |
MW: | 448.4 D |
From 43.00€
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