13 products were found matching "Cay16825"!

15(R)-17-phenyl trinor Prostaglandin F2alpha isopropyl ester (15(R)-17-phenyl trinor PGF2alpha isopropyl ester) is the latanoprost-related isomer containing both a double bond at 13,14 and an inverted (beta) hydroxyl group at C-15. Similar to 15(S)-latanoprost, 15(R)-17-phenyl trinor PGF2alpha isopropyl ester is a...

Clozapine-N-oxide is a major metabolite of clozapine (Cay-12059) and an activator of designer receptors exclusively activated by designer drugs (DREADDs) derived from human muscarinic acetylcholine receptors (EC50s = 16.7, 323, 17.4, 18.3, and 18.7 nM for PASMCs expressing hM1-5D receptors, respectively). It...

P7C3 is an orally bioavailable and brain penetrant aminopropyl carbazole that exhibits proneurogenic and neuroprotective activity by preventing apoptosis of newly postmitotic neurons in the subgranular zone of the hippocampal dentate gyrus. At doses of 5 mg/kg and above, it has been shown to promote the survival of...

The asarones, including alpha-asarone (Cay-11681) and beta-asarone, were first isolated from volatile oils of plants of the genus Acorus, which are used in Ayurvedic medicine. beta-Asarone is noted for its neuroprotective effects, as it ameliorates depression, reduces dopamine-induced neurotoxicity, and attenuates...

Latanoprost ethyl amide (Lat-NEt) is a latanoprost analog in which the C-1 carboxyl group has been modified to an N-ethyl amide. Prostaglandin esters have been shown to have ocular hypotensive activity. Prostaglandin N-ethyl amides were recently introduced as alternative prostaglandin ocular hypotensive prodrugs....

17-phenyl trinor Prostaglandin F2alpha ethyl amide (17-phenyl trinor PGF2alpha ethyl amide) is an F-series prostaglandin derivative and an agonist of FP receptors. It induces calcium mobilization in 3T3-L1 fibroblasts expressing the human receptors (EC50 = 2.2 µM). Ocular administration of 17-phenyl trinor PGF2alpha...

N-undecanoyl-L-Homoserine lactone is a bacterial quorum-sensing signaling molecule. It induces GFP production in an E. coli reporter strain expressing the V. fischeri LuxR-PluxI quorum-sensing operon when used at concentrations ranging from 100 to 1,000 nM. N-undecanoyl-L-Homoserine lactone also inhibits the...

17-phenyl trinor Prostaglandin F2alpha diethyl amide (17-phenyl trinor PGF2alpha diethyl amide) is an analog of PGF2alpha in which the C-1 carboxyl group has been modified to an N-diethyl amide. PG esters have been shown to have ocular hypotensive activity. PG N-ethyl amides were recently introduced as alternative...

17-phenyl trinor PGF2alpha N-ethyl amide is an F-series prostaglandin analog which has been approved for use as an ocular hypotensive drug, sold under the Allergan trade name Bimatoprost. The N-ethyl amide prostaglandin prodrugs are converted to the active free acid more slowly than the analogous prostaglandin ester...

17-phenyl trinor Prostaglandin F2alpha amide (17-phenyl trinor PGF2alpha amide) is an F-series PG analog in which the C-1 carboxyl group has been modified to an unsubstituted amide. PG esters have been shown to have ocular hypotensive activity. PG N-ethyl amides were recently introduced as alternative PG hypotensive...

Lipopolysaccharides (LPS) are components of the cell walls of Gram-negative bacteria. LPS is composed of polysaccharides and lipid A, where lipid A is a phosphoglycolipid containing acyl chains composed of 10 to 16 carbons. The lipid A component of LPS is detected by Toll-like receptor 4 of mammalian leukocytes and,...

I-BET726 is an inhibitor of BET family proteins that binds BRD2, BRD3, and BRD4 with high affinity (IC50s = 41, 31, and 22 nM, respectively) and competes with tetra-acetylated histone 4 peptides for binding to the bromodomains of these proteins. It exhibits >1,000-fold selectivity for these proteins over other...