11 products were found matching "Cay16815"!

15-keto Latanoprost (free acid) is a metabolite of latanoprost (Cay-16812). It is formed from latanoprost (free acid) via dehydrogenation at position 15 by 15-hydroxyprostaglandin dehydrogenase in monkey cornea.Formal Name: (5Z)-7-[(1R,2R,3R,5S)-3,5-dihydroxy-2-(3-oxo-5-phenylpentyl)cyclopentyl]-5-heptenoic acid....

Latanoprost (free acid) is a derivative of prostaglandin F2alpha (PGF2alpha, Cay-16010, Cay-16020), an FP receptor agonist, and an active metabolite of the prodrug latanoprost (Cay-16812). It selectively binds to the FP receptor (Ki = 0.098 µM) over the EP1, EP2, EP3, and EP4 receptors (Kis = 2.06, 39.667, 7.519,...

Unoprostone isopropyl ester is an ocular hypotensive agent, a prodrug form of the FP receptor agonist unoprostone (Cay-16680), and a derivative of prostaglandin F2alpha (PGF2alpha, Cay-16010, Cay-16020). It inhibits contractions induced by the peptide vasoconstrictor endothelin-1 (Cay-24127) in isolated porcine...

alpha-Asarone is a component of certain essential oils used in traditional Chinese herbal medicine. Although carcinogenic, alpha-asarone has been shown to be neuroprotective and radioprotective in mice when given at 50 mg/kg. It also lowers serum cholesterol in rats, specifically reducing LDL-cholesterol levels and...

15(S)-Latanoprost is an analog of latanoprost in which the hydroxyl at carbon 15 is inverted relative to latanoprost. The IC50 values for the free acid forms of latanoprost and 15(S)-latanoprost were determined to be 3.6 nM and 24 nM, respectively, in a FP receptor binding assay using the cat iris sphincter muscle....

15-keto Latanoprost is an active metabolite of the FP receptor agonist latanoprost (Cay-16812). Intraocular administration of 15-keto latanoprost (1 µg/eye) reduces intraocular pressure in cynomolgus monkeys. It also reduces pupillary diameter in cats when administered topically at a dose of 5 µg/eye. 15-keto...

Latanoprost is a derivative of prostaglandin F2alpha (PGF2alpha, Cay-16010, Cay-16020), an FP receptor agonist, and a prodrug of latanoprost (free acid) (Cay-16811). It induces phosphoinositide turnover in isolated human ciliary muscle and human trabecular meshwork cells, HEK293 cells expressing human ocular FP...

17-phenyl trinor Prostaglandin F2alpha (17-phenyl trinor PGF2alpha) is a metabolically stable analog of PGF2alpha and is a potent agonist for the FP receptor. It binds to the FP receptor on ovine luteal cells with a relative potency of 756% compared to that of PGF2alpha. At the rat recombinant FP receptor expressed...

5-trans Latanoprost is a derivative of the FP receptor agonist latanoprost (free acid) (Cay-16811) and the trans isomer of latanoprost (Cay-16812). Like other trans isomers of F-type prostaglandins, 5-trans latanoprost may have similar FP receptor activation and intraocular pressure reduction activities as the cis...

15(R)-17-phenyl trinor Prostaglandin F2alpha (15(R)-17-phenyl trinor PGF2alpha) is the 15(R) isomer of the FP receptor agonist 17-phenyl trinor PGF2alpha (Cay-16810). 17-phenyl trinor PGF2alpha is an active metabolite of the prodrug 17-phenyl trinor PGF2alpha ethyl amide (Cay-16820). It is formed from 17-phenyl...

15-keto-17-phenyl trinor Prostaglandin F2alpha (15-keto-17-phenyl trinor PGF2alpha) is a keto derivative of an F-series prostaglandin and a metabolite of the prostaglandin FP receptor agonist 17-phenyl trinor PGF2alpha ethyl amide (Cay-16820). It is formed from 17-phenyl trinor PGF2alpha ethyl amide by...