16 products were found matching "Cay16811"!

Latanoprost (free acid) is a derivative of prostaglandin F2alpha (PGF2alpha, Cay-16010, Cay-16020), an FP receptor agonist, and an active metabolite of the prodrug latanoprost (Cay-16812). It selectively binds to the FP receptor (Ki = 0.098 µM) over the EP1, EP2, EP3, and EP4 receptors (Kis = 2.06, 39.667, 7.519,...

3,4-Methylenedioxycathinone (hydrochloride) (Cay-16688) is an analytical reference standard categorized as a cathinone. This product is intended for research and forensic applications.Formal Name: 2-amino-1-(1,3-benzodioxol-5-yl)-1-propanone, monohydrochloride. CAS Number: 38061-37-9. Molecular Formula: C10H11NO3 ....

XLR11 (Cay-11565) is a synthetic cannabinoid (CB) featuring a tetramethylcyclopropyl group, which reportedly confers selectivity for the peripheral CB2 receptor over the central CB1 receptor. XLR11 also has an N-(5-fluoropentyl) chain, which increases binding to both CB receptors. XLR11 N-(4-pentenyl) analog is a...

11-keto-beta-Boswellic acid is a naturally occurring pentacyclic triterpene isolated from the gum resin exudate from the stem of the tree B. serrata (frankincense). Boswellic acids are specific, non-redox inhibitors of leukotriene synthesis via 5-lipoxygenase that demonstrate anti-inflammatory and anti-arthritic...

Pyr3 is a pyrazole compound that selectively antagonizes the transient receptor potential canonical channel 3 (TRPC3). It inhibits TRPC3-mediated Ca2+ influx with an IC50 value of 0.7 µM without effect on other TRPC members and suppresses activation of nuclear factor of activated T cells with an IC50 value of 0.05...

The kinesin-like spindle protein Eg5, also known as KSP and Kif11, is a motor protein that is essential for establishing a bipolar spindle during mitosis. Eg5-I is a potent inhibitor of Eg5, both in vitro and in cells (IC50s = 127 and 190 nM, respectively). It is an analog of S-trityl-L-cysteine (STLC), but is more...

alpha-Asarone is a component of certain essential oils used in traditional Chinese herbal medicine. Although carcinogenic, alpha-asarone has been shown to be neuroprotective and radioprotective in mice when given at 50 mg/kg. It also lowers serum cholesterol in rats, specifically reducing LDL-cholesterol levels and...

Unoprostone isopropyl ester is an ocular hypotensive agent, a prodrug form of the FP receptor agonist unoprostone (Cay-16680), and a derivative of prostaglandin F2alpha (PGF2alpha, Cay-16010, Cay-16020). It inhibits contractions induced by the peptide vasoconstrictor endothelin-1 (Cay-24127) in isolated porcine...

15(S)-Latanoprost is an analog of latanoprost in which the hydroxyl at carbon 15 is inverted relative to latanoprost. The IC50 values for the free acid forms of latanoprost and 15(S)-latanoprost were determined to be 3.6 nM and 24 nM, respectively, in a FP receptor binding assay using the cat iris sphincter muscle....

15-keto Latanoprost is an active metabolite of the FP receptor agonist latanoprost (Cay-16812). Intraocular administration of 15-keto latanoprost (1 µg/eye) reduces intraocular pressure in cynomolgus monkeys. It also reduces pupillary diameter in cats when administered topically at a dose of 5 µg/eye. 15-keto...

17-phenyl trinor Prostaglandin F2alpha (17-phenyl trinor PGF2alpha) is a metabolically stable analog of PGF2alpha and is a potent agonist for the FP receptor. It binds to the FP receptor on ovine luteal cells with a relative potency of 756% compared to that of PGF2alpha. At the rat recombinant FP receptor expressed...

Latanoprost is a derivative of prostaglandin F2alpha (PGF2alpha, Cay-16010, Cay-16020), an FP receptor agonist, and a prodrug of latanoprost (free acid) (Cay-16811). It induces phosphoinositide turnover in isolated human ciliary muscle and human trabecular meshwork cells, HEK293 cells expressing human ocular FP...