6 products were found matching "Cay16787-%25"!

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15-keto Fluprostenol isopropyl ester
15-keto Fluprostenol isopropyl ester

Item number: Cay16786-25

Travoprost is an F-series prostaglandin analog which has been approved for use as an ocular hypotensive drug. Oxidation of the C-15 hydroxyl group without isopropyl ester hydrolysis produces 15-keto fluprostenol isopropyl ester (15-keto travoprost). 15-keto Travoprost is a potential metabolite of travoprost when...
Keywords: 15-keto Travoprost,...
Application: Bioactive lipid assays
CAS 404830-45-1
MW: 498.5 D
From 118.00€ *
Review
Oxolinic Acid
Oxolinic Acid

Item number: Cay16789-25

Bacterial DNA gyrase is a heterodimeric type II topoisomerase that negatively supercoils circular double-stranded DNA. Oxolinic acid is a quinolone antibiotic that inhibits bacterial DNA gyrase, but not eukaryotic topoisomerases, reversibly binding gyrase subunit A in gyrase-DNA complexes, blocking supercoiling...
Keywords: NSC 110364, Urinox, 5-ethyl-5,8-dihydro-8-oxo-1,3-dioxolo[4,5-g]quinoline-7-carboxylic acid
Application: Antibiotic, Gyrase inhibitor
CAS 14698-29-4
MW: 261.2 D
From 43.00€ *
Review
Baricitinib
Baricitinib

Item number: Cay16707-25

Baricitinib is an inhibitor of JAK1 and JAK2 (IC50s = 0.0059 and 0.0057 µM, respectively). It is selective for JAK1 and JAK2 over JAK3, TYK2, c-Met, and checkpoint kinase 2 (Chk2, IC50s = >0.4, 0.053, >10, and >1 µM, respectively). Baricitinib inhibits IL-6-induced phosphorylation of STAT3 in isolated human...
Keywords: INCB 028050, LY3009104, 1-(ethylsulfonyl)-3-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]-3-azetidineacetonitrile
Application: JAK1 / JAK2 inhibitor
CAS 1187594-09-7
MW: 371.4 D
From 50.00€ *
Review
U-104
U-104

Item number: Cay16717-25

Carbonic anhydrases are zinc metalloenzymes that catalyze the reversible hydration of carbon dioxide to form bicarbonate ion plus a proton. Carbonic anhydrases IX (CAIX) and CAXII are hypoxia and HIF-1-inducible proteins located in cellular transmembranes that regulate intra- and extracellular pH under hypoxic...
Keywords: NSC 213841, 4-[[[(4-fluorophenyl)amino]carbonyl]amino]-benzenesulfonamide
Application: CAIX / CAXII inhibitor
CAS 178606-66-1
MW: 309.3 D
From 65.00€ *
Review
Tideglusib
Tideglusib

Item number: Cay16727-25

Tideglusib is a thiadiazolidinone that prevents inflammation and neurodegeneration when injected into rat hippocampus concurrently with kainic acid, a compound that causes excitotoxicity. Tideglusib-induced neuroprotection, in this model, is attenuated by the PPARgamma antagonist GW9662 (Cay-70785). Interestingly,...
Keywords: NP031112, 2-(1-naphthalenyl)-4-(phenylmethyl)-1,2,4-thiadiazolidine-3,5-dione
Application: Neuroprotective, GSK3beta inhibitor
CAS 865854-05-3
MW: 334.4 D
From 44.00€ *
Review
5-methyl Chrysene
5-methyl Chrysene

Item number: Cay18677-25

5-methyl Chrysene is a carcinogenic polycyclic aromatic hydrocarbon consisting of four fused rings and acts as an aryl hydrocarbon receptor agonist. It is produced by the incomplete combustion of organic matter and found primarily in gasoline exhaust and tobacco smoke. 5-methyl Chrysene can be activated to mutagenic...
Keywords: NSC 407620, 5-methyl-chrysene
Application: AH receptor agonist
CAS 3697-24-3
MW: 242.3 D
From 205.00€ *
Review