7 products were found matching "Cay16767-%25"!
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Fluprostenol
Item number: Cay16768-25
Fluprostenol is a metabolically stable analog of PGF2alpha with potent FP receptor agonist activity. Fluprostenol is the optically active enantiomer of fluprostenol and would be expected to have twice the potency as the racemic mixture. Fluprostenol inhibits PGF2alpha binding to human and rat FP receptors with IC50...
| Keywords: | 16-m-trifluoromethylphenoxy tetranor Prostaglandin F2alpha,... |
| Application: | FP receptor agonist |
| CAS | 54276-17-4 |
| MW: | 458.5 D |
From 86.00€
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Baricitinib
Item number: Cay16707-25
Baricitinib is an inhibitor of JAK1 and JAK2 (IC50s = 0.0059 and 0.0057 µM, respectively). It is selective for JAK1 and JAK2 over JAK3, TYK2, c-Met, and checkpoint kinase 2 (Chk2, IC50s = >0.4, 0.053, >10, and >1 µM, respectively). Baricitinib inhibits IL-6-induced phosphorylation of STAT3 in isolated human...
| Keywords: | INCB 028050, LY3009104, 1-(ethylsulfonyl)-3-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]-3-azetidineacetonitrile |
| Application: | JAK1 / JAK2 inhibitor |
| CAS | 1187594-09-7 |
| MW: | 371.4 D |
From 50.00€
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U-104
Item number: Cay16717-25
Carbonic anhydrases are zinc metalloenzymes that catalyze the reversible hydration of carbon dioxide to form bicarbonate ion plus a proton. Carbonic anhydrases IX (CAIX) and CAXII are hypoxia and HIF-1-inducible proteins located in cellular transmembranes that regulate intra- and extracellular pH under hypoxic...
| Keywords: | NSC 213841, 4-[[[(4-fluorophenyl)amino]carbonyl]amino]-benzenesulfonamide |
| Application: | CAIX / CAXII inhibitor |
| CAS | 178606-66-1 |
| MW: | 309.3 D |
From 65.00€
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Tideglusib
Item number: Cay16727-25
Tideglusib is a thiadiazolidinone that prevents inflammation and neurodegeneration when injected into rat hippocampus concurrently with kainic acid, a compound that causes excitotoxicity. Tideglusib-induced neuroprotection, in this model, is attenuated by the PPARgamma antagonist GW9662 (Cay-70785). Interestingly,...
| Keywords: | NP031112, 2-(1-naphthalenyl)-4-(phenylmethyl)-1,2,4-thiadiazolidine-3,5-dione |
| Application: | Neuroprotective, GSK3beta inhibitor |
| CAS | 865854-05-3 |
| MW: | 334.4 D |
From 44.00€
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Astragaloside A
Item number: Cay16677-50
Astragalosides are bioactive saponins isolated from dried roots of plants of the genus Astragalus, which is used in traditional Chinese medicine. Astragaloside A is known to have diverse protective effects for the cardiovascular, immune, digestive, and nervous systems. More specifically, it protects cardiomyocytes...
| Keywords: | AS-A, AST-A, Astramembrannin I,... |
| Application: | Bioactive saponin |
| CAS | 83207-58-3 |
| MW: | 785 D |
From 77.00€
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WS3
Item number: Cay17667-25
WS3 is a non-specific proliferative molecule that modulates the activity of Erb3 binding protein-1 and the IkappaB kinase pathway. It has been used to mediate proliferation of primary retinal pigment epithelial cells ex vivo in order to provide a renewable source of cells for transplantation in a model of retinal...
| Keywords: | N-[6-[4-[[[[4-[(4-methyl-1-piperazinyl)methyl]-3-(trifluoromethyl)phenyl]amino]carbonyl]amino]phenoxy]-4-pyrimidinyl]-cycl... |
| Application: | EBP1 / PA2G4 modulator |
| CAS | 1421227-52-2 |
| MW: | 569.6 D |
From 84.00€
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LOC14
Item number: Cay17766-25
LOC14 is an inhibitor of protein disulfide isomerase (PDI, Kd = 62 nM). It inhibits PDI chaperone activity in an insulin aggregation assay when used at a concentration of 75 µM. LOC14 reduces PC12 cell death induced by the misfolded huntingtin protein mHTTQ103 (EC50 = 500 nM). It reduces medium spiny neuron (MSN)...
| Keywords: | 2-[[4-(cyclopropylcarbonyl)-1-piperazinyl]methyl]-1,2-benzisothiazol-3(2H)-one |
| Application: | PDI inhibitor |
| CAS | 877963-94-5 |
| MW: | 317.4 D |
From 125.00€
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