16 products were found matching "Cay16750"!

16,16-dimethyl PGF2alpha is a metabolically stable analog of PGF2alpha. It binds to the FP receptor on ovine luteal cells with slightly better affinity (159%) than PGF2alpha.Formal Name: 9alpha,11alpha,15R-trihydroxy-16,16-dimethyl-prosta-5Z,13E-dien-1-oic acid. CAS Number: 39746-23-1. Synonyms: 16,16-dimethyl...

Buphedrone is a substituted cathinone, analogous to methcathinone, which has been identified in products that are sold as stimulants. 4-methyl-N-Methylbuphedrone (hydrochloride) is a para-methyl analog of buphedrone with an aminomethyl addition. Its biological and toxicological properties are not known. This product...

Astragalosides are bioactive saponins isolated from dried roots of plants of the genus Astragalus, which is used in traditional Chinese medicine. Astragaloside A is known to have diverse protective effects for the cardiovascular, immune, digestive, and nervous systems. More specifically, it protects cardiomyocytes...

Aloe-emodin is a hydroxyanthraquinone found in Aloe vera leaves that has potent laxative action by inducing chloride secretion in colonic mucosa and releasing acetylcholine, which stimulates contraction of intestinal smooth muscle. It also demonstrates anti-tumor activity (ED50s = 1-13 µM), inducing apoptosis in...

5-trans Fluprostenol isopropyl ester (5-trans Travoprost) is a potential impurity in commercial preparations of the PGF2alpha analog and prodrug form of (+)-fluprostenol travoprost (fluprostenol isopropyl ester).Formal Name:...

Biocytin is a conjugate of biotin and lysine known formally as ?-N-(d-biotinyl)-L-lysine. The addition of lysine to biotin increases the chain length extending from biotin, allowing the synthesis of medium-chain reagents. It also provides terminal carboxyl and amino groups for derivatization or conjugation to...

Peroxisome proliferator-activated receptors (PPARs) are activated by fatty acids and eicosanoids as well as antidyslipidemic agents. Among the receptor isotypes, PPARalpha demonstrates a particular role in fatty acid oxidation whereas PPARgamma is known to be involved in adipocyte differentiation and lipid storage....

Deferasirox is an orally bioavailable synthetic, tridentate iron chelator that binds iron at a 2:1 ratio. It is selective for iron (Fe(III)) over Cu(II), Zn(II), Mg(II), and Ca(II) but does bind to Al(III). Deferasirox decreases iron levels in iron-loaded rat heart cells in vitro by 45.8 and 55.6% compared to...

GPR81, also known as hydroxycarboxylic acid receptor 1 (HCAR1), is a recently de-orphanized receptor that is activated by lactic acid (EC50 ~ 1.5 mM) but not by other hydroxycarboxylic acids. 3-chloro-5-hydroxy BA is an agonist of GPR81 (EC50 = 16 µM) that is inactive against the related GPR109a (HCAR2) receptor. It...

2,3-dinor Fluprostenol is a derivative of the FP receptor agonist and prostaglandin F2alpha (PGF2alpha, Cay-16010, Cay-16020) analog fluprostenol (Cay-16768).Formal Name: (+)-9alpha,11alpha,15R-trihydroxy-16-(3-(trifluoromethyl)phenoxy)-2,3,17,18,19,20-hexanor-prosta-5Z,13E-dien-1-oic acid. Molecular Formula:...

Fudosteine is a cysteine derivative that interferes with the increase in goblet cell number, expression of the mucin MUC5AC, and subsequent mucin secretion, in airways agonized with tobacco smoke, isoproterenol, lipopolysaccharide, TNF-alpha, or oxidants. Fudosteine, which is a thiol compound with antioxidant...

Tideglusib is a thiadiazolidinone that prevents inflammation and neurodegeneration when injected into rat hippocampus concurrently with kainic acid, a compound that causes excitotoxicity. Tideglusib-induced neuroprotection, in this model, is attenuated by the PPARgamma antagonist GW9662 (Cay-70785). Interestingly,...