- Search results for Cay16735
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5 products were found matching "Cay16735"!
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Item number: Cay16735-1
AL 8810 is an 11beta-fluoro analog of PGF2alpha which acts as a potent and selective antagonist at the FP receptor. AL 8810 has weak intrinsic agonist activity on FP receptor preparations in the 200-300 nM range, yet it fully antagonizes the activity of the potent FP receptor agonist fluprostenol at this...
Keywords: | 9alpha,15R-dihydroxy-11beta-fluoro-15-(2,3-dihydro-1H-inden-2-yl)-16,17,18,19,20-pentanor-prosta-5Z,13E-dien-1-oic acid |
Application: | FP receptor antagonist |
CAS | 246246-19-5 |
MW: | 402.5 D |
From 141.00€
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Item number: Cay16733-5
1-Azakenpaullone is an analog of kenpaullone (Cay-10010239) that inhibits glycogen synthase kinase 3beta (GSK3beta) more potently (IC50 = 18 nM) than CDK1/cyclin B or CDK5/p25 (IC50s = 2.0 and 4.2 µM, respectively). Through its effects on GSK3beta, 1-azakenpaullone stimulates the proliferation of human pancreatic...
Keywords: | 9-bromo-7,12-dihydro-pyrido[3',2':2,3]azepino[4,5-b]indol-6(5H)-one |
Application: | GSK3beta inhibitor |
CAS | 676596-65-9 |
MW: | 328.2 D |
From 123.00€
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Item number: Cay11673-5
alpha-acetyl Boswellic acid is a pentacyclic triterpene and isomer of beta-acetyl-boswellic acid (Cay-11674) originally isolated from B. serrata. It inhibits LPS-induced TNF-alpha mRNA expression in monocytes as well as NF-kappaB activity in HEK293 cells when used at a concentration of 10 µM. alpha-acetyl Boswellic...
Keywords: | 3-O-acetyl-alpha-Boswellic Acid, ABA, alpha-Boswellic Acid Acetate, (3alpha,4beta)-3-(acetyloxy)-olean-12-en-23-oic acid |
CAS | 89913-60-0 |
MW: | 498.7 D |
From 125.00€
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Item number: Cay16731-5
Janus-associated kinases (JAKs) are cytoplasmic tyrosine kinases that are required for activating the signaling of certain cytokines and growth factor receptors. Many myeloproliferative diseases have been linked to a mutation in JAK2 where a switch from valine to phenylalanine occurs at the 617 position (V617F)....
Keywords: | 5-fluoro-2-[[(1S)-1-(4-fluorophenyl)ethyl]amino]-6-[(5-methyl-1H-pyrazol-3-yl)amino]-3-pyridinecarbonitrile |
Application: | JAK2 inhibitor |
CAS | 905586-69-8 |
MW: | 354.4 D |
From 158.00€
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Item number: Cay16732-5
Janus kinases (JAKs) are non-receptor kinases that mediate signaling through cytokine receptors, often to members of the signal transducer and activator of transcription family. CEP-33779 is a potent, orally available inhibitor of JAK2 (IC50 = 1.3 nM). It shows 65-fold selectivity for JAK2 over JAK3. In mouse models...
Keywords: | N-[3-(4-methyl-1-piperazinyl)phenyl]-8-[4-(methylsulfonyl)phenyl]-[1,2,4]triazolo[1,5-a]pyridin-2-amine |
Application: | JAK2 inhibitor |
CAS | 1257704-57-6 |
MW: | 462.6 D |
From 92.00€
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