7 products were found matching "Cay16685-%25"!

P7C3 is an orally bioavailable and brain penetrant aminopropyl carbazole that exhibits proneurogenic and neuroprotective activity by preventing apoptosis of newly postmitotic neurons in the subgranular zone of the hippocampal dentate gyrus. At doses of 5 mg/kg and above, it has been shown to promote the survival of...

BYL719 is an inhibitor of phosphoinositide 3-kinase alpha (PI3Kalpha, IC50s = 4.6, 4, and 4.8 nM for wild-type, E545K mutant, and H1047R mutant PI3K, respectively). It is selective for PI3Kalpha over PI3Kbeta, PI3Kdelta, PI3Kgamma, and PI4Kbeta (IC50s = 1,156, 290, 250, and 581 nM, respectively), as well as VPS34,...

Erythromycin is a macrolide antibiotic that inhibits bacterial protein synthesis by targeting the 50S ribosomal subunit, blocking the progression of nascent polypeptide chains. It is active against a host of bacterial genera, including Streptococcus, Staphylococcus, and Haemophilus (MIC90s = 0.015-2.0 mg/l)....

15-keto Fluprostenol isopropyl ester is an ester derivative of the FP receptor agonist fluprostenol (Cay-16768) that is oxidized at carbon 15. It is a potential inactive metabolite of fluprostenol isopropyl ester (travoprost, Cay-16769) based on the published metabolism of latanoprost (Cay-16812) by...

CAY10685 is a cell-active analog of the lysine acetyltransferase inhibitor CPTH2 (Cay-12086) that contains an alkyne moiety for use in click chemistry reactions. Its ability to inhibit N-acetyltransferase 10 activity has been used to modulate chromatin organization in order to study changes in nuclear architecture...

Ponasterone A is an analog of 20-hydroxy ecdysone (Cay-16145), the insect steroid hormone that regulates the metamorphosis of Drosophila. Ecdysteroids such as this compound have been employed as inducers of ecdysone-inducible mammalian expression systems.Formal Name:...

NNGH is a cell-permeable, broad-spectrum inhibitor of matrix metalloproteinases (MMPs). It blocks the activity of MMP-8, -9, -12, -13, and -20 with Ki values of 9, 2.6, 4.3, 3.1, and 17 nM, respectively. It also inhibits MMP-1, -3, -7, and -10 with Ki values of 0.17, 0.13, 13, and 0.1 µM, respectively. It is...