11 products were found matching "Cay16670"!

13,14-dihydro-15-keto Prostaglandin F2alpha (13,14-dihydro-15-keto PGF2alpha) is the first prominent plasma metabolite of PGF2alpha in the 15-hydroxy PGDH pathway. Measurement of 13,14-dihydro-15-keto PGF2alpha in plasma can be used as a marker of the in vivo production of PGF2alpha.Formal Name:...

16-phenyl tetranor Prostaglandin F2alpha (16-phenyl tetranor PGF2alpha) is a metabolically stable analog of PGF2alpha. The affinity of 16-phenyl tetranor PGF2alpha at the FP receptor of ovine luteal cells is poor (8.7%) compared to PGF2alpha.Formal Name:...

Goat anti-Mouse IgG, secondary antibody, conjugated to DyLight(R) 488Antibody: Goat polyclonal anti-Mouse IgG Dye: DyLight(R) 488 Excitation max. lambda: 493 nm Emission max. lambda: 518 nm Uses: Flow Cytometry, flurorescence-activated cell sorting, and protein microarrays Form: Conjugate supplied as a liquid in...

14-deoxy-11,12-didehydro Andrographolide is an analog of the natural diterpenoid andrographolide (Cay-11679) that can be isolated from A. paniculata. It retains the anti-inflammatory, antiallergenic, immuno-stimulatory, antiviral, antioxidant, hepatoprotective, and cardiovascular activities of andrographolide...

Bone morphogenetic proteins (BMP) are secreted signaling proteins, many of which are involved in various developmental processes, in addition to bone formation. DMH1 is an analog of the non-selective BMP receptor inhibitor dorsomorphin (Cay-11967) that potently inhibits the kinase activity of activin receptor-like...

Rhodamine 123 is a membrane-permeable cationic dye that is readily accumulated within living cells. It is a substrate for the efflux pump P-glycoprotein (P-gp, also known as multidrug resistance protein 1 and ABCB1) and is rapidly exported from cells with functional P-gp. As P-gp is expressed on a population of stem...

Activation of bone morphogenetic protein (BMP) type I receptors, also known as activin receptor-like kinases (ALK1-7), leads to the assembly of SMAD complexes, which translocate to the nucleus to induce transcriptional activation important for normal development and tissue repair. K02288 is a 2-aminopyridine-based...

The two isoforms of glycogen synthase kinase 3, GSK3alpha and GSK3beta, constitutively phosphorylate and inactivate glycogen synthase, preventing glycogen synthesis. They also phosphorylate proteins that are relevant to Alzheimer's disease and osteogenesis. AZD 1080 is a potent, brain permeable inhibitor of...

Flupirtine is an activator of voltage-gated potassium channel 7 (Kv7/KCNQ). It induces relaxation of preconstricted pulmonary arteries isolated from wild-type and serotonin transporter-overexpressing (SERT+) mice. Flupirtine (30 mg/kg per day) decreases mean right ventricular pressure and right ventricular...

Astragalosides are bioactive saponins isolated from dried roots of plants of the genus Astragalus, which is used in traditional Chinese medicine. Astragaloside A is known to have diverse protective effects for the cardiovascular, immune, digestive, and nervous systems. More specifically, it protects cardiomyocytes...

(-)-Norepinephrine is the endogenous isomer of (±)-norepinephrine (Cay-35580) that acts as a neurotransmitter and hormone and is biosynthesized from dopamine by dopamine beta-hydroxylase. It is an agonist of adrenergic receptors (Ki values are 330, 56, and 740 nM for alpha1, alpha2, and beta1 adrenoceptors,...