- Search results for Cay16442-%25
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7 products were found matching "Cay16442-%25"!
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Item number: Cay16424-25
The bromodomain and extra terminal (BET) proteins interact with acetylated lysine-containing sequences on target proteins via their bromodomains, commonly altering gene transcription. The human BET proteins contain two bromodomains, the first (BD1) being closer to the N-terminus than the second (BD2). RVX-208 is a...
Keywords: | 2-[4-(2-hydroxyethoxy)-3,5-dimethylphenyl]-5,7-dimethoxy-4(3H)-quinazolinone |
Application: | BET bromodomain BD2 antagonist |
CAS | 1044870-39-4 |
MW: | 370.4 D |
From 60.00€
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Item number: Cay16441-25
SMYD2 is a lysine N-methyltransferase that methylates both histones and non-histone proteins, including p53 and retinoblastoma-associated protein. LLY-507 is a cell-active, small molecule inhibitor of SMYD2 (IC50 = 15 nM). It has been shown to inhibit p53 lysine370 monomethylation in KYSE-150 esophageal squamous...
Keywords: | 5-cyano-2'-[4-[2-(3-methyl-1H-indol-1-yl)ethyl]-1-piperazinyl]-N-[3-(1-pyrrolidinyl)propyl]-[1,1'-biphenyl]-3-carboxamide |
Application: | SMYD2 inhibitor |
CAS | 1793053-37-8 |
MW: | 574.8 D |
From 77.00€
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Item number: Cay16449-25
TNP-470 is a synthetic analog of fumagillin (Cay-11332) that inhibits angiogenesis. It irreversibly inactivates methionine aminopeptidase-2 (MetAP2, IC50 = 2 µM), blocking endothelial cell proliferation in vitro and angiogenesis in vivo. It is without effect on MetAP1. TNP-470 has therapeutic potential in cancer and...
Keywords: | AGM-1470, NSC 642492, O-(Chloroacetyl-carbamoyl) Fumagillol,... |
Application: | Synthetic fumagillin analog, irreversible MetAP2 inhibitor, angiogenesis inhibitor |
CAS | 129298-91-5 |
MW: | 401.9 D |
From 122.00€
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Item number: Cay16464-25
alpha-D-Glucose-1,6-bisphosphate is a bis-phosphorylated derivative of alpha-D-glucose that has roles in carbohydrate metabolism. It is the product of the reaction of glucose-1- or 6-phosphate with glucose-1,6-bisphosphate synthase (PGM2LI) in the conversion of 1,3-bisphosphoglycerate to 3-phosphoglycerate. It is...
Keywords: | D-Glucose-1,6-diphosphate, Glc-1,6-P2, alpha-D-glucopyranose, 1,6-bis(dihydrogen phosphate), cyclohexanamine (1:4), hydrate |
Application: | alpha-/beta-phosphoglucomutase / hexoglucomutase identification, differentiation, characterization |
MW: | 736.8 D |
From 60.00€
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Item number: Cay16404-25
CMP-Sialic acid is a form of the sugar N-acetylneuraminic acid (Neu5Ac) O-linked with the nucleotide cytidine-5'-monophosphate (CMP). In vertebrates, it is biosynthesized within the nucleus from CTP and Neu5Ac by CMP-sialic acid synthetases. Sialyltransferases transfer Neu5Ac from CMP-sialic acid to various acceptor...
Keywords: | CMP-Neu5Ac, N-acetyl-2-(hydrogen 5'-cytidylate)-beta-neuraminic acid, monosodium salt |
Application: | Sialyltransferase substrate |
CAS | 1007117-62-5 |
MW: | 636.4 D |
From 77.00€
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Item number: Cay21644-25
ZLN024 is an allosteric activator of AMP-activated protein kinase (AMPK) heterotrimers (EC50s = 0.42 and 0.95 µM for alpha1beta1gamma1 and alpha2beta1gamma1, respectively). Activation of AMPK by ZLN024 requires phosphorylation of AMPK on Thr172, and ZLN024 protects Thr172 from dephosphorylation by protein...
Keywords: | 2-[[2-(2-bromo-4-methylphenoxy)ethyl]thio]-pyrimidine |
Application: | AMPK activator |
CAS | 723249-01-2 |
MW: | 325.2 D |
From 129.00€
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Item number: Cay14426-25
Cordycepin is a nucleoside analog originally isolated from C. militaris that has diverse biological activities. Upon entry into cells, it is converted to cordycepin triphosphate, which inhibits ATP-dependent DNA and RNA synthesis. It incorporates into DNA and RNA at internal and terminal positions in SK-HEP-1 cells....
Keywords: | 3'-Deoxyadenosine, NSC 401022, NSC 63984, 3'-deoxy-adenosine |
Application: | Nucleoside analog, polyadenylation inhibitor |
CAS | 73-03-0 |
MW: | 251.2 D |
From 46.00€
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