7 products were found matching "Cay16442-%25"!

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RVX-208
RVX-208

Item number: Cay16424-25

The bromodomain and extra terminal (BET) proteins interact with acetylated lysine-containing sequences on target proteins via their bromodomains, commonly altering gene transcription. The human BET proteins contain two bromodomains, the first (BD1) being closer to the N-terminus than the second (BD2). RVX-208 is a...
Keywords: 2-[4-(2-hydroxyethoxy)-3,5-dimethylphenyl]-5,7-dimethoxy-4(3H)-quinazolinone
Application: BET bromodomain BD2 antagonist
CAS 1044870-39-4
MW: 370.4 D
From 60.00€ *
Review
LLY-507
LLY-507

Item number: Cay16441-25

SMYD2 is a lysine N-methyltransferase that methylates both histones and non-histone proteins, including p53 and retinoblastoma-associated protein. LLY-507 is a cell-active, small molecule inhibitor of SMYD2 (IC50 = 15 nM). It has been shown to inhibit p53 lysine370 monomethylation in KYSE-150 esophageal squamous...
Keywords: 5-cyano-2'-[4-[2-(3-methyl-1H-indol-1-yl)ethyl]-1-piperazinyl]-N-[3-(1-pyrrolidinyl)propyl]-[1,1'-biphenyl]-3-carboxamide
Application: SMYD2 inhibitor
CAS 1793053-37-8
MW: 574.8 D
From 77.00€ *
Review
TNP-470
TNP-470

Item number: Cay16449-25

TNP-470 is a synthetic analog of fumagillin (Cay-11332) that inhibits angiogenesis. It irreversibly inactivates methionine aminopeptidase-2 (MetAP2, IC50 = 2 µM), blocking endothelial cell proliferation in vitro and angiogenesis in vivo. It is without effect on MetAP1. TNP-470 has therapeutic potential in cancer and...
Keywords: AGM-1470, NSC 642492, O-(Chloroacetyl-carbamoyl) Fumagillol,...
Application: Synthetic fumagillin analog, irreversible MetAP2 inhibitor, angiogenesis inhibitor
CAS 129298-91-5
MW: 401.9 D
From 122.00€ *
Review
alpha-D-Glucose-1,6-bisphosphate (cyclohexyl ammonium salt hydrate)
alpha-D-Glucose-1,6-bisphosphate (cyclohexyl ammonium...

Item number: Cay16464-25

alpha-D-Glucose-1,6-bisphosphate is a bis-phosphorylated derivative of alpha-D-glucose that has roles in carbohydrate metabolism. It is the product of the reaction of glucose-1- or 6-phosphate with glucose-1,6-bisphosphate synthase (PGM2LI) in the conversion of 1,3-bisphosphoglycerate to 3-phosphoglycerate. It is...
Keywords: D-Glucose-1,6-diphosphate, Glc-1,6-P2, alpha-D-glucopyranose, 1,6-bis(dihydrogen phosphate), cyclohexanamine (1:4), hydrate
Application: alpha-/beta-phosphoglucomutase / hexoglucomutase identification, differentiation, characterization
MW: 736.8 D
From 60.00€ *
Review
CMP-Sialic Acid (sodium salt)
CMP-Sialic Acid (sodium salt)

Item number: Cay16404-25

CMP-Sialic acid is a form of the sugar N-acetylneuraminic acid (Neu5Ac) O-linked with the nucleotide cytidine-5'-monophosphate (CMP). In vertebrates, it is biosynthesized within the nucleus from CTP and Neu5Ac by CMP-sialic acid synthetases. Sialyltransferases transfer Neu5Ac from CMP-sialic acid to various acceptor...
Keywords: CMP-Neu5Ac, N-acetyl-2-(hydrogen 5'-cytidylate)-beta-neuraminic acid, monosodium salt
Application: Sialyltransferase substrate
CAS 1007117-62-5
MW: 636.4 D
From 77.00€ *
Review
ZLN024
ZLN024

Item number: Cay21644-25

ZLN024 is an allosteric activator of AMP-activated protein kinase (AMPK) heterotrimers (EC50s = 0.42 and 0.95 µM for alpha1beta1gamma1 and alpha2beta1gamma1, respectively). Activation of AMPK by ZLN024 requires phosphorylation of AMPK on Thr172, and ZLN024 protects Thr172 from dephosphorylation by protein...
Keywords: 2-[[2-(2-bromo-4-methylphenoxy)ethyl]thio]-pyrimidine
Application: AMPK activator
CAS 723249-01-2
MW: 325.2 D
From 129.00€ *
Review
Cordycepin
Cordycepin

Item number: Cay14426-25

Cordycepin is a nucleoside analog originally isolated from C. militaris that has diverse biological activities. Upon entry into cells, it is converted to cordycepin triphosphate, which inhibits ATP-dependent DNA and RNA synthesis. It incorporates into DNA and RNA at internal and terminal positions in SK-HEP-1 cells....
Keywords: 3'-Deoxyadenosine, NSC 401022, NSC 63984, 3'-deoxy-adenosine
Application: Nucleoside analog, polyadenylation inhibitor
CAS 73-03-0
MW: 251.2 D
From 46.00€ *
Review